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Compile Data Set for Download or QSAR

Found 251 hits with Last Name = 'dunn' and Initial = 'wj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50083672
PNG
(18-methyl-10-oxa-6,7,18-triazahexacyclo[9.9.1.01,9...)
Show SMILES CN1CCC23C4Oc5c2c(CC1C3(O)Cc1cn[nH]c41)ccc5O |TLB:13:12:8.9.10:1.3.2,THB:7:8:12:1.3.2,0:1:12:8.9.10|
Show InChI InChI=1S/C18H19N3O3/c1-21-5-4-17-13-9-2-3-11(22)15(13)24-16(17)14-10(8-19-20-14)7-18(17,23)12(21)6-9/h2-3,8,12,16,22-23H,4-7H2,1H3,(H,19,20)
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1.70n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity towards human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligand


Bioorg Med Chem Lett 9: 3375-80 (2000)


BindingDB Entry DOI: 10.7270/Q2XP7440
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50083671
PNG
(19-methyl-11-oxa-6,8,19-triazahexacyclo[10.9.1.01,...)
Show SMILES CN1CCC23C4Oc5c2c(CC1C3(O)Cc1cnc(=O)[nH]c41)ccc5O |TLB:13:12:8.9.10:1.3.2,THB:7:8:12:1.3.2,0:1:12:8.9.10|
Show InChI InChI=1S/C19H19N3O4/c1-22-5-4-18-13-9-2-3-11(23)15(13)26-16(18)14-10(8-20-17(24)21-14)7-19(18,25)12(22)6-9/h2-3,8,12,16,23,25H,4-7H2,1H3,(H,20,21,24)
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3.80n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity towards human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligand


Bioorg Med Chem Lett 9: 3375-80 (2000)


BindingDB Entry DOI: 10.7270/Q2XP7440
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50083668
PNG
(7,19-dimethyl-11-oxa-6,8,19-triazahexacyclo[10.9.1...)
Show SMILES CN1CCC23C4Oc5c2c(CC1C3(O)Cc1cnc(C)nc41)ccc5O |TLB:13:12:8.9.10:1.3.2,THB:7:8:12:1.3.2,0:1:12:8.9.10|
Show InChI InChI=1S/C20H21N3O3/c1-10-21-9-12-8-20(25)14-7-11-3-4-13(24)17-15(11)19(20,5-6-23(14)2)18(26-17)16(12)22-10/h3-4,9,14,18,24-25H,5-8H2,1-2H3
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5.30n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity towards human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligand


Bioorg Med Chem Lett 9: 3375-80 (2000)


BindingDB Entry DOI: 10.7270/Q2XP7440
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50083670
PNG
(19-methyl-7-phenyl-11-oxa-6,8,19-triazahexacyclo[1...)
Show SMILES CN1CCC23C4Oc5c2c(CC1C3(O)Cc1cnc(nc41)-c1ccccc1)ccc5O |TLB:13:12:8.9.10:1.3.2,THB:7:8:12:1.3.2,0:1:12:8.9.10|
Show InChI InChI=1S/C25H23N3O3/c1-28-10-9-24-19-15-7-8-17(29)21(19)31-22(24)20-16(12-25(24,30)18(28)11-15)13-26-23(27-20)14-5-3-2-4-6-14/h2-8,13,18,22,29-30H,9-12H2,1H3
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6.5n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity towards human opioid Delta receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-Cl-DPDPE as radioligand.


Bioorg Med Chem Lett 9: 3375-80 (2000)


BindingDB Entry DOI: 10.7270/Q2XP7440
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50083670
PNG
(19-methyl-7-phenyl-11-oxa-6,8,19-triazahexacyclo[1...)
Show SMILES CN1CCC23C4Oc5c2c(CC1C3(O)Cc1cnc(nc41)-c1ccccc1)ccc5O |TLB:13:12:8.9.10:1.3.2,THB:7:8:12:1.3.2,0:1:12:8.9.10|
Show InChI InChI=1S/C25H23N3O3/c1-28-10-9-24-19-15-7-8-17(29)21(19)31-22(24)20-16(12-25(24,30)18(28)11-15)13-26-23(27-20)14-5-3-2-4-6-14/h2-8,13,18,22,29-30H,9-12H2,1H3
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7.30n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity towards human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligand


Bioorg Med Chem Lett 9: 3375-80 (2000)


BindingDB Entry DOI: 10.7270/Q2XP7440
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50083669
PNG
(7-amino-19-methyl-11-oxa-6,8,19-triazahexacyclo[10...)
Show SMILES CN1CCC23C4Oc5c2c(CC1C3(O)Cc1cnc(N)nc41)ccc5O |TLB:13:12:8.9.10:1.3.2,THB:7:8:12:1.3.2,0:1:12:8.9.10|
Show InChI InChI=1S/C19H20N4O3/c1-23-5-4-18-13-9-2-3-11(24)15(13)26-16(18)14-10(8-21-17(20)22-14)7-19(18,25)12(23)6-9/h2-3,8,12,16,24-25H,4-7H2,1H3,(H2,20,21,22)
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7.30n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity towards human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligand


Bioorg Med Chem Lett 9: 3375-80 (2000)


BindingDB Entry DOI: 10.7270/Q2XP7440
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50083671
PNG
(19-methyl-11-oxa-6,8,19-triazahexacyclo[10.9.1.01,...)
Show SMILES CN1CCC23C4Oc5c2c(CC1C3(O)Cc1cnc(=O)[nH]c41)ccc5O |TLB:13:12:8.9.10:1.3.2,THB:7:8:12:1.3.2,0:1:12:8.9.10|
Show InChI InChI=1S/C19H19N3O4/c1-22-5-4-18-13-9-2-3-11(23)15(13)26-16(18)14-10(8-20-17(24)21-14)7-19(18,25)12(22)6-9/h2-3,8,12,16,23,25H,4-7H2,1H3,(H,20,21,24)
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12n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Agonistic activity against human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligand


Bioorg Med Chem Lett 9: 3375-80 (2000)


BindingDB Entry DOI: 10.7270/Q2XP7440
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50083672
PNG
(18-methyl-10-oxa-6,7,18-triazahexacyclo[9.9.1.01,9...)
Show SMILES CN1CCC23C4Oc5c2c(CC1C3(O)Cc1cn[nH]c41)ccc5O |TLB:13:12:8.9.10:1.3.2,THB:7:8:12:1.3.2,0:1:12:8.9.10|
Show InChI InChI=1S/C18H19N3O3/c1-21-5-4-17-13-9-2-3-11(22)15(13)24-16(17)14-10(8-19-20-14)7-18(17,23)12(21)6-9/h2-3,8,12,16,22-23H,4-7H2,1H3,(H,19,20)
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12n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Agonistic activity against human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligand


Bioorg Med Chem Lett 9: 3375-80 (2000)


BindingDB Entry DOI: 10.7270/Q2XP7440
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50083672
PNG
(18-methyl-10-oxa-6,7,18-triazahexacyclo[9.9.1.01,9...)
Show SMILES CN1CCC23C4Oc5c2c(CC1C3(O)Cc1cn[nH]c41)ccc5O |TLB:13:12:8.9.10:1.3.2,THB:7:8:12:1.3.2,0:1:12:8.9.10|
Show InChI InChI=1S/C18H19N3O3/c1-21-5-4-17-13-9-2-3-11(22)15(13)24-16(17)14-10(8-19-20-14)7-18(17,23)12(21)6-9/h2-3,8,12,16,22-23H,4-7H2,1H3,(H,19,20)
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12n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity towards human opioid Kappa receptor transfected into Chinese hamster ovary (CHO) cells using [3H]U69,593 as radioligand.


Bioorg Med Chem Lett 9: 3375-80 (2000)


BindingDB Entry DOI: 10.7270/Q2XP7440
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50083671
PNG
(19-methyl-11-oxa-6,8,19-triazahexacyclo[10.9.1.01,...)
Show SMILES CN1CCC23C4Oc5c2c(CC1C3(O)Cc1cnc(=O)[nH]c41)ccc5O |TLB:13:12:8.9.10:1.3.2,THB:7:8:12:1.3.2,0:1:12:8.9.10|
Show InChI InChI=1S/C19H19N3O4/c1-22-5-4-18-13-9-2-3-11(23)15(13)26-16(18)14-10(8-20-17(24)21-14)7-19(18,25)12(22)6-9/h2-3,8,12,16,23,25H,4-7H2,1H3,(H,20,21,24)
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19n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity towards human opioid Delta receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-Cl-DPDPE as radioligand.


