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Compile Data Set for Download or QSAR

Found 421 hits with Last Name = 'gough' and Initial = 'pj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50159507
PNG
(CHEMBL3785703)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O |r|
Show InChI InChI=1/C21H19N3O4/c1-24-18-9-5-6-10-19(18)27-13-17(21(24)26)22-20(25)16-12-15(28-23-16)11-14-7-3-2-4-8-14/h2-10,12,17H,11,13H2,1H3,(H,22,25)/t17-/s2
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0.800n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Competitive inhibition of human RIP1 (1 to 375 residues) in presence of increasing ATP by ADP-Glo reagent based assay


J Med Chem 59: 2163-78 (2016)


BindingDB Entry DOI: 10.7270/Q26H4K97
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359016
PNG
(CHEMBL1924017)
Show SMILES FC(F)(F)c1cc(ccc1Cl)S(=O)(=O)Nc1cc(Cl)ccc1Oc1ccc(cc1)C(=O)NCCN1CCCC1
Show InChI InChI=1S/C26H24Cl2F3N3O4S/c27-18-5-10-24(23(15-18)33-39(36,37)20-8-9-22(28)21(16-20)26(29,30)31)38-19-6-3-17(4-7-19)25(35)32-11-14-34-12-1-2-13-34/h3-10,15-16,33H,1-2,11-14H2,(H,32,35)
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2n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359013
PNG
(CHEMBL1924014)
Show SMILES FC(F)(F)c1cc(ccc1Cl)S(=O)(=O)Nc1cc(Cl)cnc1Oc1ccc(cc1)C(=O)NCCN1CCCCC1
Show InChI InChI=1S/C26H25Cl2F3N4O4S/c27-18-14-23(34-40(37,38)20-8-9-22(28)21(15-20)26(29,30)31)25(33-16-18)39-19-6-4-17(5-7-19)24(36)32-10-13-35-11-2-1-3-12-35/h4-9,14-16,34H,1-3,10-13H2,(H,32,36)
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3n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359018
PNG
(CHEMBL1924019)
Show SMILES COc1cc(Oc2ccc(cc2)C(=O)NCCN2CCCC2)c(NS(=O)(=O)c2ccc(Cl)c(c2)C(F)(F)F)cc1Cl
Show InChI InChI=1S/C27H26Cl2F3N3O5S/c1-39-24-16-25(40-18-6-4-17(5-7-18)26(36)33-10-13-35-11-2-3-12-35)23(15-22(24)29)34-41(37,38)19-8-9-21(28)20(14-19)27(30,31)32/h4-9,14-16,34H,2-3,10-13H2,1H3,(H,33,36)
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4n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359032
PNG
(CHEMBL1924024)
Show SMILES COc1cc(ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(c1)C(F)(F)F)C(=O)NCCN1CCCC1
Show InChI InChI=1S/C27H26Cl2F3N3O5S/c1-39-25-14-17(26(36)33-10-13-35-11-2-3-12-35)4-8-24(25)40-23-9-5-18(28)15-22(23)34-41(37,38)19-6-7-21(29)20(16-19)27(30,31)32/h4-9,14-16,34H,2-3,10-13H2,1H3,(H,33,36)
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6n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359017
PNG
(CHEMBL1924018)
Show SMILES Cc1cc(Oc2ccc(cc2)C(=O)NCCN2CCCC2)c(NS(=O)(=O)c2ccc(Cl)c(c2)C(F)(F)F)cc1Cl
Show InChI InChI=1S/C27H26Cl2F3N3O4S/c1-17-14-25(39-19-6-4-18(5-7-19)26(36)33-10-13-35-11-2-3-12-35)24(16-23(17)29)34-40(37,38)20-8-9-22(28)21(15-20)27(30,31)32/h4-9,14-16,34H,2-3,10-13H2,1H3,(H,33,36)
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8n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359022
PNG
(CHEMBL1924023)
Show SMILES Cc1cc(ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(c1)C(F)(F)F)C(=O)NCCN1CCCC1
Show InChI InChI=1S/C27H26Cl2F3N3O4S/c1-17-14-18(26(36)33-10-13-35-11-2-3-12-35)4-8-24(17)39-25-9-5-19(28)15-23(25)34-40(37,38)20-6-7-22(29)21(16-20)27(30,31)32/h4-9,14-16,34H,2-3,10-13H2,1H3,(H,33,36)
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8n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401549
PNG
(CHEMBL2207081)
Show SMILES Clc1ccc(Cn2ccnn2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C15H11Cl3N4O2S/c16-11-2-1-10(9-22-6-5-19-21-22)15(7-11)20-25(23,24)12-3-4-13(17)14(18)8-12/h1-8,20H,9H2
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10n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401561
PNG
(CHEMBL2207082)
Show SMILES Clc1ccc(Cn2cnnc2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C15H11Cl3N4O2S/c16-11-2-1-10(7-22-8-19-20-9-22)15(5-11)21-25(23,24)12-3-4-13(17)14(18)6-12/h1-6,8-9,21H,7H2
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10n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401550
PNG
(CHEMBL2207084)
Show SMILES Cc1nnnn1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H12Cl3N5O2S/c1-9-19-21-22-23(9)8-10-2-3-11(16)6-15(10)20-26(24,25)12-4-5-13(17)14(18)7-12/h2-7,20H,8H2,1H3
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10n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401549
PNG
(CHEMBL2207081)
Show SMILES Clc1ccc(Cn2ccnn2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C15H11Cl3N4O2S/c16-11-2-1-10(9-22-6-5-19-21-22)15(7-11)20-25(23,24)12-3-4-13(17)14(18)8-12/h1-8,20H,9H2
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10n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to human CCR2


