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Compile Data Set for Download or QSAR

Found 186 hits with Last Name = 'fujisawa' and Initial = 'y'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50221787
PNG
(CHEMBL3216418)
Show SMILES Cl.Cl.Cc1cc(O)cc(C)c1CC(N)C(=O)NCCCc1nc(O)c(CCCNC(=O)C(N)Cc2c(C)cc(O)cc2C)nc1C
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0.0420n/an/an/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL


Assay Description
Compound was tested for Opioid receptor mu 1 agonism in isolated tissues from guinea pig ileum


J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50221778
PNG
(CHEMBL3216392)
Show SMILES Cl.Cl.Cc1cc(O)cc(C)c1CC(N)C(=O)NCCCCc1nc(O)c(CCCCNC(=O)C(N)Cc2c(C)cc(O)cc2C)nc1C
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0.114n/an/an/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL




J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50221781
PNG
(CHEMBL3215968)
Show SMILES Cl.Cl.Cc1cc(O)cc(C)c1CC(N)C(=O)NCCc1nc(O)c(CCNC(=O)C(N)Cc2c(C)cc(O)cc2C)nc1C
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0.115n/an/an/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL


Assay Description
Compound was tested for Opioid receptor mu 1 agonism in isolated tissues from guinea pig ileum


J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50221780
PNG
(CHEMBL3217089)
Show SMILES Cl.Cl.Cc1cc(O)cc(C)c1CC(N)C(=O)NCc1nc(O)c(CNC(=O)C(N)Cc2c(C)cc(O)cc2C)nc1C
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1.20n/an/an/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL




J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50221781
PNG
(CHEMBL3215968)
Show SMILES Cl.Cl.Cc1cc(O)cc(C)c1CC(N)C(=O)NCCc1nc(O)c(CCNC(=O)C(N)Cc2c(C)cc(O)cc2C)nc1C
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7.30n/an/an/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL




J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50221787
PNG
(CHEMBL3216418)
Show SMILES Cl.Cl.Cc1cc(O)cc(C)c1CC(N)C(=O)NCCCc1nc(O)c(CCCNC(=O)C(N)Cc2c(C)cc(O)cc2C)nc1C
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13n/an/an/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL


Assay Description
pA2 is the negative log of the molar concentration required to double the agonism of opioid receptor delta 1


J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50221780
PNG
(CHEMBL3217089)
Show SMILES Cl.Cl.Cc1cc(O)cc(C)c1CC(N)C(=O)NCc1nc(O)c(CNC(=O)C(N)Cc2c(C)cc(O)cc2C)nc1C
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16n/an/an/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL




J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50221778
PNG
(CHEMBL3216392)
Show SMILES Cl.Cl.Cc1cc(O)cc(C)c1CC(N)C(=O)NCCCCc1nc(O)c(CCCCNC(=O)C(N)Cc2c(C)cc(O)cc2C)nc1C
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23n/an/an/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL


Assay Description
Compound was tested for Opioid receptor mu 1 agonism in isolated tissues from guinea pig ileum


J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50221779
PNG
(CHEMBL3215974)
Show SMILES Cl.Cl.Cc1nc(CCCNC(=O)C(N)Cc2ccc(O)cc2)c(O)nc1CCCNC(=O)C(N)Cc1ccc(O)cc1
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26n/an/an/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL




J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50221782
PNG
(CHEMBL3215530)
Show SMILES Cl.Cl.Cc1nc(CCCCNC(=O)C(N)Cc2ccc(O)cc2)c(O)nc1CCCCNC(=O)C(N)Cc1ccc(O)cc1
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70n/an/an/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL




J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50146023
PNG
(2-Amino-N-[2-(5-{2-[2-amino-3-(4-hydroxy-phenyl)-p...)
Show SMILES Cl.Cl.Cc1nc(CCNC(=O)C(N)Cc2ccc(O)cc2)c(=O)[nH]c1CCNC(=O)C(N)Cc1ccc(O)cc1
Show InChI InChI=1S/C27H34N6O5/c1-16-23(10-12-30-25(36)21(28)14-17-2-6-19(34)7-3-17)33-27(38)24(32-16)11-13-31-26(37)22(29)15-18-4-8-20(35)9-5-18/h2-9,21-22,34-35H,10-15,28-29H2,1H3,(H,30,36)(H,31,37)(H,33,38)
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309n/an/an/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity towards Opioid receptor mu 1 by displacing [3H]DAGO radioligand in rat brain P2 synaptosomes membranes.