Bioorg Med Chem Lett 9: 3375-80 (2000)


BindingDB Entry DOI: 10.7270/Q2XP7440
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50083669
PNG
(7-amino-19-methyl-11-oxa-6,8,19-triazahexacyclo[10...)
Show SMILES CN1CCC23C4Oc5c2c(CC1C3(O)Cc1cnc(N)nc41)ccc5O |TLB:13:12:8.9.10:1.3.2,THB:7:8:12:1.3.2,0:1:12:8.9.10|
Show InChI InChI=1S/C19H20N4O3/c1-23-5-4-18-13-9-2-3-11(24)15(13)26-16(18)14-10(8-21-17(20)22-14)7-19(18,25)12(23)6-9/h2-3,8,12,16,24-25H,4-7H2,1H3,(H2,20,21,22)
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19n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity towards human opioid Delta receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-Cl-DPDPE as radioligand.


Bioorg Med Chem Lett 9: 3375-80 (2000)


BindingDB Entry DOI: 10.7270/Q2XP7440
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50083669
PNG
(7-amino-19-methyl-11-oxa-6,8,19-triazahexacyclo[10...)
Show SMILES CN1CCC23C4Oc5c2c(CC1C3(O)Cc1cnc(N)nc41)ccc5O |TLB:13:12:8.9.10:1.3.2,THB:7:8:12:1.3.2,0:1:12:8.9.10|
Show InChI InChI=1S/C19H20N4O3/c1-23-5-4-18-13-9-2-3-11(24)15(13)26-16(18)14-10(8-21-17(20)22-14)7-19(18,25)12(23)6-9/h2-3,8,12,16,24-25H,4-7H2,1H3,(H2,20,21,22)
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21n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity towards human opioid Kappa receptor transfected into Chinese hamster ovary (CHO) cells using [3H]U69,593 as radioligand.


Bioorg Med Chem Lett 9: 3375-80 (2000)


BindingDB Entry DOI: 10.7270/Q2XP7440
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50083668
PNG
(7,19-dimethyl-11-oxa-6,8,19-triazahexacyclo[10.9.1...)
Show SMILES CN1CCC23C4Oc5c2c(CC1C3(O)Cc1cnc(C)nc41)ccc5O |TLB:13:12:8.9.10:1.3.2,THB:7:8:12:1.3.2,0:1:12:8.9.10|
Show InChI InChI=1S/C20H21N3O3/c1-10-21-9-12-8-20(25)14-7-11-3-4-13(24)17-15(11)19(20,5-6-23(14)2)18(26-17)16(12)22-10/h3-4,9,14,18,24-25H,5-8H2,1-2H3
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24n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity towards human opioid Delta receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-Cl-DPDPE as radioligand.


Bioorg Med Chem Lett 9: 3375-80 (2000)


BindingDB Entry DOI: 10.7270/Q2XP7440
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50083670
PNG
(19-methyl-7-phenyl-11-oxa-6,8,19-triazahexacyclo[1...)
Show SMILES CN1CCC23C4Oc5c2c(CC1C3(O)Cc1cnc(nc41)-c1ccccc1)ccc5O |TLB:13:12:8.9.10:1.3.2,THB:7:8:12:1.3.2,0:1:12:8.9.10|
Show InChI InChI=1S/C25H23N3O3/c1-28-10-9-24-19-15-7-8-17(29)21(19)31-22(24)20-16(12-25(24,30)18(28)11-15)13-26-23(27-20)14-5-3-2-4-6-14/h2-8,13,18,22,29-30H,9-12H2,1H3
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45n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity towards human opioid Kappa receptor transfected into Chinese hamster ovary (CHO) cells using [3H]U69,593 as radioligand.


