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Compile Data Set for Download or QSAR

Found 28 hits with Last Name = 'doukas' and Initial = 'p'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50450592
PNG
(CHEMBL558910)
Show SMILES OC(C(=O)O[C@H]1CN2CCC1CC2)(c1ccccc1)c1ccccc1 |r,wD:5.4,(8.38,-12.97,;7.3,-14.07,;8.63,-14.83,;8.64,-16.37,;9.97,-14.06,;11.3,-14.82,;11.3,-16.36,;12.63,-17.13,;13.96,-16.36,;13.96,-14.82,;12.63,-14.05,;13.05,-15.29,;12,-15.64,;5.97,-14.84,;4.63,-14.07,;3.3,-14.84,;3.31,-16.38,;4.65,-17.15,;5.98,-16.37,;7.29,-12.53,;8.62,-11.76,;8.62,-10.22,;7.28,-9.45,;5.95,-10.23,;5.96,-11.77,)|
Show InChI InChI=1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2/t19-/m0/s1
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0.0300n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50450592
PNG
(CHEMBL558910)
Show SMILES OC(C(=O)O[C@H]1CN2CCC1CC2)(c1ccccc1)c1ccccc1 |r,wD:5.4,(8.38,-12.97,;7.3,-14.07,;8.63,-14.83,;8.64,-16.37,;9.97,-14.06,;11.3,-14.82,;11.3,-16.36,;12.63,-17.13,;13.96,-16.36,;13.96,-14.82,;12.63,-14.05,;13.05,-15.29,;12,-15.64,;5.97,-14.84,;4.63,-14.07,;3.3,-14.84,;3.31,-16.38,;4.65,-17.15,;5.98,-16.37,;7.29,-12.53,;8.62,-11.76,;8.62,-10.22,;7.28,-9.45,;5.95,-10.23,;5.96,-11.77,)|
Show InChI InChI=1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2/t19-/m0/s1
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0.150n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]pirenzepine from muscarinic M1 receptor of rat cortex homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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5.20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]pirenzepine from muscarinic M1 receptor of rat cortex homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50291598
PNG
(2-(4-Diethylamino-but-2-ynyl)-isoindole-1,3-dione ...)
Show SMILES CCN(CC)CC#CCN1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C16H18N2O2/c1-3-17(4-2)11-7-8-12-18-15(19)13-9-5-6-10-14(13)16(18)20/h5-6,9-10H,3-4,11-12H2,1-2H3
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30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]pirenzepine from muscarinic M1 receptor of rat cortex homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50291598
PNG
(2-(4-Diethylamino-but-2-ynyl)-isoindole-1,3-dione ...)
Show SMILES CCN(CC)CC#CCN1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C16H18N2O2/c1-3-17(4-2)11-7-8-12-18-15(19)13-9-5-6-10-14(13)16(18)20/h5-6,9-10H,3-4,11-12H2,1-2H3
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100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50291596
PNG
(1-(4-Diethylamino-but-2-ynyl)-3,3-diphenyl-pyrroli...)
Show SMILES CCN(CC)CC#CCN1C(=O)CC(C1=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H26N2O2/c1-3-25(4-2)17-11-12-18-26-22(27)19-24(23(26)28,20-13-7-5-8-14-20)21-15-9-6-10-16-21/h5-10,13-16H,3-4,17-19H2,1-2H3
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120n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]pirenzepine from muscarinic M1 receptor of rat cortex homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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267n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50291592
PNG
(3-(4-Diethylamino-but-2-ynyl)-5,5-diphenyl-imidazo...)
Show SMILES CCN(CC)CC#CCN1C(=O)NC(C1=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H25N3O2/c1-3-25(4-2)17-11-12-18-26-21(27)23(24-22(26)28,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5-10,13-16H,3-4,17-18H2,1-2H3,(H,24,28)
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380n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]pirenzepine from muscarinic M1 receptor of rat cortex homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50291596
PNG
(1-(4-Diethylamino-but-2-ynyl)-3,3-diphenyl-pyrroli...)
Show SMILES CCN(CC)CC#CCN1C(=O)CC(C1=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H26N2O2/c1-3-25(4-2)17-11-12-18-26-22(27)19-24(23(26)28,20-13-7-5-8-14-20)21-15-9-6-10-16-21/h5-10,13-16H,3-4,17-19H2,1-2H3
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380n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50291601
PNG
(1-(4-Diisopropylamino-but-2-ynyl)-3,3-diphenyl-pyr...)
Show SMILES CC(C)N(CC#CCN1C(=O)CC(C1=O)(c1ccccc1)c1ccccc1)C(C)C
Show InChI InChI=1S/C26H30N2O2/c1-20(2)27(21(3)4)17-11-12-18-28-24(29)19-26(25(28)30,22-13-7-5-8-14-22)23-15-9-6-10-16-23/h5-10,13-16,20-21H,17-19H2,1-4H3
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440n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50291591
PNG
(1'-(4-diethylamino-2-butynyl)spiro[10,11-dihydro-5...)
