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Compile Data Set for Download or QSAR

Found 240 hits with Last Name = 'corless' and Initial = 'm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257637
PNG
(1-(4-aminopyridin-2-yl)-4-phenyl-N-(quinolin-2-yl)...)
Show SMILES Nc1ccnc(c1)N1CCC(CC1)(C(=O)Nc1ccc2ccccc2n1)c1ccccc1
Show InChI InChI=1S/C26H25N5O/c27-21-12-15-28-24(18-21)31-16-13-26(14-17-31,20-7-2-1-3-8-20)25(32)30-23-11-10-19-6-4-5-9-22(19)29-23/h1-12,15,18H,13-14,16-17H2,(H2,27,28)(H,29,30,32)
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17n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257723
PNG
(2-(3-phenyl-3H-spiro[isobenzofuran-1,4'-piperidine...)
Show SMILES Nc1ccnc(c1)N1CCC2(CC1)OC(c1ccccc21)c1ccccc1
Show InChI InChI=1S/C23H23N3O/c24-18-10-13-25-21(16-18)26-14-11-23(12-15-26)20-9-5-4-8-19(20)22(27-23)17-6-2-1-3-7-17/h1-10,13,16,22H,11-12,14-15H2,(H2,24,25)
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18n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257639
PNG
((1-(4-aminopyridin-2-yl)-4-phenylpiperidin-4-yl)(3...)
Show SMILES Nc1ccnc(c1)N1CCC(CC1)(C(=O)N1CCc2ccccc2C1)c1ccccc1
Show InChI InChI=1S/C26H28N4O/c27-23-10-14-28-24(18-23)29-16-12-26(13-17-29,22-8-2-1-3-9-22)25(31)30-15-11-20-6-4-5-7-21(20)19-30/h1-10,14,18H,11-13,15-17,19H2,(H2,27,28)
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35n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257684
PNG
(CHEMBL495346 | N-(1-(4-aminopyridin-2-yl)-4-phenyl...)
Show SMILES COc1ccc(C(=O)NC2(CCN(CC2)c2cc(N)ccn2)c2ccccc2)c(OC)c1
Show InChI InChI=1S/C25H28N4O3/c1-31-20-8-9-21(22(17-20)32-2)24(30)28-25(18-6-4-3-5-7-18)11-14-29(15-12-25)23-16-19(26)10-13-27-23/h3-10,13,16-17H,11-12,14-15H2,1-2H3,(H2,26,27)(H,28,30)
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82n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257638
PNG
(CHEMBL493743 | ethyl 4-(1-(4-aminopyridin-2-yl)-4-...)
Show SMILES CCOC(=O)N1CCN(CC1)C(=O)C1(CCN(CC1)c1cc(N)ccn1)c1ccccc1
Show InChI InChI=1S/C24H31N5O3/c1-2-32-23(31)29-16-14-28(15-17-29)22(30)24(19-6-4-3-5-7-19)9-12-27(13-10-24)21-18-20(25)8-11-26-21/h3-8,11,18H,2,9-10,12-17H2,1H3,(H2,25,26)
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169n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257683
PNG
(1-(4-aminopyridin-2-yl)-N-(4-methoxybenzyl)-4-phen...)
Show SMILES COc1ccc(CNC(=O)C2(CCN(CC2)c2cc(N)ccn2)c2ccccc2)cc1
Show InChI InChI=1S/C25H28N4O2/c1-31-22-9-7-19(8-10-22)18-28-24(30)25(20-5-3-2-4-6-20)12-15-29(16-13-25)23-17-21(26)11-14-27-23/h2-11,14,17H,12-13,15-16,18H2,1H3,(H2,26,27)(H,28,30)
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201n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257685
PNG
(CHEMBL492330 | N-(1-(4-aminopyridin-2-yl)-4-phenyl...)
Show SMILES COc1ccc(cc1Cl)C(=O)NC1(CCN(CC1)c1cc(N)ccn1)c1ccccc1
Show InChI InChI=1S/C24H25ClN4O2/c1-31-21-8-7-17(15-20(21)25)23(30)28-24(18-5-3-2-4-6-18)10-13-29(14-11-24)22-16-19(26)9-12-27-22/h2-9,12,15-16H,10-11,13-14H2,1H3,(H2,26,27)(H,28,30)
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343n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257833
PNG
(3-(1-(4-aminopyridin-2-yl)piperidin-4-yl)-1-benzyl...)
Show SMILES Nc1ccnc(c1)N1CCC(CC1)n1c2ncccc2n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H24N6O/c24-18-8-12-25-21(15-18)27-13-9-19(10-14-27)29-22-20(7-4-11-26-22)28(23(29)30)16-17-5-2-1-3-6-17/h1-8,11-12,15,19H,9-10,13-14,16H2,(H2,24,25)