J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50221779
PNG
(CHEMBL3215974)
Show SMILES Cl.Cl.Cc1nc(CCCNC(=O)C(N)Cc2ccc(O)cc2)c(O)nc1CCCNC(=O)C(N)Cc1ccc(O)cc1
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435n/an/an/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL




J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50146020
PNG
(2-Amino-N-(5-{[2-amino-3-(4-hydroxy-phenyl)-propio...)
Show SMILES Cl.Cl.Cc1nc(CNC(=O)C(N)Cc2ccc(O)cc2)c(=O)[nH]c1CNC(=O)C(N)Cc1ccc(O)cc1
Show InChI InChI=1S/C25H30N6O5/c1-14-21(12-28-23(34)19(26)10-15-2-6-17(32)7-3-15)31-25(36)22(30-14)13-29-24(35)20(27)11-16-4-8-18(33)9-5-16/h2-9,19-20,32-33H,10-13,26-27H2,1H3,(H,28,34)(H,29,35)(H,31,36)
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460n/an/an/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity towards Opioid receptor mu 1 by displacing [3H]DAGO radioligand in rat brain P2 synaptosomes membranes.


J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50146020
PNG
(2-Amino-N-(5-{[2-amino-3-(4-hydroxy-phenyl)-propio...)
Show SMILES Cl.Cl.Cc1nc(CNC(=O)C(N)Cc2ccc(O)cc2)c(=O)[nH]c1CNC(=O)C(N)Cc1ccc(O)cc1
Show InChI InChI=1S/C25H30N6O5/c1-14-21(12-28-23(34)19(26)10-15-2-6-17(32)7-3-15)31-25(36)22(30-14)13-29-24(35)20(27)11-16-4-8-18(33)9-5-16/h2-9,19-20,32-33H,10-13,26-27H2,1H3,(H,28,34)(H,29,35)(H,31,36)
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1.83E+3n/an/an/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity towards opioid receptor delta 1 by displacing [3H]DPDPE radioligand in rat brain P2 synaptosomes membranes.


J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50221782
PNG
(CHEMBL3215530)
Show SMILES Cl.Cl.Cc1nc(CCCCNC(=O)C(N)Cc2ccc(O)cc2)c(O)nc1CCCCNC(=O)C(N)Cc1ccc(O)cc1
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2.19E+3n/an/an/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL




J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50146023
PNG
(2-Amino-N-[2-(5-{2-[2-amino-3-(4-hydroxy-phenyl)-p...)
Show SMILES Cl.Cl.Cc1nc(CCNC(=O)C(N)Cc2ccc(O)cc2)c(=O)[nH]c1CCNC(=O)C(N)Cc1ccc(O)cc1
Show InChI InChI=1S/C27H34N6O5/c1-16-23(10-12-30-25(36)21(28)14-17-2-6-19(34)7-3-17)33-27(38)24(32-16)11-13-31-26(37)22(29)15-18-4-8-20(35)9-5-18/h2-9,21-22,34-35H,10-15,28-29H2,1H3,(H,30,36)(H,31,37)(H,33,38)
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2.90E+3n/an/an/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity towards opioid receptor delta 1 by displacing [3H]DPDPE radioligand in rat brain P2 synaptosomes membranes.


J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50062810
PNG
(3-{(S)-1-[2-(4-Carbamimidoyl-benzoylamino)-acetyl]...)
Show SMILES NC(=N)c1ccc(cc1)C(=O)NCC(=O)N1CCN(CC(O)=O)C(=O)[C@@H]1CCC(O)=O
Show InChI InChI=1S/C19H23N5O7/c20-17(21)11-1-3-12(4-2-11)18(30)22-9-14(25)24-8-7-23(10-16(28)29)19(31)13(24)5-6-15(26)27/h1-4,13H,5-10H2,(H3,20,21)(H,22,30)(H,26,27)(H,28,29)/t13-/m0/s1
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n/an/a 0.210n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia(HEL) cells.