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401547
PNG
(CHEMBL2207098)
Show SMILES Clc1ccc(cc1Cl)S(=O)(=O)Nc1cc(Cl)c(Cl)cc1Cn1ccnn1
Show InChI InChI=1S/C15H10Cl4N4O2S/c16-11-2-1-10(6-13(11)18)26(24,25)21-15-7-14(19)12(17)5-9(15)8-23-4-3-20-22-23/h1-7,21H,8H2
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10n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359023
PNG
(CHEMBL1170725)
Show SMILES Cc1ncccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H12Cl3N3O3S/c1-10-16(3-2-6-21-10)26-17-15(7-11(18)9-22-17)23-27(24,25)12-4-5-13(19)14(20)8-12/h2-9,23H,1H3
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10n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359015
PNG
(CHEMBL1924016)
Show SMILES COc1cc(Oc2ccc(cc2)C(=O)NCCN2CCCCC2)c(NS(=O)(=O)c2ccc(Cl)c(c2)C(F)(F)F)cc1Cl
Show InChI InChI=1S/C28H28Cl2F3N3O5S/c1-40-25-17-26(41-19-7-5-18(6-8-19)27(37)34-11-14-36-12-3-2-4-13-36)24(16-23(25)30)35-42(38,39)20-9-10-22(29)21(15-20)28(31,32)33/h5-10,15-17,35H,2-4,11-14H2,1H3,(H,34,37)
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10n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359012
PNG
(CHEMBL1924013)
Show SMILES FC(F)(F)c1cc(ccc1Cl)S(=O)(=O)Nc1cc(Cl)ccc1Oc1ccc(cc1)C(=O)NCCN1CCCCC1
Show InChI InChI=1S/C27H26Cl2F3N3O4S/c28-19-6-11-25(24(16-19)34-40(37,38)21-9-10-23(29)22(17-21)27(30,31)32)39-20-7-4-18(5-8-20)26(36)33-12-15-35-13-2-1-3-14-35/h4-11,16-17,34H,1-3,12-15H2,(H,33,36)
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10n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401555
PNG
(CHEMBL2207101)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)Nc1cc(Cl)c(Cl)cc1Cn1ccnn1
Show InChI InChI=1S/C16H11Cl2F3N4O2S/c17-13-6-10(9-25-5-4-22-24-25)15(8-14(13)18)23-28(26,27)12-3-1-2-11(7-12)16(19,20)21/h1-8,23H,9H2
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12.6n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401546
PNG
(CHEMBL2207100)
Show SMILES Clc1ccc(s1)S(=O)(=O)Nc1cc(Cl)c(Cl)cc1Cn1ccnn1
Show InChI InChI=1S/C13H9Cl3N4O2S2/c14-9-5-8(7-20-4-3-17-19-20)11(6-10(9)15)18-24(21,22)13-2-1-12(16)23-13/h1-6,18H,7H2
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12.6n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359025
PNG
(CHEMBL1924005)
Show SMILES Clc1cnc(Oc2ccc(cc2)C(=O)NCCN2CCCC2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C24H23Cl3N4O4S/c25-17-13-22(30-36(33,34)19-7-8-20(26)21(27)14-19)24(29-15-17)35-18-5-3-16(4-6-18)23(32)28-9-12-31-10-1-2-11-31/h3-8,13-15,30H,1-2,9-12H2,(H,28,32)
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13n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359024
PNG
(CHEMBL1924004)
Show SMILES Clc1cnc(Oc2ccc(cc2)C(=O)NCCN2CCCCC2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C25H25Cl3N4O4S/c26-18-14-23(31-37(34,35)20-8-9-21(27)22(28)15-20)25(30-16-18)36-19-6-4-17(5-7-19)24(33)29-10-13-32-11-2-1-3-12-32/h4-9,14-16,31H,1-3,10-13H2,(H,29,33)
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13n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401553
PNG
(CHEMBL2207085)
Show SMILES Cn1nnnc1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H12Cl3N5O2S/c1-23-15(19-21-22-23)6-9-2-3-10(16)7-14(9)20-26(24,25)11-4-5-12(17)13(18)8-11/h2-5,7-8,20H,6H2,1H3
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15.8n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359014
PNG
(CHEMBL1924015)
Show SMILES Cc1cc(Oc2ccc(cc2)C(=O)NCCN2CCCCC2)c(NS(=O)(=O)c2ccc(Cl)c(c2)C(F)(F)F)cc1Cl
Show InChI InChI=1S/C28H28Cl2F3N3O4S/c1-18-15-26(40-20-7-5-19(6-8-20)27(37)34-11-14-36-12-3-2-4-13-36)25(17-24(18)30)35-41(38,39)21-9-10-23(29)22(16-21)28(31,32)33/h5-10,15-17,35H,2-4,11-14H2,1H3,(H,34,37)
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16n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359024
PNG
(CHEMBL1924004)
Show SMILES Clc1cnc(Oc2ccc(cc2)C(=O)NCCN2CCCCC2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C25H25Cl3N4O4S/c26-18-14-23(31-37(34,35)20-8-9-21(27)22(28)15-20)25(30-16-18)36-19-6-4-17(5-7-19)24(33)29-10-13-32-11-2-1-3-12-32/h4-9,14-16,31H,1-3,10-13H2,(H,29,33)
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20n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs in prese...


