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Compile Data Set for Download or QSAR

Found 74 hits with Last Name = 'floridi' and Initial = 'm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50122243
PNG
(4-Chloro-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC3)C(=O)c3ccco3)c(Cl)c2=O)CC1
Show InChI InChI=1S/C33H45ClN6O4/c1-26(2)44-29-12-7-6-11-27(29)37-18-16-36(17-19-37)14-8-4-3-5-9-15-40-33(42)31(34)28(25-35-40)38-20-22-39(23-21-38)32(41)30-13-10-24-43-30/h6-7,10-13,24-26H,3-5,8-9,14-23H2,1-2H3
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0.0520n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50122242
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OC)c(=O)c1Cl
Show InChI InChI=1S/C36H51ClN6O4/c1-3-46-33-15-9-10-16-34(33)47-28-27-40-21-25-42(26-22-40)31-29-38-43(36(44)35(31)37)18-12-6-4-5-11-17-39-19-23-41(24-20-39)30-13-7-8-14-32(30)45-2/h7-10,13-16,29H,3-6,11-12,17-28H2,1-2H3
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0.160n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor receptor in rat cerebral cortex using [3H]-8-OH-DPAT


Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50122238
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OCC)c(=O)c1Cl
Show InChI InChI=1S/C37H53ClN6O4/c1-3-46-33-15-9-8-14-31(33)42-24-20-40(21-25-42)18-12-6-5-7-13-19-44-37(45)36(38)32(30-39-44)43-26-22-41(23-27-43)28-29-48-35-17-11-10-16-34(35)47-4-2/h8-11,14-17,30H,3-7,12-13,18-29H2,1-2H3
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0.220n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor receptor in rat cerebral cortex using [3H]-8-OH-DPAT


Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM29568
PNG
(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
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0.240n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM29568
PNG
(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
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0.240n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 12: 437-40 (2002)


BindingDB Entry DOI: 10.7270/Q2XW4N1S
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50122239
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OC(C)C)c(=O)c1Cl
Show InChI InChI=1S/C38H55ClN6O4/c1-4-47-35-16-10-11-17-36(35)48-29-28-42-22-26-44(27-23-42)33-30-40-45(38(46)37(33)39)19-13-7-5-6-12-18-41-20-24-43(25-21-41)32-14-8-9-15-34(32)49-31(2)3/h8-11,14-17,30-31H,4-7,12-13,18-29H2,1-3H3
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0.260n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131709
PNG
(5-Chloro-2-{7-[4-(2-ethoxy-phenyl)-piperazin-1-yl]...)
Show SMILES CCOc1ccccc1N1CCN(CCCCCCCn2ncc(Cl)c(N3CCN(CC3)C(=O)c3ccco3)c2=O)CC1
Show InChI InChI=1S/C32H43ClN6O4/c1-2-42-28-12-7-6-11-27(28)36-18-16-35(17-19-36)14-8-4-3-5-9-15-39-32(41)30(26(33)25-34-39)37-20-22-38(23-21-37)31(40)29-13-10-24-43-29/h6-7,10-13,24-25H,2-5,8-9,14-23H2,1H3
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0.350n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131714
PNG
(5-Chloro-4-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylme...)
Show SMILES COc1ccccc1N1CCN(CCCCCCCn2ncc(Cl)c(N3CCN(CC4COc5ccccc5O4)CC3)c2=O)CC1
Show InChI InChI=1S/C35H47ClN6O4/c1-44-31-12-6-5-11-30(31)40-21-17-38(18-22-40)15-9-3-2-4-10-16-42-35(43)34(29(36)25-37-42)41-23-19-39(20-24-41)26-28-27-45-32-13-7-8-14-33(32)46-28/h5-8,11-14,25,28H,2-4,9-10,15-24,26-27H2,1H3
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0.400n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131707
PNG
(5-Chloro-4-[4-(furan-2-carbonyl)-piperazin-1-yl]-2...)
Show SMILES COc1ccccc1N1CCN(CCCCCCCn2ncc(Cl)c(N3CCN(CC3)C(=O)c3ccco3)c2=O)CC1
Show InChI InChI=1S/C31H41ClN6O4/c1-41-27-11-6-5-10-26(27)35-17-15-34(16-18-35)13-7-3-2-4-8-14-38-31(40)29(25(32)24-33-38)36-19-21-37(22-20-36)30(39)28-12-9-23-42-28/h5-6,9-12,23-24H,2-4,7-8,13-22H2,1H3
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0.420n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50122238
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OCC)c(=O)c1Cl
Show InChI InChI=1S/C37H53ClN6O4/c1-3-46-33-15-9-8-14-31(33)42-24-20-40(21-25-42)18-12-6-5-7-13-19-44-37(45)36(38)32(30-39-44)43-26-22-41(23-27-43)28-29-48-35-17-11-10-16-34(35)47-4-2/h8-11,14-17,30H,3-7,12-13,18-29H2,1-2H3
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0.430n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50222045
PNG
(CHEMBL45726)
Show SMILES CCOc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC3)C(=O)c3ccco3)c(Cl)c2=O)CC1
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0.5n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50122242
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OC)c(=O)c1Cl
Show InChI InChI=1S/C36H51ClN6O4/c1-3-46-33-15-9-10-16-34(33)47-28-27-40-21-25-42(26-22-40)31-29-38-43(36(44)35(31)37)18-12-6-4-5-11-17-39-19-23-41(24-20-39)30-13-7-8-14-32(30)45-2/h7-10,13-16,29H,3-6,11-12,17-28H2,1-2H3
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0.550n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50122243
PNG
(4-Chloro-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC3)C(=O)c3ccco3)c(Cl)c2=O)CC1
Show InChI InChI=1S/C33H45ClN6O4/c1-26(2)44-29-12-7-6-11-27(29)37-18-16-36(17-19-37)14-8-4-3-5-9-15-40-33(42)31(34)28(25-35-40)38-20-22-39(23-21-38)32(41)30-13-10-24-43-30/h6-7,10-13,24-26H,3-5,8-9,14-23H2,1-2H3
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0.560n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.


Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50222044
PNG
(CHEMBL300092)
Show SMILES CCOc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CCOc4ccccc4OC)CC3)c(Cl)c2=O)CC1
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0.580n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50122243
PNG
(4-Chloro-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC3)C(=O)c3ccco3)c(Cl)c2=O)CC1
Show InChI InChI=1S/C33H45ClN6O4/c1-26(2)44-29-12-7-6-11-27(29)37-18-16-36(17-19-37)14-8-4-3-5-9-15-40-33(42)31(34)28(25-35-40)38-20-22-39(23-21-38)32(41)30-13-10-24-43-30/h6-7,10-13,24-26H,3-5,8-9,14-23H2,1-2H3
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0.800n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor receptor in rat cerebral cortex using [3H]-8-OH-DPAT


Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50122242
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OC)c(=O)c1Cl
Show InChI InChI=1S/C36H51ClN6O4/c1-3-46-33-15-9-10-16-34(33)47-28-27-40-21-25-42(26-22-40)31-29-38-43(36(44)35(31)37)18-12-6-4-5-11-17-39-19-23-41(24-20-39)30-13-7-8-14-32(30)45-2/h7-10,13-16,29H,3-6,11-12,17-28H2,1-2H3
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0.820n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50122239
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OC(C)C)c(=O)c1Cl
Show InChI InChI=1S/C38H55ClN6O4/c1-4-47-35-16-10-11-17-36(35)48-29-28-42-22-26-44(27-23-42)33-30-40-45(38(46)37(33)39)19-13-7-5-6-12-18-41-20-24-43(25-21-41)32-14-8-9-15-34(32)49-31(2)3/h8-11,14-17,30-31H,4-7,12-13,18-29H2,1-3H3
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0.820n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor in rat cerebral cortex


Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50122243
PNG
(4-Chloro-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC3)C(=O)c3ccco3)c(Cl)c2=O)CC1
Show InChI InChI=1S/C33H45ClN6O4/c1-26(2)44-29-12-7-6-11-27(29)37-18-16-36(17-19-37)14-8-4-3-5-9-15-40-33(42)31(34)28(25-35-40)38-20-22-39(23-21-38)32(41)30-13-10-24-43-30/h6-7,10-13,24-26H,3-5,8-9,14-23H2,1-2H3
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0.900n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131710
PNG
(5-Chloro-4-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylme...)
Show SMILES CCOc1ccccc1N1CCN(CCCCCCCn2ncc(Cl)c(N3CCN(CC4COc5ccccc5O4)CC3)c2=O)CC1
Show InChI InChI=1S/C36H49ClN6O4/c1-2-45-32-13-7-6-12-31(32)41-22-18-39(19-23-41)16-10-4-3-5-11-17-43-36(44)35(30(37)26-38-43)42-24-20-40(21-25-42)27-29-28-46-33-14-8-9-15-34(33)47-29/h6-9,12-15,26,29H,2-5,10-11,16-25,27-28H2,1H3
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1.02n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50109283
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(4-(4-(2-methoxyphe...)
Show SMILES COc1ccccc1N1CCN(CCCCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C26H30N6O2/c1-34-24-11-5-4-10-23(24)30-18-16-29(17-19-30)14-6-7-15-32-26(33)13-12-25(28-32)31-20-27-21-8-2-3-9-22(21)31/h2-5,8-13,20H,6-7,14-19H2,1H3
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1.10n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 12: 437-40 (2002)