J Med Chem 41: 489-502 (1998)


Article DOI: 10.1021/jm970235u
BindingDB Entry DOI: 10.7270/Q2571B4W
More data for this
Ligand-Target Pair
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50062797
PNG
(3-{(S)-1-[2-(4-Carbamimidoyl-benzoylamino)-acetyl]...)
Show SMILES COC(=O)CC[C@@H]1N(CCN(CC(O)=O)C1=O)C(=O)CNC(=O)c1ccc(cc1)C(N)=N
Show InChI InChI=1S/C20H25N5O7/c1-32-17(29)7-6-14-20(31)24(11-16(27)28)8-9-25(14)15(26)10-23-19(30)13-4-2-12(3-5-13)18(21)22/h2-5,14H,6-11H2,1H3,(H3,21,22)(H,23,30)(H,27,28)/t14-/m0/s1
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n/an/a 0.290n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia(HEL) cells.


J Med Chem 41: 489-502 (1998)


Article DOI: 10.1021/jm970235u
BindingDB Entry DOI: 10.7270/Q2571B4W
More data for this
Ligand-Target Pair
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50062785
PNG
(CHEMBL147976 | {4-[2-(4-Carbamimidoyl-benzoylamino...)
Show SMILES NC(=N)c1ccc(cc1)C(=O)NCC(=O)N1CCN(CC(O)=O)C(=O)C1
Show InChI InChI=1S/C16H19N5O5/c17-15(18)10-1-3-11(4-2-10)16(26)19-7-12(22)20-5-6-21(9-14(24)25)13(23)8-20/h1-4H,5-9H2,(H3,17,18)(H,19,26)(H,24,25)
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n/an/a 0.420n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia(HEL) cells.


J Med Chem 41: 489-502 (1998)


Article DOI: 10.1021/jm970235u
BindingDB Entry DOI: 10.7270/Q2571B4W
More data for this
Ligand-Target Pair
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50062783
PNG
(CHEMBL310081 | TAK-029 | {(S)-1-[2-(4-Carbamimidoy...)
Show SMILES COC(=O)C[C@@H]1N(CCN(CC(O)=O)C1=O)C(=O)CNC(=O)c1ccc(cc1)C(N)=N
Show InChI InChI=1S/C19H23N5O7/c1-31-16(28)8-13-19(30)23(10-15(26)27)6-7-24(13)14(25)9-22-18(29)12-4-2-11(3-5-12)17(20)21/h2-5,13H,6-10H2,1H3,(H3,20,21)(H,22,29)(H,26,27)/t13-/m0/s1
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n/an/a 0.490n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia(HEL) cells.


J Med Chem 41: 489-502 (1998)


Article DOI: 10.1021/jm970235u
BindingDB Entry DOI: 10.7270/Q2571B4W
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50067612
PNG
((S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-penta...)
Show SMILES CCC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@H](C=O)C(C)C
Show InChI InChI=1S/C21H28N2O4S/c1-5-15(4)20(21(25)22-18(13-24)14(2)3)23-28(26,27)19-12-8-10-16-9-6-7-11-17(16)19/h6-15,18,20,23H,5H2,1-4H3,(H,22,25)/t15?,18-,20+/m1/s1
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n/an/a 0.740n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50062803
PNG
(3-((S)-1-{2-[4-(2-Amino-ethyl)-benzoylamino]-acety...)
Show SMILES COC(=O)CC[C@@H]1N(CCN(CC(O)=O)C1=O)C(=O)CNC(=O)c1ccc(CCN)cc1
Show InChI InChI=1S/C21H28N4O7/c1-32-19(29)7-6-16-21(31)24(13-18(27)28)10-11-25(16)17(26)12-23-20(30)15-4-2-14(3-5-15)8-9-22/h2-5,16H,6-13,22H2,1H3,(H,23,30)(H,27,28)/t16-/m0/s1
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n/an/a 0.890n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia(HEL) cells.