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359021
PNG
(CHEMBL1924022)
Show SMILES COc1cc(ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(c1)C(F)(F)F)C(=O)NCCN1CCCCC1
Show InChI InChI=1S/C28H28Cl2F3N3O5S/c1-40-26-15-18(27(37)34-11-14-36-12-3-2-4-13-36)5-9-25(26)41-24-10-6-19(29)16-23(24)35-42(38,39)20-7-8-22(30)21(17-20)28(31,32)33/h5-10,15-17,35H,2-4,11-14H2,1H3,(H,34,37)
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25n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359020
PNG
(CHEMBL1924021)
Show SMILES Cc1cc(ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(c1)C(F)(F)F)C(=O)NCCN1CCCCC1
Show InChI InChI=1S/C28H28Cl2F3N3O4S/c1-18-15-19(27(37)34-11-14-36-12-3-2-4-13-36)5-9-25(18)40-26-10-6-20(29)16-24(26)35-41(38,39)21-7-8-23(30)22(17-21)28(31,32)33/h5-10,15-17,35H,2-4,11-14H2,1H3,(H,34,37)
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25n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401548
PNG
(CHEMBL2207094)
Show SMILES Clc1cc(sc1Cl)S(=O)(=O)Nc1cc(Cl)ccc1Cn1ccnn1
Show InChI InChI=1S/C13H9Cl3N4O2S2/c14-9-2-1-8(7-20-4-3-17-19-20)11(5-9)18-24(21,22)12-6-10(15)13(16)23-12/h1-6,18H,7H2
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25.1n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401557
PNG
(CHEMBL2207099)
Show SMILES Cn1nnnc1Cc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H11Cl3N6O2S/c1-23-14(19-21-22-23)6-12-13(4-8(15)7-18-12)20-26(24,25)9-2-3-10(16)11(17)5-9/h2-5,7,20H,6H2,1H3
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25.1n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401552
PNG
(CHEMBL2207080)
Show SMILES Clc1ccc(Cn2nnnc2C2CC2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C17H14Cl3N5O2S/c18-12-4-3-11(9-25-17(10-1-2-10)21-23-24-25)16(7-12)22-28(26,27)13-5-6-14(19)15(20)8-13/h3-8,10,22H,1-2,9H2
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31.6n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401558
PNG
(CHEMBL2207097)
Show SMILES Fc1ccc(Cn2ccnn2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C15H11Cl2FN4O2S/c16-13-4-3-12(8-14(13)17)25(23,24)20-15-7-11(18)2-1-10(15)9-22-6-5-19-21-22/h1-8,20H,9H2
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31.6n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401554
PNG
(CHEMBL2207083)
Show SMILES Clc1ccc(Cn2cncn2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C15H11Cl3N4O2S/c16-11-2-1-10(7-22-9-19-8-20-22)15(5-11)21-25(23,24)12-3-4-13(17)14(18)6-12/h1-6,8-9,21H,7H2
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39.8n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359026
PNG
(CHEMBL1924006)
Show SMILES Clc1cnc(Oc2ccc(cc2)C(=O)NCCN2CCNCC2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C24H24Cl3N5O4S/c25-17-13-22(31-37(34,35)19-5-6-20(26)21(27)14-19)24(30-15-17)36-18-3-1-16(2-4-18)23(33)29-9-12-32-10-7-28-8-11-32/h1-6,13-15,28,31H,7-12H2,(H,29,33)
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40n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401556
PNG
(CHEMBL2207091)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)Nc1cc(Cl)ccc1Cn1ccnn1
Show InChI InChI=1S/C16H12ClF3N4O2S/c17-13-5-4-11(10-24-7-6-21-23-24)15(9-13)22-27(25,26)14-3-1-2-12(8-14)16(18,19)20/h1-9,22H,10H2
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50.1n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401559
PNG
(CHEMBL2207093)
Show SMILES Clc1ccc(s1)S(=O)(=O)Nc1cc(Cl)ccc1Cn1ccnn1
Show InChI InChI=1S/C13H10Cl2N4O2S2/c14-10-2-1-9(8-19-6-5-16-18-19)11(7-10)17-23(20,21)13-4-3-12(15)22-13/h1-7,17H,8H2
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50.1n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359025
PNG
(CHEMBL1924005)
Show SMILES Clc1cnc(Oc2ccc(cc2)C(=O)NCCN2CCCC2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C24H23Cl3N4O4S/c25-17-13-22(30-36(33,34)19-7-8-20(26)21(27)14-19)24(29-15-17)35-18-5-3-16(4-6-18)23(32)28-9-12-31-10-1-2-11-31/h3-8,13-15,30H,1-2,9-12H2,(H,28,32)
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63n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs in prese...


