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Compile Data Set for Download or QSAR

Found 245 hits with Last Name = 'graus porta' and Initial = 'd'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50355393
PNG
(CHEMBL1834657 | US9434697, BGJ398 | US9730931, BGJ...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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n/an/a 0.700n/an/an/an/an/an/a



Novartis Institute for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of FGFR3 juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct


J Med Chem 54: 7066-83 (2011)


Article DOI: 10.1021/jm2006222
BindingDB Entry DOI: 10.7270/Q22N52N1
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50355393
PNG
(CHEMBL1834657 | US9434697, BGJ398 | US9730931, BGJ...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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n/an/a 0.900n/an/an/an/an/an/a



Novartis Institute for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR1


J Med Chem 54: 7066-83 (2011)


Article DOI: 10.1021/jm2006222
BindingDB Entry DOI: 10.7270/Q22N52N1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50355393
PNG
(CHEMBL1834657 | US9434697, BGJ398 | US9730931, BGJ...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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n/an/a 1n/an/an/an/an/an/a



Novartis Institute for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR3


J Med Chem 54: 7066-83 (2011)


Article DOI: 10.1021/jm2006222
BindingDB Entry DOI: 10.7270/Q22N52N1
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50355393
PNG
(CHEMBL1834657 | US9434697, BGJ398 | US9730931, BGJ...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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n/an/a 1.40n/an/an/an/an/an/a



Novartis Institute for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR2


J Med Chem 54: 7066-83 (2011)


Article DOI: 10.1021/jm2006222
BindingDB Entry DOI: 10.7270/Q22N52N1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50355393
PNG
(CHEMBL1834657 | US9434697, BGJ398 | US9730931, BGJ...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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n/an/a 2n/an/an/an/an/an/a



Novartis Institute for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of FGFR2 juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct


J Med Chem 54: 7066-83 (2011)


Article DOI: 10.1021/jm2006222
BindingDB Entry DOI: 10.7270/Q22N52N1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50355393
PNG
(CHEMBL1834657 | US9434697, BGJ398 | US9730931, BGJ...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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n/an/a 2n/an/an/an/an/an/a



Novartis Institute for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of FGFR3-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct


J Med Chem 54: 7066-83 (2011)


Article DOI: 10.1021/jm2006222
BindingDB Entry DOI: 10.7270/Q22N52N1
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50355393
PNG
(CHEMBL1834657 | US9434697, BGJ398 | US9730931, BGJ...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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n/an/a 2.90n/an/an/an/an/an/a



Novartis Institute for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of FGFR1-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct


J Med Chem 54: 7066-83 (2011)


Article DOI: 10.1021/jm2006222
BindingDB Entry DOI: 10.7270/Q22N52N1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50355393
PNG
(CHEMBL1834657 | US9434697, BGJ398 | US9730931, BGJ...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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n/an/a 4.60n/an/an/an/an/an/a



Novartis Institute for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of wild type FGFR1 expressed in HEK293 cells assessed as inhibition of autophosphorylation of tyrosine residue after 40 mins by ELISA assa...


J Med Chem 54: 7066-83 (2011)


Article DOI: 10.1021/jm2006222
BindingDB Entry DOI: 10.7270/Q22N52N1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50355393
PNG
(CHEMBL1834657 | US9434697, BGJ398 | US9730931, BGJ...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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n/an/a 4.90n/an/an/an/an/an/a



Novartis Institute for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of wild type FGFR2 expressed in HEK293 cells assessed as inhibition of autophosphorylation of tyrosine residue after 40 mins by ELISA assa...


J Med Chem 54: 7066-83 (2011)


