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Compile Data Set for Download or QSAR

Found 905 hits with Last Name = 'gao' and Initial = 'j'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373621
PNG
(CHEMBL403414)
Show SMILES CN(C1CCN(CC1)S(C)(=O)=O)C(=O)Nc1ccc(cc1)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C20H23F2N3O3S/c1-24(19-7-9-25(10-8-19)29(2,27)28)20(26)23-18-5-3-14(4-6-18)15-11-16(21)13-17(22)12-15/h3-6,11-13,19H,7-10H2,1-2H3,(H,23,26)
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0.400n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50085393
PNG
((2R,3R)-2-(3-Carbamimidoyl-benzyl)-3-[(3'-carbamoy...)
Show SMILES COC(=O)[C@H](Cc1cccc(c1)C(N)=N)[C@@H](C)NC(=O)c1ccc(cc1)-c1cccc(c1)C(N)=O
Show InChI InChI=1S/C27H28N4O4/c1-16(23(27(34)35-2)14-17-5-3-7-21(13-17)24(28)29)31-26(33)19-11-9-18(10-12-19)20-6-4-8-22(15-20)25(30)32/h3-13,15-16,23H,14H2,1-2H3,(H3,28,29)(H2,30,32)(H,31,33)/t16-,23-/m1/s1
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0.5n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of coagulation factor Xa.


Bioorg Med Chem Lett 10: 217-21 (2000)


BindingDB Entry DOI: 10.7270/Q2M32TZG
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50085402
PNG
(4-{4-[3-(5-Carbamimidoyl-2-hydroxy-phenyl)-allylca...)
Show SMILES NC(=N)c1ccc(O)c(\C=C\CNC(=O)c2ccc(cc2)-c2ccnc(c2)C(N)=O)c1
Show InChI InChI=1S/C23H21N5O3/c24-21(25)18-7-8-20(29)17(12-18)2-1-10-28-23(31)15-5-3-14(4-6-15)16-9-11-27-19(13-16)22(26)30/h1-9,11-13,29H,10H2,(H3,24,25)(H2,26,30)(H,28,31)/b2-1+
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0.75n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of coagulation factor Xa.


Bioorg Med Chem Lett 10: 217-21 (2000)