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518n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257686
PNG
(CHEMBL522317 | N-(1-(4-aminopyridin-2-yl)-4-phenyl...)
Show SMILES Nc1ccnc(c1)N1CCC(CC1)(NC(=O)c1ccccn1)c1ccccc1
Show InChI InChI=1S/C22H23N5O/c23-18-9-13-25-20(16-18)27-14-10-22(11-15-27,17-6-2-1-3-7-17)26-21(28)19-8-4-5-12-24-19/h1-9,12-13,16H,10-11,14-15H2,(H2,23,25)(H,26,28)
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548n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257834
PNG
(3-(1-(4-aminopyridin-2-yl)piperidin-4-yl)-1-(cyclo...)
Show SMILES Nc1ccnc(c1)N1CCC(CC1)n1c2ncccc2n(CC2CC2)c1=O
Show InChI InChI=1S/C20H24N6O/c21-15-5-9-22-18(12-15)24-10-6-16(7-11-24)26-19-17(2-1-8-23-19)25(20(26)27)13-14-3-4-14/h1-2,5,8-9,12,14,16H,3-4,6-7,10-11,13H2,(H2,21,22)
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746n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257831
PNG
(3-(1-(4-aminopyridin-2-yl)piperidin-4-yl)-1-(4-met...)
Show SMILES COc1ccc(cc1)-n1c2cccnc2n(C2CCN(CC2)c2cc(N)ccn2)c1=O
Show InChI InChI=1S/C23H24N6O2/c1-31-19-6-4-17(5-7-19)28-20-3-2-11-26-22(20)29(23(28)30)18-9-13-27(14-10-18)21-15-16(24)8-12-25-21/h2-8,11-12,15,18H,9-10,13-14H2,1H3,(H2,24,25)
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865n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257832
PNG
(3-(1-(4-aminopyridin-2-yl)piperidin-4-yl)-1-phenyl...)
Show SMILES Nc1ccnc(c1)N1CCC(CC1)n1c2ncccc2n(-c2ccccc2)c1=O
Show InChI InChI=1S/C22H22N6O/c23-16-8-12-24-20(15-16)26-13-9-18(10-14-26)28-21-19(7-4-11-25-21)27(22(28)29)17-5-2-1-3-6-17/h1-8,11-12,15,18H,9-10,13-14H2,(H2,23,24)
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903n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257781
PNG
(2-(3-(3-methoxyphenyl)-3-methylazetidin-1-yl)pyrid...)
Show SMILES COc1cccc(c1)C1(C)CN(C1)c1cc(N)ccn1
Show InChI InChI=1S/C16H19N3O/c1-16(12-4-3-5-14(8-12)20-2)10-19(11-16)15-9-13(17)6-7-18-15/h3-9H,10-11H2,1-2H3,(H2,17,18)
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1.84E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257780
PNG
((S)-1'-(4-aminopyridin-2-yl)-N,N-dimethyl-2,3-dihy...)
Show SMILES CN(C)C(=O)[C@H]1CC2(CCN(CC2)c2cc(N)ccn2)c2ccccc12 |r|
Show InChI InChI=1S/C21H26N4O/c1-24(2)20(26)17-14-21(18-6-4-3-5-16(17)18)8-11-25(12-9-21)19-13-15(22)7-10-23-19/h3-7,10,13,17H,8-9,11-12,14H2,1-2H3,(H2,22,23)/t17-/m0/s1
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4.71E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257782
PNG
(CHEMBL493515 | N-(1-(4-aminopyridin-2-yl)piperidin...)
Show SMILES COc1ccc(cc1)C(=O)N(C1CCN(CC1)c1cc(N)ccn1)c1cc(C)ccn1
Show InChI InChI=1S/C24H27N5O2/c1-17-7-11-27-23(15-17)29(24(30)18-3-5-21(31-2)6-4-18)20-9-13-28(14-10-20)22-16-19(25)8-12-26-22/h3-8,11-12,15-16,20H,9-10,13-14H2,1-2H3,(H2,25,26)
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5.03E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50170969
PNG
((S)-1-(1-Cyclopropyl-cyclopentyl)-5-(3,4-dichloro-...)
Show SMILES Clc1ccc(cc1Cl)[C@@]1(CCN2CC(C2)N2CCOCC2)CCC(=O)N(C1)C1(CCCC1)C1CC1
Show InChI InChI=1S/C28H39Cl2N3O2/c29-24-6-5-22(17-25(24)30)27(11-12-31-18-23(19-31)32-13-15-35-16-14-32)10-7-26(34)33(20-27)28(21-3-4-21)8-1-2-9-28/h5-6,17,21,23H,1-4,7-16,18-20H2/t27-/m1/s1
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9.50E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Ki for human Neurokinin 2 receptor