Article DOI: 10.1021/jm2006222
BindingDB Entry DOI: 10.7270/Q22N52N1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM130075
PNG
(US8815901, 93)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCCC3)[nH]2)c2nccnc12 |(10.31,-2.67,;8.77,-2.67,;8,-1.33,;8.77,,;8,1.33,;8.77,2.67,;8,4,;6.46,1.33,;5.69,2.67,;5.69,,;6.46,-1.33,;5.69,-2.67,;4.15,,;3.38,1.33,;1.84,1.33,;1.07,,;-.47,,;-1.24,1.33,;-1.24,-1.33,;-2.78,-1.33,;-3.69,-.09,;-5.15,-.56,;-5.15,-2.1,;-6.48,-2.87,;-7.82,-2.1,;-8.29,-.64,;-9.83,-.64,;-10.31,-2.1,;-9.06,-3.01,;-3.69,-2.58,;1.84,-1.33,;1.07,-2.67,;1.84,-4,;3.38,-4,;4.15,-2.67,;3.38,-1.33,)|
Show InChI InChI=1S/C25H24F2N6O3/c1-35-17-11-18(36-2)21(27)19(20(17)26)15-5-6-16(23-22(15)28-7-8-29-23)24(34)32-25-30-12-14(31-25)13-33-9-3-4-10-33/h5-8,11-12H,3-4,9-10,13H2,1-2H3,(H2,30,31,32,34)
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US Patent
n/an/a 7n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102526
PNG
(US8536175, 93)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCCC3)[nH]2)c2nccnc12 |(10.25,-2.72,;8.71,-2.72,;7.94,-1.38,;8.71,-.05,;7.94,1.28,;8.71,2.62,;7.94,3.95,;6.4,1.28,;5.63,2.62,;5.63,-.05,;6.4,-1.38,;5.63,-2.72,;4.09,-.05,;3.32,1.28,;1.78,1.28,;1.01,-.05,;-.53,-.05,;-1.3,1.28,;-1.3,-1.38,;-2.84,-1.38,;-3.74,-.14,;-5.21,-.61,;-5.21,-2.15,;-6.54,-2.92,;-7.88,-2.15,;-8.35,-.69,;-9.89,-.69,;-10.37,-2.15,;-9.12,-3.06,;-3.74,-2.63,;1.78,-1.38,;1.01,-2.72,;1.78,-4.05,;3.32,-4.05,;4.09,-2.72,;3.32,-1.38,)|
Show InChI InChI=1S/C25H24F2N6O3/c1-35-17-11-18(36-2)21(27)19(20(17)26)15-5-6-16(23-22(15)28-7-8-29-23)24(34)32-25-30-12-14(31-25)13-33-9-3-4-10-33/h5-8,11-12H,3-4,9-10,13H2,1-2H3,(H2,30,31,32,34)
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n/an/a 7n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102540
PNG
(US8536175, 144)
Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2nccnc12 |(8.07,3.99,;8.84,2.66,;8.07,1.32,;8.84,-.01,;8.07,-1.34,;8.84,-2.68,;10.38,-2.68,;6.53,-1.34,;5.76,-2.68,;5.76,-.01,;6.53,1.32,;5.76,2.66,;4.22,-.01,;3.45,1.32,;1.91,1.32,;1.14,-.01,;-.4,-.01,;-1.17,1.32,;-1.17,-1.34,;-2.71,-1.34,;-3.48,-.01,;-5.02,-.01,;-5.79,-1.34,;-7.33,-1.34,;-8.1,-.01,;-9.64,-.01,;-10.41,1.32,;-9.64,2.66,;-10.41,3.99,;-8.1,2.66,;-7.33,1.32,;-5.02,-2.68,;-3.48,-2.68,;1.91,-1.34,;1.14,-2.68,;1.91,-4.01,;3.45,-4.01,;4.22,-2.68,;3.45,-1.34,)|
Show InChI InChI=1S/C28H28ClFN6O3/c1-35-10-12-36(13-11-35)16-17-4-7-22(33-15-17)34-28(37)19-6-5-18(26-27(19)32-9-8-31-26)23-24(29)20(38-2)14-21(39-3)25(23)30/h4-9,14-15H,10-13,16H2,1-3H3,(H,33,34,37)
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n/an/a 7n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102540
PNG
(US8536175, 144)
Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2nccnc12 |(8.07,3.99,;8.84,2.66,;8.07,1.32,;8.84,-.01,;8.07,-1.34,;8.84,-2.68,;10.38,-2.68,;6.53,-1.34,;5.76,-2.68,;5.76,-.01,;6.53,1.32,;5.76,2.66,;4.22,-.01,;3.45,1.32,;1.91,1.32,;1.14,-.01,;-.4,-.01,;-1.17,1.32,;-1.17,-1.34,;-2.71,-1.34,;-3.48,-.01,;-5.02,-.01,;-5.79,-1.34,;-7.33,-1.34,;-8.1,-.01,;-9.64,-.01,;-10.41,1.32,;-9.64,2.66,;-10.41,3.99,;-8.1,2.66,;-7.33,1.32,;-5.02,-2.68,;-3.48,-2.68,;1.91,-1.34,;1.14,-2.68,;1.91,-4.01,;3.45,-4.01,;4.22,-2.68,;3.45,-1.34,)|
Show InChI InChI=1S/C28H28ClFN6O3/c1-35-10-12-36(13-11-35)16-17-4-7-22(33-15-17)34-28(37)19-6-5-18(26-27(19)32-9-8-31-26)23-24(29)20(38-2)14-21(39-3)25(23)30/h4-9,14-15H,10-13,16H2,1-3H3,(H,33,34,37)
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n/an/a 7n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102543
PNG
(US8536175, 154)
Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCN(C)CC3)[nH]2)c2nccnc12 |(8.75,4,;9.52,2.67,;8.75,1.33,;9.52,,;8.75,-1.33,;9.52,-2.67,;11.06,-2.67,;7.21,-1.33,;6.44,-2.67,;6.44,,;7.21,1.33,;6.44,2.67,;4.9,,;4.13,1.33,;2.59,1.33,;1.82,,;.28,,;-.49,1.33,;-.49,-1.33,;-2.03,-1.33,;-2.93,-.09,;-4.4,-.56,;-4.4,-2.1,;-5.73,-2.87,;-7.06,-2.1,;-7.06,-.56,;-8.4,.21,;-9.73,-.56,;-11.06,.21,;-9.73,-2.1,;-8.4,-2.87,;-2.93,-2.58,;2.59,-1.33,;1.82,-2.67,;2.59,-4,;4.13,-4,;4.9,-2.67,;4.13,-1.33,)|
Show InChI InChI=1S/C26H27ClFN7O3/c1-34-8-10-35(11-9-34)14-15-13-31-26(32-15)33-25(36)17-5-4-16(23-24(17)30-7-6-29-23)20-21(27)18(37-2)12-19(38-3)22(20)28/h4-7,12-13H,8-11,14H2,1-3H3,(H2,31,32,33,36)
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n/an/a 9n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM130083
PNG
(US8815901, 175)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2ncccc12 |(9.64,-2.74,;8.1,-2.74,;7.33,-1.41,;8.1,-.08,;7.33,1.26,;8.1,2.59,;7.33,3.93,;5.79,1.26,;5.02,2.59,;5.02,-.08,;5.79,-1.41,;5.02,-2.74,;3.48,-.08,;2.71,1.26,;1.17,1.26,;.4,-.08,;-1.14,-.08,;-1.91,1.26,;-1.91,-1.41,;-3.44,-1.41,;-4.34,-.16,;-5.81,-.64,;-5.81,-2.18,;-7.14,-2.95,;-8.48,-2.18,;-9.81,-2.95,;-8.48,-.64,;-4.34,-2.65,;1.17,-1.41,;.4,-2.74,;1.17,-4.08,;2.71,-4.08,;3.48,-2.74,;2.71,-1.41,)|