BindingDB Entry DOI: 10.7270/Q2M32TZG
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373623
PNG
(CHEMBL404461)
Show SMILES CCS(=O)(=O)N1CCC(CC1)N(C)C(=O)N[C@H]1CC[C@@H](CC1)c1cc(F)cc(F)c1 |wU:16.16,wD:19.23,(10.08,-2.96,;10.08,-1.42,;8.75,-.65,;7.98,-1.98,;9.53,.68,;7.42,.12,;6.08,-.64,;4.76,.13,;4.77,1.66,;6.09,2.44,;7.42,1.67,;3.43,2.43,;3.43,3.97,;2.1,1.66,;2.1,.12,;.77,2.43,;-.57,1.66,;-.56,.13,;-1.9,-.64,;-3.24,.13,;-3.23,1.68,;-1.9,2.44,;-4.57,-.63,;-5.91,.15,;-7.24,-.61,;-8.57,.16,;-7.25,-2.16,;-5.91,-2.93,;-5.91,-4.47,;-4.58,-2.16,)|
Show InChI InChI=1S/C21H31F2N3O3S/c1-3-30(28,29)26-10-8-20(9-11-26)25(2)21(27)24-19-6-4-15(5-7-19)16-12-17(22)14-18(23)13-16/h12-15,19-20H,3-11H2,1-2H3,(H,24,27)/t15-,19-
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0.75n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373639
PNG
(CHEMBL428423)
Show SMILES CN(C1CCN(CC1)S(C)(=O)=O)C(=O)NC1CCN(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C19H28Cl2N4O3S/c1-23(17-5-9-25(10-6-17)29(2,27)28)19(26)22-16-3-7-24(8-4-16)18-12-14(20)11-15(21)13-18/h11-13,16-17H,3-10H2,1-2H3,(H,22,26)
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1.10n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373624
PNG
(CHEMBL255353)
Show SMILES CN(C1CCN(CC1)S(C)(=O)=O)C(=O)N[C@H]1CC[C@@H](CC1)c1cc(F)cc(F)c1 |wU:15.15,wD:18.22,(28.66,-44.4,;28.66,-45.94,;29.99,-46.71,;29.98,-48.24,;31.3,-49.01,;32.64,-48.25,;32.65,-46.7,;31.31,-45.93,;33.97,-49.02,;35.3,-49.79,;33.2,-50.35,;34.75,-47.69,;27.32,-46.71,;27.32,-48.25,;25.99,-45.94,;24.66,-46.71,;24.66,-48.24,;23.32,-49.01,;21.99,-48.24,;21.99,-46.69,;23.32,-45.93,;20.65,-49,;19.32,-48.22,;17.98,-48.98,;16.65,-48.21,;17.98,-50.53,;19.32,-51.3,;19.32,-52.84,;20.65,-50.53,)|
Show InChI InChI=1S/C20H29F2N3O3S/c1-24(19-7-9-25(10-8-19)29(2,27)28)20(26)23-18-5-3-14(4-6-18)15-11-16(21)13-17(22)12-15/h11-14,18-19H,3-10H2,1-2H3,(H,23,26)/t14-,18-
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1.20n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373625
PNG
(CHEMBL403918)
Show SMILES CCC(=O)N1CCC(CC1)N(C)C(=O)N[C@H]1CC[C@@H](CC1)c1cc(F)cc(F)c1 |wU:15.15,wD:18.22,(36.07,-39.93,;34.73,-39.16,;33.4,-39.92,;33.39,-41.46,;32.07,-39.15,;30.73,-39.91,;29.4,-39.14,;29.42,-37.61,;30.74,-36.83,;32.07,-37.6,;28.08,-36.84,;28.08,-35.3,;26.75,-37.61,;26.75,-39.15,;25.41,-36.84,;24.08,-37.61,;24.08,-39.14,;22.74,-39.91,;21.41,-39.14,;21.42,-37.59,;22.75,-36.83,;20.07,-39.9,;20.07,-41.43,;18.74,-42.2,;18.74,-43.74,;17.4,-41.43,;17.41,-39.88,;16.08,-39.11,;18.74,-39.12,)|
Show InChI InChI=1S/C22H31F2N3O2/c1-3-21(28)27-10-8-20(9-11-27)26(2)22(29)25-19-6-4-15(5-7-19)16-12-17(23)14-18(24)13-16/h12-15,19-20H,3-11H2,1-2H3,(H,25,29)/t15-,19-
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1.5n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373626
PNG
(CHEMBL257940)
Show SMILES CN(C1CCN(CC1)C(C)=O)C(=O)N[C@H]1CC[C@@H](CC1)c1cc(F)cc(F)c1 |wU:14.14,wD:17.21,(3.32,-35.53,;3.32,-37.07,;4.66,-37.84,;4.65,-39.37,;5.97,-40.14,;7.31,-39.38,;7.31,-37.84,;5.98,-37.06,;8.64,-40.15,;9.98,-39.39,;8.64,-41.69,;1.99,-37.84,;1.99,-39.38,;.66,-37.07,;-.68,-37.84,;-.67,-39.38,;-2.01,-40.14,;-3.35,-39.37,;-3.34,-37.83,;-2.01,-37.06,;-4.68,-40.13,;-4.69,-41.67,;-6.02,-42.43,;-6.02,-43.97,;-7.36,-41.66,;-7.35,-40.12,;-8.68,-39.34,;-6.01,-39.35,)|
Show InChI InChI=1S/C21H29F2N3O2/c1-14(27)26-9-7-20(8-10-26)25(2)21(28)24-19-5-3-15(4-6-19)16-11-17(22)13-18(23)12-16/h11-13,15,19-20H,3-10H2,1-2H3,(H,24,28)/t15-,19-
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1.80n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373622
PNG
(CHEMBL255147)
Show SMILES CCCC(=O)N1CCC(CC1)N(C)C(=O)N[C@H]1CC[C@@H](CC1)c1cc(F)cc(F)c1 |wU:16.16,wD:19.23,(12.07,-14.83,;12.08,-13.29,;13.41,-12.52,;13.42,-10.98,;14.76,-10.22,;12.09,-10.21,;10.75,-10.97,;9.43,-10.2,;9.44,-8.67,;10.76,-7.89,;12.09,-8.67,;8.11,-7.9,;8.11,-6.36,;6.77,-8.67,;6.77,-10.21,;5.44,-7.9,;4.11,-8.67,;4.11,-10.21,;2.77,-10.97,;1.44,-10.2,;1.44,-8.66,;2.77,-7.89,;.1,-10.96,;-1.23,-10.18,;-2.57,-10.95,;-3.9,-10.17,;-2.57,-12.49,;-1.23,-13.26,;-1.23,-14.8,;.1,-12.49,)|
Show InChI InChI=1S/C23H33F2N3O2/c1-3-4-22(29)28-11-9-21(10-12-28)27(2)23(30)26-20-7-5-16(6-8-20)17-13-18(24)15-19(25)14-17/h13-16,20-21H,3-12H2,1-2H3,(H,26,30)/t16-,20-
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2n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50085405
PNG
(2'-Sulfamoyl-biphenyl-4-carboxylic acid [3-(5-carb...)
Show SMILES NC(=N)c1ccc(O)c(\C=C\CNC(=O)c2ccc(cc2)-c2ccccc2S(N)(=O)=O)c1
Show InChI InChI=1S/C23H22N4O4S/c24-22(25)18-11-12-20(28)17(14-18)4-3-13-27-23(29)16-9-7-15(8-10-16)19-5-1-2-6-21(19)32(26,30)31/h1-12,14,28H,13H2,(H3,24,25)(H,27,29)(H2,26,30,31)/b4-3+
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2n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of coagulation factor Xa.