Show SMILES CCN(CC)CC#CCN1C(=O)CC2(C1=O)c1ccccc1CCc1ccccc21
Show InChI InChI=1S/C26H28N2O2/c1-3-27(4-2)17-9-10-18-28-24(29)19-26(25(28)30)22-13-7-5-11-20(22)15-16-21-12-6-8-14-23(21)26/h5-8,11-14H,3-4,15-19H2,1-2H3
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460n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]pirenzepine from muscarinic M1 receptor of rat cortex homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50291601
PNG
(1-(4-Diisopropylamino-but-2-ynyl)-3,3-diphenyl-pyr...)
Show SMILES CC(C)N(CC#CCN1C(=O)CC(C1=O)(c1ccccc1)c1ccccc1)C(C)C
Show InChI InChI=1S/C26H30N2O2/c1-20(2)27(21(3)4)17-11-12-18-28-24(29)19-26(25(28)30,22-13-7-5-8-14-22)23-15-9-6-10-16-23/h5-10,13-16,20-21H,17-19H2,1-4H3
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530n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]pirenzepine from muscarinic M1 receptor of rat cortex homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50291600
PNG
(5,5-Diphenyl-3-(4-pyrrolidin-1-yl-but-2-ynyl)-imid...)
Show SMILES O=C1NC(C(=O)N1CC#CCN1CCCC1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H23N3O2/c27-21-23(19-11-3-1-4-12-19,20-13-5-2-6-14-20)24-22(28)26(21)18-10-9-17-25-15-7-8-16-25/h1-6,11-14H,7-8,15-18H2,(H,24,28)
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640n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]pirenzepine from muscarinic M1 receptor of rat cortex homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50291602
PNG
(1'-(4-diethylamino-2-butynyl)spiro[2,3-dihydro-1H-...)
Show SMILES CCN(CC)CC#CCN1C(=O)CC2(CCc3ccccc23)C1=O
Show InChI InChI=1S/C20H24N2O2/c1-3-21(4-2)13-7-8-14-22-18(23)15-20(19(22)24)12-11-16-9-5-6-10-17(16)20/h5-6,9-10H,3-4,11-15H2,1-2H3
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680n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]pirenzepine from muscarinic M1 receptor of rat cortex homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50291592
PNG
(3-(4-Diethylamino-but-2-ynyl)-5,5-diphenyl-imidazo...)
Show SMILES CCN(CC)CC#CCN1C(=O)NC(C1=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H25N3O2/c1-3-25(4-2)17-11-12-18-26-21(27)23(24-22(26)28,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5-10,13-16H,3-4,17-18H2,1-2H3,(H,24,28)
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950n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50291597
PNG
(1-(4-diethylamino-2-butynyl)spiro[tetrahydro-1H-im...)
Show SMILES CCN(CC)CC#CCN1C(=O)NC2(CCc3ccccc23)C1=O
Show InChI InChI=1S/C19H23N3O2/c1-3-21(4-2)13-7-8-14-22-17(23)19(20-18(22)24)12-11-15-9-5-6-10-16(15)19/h5-6,9-10H,3-4,11-14H2,1-2H3,(H,20,24)
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1.05E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]pirenzepine from muscarinic M1 receptor of rat cortex homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50291593
PNG
(1'-(4-tetrahydro-1H-1-pyrrolyl-2-butynyl)spiro[2,3...)
Show SMILES O=C1CC2(CCc3ccccc23)C(=O)N1CC#CCN1CCCC1
Show InChI InChI=1S/C20H22N2O2/c23-18-15-20(10-9-16-7-1-2-8-17(16)20)19(24)22(18)14-6-5-13-21-11-3-4-12-21/h1-2,7-8H,3-4,9-15H2
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1.59E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]pirenzepine from muscarinic M1 receptor of rat cortex homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50291595
PNG
(1'-(4-diisopropylamino-2-butynyl)spiro[9H-fluorene...)
Show SMILES CC(C)N(CC#CCN1C(=O)CC2(C1=O)c1ccccc1-c1ccccc21)C(C)C
Show InChI InChI=1S/C26H28N2O2/c1-18(2)27(19(3)4)15-9-10-16-28-24(29)17-26(25(28)30)22-13-7-5-11-20(22)21-12-6-8-14-23(21)26/h5-8,11-14,18-19H,15-17H2,1-4H3
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1.62E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]pirenzepine from muscarinic M1 receptor of rat cortex homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50291599
PNG
(1'-(4-diethylamino-2-butynyl)spiro[9H-fluorene-9,3...)
Show SMILES CCN(CC)CC#CCN1C(=O)CC2(C1=O)c1ccccc1-c1ccccc21
Show InChI InChI=1S/C24H24N2O2/c1-3-25(4-2)15-9-10-16-26-22(27)17-24(23(26)28)20-13-7-5-11-18(20)19-12-6-8-14-21(19)24/h5-8,11-14H,3-4,15-17H2,1-2H3
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1.63E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]pirenzepine from muscarinic M1 receptor of rat cortex homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50291591
PNG
(1'-(4-diethylamino-2-butynyl)spiro[10,11-dihydro-5...)
