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Compile Data Set for Download or QSAR

Found 304 hits with Last Name = 'dai' and Initial = 'g'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ornithine decarboxylase


(Rattus norvegicus)
BDBM50015684
PNG
((racemic+meso) 2-Methyl-pentane-1,4-diamine | CHEM...)
Show SMILES CC(N)CC(C)CN
Show InChI InChI=1S/C6H16N2/c1-5(4-7)3-6(2)8/h5-6H,3-4,7-8H2,1-2H3
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2.90E+6n/an/an/an/an/an/an/an/a



Universidad de Buenos Aires

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Ornithine Decarboxylase (ODC) isolated from the livers of thioactamide treated rats.


J Med Chem 33: 1969-74 (1990)


BindingDB Entry DOI: 10.7270/Q2MG7NH8
More data for this
Ligand-Target Pair
Ornithine decarboxylase


(Rattus norvegicus)
BDBM50015683
PNG
(CHEMBL59625 | N*1*,N*1*-Dimethyl-butane-1,4-diamin...)
Show SMILES CN(C)CCCCN
Show InChI InChI=1S/C6H16N2/c1-8(2)6-4-3-5-7/h3-7H2,1-2H3
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3.00E+6n/an/an/an/an/an/an/an/a



Universidad de Buenos Aires

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Ornithine Decarboxylase (ODC) isolated from the livers of thioactamide treated rats.


J Med Chem 33: 1969-74 (1990)


BindingDB Entry DOI: 10.7270/Q2MG7NH8
More data for this
Ligand-Target Pair
Ornithine decarboxylase


(Rattus norvegicus)
BDBM50009385
PNG
(1,4-butylenediamine | 1,4-tetramethylenediamine | ...)
Show InChI InChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2
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3.30E+6n/an/an/an/an/an/an/an/a



Universidad de Buenos Aires

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Ornithine Decarboxylase (ODC) isolated from the livers of thioactamide treated rats.


J Med Chem 33: 1969-74 (1990)


BindingDB Entry DOI: 10.7270/Q2MG7NH8
More data for this
Ligand-Target Pair
Ornithine decarboxylase


(Rattus norvegicus)
BDBM50015686
PNG
((racemic+meso) 3-Methyl-pentane-1,4-diamine | CHEM...)
Show SMILES CC(N)C(C)CCN
Show InChI InChI=1S/C6H16N2/c1-5(3-4-7)6(2)8/h5-6H,3-4,7-8H2,1-2H3
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3.80E+6n/an/an/an/an/an/an/an/a



Universidad de Buenos Aires

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Ornithine Decarboxylase (ODC) isolated from the livers of thioactamide treated rats.


J Med Chem 33: 1969-74 (1990)


BindingDB Entry DOI: 10.7270/Q2MG7NH8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350391
PNG
((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1 |r|
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n/an/a 0.300n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350389
PNG
(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Show SMILES CC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350454
PNG
((S)-4-amino-6-(0-(3-fluoro-6-phenylimidazo[1,2-b]p...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(F)n2nc1-c1ccccc1 |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350447
PNG
((S)-4-amino-6-((1-(3-chloro-6-(2-hydroxyphenyl)imi...)
Show SMILES COc1ccccc1-c1nn2c(Cl)cnc2cc1[C@H](C)Nc1ncnc(N)c1C#N |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350438
PNG
(US10208066, Compound 60)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccsc1 |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350430
PNG
(US10208066, Compound 49)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccc(O)cc1 |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350430
PNG
(US10208066, Compound 49)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccc(O)cc1 |r|
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US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350398
PNG
(US10208066, Compound 15)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(F)c1 |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350392
PNG
((S)-4-amino-6-((1-(6-phenylimidazo[1,2-b]pyridazin...)
Show SMILES CC[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1 |r|
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HUTCHISON MEDIPHARMA LIMITED

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US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350389
PNG
(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Show SMILES CC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350407
PNG
(US10208066, Compound 24)
Show SMILES CCC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(F)c1
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HUTCHISON MEDIPHARMA LIMITED