Bioorg Med Chem Lett 10: 217-21 (2000)


BindingDB Entry DOI: 10.7270/Q2M32TZG
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373622
PNG
(CHEMBL255147)
Show SMILES CCCC(=O)N1CCC(CC1)N(C)C(=O)N[C@H]1CC[C@@H](CC1)c1cc(F)cc(F)c1 |wU:16.16,wD:19.23,(12.07,-14.83,;12.08,-13.29,;13.41,-12.52,;13.42,-10.98,;14.76,-10.22,;12.09,-10.21,;10.75,-10.97,;9.43,-10.2,;9.44,-8.67,;10.76,-7.89,;12.09,-8.67,;8.11,-7.9,;8.11,-6.36,;6.77,-8.67,;6.77,-10.21,;5.44,-7.9,;4.11,-8.67,;4.11,-10.21,;2.77,-10.97,;1.44,-10.2,;1.44,-8.66,;2.77,-7.89,;.1,-10.96,;-1.23,-10.18,;-2.57,-10.95,;-3.9,-10.17,;-2.57,-12.49,;-1.23,-13.26,;-1.23,-14.8,;.1,-12.49,)|
Show InChI InChI=1S/C23H33F2N3O2/c1-3-4-22(29)28-11-9-21(10-12-28)27(2)23(30)26-20-7-5-16(6-8-20)17-13-18(24)15-19(25)14-17/h13-16,20-21H,3-12H2,1-2H3,(H,26,30)/t16-,20-
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2.40n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373649
PNG
(CHEMBL257022)
Show SMILES CC(C)C(=O)N1CCC(CC1)N(C)C(=O)NC1CCN(CC1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C22H32F2N4O2/c1-15(2)21(29)28-10-6-19(7-11-28)26(3)22(30)25-18-4-8-27(9-5-18)20-13-16(23)12-17(24)14-20/h12-15,18-19H,4-11H2,1-3H3,(H,25,30)
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2.60n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373655
PNG
(CHEMBL257707)
Show SMILES CCS(=O)(=O)N1CCC(CC1)N(C)C(=O)NC1CCN(CC1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C20H30F2N4O3S/c1-3-30(28,29)26-10-6-18(7-11-26)24(2)20(27)23-17-4-8-25(9-5-17)19-13-15(21)12-16(22)14-19/h12-14,17-18H,3-11H2,1-2H3,(H,23,27)
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2.80n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373656
PNG
(CHEMBL428953)
Show SMILES CN(C1CCN(CC1)S(C)(=O)=O)C(=O)NC1CCN(CC1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C19H28F2N4O3S/c1-23(17-5-9-25(10-6-17)29(2,27)28)19(26)22-16-3-7-24(8-4-16)18-12-14(20)11-15(21)13-18/h11-13,16-17H,3-10H2,1-2H3,(H,22,26)
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3.20n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373653
PNG
(CHEMBL429679)
Show SMILES CC(C)S(=O)(=O)N1CCC(CC1)N(C)C(=O)NC1CCN(CC1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C21H32F2N4O3S/c1-15(2)31(29,30)27-10-6-19(7-11-27)25(3)21(28)24-18-4-8-26(9-5-18)20-13-16(22)12-17(23)14-20/h12-15,18-19H,4-11H2,1-3H3,(H,24,28)
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3.20n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373654
PNG
(CHEMBL257708)
Show SMILES CCCS(=O)(=O)N1CCC(CC1)N(C)C(=O)NC1CCN(CC1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C21H32F2N4O3S/c1-3-12-31(29,30)27-10-6-19(7-11-27)25(2)21(28)24-18-4-8-26(9-5-18)20-14-16(22)13-17(23)15-20/h13-15,18-19H,3-12H2,1-2H3,(H,24,28)
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3.40n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50076089
PNG
((3S,3aR,4R,4aS,8aR,9aS)-3-Methyl-4-[2-((R)-1-methy...)
Show SMILES C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](\C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12
Show InChI InChI=1S/C22H35NO2/c1-14-7-6-9-17(23(14)3)11-12-19-18-10-5-4-8-16(18)13-20-21(19)15(2)25-22(20)24/h11-12,14-21H,4-10,13H2,1-3H3/b12-11+/t14-,15-,16+,17+,18-,19+,20-,21+/m0/s1
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4.70n/an/an/an/an/an/an/an/a