Show SMILES CCN(CC)CC#CCN1C(=O)CC2(C1=O)c1ccccc1CCc1ccccc21
Show InChI InChI=1S/C26H28N2O2/c1-3-27(4-2)17-9-10-18-28-24(29)19-26(25(28)30)22-13-7-5-11-20(22)15-16-21-12-6-8-14-23(21)26/h5-8,11-14H,3-4,15-19H2,1-2H3
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2.09E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50291594
PNG
(1-(4-Diethylamino-but-2-ynyl)-3-phenyl-pyrrolidine...)
Show SMILES CCN(CC)CC#CCN1C(=O)CC(C1=O)c1ccccc1
Show InChI InChI=1S/C18H22N2O2/c1-3-19(4-2)12-8-9-13-20-17(21)14-16(18(20)22)15-10-6-5-7-11-15/h5-7,10-11,16H,3-4,12-14H2,1-2H3
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2.30E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]pirenzepine from muscarinic M1 receptor of rat cortex homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50291602
PNG
(1'-(4-diethylamino-2-butynyl)spiro[2,3-dihydro-1H-...)
Show SMILES CCN(CC)CC#CCN1C(=O)CC2(CCc3ccccc23)C1=O
Show InChI InChI=1S/C20H24N2O2/c1-3-21(4-2)13-7-8-14-22-18(23)15-20(19(22)24)12-11-16-9-5-6-10-17(16)20/h5-6,9-10H,3-4,11-15H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50291600
PNG
(5,5-Diphenyl-3-(4-pyrrolidin-1-yl-but-2-ynyl)-imid...)
Show SMILES O=C1NC(C(=O)N1CC#CCN1CCCC1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H23N3O2/c27-21-23(19-11-3-1-4-12-19,20-13-5-2-6-14-20)24-22(28)26(21)18-10-9-17-25-15-7-8-16-25/h1-6,11-14H,7-8,15-18H2,(H,24,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50291599
PNG
(1'-(4-diethylamino-2-butynyl)spiro[9H-fluorene-9,3...)
Show SMILES CCN(CC)CC#CCN1C(=O)CC2(C1=O)c1ccccc1-c1ccccc21
Show InChI InChI=1S/C24H24N2O2/c1-3-25(4-2)15-9-10-16-26-22(27)17-24(23(26)28)20-13-7-5-11-18(20)19-12-6-8-14-21(19)24/h5-8,11-14H,3-4,15-17H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50291595
PNG
(1'-(4-diisopropylamino-2-butynyl)spiro[9H-fluorene...)
Show SMILES CC(C)N(CC#CCN1C(=O)CC2(C1=O)c1ccccc1-c1ccccc21)C(C)C
Show InChI InChI=1S/C26H28N2O2/c1-18(2)27(19(3)4)15-9-10-16-28-24(29)17-26(25(28)30)22-13-7-5-11-20(22)21-12-6-8-14-23(21)26/h5-8,11-14,18-19H,15-17H2,1-4H3
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50291593
PNG
(1'-(4-tetrahydro-1H-1-pyrrolyl-2-butynyl)spiro[2,3...)
Show SMILES O=C1CC2(CCc3ccccc23)C(=O)N1CC#CCN1CCCC1
Show InChI InChI=1S/C20H22N2O2/c23-18-15-20(10-9-16-7-1-2-8-17(16)20)19(24)22(18)14-6-5-13-21-11-3-4-12-21/h1-2,7-8H,3-4,9-15H2
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50291594
PNG
(1-(4-Diethylamino-but-2-ynyl)-3-phenyl-pyrrolidine...)
Show SMILES CCN(CC)CC#CCN1C(=O)CC(C1=O)c1ccccc1
Show InChI InChI=1S/C18H22N2O2/c1-3-19(4-2)12-8-9-13-20-17(21)14-16(18(20)22)15-10-6-5-7-11-15/h5-7,10-11,16H,3-4,12-14H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50291597
PNG
(1-(4-diethylamino-2-butynyl)spiro[tetrahydro-1H-im...)
Show SMILES CCN(CC)CC#CCN1C(=O)NC2(CCc3ccccc23)C1=O
Show InChI InChI=1S/C19H23N3O2/c1-3-21(4-2)13-7-8-14-22-17(23)19(20-18(22)24)12-11-15-9-5-6-10-16(15)19/h5-6,9-10H,3-4,11-14H2,1-2H3,(H,20,24)
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TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.


Bioorg Med Chem Lett 7: 979-984 (1997)


Article DOI: 10.1016/S0960-894X(97)00143-1
BindingDB Entry DOI: 10.7270/Q2N29XFM
More data for this
Ligand-Target Pair