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Compile Data Set for Download or QSAR

Found 57 hits with Last Name = 'friese-hamim' and Initial = 'm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065485
PNG
(CHEMBL3402760)
Show SMILES CN(C)CCCOc1cnc(nc1)-c1cccc(Cn2nc(ccc2=O)-c2cccc(c2)C#N)c1
Show InChI InChI=1S/C27H26N6O2/c1-32(2)12-5-13-35-24-17-29-27(30-18-24)23-9-4-7-21(15-23)19-33-26(34)11-10-25(31-33)22-8-3-6-20(14-22)16-28/h3-4,6-11,14-15,17-18H,5,12-13,19H2,1-2H3
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065458
PNG
(CHEMBL3402761)
Show SMILES O=c1ccc(nn1Cc1cccc(c1)-c1ncc(OCCN2CCOCC2)cn1)-c1cccc(c1)C#N
Show InChI InChI=1S/C28H26N6O3/c29-17-21-3-1-5-23(15-21)26-7-8-27(35)34(32-26)20-22-4-2-6-24(16-22)28-30-18-25(19-31-28)37-14-11-33-9-12-36-13-10-33/h1-8,15-16,18-19H,9-14,20H2
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065457
PNG
(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Show SMILES CN1CCC(COc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-c3cccc(c3)C#N)c2)CC1
Show InChI InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065490
PNG
(CHEMBL3402754)
Show SMILES Cc1cnc(nc1)-c1cccc(Cn2nc(ccc2=O)-c2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C22H16F2N4O/c1-14-11-25-22(26-12-14)16-4-2-3-15(7-16)13-28-21(29)6-5-20(27-28)17-8-18(23)10-19(24)9-17/h2-12H,13H2,1H3
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase in human A549 cells assessed as inhibition of phosphorylation after 45 mins by electrochemiluminescence assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065489
PNG
(CHEMBL3402756)
Show SMILES CN(C)CCCOc1cnc(nc1)-c1cccc(Cn2nc(ccc2=O)-c2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C26H25F2N5O2/c1-32(2)9-4-10-35-23-15-29-26(30-16-23)19-6-3-5-18(11-19)17-33-25(34)8-7-24(31-33)20-12-21(27)14-22(28)13-20/h3,5-8,11-16H,4,9-10,17H2,1-2H3
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor (RON)


(Homo sapiens (Human))
BDBM213708
PNG
(US9283225, A1)
Show SMILES Fc1cc(NC(=O)c2cnn(c2C(F)(F)F)-c2ccccc2)ccc1Oc1ccnc2NC(=O)NCc12
Show InChI InChI=1S/C24H16F4N6O3/c25-17-10-13(6-7-19(17)37-18-8-9-29-21-15(18)11-30-23(36)33-21)32-22(35)16-12-31-34(20(16)24(26,27)28)14-4-2-1-3-5-14/h1-10,12H,11H2,(H,32,35)(H2,29,30,33,36)
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US Patent
n/an/a 4.30n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out as 384-well FlashPlate assay. As test plates 384-well streptavidine coated FlashPlate microtitre plates from Perkin ...


US Patent US9283225 (2016)


BindingDB Entry DOI: 10.7270/Q2959GC8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065486
PNG
(CHEMBL3402759)
Show SMILES COc1cccc(c1)-c1ccc(=O)n(Cc2cccc(c2)-c2ncc(OCCCN(C)C)cn2)n1
Show InChI InChI=1S/C27H29N5O3/c1-31(2)13-6-14-35-24-17-28-27(29-18-24)22-9-4-7-20(15-22)19-32-26(33)12-11-25(30-32)21-8-5-10-23(16-21)34-3/h4-5,7-12,15-18H,6,13-14,19H2,1-3H3
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065488
PNG
(CHEMBL3402757)
Show SMILES CN(C)CCCOc1cnc(nc1)-c1cccc(Cn2nc(ccc2=O)-c2cccc(F)c2)c1
Show InChI InChI=1S/C26H26FN5O2/c1-31(2)12-5-13-34-23-16-28-26(29-17-23)21-8-3-6-19(14-21)18-32-25(33)11-10-24(30-32)20-7-4-9-22(27)15-20/h3-4,6-11,14-17H,5,12-13,18H2,1-2H3
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor (RON)