Ghent University

Curated by ChEMBL




Bioorg Med Chem Lett 12: 1909-12 (2002)


BindingDB Entry DOI: 10.7270/Q20V8FZ6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50085390
PNG
(Biphenyl-3,4'-dicarboxylic acid 3-amide 4'-{[(E)-3...)
Show SMILES NC(=N)c1ccc(O)c(\C=C\CNC(=O)c2ccc(cc2)-c2cccc(c2)C(N)=O)c1
Show InChI InChI=1S/C24H22N4O3/c25-22(26)19-10-11-21(29)18(14-19)5-2-12-28-24(31)16-8-6-15(7-9-16)17-3-1-4-20(13-17)23(27)30/h1-11,13-14,29H,12H2,(H3,25,26)(H2,27,30)(H,28,31)/b5-2+
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5n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of coagulation factor Xa.


Bioorg Med Chem Lett 10: 217-21 (2000)


BindingDB Entry DOI: 10.7270/Q2M32TZG
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50085406
PNG
((2R,3R)-3-[(Biphenyl-4-carbonyl)-amino]-2-(3-carba...)
Show SMILES COC(=O)[C@H](Cc1cccc(c1)C(N)=N)[C@@H](C)NC(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H27N3O3/c1-17(23(26(31)32-2)16-18-7-6-10-22(15-18)24(27)28)29-25(30)21-13-11-20(12-14-21)19-8-4-3-5-9-19/h3-15,17,23H,16H2,1-2H3,(H3,27,28)(H,29,30)/t17-,23-/m1/s1
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5n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of coagulation factor Xa.


Bioorg Med Chem Lett 10: 217-21 (2000)


BindingDB Entry DOI: 10.7270/Q2M32TZG
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373650
PNG
(CHEMBL257248)
Show SMILES CCCC(=O)N1CCC(CC1)N(C)C(=O)NC1CCN(CC1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C22H32F2N4O2/c1-3-4-21(29)28-11-7-19(8-12-28)26(2)22(30)25-18-5-9-27(10-6-18)20-14-16(23)13-17(24)15-20/h13-15,18-19H,3-12H2,1-2H3,(H,25,30)
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5.90n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373651
PNG
(CHEMBL257457)
Show SMILES CCC(=O)N1CCC(CC1)N(C)C(=O)NC1CCN(CC1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C21H30F2N4O2/c1-3-20(28)27-10-6-18(7-11-27)25(2)21(29)24-17-4-8-26(9-5-17)19-13-15(22)12-16(23)14-19/h12-14,17-18H,3-11H2,1-2H3,(H,24,29)
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6.30n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50085392
PNG
(Biphenyl-3,4'-dicarboxylic acid 3-amide 4'-{[3-(5-...)
Show SMILES NC(=N)c1ccc(O)c(CCCNC(=O)c2ccc(cc2)-c2cccc(c2)C(N)=O)c1
Show InChI InChI=1S/C24H24N4O3/c25-22(26)19-10-11-21(29)18(14-19)5-2-12-28-24(31)16-8-6-15(7-9-16)17-3-1-4-20(13-17)23(27)30/h1,3-4,6-11,13-14,29H,2,5,12H2,(H3,25,26)(H2,27,30)(H,28,31)
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7n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of coagulation factor Xa.


Bioorg Med Chem Lett 10: 217-21 (2000)


BindingDB Entry DOI: 10.7270/Q2M32TZG
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373652
PNG
(CHEMBL401726)
Show SMILES CN(C1CCN(CC1)C(C)=O)C(=O)NC1CCN(CC1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C20H28F2N4O2/c1-14(27)25-9-5-18(6-10-25)24(2)20(28)23-17-3-7-26(8-4-17)19-12-15(21)11-16(22)13-19/h11-13,17-18H,3-10H2,1-2H3,(H,23,28)
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7.40n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM50076089
PNG
((3S,3aR,4R,4aS,8aR,9aS)-3-Methyl-4-[2-((R)-1-methy...)
Show SMILES C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](\C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12
Show InChI InChI=1S/C22H35NO2/c1-14-7-6-9-17(23(14)3)11-12-19-18-10-5-4-8-16(18)13-20-21(19)15(2)25-22(20)24/h11-12,14-21H,4-10,13H2,1-3H3/b12-11+/t14-,15-,16+,17+,18-,19+,20-,21+/m0/s1
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8.70n/an/an/an/an/an/an/an/a



Ghent University

Curated by ChEMBL




Bioorg Med Chem Lett 12: 1909-12 (2002)