Show InChI InChI=1S/C24H23F2N5O3/c1-31(2)12-13-11-28-24(29-13)30-23(32)16-8-7-14(15-6-5-9-27-22(15)16)19-20(25)17(33-3)10-18(34-4)21(19)26/h5-11H,12H2,1-4H3,(H2,28,29,30,32)
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n/an/a 9n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102549
PNG
(US8536175, 175)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2ncccc12 |(9.73,-2.67,;8.19,-2.67,;7.42,-1.34,;8.19,-0,;7.42,1.33,;8.19,2.66,;7.42,4,;5.88,1.33,;5.11,2.66,;5.11,-0,;5.88,-1.34,;5.11,-2.67,;3.57,-0,;2.8,1.33,;1.26,1.33,;.49,-0,;-1.05,-0,;-1.82,1.33,;-1.82,-1.34,;-3.36,-1.34,;-4.27,-.09,;-5.73,-.57,;-5.73,-2.11,;-7.07,-2.88,;-8.4,-2.11,;-9.74,-2.88,;-8.4,-.57,;-4.27,-2.58,;1.26,-1.34,;.49,-2.67,;1.26,-4.01,;2.8,-4.01,;3.57,-2.67,;2.8,-1.34,)|
Show InChI InChI=1S/C24H23F2N5O3/c1-31(2)12-13-11-28-24(29-13)30-23(32)16-8-7-14(15-6-5-9-27-22(15)16)19-20(25)17(33-3)10-18(34-4)21(19)26/h5-11H,12H2,1-4H3,(H2,28,29,30,32)
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n/an/a 9n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM130080
PNG
(US8815901, 154)
Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCN(C)CC3)[nH]2)c2nccnc12 |(8.7,3.96,;9.47,2.62,;8.7,1.29,;9.47,-.04,;8.7,-1.38,;9.47,-2.71,;11.01,-2.71,;7.16,-1.38,;6.39,-2.71,;6.39,-.04,;7.16,1.29,;6.39,2.62,;4.85,-.04,;4.08,1.29,;2.54,1.29,;1.77,-.04,;.23,-.04,;-.54,1.29,;-.54,-1.38,;-2.08,-1.38,;-2.98,-.13,;-4.45,-.61,;-4.45,-2.15,;-5.78,-2.92,;-7.11,-2.15,;-7.11,-.61,;-8.45,.16,;-9.78,-.61,;-11.12,.16,;-9.78,-2.15,;-8.45,-2.92,;-2.98,-2.62,;2.54,-1.38,;1.77,-2.71,;2.54,-4.05,;4.08,-4.05,;4.85,-2.71,;4.08,-1.38,)|
Show InChI InChI=1S/C26H27ClFN7O3/c1-34-8-10-35(11-9-34)14-15-13-31-26(32-15)33-25(36)17-5-4-16(23-24(17)30-7-6-29-23)20-21(27)18(37-2)12-19(38-3)22(20)28/h4-7,12-13H,8-11,14H2,1-3H3,(H2,31,32,33,36)
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n/an/a 9n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102534
PNG
(US8536175, 124)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2nccnc12 |(10.39,-2.67,;8.85,-2.67,;8.08,-1.33,;8.85,,;8.08,1.33,;8.85,2.67,;8.08,4,;6.54,1.33,;5.78,2.67,;5.78,,;6.54,-1.33,;5.78,-2.67,;4.23,,;3.47,1.33,;1.93,1.33,;1.15,,;-.38,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.47,,;-5,,;-5.78,-1.33,;-7.31,-1.33,;-8.08,,;-7.31,1.33,;-8.08,2.67,;-9.63,2.67,;-10.39,4,;-10.39,1.33,;-9.63,,;-5,-2.67,;-3.47,-2.67,;1.93,-1.33,;1.15,-2.67,;1.93,-4,;3.47,-4,;4.23,-2.67,;3.47,-1.33,)|
Show InChI InChI=1S/C28H28F2N6O3/c1-35-10-12-36(13-11-35)16-17-4-7-22(33-15-17)34-28(37)19-6-5-18(26-27(19)32-9-8-31-26)23-24(29)20(38-2)14-21(39-3)25(23)30/h4-9,14-15H,10-13,16H2,1-3H3,(H,33,34,37)
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Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM130084
PNG
(US8815901, 177)
Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2ncccc12 |(7.33,3.93,;8.1,2.59,;7.33,1.26,;8.1,-.08,;7.33,-1.41,;8.1,-2.74,;9.64,-2.74,;5.79,-1.41,;5.02,-2.74,;5.02,-.08,;5.79,1.26,;5.02,2.59,;3.48,-.08,;2.71,1.26,;1.17,1.26,;.4,-.08,;-1.14,-.08,;-1.91,1.26,;-1.91,-1.41,;-3.44,-1.41,;-4.34,-.16,;-5.81,-.64,;-5.81,-2.18,;-7.14,-2.95,;-8.48,-2.18,;-9.81,-2.95,;-8.48,-.64,;-4.34,-2.65,;1.17,-1.41,;.4,-2.74,;1.17,-4.08,;2.71,-4.08,;3.48,-2.74,;2.71,-1.41,)|
Show InChI InChI=1S/C24H23ClFN5O3/c1-31(2)12-13-11-28-24(29-13)30-23(32)16-8-7-14(15-6-5-9-27-22(15)16)19-20(25)17(33-3)10-18(34-4)21(19)26/h5-11H,12H2,1-4H3,(H2,28,29,30,32)
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Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM130076
PNG
(US8815901, 124)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCNCC3)cn2)c2nccnc12 |(10.39,-2.67,;8.85,-2.67,;8.08,-1.33,;8.85,,;8.08,1.33,;8.85,2.67,;8.08,4,;6.54,1.33,;5.78,2.67,;5.78,,;6.54,-1.33,;5.78,-2.67,;4.23,,;3.47,1.33,;1.93,1.33,;1.15,,;-.38,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.47,,;-5,,;-5.78,-1.33,;-7.31,-1.33,;-8.08,,;-7.31,1.33,;-8.08,2.67,;-9.63,2.67,;-10.39,1.33,;-9.63,,;-5,-2.67,;-3.47,-2.67,;1.93,-1.33,;1.15,-2.67,;1.93,-4,;3.47,-4,;4.23,-2.67,;3.47,-1.33,)|
Show InChI InChI=1S/C27H26F2N6O3/c1-37-19-13-20(38-2)24(29)22(23(19)28)17-4-5-18(26-25(17)31-7-8-32-26)27(36)34-21-6-3-16(14-33-21)15-35-11-9-30-10-12-35/h3-8,13-14,30H,9-12,15H2,1-2H3,(H,33,34,36)
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Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM130069
PNG
(US8815901, 22)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2nccnc12 |(7.31,3.91,;8.08,2.57,;7.31,1.24,;8.08,-.1,;7.31,-1.43,;8.08,-2.76,;9.62,-2.76,;5.77,-1.43,;5,-2.76,;5,-.1,;5.77,1.24,;5,2.57,;3.46,-.1,;2.69,1.24,;1.15,1.24,;.38,-.1,;-1.16,-.1,;-1.93,1.24,;-1.93,-1.43,;-3.47,-1.43,;-4.37,-.18,;-5.84,-.66,;-5.84,-2.2,;-7.17,-2.97,;-8.51,-2.2,;-9.84,-2.97,;-8.51,-.66,;-4.37,-2.67,;1.15,-1.43,;.38,-2.76,;1.15,-4.1,;2.69,-4.1,;3.46,-2.76,;2.69,-1.43,)|
Show InChI InChI=1S/C23H22Cl2N6O3/c1-31(2)11-12-10-28-23(29-12)30-22(32)14-6-5-13(20-21(14)27-8-7-26-20)17-18(24)15(33-3)9-16(34-4)19(17)25/h5-10H,11H2,1-4H3,(H2,28,29,30,32)
