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Compile Data Set for Download or QSAR

Found 138 hits with Last Name = 'gloanec' and Initial = 'p'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50256003
PNG
(4-[2-Amino-5-oxo-3,5-dihydro-imidazol-(4)-ylidene]...)
Show SMILES NC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3c(Br)csc3c12 |w:3.2,t:1|
Show InChI InChI=1S/C13H10BrN5O2S/c14-5-3-22-10-6-4(7-12(21)19-13(15)18-7)1-2-16-11(20)9(6)17-8(5)10/h3,17H,1-2H2,(H,16,20)(H3,15,18,19,21)
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n/an/a 14n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50256004
PNG
(4-[2-Amino-5-oxo-3,5-dihydro-imidazol-(4)-ylidene]...)
Show SMILES NC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3c(csc3c12)C#N |w:3.2,t:1|
Show InChI InChI=1S/C14H10N6O2S/c15-3-5-4-23-11-7-6(9-13(22)20-14(16)19-9)1-2-17-12(21)10(7)18-8(5)11/h4,18H,1-2H2,(H,17,21)(H3,16,19,20,22)
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n/an/a 29n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50256043
PNG
((Z)-3-bromohymenialdisine | CHEMBL480350 | Hymenia...)
Show SMILES NC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c(Br)c(Br)c12 |w:3.2,t:1|
Show InChI InChI=1S/C11H9Br2N5O2/c12-5-4-3(6-10(20)18-11(14)17-6)1-2-15-9(19)7(4)16-8(5)13/h16H,1-2H2,(H,15,19)(H3,14,17,18,20)
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n/an/a 100n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (Human))
BDBM50193234
PNG
(CHEMBL211973 | {(R)-1-[2-(4-carbamimidoyl-benzylca...)
Show SMILES NC(=N)c1ccc(CNC(=O)C2(Cc3ccccc3C2)NC(=O)[C@@H](CC2CCCCC2)NCC(O)=O)cc1
Show InChI InChI=1S/C29H37N5O4/c30-26(31)21-12-10-20(11-13-21)17-33-28(38)29(15-22-8-4-5-9-23(22)16-29)34-27(37)24(32-18-25(35)36)14-19-6-2-1-3-7-19/h4-5,8-13,19,24,32H,1-3,6-7,14-18H2,(H3,30,31)(H,33,38)(H,34,37)(H,35,36)/t24-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of human aPC


J Med Chem 49: 5047-50 (2006)


Article DOI: 10.1021/jm0606950
BindingDB Entry DOI: 10.7270/Q2H994VN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50256000
PNG
(4-[2-Amino-5-oxo-3,5-dihydro-imidazol-(4)-ylidene]...)
Show SMILES NC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3c(Cl)csc3c12 |w:3.2,t:1|
Show InChI InChI=1S/C13H10ClN5O2S/c14-5-3-22-10-6-4(7-12(21)19-13(15)18-7)1-2-16-11(20)9(6)17-8(5)10/h3,17H,1-2H2,(H,16,20)(H3,15,18,19,21)
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n/an/a 140n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50256025
PNG
(4-[2-Amino-5-oxo-3,5-dihydro-imidazol-(4)-ylidene]...)
Show SMILES NC(=O)c1csc2c3c([nH]c12)C(=O)NCCC3=C1N=C(N)NC1=O |w:17.20,t:21|
Show InChI InChI=1S/C14H12N6O3S/c15-11(21)5-3-24-10-6-4(8-13(23)20-14(16)19-8)1-2-17-12(22)9(6)18-7(5)10/h3,18H,1-2H2,(H2,15,21)(H,17,22)(H3,16,19,20,23)
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n/an/a 150n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50256047
PNG
(4-[2-Amino-5-oxo-3,5-dihydro-imidazol-(4)-ylidene]...)
Show SMILES NC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3ccsc3c12 |w:3.2,t:1|
Show InChI InChI=1S/C13H11N5O2S/c14-13-17-8(12(20)18-13)5-1-3-15-11(19)9-7(5)10-6(16-9)2-4-21-10/h2,4,16H,1,3H2,(H,15,19)(H3,14,17,18,20)
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n/an/a 150n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50256028
PNG
(4-[2-Amino-4-oxo-4H-thiazol-(5)-ylidene]-4,6,7,9-t...)
Show SMILES NC1=NC(=O)C(S1)=C1CCNC(=O)c2[nH]c3ccsc3c12 |w:5.5,t:1|
Show InChI InChI=1S/C13H10N4O2S2/c14-13-17-12(19)9(21-13)5-1-3-15-11(18)8-7(5)10-6(16-8)2-4-20-10/h2,4,16H,1,3H2,(H,15,18)(H2,14,17,19)
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n/an/a 180n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50256029
PNG
(4-[2-Amino-4-oxo-4H-thiazol-(5)-ylidene]-1-bromo-4...)
Show SMILES NC1=NC(=O)C(S1)=C1CCNC(=O)c2[nH]c3c(Br)csc3c12 |w:5.5,t:1|
Show InChI InChI=1S/C13H9BrN4O2S2/c14-5-3-21-10-6-4(9-12(20)18-13(15)22-9)1-2-16-11(19)8(6)17-7(5)10/h3,17H,1-2H2,(H,16,19)(H2,15,18,20)
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Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50293389
PNG
(CHEMBL553237 | {(3S)-5-[2-({4-[Amino(imino)methyl]...)
Show SMILES NC(=N)c1ccc(CNC(=O)CN2c3cc(CC(O)=O)ccc3SC[C@@H](NS(=O)(=O)Cc3ccccc3)C2=O)cc1 |r|
Show InChI InChI=1S/C28H29N5O6S2/c29-27(30)21-9-6-18(7-10-21)14-31-25(34)15-33-23-12-20(13-26(35)36)8-11-24(23)40-16-22(28(33)37)32-41(38,39)17-19-4-2-1-3-5-19/h1-12,22,32H,13-17H2,(H3,29,30)(H,31,34)(H,35,36)/t22-/m1/s1
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Universit£ Montpellier 1