BindingDB Entry DOI: 10.7270/Q20V8FZ6
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373642
PNG
(CHEMBL273182)
Show SMILES CN(C1CCN(CC1)S(C)(=O)=O)C(=O)NC1CCN(CC1)c1cccc(Br)c1
Show InChI InChI=1S/C19H29BrN4O3S/c1-22(17-8-12-24(13-9-17)28(2,26)27)19(25)21-16-6-10-23(11-7-16)18-5-3-4-15(20)14-18/h3-5,14,16-17H,6-13H2,1-2H3,(H,21,25)
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8.80n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50085388
PNG
(3'-Sulfamoyl-biphenyl-4-carboxylic acid [3-(5-carb...)
Show SMILES NC(=N)c1ccc(O)c(\C=C\CNC(=O)c2ccc(cc2)-c2cccc(c2)S(N)(=O)=O)c1
Show InChI InChI=1S/C23H22N4O4S/c24-22(25)19-10-11-21(28)18(13-19)4-2-12-27-23(29)16-8-6-15(7-9-16)17-3-1-5-20(14-17)32(26,30)31/h1-11,13-14,28H,12H2,(H3,24,25)(H,27,29)(H2,26,30,31)/b4-2+
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9n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of coagulation factor Xa.


Bioorg Med Chem Lett 10: 217-21 (2000)


BindingDB Entry DOI: 10.7270/Q2M32TZG
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50095778
PNG
(4-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2...)
Show SMILES Cn1c(nc2c(N)nc(nc12)C#CC(C)(C)O)-c1cccc(F)c1
Show InChI InChI=1S/C17H16FN5O/c1-17(2,24)8-7-12-20-14(19)13-16(21-12)23(3)15(22-13)10-5-4-6-11(18)9-10/h4-6,9,24H,1-3H3,(H2,19,20,21)
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9.10n/an/an/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Binding Affinity towards Adenosine A2A receptor expressed in HEK-293 cells versus [3H]-CGS-21,680


J Med Chem 44: 170-9 (2001)


BindingDB Entry DOI: 10.7270/Q2R49Q0X
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50095790
PNG
(1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2...)
Show SMILES Cn1c(nc2c(N)nc(nc12)C#CC1(O)CCCC1)-c1cccc(F)c1
Show InChI InChI=1S/C19H18FN5O/c1-25-17(12-5-4-6-13(20)11-12)24-15-16(21)22-14(23-18(15)25)7-10-19(26)8-2-3-9-19/h4-6,11,26H,2-3,8-9H2,1H3,(H2,21,22,23)
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9.80n/an/an/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Binding Affinity towards Adenosine A2A receptor expressed in HEK-293 cells versus [3H]-CGS-21,680


J Med Chem 44: 170-9 (2001)


BindingDB Entry DOI: 10.7270/Q2R49Q0X
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50076089
PNG
((3S,3aR,4R,4aS,8aR,9aS)-3-Methyl-4-[2-((R)-1-methy...)
Show SMILES C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](\C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12
Show InChI InChI=1S/C22H35NO2/c1-14-7-6-9-17(23(14)3)11-12-19-18-10-5-4-8-16(18)13-20-21(19)15(2)25-22(20)24/h11-12,14-21H,4-10,13H2,1-3H3/b12-11+/t14-,15-,16+,17+,18-,19+,20-,21+/m0/s1
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10n/an/an/an/an/an/an/an/a



Ghent University

Curated by ChEMBL




Bioorg Med Chem Lett 12: 1909-12 (2002)


BindingDB Entry DOI: 10.7270/Q20V8FZ6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM50076089
PNG
((3S,3aR,4R,4aS,8aR,9aS)-3-Methyl-4-[2-((R)-1-methy...)
Show SMILES C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](\C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12
Show InChI InChI=1S/C22H35NO2/c1-14-7-6-9-17(23(14)3)11-12-19-18-10-5-4-8-16(18)13-20-21(19)15(2)25-22(20)24/h11-12,14-21H,4-10,13H2,1-3H3/b12-11+/t14-,15-,16+,17+,18-,19+,20-,21+/m0/s1
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11n/an/an/an/an/an/an/an/a



Ghent University

Curated by ChEMBL




Bioorg Med Chem Lett 12: 1909-12 (2002)


BindingDB Entry DOI: 10.7270/Q20V8FZ6
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50095786
PNG
(1-(6-Amino-8-furan-2-yl-9-methyl-9H-purin-2-ylethy...)
Show SMILES Cn1c(nc2c(N)nc(nc12)C#CC1(O)CCCCC1)-c1ccco1
Show InChI InChI=1S/C18H19N5O2/c1-23-16(12-6-5-11-25-12)22-14-15(19)20-13(21-17(14)23)7-10-18(24)8-3-2-4-9-18/h5-6,11,24H,2-4,8-9H2,1H3,(H2,19,20,21)
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11n/an/an/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Binding Affinity towards Adenosine A2A receptor expressed in HEK-293 cells versus [3H]-CGS-21,680