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Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102509
PNG
(US8536175, 22)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2nccnc12 |(7.42,4,;8.19,2.67,;7.42,1.33,;8.19,,;7.42,-1.33,;8.19,-2.67,;9.73,-2.67,;5.88,-1.33,;5.11,-2.67,;5.11,,;5.88,1.33,;5.11,2.67,;3.57,,;2.8,1.33,;1.26,1.33,;.49,,;-1.05,,;-1.82,1.33,;-1.82,-1.33,;-3.36,-1.33,;-4.26,-.09,;-5.73,-.56,;-5.73,-2.1,;-7.06,-2.87,;-8.4,-2.1,;-8.4,-.56,;-9.73,-2.87,;-4.26,-2.58,;1.26,-1.33,;.49,-2.67,;1.26,-4,;2.8,-4,;3.57,-2.67,;2.8,-1.33,)|
Show InChI InChI=1S/C23H22Cl2N6O3/c1-31(2)11-12-10-28-23(29-12)30-22(32)14-6-5-13(20-21(14)27-8-7-26-20)17-18(24)15(33-3)9-16(34-4)19(17)25/h5-10H,11H2,1-4H3,(H2,28,29,30,32)
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n/an/a 10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102551
PNG
(US8536175, 177)
Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2ncccc12 |(7.42,4,;8.19,2.66,;7.42,1.33,;8.19,-0,;7.42,-1.34,;8.19,-2.67,;9.73,-2.67,;5.88,-1.34,;5.11,-2.67,;5.11,-0,;5.88,1.33,;5.11,2.66,;3.57,-0,;2.8,1.33,;1.26,1.33,;.49,-0,;-1.05,-0,;-1.82,1.33,;-1.82,-1.34,;-3.36,-1.34,;-4.27,-.09,;-5.73,-.57,;-5.73,-2.11,;-7.07,-2.88,;-8.4,-2.11,;-9.74,-2.88,;-8.4,-.57,;-4.27,-2.58,;1.26,-1.34,;.49,-2.67,;1.26,-4.01,;2.8,-4.01,;3.57,-2.67,;2.8,-1.34,)|
Show InChI InChI=1S/C24H23ClFN5O3/c1-31(2)12-13-11-28-24(29-13)30-23(32)16-8-7-14(15-6-5-9-27-22(15)16)19-20(25)17(33-3)10-18(34-4)21(19)26/h5-11H,12H2,1-4H3,(H2,28,29,30,32)
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n/an/a 10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM130078
PNG
(US8815901, 135)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCOCC3)[nH]2)c2nccnc12 |(10.4,-2.67,;8.86,-2.67,;8.09,-1.33,;8.86,,;8.09,1.33,;8.86,2.67,;8.09,4,;6.55,1.33,;5.78,2.67,;5.78,,;6.55,-1.33,;5.78,-2.67,;4.24,,;3.47,1.33,;1.93,1.33,;1.16,,;-.38,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.6,-.09,;-5.06,-.56,;-5.06,-2.1,;-6.4,-2.87,;-7.73,-2.1,;-7.73,-.56,;-9.06,.21,;-10.4,-.56,;-10.4,-2.1,;-9.06,-2.87,;-3.6,-2.58,;1.93,-1.33,;1.16,-2.67,;1.93,-4,;3.47,-4,;4.24,-2.67,;3.47,-1.33,)|
Show InChI InChI=1S/C25H24F2N6O4/c1-35-17-11-18(36-2)21(27)19(20(17)26)15-3-4-16(23-22(15)28-5-6-29-23)24(34)32-25-30-12-14(31-25)13-33-7-9-37-10-8-33/h3-6,11-12H,7-10,13H2,1-2H3,(H2,30,31,32,34)
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n/an/a 11n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102536
PNG
(US8536175, 135)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCOCC3)[nH]2)c2nccnc12 |(8.07,3.99,;8.85,2.66,;8.08,1.32,;8.85,-.01,;8.08,-1.34,;8.85,-2.68,;10.39,-2.68,;6.54,-1.34,;5.77,-2.68,;5.77,-.01,;6.54,1.32,;5.77,2.66,;4.23,-.01,;3.46,1.32,;1.92,1.32,;1.15,-.01,;-.39,-.01,;-1.16,1.32,;-1.16,-1.34,;-2.7,-1.34,;-3.61,-.1,;-5.07,-.57,;-5.07,-2.11,;-6.41,-2.88,;-7.74,-2.11,;-7.74,-.57,;-9.08,.2,;-10.41,-.57,;-10.41,-2.11,;-9.08,-2.88,;-3.61,-2.59,;1.92,-1.34,;1.15,-2.68,;1.92,-4.01,;3.46,-4.01,;4.23,-2.68,;3.46,-1.34,)|
Show InChI InChI=1S/C25H24F2N6O4/c1-35-17-11-18(36-2)21(27)19(20(17)26)15-3-4-16(23-22(15)28-5-6-29-23)24(34)32-25-30-12-14(31-25)13-33-7-9-37-10-8-33/h3-6,11-12H,7-10,13H2,1-2H3,(H2,30,31,32,34)
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n/an/a 11n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102537
PNG
(US8536175, 136)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ccc(CN(C)CC(N)=O)cn2)c2nccnc12 |(11.15,2.66,;9.61,2.66,;8.84,1.32,;9.61,-.01,;8.84,-1.34,;9.61,-2.68,;11.15,-2.68,;7.3,-1.34,;6.53,-2.68,;6.53,-.01,;7.3,1.32,;6.53,2.66,;4.99,-.01,;4.22,1.32,;2.68,1.32,;1.91,-.01,;.37,-.01,;-.4,1.32,;-.4,-1.34,;-1.94,-1.34,;-2.71,-.01,;-4.25,-.01,;-5.02,-1.34,;-6.56,-1.34,;-7.33,-.01,;-6.56,1.32,;-8.87,-.01,;-9.64,1.32,;-8.87,2.66,;-11.18,1.32,;-4.25,-2.68,;-2.71,-2.68,;2.68,-1.34,;1.91,-2.68,;2.68,-4.01,;4.22,-4.01,;4.99,-2.68,;4.22,-1.34,)|
Show InChI InChI=1S/C26H24F2N6O4/c1-34(13-19(29)35)12-14-4-7-20(32-11-14)33-26(36)16-6-5-15(24-25(16)31-9-8-30-24)21-22(27)17(37-2)10-18(38-3)23(21)28/h4-11H,12-13H2,1-3H3,(H2,29,35)(H,32,33,36)
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n/an/a 11n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM130079
PNG
(US8815901, 153)
Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2nccnc12 |(7.37,3.96,;8.14,2.62,;7.37,1.29,;8.14,-.04,;7.37,-1.38,;8.14,-2.71,;9.68,-2.71,;5.83,-1.38,;5.06,-2.71,;5.06,-.04,;5.83,1.29,;5.06,2.62,;3.52,-.04,;2.75,1.29,;1.21,1.29,;.44,-.04,;-1.1,-.04,;-1.87,1.29,;-1.87,-1.38,;-3.41,-1.38,;-4.32,-.13,;-5.78,-.61,;-5.78,-2.15,;-7.11,-2.92,;-8.45,-2.15,;-9.78,-2.92,;-8.45,-.61,;-4.32,-2.62,;1.21,-1.38,;.44,-2.71,;1.21,-4.05,;2.75,-4.05,;3.52,-2.71,;2.75,-1.38,)|
Show InChI InChI=1S/C23H22ClFN6O3/c1-31(2)11-12-10-28-23(29-12)30-22(32)14-6-5-13(20-21(14)27-8-7-26-20)17-18(24)15(33-3)9-16(34-4)19(17)25/h5-10H,11H2,1-4H3,(H2,28,29,30,32)