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a by spectrometry


Bioorg Med Chem Lett 19: 1386-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.039
BindingDB Entry DOI: 10.7270/Q2G73DRB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50256027
PNG
(10-[2-Amino-5-oxo-3,5-dihydro-imidazol-(4)-ylidene...)
Show SMILES NC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3c4ccccc4sc3c12 |w:3.2,t:1|
Show InChI InChI=1S/C17H13N5O2S/c18-17-21-12(16(24)22-17)8-5-6-19-15(23)13-10(8)14-11(20-13)7-3-1-2-4-9(7)25-14/h1-4,20H,5-6H2,(H,19,23)(H3,18,21,22,24)
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n/an/a 230n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (Human))
BDBM50193230
PNG
(CHEMBL215639 | {(R)-1-[2-(4-carbamimidoyl-benzylca...)
Show SMILES CC(C)[C@@H](NCC(O)=O)C(=O)NC1(Cc2ccc3ccccc3c2C1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C29H33N5O4/c1-17(2)25(32-16-24(35)36)27(37)34-29(28(38)33-15-18-7-9-20(10-8-18)26(30)31)13-21-12-11-19-5-3-4-6-22(19)23(21)14-29/h3-12,17,25,32H,13-16H2,1-2H3,(H3,30,31)(H,33,38)(H,34,37)(H,35,36)/t25-,29?/m1/s1
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n/an/a 250n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of human aPC


J Med Chem 49: 5047-50 (2006)


Article DOI: 10.1021/jm0606950
BindingDB Entry DOI: 10.7270/Q2H994VN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50256008
PNG
(CHEMBL517241 | {5-[1-Bromo-8-oxo-6,7,8,9-tetrahydr...)
Show SMILES OC(=O)CNC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3c(Br)csc3c12 |w:7.7,t:5|
Show InChI InChI=1S/C15H12BrN5O4S/c16-6-4-26-12-8-5(1-2-17-13(24)11(8)19-10(6)12)9-14(25)21-15(20-9)18-3-7(22)23/h4,19H,1-3H2,(H,17,24)(H,22,23)(H2,18,20,21,25)
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n/an/a 260n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50256030
PNG
(1-Bromo-4-[2-(2-hydroxy-ethylamino)-5-oxo-3,5-dihy...)
Show SMILES OCCNC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3c(Br)csc3c12 |w:6.5,t:4|
Show InChI InChI=1S/C15H14BrN5O3S/c16-7-5-25-12-8-6(1-2-17-13(23)11(8)19-10(7)12)9-14(24)21-15(20-9)18-3-4-22/h5,19,22H,1-4H2,(H,17,23)(H2,18,20,21,24)
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n/an/a 280n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50256048
PNG
(4-[2-Amino-5-oxo-3,5-dihydro-imidazol-(4)-ylidene]...)
Show SMILES NC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3cc(Cl)sc3c12 |w:3.2,t:1|
Show InChI InChI=1S/C13H10ClN5O2S/c14-6-3-5-10(22-6)7-4(8-12(21)19-13(15)18-8)1-2-16-11(20)9(7)17-5/h3,17H,1-2H2,(H,16,20)(H3,15,18,19,21)
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Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM16591
PNG
((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)
Show SMILES NC1=NC(=O)C(N1)=C1CCNC(=O)c2[nH]ccc12 |w:7.18,t:1|
Show InChI InChI=1S/C11H11N5O2/c12-11-15-8(10(18)16-11)6-2-4-14-9(17)7-5(6)1-3-13-7/h1,3,13H,2,4H2,(H,14,17)(H3,12,15,16,18)
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n/an/a 330n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (Human))
BDBM50193224
PNG
(((R)-1-{[(S)-(4-carbamimidoyl-benzylcarbamoyl)-ind...)
Show SMILES CC(C)[C@@H](NCC(O)=O)C(=O)N[C@@H](C1Cc2ccccc2C1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C26H33N5O4/c1-15(2)22(29-14-21(32)33)26(35)31-23(20-11-18-5-3-4-6-19(18)12-20)25(34)30-13-16-7-9-17(10-8-16)24(27)28/h3-10,15,20,22-23,29H,11-14H2,1-2H3,(H3,27,28)(H,30,34)(H,31,35)(H,32,33)/t22-,23+/m1/s1
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Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of human aPC