J Med Chem 41: 489-502 (1998)


Article DOI: 10.1021/jm970235u
BindingDB Entry DOI: 10.7270/Q2571B4W
More data for this
Ligand-Target Pair
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50062789
PNG
(((S)-4-{2-[4-(2-Amino-ethyl)-benzoylamino]-acetyl}...)
Show SMILES COC(=O)C[C@@H]1N(CCN(CC(O)=O)C1=O)C(=O)CNC(=O)c1ccc(CCN)cc1
Show InChI InChI=1S/C20H26N4O7/c1-31-18(28)10-15-20(30)23(12-17(26)27)8-9-24(15)16(25)11-22-19(29)14-4-2-13(3-5-14)6-7-21/h2-5,15H,6-12,21H2,1H3,(H,22,29)(H,26,27)/t15-/m0/s1
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n/an/a 0.910n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia(HEL) cells.


J Med Chem 41: 489-502 (1998)


Article DOI: 10.1021/jm970235u
BindingDB Entry DOI: 10.7270/Q2571B4W
More data for this
Ligand-Target Pair
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50062798
PNG
(CHEMBL148010 | {(S)-4-[2-(4-Carbamimidoyl-benzoyla...)
Show SMILES NC(=O)C[C@@H]1N(CCN(CC(O)=O)C1=O)C(=O)CNC(=O)c1ccc(cc1)C(N)=N
Show InChI InChI=1S/C18H22N6O6/c19-13(25)7-12-18(30)23(9-15(27)28)5-6-24(12)14(26)8-22-17(29)11-3-1-10(2-4-11)16(20)21/h1-4,12H,5-9H2,(H2,19,25)(H3,20,21)(H,22,29)(H,27,28)/t12-/m0/s1
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n/an/a 0.920n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia(HEL) cells.


J Med Chem 41: 489-502 (1998)


Article DOI: 10.1021/jm970235u
BindingDB Entry DOI: 10.7270/Q2571B4W
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50067608
PNG
((S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-penta...)
Show SMILES CCC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C=O
Show InChI InChI=1S/C25H28N2O4S/c1-3-18(2)24(25(29)26-21(17-28)16-19-10-5-4-6-11-19)27-32(30,31)23-15-9-13-20-12-7-8-14-22(20)23/h4-15,17-18,21,24,27H,3,16H2,1-2H3,(H,26,29)/t18?,21-,24-/m0/s1
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n/an/a 0.950n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50067606
PNG
((S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-penta...)
Show SMILES CCC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@@H](CC(C)C)C=O
Show InChI InChI=1S/C22H30N2O4S/c1-5-16(4)21(22(26)23-18(14-25)13-15(2)3)24-29(27,28)20-12-8-10-17-9-6-7-11-19(17)20/h6-12,14-16,18,21,24H,5,13H2,1-4H3,(H,23,26)/t16?,18-,21-/m0/s1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50067604
PNG
((S)-N-[(R)-1-Formyl-2-(1H-indol-3-yl)-ethyl]-3-met...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C26H27N3O4S/c1-17(2)25(29-34(32,33)24-13-7-9-18-8-3-4-11-22(18)24)26(31)28-20(16-30)14-19-15-27-23-12-6-5-10-21(19)23/h3-13,15-17,20,25,27,29H,14H2,1-2H3,(H,28,31)/t20-,25+/m1/s1
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n/an/a 0.970n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50422277
PNG
(CHEMBL118402)
Show SMILES NC(=N)c1ccc(cc1)C(=O)NCC(=O)N1CCN(CC(O)=O)C(=O)[C@@H]1CC(O)=O
Show InChI InChI=1S/C18H21N5O7/c19-16(20)10-1-3-11(4-2-10)17(29)21-8-13(24)23-6-5-22(9-15(27)28)18(30)12(23)7-14(25)26/h1-4,12H,5-9H2,(H3,19,20)(H,21,29)(H,25,26)(H,27,28)/t12-/m0/s1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia(HEL) cells.