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n/an/a 11n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102542
PNG
(US8536175, 153)
Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2nccnc12 |(7.42,4,;8.19,2.67,;7.42,1.33,;8.19,,;7.42,-1.33,;8.19,-2.67,;9.73,-2.67,;5.88,-1.33,;5.11,-2.67,;5.11,,;5.88,1.33,;5.11,2.67,;3.57,,;2.8,1.33,;1.26,1.33,;.49,,;-1.05,,;-1.82,1.33,;-1.82,-1.33,;-3.36,-1.33,;-4.26,-.09,;-5.73,-.56,;-5.73,-2.1,;-7.06,-2.87,;-8.4,-2.1,;-9.73,-2.87,;-8.4,-.56,;-4.26,-2.58,;1.26,-1.33,;.49,-2.67,;1.26,-4,;2.8,-4,;3.57,-2.67,;2.8,-1.33,)|
Show InChI InChI=1S/C23H22ClFN6O3/c1-31(2)11-12-10-28-23(29-12)30-22(32)14-6-5-13(20-21(14)27-8-7-26-20)17-18(24)15(33-3)9-16(34-4)19(17)25/h5-10H,11H2,1-4H3,(H2,28,29,30,32)
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n/an/a 11n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102537
PNG
(US8536175, 136)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ccc(CN(C)CC(N)=O)cn2)c2nccnc12 |(11.15,2.66,;9.61,2.66,;8.84,1.32,;9.61,-.01,;8.84,-1.34,;9.61,-2.68,;11.15,-2.68,;7.3,-1.34,;6.53,-2.68,;6.53,-.01,;7.3,1.32,;6.53,2.66,;4.99,-.01,;4.22,1.32,;2.68,1.32,;1.91,-.01,;.37,-.01,;-.4,1.32,;-.4,-1.34,;-1.94,-1.34,;-2.71,-.01,;-4.25,-.01,;-5.02,-1.34,;-6.56,-1.34,;-7.33,-.01,;-6.56,1.32,;-8.87,-.01,;-9.64,1.32,;-8.87,2.66,;-11.18,1.32,;-4.25,-2.68,;-2.71,-2.68,;2.68,-1.34,;1.91,-2.68,;2.68,-4.01,;4.22,-4.01,;4.99,-2.68,;4.22,-1.34,)|
Show InChI InChI=1S/C26H24F2N6O4/c1-34(13-19(29)35)12-14-4-7-20(32-11-14)33-26(36)16-6-5-15(24-25(16)31-9-8-30-24)21-22(27)17(37-2)10-18(38-3)23(21)28/h4-11H,12-13H2,1-3H3,(H2,29,35)(H,32,33,36)
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n/an/a 11n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102544
PNG
(US8536175, 155)
Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCNC(=O)C3)[nH]2)c2nccnc12 |(8.75,4,;9.52,2.67,;8.75,1.33,;9.52,,;8.75,-1.33,;9.52,-2.67,;11.06,-2.67,;7.21,-1.33,;6.44,-2.67,;6.44,,;7.21,1.33,;6.44,2.67,;4.9,,;4.13,1.33,;2.59,1.33,;1.82,,;.28,,;-.49,1.33,;-.49,-1.33,;-2.03,-1.33,;-2.93,-.09,;-4.4,-.56,;-4.4,-2.1,;-5.73,-2.87,;-7.06,-2.1,;-7.06,-.56,;-8.4,.21,;-9.73,-.56,;-9.73,-2.1,;-11.06,-2.87,;-8.4,-2.87,;-2.93,-2.58,;2.59,-1.33,;1.82,-2.67,;2.59,-4,;4.13,-4,;4.9,-2.67,;4.13,-1.33,)|
Show InChI InChI=1S/C25H23ClFN7O4/c1-37-16-9-17(38-2)21(27)19(20(16)26)14-3-4-15(23-22(14)29-5-6-30-23)24(36)33-25-31-10-13(32-25)11-34-8-7-28-18(35)12-34/h3-6,9-10H,7-8,11-12H2,1-2H3,(H,28,35)(H2,31,32,33,36)
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n/an/a 12n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM130081
PNG
(US8815901, 155)
Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCNC(=O)C3)[nH]2)c2nccnc12 |(8.7,3.96,;9.47,2.62,;8.7,1.29,;9.47,-.04,;8.7,-1.38,;9.47,-2.71,;11.01,-2.71,;7.16,-1.38,;6.39,-2.71,;6.39,-.04,;7.16,1.29,;6.39,2.62,;4.85,-.04,;4.08,1.29,;2.54,1.29,;1.77,-.04,;.23,-.04,;-.54,1.29,;-.54,-1.38,;-2.08,-1.38,;-2.98,-.13,;-4.45,-.61,;-4.45,-2.15,;-5.78,-2.92,;-7.11,-2.15,;-7.11,-.61,;-8.45,.16,;-9.78,-.61,;-9.78,-2.15,;-11.12,-2.92,;-8.45,-2.92,;-2.98,-2.62,;2.54,-1.38,;1.77,-2.71,;2.54,-4.05,;4.08,-4.05,;4.85,-2.71,;4.08,-1.38,)|
Show InChI InChI=1S/C25H23ClFN7O4/c1-37-16-9-17(38-2)21(27)19(20(16)26)14-3-4-15(23-22(14)29-5-6-30-23)24(36)33-25-31-10-13(32-25)11-34-8-7-28-18(35)12-34/h3-6,9-10H,7-8,11-12H2,1-2H3,(H,28,35)(H2,31,32,33,36)
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n/an/a 12n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102533
PNG
(US8536175, 122)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2nc(C)c(C)nc12 |(10.39,-2,;8.85,-2,;8.08,-.67,;8.85,.67,;8.08,2,;8.85,3.33,;8.08,4.67,;6.54,2,;5.78,3.33,;5.78,.67,;6.54,-.67,;5.78,-2,;4.23,.67,;3.47,2,;1.93,2,;1.15,.67,;-.38,.67,;-1.15,2,;-1.15,-.67,;-2.69,-.67,;-3.47,.67,;-5,.67,;-5.78,-.67,;-7.31,-.67,;-8.08,.67,;-7.31,2,;-8.08,3.33,;-9.63,3.33,;-10.39,4.67,;-10.39,2,;-9.63,.67,;-5,-2,;-3.47,-2,;1.93,-.67,;1.15,-2,;1.93,-3.33,;1.15,-4.67,;3.47,-3.33,;4.23,-4.67,;4.23,-2,;3.47,-.67,)|
Show InChI InChI=1S/C30H32Cl2N6O3/c1-17-18(2)35-29-21(30(39)36-24-9-6-19(15-33-24)16-38-12-10-37(3)11-13-38)8-7-20(28(29)34-17)25-26(31)22(40-4)14-23(41-5)27(25)32/h6-9,14-15H,10-13,16H2,1-5H3,(H,33,36,39)
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n/an/a 14n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102533
PNG
(US8536175, 122)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2nc(C)c(C)nc12 |(10.39,-2,;8.85,-2,;8.08,-.67,;8.85,.67,;8.08,2,;8.85,3.33,;8.08,4.67,;6.54,2,;5.78,3.33,;5.78,.67,;6.54,-.67,;5.78,-2,;4.23,.67,;3.47,2,;1.93,2,;1.15,.67,;-.38,.67,;-1.15,2,;-1.15,-.67,;-2.69,-.67,;-3.47,.67,;-5,.67,;-5.78,-.67,;-7.31,-.67,;-8.08,.67,;-7.31,2,;-8.08,3.33,;-9.63,3.33,;-10.39,4.67,;-10.39,2,;-9.63,.67,;-5,-2,;-3.47,-2,;1.93,-.67,;1.15,-2,;1.93,-3.33,;1.15,-4.67,;3.47,-3.33,;4.23,-4.67,;4.23,-2,;3.47,-.67,)|