J Med Chem 44: 170-9 (2001)


BindingDB Entry DOI: 10.7270/Q2R49Q0X
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50085400
PNG
(4'-Sulfamoyl-biphenyl-4-carboxylic acid [(E)-3-(5-...)
Show SMILES NC(=N)c1ccc(O)c(\C=C\CNC(=O)c2ccc(cc2)-c2ccc(cc2)S(N)(=O)=O)c1
Show InChI InChI=1S/C23H22N4O4S/c24-22(25)19-9-12-21(28)18(14-19)2-1-13-27-23(29)17-5-3-15(4-6-17)16-7-10-20(11-8-16)32(26,30)31/h1-12,14,28H,13H2,(H3,24,25)(H,27,29)(H2,26,30,31)/b2-1+
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12n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of coagulation factor Xa.


Bioorg Med Chem Lett 10: 217-21 (2000)


BindingDB Entry DOI: 10.7270/Q2M32TZG
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50095787
PNG
(3-[6-Amino-2-(1-hydroxy-cyclohexylethynyl)-9-methy...)
Show SMILES Cn1c(nc2c(N)nc(nc12)C#CC1(O)CCCCC1)-c1cccc(c1)C#N
Show InChI InChI=1S/C21H20N6O/c1-27-19(15-7-5-6-14(12-15)13-22)26-17-18(23)24-16(25-20(17)27)8-11-21(28)9-3-2-4-10-21/h5-7,12,28H,2-4,9-10H2,1H3,(H2,23,24,25)
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13n/an/an/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Binding Affinity towards Adenosine A2A receptor expressed in HEK-293 cells versus [3H]-CGS-21,680


J Med Chem 44: 170-9 (2001)


BindingDB Entry DOI: 10.7270/Q2R49Q0X
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373643
PNG
(CHEMBL255352)
Show SMILES CN(C1CCN(CC1)S(C)(=O)=O)C(=O)NC1CCN(CC1)c1cccc(Cl)c1
Show InChI InChI=1S/C19H29ClN4O3S/c1-22(17-8-12-24(13-9-17)28(2,26)27)19(25)21-16-6-10-23(11-7-16)18-5-3-4-15(20)14-18/h3-5,14,16-17H,6-13H2,1-2H3,(H,21,25)
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13n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (Human))
BDBM50059376
PNG
(9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]triazolo[5,1-...)
Show SMILES COC(=O)C1=C2C=CN(C)C=C2c2nc(nn2C1)-c1ccccc1 |c:4,6,10|
Show InChI InChI=1S/C18H16N4O2/c1-21-9-8-13-14(10-21)17-19-16(12-6-4-3-5-7-12)20-22(17)11-15(13)18(23)24-2/h3-10H,11H2,1-2H3
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13n/an/an/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards adenosine A3 receptor expressed in HEK-293 cells versus [125I]-AB-MECA


J Med Chem 44: 170-9 (2001)


BindingDB Entry DOI: 10.7270/Q2R49Q0X
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50095784
PNG
(1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2...)
Show SMILES CCC(O)(CC)C#Cc1nc(N)c2nc(-c3cccc(F)c3)n(C)c2n1
Show InChI InChI=1S/C19H20FN5O/c1-4-19(26,5-2)10-9-14-22-16(21)15-18(23-14)25(3)17(24-15)12-7-6-8-13(20)11-12/h6-8,11,26H,4-5H2,1-3H3,(H2,21,22,23)
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13n/an/an/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Binding Affinity towards Adenosine A2A receptor expressed in HEK-293 cells versus [3H]-CGS-21,680


J Med Chem 44: 170-9 (2001)


BindingDB Entry DOI: 10.7270/Q2R49Q0X
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50095793
PNG
(1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2...)
Show SMILES Cn1c(nc2c(N)nc(nc12)C#CC1(O)CCCCC1)-c1cccc(F)c1
Show InChI InChI=1S/C20H20FN5O/c1-26-18(13-6-5-7-14(21)12-13)25-16-17(22)23-15(24-19(16)26)8-11-20(27)9-3-2-4-10-20/h5-7,12,27H,2-4,9-10H2,1H3,(H2,22,23,24)
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14n/an/an/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Binding Affinity towards Adenosine A1 receptor expressed in CHO-K1 cells versus [3H]-CCPA


J Med Chem 44: 170-9 (2001)