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257784
PNG
(CHEMBL493517 | N-(1-(4-aminopyridin-2-yl)piperidin...)
Show SMILES COc1cccc(c1)C(=O)N(C1CCN(CC1)c1cc(N)ccn1)c1ccccn1
Show InChI InChI=1S/C23H25N5O2/c1-30-20-6-4-5-17(15-20)23(29)28(21-7-2-3-11-25-21)19-9-13-27(14-10-19)22-16-18(24)8-12-26-22/h2-8,11-12,15-16,19H,9-10,13-14H2,1H3,(H2,24,26)
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9.69E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257722
PNG
((S)-1'-(4-aminopyridin-2-yl)-N,N-diethyl-3H-spiro[...)
Show SMILES CCN(CC)C(=O)[C@H]1OC2(CCN(CC2)c2cc(N)ccn2)c2ccccc12 |r|
Show InChI InChI=1S/C22H28N4O2/c1-3-25(4-2)21(27)20-17-7-5-6-8-18(17)22(28-20)10-13-26(14-11-22)19-15-16(23)9-12-24-19/h5-9,12,15,20H,3-4,10-11,13-14H2,1-2H3,(H2,23,24)/t20-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257783
PNG
(CHEMBL493516 | N-(1-(4-aminopyridin-2-yl)piperidin...)
Show SMILES Nc1ccnc(c1)N1CCC(CC1)N(C(=O)C1CCCCC1)c1ccccn1
Show InChI InChI=1S/C22H29N5O/c23-18-9-13-25-21(16-18)26-14-10-19(11-15-26)27(20-8-4-5-12-24-20)22(28)17-6-2-1-3-7-17/h4-5,8-9,12-13,16-17,19H,1-3,6-7,10-11,14-15H2,(H2,23,25)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257830
PNG
(CHEMBL493781 | N-(1-(4-aminopyridin-2-yl)piperidin...)
Show SMILES Nc1ccnc(c1)N1CCC(CC1)N(C(=O)C1CC1)c1ccccn1
Show InChI InChI=1S/C19H23N5O/c20-15-6-10-22-18(13-15)23-11-7-16(8-12-23)24(19(25)14-4-5-14)17-3-1-2-9-21-17/h1-3,6,9-10,13-14,16H,4-5,7-8,11-12H2,(H2,20,22)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50170967
PNG
((S)-1-(1-Cyclopropyl-cyclopentyl)-5-(3,4-dichloro-...)
Show SMILES FC1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(C2)C2(CCCC2)C2CC2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C29H40Cl2FN3O/c30-25-6-5-22(17-26(25)31)28(13-16-33-18-24(19-33)34-14-8-23(32)9-15-34)12-7-27(36)35(20-28)29(21-3-4-21)10-1-2-11-29/h5-6,17,21,23-24H,1-4,7-16,18-20H2/t28-/m1/s1
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Ki for human Neurokinin 2 receptor


