new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 75 hits with Last Name = 'donze' and Initial = 'i'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 4


(RAT-Rattus norvegicus)
BDBM50072197
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-6...)
Show SMILES CCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C27H32N2O5/c1-3-26-28-23-14-25(32-9-8-30)24(31-2)13-22(23)27(29-26)19-10-20(33-15-17-4-5-17)12-21(11-19)34-16-18-6-7-18/h10-14,17-18,30H,3-9,15-16H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 15n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL




Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50072197
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-6...)
Show SMILES CCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C27H32N2O5/c1-3-26-28-23-14-25(32-9-8-30)24(31-2)13-22(23)27(29-26)19-10-20(33-15-17-4-5-17)12-21(11-19)34-16-18-6-7-18/h10-14,17-18,30H,3-9,15-16H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 16n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL




Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50072197
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-6...)
Show SMILES CCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C27H32N2O5/c1-3-26-28-23-14-25(32-9-8-30)24(31-2)13-22(23)27(29-26)19-10-20(33-15-17-4-5-17)12-21(11-19)34-16-18-6-7-18/h10-14,17-18,30H,3-9,15-16H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 22n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4D.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT)
BDBM50072197
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-6...)
Show SMILES CCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C27H32N2O5/c1-3-26-28-23-14-25(32-9-8-30)24(31-2)13-22(23)27(29-26)19-10-20(33-15-17-4-5-17)12-21(11-19)34-16-18-6-7-18/h10-14,17-18,30H,3-9,15-16H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 25n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4B.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50072197
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-6...)
Show SMILES CCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C27H32N2O5/c1-3-26-28-23-14-25(32-9-8-30)24(31-2)13-22(23)27(29-26)19-10-20(33-15-17-4-5-17)12-21(11-19)34-16-18-6-7-18/h10-14,17-18,30H,3-9,15-16H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 30n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4A.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT-Rattus norvegicus)
BDBM50072195
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethoxy-...)
Show SMILES CCOc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C27H32N2O6/c1-3-32-27-28-23-14-25(33-9-8-30)24(31-2)13-22(23)26(29-27)19-10-20(34-15-17-4-5-17)12-21(11-19)35-16-18-6-7-18/h10-14,17-18,30H,3-9,15-16H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 43n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL




Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT-Rattus norvegicus)
BDBM50072194
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-butyl-6...)
Show SMILES CCCCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C29H36N2O5/c1-3-4-5-28-30-25-16-27(34-11-10-32)26(33-2)15-24(25)29(31-28)21-12-22(35-17-19-6-7-19)14-23(13-21)36-18-20-8-9-20/h12-16,19-20,32H,3-11,17-18H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 50n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL




Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50072195
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethoxy-...)
Show SMILES CCOc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C27H32N2O6/c1-3-32-27-28-23-14-25(33-9-8-30)24(31-2)13-22(23)26(29-27)19-10-20(34-15-17-4-5-17)12-21(11-19)35-16-18-6-7-18/h10-14,17-18,30H,3-9,15-16H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 60n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4D.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT)
BDBM50072195
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethoxy-...)
Show SMILES CCOc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C27H32N2O6/c1-3-32-27-28-23-14-25(33-9-8-30)24(31-2)13-22(23)26(29-27)19-10-20(34-15-17-4-5-17)12-21(11-19)35-16-18-6-7-18/h10-14,17-18,30H,3-9,15-16H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 70n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4B.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50072211
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(OCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C27H32N2O7/c1-32-24-13-22-23(14-25(24)33-8-6-30)28-27(34-9-7-31)29-26(22)19-10-20(35-15-17-2-3-17)12-21(11-19)36-16-18-4-5-18/h10-14,17-18,30-31H,2-9,15-16H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 70n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4A.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT)
BDBM50072211
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(OCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C27H32N2O7/c1-32-24-13-22-23(14-25(24)33-8-6-30)28-27(34-9-7-31)29-26(22)19-10-20(35-15-17-2-3-17)12-21(11-19)36-16-18-4-5-18/h10-14,17-18,30-31H,2-9,15-16H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 80n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4B.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50072195
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethoxy-...)
Show SMILES CCOc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C27H32N2O6/c1-3-32-27-28-23-14-25(33-9-8-30)24(31-2)13-22(23)26(29-27)19-10-20(34-15-17-4-5-17)12-21(11-19)35-16-18-6-7-18/h10-14,17-18,30H,3-9,15-16H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 85n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4A.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50072211
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(OCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C27H32N2O7/c1-32-24-13-22-23(14-25(24)33-8-6-30)28-27(34-9-7-31)29-26(22)19-10-20(35-15-17-2-3-17)12-21(11-19)36-16-18-4-5-18/h10-14,17-18,30-31H,2-9,15-16H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 90n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4D.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT)
BDBM50072199
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2,6-dimet...)
Show SMILES COc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C26H30N2O6/c1-30-23-12-21-22(13-24(23)32-8-7-29)27-26(31-2)28-25(21)18-9-19(33-14-16-3-4-16)11-20(10-18)34-15-17-5-6-17/h9-13,16-17,29H,3-8,14-15H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 110n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4B.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50072199
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2,6-dimet...)
Show SMILES COc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C26H30N2O6/c1-30-23-12-21-22(13-24(23)32-8-7-29)27-26(31-2)28-25(21)18-9-19(33-14-16-3-4-16)11-20(10-18)34-15-17-5-6-17/h9-13,16-17,29H,3-8,14-15H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 130n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4A.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50072200
PNG
(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(OCCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C28H34N2O7/c1-33-25-14-23-24(15-26(25)34-10-8-32)29-28(35-9-2-7-31)30-27(23)20-11-21(36-16-18-3-4-18)13-22(12-20)37-17-19-5-6-19/h11-15,18-19,31-32H,2-10,16-17H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 130n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4D.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50072199
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2,6-dimet...)
Show SMILES COc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C26H30N2O6/c1-30-23-12-21-22(13-24(23)32-8-7-29)27-26(31-2)28-25(21)18-9-19(33-14-16-3-4-16)11-20(10-18)34-15-17-5-6-17/h9-13,16-17,29H,3-8,14-15H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 140n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4D.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT-Rattus norvegicus)
BDBM50072200
PNG
(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(OCCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C28H34N2O7/c1-33-25-14-23-24(15-26(25)34-10-8-32)29-28(35-9-2-7-31)30-27(23)20-11-21(36-16-18-3-4-18)13-22(12-20)37-17-19-5-6-19/h11-15,18-19,31-32H,2-10,16-17H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 145n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL




Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT)
BDBM50072200
PNG
(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(OCCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C28H34N2O7/c1-33-25-14-23-24(15-26(25)34-10-8-32)29-28(35-9-2-7-31)30-27(23)20-11-21(36-16-18-3-4-18)13-22(12-20)37-17-19-5-6-19/h11-15,18-19,31-32H,2-10,16-17H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 200n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4B.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT-Rattus norvegicus)
BDBM50072209
PNG
(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(NCCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C28H35N3O6/c1-34-25-14-23-24(15-26(25)35-10-9-33)30-28(29-7-2-8-32)31-27(23)20-11-21(36-16-18-3-4-18)13-22(12-20)37-17-19-5-6-19/h11-15,18-19,32-33H,2-10,16-17H2,1H3,(H,29,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 200n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL




Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT-Rattus norvegicus)
BDBM50072199
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2,6-dimet...)
Show SMILES COc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C26H30N2O6/c1-30-23-12-21-22(13-24(23)32-8-7-29)27-26(31-2)28-25(21)18-9-19(33-14-16-3-4-16)11-20(10-18)34-15-17-5-6-17/h9-13,16-17,29H,3-8,14-15H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 210n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL




Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50072209
PNG
(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(NCCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C28H35N3O6/c1-34-25-14-23-24(15-26(25)35-10-9-33)30-28(29-7-2-8-32)31-27(23)20-11-21(36-16-18-3-4-18)13-22(12-20)37-17-19-5-6-19/h11-15,18-19,32-33H,2-10,16-17H2,1H3,(H,29,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 230n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4D.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50072200
PNG
(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(OCCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C28H34N2O7/c1-33-25-14-23-24(15-26(25)34-10-8-32)29-28(35-9-2-7-31)30-27(23)20-11-21(36-16-18-3-4-18)13-22(12-20)37-17-19-5-6-19/h11-15,18-19,31-32H,2-10,16-17H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 250n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4A.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50072194
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-butyl-6...)
Show SMILES CCCCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C29H36N2O5/c1-3-4-5-28-30-25-16-27(34-11-10-32)26(33-2)15-24(25)29(31-28)21-12-22(35-17-19-6-7-19)14-23(13-21)36-18-20-8-9-20/h12-16,19-20,32H,3-11,17-18H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 300n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4D.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT)
BDBM50072194
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-butyl-6...)
Show SMILES CCCCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C29H36N2O5/c1-3-4-5-28-30-25-16-27(34-11-10-32)26(33-2)15-24(25)29(31-28)21-12-22(35-17-19-6-7-19)14-23(13-21)36-18-20-8-9-20/h12-16,19-20,32H,3-11,17-18H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 300n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4B.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50072200
PNG
(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(OCCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C28H34N2O7/c1-33-25-14-23-24(15-26(25)34-10-8-32)29-28(35-9-2-7-31)30-27(23)20-11-21(36-16-18-3-4-18)13-22(12-20)37-17-19-5-6-19/h11-15,18-19,31-32H,2-10,16-17H2,1H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 310n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL




Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT)
BDBM50072209
PNG
(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(NCCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C28H35N3O6/c1-34-25-14-23-24(15-26(25)35-10-9-33)30-28(29-7-2-8-32)31-27(23)20-11-21(36-16-18-3-4-18)13-22(12-20)37-17-19-5-6-19/h11-15,18-19,32-33H,2-10,16-17H2,1H3,(H,29,30,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 340n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4B.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50072195
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethoxy-...)
Show SMILES CCOc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C27H32N2O6/c1-3-32-27-28-23-14-25(33-9-8-30)24(31-2)13-22(23)26(29-27)19-10-20(34-15-17-4-5-17)12-21(11-19)35-16-18-6-7-18/h10-14,17-18,30H,3-9,15-16H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 340n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL




Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50072199
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2,6-dimet...)
Show SMILES COc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C26H30N2O6/c1-30-23-12-21-22(13-24(23)32-8-7-29)27-26(31-2)28-25(21)18-9-19(33-14-16-3-4-16)11-20(10-18)34-15-17-5-6-17/h9-13,16-17,29H,3-8,14-15H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 390n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL




Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50072209
PNG
(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(NCCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C28H35N3O6/c1-34-25-14-23-24(15-26(25)35-10-9-33)30-28(29-7-2-8-32)31-27(23)20-11-21(36-16-18-3-4-18)13-22(12-20)37-17-19-5-6-19/h11-15,18-19,32-33H,2-10,16-17H2,1H3,(H,29,30,31)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 430n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL




Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50072211
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(OCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C27H32N2O7/c1-32-24-13-22-23(14-25(24)33-8-6-30)28-27(34-9-7-31)29-26(22)19-10-20(35-15-17-2-3-17)12-21(11-19)36-16-18-4-5-18/h10-14,17-18,30-31H,2-9,15-16H2,1H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 430n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL




Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT)
BDBM50072204
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethylsu...)
Show SMILES CCSc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C27H32N2O5S/c1-3-35-27-28-23-14-25(32-9-8-30)24(31-2)13-22(23)26(29-27)19-10-20(33-15-17-4-5-17)12-21(11-19)34-16-18-6-7-18/h10-14,17-18,30H,3-9,15-16H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 440n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4B.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50072209
PNG
(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(NCCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C28H35N3O6/c1-34-25-14-23-24(15-26(25)35-10-9-33)30-28(29-7-2-8-32)31-27(23)20-11-21(36-16-18-3-4-18)13-22(12-20)37-17-19-5-6-19/h11-15,18-19,32-33H,2-10,16-17H2,1H3,(H,29,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 500n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4A.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50072205
PNG
(4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-cyclopropy...)
Show SMILES CCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCC3CC3)cc2n1
Show InChI InChI=1S/C29H34N2O4/c1-3-28-30-25-14-27(35-17-20-8-9-20)26(32-2)13-24(25)29(31-28)21-10-22(33-15-18-4-5-18)12-23(11-21)34-16-19-6-7-19/h10-14,18-20H,3-9,15-17H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 540n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4D.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50072204
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethylsu...)
Show SMILES CCSc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C27H32N2O5S/c1-3-35-27-28-23-14-25(32-9-8-30)24(31-2)13-22(23)26(29-27)19-10-20(33-15-17-4-5-17)12-21(11-19)34-16-18-6-7-18/h10-14,17-18,30H,3-9,15-16H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 540n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4A.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT)
BDBM50072205
PNG
(4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-cyclopropy...)
Show SMILES CCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCC3CC3)cc2n1
Show InChI InChI=1S/C29H34N2O4/c1-3-28-30-25-14-27(35-17-20-8-9-20)26(32-2)13-24(25)29(31-28)21-10-22(33-15-18-4-5-18)12-23(11-21)34-16-19-6-7-19/h10-14,18-20H,3-9,15-17H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 600n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4B.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50072212
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-q...)
Show SMILES CCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2ccc(OCCO)cc2n1
Show InChI InChI=1S/C26H30N2O4/c1-2-25-27-24-14-20(30-10-9-29)7-8-23(24)26(28-25)19-11-21(31-15-17-3-4-17)13-22(12-19)32-16-18-5-6-18/h7-8,11-14,17-18,29H,2-6,9-10,15-16H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 630n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4A.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50072210
PNG
(4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-6-me...)
Show SMILES CCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(O)cc2n1
Show InChI InChI=1S/C25H28N2O4/c1-3-24-26-21-12-22(28)23(29-2)11-20(21)25(27-24)17-8-18(30-13-15-4-5-15)10-19(9-17)31-14-16-6-7-16/h8-12,15-16,28H,3-7,13-14H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 650n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4D.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT)
BDBM50072206
PNG
(4-(3,5-Bis-cyclopropylmethoxy-phenyl)-6,7-dimethox...)
Show SMILES COc1cc2nc(C)nc(-c3cc(OCC4CC4)cc(OCC4CC4)c3)c2cc1OC
Show InChI InChI=1S/C25H28N2O4/c1-15-26-22-12-24(29-3)23(28-2)11-21(22)25(27-15)18-8-19(30-13-16-4-5-16)10-20(9-18)31-14-17-6-7-17/h8-12,16-17H,4-7,13-14H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 650n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4B.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT)
BDBM50072212
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-q...)
Show SMILES CCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2ccc(OCCO)cc2n1
Show InChI InChI=1S/C26H30N2O4/c1-2-25-27-24-14-20(30-10-9-29)7-8-23(24)26(28-25)19-11-21(31-15-17-3-4-17)13-22(12-19)32-16-18-5-6-18/h7-8,11-14,17-18,29H,2-6,9-10,15-16H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 660n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4B.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50072204
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethylsu...)
Show SMILES CCSc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C27H32N2O5S/c1-3-35-27-28-23-14-25(32-9-8-30)24(31-2)13-22(23)26(29-27)19-10-20(33-15-17-4-5-17)12-21(11-19)34-16-18-6-7-18/h10-14,17-18,30H,3-9,15-16H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 700n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4D.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50072207
PNG
(CHEMBL97213 | [4-(3,5-Bis-cyclopropylmethoxy-pheny...)
Show SMILES CCOC(=O)COc1cc2nc(C)nc(-c3cc(OCC4CC4)cc(OCC4CC4)c3)c2cc1OC
Show InChI InChI=1S/C28H32N2O6/c1-4-33-27(31)16-36-26-13-24-23(12-25(26)32-3)28(30-17(2)29-24)20-9-21(34-14-18-5-6-18)11-22(10-20)35-15-19-7-8-19/h9-13,18-19H,4-8,14-16H2,1-3H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 700n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL




Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50072194
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-butyl-6...)
Show SMILES CCCCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C29H36N2O5/c1-3-4-5-28-30-25-16-27(34-11-10-32)26(33-2)15-24(25)29(31-28)21-12-22(35-17-19-6-7-19)14-23(13-21)36-18-20-8-9-20/h12-16,19-20,32H,3-11,17-18H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 720n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL




Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50072206
PNG
(4-(3,5-Bis-cyclopropylmethoxy-phenyl)-6,7-dimethox...)
Show SMILES COc1cc2nc(C)nc(-c3cc(OCC4CC4)cc(OCC4CC4)c3)c2cc1OC
Show InChI InChI=1S/C25H28N2O4/c1-15-26-22-12-24(29-3)23(28-2)11-21(22)25(27-15)18-8-19(30-13-16-4-5-16)10-20(9-18)31-14-17-6-7-17/h8-12,16-17H,4-7,13-14H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 800n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4D.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50072212
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-q...)
Show SMILES CCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2ccc(OCCO)cc2n1
Show InChI InChI=1S/C26H30N2O4/c1-2-25-27-24-14-20(30-10-9-29)7-8-23(24)26(28-25)19-11-21(31-15-17-3-4-17)13-22(12-19)32-16-18-5-6-18/h7-8,11-14,17-18,29H,2-6,9-10,15-16H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 850n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4D.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50072206
PNG
(4-(3,5-Bis-cyclopropylmethoxy-phenyl)-6,7-dimethox...)
Show SMILES COc1cc2nc(C)nc(-c3cc(OCC4CC4)cc(OCC4CC4)c3)c2cc1OC
Show InChI InChI=1S/C25H28N2O4/c1-15-26-22-12-24(29-3)23(28-2)11-21(22)25(27-15)18-8-19(30-13-16-4-5-16)10-20(9-18)31-14-17-6-7-17/h8-12,16-17H,4-7,13-14H2,1-3H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 900n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4A.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50072198
PNG
(4-(3,5-Diisopropoxy-phenyl)-6,7-dimethoxy-2-methyl...)
Show SMILES COc1cc2nc(C)nc(-c3cc(OC(C)C)cc(OC(C)C)c3)c2cc1OC
Show InChI InChI=1S/C23H28N2O4/c1-13(2)28-17-8-16(9-18(10-17)29-14(3)4)23-19-11-21(26-6)22(27-7)12-20(19)24-15(5)25-23/h8-14H,1-7H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4D.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50072208
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-6-methoxy...)
Show SMILES COc1cc2c(nc(nc2cc1OCCO)N1CCOCC1)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C29H35N3O6/c1-34-26-15-24-25(16-27(26)36-11-8-33)30-29(32-6-9-35-10-7-32)31-28(24)21-12-22(37-17-19-2-3-19)14-23(13-21)38-18-20-4-5-20/h12-16,19-20,33H,2-11,17-18H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4D.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50072194
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-butyl-6...)
Show SMILES CCCCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C29H36N2O5/c1-3-4-5-28-30-25-16-27(34-11-10-32)26(33-2)15-24(25)29(31-28)21-12-22(35-17-19-6-7-19)14-23(13-21)36-18-20-8-9-20/h12-16,19-20,32H,3-11,17-18H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4A.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(RAT)
BDBM50072198
PNG
(4-(3,5-Diisopropoxy-phenyl)-6,7-dimethoxy-2-methyl...)
Show SMILES COc1cc2nc(C)nc(-c3cc(OC(C)C)cc(OC(C)C)c3)c2cc1OC
Show InChI InChI=1S/C23H28N2O4/c1-13(2)28-17-8-16(9-18(10-17)29-14(3)4)23-19-11-21(26-6)22(27-7)12-20(19)24-15(5)25-23/h8-14H,1-7H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE4B.


Bioorg Med Chem Lett 8: 2891-6 (1999)


BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 75 total )  |  Next  |  Last  >>
Jump to: