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Compile Data Set for Download or QSAR

Found 182 hits with Last Name = 'durand' and Initial = 'd'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161571
PNG
(US9108983, Example 386 | US9108983, Example 449)
Show SMILES Cc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C41H41ClN6O4/c1-26-36(41(51)48(31-10-12-34(49)13-11-31)38-21-32(23-43)44(3)27(38)2)22-39(45(26)4)37-20-30(42)9-14-35(37)40(50)47-24-29-8-6-5-7-28(29)19-33(47)25-46-15-17-52-18-16-46/h5-14,20-22,33,49H,15-19,24-25H2,1-4H3/t33-/m0/s1
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n/an/a 1.70n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161636
PNG
(US9108983, Example 455)
Show SMILES C[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(Cl)cc1-c1cc(C(=O)N(c2cc(C#N)n(CCN3CCOCC3)c2C)c2ccc(O)cc2)c(C)n1C
Show InChI InChI=1S/C42H43ClN6O4/c1-27-21-30-7-5-6-8-31(30)26-48(27)41(51)36-14-9-32(43)22-38(36)40-24-37(28(2)45(40)4)42(52)49(33-10-12-35(50)13-11-33)39-23-34(25-44)47(29(39)3)16-15-46-17-19-53-20-18-46/h5-14,22-24,27,50H,15-21,26H2,1-4H3/t27-/m1/s1
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n/an/a 1.90n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM60412
PNG
(US9108983, 445)
Show SMILES CN1C=CC2N=CC(=CC12)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1 |c:2,5,7|
Show InChI InChI=1S/C42H43ClN6O4/c1-27-36(42(52)49(31-9-11-34(50)12-10-31)32-22-40-38(44-24-32)14-15-45(40)2)23-39(46(27)3)37-21-30(43)8-13-35(37)41(51)48-25-29-7-5-4-6-28(29)20-33(48)26-47-16-18-53-19-17-47/h4-15,21-24,33,38,40,50H,16-20,25-26H2,1-3H3/t33-,38?,40?/m0/s1
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n/an/a 2n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161553
PNG
(US9108983, Example 102)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-c2cc(C(=O)N(c3ccc(O)cc3)c3cnc4n(C)ccc4c3)c(C)n2C)CC1
Show InChI InChI=1S/C43H44ClN7O3/c1-28-38(43(54)51(33-10-12-36(52)13-11-33)34-22-30-15-16-47(3)41(30)45-25-34)24-40(48(28)4)39-23-32(44)9-14-37(39)42(53)50-26-31-8-6-5-7-29(31)21-35(50)27-49-19-17-46(2)18-20-49/h5-16,22-25,35,52H,17-21,26-27H2,1-4H3/t35-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161578
PNG
(US9108983, Example 393)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CCCN2CCOCC2)n1C)C(=O)N(c1ccc(O)cc1)c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C44H45ClN6O4/c1-29-39(44(54)51(34-11-13-37(52)14-12-34)36-24-31-16-18-47(2)42(31)46-27-36)26-41(48(29)3)40-25-33(45)10-15-38(40)43(53)50-28-32-8-5-4-7-30(32)23-35(50)9-6-17-49-19-21-55-22-20-49/h4-5,7-8,10-16,18,24-27,35,52H,6,9,17,19-23,28H2,1-3H3/t35-/m1/s1
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n/an/a 2.10n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161536
PNG
(US9108983, Example 68)
Show SMILES C[C@@H]1Cc2ccccc2CN1C(=O)c1cc(O)c(F)cc1-c1cc(C(=O)N(c2cnn(C)c2)c2ccc(O)cc2)c(C)n1C
Show InChI InChI=1S/C34H32FN5O4/c1-20-13-22-7-5-6-8-23(22)18-39(20)33(43)29-16-32(42)30(35)14-28(29)31-15-27(21(2)38(31)4)34(44)40(25-17-36-37(3)19-25)24-9-11-26(41)12-10-24/h5-12,14-17,19-20,41-42H,13,18H2,1-4H3/t20-/m1/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161610
PNG
(US9108983, Example 427)
Show SMILES COc1ccc(cc1C#N)N(C(=O)c1cc(-c2cc(F)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C42H40FN5O5/c1-27-37(42(51)48(32-9-12-35(49)13-10-32)33-11-15-40(52-3)30(21-33)24-44)23-39(45(27)2)38-22-31(43)8-14-36(38)41(50)47-25-29-7-5-4-6-28(29)20-34(47)26-46-16-18-53-19-17-46/h4-15,21-23,34,49H,16-20,25-26H2,1-3H3/t34-/m0/s1
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n/an/a 2.20n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161554
PNG
(US9108983, Example 108 | US9108983, Example 448)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1cc(C#N)n(C)c1)c1ccc(O)cc1
Show InChI InChI=1S/C40H39ClN6O4/c1-26-36(40(50)47(30-9-11-34(48)12-10-30)33-20-31(22-42)43(2)24-33)21-38(44(26)3)37-19-29(41)8-13-35(37)39(49)46-23-28-7-5-4-6-27(28)18-32(46)25-45-14-16-51-17-15-45/h4-13,19-21,24,32,48H,14-18,23,25H2,1-3H3/t32-/m0/s1
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n/an/a 2.40n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161579
PNG
(US9108983, Example 394)
Show SMILES CN1CCc2cc(cnc12)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CCCN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C44H47ClN6O4/c1-29-39(44(54)51(34-11-13-37(52)14-12-34)36-24-31-16-18-47(2)42(31)46-27-36)26-41(48(29)3)40-25-33(45)10-15-38(40)43(53)50-28-32-8-5-4-7-30(32)23-35(50)9-6-17-49-19-21-55-22-20-49/h4-5,7-8,10-15,24-27,35,52H,6,9,16-23,28H2,1-3H3/t35-/m1/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161639
PNG
(US9108983, Example 459)
Show SMILES CCn1c(C)c(cc1C#N)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C42H43ClN6O4/c1-5-47-28(3)39(22-33(47)24-44)49(32-11-13-35(50)14-12-32)42(52)37-23-40(45(4)27(37)2)38-21-31(43)10-15-36(38)41(51)48-25-30-9-7-6-8-29(30)20-34(48)26-46-16-18-53-19-17-46/h6-15,21-23,34,50H,5,16-20,25-26H2,1-4H3/t34-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161604
PNG
(US9108983, Example 421)
Show SMILES Cc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2cc(F)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C41H41FN6O4/c1-26-36(41(51)48(31-10-12-34(49)13-11-31)38-21-32(23-43)44(3)27(38)2)22-39(45(26)4)37-20-30(42)9-14-35(37)40(50)47-24-29-8-6-5-7-28(29)19-33(47)25-46-15-17-52-18-16-46/h5-14,20-22,33,49H,15-19,24-25H2,1-4H3/t33-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161571
PNG
(US9108983, Example 386 | US9108983, Example 449)
Show SMILES Cc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C41H41ClN6O4/c1-26-36(41(51)48(31-10-12-34(49)13-11-31)38-21-32(23-43)44(3)27(38)2)22-39(45(26)4)37-20-30(42)9-14-35(37)40(50)47-24-29-8-6-5-7-28(29)19-33(47)25-46-15-17-52-18-16-46/h5-14,20-22,33,49H,15-19,24-25H2,1-4H3/t33-/m0/s1
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n/an/a 2.60n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161616
PNG
(US9108983, Example 433)
Show SMILES Cc1c(cc(-c2ccccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1cc(C#N)n(C)c1)c1ccc(O)cc1
Show InChI InChI=1S/C40H40N6O4/c1-27-37(40(49)46(30-12-14-34(47)15-13-30)33-21-31(23-41)42(2)25-33)22-38(43(27)3)35-10-6-7-11-36(35)39(48)45-24-29-9-5-4-8-28(29)20-32(45)26-44-16-18-50-19-17-44/h4-15,21-22,25,32,47H,16-20,24,26H2,1-3H3/t32-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161623
PNG
(US9108983, Example 440)
Show SMILES COc1cc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)c(cc1F)-c1cc(C(=O)N(c2cc(C#N)n(C)c2C)c2ccc(O)cc2)c(C)n1C
Show InChI InChI=1S/C42H43FN6O5/c1-26-34(42(52)49(30-10-12-33(50)13-11-30)38-19-31(23-44)45(3)27(38)2)21-39(46(26)4)35-20-37(43)40(53-5)22-36(35)41(51)48-24-29-9-7-6-8-28(29)18-32(48)25-47-14-16-54-17-15-47/h6-13,19-22,32,50H,14-18,24-25H2,1-5H3/t32-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161631
PNG
(US9108983, Example 450)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1cc(nn1C)C#N)c1ccc(O)cc1
Show InChI InChI=1S/C39H38ClN7O4/c1-25-34(39(50)47(30-9-11-32(48)12-10-30)37-20-29(22-41)42-44(37)3)21-36(43(25)2)35-19-28(40)8-13-33(35)38(49)46-23-27-7-5-4-6-26(27)18-31(46)24-45-14-16-51-17-15-45/h4-13,19-21,31,48H,14-18,23-24H2,1-3H3/t31-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161637
PNG
(US9108983, Example 456)
Show SMILES C[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(Cl)cc1-c1cc(C(=O)N(c2ccc(O)cc2)c2cnc(OCCN3CCOCC3)nc2)c(C)n1C
Show InChI InChI=1S/C40H41ClN6O5/c1-26-20-28-6-4-5-7-29(28)25-46(26)38(49)34-13-8-30(41)21-36(34)37-22-35(27(2)44(37)3)39(50)47(31-9-11-33(48)12-10-31)32-23-42-40(43-24-32)52-19-16-45-14-17-51-18-15-45/h4-13,21-24,26,48H,14-20,25H2,1-3H3/t26-/m1/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161640
PNG
(US9108983, Example 460)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CCCN2CCOCC2)n1C)C(=O)N(c1cnn(c1)C1CCOC1)c1ccc(O)cc1
Show InChI InChI=1S/C43H47ClN6O5/c1-29-39(43(53)50(33-10-12-37(51)13-11-33)36-25-45-49(27-36)35-15-19-55-28-35)24-41(46(29)2)40-23-32(44)9-14-38(40)42(52)48-26-31-7-4-3-6-30(31)22-34(48)8-5-16-47-17-20-54-21-18-47/h3-4,6-7,9-14,23-25,27,34-35,51H,5,8,15-22,26,28H2,1-2H3/t34-,35?/m1/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161602
PNG
(US9108983, Example 419)
Show SMILES Cc1c(cc(-c2cc(F)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1ccc(O)cc1)c1cccc(c1)C#N
Show InChI InChI=1S/C41H38FN5O4/c1-27-37(41(50)47(32-11-13-35(48)14-12-32)33-9-5-6-28(20-33)24-43)23-39(44(27)2)38-22-31(42)10-15-36(38)40(49)46-25-30-8-4-3-7-29(30)21-34(46)26-45-16-18-51-19-17-45/h3-15,20,22-23,34,48H,16-19,21,25-26H2,1-2H3/t34-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161632
PNG
(US9108983, Example 451)
Show SMILES Cc1c(cc(-c2cc(F)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1ccc(O)cc1)c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C41H40FN7O4/c1-26-36(41(52)49(31-9-11-34(50)12-10-31)32-19-29-22-44-46(3)39(29)43-23-32)21-38(45(26)2)37-20-30(42)8-13-35(37)40(51)48-24-28-7-5-4-6-27(28)18-33(48)25-47-14-16-53-17-15-47/h4-13,19-23,33,50H,14-18,24-25H2,1-3H3/t33-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161494
PNG
(US9108983, Example 25 | US9108983, Example 416)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1cnn(C)c1)c1ccc(O)cc1
Show InChI InChI=1S/C38H39ClN6O4/c1-25-34(38(48)45(31-21-40-41(2)23-31)29-9-11-32(46)12-10-29)20-36(42(25)3)35-19-28(39)8-13-33(35)37(47)44-22-27-7-5-4-6-26(27)18-30(44)24-43-14-16-49-17-15-43/h4-13,19-21,23,30,46H,14-18,22,24H2,1-3H3/t30-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161513
PNG
(US9108983, Example 44)
Show SMILES Cc1c(cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1ccc(O)cc1)c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C43H42N6O6/c1-27-35(43(52)49(31-8-10-34(50)11-9-31)32-19-29-12-13-45(2)41(29)44-23-32)20-38(46(27)3)36-21-39-40(55-26-54-39)22-37(36)42(51)48-24-30-7-5-4-6-28(30)18-33(48)25-47-14-16-53-17-15-47/h4-13,19-23,33,50H,14-18,24-26H2,1-3H3/t33-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161600
PNG
(US9108983, Example 417)
Show SMILES COc1ccc(-c2cc(C(=O)N(c3cc(C#N)n(C)c3C)c3ccc(O)cc3)c(C)n2C)c(c1)C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1
Show InChI InChI=1S/C42H44N6O5/c1-27-37(42(51)48(31-10-12-34(49)13-11-31)39-21-32(24-43)44(3)28(39)2)23-40(45(27)4)36-15-14-35(52-5)22-38(36)41(50)47-25-30-9-7-6-8-29(30)20-33(47)26-46-16-18-53-19-17-46/h6-15,21-23,33,49H,16-20,25-26H2,1-5H3/t33-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161614
PNG
(US9108983, Example 431)
Show SMILES Cc1nn(C)cc1N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C39H41ClN6O4/c1-25-37(24-42(3)41-25)46(30-10-12-32(47)13-11-30)39(49)34-21-36(43(4)26(34)2)35-20-29(40)9-14-33(35)38(48)45-22-28-8-6-5-7-27(28)19-31(45)23-44-15-17-50-18-16-44/h5-14,20-21,24,31,47H,15-19,22-23H2,1-4H3/t31-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161625
PNG
(US9108983, Example 442)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1csc(c1)C#N)c1ccc(O)cc1
Show InChI InChI=1S/C39H36ClN5O4S/c1-25-35(39(48)45(29-8-10-32(46)11-9-29)31-19-33(21-41)50-24-31)20-37(42(25)2)36-18-28(40)7-12-34(36)38(47)44-22-27-6-4-3-5-26(27)17-30(44)23-43-13-15-49-16-14-43/h3-12,18-20,24,30,46H,13-17,22-23H2,1-2H3/t30-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161612
PNG
(US9108983, Example 429)
Show SMILES COc1cc(-c2cc(C(=O)N(c3cc(C#N)n(C)c3C)c3ccc(O)cc3)c(C)n2C)c(cc1F)C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1
Show InChI InChI=1S/C42H43FN6O5/c1-26-34(42(52)49(30-10-12-33(50)13-11-30)38-19-31(23-44)45(3)27(38)2)21-39(46(26)4)35-22-40(53-5)37(43)20-36(35)41(51)48-24-29-9-7-6-8-28(29)18-32(48)25-47-14-16-54-17-15-47/h6-13,19-22,32,50H,14-18,24-25H2,1-5H3/t32-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161597
PNG
(US9108983, Example 413)
Show SMILES Cc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2cc3OCCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C43H44N6O6/c1-27-35(43(52)49(31-9-11-34(50)12-10-31)38-20-32(24-44)45(3)28(38)2)21-39(46(27)4)36-22-40-41(55-18-17-54-40)23-37(36)42(51)48-25-30-8-6-5-7-29(30)19-33(48)26-47-13-15-53-16-14-47/h5-12,20-23,33,50H,13-19,25-26H2,1-4H3/t33-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161596
PNG
(US9108983, Example 412)
Show SMILES Cc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CCCN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C43H45ClN6O4/c1-28-38(43(53)50(33-12-14-36(51)15-13-33)40-24-35(26-45)46(3)29(40)2)25-41(47(28)4)39-23-32(44)11-16-37(39)42(52)49-27-31-9-6-5-8-30(31)22-34(49)10-7-17-48-18-20-54-21-19-48/h5-6,8-9,11-16,23-25,34,51H,7,10,17-22,27H2,1-4H3/t34-/m1/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161641
PNG
(US9108983, Example 461)
Show SMILES Cc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CCCN2CCOCC2)n(C)c1C)c1ccccc1
Show InChI InChI=1S/C43H45ClN6O3/c1-29-38(43(52)50(34-13-6-5-7-14-34)40-25-36(27-45)46(3)30(40)2)26-41(47(29)4)39-24-33(44)16-17-37(39)42(51)49-28-32-12-9-8-11-31(32)23-35(49)15-10-18-48-19-21-53-22-20-48/h5-9,11-14,16-17,24-26,35H,10,15,18-23,28H2,1-4H3/t35-/m1/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161615
PNG
(US9108983, Example 432)
Show SMILES Cc1c(cnn1C)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C39H41ClN6O4/c1-25-34(39(49)46(30-10-12-32(47)13-11-30)37-22-41-43(4)26(37)2)21-36(42(25)3)35-20-29(40)9-14-33(35)38(48)45-23-28-8-6-5-7-27(28)19-31(45)24-44-15-17-50-18-16-44/h5-14,20-22,31,47H,15-19,23-24H2,1-4H3/t31-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161558
PNG
(US9108983, Example 116)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCN3CCOC[C@H]3C2)n1C)C(=O)N(c1cnn(C)c1)c1ccc(O)cc1
Show InChI InChI=1S/C41H44ClN7O4/c1-27-37(41(52)49(33-21-43-44(2)23-33)31-9-11-35(50)12-10-31)20-39(45(27)3)38-19-30(42)8-13-36(38)40(51)48-22-29-7-5-4-6-28(29)18-32(48)24-46-14-15-47-16-17-53-26-34(47)25-46/h4-13,19-21,23,32,34,50H,14-18,22,24-26H2,1-3H3/t32-,34+/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161559
PNG
(US9108983, Example 122)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1cnn(c1)C1CC1)c1ccc(O)cc1
Show InChI InChI=1S/C40H41ClN6O4/c1-26-36(40(50)47(31-10-12-34(48)13-11-31)33-22-42-46(25-33)30-8-9-30)21-38(43(26)2)37-20-29(41)7-14-35(37)39(49)45-23-28-6-4-3-5-27(28)19-32(45)24-44-15-17-51-18-16-44/h3-7,10-14,20-22,25,30,32,48H,8-9,15-19,23-24H2,1-2H3/t32-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161580
PNG
(US9108983, Example 395)
Show SMILES COc1ccc(cc1C#N)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C42H40ClN5O5/c1-27-37(42(51)48(32-9-12-35(49)13-10-32)33-11-15-40(52-3)30(21-33)24-44)23-39(45(27)2)38-22-31(43)8-14-36(38)41(50)47-25-29-7-5-4-6-28(29)20-34(47)26-46-16-18-53-19-17-46/h4-15,21-23,34,49H,16-20,25-26H2,1-3H3/t34-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161624
PNG
(US9108983, Example 441)
Show SMILES Cc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccccc1
Show InChI InChI=1S/C41H41ClN6O3/c1-27-36(41(50)48(32-12-6-5-7-13-32)38-22-33(24-43)44(3)28(38)2)23-39(45(27)4)37-21-31(42)14-15-35(37)40(49)47-25-30-11-9-8-10-29(30)20-34(47)26-46-16-18-51-19-17-46/h5-15,21-23,34H,16-20,25-26H2,1-4H3/t34-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161617
PNG
(US9108983, Example 434)
Show SMILES CN1CCc2cc(cnc12)N(C(=O)c1cc(-c2cc(F)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C42H43FN6O4/c1-27-37(42(52)49(32-9-11-35(50)12-10-32)33-21-29-14-15-45(2)40(29)44-24-33)23-39(46(27)3)38-22-31(43)8-13-36(38)41(51)48-25-30-7-5-4-6-28(30)20-34(48)26-47-16-18-53-19-17-47/h4-13,21-24,34,50H,14-20,25-26H2,1-3H3/t34-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161611
PNG
(US9108983, Example 428)
Show SMILES Cc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2ccc(F)cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C41H41FN6O4/c1-26-36(41(51)48(31-10-12-34(49)13-11-31)38-21-32(23-43)44(3)27(38)2)22-39(45(26)4)35-14-9-30(42)20-37(35)40(50)47-24-29-8-6-5-7-28(29)19-33(47)25-46-15-17-52-18-16-46/h5-14,20-22,33,49H,15-19,24-25H2,1-4H3/t33-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161557
PNG
(US9108983, Example 115)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCN3CCOC[C@@H]3C2)n1C)C(=O)N(c1cnn(C)c1)c1ccc(O)cc1
Show InChI InChI=1S/C41H44ClN7O4/c1-27-37(41(52)49(33-21-43-44(2)23-33)31-9-11-35(50)12-10-31)20-39(45(27)3)38-19-30(42)8-13-36(38)40(51)48-22-29-7-5-4-6-28(29)18-32(48)24-46-14-15-47-16-17-53-26-34(47)25-46/h4-13,19-21,23,32,34,50H,14-18,22,24-26H2,1-3H3/t32-,34-/m0/s1
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n/an/a 3.60n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161573
PNG
(US9108983, Example 388 | US9108984, 2)
Show SMILES CN1CCc2cc(cnc12)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C42H43ClN6O4/c1-27-37(42(52)49(32-9-11-35(50)12-10-32)33-21-29-14-15-45(2)40(29)44-24-33)23-39(46(27)3)38-22-31(43)8-13-36(38)41(51)48-25-30-7-5-4-6-28(30)20-34(48)26-47-16-18-53-19-17-47/h4-13,21-24,34,50H,14-20,25-26H2,1-3H3/t34-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161492
PNG
(US9108983, Example 23)
Show SMILES C[C@@H]1Cc2ccccc2CN1C(=O)c1cc2OCOc2cc1-c1cc(C(=O)N(c2cnn(C)c2)c2ccc(O)cc2)c(C)n1CCO
Show InChI InChI=1S/C36H35N5O6/c1-22-14-24-6-4-5-7-25(24)19-40(22)35(44)31-17-34-33(46-21-47-34)16-30(31)32-15-29(23(2)39(32)12-13-42)36(45)41(27-18-37-38(3)20-27)26-8-10-28(43)11-9-26/h4-11,15-18,20,22,42-43H,12-14,19,21H2,1-3H3/t22-/m1/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM51910
PNG
(US9108983, 14)
Show SMILES Cc1c(cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1ccc(O)cc1)c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C44H43N5O6/c1-28-36(44(52)49(32-8-11-35(50)12-9-32)33-10-13-39-30(21-33)14-15-45(39)2)22-40(46(28)3)37-23-41-42(55-27-54-41)24-38(37)43(51)48-25-31-7-5-4-6-29(31)20-34(48)26-47-16-18-53-19-17-47/h4-15,21-24,34,50H,16-20,25-27H2,1-3H3/t34-/m0/s1
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n/an/a 3.70n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161577
PNG
(US9108983, Example 392)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CCCN2CCOCC2)n1C)C(=O)N(c1ccccc1)c1ccc(O)cc1
Show InChI InChI=1S/C42H43ClN4O4/c1-29-38(42(50)47(33-11-4-3-5-12-33)34-15-17-36(48)18-16-34)27-40(44(29)2)39-26-32(43)14-19-37(39)41(49)46-28-31-10-7-6-9-30(31)25-35(46)13-8-20-45-21-23-51-24-22-45/h3-7,9-12,14-19,26-27,35,48H,8,13,20-25,28H2,1-2H3/t35-/m1/s1
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n/an/a 3.80n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161598
PNG
(US9108983, Example 415)
Show SMILES Cc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1)c1ccc(O)cc1
Show InChI InChI=1S/C40H39ClN6O4/c1-26-37(21-32(22-42)44(26)3)47(31-9-11-34(48)12-10-31)39(49)29-19-38(43(2)23-29)36-20-30(41)8-13-35(36)40(50)46-24-28-7-5-4-6-27(28)18-33(46)25-45-14-16-51-17-15-45/h4-13,19-21,23,33,48H,14-18,24-25H2,1-3H3/t33-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161583
PNG
(US9108983, Example 398)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1ccc(O)cc1)c1cccc(c1)C#N
Show InChI InChI=1S/C41H38ClN5O4/c1-27-37(41(50)47(32-11-13-35(48)14-12-32)33-9-5-6-28(20-33)24-43)23-39(44(27)2)38-22-31(42)10-15-36(38)40(49)46-25-30-8-4-3-7-29(30)21-34(46)26-45-16-18-51-19-17-45/h3-15,20,22-23,34,48H,16-19,21,25-26H2,1-2H3/t34-/m0/s1
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n/an/a 3.90n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161554
PNG
(US9108983, Example 108 | US9108983, Example 448)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1cc(C#N)n(C)c1)c1ccc(O)cc1
Show InChI InChI=1S/C40H39ClN6O4/c1-26-36(40(50)47(30-9-11-34(48)12-10-30)33-20-31(22-42)43(2)24-33)21-38(44(26)3)37-19-29(41)8-13-35(37)39(49)46-23-28-7-5-4-6-27(28)18-32(46)25-45-14-16-51-17-15-45/h4-13,19-21,24,32,48H,14-18,23,25H2,1-3H3/t32-/m0/s1
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n/an/a 3.90n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161488
PNG
(US9108983, Example 18)
Show SMILES Cc1c(cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CCN2CCOCC2)n1CCO)C(=O)N(c1ccccc1)c1ccc(O)cc1
Show InChI InChI=1S/C43H44N4O7/c1-29-36(43(51)47(32-9-3-2-4-10-32)33-11-13-35(49)14-12-33)24-39(45(29)17-20-48)37-25-40-41(54-28-53-40)26-38(37)42(50)46-27-31-8-6-5-7-30(31)23-34(46)15-16-44-18-21-52-22-19-44/h2-14,24-26,34,48-49H,15-23,27-28H2,1H3/t34-/m1/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161494
PNG
(US9108983, Example 25 | US9108983, Example 416)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1cnn(C)c1)c1ccc(O)cc1
Show InChI InChI=1S/C38H39ClN6O4/c1-25-34(38(48)45(31-21-40-41(2)23-31)29-9-11-32(46)12-10-29)20-36(42(25)3)35-19-28(39)8-13-33(35)37(47)44-22-27-7-5-4-6-26(27)18-30(44)24-43-14-16-49-17-15-43/h4-13,19-21,23,30,46H,14-18,22,24H2,1-3H3/t30-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161518
PNG
(US9108983, Example 49)
Show SMILES CN1CCc2cc(cnc12)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C43H44N6O6/c1-27-35(43(52)49(31-8-10-34(50)11-9-31)32-19-29-12-13-45(2)41(29)44-23-32)20-38(46(27)3)36-21-39-40(55-26-54-39)22-37(36)42(51)48-24-30-7-5-4-6-28(30)18-33(48)25-47-14-16-53-17-15-47/h4-11,19-23,33,50H,12-18,24-26H2,1-3H3/t33-/m0/s1
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LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161495
PNG
(US9108983, Example 26)
Show SMILES CNCCn1c(C)c(cc1-c1cc2OCOc2cc1C(=O)N1Cc2ccccc2C[C@H]1C)C(=O)N(c1cnn(C)c1)c1ccc(O)cc1
Show InChI InChI=1S/C37H38N6O5/c1-23-15-25-7-5-6-8-26(25)20-42(23)36(45)32-18-35-34(47-22-48-35)17-31(32)33-16-30(24(2)41(33)14-13-38-3)37(46)43(28-19-39-40(4)21-28)27-9-11-29(44)12-10-27/h5-12,16-19,21,23,38,44H,13-15,20,22H2,1-4H3/t23-/m1/s1
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n/an/a 4.10n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161608
PNG
(US9108983, Example 425)
Show SMILES COc1cc(cc(c1)N(C(=O)c1cc(-c2cc(F)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1)C#N
Show InChI InChI=1S/C42H40FN5O5/c1-27-38(42(51)48(32-9-11-35(49)12-10-32)33-18-28(24-44)19-36(22-33)52-3)23-40(45(27)2)39-21-31(43)8-13-37(39)41(50)47-25-30-7-5-4-6-29(30)20-34(47)26-46-14-16-53-17-15-46/h4-13,18-19,21-23,34,49H,14-17,20,25-26H2,1-3H3/t34-/m0/s1
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n/an/a 4.20n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161590
PNG
(US9108983, Example 406)
Show SMILES Cc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2ccccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C41H42N6O4/c1-27-37(41(50)47(31-13-15-34(48)16-14-31)38-22-32(24-42)43(3)28(38)2)23-39(44(27)4)35-11-7-8-12-36(35)40(49)46-25-30-10-6-5-9-29(30)21-33(46)26-45-17-19-51-20-18-45/h5-16,22-23,33,48H,17-21,25-26H2,1-4H3/t33-/m0/s1
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US Patent
n/an/a 4.20n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161560
PNG
(US9108983, Example 126)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1cnn(c1)C1COC1)c1ccc(O)cc1
Show InChI InChI=1S/C40H41ClN6O5/c1-26-36(40(50)47(30-8-10-34(48)11-9-30)32-20-42-46(23-32)33-24-52-25-33)19-38(43(26)2)37-18-29(41)7-12-35(37)39(49)45-21-28-6-4-3-5-27(28)17-31(45)22-44-13-15-51-16-14-44/h3-12,18-20,23,31,33,48H,13-17,21-22,24-25H2,1-2H3/t31-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.20n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
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