Bioorg Med Chem Lett 9: 3375-80 (2000)


BindingDB Entry DOI: 10.7270/Q2XP7440
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50083668
PNG
(7,19-dimethyl-11-oxa-6,8,19-triazahexacyclo[10.9.1...)
Show SMILES CN1CCC23C4Oc5c2c(CC1C3(O)Cc1cnc(C)nc41)ccc5O |TLB:13:12:8.9.10:1.3.2,THB:7:8:12:1.3.2,0:1:12:8.9.10|
Show InChI InChI=1S/C20H21N3O3/c1-10-21-9-12-8-20(25)14-7-11-3-4-13(24)17-15(11)19(20,5-6-23(14)2)18(26-17)16(12)22-10/h3-4,9,14,18,24-25H,5-8H2,1-2H3
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69n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Agonistic activity against human opioid Delta receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-Cl-DPDPE as radioligand


Bioorg Med Chem Lett 9: 3375-80 (2000)


BindingDB Entry DOI: 10.7270/Q2XP7440
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50174850
PNG
(3-(9H-fluoren-2-yl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Show SMILES CN1C2CCC1C=C(C2)c1ccc-2c(Cc3ccccc-23)c1 |c:7,THB:9:7:1:3.4|
Show InChI InChI=1S/C21H21N/c1-22-18-7-8-19(22)13-16(12-18)14-6-9-21-17(10-14)11-15-4-2-3-5-20(15)21/h2-6,9-10,12,18-19H,7-8,11,13H2,1H3
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n/an/a 14.5n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Displacement of [3H]Citalopram from human SERT


Bioorg Med Chem Lett 15: 5488-93 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.082
BindingDB Entry DOI: 10.7270/Q20P0ZJ8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018304
PNG
(11-(2-{2-[(Cycloheptyl-methyl-amino)-methyl]-piper...)
Show SMILES CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12)C1CCCCCC1
Show InChI InChI=1S/C28H37N5O2/c1-31(21-11-4-2-3-5-12-21)19-22-13-8-9-18-32(22)20-26(34)33-25-16-7-6-14-23(25)28(35)30-24-15-10-17-29-27(24)33/h6-7,10,14-17,21-22H,2-5,8-9,11-13,18-20H2,1H3,(H,30,35)
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n/an/a 30n/an/an/an/an/an/a



College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018292
PNG
(11-[2-(2-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-4-28(5-2)16-19-9-6-7-14-29(19)17-23(31)30-22-12-11-18(3)15-20(22)25(32)27-21-10-8-13-26-24(21)30/h8,10-13,15,19H,4-7,9,14,16-17H2,1-3H3,(H,27,32)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018302
PNG
(9-Chloro-11-[2-(2-diethylaminomethyl-piperidin-1-y...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H30ClN5O2/c1-3-28(4-2)15-18-8-5-6-13-29(18)16-22(31)30-21-14-17(25)10-11-19(21)24(32)27-20-9-7-12-26-23(20)30/h7,9-12,14,18H,3-6,8,13,15-16H2,1-2H3,(H,27,32)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018056
PNG
((AF-DX 116) 11-[2-(2-Diethylaminomethyl-piperidin-...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018314
PNG
(11-(2-{2-[(Cyclohexyl-methyl-amino)-methyl]-piperi...)
Show SMILES CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12)C1CCCCC1
Show InChI InChI=1S/C27H35N5O2/c1-30(20-10-3-2-4-11-20)18-21-12-7-8-17-31(21)19-25(33)32-24-15-6-5-13-22(24)27(34)29-23-14-9-16-28-26(23)32/h5-6,9,13-16,20-21H,2-4,7-8,10-12,17-19H2,1H3,(H,29,34)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018291
PNG
(11-{2-[2-(3-Diethylamino-propyl)-piperidin-1-yl]-a...)
Show SMILES CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C26H35N5O2/c1-3-29(4-2)17-10-12-20-11-7-8-18-30(20)19-24(32)31-23-15-6-5-13-21(23)26(33)28-22-14-9-16-27-25(22)31/h5-6,9,13-16,20H,3-4,7-8,10-12,17-19H2,1-2H3,(H,28,33)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50018304
PNG
(11-(2-{2-[(Cycloheptyl-methyl-amino)-methyl]-piper...)
Show SMILES CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12)C1CCCCCC1
Show InChI InChI=1S/C28H37N5O2/c1-31(21-11-4-2-3-5-12-21)19-22-13-8-9-18-32(22)20-26(34)33-25-16-7-6-14-23(25)28(35)30-24-15-10-17-29-27(24)33/h6-7,10,14-17,21-22H,2-5,8-9,11-13,18-20H2,1H3,(H,30,35)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018294
PNG
(11-[2-(2-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-4-28(5-2)16-19-9-6-7-14-29(19)17-23(31)30-22-15-18(3)11-12-20(22)25(32)27-21-10-8-13-26-24(21)30/h8,10-13,15,19H,4-7,9,14,16-17H2,1-3H3,(H,27,32)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50174847
PNG
(3-(1H-indol-3-yl)-8-methyl-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CN1C2CCC1C=C(C2)c1c[nH]c2ccccc12 |c:7,THB:9:7:1:3.4|
Show InChI InChI=1S/C16H18N2/c1-18-12-6-7-13(18)9-11(8-12)15-10-17-16-5-3-2-4-14(15)16/h2-5,8,10,12-13,17H,6-7,9H2,1H3
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University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Displacement of [3H]Citalopram from human SERT