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257719
PNG
((S)-N-(1-(4-aminopyridin-2-yl)-4-phenylpiperidin-4...)
Show SMILES Nc1ccnc(c1)N1CCC(CC1)(NC(=O)[C@@H]1CCCO1)c1ccccc1 |r|
Show InChI InChI=1S/C21H26N4O2/c22-17-8-11-23-19(15-17)25-12-9-21(10-13-25,16-5-2-1-3-6-16)24-20(26)18-7-4-14-27-18/h1-3,5-6,8,11,15,18H,4,7,9-10,12-14H2,(H2,22,23)(H,24,26)/t18-/m0/s1
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 19: 1702-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.106
BindingDB Entry DOI: 10.7270/Q21G0M40
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359779
PNG
(CHEMBL1928271)
Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCC2CC2)c(c1)-c1nc2c(CC)n(CCN3CCOCC3)nc2c(=O)[nH]1
Show InChI InChI=1S/C28H40N8O5S/c1-3-23-24-25(32-36(23)12-9-34-13-15-40-16-14-34)27(37)31-26(30-24)22-17-21(18-29-28(22)41-19-20-5-6-20)42(38,39)35-10-7-33(4-2)8-11-35/h17-18,20H,3-16,19H2,1-2H3,(H,30,31,37)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359773
PNG
(CHEMBL1928265)
Show SMILES CCCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CCN(CC1)S(C)(=O)=O)S(=O)(=O)N1CCN(CC)CC1
Show InChI InChI=1S/C28H42N8O6S2/c1-5-8-17-42-28-22(18-21(19-29-28)44(40,41)35-15-13-33(7-3)14-16-35)26-30-24-23(6-2)36(32-25(24)27(37)31-26)20-9-11-34(12-10-20)43(4,38)39/h18-20H,5-17H2,1-4H3,(H,30,31,37)
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n/an/a 0.310n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50170968
PNG
((S)-5-(3,4-Dichloro-phenyl)-1-(4,4-difluoro-cycloh...)
Show SMILES FC1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(CC3CCC(F)(F)CC3)C2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C28H38Cl2F3N3O/c29-24-2-1-21(15-25(24)30)27(11-14-34-17-23(18-34)35-12-6-22(31)7-13-35)8-5-26(37)36(19-27)16-20-3-9-28(32,33)10-4-20/h1-2,15,20,22-23H,3-14,16-19H2/t27-/m1/s1
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neurokinin 2 receptor


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50276291
PNG
(CHEMBL472464 | N-benzyl-N-(1'-(2,6-dimethylbenzoyl...)
Show SMILES Cc1cccc(C)c1C(=O)N1CCC(C)(CC1)N1CCC(CC1)N(Cc1ccccc1)C(=O)C1CC1
Show InChI InChI=1S/C31H41N3O2/c1-23-8-7-9-24(2)28(23)30(36)32-20-16-31(3,17-21-32)33-18-14-27(15-19-33)34(29(35)26-12-13-26)22-25-10-5-4-6-11-25/h4-11,26-27H,12-22H2,1-3H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...


Bioorg Med Chem Lett 19: 1084-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.012
BindingDB Entry DOI: 10.7270/Q2W095SG
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50197517
PNG
((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Show SMILES COCC[C@H](CC1(CCCC1)C(=O)NCCCc1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C21H30ClNO4/c1-27-14-10-17(19(24)25)15-21(11-2-3-12-21)20(26)23-13-4-5-16-6-8-18(22)9-7-16/h6-9,17H,2-5,10-15H2,1H3,(H,23,26)(H,24,25)/t17-/m1/s1
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n/an/a 0.600n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat NEP


Bioorg Med Chem 15: 142-59 (2006)