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359019
PNG
(CHEMBL1924020)
Show SMILES FC(F)(F)c1cc(ccc1Cl)S(=O)(=O)Nc1cc(Cl)ccc1Oc1ccc(cc1)C(=O)NCCN1CCC(F)(F)C1
Show InChI InChI=1S/C26H22Cl2F5N3O4S/c27-17-3-8-23(22(13-17)35-41(38,39)19-6-7-21(28)20(14-19)26(31,32)33)40-18-4-1-16(2-5-18)24(37)34-10-12-36-11-9-25(29,30)15-36/h1-8,13-14,35H,9-12,15H2,(H,34,37)
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63n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359033
PNG
(CHEMBL1924012)
Show SMILES Clc1ccc(Oc2ccc(cc2)C(=O)NCCN2CCCCC2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C26H26Cl3N3O4S/c27-19-6-11-25(24(16-19)31-37(34,35)21-9-10-22(28)23(29)17-21)36-20-7-4-18(5-8-20)26(33)30-12-15-32-13-2-1-3-14-32/h4-11,16-17,31H,1-3,12-15H2,(H,30,33)
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63n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401564
PNG
(CHEMBL2207095)
Show SMILES Clc1ccc(Cn2ccnn2)c(NS(=O)(=O)c2csc3ccccc23)c1
Show InChI InChI=1S/C17H13ClN4O2S2/c18-13-6-5-12(10-22-8-7-19-21-22)15(9-13)20-26(23,24)17-11-25-16-4-2-1-3-14(16)17/h1-9,11,20H,10H2
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63.1n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359027
PNG
(CHEMBL1924007)
Show SMILES Clc1cnc(Oc2cccc(c2)C(=O)NCCN2CCCCC2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C25H25Cl3N4O4S/c26-18-14-23(31-37(34,35)20-7-8-21(27)22(28)15-20)25(30-16-18)36-19-6-4-5-17(13-19)24(33)29-9-12-32-10-2-1-3-11-32/h4-8,13-16,31H,1-3,9-12H2,(H,29,33)
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79n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401549
PNG
(CHEMBL2207081)
Show SMILES Clc1ccc(Cn2ccnn2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C15H11Cl3N4O2S/c16-11-2-1-10(9-22-6-5-19-21-22)15(7-11)20-25(23,24)12-3-4-13(17)14(18)8-12/h1-8,20H,9H2
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79.4n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 assessed as inhibition of CCL2-stimulated THP-1 cell chemotaxis in presence of 0.1% human serum