Bioorg Med Chem Lett 15: 5488-93 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.082
BindingDB Entry DOI: 10.7270/Q20P0ZJ8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018306
PNG
(8-Chloro-11-[2-(2-diethylaminomethyl-piperidin-1-y...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H30ClN5O2/c1-3-28(4-2)15-18-8-5-6-13-29(18)16-22(31)30-21-11-10-17(25)14-19(21)24(32)27-20-9-7-12-26-23(20)30/h7,9-12,14,18H,3-6,8,13,15-16H2,1-2H3,(H,27,32)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018298
PNG
(11-(2-{2-[(Butyl-methyl-amino)-methyl]-piperidin-1...)
Show SMILES CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-3-4-15-28(2)17-19-10-7-8-16-29(19)18-23(31)30-22-13-6-5-11-20(22)25(32)27-21-12-9-14-26-24(21)30/h5-6,9,11-14,19H,3-4,7-8,10,15-18H2,1-2H3,(H,27,32)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018293
PNG
(11-(2-{2-[(Ethyl-methyl-amino)-methyl]-piperidin-1...)
Show SMILES CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C23H29N5O2/c1-3-26(2)15-17-9-6-7-14-27(17)16-21(29)28-20-12-5-4-10-18(20)23(30)25-19-11-8-13-24-22(19)28/h4-5,8,10-13,17H,3,6-7,9,14-16H2,1-2H3,(H,25,30)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018297
PNG
(11-[2-(2-Dimethylaminomethyl-piperidin-1-yl)-acety...)
Show SMILES CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C22H27N5O2/c1-25(2)14-16-8-5-6-13-26(16)15-20(28)27-19-11-4-3-9-17(19)22(29)24-18-10-7-12-23-21(18)27/h3-4,7,9-12,16H,5-6,8,13-15H2,1-2H3,(H,24,29)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018056
PNG
((AF-DX 116) 11-[2-(2-Diethylaminomethyl-piperidin-...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018305
PNG
(8-Bromo-11-[2-(2-diethylaminomethyl-piperidin-1-yl...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H30BrN5O2/c1-3-28(4-2)15-18-8-5-6-13-29(18)16-22(31)30-21-11-10-17(25)14-19(21)24(32)27-20-9-7-12-26-23(20)30/h7,9-12,14,18H,3-6,8,13,15-16H2,1-2H3,(H,27,32)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50018314
PNG
(11-(2-{2-[(Cyclohexyl-methyl-amino)-methyl]-piperi...)
Show SMILES CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12)C1CCCCC1
Show InChI InChI=1S/C27H35N5O2/c1-30(20-10-3-2-4-11-20)18-21-12-7-8-17-31(21)19-25(33)32-24-15-6-5-13-22(24)27(34)29-23-14-9-16-28-26(23)32/h5-6,9,13-16,20-21H,2-4,7-8,10-12,17-19H2,1H3,(H,29,34)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018299
PNG
(11-[2-(2-Diethylaminomethyl-pyrrolidin-1-yl)-acety...)
Show SMILES CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C23H29N5O2/c1-3-26(4-2)15-17-9-8-14-27(17)16-21(29)28-20-12-6-5-10-18(20)23(30)25-19-11-7-13-24-22(19)28/h5-7,10-13,17H,3-4,8-9,14-16H2,1-2H3,(H,25,30)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018313
PNG
(11-[2-(3-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Show SMILES CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)C1
Show InChI InChI=1S/C24H31N5O2/c1-3-27(4-2)15-18-9-8-14-28(16-18)17-22(30)29-21-12-6-5-10-19(21)24(31)26-20-11-7-13-25-23(20)29/h5-7,10-13,18H,3-4,8-9,14-17H2,1-2H3,(H,26,31)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50018298
PNG
(11-(2-{2-[(Butyl-methyl-amino)-methyl]-piperidin-1...)
Show SMILES CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-3-4-15-28(2)17-19-10-7-8-16-29(19)18-23(31)30-22-13-6-5-11-20(22)25(32)27-21-12-9-14-26-24(21)30/h5-6,9,11-14,19H,3-4,7-8,10,15-18H2,1-2H3,(H,27,32)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50018291
PNG
(11-{2-[2-(3-Diethylamino-propyl)-piperidin-1-yl]-a...)
Show SMILES CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C26H35N5O2/c1-3-29(4-2)17-10-12-20-11-7-8-18-30(20)19-24(32)31-23-15-6-5-13-21(23)26(33)28-22-14-9-16-27-25(22)31/h5-6,9,13-16,20H,3-4,7-8,10-12,17-19H2,1-2H3,(H,28,33)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018296
PNG
(11-[2-(2-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(CC)cc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C26H35N5O2/c1-4-19-12-13-23-21(16-19)26(33)28-22-11-9-14-27-25(22)31(23)24(32)18-30-15-8-7-10-20(30)17-29(5-2)6-3/h9,11-14,16,20H,4-8,10,15,17-18H2,1-3H3,(H,28,33)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018300
PNG
(11-[3-(2-Diethylaminomethyl-piperidin-1-yl)-propio...)
Show SMILES CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-3-28(4-2)18-19-10-7-8-16-29(19)17-14-23(31)30-22-13-6-5-11-20(22)25(32)27-21-12-9-15-26-24(21)30/h5-6,9,11-13,15,19H,3-4,7-8,10,14,16-18H2,1-2H3,(H,27,32)
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n/an/a 220n/an/an/an/an/an/a