Show InChI InChI=1S/C30H32Cl2N6O3/c1-17-18(2)35-29-21(30(39)36-24-9-6-19(15-33-24)16-38-12-10-37(3)11-13-38)8-7-20(28(29)34-17)25-26(31)22(40-4)14-23(41-5)27(25)32/h6-9,14-15H,10-13,16H2,1-5H3,(H,33,36,39)
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n/an/a 14n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102548
PNG
(US8536175, 174)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2ncccc12 |(10.39,-2.67,;8.85,-2.67,;8.08,-1.34,;8.85,-.01,;8.08,1.33,;8.85,2.66,;8.08,3.99,;6.54,1.33,;5.77,2.66,;5.77,-.01,;6.54,-1.34,;5.77,-2.67,;4.23,-.01,;3.46,1.33,;1.92,1.33,;1.15,-.01,;-.39,-.01,;-1.16,1.33,;-1.16,-1.34,;-2.7,-1.34,;-3.47,-.01,;-5.01,-.01,;-5.78,-1.34,;-7.32,-1.34,;-8.09,-.01,;-7.32,1.33,;-8.09,2.66,;-9.63,2.66,;-10.4,3.99,;-10.4,1.33,;-9.63,-.01,;-5.01,-2.67,;-3.47,-2.67,;1.92,-1.34,;1.15,-2.67,;1.92,-4.01,;3.46,-4.01,;4.23,-2.67,;3.46,-1.34,)|
Show InChI InChI=1S/C29H29F2N5O3/c1-35-11-13-36(14-12-35)17-18-6-9-24(33-16-18)34-29(37)21-8-7-19(20-5-4-10-32-28(20)21)25-26(30)22(38-2)15-23(39-3)27(25)31/h4-10,15-16H,11-14,17H2,1-3H3,(H,33,34,37)
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n/an/a 16n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM130077
PNG
(US8815901, 127)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2nccnc12 |(7.42,4,;8.19,2.67,;7.42,1.33,;8.19,,;7.42,-1.33,;8.19,-2.67,;9.73,-2.67,;5.88,-1.33,;5.11,-2.67,;5.11,,;5.88,1.33,;5.11,2.67,;3.57,,;2.8,1.33,;1.26,1.33,;.49,,;-1.05,,;-1.82,1.33,;-1.82,-1.33,;-3.36,-1.33,;-4.26,-.09,;-5.73,-.56,;-5.73,-2.1,;-7.06,-2.87,;-8.4,-2.1,;-8.4,-.56,;-9.73,-2.87,;-4.26,-2.58,;1.26,-1.33,;.49,-2.67,;1.26,-4,;2.8,-4,;3.57,-2.67,;2.8,-1.33,)|
Show InChI InChI=1S/C23H22F2N6O3/c1-31(2)11-12-10-28-23(29-12)30-22(32)14-6-5-13(20-21(14)27-8-7-26-20)17-18(24)15(33-3)9-16(34-4)19(17)25/h5-10H,11H2,1-4H3,(H2,28,29,30,32)
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n/an/a 16n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM130068
PNG
(US8815901, 20)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ncc(CN3CCN(C)CC3)[nH]2)c2nccnc12 |(10.91,-2.76,;9.37,-2.76,;8.6,-1.43,;9.37,-.1,;8.6,1.24,;9.37,2.57,;8.6,3.91,;7.06,1.24,;6.29,2.57,;6.29,-.1,;7.06,-1.43,;6.29,-2.76,;4.75,-.1,;3.98,1.24,;2.44,1.24,;1.67,-.1,;.13,-.1,;-.64,1.24,;-.64,-1.43,;-2.18,-1.43,;-3.09,-.18,;-4.55,-.66,;-4.55,-2.2,;-5.8,-3.1,;-7.13,-2.33,;-7.13,-.79,;-8.46,-.02,;-9.8,-.79,;-11.13,-.02,;-9.8,-2.33,;-8.46,-3.1,;-3.09,-2.67,;2.44,-1.43,;1.67,-2.76,;2.44,-4.1,;3.98,-4.1,;4.75,-2.76,;3.98,-1.43,)|
Show InChI InChI=1S/C26H27Cl2N7O3/c1-34-8-10-35(11-9-34)14-15-13-31-26(32-15)33-25(36)17-5-4-16(23-24(17)30-7-6-29-23)20-21(27)18(37-2)12-19(38-3)22(20)28/h4-7,12-13H,8-11,14H2,1-3H3,(H2,31,32,33,36)
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n/an/a 16n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102548
PNG
(US8536175, 174)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2ncccc12 |(10.39,-2.67,;8.85,-2.67,;8.08,-1.34,;8.85,-.01,;8.08,1.33,;8.85,2.66,;8.08,3.99,;6.54,1.33,;5.77,2.66,;5.77,-.01,;6.54,-1.34,;5.77,-2.67,;4.23,-.01,;3.46,1.33,;1.92,1.33,;1.15,-.01,;-.39,-.01,;-1.16,1.33,;-1.16,-1.34,;-2.7,-1.34,;-3.47,-.01,;-5.01,-.01,;-5.78,-1.34,;-7.32,-1.34,;-8.09,-.01,;-7.32,1.33,;-8.09,2.66,;-9.63,2.66,;-10.4,3.99,;-10.4,1.33,;-9.63,-.01,;-5.01,-2.67,;-3.47,-2.67,;1.92,-1.34,;1.15,-2.67,;1.92,-4.01,;3.46,-4.01,;4.23,-2.67,;3.46,-1.34,)|
Show InChI InChI=1S/C29H29F2N5O3/c1-35-11-13-36(14-12-35)17-18-6-9-24(33-16-18)34-29(37)21-8-7-19(20-5-4-10-32-28(20)21)25-26(30)22(38-2)15-23(39-3)27(25)31/h4-10,15-16H,11-14,17H2,1-3H3,(H,33,34,37)
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Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102535
PNG
(US8536175, 127)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2nccnc12 |(9.73,-2.67,;8.19,-2.67,;7.42,-1.33,;8.19,,;7.42,1.33,;8.19,2.67,;7.42,4,;5.88,1.33,;5.11,2.67,;5.11,,;5.88,-1.33,;5.11,-2.67,;3.57,,;2.8,1.33,;1.26,1.33,;.49,,;-1.05,,;-1.82,1.33,;-1.82,-1.33,;-3.36,-1.33,;-4.26,-.09,;-5.73,-.56,;-5.73,-2.1,;-7.06,-2.87,;-8.4,-2.1,;-9.73,-2.87,;-8.4,-.56,;-4.26,-2.58,;1.26,-1.33,;.49,-2.67,;1.26,-4,;2.8,-4,;3.57,-2.67,;2.8,-1.33,)|
Show InChI InChI=1S/C23H22F2N6O3/c1-31(2)11-12-10-28-23(29-12)30-22(32)14-6-5-13(20-21(14)27-8-7-26-20)17-18(24)15(33-3)9-16(34-4)19(17)25/h5-10H,11H2,1-4H3,(H2,28,29,30,32)
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n/an/a 16n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102508
PNG
(US8536175, 20)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ncc(CN3CCN(C)CC3)[nH]2)c2nccnc12 |(11.06,-2.67,;9.52,-2.67,;8.75,-1.33,;9.52,,;8.75,1.33,;9.52,2.67,;8.75,4,;7.21,1.33,;6.44,2.67,;6.44,,;7.21,-1.33,;6.44,-2.67,;4.9,,;4.13,1.33,;2.59,1.33,;1.82,,;.28,,;-.49,1.33,;-.49,-1.33,;-2.03,-1.33,;-2.93,-.09,;-4.4,-.56,;-4.4,-2.1,;-5.73,-2.87,;-7.06,-2.1,;-7.06,-.56,;-8.4,.21,;-9.73,-.56,;-11.06,.21,;-9.73,-2.1,;-8.4,-2.87,;-2.93,-2.58,;2.59,-1.33,;1.82,-2.67,;2.59,-4,;4.13,-4,;4.9,-2.67,;4.13,-1.33,)|