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401550
PNG
(CHEMBL2207084)
Show SMILES Cc1nnnn1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H12Cl3N5O2S/c1-9-19-21-22-23(9)8-10-2-3-11(16)6-15(10)20-26(24,25)12-4-5-13(17)14(18)7-12/h2-7,20H,8H2,1H3
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79.4n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 assessed as inhibition of CCL2-stimulated THP-1 cell chemotaxis in presence of 0.1% human serum


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401550
PNG
(CHEMBL2207084)
Show SMILES Cc1nnnn1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H12Cl3N5O2S/c1-9-19-21-22-23(9)8-10-2-3-11(16)6-15(10)20-26(24,25)12-4-5-13(17)14(18)7-12/h2-7,20H,8H2,1H3
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79.4n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 assessed as inhibition of CCL2-stimulated THP-1 cell chemotaxis in presence of 1% human serum


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401560
PNG
(CHEMBL2207087)
Show SMILES Clc1ccc(cc1)S(=O)(=O)Nc1cc(Cl)ccc1Cn1ccnn1
Show InChI InChI=1S/C15H12Cl2N4O2S/c16-12-3-5-14(6-4-12)24(22,23)19-15-9-13(17)2-1-11(15)10-21-8-7-18-20-21/h1-9,19H,10H2
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100n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359028
PNG
(CHEMBL1924008)
Show SMILES Clc1cnc(Oc2cccc(c2)C(=O)NCCN2CCCC2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C24H23Cl3N4O4S/c25-17-13-22(30-36(33,34)19-6-7-20(26)21(27)14-19)24(29-15-17)35-18-5-3-4-16(12-18)23(32)28-8-11-31-9-1-2-10-31/h3-7,12-15,30H,1-2,8-11H2,(H,28,32)
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100n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401562
PNG
(CHEMBL2207088)
Show SMILES Clc1cccc(c1)S(=O)(=O)Nc1cc(Cl)ccc1Cn1ccnn1
Show InChI InChI=1S/C15H12Cl2N4O2S/c16-12-2-1-3-14(8-12)24(22,23)19-15-9-13(17)5-4-11(15)10-21-7-6-18-20-21/h1-9,19H,10H2
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100n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401565
PNG
(CHEMBL2207090)
Show SMILES Fc1cccc(c1)S(=O)(=O)Nc1cc(Cl)ccc1Cn1ccnn1
Show InChI InChI=1S/C15H12ClFN4O2S/c16-12-5-4-11(10-21-7-6-18-20-21)15(8-12)19-24(22,23)14-3-1-2-13(17)9-14/h1-9,19H,10H2
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100n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR2 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401552
PNG
(CHEMBL2207080)
Show SMILES Clc1ccc(Cn2nnnc2C2CC2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C17H14Cl3N5O2S/c18-12-4-3-11(9-25-17(10-1-2-10)21-23-24-25)16(7-12)22-28(26,27)13-5-6-14(19)15(20)8-13/h3-8,10,22H,1-2,9H2
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100n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 assessed as inhibition of CCL2-stimulated THP-1 cell chemotaxis in presence of 0.1% human serum