(Homo sapiens (Human))
BDBM213709
PNG
(US9283225, A3)
Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)Nc1ccc(Oc2ccnc3NC(=O)NCc23)c(F)c1
Show InChI InChI=1S/C24H19FN6O3/c1-14-17(13-28-31(14)16-5-3-2-4-6-16)23(32)29-15-7-8-21(19(25)11-15)34-20-9-10-26-22-18(20)12-27-24(33)30-22/h2-11,13H,12H2,1H3,(H,29,32)(H2,26,27,30,33)
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n/an/a 10n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out as 384-well FlashPlate assay. As test plates 384-well streptavidine coated FlashPlate microtitre plates from Perkin ...


US Patent US9283225 (2016)


BindingDB Entry DOI: 10.7270/Q2959GC8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065487
PNG
(CHEMBL3402758)
Show SMILES CN(C)CCCOc1cnc(nc1)-c1cccc(Cn2nc(ccc2=O)-c2cccnc2)c1
Show InChI InChI=1S/C25H26N6O2/c1-30(2)12-5-13-33-22-16-27-25(28-17-22)20-7-3-6-19(14-20)18-31-24(32)10-9-23(29-31)21-8-4-11-26-15-21/h3-4,6-11,14-17H,5,12-13,18H2,1-2H3
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065493
PNG
(CHEMBL3402765)
Show SMILES Fc1cc(F)cc(c1)-c1ccc(=O)n(Cc2cccc(NC(=O)OCCCN3CCOCC3)c2)n1
Show InChI InChI=1S/C25H26F2N4O4/c26-20-14-19(15-21(27)16-20)23-5-6-24(32)31(29-23)17-18-3-1-4-22(13-18)28-25(33)35-10-2-7-30-8-11-34-12-9-30/h1,3-6,13-16H,2,7-12,17H2,(H,28,33)
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065457
PNG
(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Show SMILES CN1CCC(COc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-c3cccc(c3)C#N)c2)CC1
Show InChI InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3
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n/an/a 12n/an/an/an/an/an/a



Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase in human A549 cells assessed as inhibition of phosphorylation after 45 mins by electrochemiluminescence assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065489
PNG
(CHEMBL3402756)
Show SMILES CN(C)CCCOc1cnc(nc1)-c1cccc(Cn2nc(ccc2=O)-c2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C26H25F2N5O2/c1-32(2)9-4-10-35-23-15-29-26(30-16-23)19-6-3-5-18(11-19)17-33-25(34)8-7-24(31-33)20-12-21(27)14-22(28)13-20/h3,5-8,11-16H,4,9-10,17H2,1-2H3
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase in human A549 cells assessed as inhibition of phosphorylation after 45 mins by electrochemiluminescence assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065485
PNG
(CHEMBL3402760)
Show SMILES CN(C)CCCOc1cnc(nc1)-c1cccc(Cn2nc(ccc2=O)-c2cccc(c2)C#N)c1
Show InChI InChI=1S/C27H26N6O2/c1-32(2)12-5-13-35-24-17-29-27(30-18-24)23-9-4-7-21(15-23)19-33-26(34)11-10-25(31-33)22-8-3-6-20(14-22)16-28/h3-4,6-11,14-15,17-18H,5,12-13,19H2,1-2H3
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase in human A549 cells assessed as inhibition of phosphorylation after 45 mins by electrochemiluminescence assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065492
PNG
(CHEMBL3402742)
Show SMILES CN(C)CCCOC(=O)Nc1cccc(CN2N=C(CSC2=O)c2cc(F)cc(F)c2)c1 |c:17|
Show InChI InChI=1S/C22H24F2N4O3S/c1-27(2)7-4-8-31-21(29)25-19-6-3-5-15(9-19)13-28-22(30)32-14-20(26-28)16-10-17(23)12-18(24)11-16/h3,5-6,9-12H,4,7-8,13-14H2,1-2H3,(H,25,29)
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065487
PNG
(CHEMBL3402758)
Show SMILES CN(C)CCCOc1cnc(nc1)-c1cccc(Cn2nc(ccc2=O)-c2cccnc2)c1
Show InChI InChI=1S/C25H26N6O2/c1-30(2)12-5-13-33-22-16-27-25(28-17-22)20-7-3-6-19(14-20)18-31-24(32)10-9-23(29-31)21-8-4-11-26-15-21/h3-4,6-11,14-17H,5,12-13,18H2,1-2H3
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n/an/a 28n/an/an/an/an/an/a



Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase in human A549 cells assessed as inhibition of phosphorylation after 45 mins by electrochemiluminescence assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065458
PNG
(CHEMBL3402761)
Show SMILES O=c1ccc(nn1Cc1cccc(c1)-c1ncc(OCCN2CCOCC2)cn1)-c1cccc(c1)C#N
Show InChI InChI=1S/C28H26N6O3/c29-17-21-3-1-5-23(15-21)26-7-8-27(35)34(32-26)20-22-4-2-6-24(16-22)28-30-18-25(19-31-28)37-14-11-33-9-12-36-13-10-33/h1-8,15-16,18-19H,9-14,20H2
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n/an/a 34n/an/an/an/an/an/a



Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase in human A549 cells assessed as inhibition of phosphorylation after 45 mins by electrochemiluminescence assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens (Human))
BDBM50234032
PNG
(CHEMBL4060668)
Show SMILES C(Oc1cncc2ccccc12)[C@H]1CCCN1c1ccnc2ncnn12 |r|
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n/an/a 38n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL




Bioorg Med Chem Lett 27: 551-556 (2017)


BindingDB Entry DOI: 10.7270/Q2V98BB4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065490
PNG
(CHEMBL3402754)
Show SMILES Cc1cnc(nc1)-c1cccc(Cn2nc(ccc2=O)-c2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C22H16F2N4O/c1-14-11-25-22(26-12-14)16-4-2-3-15(7-16)13-28-21(29)6-5-20(27-28)17-8-18(23)10-19(24)9-17/h2-12H,13H2,1H3
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065491
PNG
(CHEMBL3402743)
Show SMILES CN(C)CCCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-c2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C23H24F2N4O3/c1-28(2)9-4-10-32-23(31)26-20-6-3-5-16(11-20)15-29-22(30)8-7-21(27-29)17-12-18(24)14-19(25)13-17/h3,5-8,11-14H,4,9-10,15H2,1-2H3,(H,26,31)
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n/an/a 42n/an/an/an/an/an/a



Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens (Human))
BDBM50065456
PNG
(CHEMBL3402741)
Show SMILES CCN(CC)CCCOC(=O)Nc1cccc(CN2N=C(CSC2=O)c2ccc(OC)c(OC)c2)c1 |c:19|
Show InChI InChI=1S/C26H34N4O5S/c1-5-29(6-2)13-8-14-35-25(31)27-21-10-7-9-19(15-21)17-30-26(32)36-18-22(28-30)20-11-12-23(33-3)24(16-20)34-4/h7,9-12,15-16H,5-6,8,13-14,17-18H2,1-4H3,(H,27,31)
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n/an/a 63n/an/an/an/an/an/a



Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of PDE4 (unknown origin)


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065492
PNG
(CHEMBL3402742)
Show SMILES CN(C)CCCOC(=O)Nc1cccc(CN2N=C(CSC2=O)c2cc(F)cc(F)c2)c1 |c:17|
Show InChI InChI=1S/C22H24F2N4O3S/c1-27(2)7-4-8-31-21(29)25-19-6-3-5-15(9-19)13-28-22(30)32-14-20(26-28)16-10-17(23)12-18(24)11-16/h3,5-6,9-12H,4,7-8,13-14H2,1-2H3,(H,25,29)
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n/an/a 78n/an/an/an/an/an/a



Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase in human A549 cells assessed as inhibition of phosphorylation after 45 mins by electrochemiluminescence assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065494
PNG
(CHEMBL3402764)
Show SMILES CN(C)CCCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-c2ccc(F)cc2)c1
Show InChI InChI=1S/C23H25FN4O3/c1-27(2)13-4-14-31-23(30)25-20-6-3-5-17(15-20)16-28-22(29)12-11-21(26-28)18-7-9-19(24)10-8-18/h3,5-12,15H,4,13-14,16H2,1-2H3,(H,25,30)
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n/an/a 90n/an/an/an/an/an/a



Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065495
PNG
(CHEMBL3402763)
Show SMILES CCN(CC)CCCOC(=O)Nc1cccc(CN2N=C(CSC2=O)c2ccc(Cl)cc2)c1 |c:19|
Show InChI InChI=1S/C24H29ClN4O3S/c1-3-28(4-2)13-6-14-32-23(30)26-21-8-5-7-18(15-21)16-29-24(31)33-17-22(27-29)19-9-11-20(25)12-10-19/h5,7-12,15H,3-4,6,13-14,16-17H2,1-2H3,(H,26,30)
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens (Human))
BDBM50234031
PNG
(CHEMBL4082542)
Show SMILES C(Oc1cccc2ccccc12)[C@H]1CCCN1c1ccnc2ncnn12 |r|
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n/an/a 110n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL




Bioorg Med Chem Lett 27: 551-556 (2017)


BindingDB Entry DOI: 10.7270/Q2V98BB4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065488
PNG
(CHEMBL3402757)
Show SMILES CN(C)CCCOc1cnc(nc1)-c1cccc(Cn2nc(ccc2=O)-c2cccc(F)c2)c1
Show InChI InChI=1S/C26H26FN5O2/c1-31(2)12-5-13-34-23-16-28-26(29-17-23)21-8-3-6-19(14-21)18-32-25(33)11-10-24(30-32)20-7-4-9-22(27)15-20/h3-4,6-11,14-17H,5,12-13,18H2,1-2H3
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase in human A549 cells assessed as inhibition of phosphorylation after 45 mins by electrochemiluminescence assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065491
PNG
(CHEMBL3402743)
Show SMILES CN(C)CCCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-c2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C23H24F2N4O3/c1-28(2)9-4-10-32-23(31)26-20-6-3-5-16(11-20)15-29-22(30)8-7-21(27-29)17-12-18(24)14-19(25)13-17/h3,5-8,11-14H,4,9-10,15H2,1-2H3,(H,26,31)
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n/an/a 150n/an/an/an/an/an/a



Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase in human A549 cells assessed as inhibition of phosphorylation after 45 mins by electrochemiluminescence assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065497
PNG
(CHEMBL3402753)
Show SMILES Cc1ccc(nc1)-c1cccc(Cn2nc(ccc2=O)-c2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C23H17F2N3O/c1-15-5-6-21(26-13-15)17-4-2-3-16(9-17)14-28-23(29)8-7-22(27-28)18-10-19(24)12-20(25)11-18/h2-13H,14H2,1H3
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065505
PNG
(CHEMBL3402745)
Show SMILES CCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-c2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C20H17F2N3O3/c1-2-28-20(27)23-17-5-3-4-13(8-17)12-25-19(26)7-6-18(24-25)14-9-15(21)11-16(22)10-14/h3-11H,2,12H2,1H3,(H,23,27)
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065486
PNG
(CHEMBL3402759)
Show SMILES COc1cccc(c1)-c1ccc(=O)n(Cc2cccc(c2)-c2ncc(OCCCN(C)C)cn2)n1
Show InChI InChI=1S/C27H29N5O3/c1-31(2)13-6-14-35-24-17-28-27(29-18-24)22-9-4-7-20(15-22)19-32-26(33)12-11-25(30-32)21-8-5-10-23(16-21)34-3/h4-5,7-12,15-18H,6,13-14,19H2,1-3H3
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase in human A549 cells assessed as inhibition of phosphorylation after 45 mins by electrochemiluminescence assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens (Human))
BDBM50234025
PNG
(CHEMBL4093791)
Show SMILES C(Oc1cccc2cnccc12)[C@H]1CCCN1c1ncnc2[nH]cnc12 |r|
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n/an/a 230n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL




Bioorg Med Chem Lett 27: 551-556 (2017)