Show InChI InChI=1S/C26H27Cl2N7O3/c1-34-8-10-35(11-9-34)14-15-13-31-26(32-15)33-25(36)17-5-4-16(23-24(17)30-7-6-29-23)20-21(27)18(37-2)12-19(38-3)22(20)28/h4-7,12-13H,8-11,14H2,1-3H3,(H2,31,32,33,36)
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Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102531
PNG
(US8536175, 106)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(CCO)CC3)cn2)c2nccnc12 |(11.55,2.62,;10.01,2.62,;9.24,1.28,;10.01,-.05,;9.24,-1.38,;10.01,-2.72,;11.55,-2.72,;7.7,-1.38,;6.93,-2.72,;6.93,-.05,;7.7,1.28,;6.93,2.61,;5.39,-.05,;4.62,1.28,;3.08,1.28,;2.31,-.05,;.77,-.05,;0,1.28,;0,-1.38,;-1.54,-1.38,;-2.31,-.05,;-3.85,-.05,;-4.62,-1.38,;-6.16,-1.38,;-6.93,-.05,;-6.16,1.28,;-6.93,2.62,;-8.47,2.62,;-9.24,3.95,;-10.78,3.95,;-11.55,2.62,;-9.24,1.28,;-8.47,-.05,;-3.85,-2.72,;-2.31,-2.72,;3.08,-1.38,;2.31,-2.72,;3.08,-4.05,;4.62,-4.05,;5.39,-2.72,;4.62,-1.38,)|
Show InChI InChI=1S/C29H30Cl2N6O4/c1-40-21-15-22(41-2)26(31)24(25(21)30)19-4-5-20(28-27(19)32-7-8-33-28)29(39)35-23-6-3-18(16-34-23)17-37-11-9-36(10-12-37)13-14-38/h3-8,15-16,38H,9-14,17H2,1-2H3,(H,34,35,39)
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Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102531
PNG
(US8536175, 106)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(CCO)CC3)cn2)c2nccnc12 |(11.55,2.62,;10.01,2.62,;9.24,1.28,;10.01,-.05,;9.24,-1.38,;10.01,-2.72,;11.55,-2.72,;7.7,-1.38,;6.93,-2.72,;6.93,-.05,;7.7,1.28,;6.93,2.61,;5.39,-.05,;4.62,1.28,;3.08,1.28,;2.31,-.05,;.77,-.05,;0,1.28,;0,-1.38,;-1.54,-1.38,;-2.31,-.05,;-3.85,-.05,;-4.62,-1.38,;-6.16,-1.38,;-6.93,-.05,;-6.16,1.28,;-6.93,2.62,;-8.47,2.62,;-9.24,3.95,;-10.78,3.95,;-11.55,2.62,;-9.24,1.28,;-8.47,-.05,;-3.85,-2.72,;-2.31,-2.72,;3.08,-1.38,;2.31,-2.72,;3.08,-4.05,;4.62,-4.05,;5.39,-2.72,;4.62,-1.38,)|
Show InChI InChI=1S/C29H30Cl2N6O4/c1-40-21-15-22(41-2)26(31)24(25(21)30)19-4-5-20(28-27(19)32-7-8-33-28)29(39)35-23-6-3-18(16-34-23)17-37-11-9-36(10-12-37)13-14-38/h3-8,15-16,38H,9-14,17H2,1-2H3,(H,34,35,39)
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Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102512
PNG
(US8536175, 31)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2nccnc12 |(10.38,-2.67,;8.84,-2.67,;8.07,-1.33,;8.84,,;8.07,1.33,;8.84,2.67,;8.07,4,;6.53,1.33,;5.76,2.67,;5.76,,;6.53,-1.33,;5.76,-2.67,;4.22,,;3.45,1.33,;1.91,1.33,;1.14,,;-.4,,;-1.17,1.33,;-1.17,-1.33,;-2.71,-1.33,;-3.48,,;-5.02,,;-5.79,-1.33,;-7.33,-1.33,;-8.1,,;-7.33,1.33,;-8.08,2.65,;-9.61,2.65,;-10.38,3.98,;-10.36,1.33,;-9.64,,;-5.02,-2.67,;-3.48,-2.67,;1.91,-1.33,;1.14,-2.67,;1.91,-4,;3.45,-4,;4.22,-2.67,;3.45,-1.33,)|
Show InChI InChI=1S/C28H28Cl2N6O3/c1-35-10-12-36(13-11-35)16-17-4-7-22(33-15-17)34-28(37)19-6-5-18(26-27(19)32-9-8-31-26)23-24(29)20(38-2)14-21(39-3)25(23)30/h4-9,14-15H,10-13,16H2,1-3H3,(H,33,34,37)
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Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102512
PNG
(US8536175, 31)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2nccnc12 |(10.38,-2.67,;8.84,-2.67,;8.07,-1.33,;8.84,,;8.07,1.33,;8.84,2.67,;8.07,4,;6.53,1.33,;5.76,2.67,;5.76,,;6.53,-1.33,;5.76,-2.67,;4.22,,;3.45,1.33,;1.91,1.33,;1.14,,;-.4,,;-1.17,1.33,;-1.17,-1.33,;-2.71,-1.33,;-3.48,,;-5.02,,;-5.79,-1.33,;-7.33,-1.33,;-8.1,,;-7.33,1.33,;-8.08,2.65,;-9.61,2.65,;-10.38,3.98,;-10.36,1.33,;-9.64,,;-5.02,-2.67,;-3.48,-2.67,;1.91,-1.33,;1.14,-2.67,;1.91,-4,;3.45,-4,;4.22,-2.67,;3.45,-1.33,)|
Show InChI InChI=1S/C28H28Cl2N6O3/c1-35-10-12-36(13-11-35)16-17-4-7-22(33-15-17)34-28(37)19-6-5-18(26-27(19)32-9-8-31-26)23-24(29)20(38-2)14-21(39-3)25(23)30/h4-9,14-15H,10-13,16H2,1-3H3,(H,33,34,37)
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Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102506
PNG
(US8536175, 11)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(CC3)C(C)C)cc2)c2nccnc12 |(11.17,2,;9.63,2,;8.86,.67,;9.63,-.67,;8.86,-2,;9.63,-3.33,;11.17,-3.33,;7.32,-2,;6.54,-3.33,;6.54,-.67,;7.32,.67,;6.54,2,;5.01,-.67,;4.24,.67,;2.7,.67,;1.93,-.67,;.38,-.67,;-.38,.67,;-.38,-2,;-1.93,-2,;-2.7,-.67,;-4.24,-.67,;-5.01,-2,;-6.54,-2,;-7.32,-.67,;-6.54,.67,;-7.32,2,;-8.86,2,;-9.63,.67,;-8.86,-.67,;-9.63,3.33,;-11.17,3.33,;-8.86,4.67,;-4.24,-3.33,;-2.7,-3.33,;2.7,-2,;1.93,-3.33,;2.7,-4.67,;4.24,-4.67,;5.01,-3.33,;4.24,-2,)|
Show InChI InChI=1S/C31H33Cl2N5O3/c1-19(2)38-15-13-37(14-16-38)18-20-5-7-21(8-6-20)36-31(39)23-10-9-22(29-30(23)35-12-11-34-29)26-27(32)24(40-3)17-25(41-4)28(26)33/h5-12,17,19H,13-16,18H2,1-4H3,(H,36,39)
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n/an/a 31n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102506
PNG