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US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350457
PNG
((S)-N4-(1-(3-chloro-6-phenylimidazo[1,2-b]pyridazi...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2ncc(Cl)n2nc1-c1ccccc1 |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350455
PNG
((chiral)-amino-6-((1-(3-chloro-6-(3-(2-hydroxyprop...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(c1)C(C)(C)O |r|
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HUTCHISON MEDIPHARMA LIMITED

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US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350453
PNG
(US10208066, Compound 77)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccnc1 |r|
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HUTCHISON MEDIPHARMA LIMITED

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US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350446
PNG
(US10208066, Compound 68)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1S(C)(=O)=O |r|
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HUTCHISON MEDIPHARMA LIMITED

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US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350443
PNG
(US10208066, Compound 65)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(c1)C#N |r|
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US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350440
PNG
(US10208066, Compound 62)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(C)c1 |r|
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HUTCHISON MEDIPHARMA LIMITED

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US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350434
PNG
(US10208066, Compound 54)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(O)c1 |r|
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HUTCHISON MEDIPHARMA LIMITED

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US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350421
PNG
(US10208066, Compound 40)
Show SMILES C[C@H](Nc1ncnc(N)c1Cl)c1cc2ncc(Cl)n2nc1-c1ccccc1 |r|
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US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350405
PNG
(US10208066, Compound 22)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(C)n2nc1-c1ccccc1 |r|
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US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350402
PNG
(US10208066, Compound 19)
Show SMILES CCC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1F
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US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350396
PNG
(US10208066, Compound 12)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1F |r|
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US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350394
PNG
(US10208066, Compound 9)
Show SMILES C[C@H](Nc1ncnc2[nH]cc(C#N)c12)c1cc2ncc(Cl)n2nc1-c1ccccc1 |r|
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US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350412
PNG
((S)-4-amino-6-((1-(3-chloro-6-(3,5-difluorophenyl)...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cc(F)cc(F)c1 |r|
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US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350397
PNG
(US10208066, Compound 13)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1ccccc1F |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50023344
PNG
(CHEMBL3334569)
Show SMILES C[C@@H](c1ccn2nccc2c1)n1nnc2ncc(nc12)-c1cnn(CCO)c1 |r|
Show InChI InChI=1/C18H17N9O/c1-12(13-3-5-26-15(8-13)2-4-20-26)27-18-17(23-24-27)19-10-16(22-18)14-9-21-25(11-14)6-7-28/h2-5,8-12,28H,6-7H2,1H3/t12-/s2
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Hutchison MediPharma Limited

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human NCI-H441 cells for 1 hr by ELISA


J Med Chem 57: 7577-89 (2014)


Article DOI: 10.1021/jm500510f
BindingDB Entry DOI: 10.7270/Q2JD4ZCR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50023342
PNG
(CHEMBL3334567)
Show SMILES C[C@@H](c1ccc2nccn2c1)n1nnc2ncc(nc12)-c1cnn(C)c1 |r|
Show InChI InChI=1/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/s2
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Hutchison MediPharma Limited

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human NCI-H441 cells for 1 hr by ELISA


J Med Chem 57: 7577-89 (2014)


Article DOI: 10.1021/jm500510f
BindingDB Entry DOI: 10.7270/Q2JD4ZCR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350399
PNG
(US10208066, Compound 16)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1cccc(F)c1 |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350426
PNG
(US10208066, Compound 45)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1C(F)(F)F |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350422
PNG
(US10208066, Compound 41)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(Cl)c1 |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350417
PNG
(US10208066, Compound 36)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(F)c1F |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350395
PNG
(US10208066, Compound 11)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1ccccc1 |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350411
PNG
(US10208066, Compound 29)
Show SMILES CCC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccn1
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350416
PNG
(US10208066, Compound 35)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cc(F)ccc1F |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350401
PNG
(US10208066, Compound 18)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1ccccc1
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350413
PNG
((S)-4-amino-6-((1-(3-chloro-6-(o-tolyl)imidazo[1,2...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1C
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350408
PNG
(US10208066, Compound 25 | US10208066, Compound 26)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1ccccc1F
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350450
PNG
(US10208066, Compound 72)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cnn(C)c1 |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350427
PNG
(US10208066, Compound 46)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(c1)S(C)(=O)=O |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50023335
PNG
(CHEMBL3334540)
Show SMILES FC(F)(F)Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4nccn4c3)c2n1
Show InChI InChI=1S/C17H12F3N9/c18-17(19,20)10-28-9-12(5-23-28)13-6-22-15-16(24-13)29(26-25-15)8-11-1-2-14-21-3-4-27(14)7-11/h1-7,9H,8,10H2
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Hutchison MediPharma Limited