J Med Chem 41: 489-502 (1998)


Article DOI: 10.1021/jm970235u
BindingDB Entry DOI: 10.7270/Q2571B4W
More data for this
Ligand-Target Pair
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50062782
PNG
(3-((S)-1-{2-[4-(2-Amino-ethyl)-benzoylamino]-acety...)
Show SMILES NCCc1ccc(cc1)C(=O)NCC(=O)N1CCN(CC(O)=O)C(=O)[C@@H]1CCC(O)=O
Show InChI InChI=1S/C20H26N4O7/c21-8-7-13-1-3-14(4-2-13)19(30)22-11-16(25)24-10-9-23(12-18(28)29)20(31)15(24)5-6-17(26)27/h1-4,15H,5-12,21H2,(H,22,30)(H,26,27)(H,28,29)/t15-/m0/s1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia(HEL) cells.


J Med Chem 41: 489-502 (1998)


Article DOI: 10.1021/jm970235u
BindingDB Entry DOI: 10.7270/Q2571B4W
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)
BDBM50221787
PNG
(CHEMBL3216418)
Show SMILES Cl.Cl.Cc1cc(O)cc(C)c1CC(N)C(=O)NCCCc1nc(O)c(CCCNC(=O)C(N)Cc2c(C)cc(O)cc2C)nc1C
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n/an/a 1.30n/an/an/an/an/an/a



National Institutes of Environmental Health Sciences

Curated by ChEMBL




J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50067613
PNG
((S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-penta...)
Show SMILES CCC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C=O
Show InChI InChI=1S/C25H28N2O5S/c1-3-17(2)24(25(30)26-20(16-28)15-18-11-13-21(29)14-12-18)27-33(31,32)23-10-6-8-19-7-4-5-9-22(19)23/h4-14,16-17,20,24,27,29H,3,15H2,1-2H3,(H,26,30)/t17?,20-,24-/m0/s1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50062787
PNG
((4-{2-[4-(2-Amino-ethyl)-benzoylamino]-acetyl}-2-o...)
Show SMILES NCCc1ccc(cc1)C(=O)NCC(=O)N1CCN(CC(O)=O)C(=O)C1
Show InChI InChI=1S/C17H22N4O5/c18-6-5-12-1-3-13(4-2-12)17(26)19-9-14(22)20-7-8-21(11-16(24)25)15(23)10-20/h1-4H,5-11,18H2,(H,19,26)(H,24,25)
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia(HEL) cells.


J Med Chem 41: 489-502 (1998)


Article DOI: 10.1021/jm970235u
BindingDB Entry DOI: 10.7270/Q2571B4W
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50369397
PNG
(CHEMBL1790993)
Show SMILES CC[C@@H](C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C27H29N3O4S/c1-3-18(2)26(30-35(33,34)25-14-8-10-19-9-4-5-12-23(19)25)27(32)29-21(17-31)15-20-16-28-24-13-7-6-11-22(20)24/h4-14,16-18,21,26,28,30H,3,15H2,1-2H3,(H,29,32)/t18-,21-,26+/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)
BDBM50221778
PNG
(CHEMBL3216392)
Show SMILES Cl.Cl.Cc1cc(O)cc(C)c1CC(N)C(=O)NCCCCc1nc(O)c(CCCCNC(=O)C(N)Cc2c(C)cc(O)cc2C)nc1C
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National Institutes of Environmental Health Sciences

Curated by ChEMBL




J Med Chem 47: 2599-610 (2004)