Article DOI: 10.1016/j.bmc.2006.10.002
BindingDB Entry DOI: 10.7270/Q2ZS2W4J
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359795
PNG
(CHEMBL1928258)
Show SMILES CCCOc1ncc(cc1-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1
Show InChI InChI=1S/C24H35N7O5S/c1-5-13-36-24-18(15-17(16-25-24)37(33,34)30-10-8-29(7-3)9-11-30)22-26-20-19(6-2)31(12-14-35-4)28-21(20)23(32)27-22/h15-16H,5-14H2,1-4H3,(H,26,27,32)
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n/an/a 0.690n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359767
PNG
(CHEMBL1928259)
Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCC(C)C)c(c1)-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1
Show InChI InChI=1S/C25H37N7O5S/c1-6-20-21-22(29-32(20)12-13-36-5)24(33)28-23(27-21)19-14-18(15-26-25(19)37-16-17(3)4)38(34,35)31-10-8-30(7-2)9-11-31/h14-15,17H,6-13,16H2,1-5H3,(H,27,28,33)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359774
PNG
(CHEMBL1928266)
Show SMILES CCCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CCN(C)CC1)S(=O)(=O)N1CCN(CC)CC1
Show InChI InChI=1S/C28H42N8O4S/c1-5-8-17-40-28-22(18-21(19-29-28)41(38,39)35-15-13-34(7-3)14-16-35)26-30-24-23(6-2)36(32-25(24)27(37)31-26)20-9-11-33(4)12-10-20/h18-20H,5-17H2,1-4H3,(H,30,31,37)
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n/an/a 0.740n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359768
PNG
(CHEMBL1928260)
Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCc2ccccn2)c(c1)-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1
Show InChI InChI=1S/C27H34N8O5S/c1-4-22-23-24(32-35(22)14-15-39-3)26(36)31-25(30-23)21-16-20(41(37,38)34-12-10-33(5-2)11-13-34)17-29-27(21)40-18-19-8-6-7-9-28-19/h6-9,16-17H,4-5,10-15,18H2,1-3H3,(H,30,31,36)
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n/an/a 0.75n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359777
PNG
(CHEMBL1928269)
Show SMILES CCCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CN(C)C1)S(=O)(=O)N1CCN(CC)CC1
Show InChI InChI=1S/C26H38N8O4S/c1-5-8-13-38-26-20(14-19(15-27-26)39(36,37)33-11-9-32(7-3)10-12-33)24-28-22-21(6-2)34(18-16-31(4)17-18)30-23(22)25(35)29-24/h14-15,18H,5-13,16-17H2,1-4H3,(H,28,29,35)
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n/an/a 0.780n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50409627
PNG
(CHEMBL185572)
Show SMILES Clc1ccc(cc1Cl)[C@@]1(CCN2CC(C2)N2CCOCC2)CCC(=O)N(CC2CCCCC2)C1
Show InChI InChI=1S/C27H39Cl2N3O2/c28-24-7-6-22(16-25(24)29)27(10-11-30-18-23(19-30)31-12-14-34-15-13-31)9-8-26(33)32(20-27)17-21-4-2-1-3-5-21/h6-7,16,21,23H,1-5,8-15,17-20H2/t27-/m1/s1
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n/an/a 0.790n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neurokinin 2 receptor


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50197517
PNG
((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Show SMILES COCC[C@H](CC1(CCCC1)C(=O)NCCCc1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C21H30ClNO4/c1-27-14-10-17(19(24)25)15-21(11-2-3-12-21)20(26)23-13-4-5-16-6-8-18(22)9-7-16/h6-9,17H,2-5,10-15H2,1H3,(H,23,26)(H,24,25)/t17-/m1/s1
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n/an/a 0.800n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rabbit NEP


Bioorg Med Chem 15: 142-59 (2006)