BindingDB Entry DOI: 10.7270/Q2V98BB4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065506
PNG
(CHEMBL3402744)
Show SMILES COC(=O)Nc1cccc(Cn2nc(ccc2=O)-c2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C19H15F2N3O3/c1-27-19(26)22-16-4-2-3-12(7-16)11-24-18(25)6-5-17(23-24)13-8-14(20)10-15(21)9-13/h2-10H,11H2,1H3,(H,22,26)
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065456
PNG
(CHEMBL3402741)
Show SMILES CCN(CC)CCCOC(=O)Nc1cccc(CN2N=C(CSC2=O)c2ccc(OC)c(OC)c2)c1 |c:19|
Show InChI InChI=1S/C26H34N4O5S/c1-5-29(6-2)13-8-14-35-25(31)27-21-10-7-9-19(15-21)17-30-26(32)36-18-22(28-30)20-11-12-23(33-3)24(16-20)34-4/h7,9-12,15-16H,5-6,8,13-14,17-18H2,1-4H3,(H,27,31)
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n/an/a 400n/an/an/an/an/an/a



Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065500
PNG
(CHEMBL3402750)
Show SMILES Cc1cnc(s1)-c1cccc(Cn2nc(ccc2=O)-c2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C21H15F2N3OS/c1-13-11-24-21(28-13)15-4-2-3-14(7-15)12-26-20(27)6-5-19(25-26)16-8-17(22)10-18(23)9-16/h2-11H,12H2,1H3
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens (Human))
BDBM50234035
PNG
(CHEMBL4070008)
Show SMILES C(Oc1cccc2ccccc12)[C@H]1CCCN1c1ncnc2[nH]cnc12 |r|
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Merck KGaA

Curated by ChEMBL




Bioorg Med Chem Lett 27: 551-556 (2017)


BindingDB Entry DOI: 10.7270/Q2V98BB4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065501
PNG
(CHEMBL3402749)
Show SMILES Cc1cnc(o1)-c1cccc(Cn2nc(ccc2=O)-c2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C21H15F2N3O2/c1-13-11-24-21(28-13)15-4-2-3-14(7-15)12-26-20(27)6-5-19(25-26)16-8-17(22)10-18(23)9-16/h2-11H,12H2,1H3
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens (Human))
BDBM50234037
PNG
(CHEMBL4083510)
Show SMILES C(Oc1cccc2ccccc12)[C@H]1CCCN1c1ccnc2nccn12 |r|
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Merck KGaA

Curated by ChEMBL




Bioorg Med Chem Lett 27: 551-556 (2017)


BindingDB Entry DOI: 10.7270/Q2V98BB4
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens (Human))
BDBM50234024
PNG
(CHEMBL4097198)
Show SMILES Cc1ccccc1OC[C@H]1CCCN1c1ncnc2[nH]cnc12 |r|
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Merck KGaA

Curated by ChEMBL




Bioorg Med Chem Lett 27: 551-556 (2017)


BindingDB Entry DOI: 10.7270/Q2V98BB4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065504
PNG
(CHEMBL3402746)
Show SMILES Cc1nc(no1)-c1cccc(Cn2nc(ccc2=O)-c2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C20H14F2N4O2/c1-12-23-20(25-28-12)14-4-2-3-13(7-14)11-26-19(27)6-5-18(24-26)15-8-16(21)10-17(22)9-15/h2-10H,11H2,1H3
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Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens (Human))
BDBM50234033
PNG
(CHEMBL4078213)
Show SMILES Clc1ccccc1OC[C@H]1CCCN1c1ncnc2[nH]cnc12 |r|
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n/an/a 1.00E+3n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL




Bioorg Med Chem Lett 27: 551-556 (2017)


BindingDB Entry DOI: 10.7270/Q2V98BB4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065456
PNG
(CHEMBL3402741)
Show SMILES CCN(CC)CCCOC(=O)Nc1cccc(CN2N=C(CSC2=O)c2ccc(OC)c(OC)c2)c1 |c:19|
Show InChI InChI=1S/C26H34N4O5S/c1-5-29(6-2)13-8-14-35-25(31)27-21-10-7-9-19(15-21)17-30-26(32)36-18-22(28-30)20-11-12-23(33-3)24(16-20)34-4/h7,9-12,15-16H,5-6,8,13-14,17-18H2,1-4H3,(H,27,31)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase in human A549 cells assessed as inhibition of phosphorylation after 45 mins by electrochemiluminescence assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Microtubule-associated protein 2