BindingDB Entry DOI: 10.7270/Q2XW4N1S
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131712
PNG
(5-Chloro-4-[4-(furan-2-carbonyl)-piperazin-1-yl]-2...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCCCCCn2ncc(Cl)c(N3CCN(CC3)C(=O)c3ccco3)c2=O)CC1
Show InChI InChI=1S/C33H45ClN6O4/c1-26(2)44-29-12-7-6-11-28(29)37-18-16-36(17-19-37)14-8-4-3-5-9-15-40-33(42)31(27(34)25-35-40)38-20-22-39(23-21-38)32(41)30-13-10-24-43-30/h6-7,10-13,24-26H,3-5,8-9,14-23H2,1-2H3
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1.16n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50122238
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OCC)c(=O)c1Cl
Show InChI InChI=1S/C37H53ClN6O4/c1-3-46-33-15-9-8-14-31(33)42-24-20-40(21-25-42)18-12-6-5-7-13-19-44-37(45)36(38)32(30-39-44)43-26-22-41(23-27-43)28-29-48-35-17-11-10-16-34(35)47-4-2/h8-11,14-17,30H,3-7,12-13,18-29H2,1-2H3
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1.32n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50222012
PNG
(CHEMBL49152)
Show SMILES COc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OC)c(=O)c1Cl
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1.40n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131711
PNG
(5-Chloro-4-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylme...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCCCCCn2ncc(Cl)c(N3CCN(CC4COc5ccccc5O4)CC3)c2=O)CC1
Show InChI InChI=1S/C37H51ClN6O4/c1-29(2)47-33-13-7-6-12-32(33)42-22-18-40(19-23-42)16-10-4-3-5-11-17-44-37(45)36(31(38)26-39-44)43-24-20-41(21-25-43)27-30-28-46-34-14-8-9-15-35(34)48-30/h6-9,12-15,26,29-30H,3-5,10-11,16-25,27-28H2,1-2H3
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1.52n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50122242
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OC)c(=O)c1Cl
Show InChI InChI=1S/C36H51ClN6O4/c1-3-46-33-15-9-10-16-34(33)47-28-27-40-21-25-42(26-22-40)31-29-38-43(36(44)35(31)37)18-12-6-4-5-11-17-39-19-23-41(24-20-39)30-13-7-8-14-32(30)45-2/h7-10,13-16,29H,3-6,11-12,17-28H2,1-2H3
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1.60n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50222046
PNG
(CHEMBL46172)
Show SMILES COc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC3)C(=O)c3ccco3)c(Cl)c2=O)CC1
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1.90n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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2n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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2n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor in rat cerebral cortex


Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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2n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50122238
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OCC)c(=O)c1Cl
Show InChI InChI=1S/C37H53ClN6O4/c1-3-46-33-15-9-8-14-31(33)42-24-20-40(21-25-42)18-12-6-5-7-13-19-44-37(45)36(38)32(30-39-44)43-26-22-41(23-27-43)28-29-48-35-17-11-10-16-34(35)47-4-2/h8-11,14-17,30H,3-7,12-13,18-29H2,1-2H3
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2n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131706
PNG
(4-Chloro-5-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylme...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC4COc5ccccc5O4)CC3)c(Cl)c2=O)CC1
Show InChI InChI=1S/C37H51ClN6O4/c1-29(2)47-33-13-7-6-12-31(33)42-22-18-40(19-23-42)16-10-4-3-5-11-17-44-37(45)36(38)32(26-39-44)43-24-20-41(21-25-43)27-30-28-46-34-14-8-9-15-35(34)48-30/h6-9,12-15,26,29-30H,3-5,10-11,16-25,27-28H2,1-2H3
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2.47n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50122239
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OC(C)C)c(=O)c1Cl
Show InChI InChI=1S/C38H55ClN6O4/c1-4-47-35-16-10-11-17-36(35)48-29-28-42-22-26-44(27-23-42)33-30-40-45(38(46)37(33)39)19-13-7-5-6-12-18-41-20-24-43(25-21-41)32-14-8-9-15-34(32)49-31(2)3/h8-11,14-17,30-31H,4-7,12-13,18-29H2,1-3H3
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2.54n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50122239
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OC(C)C)c(=O)c1Cl
Show InChI InChI=1S/C38H55ClN6O4/c1-4-47-35-16-10-11-17-36(35)48-29-28-42-22-26-44(27-23-42)33-30-40-45(38(46)37(33)39)19-13-7-5-6-12-18-41-20-24-43(25-21-41)32-14-8-9-15-34(32)49-31(2)3/h8-11,14-17,30-31H,4-7,12-13,18-29H2,1-3H3
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3.20n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50026636
PNG
(17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic...)
Show SMILES COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r|
Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15+,17+,18+,19+/m1/s1
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4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50222045
PNG
(CHEMBL45726)
Show SMILES CCOc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC3)C(=O)c3ccco3)c(Cl)c2=O)CC1
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4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50026636
PNG
(17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic...)
Show SMILES COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r|
Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15+,17+,18+,19+/m1/s1
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4n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 12: 437-40 (2002)


BindingDB Entry DOI: 10.7270/Q2XW4N1S
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50222012
PNG
(CHEMBL49152)
Show SMILES COc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OC)c(=O)c1Cl
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4.60n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50109287
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(3-(4-(2-methoxyphe...)
Show SMILES COc1ccccc1N1CCN(CCCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C25H28N6O2/c1-33-23-10-5-4-9-22(23)29-17-15-28(16-18-29)13-6-14-31-25(32)12-11-24(27-31)30-19-26-20-7-2-3-8-21(20)30/h2-5,7-12,19H,6,13-18H2,1H3
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6.5n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 12: 437-40 (2002)


BindingDB Entry DOI: 10.7270/Q2XW4N1S
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50222044
PNG
(CHEMBL300092)
Show SMILES CCOc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CCOc4ccccc4OC)CC3)c(Cl)c2=O)CC1
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8.20n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 13: 171-3 (2002)


BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131708
PNG
(4-Chloro-5-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylme...)
Show SMILES COc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC4COc5ccccc5O4)CC3)c(Cl)c2=O)CC1
Show InChI InChI=1S/C35H47ClN6O4/c1-44-31-12-6-5-11-29(31)40-21-17-38(18-22-40)15-9-3-2-4-10-16-42-35(43)34(36)30(25-37-42)41-23-19-39(20-24-41)26-28-27-45-32-13-7-8-14-33(32)46-28/h5-8,11-14,25,28H,2-4,9-10,15-24,26-27H2,1H3
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11.1n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50109284
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(3-(4-(2-chlorophen...)
Show SMILES Clc1ccccc1N1CCN(CCCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C24H25ClN6O/c25-19-6-1-3-8-21(19)29-16-14-28(15-17-29)12-5-13-31-24(32)11-10-23(27-31)30-18-26-20-7-2-4-9-22(20)30/h1-4,6-11,18H,5,12-17H2
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15n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 12: 437-40 (2002)


BindingDB Entry DOI: 10.7270/Q2XW4N1S
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50109283
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(4-(4-(2-methoxyphe...)
Show SMILES COc1ccccc1N1CCN(CCCCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C26H30N6O2/c1-34-24-11-5-4-10-23(24)30-18-16-29(17-19-30)14-6-7-15-32-26(33)13-12-25(28-32)31-20-27-21-8-2-3-9-22(21)31/h2-5,8-13,20H,6-7,14-19H2,1H3
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16n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 12: 437-40 (2002)


BindingDB Entry DOI: 10.7270/Q2XW4N1S
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50109284
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(3-(4-(2-chlorophen...)
Show SMILES Clc1ccccc1N1CCN(CCCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C24H25ClN6O/c25-19-6-1-3-8-21(19)29-16-14-28(15-17-29)12-5-13-31-24(32)11-10-23(27-31)30-18-26-20-7-2-4-9-22(20)30/h1-4,6-11,18H,5,12-17H2
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45n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 12: 437-40 (2002)