BindingDB Entry DOI: 10.7270/Q2R49Q0X
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50095788
PNG
(1-[6-Amino-8-(2-fluoro-phenyl)-9-methyl-9H-purin-2...)
Show SMILES Cn1c(nc2c(N)nc(nc12)C#CC1(O)CCCCC1)-c1ccccc1F
Show InChI InChI=1S/C20H20FN5O/c1-26-18(13-7-3-4-8-14(13)21)25-16-17(22)23-15(24-19(16)26)9-12-20(27)10-5-2-6-11-20/h3-4,7-8,27H,2,5-6,10-11H2,1H3,(H2,22,23,24)
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15n/an/an/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Binding Affinity towards Adenosine A2A receptor expressed in HEK-293 cells versus [3H]-CGS-21,680


J Med Chem 44: 170-9 (2001)


BindingDB Entry DOI: 10.7270/Q2R49Q0X
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50095793
PNG
(1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2...)
Show SMILES Cn1c(nc2c(N)nc(nc12)C#CC1(O)CCCCC1)-c1cccc(F)c1
Show InChI InChI=1S/C20H20FN5O/c1-26-18(13-6-5-7-14(21)12-13)25-16-17(22)23-15(24-19(16)26)8-11-20(27)9-3-2-4-10-20/h5-7,12,27H,2-4,9-10H2,1H3,(H2,22,23,24)
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16n/an/an/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Binding Affinity towards Adenosine A2A receptor expressed in HEK-293 cells versus [3H]-CGS-21,680


J Med Chem 44: 170-9 (2001)


BindingDB Entry DOI: 10.7270/Q2R49Q0X
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50079652
PNG
((E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(...)
Show SMILES OCC[C@H]1CCCCN1C(=O)\C=C\c1c(nn2ccccc12)-c1ccccc1
Show InChI InChI=1S/C23H25N3O2/c27-17-14-19-10-4-6-15-25(19)22(28)13-12-20-21-11-5-7-16-26(21)24-23(20)18-8-2-1-3-9-18/h1-3,5,7-9,11-13,16,19,27H,4,6,10,14-15,17H2/b13-12+/t19-/m1/s1
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18n/an/an/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Binding Affinity towards Adenosine A1 receptor expressed in CHO-K1 cells versus [3H]-CCPA


J Med Chem 44: 170-9 (2001)


BindingDB Entry DOI: 10.7270/Q2R49Q0X
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50095781
PNG
(1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2...)
Show SMILES Cn1c(nc2c(N)nc(nc12)C#CC1(O)CCCCCC1)-c1cccc(F)c1
Show InChI InChI=1S/C21H22FN5O/c1-27-19(14-7-6-8-15(22)13-14)26-17-18(23)24-16(25-20(17)27)9-12-21(28)10-4-2-3-5-11-21/h6-8,13,28H,2-5,10-11H2,1H3,(H2,23,24,25)
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19n/an/an/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Binding Affinity towards Adenosine A2A receptor expressed in HEK-293 cells versus [3H]-CGS-21,680


J Med Chem 44: 170-9 (2001)


BindingDB Entry DOI: 10.7270/Q2R49Q0X
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50095788
PNG
(1-[6-Amino-8-(2-fluoro-phenyl)-9-methyl-9H-purin-2...)
Show SMILES Cn1c(nc2c(N)nc(nc12)C#CC1(O)CCCCC1)-c1ccccc1F
Show InChI InChI=1S/C20H20FN5O/c1-26-18(13-7-3-4-8-14(13)21)25-16-17(22)23-15(24-19(16)26)9-12-20(27)10-5-2-6-11-20/h3-4,7-8,27H,2,5-6,10-11H2,1H3,(H2,22,23,24)
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19n/an/an/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Binding Affinity towards Adenosine A1 receptor expressed in CHO-K1 cells versus [3H]-CCPA


J Med Chem 44: 170-9 (2001)


BindingDB Entry DOI: 10.7270/Q2R49Q0X
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50085401
PNG
(CHEMBL421676 | N-[(E)-3-(5-Carbamimidoyl-2-hydroxy...)
Show SMILES NC(=N)c1ccc(O)c(C=CCNC(=O)c2ccc(cc2)-c2c[nH]cn2)c1 |w:9.8|
Show InChI InChI=1S/C20H19N5O2/c21-19(22)16-7-8-18(26)15(10-16)2-1-9-24-20(27)14-5-3-13(4-6-14)17-11-23-12-25-17/h1-8,10-12,26H,9H2,(H3,21,22)(H,23,25)(H,24,27)
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19n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of coagulation factor Xa.


Bioorg Med Chem Lett 10: 217-21 (2000)


BindingDB Entry DOI: 10.7270/Q2M32TZG
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373637
PNG
(CHEMBL404398)
Show SMILES CN(C1CCN(CC1)S(C)(=O)=O)C(=O)NC1CCN(CC1)c1cccc(C)c1
Show InChI InChI=1S/C20H32N4O3S/c1-16-5-4-6-19(15-16)23-11-7-17(8-12-23)21-20(25)22(2)18-9-13-24(14-10-18)28(3,26)27/h4-6,15,17-18H,7-14H2,1-3H3,(H,21,25)
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20n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50085396
PNG
(Biphenyl-4,4'-dicarboxylic acid 4-amide 4'-{[3-(5-...)
Show SMILES NC(=N)c1ccc(O)c(\C=C\CNC(=O)c2ccc(cc2)-c2ccc(cc2)C(N)=O)c1
Show InChI InChI=1S/C24H22N4O3/c25-22(26)20-11-12-21(29)19(14-20)2-1-13-28-24(31)18-9-5-16(6-10-18)15-3-7-17(8-4-15)23(27)30/h1-12,14,29H,13H2,(H3,25,26)(H2,27,30)(H,28,31)/b2-1+
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20n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of coagulation factor Xa.


Bioorg Med Chem Lett 10: 217-21 (2000)


BindingDB Entry DOI: 10.7270/Q2M32TZG
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50095790
PNG
(1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2...)
Show SMILES Cn1c(nc2c(N)nc(nc12)C#CC1(O)CCCC1)-c1cccc(F)c1
Show InChI InChI=1S/C19H18FN5O/c1-25-17(12-5-4-6-13(20)11-12)24-15-16(21)22-14(23-18(15)25)7-10-19(26)8-2-3-9-19/h4-6,11,26H,2-3,8-9H2,1H3,(H2,21,22,23)
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20n/an/an/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Binding Affinity towards Adenosine A1 receptor expressed in CHO-K1 cells versus [3H]-CCPA


J Med Chem 44: 170-9 (2001)


BindingDB Entry DOI: 10.7270/Q2R49Q0X
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50095786
PNG
(1-(6-Amino-8-furan-2-yl-9-methyl-9H-purin-2-ylethy...)
Show SMILES Cn1c(nc2c(N)nc(nc12)C#CC1(O)CCCCC1)-c1ccco1
Show InChI InChI=1S/C18H19N5O2/c1-23-16(12-6-5-11-25-12)22-14-15(19)20-13(21-17(14)23)7-10-18(24)8-3-2-4-9-18/h5-6,11,24H,2-4,8-9H2,1H3,(H2,19,20,21)
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25n/an/an/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Binding Affinity towards Adenosine A1 receptor expressed in CHO-K1 cells versus [3H]-CCPA


J Med Chem 44: 170-9 (2001)


BindingDB Entry DOI: 10.7270/Q2R49Q0X
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50095781
PNG
(1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2...)
Show SMILES Cn1c(nc2c(N)nc(nc12)C#CC1(O)CCCCCC1)-c1cccc(F)c1
Show InChI InChI=1S/C21H22FN5O/c1-27-19(14-7-6-8-15(22)13-14)26-17-18(23)24-16(25-20(17)27)9-12-21(28)10-4-2-3-5-11-21/h6-8,13,28H,2-5,10-11H2,1H3,(H2,23,24,25)
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27n/an/an/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Binding Affinity towards Adenosine A1 receptor expressed in CHO-K1 cells versus [3H]-CCPA


J Med Chem 44: 170-9 (2001)


BindingDB Entry DOI: 10.7270/Q2R49Q0X
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50373636
PNG
(CHEMBL404304)
Show SMILES CN(C1CCN(CC1)S(C)(=O)=O)C(=O)NC1CCN(CC1)c1cccc(c1)C#N
Show InChI InChI=1S/C20H29N5O3S/c1-23(18-8-12-25(13-9-18)29(2,27)28)20(26)22-17-6-10-24(11-7-17)19-5-3-4-16(14-19)15-21/h3-5,14,17-18H,6-13H2,1-2H3,(H,22,26)
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27n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125]PYY from human chimeric NPY Y5 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 18: 1146-50 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.132
BindingDB Entry DOI: 10.7270/Q27D2W1W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (Human))
BDBM50095784
PNG
(1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2...)
Show SMILES CCC(O)(CC)C#Cc1nc(N)c2nc(-c3cccc(F)c3)n(C)c2n1
Show InChI InChI=1S/C19H20FN5O/c1-4-19(26,5-2)10-9-14-22-16(21)15-18(23-14)25(3)17(24-15)12-7-6-8-13(20)11-12/h6-8,11,26H,4-5H2,1-3H3,(H2,21,22,23)
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29n/an/an/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Binding Affinity towards Adenosine A1 receptor expressed in CHO-K1 cells versus [3H]-CCPA


J Med Chem 44: 170-9 (2001)


BindingDB Entry DOI: 10.7270/Q2R49Q0X
More data for this
Ligand-Target Pair
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