College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50018313
PNG
(11-[2-(3-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Show SMILES CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)C1
Show InChI InChI=1S/C24H31N5O2/c1-3-27(4-2)15-18-9-8-14-28(16-18)17-22(30)29-21-12-6-5-10-19(21)24(31)26-20-11-7-13-25-23(20)29/h5-7,10-13,18H,3-4,8-9,14-17H2,1-2H3,(H,26,31)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018307
PNG
(11-{2-[2-(2-Diethylamino-ethyl)-piperidin-1-yl]-ac...)
Show SMILES CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-3-28(4-2)17-14-19-10-7-8-16-29(19)18-23(31)30-22-13-6-5-11-20(22)25(32)27-21-12-9-15-26-24(21)30/h5-6,9,11-13,15,19H,3-4,7-8,10,14,16-18H2,1-2H3,(H,27,32)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM50174848
PNG
(3-(9H-fluoren-9-yl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Show SMILES CN1C2CCC1CC(O)(C2)C1c2ccccc2-c2ccccc12 |TLB:0:1:7.9.6:3.4,10:7:1:3.4,THB:8:7:1:3.4|
Show InChI InChI=1S/C21H23NO/c1-22-14-10-11-15(22)13-21(23,12-14)20-18-8-4-2-6-16(18)17-7-3-5-9-19(17)20/h2-9,14-15,20,23H,10-13H2,1H3
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n/an/a 543n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-35428 from human DAT


Bioorg Med Chem Lett 15: 5488-93 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.082
BindingDB Entry DOI: 10.7270/Q20P0ZJ8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018310
PNG
(11-[2-(2-Pyrrolidin-1-ylmethyl-piperidin-1-yl)-ace...)
Show SMILES O=C(CN1CCCCC1CN1CCCC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H29N5O2/c30-22(17-28-15-4-3-8-18(28)16-27-13-5-6-14-27)29-21-11-2-1-9-19(21)24(31)26-20-10-7-12-25-23(20)29/h1-2,7,9-12,18H,3-6,8,13-17H2,(H,26,31)
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n/an/a 560n/an/an/an/an/an/a



College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50018300
PNG
(11-[3-(2-Diethylaminomethyl-piperidin-1-yl)-propio...)
Show SMILES CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-3-28(4-2)18-19-10-7-8-16-29(19)17-14-23(31)30-22-13-6-5-11-20(22)25(32)27-21-12-9-15-26-24(21)30/h5-6,9,11-13,15,19H,3-4,7-8,10,14,16-18H2,1-2H3,(H,27,32)
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n/an/a 600n/an/an/an/an/an/a