Article DOI: 10.1016/j.bmc.2006.10.002
BindingDB Entry DOI: 10.7270/Q2ZS2W4J
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359778
PNG
(CHEMBL1928270)
Show SMILES CCOc1ncc(cc1-c1nc2c(CC)n(CCN3CCOCC3)nc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1
Show InChI InChI=1S/C26H38N8O5S/c1-4-21-22-23(30-34(21)12-9-32-13-15-38-16-14-32)25(35)29-24(28-22)20-17-19(18-27-26(20)39-6-3)40(36,37)33-10-7-31(5-2)8-11-33/h17-18H,4-16H2,1-3H3,(H,28,29,35)
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n/an/a 0.860n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359789
PNG
(CHEMBL1928252)
Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(CC(C)C)nc2c(=O)[nH]1
Show InChI InChI=1S/C25H37N7O5S/c1-6-20-21-22(29-32(20)16-17(3)4)24(33)28-23(27-21)19-14-18(15-26-25(19)37-13-12-36-5)38(34,35)31-10-8-30(7-2)9-11-31/h14-15,17H,6-13,16H2,1-5H3,(H,27,28,33)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359771
PNG
(CHEMBL1928263)
Show SMILES CCCCOc1ncc(cc1-c1nc2c(CC)n(CCN(C)C)nc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1
Show InChI InChI=1S/C26H40N8O4S/c1-6-9-16-38-26-20(17-19(18-27-26)39(36,37)33-13-11-32(8-3)12-14-33)24-28-22-21(7-2)34(15-10-31(4)5)30-23(22)25(35)29-24/h17-18H,6-16H2,1-5H3,(H,28,29,35)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359790
PNG
(CHEMBL1928253)
Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(CC3CC3)nc2c(=O)[nH]1
Show InChI InChI=1S/C25H35N7O5S/c1-4-20-21-22(29-32(20)16-17-6-7-17)24(33)28-23(27-21)19-14-18(15-26-25(19)37-13-12-36-3)38(34,35)31-10-8-30(5-2)9-11-31/h14-15,17H,4-13,16H2,1-3H3,(H,27,28,33)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50410049
PNG
(CHEMBL434142)
Show SMILES NC1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(CC3CCC(F)(F)CC3)C2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C28H40Cl2F2N4O/c29-24-2-1-21(15-25(24)30)27(11-14-34-17-23(18-34)35-12-6-22(33)7-13-35)8-5-26(37)36(19-27)16-20-3-9-28(31,32)10-4-20/h1-2,15,20,22-23H,3-14,16-19,33H2/t27-/m1/s1
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neurokinin 2 receptor


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50276260
PNG
((R)-N-benzyl-N-(1-(1-(2,6-dimethylbenzoyl)piperidi...)
Show SMILES Cc1cccc(C)c1C(=O)N1CCC(CC1)N1CC[C@H](C1)N(Cc1ccccc1)C(=O)C1CC1 |r|
Show InChI InChI=1S/C29H37N3O2/c1-21-7-6-8-22(2)27(21)29(34)30-16-13-25(14-17-30)31-18-15-26(20-31)32(28(33)24-11-12-24)19-23-9-4-3-5-10-23/h3-10,24-26H,11-20H2,1-2H3/t26-/m1/s1
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...


Bioorg Med Chem Lett 19: 1084-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.012
BindingDB Entry DOI: 10.7270/Q2W095SG
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50276259
PNG
(CHEMBL481068 | exo-N-benzyl-N-((R)-1-(8-(2,6-dimet...)
Show SMILES Cc1cccc(C)c1C(=O)N1[C@H]2CC[C@@H]1C[C@H](C2)N1CC[C@H](C1)N(Cc1ccccc1)C(=O)C1CC1 |r,THB:8:10:15.16.17:12.13|
Show InChI InChI=1S/C31H39N3O2/c1-21-7-6-8-22(2)29(21)31(36)34-25-13-14-26(34)18-28(17-25)32-16-15-27(20-32)33(30(35)24-11-12-24)19-23-9-4-3-5-10-23/h3-10,24-28H,11-20H2,1-2H3/t25-,26+,27-,28-/m1/s1
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...