BindingDB Entry DOI: 10.7270/Q2XW4N1S
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50109285
PNG
(2-(3-(4-(2-chlorophenyl)piperazin-1-yl)propyl)-6-(...)
Show SMILES Clc1ccccc1N1CCN(CCCn2nc(ccc2=O)-n2ccnc2)CC1
Show InChI InChI=1S/C20H23ClN6O/c21-17-4-1-2-5-18(17)25-14-12-24(13-15-25)9-3-10-27-20(28)7-6-19(23-27)26-11-8-22-16-26/h1-2,4-8,11,16H,3,9-10,12-15H2
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48n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 12: 437-40 (2002)


BindingDB Entry DOI: 10.7270/Q2XW4N1S
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131713
PNG
(4-Chloro-5-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylme...)
Show SMILES CCOc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC4COc5ccccc5O4)CC3)c(Cl)c2=O)CC1
Show InChI InChI=1S/C36H49ClN6O4/c1-2-45-32-13-7-6-12-30(32)41-22-18-39(19-23-41)16-10-4-3-5-11-17-43-36(44)35(37)31(26-38-43)42-24-20-40(21-25-42)27-29-28-46-33-14-8-9-15-34(33)47-29/h6-9,12-15,26,29H,2-5,10-11,16-25,27-28H2,1H3
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49.8n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117131
PNG
(6-(1H-imidazol-1-yl)-2-(7-(4-(2-methoxyphenyl)pipe...)
Show SMILES COc1ccccc1N1CCN(CCCCCCCn2nc(ccc2=O)-n2ccnc2)CC1
Show InChI InChI=1S/C25H34N6O2/c1-33-23-10-6-5-9-22(23)29-19-17-28(18-20-29)14-7-3-2-4-8-15-31-25(32)12-11-24(27-31)30-16-13-26-21-30/h5-6,9-13,16,21H,2-4,7-8,14-15,17-20H2,1H3
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98.7n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117123
PNG
(6-(1H-indol-1-yl)-2-(3-(4-(2-methoxyphenyl)piperaz...)
Show SMILES COc1ccccc1N1CCN(CCCn2nc(ccc2=O)-n2ccc3ccccc23)CC1
Show InChI InChI=1S/C26H29N5O2/c1-33-24-10-5-4-9-23(24)29-19-17-28(18-20-29)14-6-15-31-26(32)12-11-25(27-31)30-16-13-21-7-2-3-8-22(21)30/h2-5,7-13,16H,6,14-15,17-20H2,1H3
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103n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117127
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(6-(4-(2-methoxyphe...)
Show SMILES COc1ccccc1N1CCN(CCCCCCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C28H34N6O2/c1-36-26-13-7-6-12-25(26)32-20-18-31(19-21-32)16-8-2-3-9-17-34-28(35)15-14-27(30-34)33-22-29-23-10-4-5-11-24(23)33/h4-7,10-15,22H,2-3,8-9,16-21H2,1H3
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106n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50109286
PNG
(6-(1H-imidazol-1-yl)-2-(3-(4-(2-methoxyphenyl)pipe...)
Show SMILES COc1ccccc1N1CCN(CCCn2nc(ccc2=O)-n2ccnc2)CC1
Show InChI InChI=1S/C21H26N6O2/c1-29-19-6-3-2-5-18(19)25-15-13-24(14-16-25)10-4-11-27-21(28)8-7-20(23-27)26-12-9-22-17-26/h2-3,5-9,12,17H,4,10-11,13-16H2,1H3
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115n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL




Bioorg Med Chem Lett 12: 437-40 (2002)


BindingDB Entry DOI: 10.7270/Q2XW4N1S
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117116
PNG
(2-(7-(4-(2-chlorophenyl)piperazin-1-yl)heptyl)-6-(...)
Show SMILES Clc1ccccc1N1CCN(CCCCCCCn2nc(ccc2=O)-n2ccnc2)CC1
Show InChI InChI=1S/C24H31ClN6O/c25-21-8-4-5-9-22(21)29-18-16-28(17-19-29)13-6-2-1-3-7-14-31-24(32)11-10-23(27-31)30-15-12-26-20-30/h4-5,8-12,15,20H,1-3,6-7,13-14,16-19H2
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123n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
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