Article DOI: 10.1021/jm0304616
BindingDB Entry DOI: 10.7270/Q2RB755V
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50369410
PNG
(CHEMBL1790989)
Show SMILES CC[C@@H](C)[C@H](NC(=O)Nc1cccc2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C28H30N4O3/c1-3-18(2)26(32-28(35)31-25-14-8-10-19-9-4-5-11-22(19)25)27(34)30-21(17-33)15-20-16-29-24-13-7-6-12-23(20)24/h4-14,16-18,21,26,29H,3,15H2,1-2H3,(H,30,34)(H2,31,32,35)/t18-,21-,26+/m1/s1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50369405
PNG
(CHEMBL1790991)
Show SMILES CC[C@@H](C)[C@H](NC(=O)Nc1ccccc1C(F)(F)F)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C25H27F3N4O3/c1-3-15(2)22(32-24(35)31-21-11-7-5-9-19(21)25(26,27)28)23(34)30-17(14-33)12-16-13-29-20-10-6-4-8-18(16)20/h4-11,13-15,17,22,29H,3,12H2,1-2H3,(H,30,34)(H2,31,32,35)/t15-,17-,22+/m1/s1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50369397
PNG
(CHEMBL1790993)
Show SMILES CC[C@@H](C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C27H29N3O4S/c1-3-18(2)26(30-35(33,34)25-14-8-10-19-9-4-5-12-23(19)25)27(32)29-21(17-31)15-20-16-28-24-13-7-6-11-22(20)24/h4-14,16-18,21,26,28,30H,3,15H2,1-2H3,(H,29,32)/t18-,21-,26+/m1/s1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Compound was measured for inhibition of collagenolytic of human Cathepsin L


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50062791
PNG
(CHEMBL146393 | {(S)-3-Benzyl-4-[2-(4-carbamimidoyl...)
Show SMILES NC(=N)c1ccc(cc1)C(=O)NCC(=O)N1CCN(CC(O)=O)C(=O)[C@@H]1Cc1ccccc1
Show InChI InChI=1S/C23H25N5O5/c24-21(25)16-6-8-17(9-7-16)22(32)26-13-19(29)28-11-10-27(14-20(30)31)23(33)18(28)12-15-4-2-1-3-5-15/h1-9,18H,10-14H2,(H3,24,25)(H,26,32)(H,30,31)/t18-/m0/s1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia(HEL) cells.


J Med Chem 41: 489-502 (1998)


Article DOI: 10.1021/jm970235u
BindingDB Entry DOI: 10.7270/Q2571B4W
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50369402
PNG
(CHEMBL1790996)
Show SMILES CC[C@@H](C)[C@H](NC(=O)c1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C24H27N3O3/c1-3-16(2)22(27-23(29)17-9-5-4-6-10-17)24(30)26-19(15-28)13-18-14-25-21-12-8-7-11-20(18)21/h4-12,14-16,19,22,25H,3,13H2,1-2H3,(H,26,30)(H,27,29)/t16-,19-,22+/m1/s1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50369400
PNG
(CHEMBL1791000)
Show SMILES CC[C@@H](C)[C@H](NC(=S)Nc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C24H28N4O2S/c1-3-16(2)22(28-24(31)27-18-9-5-4-6-10-18)23(30)26-19(15-29)13-17-14-25-21-12-8-7-11-20(17)21/h4-12,14-16,19,22,25H,3,13H2,1-2H3,(H,26,30)(H2,27,28,31)/t16-,19-,22+/m1/s1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50067597
PNG
((S)-4-Methyl-2-(naphthalene-1-sulfonylamino)-penta...)
Show SMILES CC(C)C[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C27H29N3O4S/c1-18(2)14-25(30-35(33,34)26-13-7-9-19-8-3-4-11-23(19)26)27(32)29-21(17-31)15-20-16-28-24-12-6-5-10-22(20)24/h3-13,16-18,21,25,28,30H,14-15H2,1-2H3,(H,29,32)/t21-,25+/m1/s1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50369403
PNG
(CHEMBL1790995)
Show SMILES CC[C@@H](C)[C@H](NC(=S)NCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C25H30N4O2S/c1-3-17(2)23(29-25(32)27-14-18-9-5-4-6-10-18)24(31)28-20(16-30)13-19-15-26-22-12-8-7-11-21(19)22/h4-12,15-17,20,23,26H,3,13-14H2,1-2H3,(H,28,31)(H2,27,29,32)/t17-,20-,23+/m1/s1
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n/an/a 2.20n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50369398
PNG
(CHEMBL1790999)
Show SMILES CC[C@@H](C)[C@H](NS(=O)(=O)c1ccc(C)cc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C24H29N3O4S/c1-4-17(3)23(27-32(30,31)20-11-9-16(2)10-12-20)24(29)26-19(15-28)13-18-14-25-22-8-6-5-7-21(18)22/h5-12,14-15,17,19,23,25,27H,4,13H2,1-3H3,(H,26,29)/t17-,19-,23+/m1/s1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50062781
PNG
(((S)-1-{2-[4-(2-Amino-ethyl)-benzoylamino]-acetyl}...)
Show SMILES NCCc1ccc(cc1)C(=O)NCC(=O)N1CCN(CC(O)=O)C(=O)[C@@H]1CC(O)=O
Show InChI InChI=1S/C19H24N4O7/c20-6-5-12-1-3-13(4-2-12)18(29)21-10-15(24)23-8-7-22(11-17(27)28)19(30)14(23)9-16(25)26/h1-4,14H,5-11,20H2,(H,21,29)(H,25,26)(H,27,28)/t14-/m0/s1
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n/an/a 2.5n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia(HEL) cells.


