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Compile Data Set for Download or QSAR

Found 114 hits with Last Name = 'gonzalez' and Initial = 'w'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neprilysin


(Homo sapiens (Human))
BDBM50407297
PNG
(CHEMBL2052008)
Show SMILES C[C@H](NC(=O)[C@H](CS)[C@@H](C)c1ccccc1)C(O)=O |r|
Show InChI InChI=1S/C14H19NO3S/c1-9(11-6-4-3-5-7-11)12(8-19)13(16)15-10(2)14(17)18/h3-7,9-10,12,19H,8H2,1-2H3,(H,15,16)(H,17,18)/t9-,10-,12+/m0/s1
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2.10n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50407297
PNG
(CHEMBL2052008)
Show SMILES C[C@H](NC(=O)[C@H](CS)[C@@H](C)c1ccccc1)C(O)=O |r|
Show InChI InChI=1S/C14H19NO3S/c1-9(11-6-4-3-5-7-11)12(8-19)13(16)15-10(2)14(17)18/h3-7,9-10,12,19H,8H2,1-2H3,(H,15,16)(H,17,18)/t9-,10-,12+/m0/s1
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INSERM

Curated by ChEMBL


Assay Description
In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50407299
PNG
(CHEMBL2052007)
Show SMILES C[C@H]([C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(O)=O)c1ccccc1 |r|
Show InChI InChI=1S/C20H23NO3S/c1-14(16-10-6-3-7-11-16)17(13-25)19(22)21-18(20(23)24)12-15-8-4-2-5-9-15/h2-11,14,17-18,25H,12-13H2,1H3,(H,21,22)(H,23,24)/t14-,17+,18-/m0/s1
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INSERM

Curated by ChEMBL


Assay Description
In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50407299
PNG
(CHEMBL2052007)
Show SMILES C[C@H]([C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(O)=O)c1ccccc1 |r|
Show InChI InChI=1S/C20H23NO3S/c1-14(16-10-6-3-7-11-16)17(13-25)19(22)21-18(20(23)24)12-15-8-4-2-5-9-15/h2-11,14,17-18,25H,12-13H2,1H3,(H,21,22)(H,23,24)/t14-,17+,18-/m0/s1
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INSERM

Curated by ChEMBL


Assay Description
In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Mus musculus)
BDBM50407297
PNG
(CHEMBL2052008)
Show SMILES C[C@H](NC(=O)[C@H](CS)[C@@H](C)c1ccccc1)C(O)=O |r|
Show InChI InChI=1S/C14H19NO3S/c1-9(11-6-4-3-5-7-11)12(8-19)13(16)15-10(2)14(17)18/h3-7,9-10,12,19H,8H2,1-2H3,(H,15,16)(H,17,18)/t9-,10-,12+/m0/s1
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4.5n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory potency against angiotensin converting enzyme by displacement of [3H]-trandolaprilate binding in mouse lung


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50407298
PNG
(CHEMBL2051772)
Show SMILES C[C@@H]([C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(O)=O)c1ccccc1 |r|
Show InChI InChI=1S/C20H23NO3S/c1-14(16-10-6-3-7-11-16)17(13-25)19(22)21-18(20(23)24)12-15-8-4-2-5-9-15/h2-11,14,17-18,25H,12-13H2,1H3,(H,21,22)(H,23,24)/t14-,17-,18+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Mus musculus)
BDBM50407298
PNG
(CHEMBL2051772)
Show SMILES C[C@@H]([C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(O)=O)c1ccccc1 |r|
Show InChI InChI=1S/C20H23NO3S/c1-14(16-10-6-3-7-11-16)17(13-25)19(22)21-18(20(23)24)12-15-8-4-2-5-9-15/h2-11,14,17-18,25H,12-13H2,1H3,(H,21,22)(H,23,24)/t14-,17-,18+/m1/s1
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10n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory potency against angiotensin converting enzyme by displacement of [3H]-trandolaprilate binding in mouse lung


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Mus musculus)
BDBM50407297
PNG
(CHEMBL2052008)
Show SMILES C[C@H](NC(=O)[C@H](CS)[C@@H](C)c1ccccc1)C(O)=O |r|
Show InChI InChI=1S/C14H19NO3S/c1-9(11-6-4-3-5-7-11)12(8-19)13(16)15-10(2)14(17)18/h3-7,9-10,12,19H,8H2,1-2H3,(H,15,16)(H,17,18)/t9-,10-,12+/m0/s1
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16n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory potency against angiotensin converting enzyme by displacement of [3H]-trandolaprilate binding in mouse lung


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Mus musculus)
BDBM50407299
PNG
(CHEMBL2052007)
Show SMILES C[C@H]([C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(O)=O)c1ccccc1 |r|
Show InChI InChI=1S/C20H23NO3S/c1-14(16-10-6-3-7-11-16)17(13-25)19(22)21-18(20(23)24)12-15-8-4-2-5-9-15/h2-11,14,17-18,25H,12-13H2,1H3,(H,21,22)(H,23,24)/t14-,17+,18-/m0/s1
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26n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory potency against angiotensin converting enzyme by displacement of [3H]-trandolaprilate binding in mouse lung


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Mus musculus)
BDBM50407299
PNG
(CHEMBL2052007)
Show SMILES C[C@H]([C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(O)=O)c1ccccc1 |r|
Show InChI InChI=1S/C20H23NO3S/c1-14(16-10-6-3-7-11-16)17(13-25)19(22)21-18(20(23)24)12-15-8-4-2-5-9-15/h2-11,14,17-18,25H,12-13H2,1H3,(H,21,22)(H,23,24)/t14-,17+,18-/m0/s1
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26n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory potency against angiotensin converting enzyme by displacement of [3H]-trandolaprilate binding in mouse lung


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50051796
PNG
((2S,5R)-5-(2-Hydroxy-phenyl)-1-{2-[(S)-2-mercapto-...)
Show SMILES COc1ccc(C[C@H](S)C(=O)NCC(=O)N2[C@@H](CC[C@@H]2c2ccccc2O)C(O)=O)cc1
Show InChI InChI=1S/C23H26N2O6S/c1-31-15-8-6-14(7-9-15)12-20(32)22(28)24-13-21(27)25-17(10-11-18(25)23(29)30)16-4-2-3-5-19(16)26/h2-9,17-18,20,26,32H,10-13H2,1H3,(H,24,28)(H,29,30)/t17-,18+,20+/m1/s1
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n/an/a 0.420n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of rat angiotensin I converting enzyme


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50051798
PNG
((2S,5R)-5-(4-Hydroxy-phenyl)-1-{2-[(S)-3-(4-hydrox...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccc(O)cc1)c1ccc(O)cc1
Show InChI InChI=1S/C22H24N2O6S/c25-15-5-1-13(2-6-15)11-19(31)21(28)23-12-20(27)24-17(9-10-18(24)22(29)30)14-3-7-16(26)8-4-14/h1-8,17-19,25-26,31H,9-12H2,(H,23,28)(H,29,30)/t17-,18+,19+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of rat angiotensin I converting enzyme


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50051784
PNG
((2S,5R)-5-(2-Hydroxy-phenyl)-1-[2-((S)-2-mercapto-...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccccc1)c1ccccc1O
Show InChI InChI=1S/C22H24N2O5S/c25-18-9-5-4-8-15(18)16-10-11-17(22(28)29)24(16)20(26)13-23-21(27)19(30)12-14-6-2-1-3-7-14/h1-9,16-17,19,25,30H,10-13H2,(H,23,27)(H,28,29)/t16-,17+,19+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of rat angiotensin I converting enzyme


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50051785
PNG
((2S,5R)-1-[2-((S)-2-Mercapto-3-phenyl-propionylami...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H24N2O4S/c25-20(14-23-21(26)19(29)13-15-7-3-1-4-8-15)24-17(11-12-18(24)22(27)28)16-9-5-2-6-10-16/h1-10,17-19,29H,11-14H2,(H,23,26)(H,27,28)/t17-,18+,19+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of rat angiotensin I converting enzyme


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50051780
PNG
((2S,5R)-5-(2-Hydroxy-phenyl)-1-{2-[(S)-3-(4-hydrox...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccc(O)cc1)c1ccccc1O
Show InChI InChI=1S/C22H24N2O6S/c25-14-7-5-13(6-8-14)11-19(31)21(28)23-12-20(27)24-16(9-10-17(24)22(29)30)15-3-1-2-4-18(15)26/h1-8,16-17,19,25-26,31H,9-12H2,(H,23,28)(H,29,30)/t16-,17+,19+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of rat angiotensin I converting enzyme


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50051791
PNG
((2S,5R)-5-(3-Hydroxy-phenyl)-1-{2-[(S)-3-(4-hydrox...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccc(O)cc1)c1cccc(O)c1
Show InChI InChI=1S/C22H24N2O6S/c25-15-6-4-13(5-7-15)10-19(31)21(28)23-12-20(27)24-17(8-9-18(24)22(29)30)14-2-1-3-16(26)11-14/h1-7,11,17-19,25-26,31H,8-10,12H2,(H,23,28)(H,29,30)/t17-,18+,19+/m1/s1
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n/an/a 0.700n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of rat angiotensin I converting enzyme


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50051803
PNG
((2S,5R)-1-{2-[3-(4-Chloro-phenyl)-2-mercapto-propi...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)C(S)Cc1ccc(Cl)cc1)c1ccccc1O
Show InChI InChI=1S/C22H23ClN2O5S/c23-14-7-5-13(6-8-14)11-19(31)21(28)24-12-20(27)25-16(9-10-17(25)22(29)30)15-3-1-2-4-18(15)26/h1-8,16-17,19,26,31H,9-12H2,(H,24,28)(H,29,30)/t16-,17+,19?/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of rat angiotensin I converting enzyme


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50051784
PNG
((2S,5R)-5-(2-Hydroxy-phenyl)-1-[2-((S)-2-mercapto-...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccccc1)c1ccccc1O
Show InChI InChI=1S/C22H24N2O5S/c25-18-9-5-4-8-15(18)16-10-11-17(22(28)29)24(16)20(26)13-23-21(27)19(30)12-14-6-2-1-3-7-14/h1-9,16-17,19,25,30H,10-13H2,(H,23,27)(H,28,29)/t16-,17+,19+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50051803
PNG
((2S,5R)-1-{2-[3-(4-Chloro-phenyl)-2-mercapto-propi...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)C(S)Cc1ccc(Cl)cc1)c1ccccc1O
Show InChI InChI=1S/C22H23ClN2O5S/c23-14-7-5-13(6-8-14)11-19(31)21(28)24-12-20(27)25-16(9-10-17(25)22(29)30)15-3-1-2-4-18(15)26/h1-8,16-17,19,26,31H,9-12H2,(H,24,28)(H,29,30)/t16-,17+,19?/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50041071
PNG
((2-Mercaptomethyl-3-phenyl-butyrylamino)-acetic ac...)
Show SMILES CC(C(CS)C(=O)NCC(O)=O)c1ccccc1
Show InChI InChI=1S/C13H17NO3S/c1-9(10-5-3-2-4-6-10)11(8-18)13(17)14-7-12(15)16/h2-6,9,11,18H,7-8H2,1H3,(H,14,17)(H,15,16)
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INSERM

Curated by ChEMBL


Assay Description
In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50051790
PNG
((2S,5R)-5-(3-Hydroxy-phenyl)-1-[2-((S)-2-mercapto-...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccccc1)c1cccc(O)c1
Show InChI InChI=1S/C22H24N2O5S/c25-16-8-4-7-15(12-16)17-9-10-18(22(28)29)24(17)20(26)13-23-21(27)19(30)11-14-5-2-1-3-6-14/h1-8,12,17-19,25,30H,9-11,13H2,(H,23,27)(H,28,29)/t17-,18+,19+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of rat angiotensin I converting enzyme


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50051800
PNG
(1-{2-[(S)-3-(4-Hydroxy-phenyl)-2-mercapto-propiony...)
Show SMILES Cc1cccc(c1)C1CCC(N1C(=O)CNC(=O)[C@@H](S)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C23H26N2O5S/c1-14-3-2-4-16(11-14)18-9-10-19(23(29)30)25(18)21(27)13-24-22(28)20(31)12-15-5-7-17(26)8-6-15/h2-8,11,18-20,26,31H,9-10,12-13H2,1H3,(H,24,28)(H,29,30)/t18?,19?,20-/m0/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50051791
PNG
((2S,5R)-5-(3-Hydroxy-phenyl)-1-{2-[(S)-3-(4-hydrox...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccc(O)cc1)c1cccc(O)c1
Show InChI InChI=1S/C22H24N2O6S/c25-15-6-4-13(5-7-15)10-19(31)21(28)23-12-20(27)24-17(8-9-18(24)22(29)30)14-2-1-3-16(26)11-14/h1-7,11,17-19,25-26,31H,8-10,12H2,(H,23,28)(H,29,30)/t17-,18+,19+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50051785
PNG
((2S,5R)-1-[2-((S)-2-Mercapto-3-phenyl-propionylami...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H24N2O4S/c25-20(14-23-21(26)19(29)13-15-7-3-1-4-8-15)24-17(11-12-18(24)22(27)28)16-9-5-2-6-10-16/h1-10,17-19,29H,11-14H2,(H,23,26)(H,27,28)/t17-,18+,19+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50051794
PNG
((2S,5R)-1-{2-[(S)-3-(4-Amino-phenyl)-2-mercapto-pr...)
Show SMILES Nc1ccc(C[C@H](S)C(=O)NCC(=O)N2[C@@H](CC[C@@H]2c2ccccc2)C(O)=O)cc1
Show InChI InChI=1S/C22H25N3O4S/c23-16-8-6-14(7-9-16)12-19(30)21(27)24-13-20(26)25-17(10-11-18(25)22(28)29)15-4-2-1-3-5-15/h1-9,17-19,30H,10-13,23H2,(H,24,27)(H,28,29)/t17-,18+,19+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50041069
PNG
(3-(4-Hydroxy-phenyl)-2-(2-mercaptomethyl-3-phenyl-...)
Show SMILES OC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CS)Cc1ccccc1
Show InChI InChI=1S/C19H21NO4S/c21-16-8-6-14(7-9-16)11-17(19(23)24)20-18(22)15(12-25)10-13-4-2-1-3-5-13/h1-9,15,17,21,25H,10-12H2,(H,20,22)(H,23,24)
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INSERM

Curated by ChEMBL


Assay Description
In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50041067
PNG
(2-[3-(4-Fluoro-phenyl)-2-mercaptomethyl-butyrylami...)
Show SMILES CC(NC(=O)C(CS)C(C)c1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C14H18FNO3S/c1-8(10-3-5-11(15)6-4-10)12(7-20)13(17)16-9(2)14(18)19/h3-6,8-9,12,20H,7H2,1-2H3,(H,16,17)(H,18,19)
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INSERM

Curated by ChEMBL


Assay Description
In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50041058
PNG
(2-(3-Benzo[1,3]dioxol-5-yl-2-mercaptomethyl-butyry...)
Show SMILES CC(NC(=O)C(CS)C(C)c1ccc2OCOc2c1)C(O)=O
Show InChI InChI=1S/C15H19NO5S/c1-8(10-3-4-12-13(5-10)21-7-20-12)11(6-22)14(17)16-9(2)15(18)19/h3-5,8-9,11,22H,6-7H2,1-2H3,(H,16,17)(H,18,19)
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INSERM

Curated by ChEMBL


Assay Description
In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50407297
PNG
(CHEMBL2052008)
Show SMILES C[C@H](NC(=O)[C@H](CS)[C@@H](C)c1ccccc1)C(O)=O |r|
Show InChI InChI=1S/C14H19NO3S/c1-9(11-6-4-3-5-7-11)12(8-19)13(16)15-10(2)14(17)18/h3-7,9-10,12,19H,8H2,1-2H3,(H,15,16)(H,17,18)/t9-,10-,12+/m0/s1
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INSERM

Curated by ChEMBL


Assay Description
In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50051799
PNG
((2S,5R)-1-{2-[(S)-2-Mercapto-3-(4-methoxy-phenyl)-...)
Show SMILES COc1ccc(C[C@H](S)C(=O)NCC(=O)N2[C@@H](CC[C@@H]2c2ccccc2OC)C(O)=O)cc1
Show InChI InChI=1S/C24H28N2O6S/c1-31-16-9-7-15(8-10-16)13-21(33)23(28)25-14-22(27)26-18(11-12-19(26)24(29)30)17-5-3-4-6-20(17)32-2/h3-10,18-19,21,33H,11-14H2,1-2H3,(H,25,28)(H,29,30)/t18-,19+,21+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of rat angiotensin I converting enzyme


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50051796
PNG
((2S,5R)-5-(2-Hydroxy-phenyl)-1-{2-[(S)-2-mercapto-...)
Show SMILES COc1ccc(C[C@H](S)C(=O)NCC(=O)N2[C@@H](CC[C@@H]2c2ccccc2O)C(O)=O)cc1
Show InChI InChI=1S/C23H26N2O6S/c1-31-15-8-6-14(7-9-15)12-20(32)22(28)24-13-21(27)25-17(10-11-18(25)23(29)30)16-4-2-3-5-19(16)26/h2-9,17-18,20,26,32H,10-13H2,1H3,(H,24,28)(H,29,30)/t17-,18+,20+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50051804
PNG
((2S,5R)-1-[2-((S)-2-Mercapto-3-phenyl-propionylami...)
Show SMILES Cc1cccc(c1)[C@H]1CC[C@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C23H26N2O4S/c1-15-6-5-9-17(12-15)18-10-11-19(23(28)29)25(18)21(26)14-24-22(27)20(30)13-16-7-3-2-4-8-16/h2-9,12,18-20,30H,10-11,13-14H2,1H3,(H,24,27)(H,28,29)/t18-,19+,20+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50041070
PNG
(3-(4-Hydroxy-phenyl)-2-(2-mercaptomethyl-3-phenyl-...)
Show SMILES CCC(C(CS)C(=O)NC(Cc1ccc(O)cc1)C(O)=O)c1ccccc1
Show InChI InChI=1S/C21H25NO4S/c1-2-17(15-6-4-3-5-7-15)18(13-27)20(24)22-19(21(25)26)12-14-8-10-16(23)11-9-14/h3-11,17-19,23,27H,2,12-13H2,1H3,(H,22,24)(H,25,26)
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INSERM

Curated by ChEMBL


Assay Description
In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50051790
PNG
((2S,5R)-5-(3-Hydroxy-phenyl)-1-[2-((S)-2-mercapto-...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccccc1)c1cccc(O)c1
Show InChI InChI=1S/C22H24N2O5S/c25-16-8-4-7-15(12-16)17-9-10-18(22(28)29)24(17)20(26)13-23-21(27)19(30)11-14-5-2-1-3-6-14/h1-8,12,17-19,25,30H,9-11,13H2,(H,23,27)(H,28,29)/t17-,18+,19+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50051786
PNG
((2S,5R)-1-{2-[(S)-3-(4-Hydroxy-phenyl)-2-mercapto-...)
Show SMILES Cc1ccc(cc1)[C@H]1CC[C@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C23H26N2O5S/c1-14-2-6-16(7-3-14)18-10-11-19(23(29)30)25(18)21(27)13-24-22(28)20(31)12-15-4-8-17(26)9-5-15/h2-9,18-20,26,31H,10-13H2,1H3,(H,24,28)(H,29,30)/t18-,19+,20+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of rat angiotensin I converting enzyme


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50041054
PNG
(3-(4-Hydroxy-phenyl)-2-(2-mercaptomethyl-3-phenyl-...)
Show SMILES CC(C(CS)C(=O)NC(Cc1ccc(O)cc1)C(O)=O)c1ccccc1
Show InChI InChI=1S/C20H23NO4S/c1-13(15-5-3-2-4-6-15)17(12-26)19(23)21-18(20(24)25)11-14-7-9-16(22)10-8-14/h2-10,13,17-18,22,26H,11-12H2,1H3,(H,21,23)(H,24,25)
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INSERM

Curated by ChEMBL


Assay Description
In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Neprilysin


(Mus musculus)
BDBM50041062
PNG
(3-(4-Hydroxy-phenyl)-2-[2-mercaptomethyl-3-(4-meth...)
Show SMILES COc1ccc(cc1)C(C)C(CS)C(=O)NC(Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C21H25NO5S/c1-13(15-5-9-17(27-2)10-6-15)18(12-28)20(24)22-19(21(25)26)11-14-3-7-16(23)8-4-14/h3-10,13,18-19,23,28H,11-12H2,1-2H3,(H,22,24)(H,25,26)
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INSERM

Curated by ChEMBL


Assay Description
In vivo inhibitory potency against Neutral Endopeptidase by measuring the displacement of [3H]-HACBOGly binding in mouse kidney


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50051799
PNG
((2S,5R)-1-{2-[(S)-2-Mercapto-3-(4-methoxy-phenyl)-...)
Show SMILES COc1ccc(C[C@H](S)C(=O)NCC(=O)N2[C@@H](CC[C@@H]2c2ccccc2OC)C(O)=O)cc1
Show InChI InChI=1S/C24H28N2O6S/c1-31-16-9-7-15(8-10-16)13-21(33)23(28)25-14-22(27)26-18(11-12-19(26)24(29)30)17-5-3-4-6-20(17)32-2/h3-10,18-19,21,33H,11-14H2,1-2H3,(H,25,28)(H,29,30)/t18-,19+,21+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50407847
PNG
(CHEMBL2115220)
Show SMILES Cc1ccccc1[C@H]1CC[C@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C23H26N2O5S/c1-14-4-2-3-5-17(14)18-10-11-19(23(29)30)25(18)21(27)13-24-22(28)20(31)12-15-6-8-16(26)9-7-15/h2-9,18-20,26,31H,10-13H2,1H3,(H,24,28)(H,29,30)/t18-,19+,20+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50051800
PNG
(1-{2-[(S)-3-(4-Hydroxy-phenyl)-2-mercapto-propiony...)
Show SMILES Cc1cccc(c1)C1CCC(N1C(=O)CNC(=O)[C@@H](S)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C23H26N2O5S/c1-14-3-2-4-16(11-14)18-9-10-19(23(29)30)25(18)21(27)13-24-22(28)20(31)12-15-5-7-17(26)8-6-15/h2-8,11,18-20,26,31H,9-10,12-13H2,1H3,(H,24,28)(H,29,30)/t18?,19?,20-/m0/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of rat angiotensin I converting enzyme


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50051778
PNG
((2S,5R)-1-[2-((S)-2-Mercapto-3-phenyl-propionylami...)
Show SMILES Cc1ccccc1[C@H]1CC[C@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C23H26N2O4S/c1-15-7-5-6-10-17(15)18-11-12-19(23(28)29)25(18)21(26)14-24-22(27)20(30)13-16-8-3-2-4-9-16/h2-10,18-20,30H,11-14H2,1H3,(H,24,27)(H,28,29)/t18-,19+,20+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of rat angiotensin I converting enzyme


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50041061
PNG
(2-(2-Mercaptomethyl-3-phenyl-butyrylamino)-hexanoi...)
Show SMILES CCCCC(NC(=O)C(CS)C(C)c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H25NO3S/c1-3-4-10-15(17(20)21)18-16(19)14(11-22)12(2)13-8-6-5-7-9-13/h5-9,12,14-15,22H,3-4,10-11H2,1-2H3,(H,18,19)(H,20,21)
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INSERM

Curated by ChEMBL


Assay Description
In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50051805
PNG
((2S,5R)-1-[2-((R)-2-Mercapto-3-phenyl-propionylami...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)[C@H](S)Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H24N2O4S/c25-20(14-23-21(26)19(29)13-15-7-3-1-4-8-15)24-17(11-12-18(24)22(27)28)16-9-5-2-6-10-16/h1-10,17-19,29H,11-14H2,(H,23,26)(H,27,28)/t17-,18+,19-/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50051795
PNG
((2S,5R)-5-(3-Hydroxy-phenyl)-1-{2-[(S)-3-(3-hydrox...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)[C@@H](S)Cc1cccc(O)c1)c1cccc(O)c1
Show InChI InChI=1S/C22H24N2O6S/c25-15-5-1-3-13(9-15)10-19(31)21(28)23-12-20(27)24-17(7-8-18(24)22(29)30)14-4-2-6-16(26)11-14/h1-6,9,11,17-19,25-26,31H,7-8,10,12H2,(H,23,28)(H,29,30)/t17-,18+,19+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of rat angiotensin I converting enzyme


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50051787
PNG
((2S,5R)-1-{2-[(S)-3-(4-Hydroxy-phenyl)-2-mercapto-...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccc(O)cc1)c1ccccc1
Show InChI InChI=1S/C22H24N2O5S/c25-16-8-6-14(7-9-16)12-19(30)21(27)23-13-20(26)24-17(10-11-18(24)22(28)29)15-4-2-1-3-5-15/h1-9,17-19,25,30H,10-13H2,(H,23,27)(H,28,29)/t17-,18+,19+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50051789
PNG
((2S,5R)-1-{2-[(S)-3-(4-Hydroxy-phenyl)-2-mercapto-...)
Show SMILES COc1ccccc1[C@H]1CC[C@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C23H26N2O6S/c1-31-19-5-3-2-4-16(19)17-10-11-18(23(29)30)25(17)21(27)13-24-22(28)20(32)12-14-6-8-15(26)9-7-14/h2-9,17-18,20,26,32H,10-13H2,1H3,(H,24,28)(H,29,30)/t17-,18+,20+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50041059
PNG
(2-(2-Mercaptomethyl-3-phenyl-butyrylamino)-4-methy...)
Show SMILES CC(C)CC(NC(=O)C(CS)C(C)c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H25NO3S/c1-11(2)9-15(17(20)21)18-16(19)14(10-22)12(3)13-7-5-4-6-8-13/h4-8,11-12,14-15,22H,9-10H2,1-3H3,(H,18,19)(H,20,21)
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INSERM

Curated by ChEMBL


Assay Description
In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50041053
PNG
(2-[3-(3,4-Difluoro-phenyl)-2-mercaptomethyl-butyry...)
Show SMILES CC(NC(=O)C(CS)C(C)c1ccc(F)c(F)c1)C(O)=O
Show InChI InChI=1S/C14H17F2NO3S/c1-7(9-3-4-11(15)12(16)5-9)10(6-21)13(18)17-8(2)14(19)20/h3-5,7-8,10,21H,6H2,1-2H3,(H,17,18)(H,19,20)
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INSERM

Curated by ChEMBL


Assay Description
In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney


J Med Chem 37: 1070-83 (1994)


BindingDB Entry DOI: 10.7270/Q26W995T
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50051780
PNG
((2S,5R)-5-(2-Hydroxy-phenyl)-1-{2-[(S)-3-(4-hydrox...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccc(O)cc1)c1ccccc1O
Show InChI InChI=1S/C22H24N2O6S/c25-14-7-5-13(6-8-14)11-19(31)21(28)23-12-20(27)24-16(9-10-17(24)22(29)30)15-3-1-2-4-18(15)26/h1-8,16-17,19,25-26,31H,9-12H2,(H,23,28)(H,29,30)/t16-,17+,19+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)
BDBM50051794
PNG
((2S,5R)-1-{2-[(S)-3-(4-Amino-phenyl)-2-mercapto-pr...)
Show SMILES Nc1ccc(C[C@H](S)C(=O)NCC(=O)N2[C@@H](CC[C@@H]2c2ccccc2)C(O)=O)cc1
Show InChI InChI=1S/C22H25N3O4S/c23-16-8-6-14(7-9-16)12-19(30)21(27)24-13-20(26)25-17(10-11-18(25)22(28)29)15-4-2-1-3-5-15/h1-9,17-19,30H,10-13,23H2,(H,24,27)(H,28,29)/t17-,18+,19+/m1/s1
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INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of rat angiotensin I converting enzyme


J Med Chem 39: 2594-608 (1996)


Article DOI: 10.1021/jm950783c
BindingDB Entry DOI: 10.7270/Q25B0353
More data for this
Ligand-Target Pair
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