Bioorg Med Chem Lett 19: 1084-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.012
BindingDB Entry DOI: 10.7270/Q2W095SG
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50246483
PNG
(3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2-pro...)
Show SMILES CCCOc1ncc(cc1-c1nc2c(CC)n(Cc3ccccn3)nc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1
Show InChI InChI=1S/C27H34N8O4S/c1-4-15-39-27-21(16-20(17-29-27)40(37,38)34-13-11-33(6-3)12-14-34)25-30-23-22(5-2)35(32-24(23)26(36)31-25)18-19-9-7-8-10-28-19/h7-10,16-17H,4-6,11-15,18H2,1-3H3,(H,30,31,36)
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n/an/a 1.10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359770
PNG
(CHEMBL1928262)
Show SMILES CCOc1ncc(cc1-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1
Show InChI InChI=1S/C23H33N7O5S/c1-5-18-19-20(27-30(18)12-13-34-4)22(31)26-21(25-19)17-14-16(15-24-23(17)35-7-3)36(32,33)29-10-8-28(6-2)9-11-29/h14-15H,5-13H2,1-4H3,(H,25,26,31)
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n/an/a 1.20n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50410051
PNG
(CHEMBL185182)
Show SMILES CS(=O)(=O)N1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(CC3CCC(F)(F)CC3)C2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C28H40Cl2F2N4O3S/c1-40(38,39)36-14-12-34(13-15-36)23-18-33(19-23)11-10-27(22-2-3-24(29)25(30)16-22)7-6-26(37)35(20-27)17-21-4-8-28(31,32)9-5-21/h2-3,16,21,23H,4-15,17-20H2,1H3/t27-/m1/s1
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neurokinin 2 receptor


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359780
PNG
(CHEMBL1928272)
Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(CCN3CCOCC3)nc2c(=O)[nH]1
Show InChI InChI=1S/C27H40N8O6S/c1-4-22-23-24(31-35(22)11-8-33-12-14-40-15-13-33)26(36)30-25(29-23)21-18-20(19-28-27(21)41-17-16-39-3)42(37,38)34-9-6-32(5-2)7-10-34/h18-19H,4-17H2,1-3H3,(H,29,30,36)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))
BDBM50410048
PNG
(CHEMBL434548)
Show SMILES OC1CCN(CC1)C1CN(CC[C@@]2(CCC(=O)N(CC3CCC(F)(F)CC3)C2)c2ccc(Cl)c(Cl)c2)C1
Show InChI InChI=1S/C28H39Cl2F2N3O2/c29-24-2-1-21(15-25(24)30)27(11-14-33-17-22(18-33)34-12-6-23(36)7-13-34)8-5-26(37)35(19-27)16-20-3-9-28(31,32)10-4-20/h1-2,15,20,22-23,36H,3-14,16-19H2/t27-/m1/s1
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neurokinin 2 receptor


Bioorg Med Chem Lett 15: 3957-61 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.134
BindingDB Entry DOI: 10.7270/Q20G3JQM
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359787
PNG
(CHEMBL1928250)
Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(nc2c(=O)[nH]1)C(C)C
Show InChI InChI=1S/C24H35N7O5S/c1-6-19-20-21(28-31(19)16(3)4)23(32)27-22(26-20)18-14-17(15-25-24(18)36-13-12-35-5)37(33,34)30-10-8-29(7-2)9-11-30/h14-16H,6-13H2,1-5H3,(H,26,27,32)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359769
PNG
(CHEMBL1928261)
Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1
Show InChI InChI=1S/C24H35N7O6S/c1-5-19-20-21(28-31(19)11-12-35-3)23(32)27-22(26-20)18-15-17(16-25-24(18)37-14-13-36-4)38(33,34)30-9-7-29(6-2)8-10-30/h15-16H,5-14H2,1-4H3,(H,26,27,32)
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n/an/a 1.5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359791
PNG
(CHEMBL1928254)
Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C26H37N7O6S/c1-4-21-22-23(30-33(21)18-6-12-38-13-7-18)25(34)29-24(28-22)20-16-19(17-27-26(20)39-15-14-37-3)40(35,36)32-10-8-31(5-2)9-11-32/h16-18H,4-15H2,1-3H3,(H,28,29,34)
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n/an/a 1.70n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50359788
PNG
(CHEMBL1928251)
Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CCC1
Show InChI InChI=1S/C25H35N7O5S/c1-4-20-21-22(29-32(20)17-7-6-8-17)24(33)28-23(27-21)19-15-18(16-26-25(19)37-14-13-36-3)38(34,35)31-11-9-30(5-2)10-12-31/h15-17H,4-14H2,1-3H3,(H,27,28,33)
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n/an/a 1.80n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method


Bioorg Med Chem 20: 498-509 (2011)


Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T
More data for this
Ligand-Target Pair
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