(US8536175, 11)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(CC3)C(C)C)cc2)c2nccnc12 |(11.17,2,;9.63,2,;8.86,.67,;9.63,-.67,;8.86,-2,;9.63,-3.33,;11.17,-3.33,;7.32,-2,;6.54,-3.33,;6.54,-.67,;7.32,.67,;6.54,2,;5.01,-.67,;4.24,.67,;2.7,.67,;1.93,-.67,;.38,-.67,;-.38,.67,;-.38,-2,;-1.93,-2,;-2.7,-.67,;-4.24,-.67,;-5.01,-2,;-6.54,-2,;-7.32,-.67,;-6.54,.67,;-7.32,2,;-8.86,2,;-9.63,.67,;-8.86,-.67,;-9.63,3.33,;-11.17,3.33,;-8.86,4.67,;-4.24,-3.33,;-2.7,-3.33,;2.7,-2,;1.93,-3.33,;2.7,-4.67,;4.24,-4.67,;5.01,-3.33,;4.24,-2,)|
Show InChI InChI=1S/C31H33Cl2N5O3/c1-19(2)38-15-13-37(14-16-38)18-20-5-7-21(8-6-20)36-31(39)23-10-9-22(29-30(23)35-12-11-34-29)26-27(32)24(40-3)17-25(41-4)28(26)33/h5-12,17,19H,13-16,18H2,1-4H3,(H,36,39)
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Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102541
PNG
(US8536175, 152)
Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCS(=O)(=O)CC3)cn2)c2nccnc12 |(8.08,4,;8.85,2.67,;8.08,1.33,;8.85,,;8.08,-1.33,;8.85,-2.67,;10.39,-2.67,;6.54,-1.33,;5.77,-2.67,;5.77,,;6.54,1.33,;5.77,2.67,;4.23,,;3.46,1.33,;1.92,1.33,;1.15,,;-.39,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.46,,;-5,,;-5.77,-1.33,;-7.31,-1.33,;-8.08,,;-9.62,,;-10.39,1.33,;-9.62,2.67,;-10.39,4,;-8.85,4,;-8.08,2.67,;-7.31,1.33,;-5,-2.67,;-3.46,-2.67,;1.92,-1.33,;1.15,-2.67,;1.92,-4,;3.46,-4,;4.23,-2.67,;3.46,-1.33,)|
Show InChI InChI=1S/C27H25ClFN5O5S/c1-38-19-13-20(39-2)24(29)22(23(19)28)17-4-5-18(26-25(17)30-7-8-31-26)27(35)33-21-6-3-16(14-32-21)15-34-9-11-40(36,37)12-10-34/h3-8,13-14H,9-12,15H2,1-2H3,(H,32,33,35)
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n/an/a 32n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102541
PNG
(US8536175, 152)
Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCS(=O)(=O)CC3)cn2)c2nccnc12 |(8.08,4,;8.85,2.67,;8.08,1.33,;8.85,,;8.08,-1.33,;8.85,-2.67,;10.39,-2.67,;6.54,-1.33,;5.77,-2.67,;5.77,,;6.54,1.33,;5.77,2.67,;4.23,,;3.46,1.33,;1.92,1.33,;1.15,,;-.39,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.46,,;-5,,;-5.77,-1.33,;-7.31,-1.33,;-8.08,,;-9.62,,;-10.39,1.33,;-9.62,2.67,;-10.39,4,;-8.85,4,;-8.08,2.67,;-7.31,1.33,;-5,-2.67,;-3.46,-2.67,;1.92,-1.33,;1.15,-2.67,;1.92,-4,;3.46,-4,;4.23,-2.67,;3.46,-1.33,)|
Show InChI InChI=1S/C27H25ClFN5O5S/c1-38-19-13-20(39-2)24(29)22(23(19)28)17-4-5-18(26-25(17)30-7-8-31-26)27(35)33-21-6-3-16(14-32-21)15-34-9-11-40(36,37)12-10-34/h3-8,13-14H,9-12,15H2,1-2H3,(H,32,33,35)
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n/an/a 32n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102511
PNG
(US8536175, 25)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(cn2)C(=O)N2CCN(C)CC2)c2nccnc12 |(10.4,-2.67,;8.86,-2.67,;8.09,-1.33,;8.85,,;8.09,1.33,;8.86,2.67,;8.09,4,;6.55,1.33,;5.78,2.67,;5.78,,;6.55,-1.33,;5.78,-2.67,;4.23,,;3.47,1.33,;1.93,1.33,;1.15,,;-.38,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.47,,;-5,,;-5.78,-1.33,;-5,-2.67,;-3.47,-2.67,;-7.31,-1.33,;-8.08,-2.67,;-8.08,,;-7.31,1.33,;-8.08,2.67,;-9.63,2.67,;-10.39,4,;-10.39,1.33,;-9.63,,;1.93,-1.33,;1.15,-2.67,;1.93,-4,;3.47,-4,;4.23,-2.67,;3.47,-1.33,)|
Show InChI InChI=1S/C28H26Cl2N6O4/c1-35-10-12-36(13-11-35)28(38)16-4-7-21(33-15-16)34-27(37)18-6-5-17(25-26(18)32-9-8-31-25)22-23(29)19(39-2)14-20(40-3)24(22)30/h4-9,14-15H,10-13H2,1-3H3,(H,33,34,37)
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n/an/a 41n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102511
PNG
(US8536175, 25)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(cn2)C(=O)N2CCN(C)CC2)c2nccnc12 |(10.4,-2.67,;8.86,-2.67,;8.09,-1.33,;8.85,,;8.09,1.33,;8.86,2.67,;8.09,4,;6.55,1.33,;5.78,2.67,;5.78,,;6.55,-1.33,;5.78,-2.67,;4.23,,;3.47,1.33,;1.93,1.33,;1.15,,;-.38,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.47,,;-5,,;-5.78,-1.33,;-5,-2.67,;-3.47,-2.67,;-7.31,-1.33,;-8.08,-2.67,;-8.08,,;-7.31,1.33,;-8.08,2.67,;-9.63,2.67,;-10.39,4,;-10.39,1.33,;-9.63,,;1.93,-1.33,;1.15,-2.67,;1.93,-4,;3.47,-4,;4.23,-2.67,;3.47,-1.33,)|
Show InChI InChI=1S/C28H26Cl2N6O4/c1-35-10-12-36(13-11-35)28(38)16-4-7-21(33-15-16)34-27(37)18-6-5-17(25-26(18)32-9-8-31-25)22-23(29)19(39-2)14-20(40-3)24(22)30/h4-9,14-15H,10-13H2,1-3H3,(H,33,34,37)
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n/an/a 41n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Protein kinase activity measured by the microfluidic caliper method.


US Patent US8536175 (2013)


BindingDB Entry DOI: 10.7270/Q27D2SSH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM102527
PNG
(US8536175, 95)
Show SMILES CCN1CCN(Cc2ccc(NC(=O)c3ccc(-c4cc(OC)cc(OC)c4F)c4nccnc34)nc2)CC1
Show InChI InChI=1S/C29H31FN6O3/c1-4-35-11-13-36(14-12-35)18-19-5-8-25(33-17-19)34-29(37)22-7-6-21(27-28(22)32-10-9-31-27)23-15-20(38-2)16-24(39-3)26(23)30/h5-10,15-17H,4,11-14,18H2,1-3H3,(H,33,34,37)
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n/an/a 42n/an/an/an/an/a25



Novartis AG

US Patent


Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...


US Patent US8815901 (2014)


BindingDB Entry DOI: 10.7270/Q2XG9PT8
More data for this
Ligand-Target Pair
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