(Homo sapiens (Human))
BDBM50234022
PNG
(CHEMBL4066295)
Show SMILES N#Cc1ccc(OC[C@H]2CCCN2c2ncnc3[nH]cnc23)cc1 |r|
KEGG

UniProtKB/SwissProt

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n/an/a 1.30E+3n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL




Bioorg Med Chem Lett 27: 551-556 (2017)


BindingDB Entry DOI: 10.7270/Q2V98BB4
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens (Human))
BDBM50234020
PNG
(CHEMBL4101592)
Show SMILES Fc1cccc(OC[C@H]2CCCN2c2ncnc3[nH]cnc23)c1F |r|
KEGG

UniProtKB/SwissProt

DrugBank
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UniChem
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n/an/a 1.60E+3n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL




Bioorg Med Chem Lett 27: 551-556 (2017)


BindingDB Entry DOI: 10.7270/Q2V98BB4
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens (Human))
BDBM50234030
PNG
(CHEMBL4101510)
Show SMILES C(Oc1cccc2ccccc12)[C@H]1CCCN1c1ncnc2ncnn12 |r|
KEGG

UniProtKB/SwissProt

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n/an/a 1.80E+3n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL




Bioorg Med Chem Lett 27: 551-556 (2017)


BindingDB Entry DOI: 10.7270/Q2V98BB4
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens (Human))
BDBM50234021
PNG
(CHEMBL4074903)
Show SMILES Fc1cccc(OC[C@H]2CCCN2c2ncnc3[nH]cnc23)c1 |r|
KEGG

UniProtKB/SwissProt

DrugBank
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UniChem
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n/an/a 2.00E+3n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL




Bioorg Med Chem Lett 27: 551-556 (2017)


BindingDB Entry DOI: 10.7270/Q2V98BB4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065499
PNG
(CHEMBL3402751)
Show SMILES Cc1csc(n1)-c1cccc(Cn2nc(ccc2=O)-c2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C21H15F2N3OS/c1-13-12-28-21(24-13)15-4-2-3-14(7-15)11-26-20(27)6-5-19(25-26)16-8-17(22)10-18(23)9-16/h2-10,12H,11H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

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CHEMBL
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n/an/a 2.10E+3n/an/an/an/an/an/a



Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens (Human))
BDBM50234027
PNG
(CHEMBL4086033)
Show SMILES Clc1ccccc1OC[C@H]1CCCN1c1ccnc2[nH]cnc12 |r|
KEGG

UniProtKB/SwissProt

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n/an/a 2.20E+3n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL




Bioorg Med Chem Lett 27: 551-556 (2017)


BindingDB Entry DOI: 10.7270/Q2V98BB4
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens (Human))
BDBM50234028
PNG
(CHEMBL4063448)
Show SMILES Clc1ccccc1OC[C@H]1CCCN1c1ccnc2nsnc12 |r|
KEGG

UniProtKB/SwissProt

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n/an/a 2.80E+3n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL




Bioorg Med Chem Lett 27: 551-556 (2017)


BindingDB Entry DOI: 10.7270/Q2V98BB4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065503
PNG
(CHEMBL3402747)
Show SMILES Cc1noc(n1)-c1cccc(Cn2nc(ccc2=O)-c2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C20H14F2N4O2/c1-12-23-20(28-25-12)14-4-2-3-13(7-14)11-26-19(27)6-5-18(24-26)15-8-16(21)10-17(22)9-15/h2-10H,11H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
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UniChem

Patents

Article
PubMed
n/an/a 3.40E+3n/an/an/an/an/an/a



Merck Serono Research& Development

Curated by ChEMBL


Assay Description
Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay


Bioorg Med Chem Lett 25: 1597-602 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.002
BindingDB Entry DOI: 10.7270/Q2HX1FBT
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens (Human))
BDBM50234034
PNG
(CHEMBL4093860)
Show SMILES Fc1ccc(OC[C@H]2CCCN2c2ncnc3[nH]cnc23)cc1 |r|
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
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n/an/a 3.80E+3n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL




Bioorg Med Chem Lett 27: 551-556 (2017)


BindingDB Entry DOI: 10.7270/Q2V98BB4
More data for this
Ligand-Target Pair
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