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using Poly E4Y substrate and ATP incubated for 45 mins by fluorescence polarization assay


J Med Chem 57: 7577-89 (2014)


Article DOI: 10.1021/jm500510f
BindingDB Entry DOI: 10.7270/Q2JD4ZCR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50023283
PNG
(CHEMBL3334556)
Show SMILES OCCn1cc(cn1)-c1cnc2nnn(Cc3c[nH]c4ncccc34)c2n1
Show InChI InChI=1S/C17H15N9O/c27-5-4-25-9-12(7-21-25)14-8-20-16-17(22-14)26(24-23-16)10-11-6-19-15-13(11)2-1-3-18-15/h1-3,6-9,27H,4-5,10H2,(H,18,19)
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Hutchison MediPharma Limited

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using Poly E4Y substrate and ATP incubated for 45 mins by fluorescence polarization assay


J Med Chem 57: 7577-89 (2014)


Article DOI: 10.1021/jm500510f
BindingDB Entry DOI: 10.7270/Q2JD4ZCR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50023342
PNG
(CHEMBL3334567)
Show SMILES C[C@@H](c1ccc2nccn2c1)n1nnc2ncc(nc12)-c1cnn(C)c1 |r|
Show InChI InChI=1/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/s2
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Hutchison MediPharma Limited

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using Poly E4Y substrate and ATP incubated for 45 mins by fluorescence polarization assay


J Med Chem 57: 7577-89 (2014)


Article DOI: 10.1021/jm500510f
BindingDB Entry DOI: 10.7270/Q2JD4ZCR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396943
PNG
(CHEMBL2170816)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H14N8/c1-25-11-14(8-21-25)16-9-20-17-18(22-16)26(24-23-17)10-12-4-5-15-13(7-12)3-2-6-19-15/h2-9,11H,10H2,1H3
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Hutchison MediPharma Limited

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using Poly E4Y substrate and ATP incubated for 45 mins by fluorescence polarization assay


J Med Chem 57: 7577-89 (2014)


Article DOI: 10.1021/jm500510f
BindingDB Entry DOI: 10.7270/Q2JD4ZCR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50023333
PNG
(CHEMBL3334551)
Show SMILES OCCn1cc(cn1)-c1cnc2nnn(Cc3ccn4nccc4c3)c2n1
Show InChI InChI=1S/C17H15N9O/c27-6-5-24-11-13(8-20-24)15-9-18-16-17(21-15)26(23-22-16)10-12-2-4-25-14(7-12)1-3-19-25/h1-4,7-9,11,27H,5-6,10H2
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Hutchison MediPharma Limited

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using Poly E4Y substrate and ATP incubated for 45 mins by fluorescence polarization assay


J Med Chem 57: 7577-89 (2014)


Article DOI: 10.1021/jm500510f
BindingDB Entry DOI: 10.7270/Q2JD4ZCR
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350437
PNG
(US10208066, Compound 59)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2nc(C)c(Cl)n2nc1-c1ccccc1 |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350445
PNG
(US10208066, Compound 67)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cc(C)cc(F)c1 |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent




US Patent US10208066 (2019)


BindingDB Entry DOI: 10.7270/Q2319Z0W
More data for this
Ligand-Target Pair
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