J Med Chem 41: 489-502 (1998)


Article DOI: 10.1021/jm970235u
BindingDB Entry DOI: 10.7270/Q2571B4W
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50286441
PNG
((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C20H38N6O5/c1-11(2)9-15(24-13(5)27)17(28)26-16(10-12(3)4)18(29)25-14(19(30)31)7-6-8-23-20(21)22/h11-12,14-16H,6-10H2,1-5H3,(H,24,27)(H,25,29)(H,26,28)(H,30,31)(H4,21,22,23)/t14-,15-,16-/m0/s1
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n/an/a 2.5n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Compound was measured for inhibition of collagenolytic of human Cathepsin L


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50067594
PNG
((S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-penta...)
Show SMILES CCC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@@H](C)C=O
Show InChI InChI=1S/C19H24N2O4S/c1-4-13(2)18(19(23)20-14(3)12-22)21-26(24,25)17-11-7-9-15-8-5-6-10-16(15)17/h5-14,18,21H,4H2,1-3H3,(H,20,23)/t13?,14-,18-/m0/s1
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n/an/a 3.10n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50369406
PNG
(CHEMBL1791001)
Show SMILES CC[C@@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C22H31N3O4/c1-6-14(2)19(25-21(28)29-22(3,4)5)20(27)24-16(13-26)11-15-12-23-18-10-8-7-9-17(15)18/h7-10,12-14,16,19,23H,6,11H2,1-5H3,(H,24,27)(H,25,28)/t14-,16-,19+/m1/s1
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n/an/a 3.30n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50369408
PNG
(CHEMBL1790997)
Show SMILES CC[C@@H](C)[C@H](NC(=O)Nc1cccc(C)c1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C25H30N4O3/c1-4-17(3)23(29-25(32)28-19-9-7-8-16(2)12-19)24(31)27-20(15-30)13-18-14-26-22-11-6-5-10-21(18)22/h5-12,14-15,17,20,23,26H,4,13H2,1-3H3,(H,27,31)(H2,28,29,32)/t17-,20-,23+/m1/s1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50369409
PNG
(CHEMBL1791004)
Show SMILES CC[C@@H](C)[C@H](NS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C27H29N3O4S/c1-3-18(2)26(30-35(33,34)23-13-12-19-8-4-5-9-20(19)15-23)27(32)29-22(17-31)14-21-16-28-25-11-7-6-10-24(21)25/h4-13,15-18,22,26,28,30H,3,14H2,1-2H3,(H,29,32)/t18-,22-,26+/m1/s1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM50067614
PNG
((S)-N-[(R)-1-Formyl-2-(1H-indol-3-yl)-ethyl]-3-(na...)
Show SMILES COC(=O)C[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C=O
Show InChI InChI=1S/C26H25N3O6S/c1-35-25(31)14-23(29-36(33,34)24-12-6-8-17-7-2-3-10-21(17)24)26(32)28-19(16-30)13-18-15-27-22-11-5-4-9-20(18)22/h2-12,15-16,19,23,27,29H,13-14H2,1H3,(H,28,32)/t19-,23+/m1/s1
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n/an/a 4.30n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L.


J Med Chem 41: 4301-8 (1998)


Article DOI: 10.1021/jm9803065
BindingDB Entry DOI: 10.7270/Q2VQ33CX
More data for this
Ligand-Target Pair
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