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401552
PNG
(CHEMBL2207080)
Show SMILES Clc1ccc(Cn2nnnc2C2CC2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C17H14Cl3N5O2S/c18-12-4-3-11(9-25-17(10-1-2-10)21-23-24-25)16(7-12)22-28(26,27)13-5-6-14(19)15(20)8-13/h3-8,10,22H,1-2,9H2
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100n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 assessed as inhibition of CCL2-stimulated THP-1 cell chemotaxis in presence of 1% human serum


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50401549
PNG
(CHEMBL2207081)
Show SMILES Clc1ccc(Cn2ccnn2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C15H11Cl3N4O2S/c16-11-2-1-10(9-22-6-5-19-21-22)15(7-11)20-25(23,24)12-3-4-13(17)14(18)8-12/h1-8,20H,9H2
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100n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 assessed as inhibition of CCL2-stimulated THP-1 cell chemotaxis in presence of 1% human serum


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4 (CCR4)


(Homo sapiens (Human))
BDBM50401547
PNG
(CHEMBL2207098)
Show SMILES Clc1ccc(cc1Cl)S(=O)(=O)Nc1cc(Cl)c(Cl)cc1Cn1ccnn1
Show InChI InChI=1S/C15H10Cl4N4O2S/c16-11-2-1-10(6-13(11)18)26(24,25)21-15-7-14(19)12(17)5-9(15)8-23-4-3-20-22-23/h1-7,21H,8H2
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158n/an/an/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to CCR4 by 35S-gamma-GTP membrane assay


Bioorg Med Chem Lett 22: 7252-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.020
BindingDB Entry DOI: 10.7270/Q21J9BZJ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359029
PNG
(CHEMBL1924009)
Show SMILES Clc1cnc(Oc2cccc(c2)C(=O)NCCN2CCNCC2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C24H24Cl3N5O4S/c25-17-13-22(31-37(34,35)19-4-5-20(26)21(27)14-19)24(30-15-17)36-18-3-1-2-16(12-18)23(33)29-8-11-32-9-6-28-7-10-32/h1-5,12-15,28,31H,6-11H2,(H,29,33)
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200n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50359026
PNG
(CHEMBL1924006)
Show SMILES Clc1cnc(Oc2ccc(cc2)C(=O)NCCN2CCNCC2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C24H24Cl3N5O4S/c25-17-13-22(31-37(34,35)19-5-6-20(26)21(27)14-19)24(30-15-17)36-18-3-1-16(2-4-18)23(33)29-9-12-32-10-7-28-8-11-32/h1-6,13-15,28,31H,7-12H2,(H,29,33)
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251n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs in prese...


Bioorg Med Chem Lett 21: 7291-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.038
BindingDB Entry DOI: 10.7270/Q2KK9C6D
More data for this
Ligand-Target Pair
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