College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018311
PNG
(11-[2-(2-Piperidin-1-ylmethyl-piperidin-1-yl)-acet...)
Show SMILES O=C(CN1CCCCC1CN1CCCCC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H31N5O2/c31-23(18-29-16-7-4-9-19(29)17-28-14-5-1-6-15-28)30-22-12-3-2-10-20(22)25(32)27-21-11-8-13-26-24(21)30/h2-3,8,10-13,19H,1,4-7,9,14-18H2,(H,27,32)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018301
PNG
(11-[2-(2-Ethylaminomethyl-piperidin-1-yl)-acetyl]-...)
Show SMILES CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C22H27N5O2/c1-2-23-14-16-8-5-6-13-26(16)15-20(28)27-19-11-4-3-9-17(19)22(29)25-18-10-7-12-24-21(18)27/h3-4,7,9-12,16,23H,2,5-6,8,13-15H2,1H3,(H,25,29)
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n/an/a 600n/an/an/an/an/an/a



College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM50174847
PNG
(3-(1H-indol-3-yl)-8-methyl-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CN1C2CCC1C=C(C2)c1c[nH]c2ccccc12 |c:7,THB:9:7:1:3.4|
Show InChI InChI=1S/C16H18N2/c1-18-12-6-7-13(18)9-11(8-12)15-10-17-16-5-3-2-4-14(15)16/h2-5,8,10,12-13,17H,6-7,9H2,1H3
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n/an/a 603n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-35428 from human DAT


Bioorg Med Chem Lett 15: 5488-93 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.082
BindingDB Entry DOI: 10.7270/Q20P0ZJ8
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50174849
PNG
(3-(biphenyl-3-yl)-8-methyl-8-azabicyclo[3.2.1]oct-...)
Show SMILES CN1C2CCC1C=C(C2)c1cccc(c1)-c1ccccc1 |c:7,THB:9:7:1:3.4|
Show InChI InChI=1S/C20H21N/c1-21-19-10-11-20(21)14-18(13-19)17-9-5-8-16(12-17)15-6-3-2-4-7-15/h2-9,12-13,19-20H,10-11,14H2,1H3
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n/an/a 670n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Displacement of [3H]Citalopram from human SERT


Bioorg Med Chem Lett 15: 5488-93 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.082
BindingDB Entry DOI: 10.7270/Q20P0ZJ8
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50174843
PNG
(3-(9H-fluoren-9-yl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Show SMILES CN1C2CCC1C=C(C2)C1c2ccccc2-c2ccccc12 |c:7,THB:9:7:1:3.4|
Show InChI InChI=1S/C21H21N/c1-22-15-10-11-16(22)13-14(12-15)21-19-8-4-2-6-17(19)18-7-3-5-9-20(18)21/h2-9,12,15-16,21H,10-11,13H2,1H3
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n/an/a 690n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Displacement of [3H]Citalopram from human SERT


Bioorg Med Chem Lett 15: 5488-93 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.082
BindingDB Entry DOI: 10.7270/Q20P0ZJ8
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM50174850
PNG
(3-(9H-fluoren-2-yl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Show SMILES CN1C2CCC1C=C(C2)c1ccc-2c(Cc3ccccc-23)c1 |c:7,THB:9:7:1:3.4|
Show InChI InChI=1S/C21H21N/c1-22-18-7-8-19(22)13-16(12-18)14-6-9-21-17(10-14)11-15-4-2-3-5-20(15)21/h2-6,9-10,12,18-19H,7-8,11,13H2,1H3
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n/an/a 757n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-35428 from human DAT


Bioorg Med Chem Lett 15: 5488-93 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.082
BindingDB Entry DOI: 10.7270/Q20P0ZJ8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50018312
PNG
(11-[2-(4-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Show SMILES CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C24H31N5O2/c1-3-27(4-2)16-18-11-14-28(15-12-18)17-22(30)29-21-10-6-5-8-19(21)24(31)26-20-9-7-13-25-23(20)29/h5-10,13,18H,3-4,11-12,14-17H2,1-2H3,(H,26,31)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of muscarinic (M2) receptor isolated from rat atria


J Med Chem 37: 3775-88 (1994)


BindingDB Entry DOI: 10.7270/Q2QC02JX
More data for this
Ligand-Target Pair
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