J Med Chem 49: 5047-50 (2006)


Article DOI: 10.1021/jm0606950
BindingDB Entry DOI: 10.7270/Q2H994VN
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (Human))
BDBM50193229
PNG
(CHEMBL215357 | {(R)-1-[2-(4-carbamimidoyl-benzylca...)
Show SMILES CC(C)[C@@H](NCC(O)=O)C(=O)NC1(Cc2cccc3cccc(C1)c23)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C29H33N5O4/c1-17(2)25(32-16-23(35)36)27(37)34-29(28(38)33-15-18-9-11-20(12-10-18)26(30)31)13-21-7-3-5-19-6-4-8-22(14-29)24(19)21/h3-12,17,25,32H,13-16H2,1-2H3,(H3,30,31)(H,33,38)(H,34,37)(H,35,36)/t25-/m1/s1
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Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of human aPC


J Med Chem 49: 5047-50 (2006)


Article DOI: 10.1021/jm0606950
BindingDB Entry DOI: 10.7270/Q2H994VN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50256002
PNG
(4-[2-Amino-5-oxo-3,5-dihydro-imidazol-(4)-ylidene]...)
Show SMILES NC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3cc(Br)sc3c12 |w:3.2,t:1|
Show InChI InChI=1S/C13H10BrN5O2S/c14-6-3-5-10(22-6)7-4(8-12(21)19-13(15)18-8)1-2-16-11(20)9(7)17-5/h3,17H,1-2H2,(H,16,20)(H3,15,18,19,21)
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n/an/a 460n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50025098
PNG
(CHEMBL332551)
Show SMILES Nc1nc(c(O)[nH]1)C1=C2C(=Nc3ccccc23)C(=O)NCC1 |c:10,t:8|
Show InChI InChI=1S/C15H13N5O2/c16-15-19-11(14(22)20-15)8-5-6-17-13(21)12-10(8)7-3-1-2-4-9(7)18-12/h1-4,22H,5-6H2,(H,17,21)(H3,16,19,20)
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n/an/a 470n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (Human))
BDBM50193242
PNG
(CHEMBL212789 | {(R)-1-[(S)-1-(4-carbamimidoyl-benz...)
Show SMILES CC(C)[C@@H](NCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C24H31N5O4/c1-15(2)21(27-14-20(30)31)24(33)29-19(12-16-6-4-3-5-7-16)23(32)28-13-17-8-10-18(11-9-17)22(25)26/h3-11,15,19,21,27H,12-14H2,1-2H3,(H3,25,26)(H,28,32)(H,29,33)(H,30,31)/t19-,21+/m0/s1
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n/an/a 710n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of human aPC


J Med Chem 49: 5047-50 (2006)


Article DOI: 10.1021/jm0606950
BindingDB Entry DOI: 10.7270/Q2H994VN
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (Human))
BDBM50193241
PNG
(CHEMBL380157 | {(R)-1-[2-(4-carbamimidoyl-benzylca...)
Show SMILES CC(C)C[C@@H](NCC(O)=O)C(=O)NC1(Cc2ccccc2C1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C26H33N5O4/c1-16(2)11-21(29-15-22(32)33)24(34)31-26(12-19-5-3-4-6-20(19)13-26)25(35)30-14-17-7-9-18(10-8-17)23(27)28/h3-10,16,21,29H,11-15H2,1-2H3,(H3,27,28)(H,30,35)(H,31,34)(H,32,33)/t21-/m1/s1
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n/an/a 750n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of human aPC


J Med Chem 49: 5047-50 (2006)


Article DOI: 10.1021/jm0606950
BindingDB Entry DOI: 10.7270/Q2H994VN
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM50193230
PNG
(CHEMBL215639 | {(R)-1-[2-(4-carbamimidoyl-benzylca...)
Show SMILES CC(C)[C@@H](NCC(O)=O)C(=O)NC1(Cc2ccc3ccccc3c2C1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C29H33N5O4/c1-17(2)25(32-16-24(35)36)27(37)34-29(28(38)33-15-18-7-9-20(10-8-18)26(30)31)13-21-12-11-19-5-3-4-6-22(19)23(21)14-29/h3-12,17,25,32H,13-16H2,1-2H3,(H3,30,31)(H,33,38)(H,34,37)(H,35,36)/t25-,29?/m1/s1
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n/an/a 770n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of human thrombin activity


J Med Chem 49: 5047-50 (2006)


Article DOI: 10.1021/jm0606950
BindingDB Entry DOI: 10.7270/Q2H994VN
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM50293383
PNG
(2-[(3S)-3-[Benzylsulfonylamino]-7-(3-nitrophenyl)-...)
Show SMILES NC(=N)c1ccc(CNC(=O)CN2c3cc(ccc3SC[C@@H](NS(=O)(=O)Cc3ccccc3)C2=O)-c2cccc(c2)[N+]([O-])=O)cc1 |r|
Show InChI InChI=1S/C32H30N6O6S2/c33-31(34)23-11-9-21(10-12-23)17-35-30(39)18-37-28-16-25(24-7-4-8-26(15-24)38(41)42)13-14-29(28)45-19-27(32(37)40)36-46(43,44)20-22-5-2-1-3-6-22/h1-16,27,36H,17-20H2,(H3,33,34)(H,35,39)/t27-/m1/s1
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n/an/a 790n/an/an/an/an/an/a



Universit£ Montpellier 1

Curated by ChEMBL


Assay Description
Inhibition of human factor 2a by spectrophotometry


Bioorg Med Chem Lett 19: 1386-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.039
BindingDB Entry DOI: 10.7270/Q2G73DRB
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50293387
PNG
(2-[(3S)-8-Aminomethyl-3-[benzylsulfonylamino]-4-ox...)
Show SMILES NCc1ccc2N(CC(=O)NCc3ccc(cc3)C(N)=N)C(=O)[C@@H](CSc2c1)NS(=O)(=O)Cc1ccccc1 |r|
Show InChI InChI=1S/C27H30N6O4S2/c28-13-20-8-11-23-24(12-20)38-16-22(32-39(36,37)17-19-4-2-1-3-5-19)27(35)33(23)15-25(34)31-14-18-6-9-21(10-7-18)26(29)30/h1-12,22,32H,13-17,28H2,(H3,29,30)(H,31,34)/t22-/m1/s1
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n/an/a 800n/an/an/an/an/an/a



Universit£ Montpellier 1

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a by spectrometry


Bioorg Med Chem Lett 19: 1386-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.039
BindingDB Entry DOI: 10.7270/Q2G73DRB
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (Human))
BDBM50193240
PNG
(CHEMBL426333 | {(R)-1-[2-(4-carbamimidoyl-benzylca...)
Show SMILES CC(C)[C@@H](NCC(O)=O)C(=O)NC1(Cc2ccccc2C1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C25H31N5O4/c1-15(2)21(28-14-20(31)32)23(33)30-25(11-18-5-3-4-6-19(18)12-25)24(34)29-13-16-7-9-17(10-8-16)22(26)27/h3-10,15,21,28H,11-14H2,1-2H3,(H3,26,27)(H,29,34)(H,30,33)(H,31,32)/t21-/m1/s1
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n/an/a 800n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of human aPC


J Med Chem 49: 5047-50 (2006)


Article DOI: 10.1021/jm0606950
BindingDB Entry DOI: 10.7270/Q2H994VN
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (Human))
BDBM50193243
PNG
(({(R)-[2-(4-carbamimidoyl-benzylcarbamoyl)-indan-2...)
Show SMILES NC(=N)c1ccc(CNC(=O)C2(Cc3ccccc3C2)NC(=O)[C@H](NCC(O)=O)C2CCCCC2)cc1
Show InChI InChI=1S/C28H35N5O4/c29-25(30)20-12-10-18(11-13-20)16-32-27(37)28(14-21-8-4-5-9-22(21)15-28)33-26(36)24(31-17-23(34)35)19-6-2-1-3-7-19/h4-5,8-13,19,24,31H,1-3,6-7,14-17H2,(H3,29,30)(H,32,37)(H,33,36)(H,34,35)/t24-/m1/s1
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n/an/a 820n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of human aPC


J Med Chem 49: 5047-50 (2006)


Article DOI: 10.1021/jm0606950
BindingDB Entry DOI: 10.7270/Q2H994VN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50256001
PNG
(4-[2-Amino-5-oxo-3,5-dihydro-imidazol-(4)-ylidene]...)
Show SMILES NC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3c(Cl)c(Cl)sc3c12 |w:3.2,t:1|
Show InChI InChI=1S/C13H9Cl2N5O2S/c14-5-8-9(23-10(5)15)4-3(6-12(22)20-13(16)19-6)1-2-17-11(21)7(4)18-8/h18H,1-2H2,(H,17,21)(H3,16,19,20,22)
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n/an/a 890n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50293384
PNG
(2-Amino-3-{(3S)-5-[2-({4-[amino(imino)methyl]benzy...)
Show SMILES NC(Cc1ccc2SC[C@@H](NS(=O)(=O)Cc3ccccc3)C(=O)N(CC(=O)NCc3ccc(cc3)C(N)=N)c2c1)C(O)=O |r|
Show InChI InChI=1S/C29H32N6O6S2/c30-22(29(38)39)12-20-8-11-25-24(13-20)35(15-26(36)33-14-18-6-9-21(10-7-18)27(31)32)28(37)23(16-42-25)34-43(40,41)17-19-4-2-1-3-5-19/h1-11,13,22-23,34H,12,14-17,30H2,(H3,31,32)(H,33,36)(H,38,39)/t22?,23-/m1/s1
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n/an/a 1.05E+3n/an/an/an/an/an/a



Universit£ Montpellier 1

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a by spectrometry


Bioorg Med Chem Lett 19: 1386-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.039
BindingDB Entry DOI: 10.7270/Q2G73DRB
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (Human))
BDBM50193235
PNG
(CHEMBL215870 | {(R)-1-[6-(4-carbamimidoyl-benzylca...)
Show SMILES CC(C)[C@@H](NCC(O)=O)C(=O)NC1(Cc2cccnc2C1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C24H30N6O4/c1-14(2)20(28-13-19(31)32)22(33)30-24(10-17-4-3-9-27-18(17)11-24)23(34)29-12-15-5-7-16(8-6-15)21(25)26/h3-9,14,20,28H,10-13H2,1-2H3,(H3,25,26)(H,29,34)(H,30,33)(H,31,32)/t20-,24?/m1/s1
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n/an/a 1.07E+3n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of human aPC


J Med Chem 49: 5047-50 (2006)


Article DOI: 10.1021/jm0606950
BindingDB Entry DOI: 10.7270/Q2H994VN
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (Human))
BDBM50193228
PNG
(CHEMBL215556 | {(R)-1-[2-(4-carbamimidoyl-benzylca...)
Show SMILES CCC(C)C[C@@H](NCC(O)=O)C(=O)NC1(Cc2ccccc2C1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C27H35N5O4/c1-3-17(2)12-22(30-16-23(33)34)25(35)32-27(13-20-6-4-5-7-21(20)14-27)26(36)31-15-18-8-10-19(11-9-18)24(28)29/h4-11,17,22,30H,3,12-16H2,1-2H3,(H3,28,29)(H,31,36)(H,32,35)(H,33,34)/t17?,22-/m1/s1
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n/an/a 1.12E+3n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of human aPC


J Med Chem 49: 5047-50 (2006)


Article DOI: 10.1021/jm0606950
BindingDB Entry DOI: 10.7270/Q2H994VN
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (Human))
BDBM50193235
PNG
(CHEMBL215870 | {(R)-1-[6-(4-carbamimidoyl-benzylca...)
Show SMILES CC(C)[C@@H](NCC(O)=O)C(=O)NC1(Cc2cccnc2C1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C24H30N6O4/c1-14(2)20(28-13-19(31)32)22(33)30-24(10-17-4-3-9-27-18(17)11-24)23(34)29-12-15-5-7-16(8-6-15)21(25)26/h3-9,14,20,28H,10-13H2,1-2H3,(H3,25,26)(H,29,34)(H,30,33)(H,31,32)/t20-,24?/m1/s1
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n/an/a 1.14E+3n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of human aPC


J Med Chem 49: 5047-50 (2006)


Article DOI: 10.1021/jm0606950
BindingDB Entry DOI: 10.7270/Q2H994VN
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM50193234
PNG
(CHEMBL211973 | {(R)-1-[2-(4-carbamimidoyl-benzylca...)
Show SMILES NC(=N)c1ccc(CNC(=O)C2(Cc3ccccc3C2)NC(=O)[C@@H](CC2CCCCC2)NCC(O)=O)cc1
Show InChI InChI=1S/C29H37N5O4/c30-26(31)21-12-10-20(11-13-21)17-33-28(38)29(15-22-8-4-5-9-23(22)16-29)34-27(37)24(32-18-25(35)36)14-19-6-2-1-3-7-19/h4-5,8-13,19,24,32H,1-3,6-7,14-18H2,(H3,30,31)(H,33,38)(H,34,37)(H,35,36)/t24-/m1/s1
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n/an/a 1.25E+3n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of human thrombin activity


J Med Chem 49: 5047-50 (2006)


Article DOI: 10.1021/jm0606950
BindingDB Entry DOI: 10.7270/Q2H994VN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50256026
PNG
(4-[2-Amino-5-oxo-3,5-dihydro-imidazol-(4)-ylidene]...)
Show SMILES NC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3c(csc3c12)-c1ccccc1 |w:3.3,t:1|
Show InChI InChI=1S/C19H15N5O2S/c20-19-23-14(18(26)24-19)10-6-7-21-17(25)15-12(10)16-13(22-15)11(8-27-16)9-4-2-1-3-5-9/h1-5,8,22H,6-7H2,(H,21,25)(H3,20,23,24,26)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Coagulation factor VII/tissue factor


(Homo sapiens (Human))
BDBM50293385
PNG
(2-[(3S)-7-[2-Aminoethyl]-3-[benzylsulfonylamino]-4...)
Show SMILES NCCc1ccc2SC[C@@H](NS(=O)(=O)Cc3ccccc3)C(=O)N(CC(=O)NCc3ccc(cc3)C(N)=N)c2c1 |r|
Show InChI InChI=1S/C28H32N6O4S2/c29-13-12-19-8-11-25-24(14-19)34(16-26(35)32-15-20-6-9-22(10-7-20)27(30)31)28(36)23(17-39-25)33-40(37,38)18-21-4-2-1-3-5-21/h1-11,14,23,33H,12-13,15-18,29H2,(H3,30,31)(H,32,35)/t23-/m1/s1
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n/an/a 1.32E+3n/an/an/an/an/an/a



Universit£ Montpellier 1

Curated by ChEMBL


Assay Description
Inhibition of human tissue factor/factor 7a


Bioorg Med Chem Lett 19: 1386-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.039
BindingDB Entry DOI: 10.7270/Q2G73DRB
More data for this
Ligand-Target Pair
Coagulation factor VII/tissue factor


(Homo sapiens (Human))
BDBM50293384
PNG
(2-Amino-3-{(3S)-5-[2-({4-[amino(imino)methyl]benzy...)
Show SMILES NC(Cc1ccc2SC[C@@H](NS(=O)(=O)Cc3ccccc3)C(=O)N(CC(=O)NCc3ccc(cc3)C(N)=N)c2c1)C(O)=O |r|
Show InChI InChI=1S/C29H32N6O6S2/c30-22(29(38)39)12-20-8-11-25-24(13-20)35(15-26(36)33-14-18-6-9-21(10-7-18)27(31)32)28(37)23(16-42-25)34-43(40,41)17-19-4-2-1-3-5-19/h1-11,13,22-23,34H,12,14-17,30H2,(H3,31,32)(H,33,36)(H,38,39)/t22?,23-/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Universit£ Montpellier 1

Curated by ChEMBL


Assay Description
Inhibition of human tissue factor/factor 7a


Bioorg Med Chem Lett 19: 1386-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.039
BindingDB Entry DOI: 10.7270/Q2G73DRB
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50293391
PNG
(2-[(3S)-7-Amino-3-[benzylsulfonylamino]-4-oxo-3,4-...)
Show SMILES NC(=N)c1ccc(CNC(=O)CN2c3cc(N)ccc3SC[C@@H](NS(=O)(=O)Cc3ccccc3)C2=O)cc1 |r|
Show InChI InChI=1S/C26H28N6O4S2/c27-20-10-11-23-22(12-20)32(14-24(33)30-13-17-6-8-19(9-7-17)25(28)29)26(34)21(15-37-23)31-38(35,36)16-18-4-2-1-3-5-18/h1-12,21,31H,13-16,27H2,(H3,28,29)(H,30,33)/t21-/m1/s1
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n/an/a 1.52E+3n/an/an/an/an/an/a



Universit£ Montpellier 1

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a by spectrometry


Bioorg Med Chem Lett 19: 1386-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.039
BindingDB Entry DOI: 10.7270/Q2G73DRB
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50293390
PNG
(2-[(3S)-8-Amino-3-[benzylsulfonylamino]-4-oxo-3,4-...)
Show SMILES NC(=N)c1ccc(CNC(=O)CN2c3ccc(N)cc3SC[C@@H](NS(=O)(=O)Cc3ccccc3)C2=O)cc1 |r|
Show InChI InChI=1S/C26H28N6O4S2/c27-20-10-11-22-23(12-20)37-15-21(31-38(35,36)16-18-4-2-1-3-5-18)26(34)32(22)14-24(33)30-13-17-6-8-19(9-7-17)25(28)29/h1-12,21,31H,13-16,27H2,(H3,28,29)(H,30,33)/t21-/m1/s1
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n/an/a 1.63E+3n/an/an/an/an/an/a



Universit£ Montpellier 1

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a by spectrometry


Bioorg Med Chem Lett 19: 1386-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.039
BindingDB Entry DOI: 10.7270/Q2G73DRB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50256009
PNG
(4-[2-(2-Hydroxy-ethylamino)-5-oxo-3,5-dihydro-imid...)
Show SMILES OCCNC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3ccsc3c12 |w:6.5,t:4|
Show InChI InChI=1S/C15H15N5O3S/c21-5-4-17-15-19-10(14(23)20-15)7-1-3-16-13(22)11-9(7)12-8(18-11)2-6-24-12/h2,6,18,21H,1,3-5H2,(H,16,22)(H2,17,19,20,23)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (Human))
BDBM50193232
PNG
(CHEMBL448732 | {(R)-1-[6-(4-carbamimidoyl-benzylca...)
Show SMILES CC(C)[C@@H](NCC(O)=O)C(=O)NC1(Cc2ccncc2C1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C24H30N6O4/c1-14(2)20(28-13-19(31)32)22(33)30-24(9-17-7-8-27-12-18(17)10-24)23(34)29-11-15-3-5-16(6-4-15)21(25)26/h3-8,12,14,20,28H,9-11,13H2,1-2H3,(H3,25,26)(H,29,34)(H,30,33)(H,31,32)/t20-,24?/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of human aPC


J Med Chem 49: 5047-50 (2006)


Article DOI: 10.1021/jm0606950
BindingDB Entry DOI: 10.7270/Q2H994VN
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50293388
PNG
(2-[(3S)-7-Aminomethyl-3-[benzylsulfonylamino]-4-ox...)
Show SMILES NCc1ccc2SC[C@@H](NS(=O)(=O)Cc3ccccc3)C(=O)N(CC(=O)NCc3ccc(cc3)C(N)=N)c2c1 |r|
Show InChI InChI=1S/C27H30N6O4S2/c28-13-20-8-11-24-23(12-20)33(15-25(34)31-14-18-6-9-21(10-7-18)26(29)30)27(35)22(16-38-24)32-39(36,37)17-19-4-2-1-3-5-19/h1-12,22,32H,13-17,28H2,(H3,29,30)(H,31,34)/t22-/m1/s1
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n/an/a 1.72E+3n/an/an/an/an/an/a



Universit£ Montpellier 1

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a by spectrometry


Bioorg Med Chem Lett 19: 1386-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.039
BindingDB Entry DOI: 10.7270/Q2G73DRB
More data for this
Ligand-Target Pair
Coagulation factor VII/tissue factor


(Homo sapiens (Human))
BDBM50293388
PNG
(2-[(3S)-7-Aminomethyl-3-[benzylsulfonylamino]-4-ox...)
Show SMILES NCc1ccc2SC[C@@H](NS(=O)(=O)Cc3ccccc3)C(=O)N(CC(=O)NCc3ccc(cc3)C(N)=N)c2c1 |r|
Show InChI InChI=1S/C27H30N6O4S2/c28-13-20-8-11-24-23(12-20)33(15-25(34)31-14-18-6-9-21(10-7-18)26(29)30)27(35)22(16-38-24)32-39(36,37)17-19-4-2-1-3-5-19/h1-12,22,32H,13-17,28H2,(H3,29,30)(H,31,34)/t22-/m1/s1
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n/an/a 1.86E+3n/an/an/an/an/an/a



Universit£ Montpellier 1

Curated by ChEMBL


Assay Description
Inhibition of human tissue factor/factor 7a


Bioorg Med Chem Lett 19: 1386-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.039
BindingDB Entry DOI: 10.7270/Q2G73DRB
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM50293391
PNG
(2-[(3S)-7-Amino-3-[benzylsulfonylamino]-4-oxo-3,4-...)
Show SMILES NC(=N)c1ccc(CNC(=O)CN2c3cc(N)ccc3SC[C@@H](NS(=O)(=O)Cc3ccccc3)C2=O)cc1 |r|
Show InChI InChI=1S/C26H28N6O4S2/c27-20-10-11-23-22(12-20)32(14-24(33)30-13-17-6-8-19(9-7-17)25(28)29)26(34)21(15-37-23)31-38(35,36)16-18-4-2-1-3-5-18/h1-12,21,31H,13-16,27H2,(H3,28,29)(H,30,33)/t21-/m1/s1
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n/an/a 1.89E+3n/an/an/an/an/an/a



Universit£ Montpellier 1

Curated by ChEMBL


Assay Description
Inhibition of human factor 2a by spectrophotometry


Bioorg Med Chem Lett 19: 1386-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.039
BindingDB Entry DOI: 10.7270/Q2G73DRB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM7491
PNG
((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)
Show SMILES NC1=NC(=O)C(N1)=C1CCNC(=O)c2[nH]c(Br)cc12 |w:7.19,t:1|
Show InChI InChI=1S/C11H10BrN5O2/c12-6-3-5-4(7-10(19)17-11(13)16-7)1-2-14-9(18)8(5)15-6/h3,15H,1-2H2,(H,14,18)(H3,13,16,17,19)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 19: 841-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.001
BindingDB Entry DOI: 10.7270/Q2QN66MH
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50293386
PNG
(CHEMBL554824 | {(3S)-5-[2-({4-[Amino(imino)methyl]...)
Show SMILES NC(=N)c1ccc(CNC(=O)CN2c3cc(CCC(O)=O)ccc3SC[C@@H](NS(=O)(=O)Cc3ccccc3)C2=O)cc1 |r|
Show InChI InChI=1S/C29H31N5O6S2/c30-28(31)22-10-6-20(7-11-22)15-32-26(35)16-34-24-14-19(9-13-27(36)37)8-12-25(24)41-17-23(29(34)38)33-42(39,40)18-21-4-2-1-3-5-21/h1-8,10-12,14,23,33H,9,13,15-18H2,(H3,30,31)(H,32,35)(H,36,37)/t23-/m1/s1
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n/an/a 2.03E+3n/an/an/an/an/an/a



Universit£ Montpellier 1

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a by spectrometry


Bioorg Med Chem Lett 19: 1386-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.039
BindingDB Entry DOI: 10.7270/Q2G73DRB
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (Human))
BDBM50193222
PNG
(2-{[(1R)-1-[(2-{[(4-carbamimidoylphenyl)methyl]car...)
Show SMILES CC[C@@H](NCC(O)=O)C(=O)NC1(Cc2ccccc2C1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C24H29N5O4/c1-2-19(27-14-20(30)31)22(32)29-24(11-17-5-3-4-6-18(17)12-24)23(33)28-13-15-7-9-16(10-8-15)21(25)26/h3-10,19,27H,2,11-14H2,1H3,(H3,25,26)(H,28,33)(H,29,32)(H,30,31)/t19-/m1/s1
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n/an/a 2.04E+3n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of human aPC


J Med Chem 49: 5047-50 (2006)


Article DOI: 10.1021/jm0606950
BindingDB Entry DOI: 10.7270/Q2H994VN
More data for this
Ligand-Target Pair
Coagulation factor VII/tissue factor


(Homo sapiens (Human))
BDBM50293391
PNG
(2-[(3S)-7-Amino-3-[benzylsulfonylamino]-4-oxo-3,4-...)
Show SMILES NC(=N)c1ccc(CNC(=O)CN2c3cc(N)ccc3SC[C@@H](NS(=O)(=O)Cc3ccccc3)C2=O)cc1 |r|
Show InChI InChI=1S/C26H28N6O4S2/c27-20-10-11-23-22(12-20)32(14-24(33)30-13-17-6-8-19(9-7-17)25(28)29)26(34)21(15-37-23)31-38(35,36)16-18-4-2-1-3-5-18/h1-12,21,31H,13-16,27H2,(H3,28,29)(H,30,33)/t21-/m1/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



Universit£ Montpellier 1

Curated by ChEMBL


Assay Description
Inhibition of human tissue factor/factor 7a


Bioorg Med Chem Lett 19: 1386-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.039
BindingDB Entry DOI: 10.7270/Q2G73DRB
More data for this
Ligand-Target Pair
Coagulation factor VII/tissue factor


(Homo sapiens (Human))
BDBM50293386
PNG
(CHEMBL554824 | {(3S)-5-[2-({4-[Amino(imino)methyl]...)
Show SMILES NC(=N)c1ccc(CNC(=O)CN2c3cc(CCC(O)=O)ccc3SC[C@@H](NS(=O)(=O)Cc3ccccc3)C2=O)cc1 |r|
Show InChI InChI=1S/C29H31N5O6S2/c30-28(31)22-10-6-20(7-11-22)15-32-26(35)16-34-24-14-19(9-13-27(36)37)8-12-25(24)41-17-23(29(34)38)33-42(39,40)18-21-4-2-1-3-5-21/h1-8,10-12,14,23,33H,9,13,15-18H2,(H3,30,31)(H,32,35)(H,36,37)/t23-/m1/s1
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n/an/a 2.64E+3n/an/an/an/an/an/a



Universit£ Montpellier 1

Curated by ChEMBL


Assay Description
Inhibition of human tissue factor/factor 7a


Bioorg Med Chem Lett 19: 1386-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.039
BindingDB Entry DOI: 10.7270/Q2G73DRB
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50293385
PNG
(2-[(3S)-7-[2-Aminoethyl]-3-[benzylsulfonylamino]-4...)
Show SMILES NCCc1ccc2SC[C@@H](NS(=O)(=O)Cc3ccccc3)C(=O)N(CC(=O)NCc3ccc(cc3)C(N)=N)c2c1 |r|
Show InChI InChI=1S/C28H32N6O4S2/c29-13-12-19-8-11-25-24(14-19)34(16-26(35)32-15-20-6-9-22(10-7-20)27(30)31)28(36)23(17-39-25)33-40(37,38)18-21-4-2-1-3-5-21/h1-11,14,23,33H,12-13,15-18,29H2,(H3,30,31)(H,32,35)/t23-/m1/s1
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n/an/a 2.79E+3n/an/an/an/an/an/a



Universit£ Montpellier 1

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a by spectrometry


Bioorg Med Chem Lett 19: 1386-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.039
BindingDB Entry DOI: 10.7270/Q2G73DRB
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50293383
PNG
(2-[(3S)-3-[Benzylsulfonylamino]-7-(3-nitrophenyl)-...)
Show SMILES NC(=N)c1ccc(CNC(=O)CN2c3cc(ccc3SC[C@@H](NS(=O)(=O)Cc3ccccc3)C2=O)-c2cccc(c2)[N+]([O-])=O)cc1 |r|
Show InChI InChI=1S/C32H30N6O6S2/c33-31(34)23-11-9-21(10-12-23)17-35-30(39)18-37-28-16-25(24-7-4-8-26(15-24)38(41)42)13-14-29(28)45-19-27(32(37)40)36-46(43,44)20-22-5-2-1-3-6-22/h1-16,27,36H,17-20H2,(H3,33,34)(H,35,39)/t27-/m1/s1
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n/an/a 2.81E+3n/an/an/an/an/an/a



Universit£ Montpellier 1

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a by spectrometry


Bioorg Med Chem Lett 19: 1386-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.039
BindingDB Entry DOI: 10.7270/Q2G73DRB
More data for this
Ligand-Target Pair
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