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Compile Data Set for Download or QSAR

Found 495 hits with Last Name = 'grigoriadis' and Initial = 'de'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM21397
PNG
(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29)
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0.0200n/an/an/an/an/an/an/an/a



NIDA Addiction Research Center

Curated by PDSP Ki Database




Life Sci 45: 1821-9 (1989)


Article DOI: 10.1016/0024-3205(89)90523-7
BindingDB Entry DOI: 10.7270/Q20Z71SN
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007518
PNG
((S)-3-chloro-5-ethyl-N-((1-ethylpyrrolidin-2-yl)me...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(CC)cc(Cl)c1OC
Show InChI InChI=1S/C17H25ClN2O3/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2/h9,12,21H,4-8,10H2,1-3H3,(H,19,22)/t12-/m0/s1
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0.0400n/an/an/an/an/an/an/an/a



NIDA Addiction Research Center

Curated by PDSP Ki Database




Life Sci 45: 1821-9 (1989)


Article DOI: 10.1016/0024-3205(89)90523-7
BindingDB Entry DOI: 10.7270/Q20Z71SN
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM81950
PNG
(CAS_130377 | NSC_130377 | Spectramide)
Show SMILES CNc1cc(OC)c(cc1Cl)C(=O)NCCN(C)Cc1ccc(I)cc1
Show InChI InChI=1S/C19H23ClIN3O2/c1-22-17-11-18(26-3)15(10-16(17)20)19(25)23-8-9-24(2)12-13-4-6-14(21)7-5-13/h4-7,10-11,22H,8-9,12H2,1-3H3,(H,23,25)
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0.130n/an/an/an/an/an/an/an/a



NIDA Addiction Research Center

Curated by PDSP Ki Database




Life Sci 45: 1821-9 (1989)


Article DOI: 10.1016/0024-3205(89)90523-7
BindingDB Entry DOI: 10.7270/Q20Z71SN
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM81950
PNG
(CAS_130377 | NSC_130377 | Spectramide)
Show SMILES CNc1cc(OC)c(cc1Cl)C(=O)NCCN(C)Cc1ccc(I)cc1
Show InChI InChI=1S/C19H23ClIN3O2/c1-22-17-11-18(26-3)15(10-16(17)20)19(25)23-8-9-24(2)12-13-4-6-14(21)7-5-13/h4-7,10-11,22H,8-9,12H2,1-3H3,(H,23,25)
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0.215n/an/an/an/an/an/an/an/a



NIDA Addiction Research Center

Curated by PDSP Ki Database




Life Sci 45: 1821-9 (1989)


Article DOI: 10.1016/0024-3205(89)90523-7
BindingDB Entry DOI: 10.7270/Q20Z71SN
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) alpha-1)


(Rattus norvegicus (Rat))
BDBM50001765
PNG
(8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]tri...)
Show SMILES Cc1nnc2CN=C(c3ccccc3Cl)c3cc(Cl)ccc3-n12 |t:6|
Show InChI InChI=1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3
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0.310n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 311: 537-46 (2004)


Article DOI: 10.1124/jpet.104.071282
BindingDB Entry DOI: 10.7270/Q2VH5MD8
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) alpha-1)


(Rattus norvegicus (Rat))
BDBM50001765
PNG
(8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]tri...)
Show SMILES Cc1nnc2CN=C(c3ccccc3Cl)c3cc(Cl)ccc3-n12 |t:6|
Show InChI InChI=1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3
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0.340n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 311: 537-46 (2004)


Article DOI: 10.1124/jpet.104.071282
BindingDB Entry DOI: 10.7270/Q2VH5MD8
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) alpha-1)


(Rattus norvegicus (Rat))
BDBM50001765
PNG
(8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]tri...)
Show SMILES Cc1nnc2CN=C(c3ccccc3Cl)c3cc(Cl)ccc3-n12 |t:6|
Show InChI InChI=1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3
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0.450n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 311: 537-46 (2004)


Article DOI: 10.1124/jpet.104.071282
BindingDB Entry DOI: 10.7270/Q2VH5MD8
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50132965
PNG
(CHEMBL115389 | Cyclopropylmethyl-[8-(2,4-dichloro-...)
Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(cccc12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H24Cl2N2/c1-3-11-27(14-16-7-8-16)22-12-15(2)26-23-19(5-4-6-20(22)23)18-10-9-17(24)13-21(18)25/h4-6,9-10,12-13,16H,3,7-8,11,14H2,1-2H3
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0.5n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human Corticotropin releasing factor receptor 1 expressed in CHO cells using [125I]-o-CRF as the radioligand


Bioorg Med Chem Lett 13: 3375-9 (2003)


BindingDB Entry DOI: 10.7270/Q2WM1CS4
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) alpha-1)


(Rattus norvegicus (Rat))
BDBM50001765
PNG
(8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]tri...)
Show SMILES Cc1nnc2CN=C(c3ccccc3Cl)c3cc(Cl)ccc3-n12 |t:6|
Show InChI InChI=1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3
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0.550n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 311: 537-46 (2004)


Article DOI: 10.1124/jpet.104.071282
BindingDB Entry DOI: 10.7270/Q2VH5MD8
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50132898
PNG
(CHEMBL115142 | Dibutyl-[3-(2,4-dichloro-phenyl)-1,...)
Show SMILES CCCCN(CCCC)c1cc(C)nc2c(nn(C)c12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C22H28Cl2N4/c1-5-7-11-28(12-8-6-2)19-13-15(3)25-21-20(26-27(4)22(19)21)17-10-9-16(23)14-18(17)24/h9-10,13-14H,5-8,11-12H2,1-4H3
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0.620n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the human corticotropin releasing factor receptor 1 expressed in HEK273 cells


Bioorg Med Chem Lett 13: 3367-70 (2003)


BindingDB Entry DOI: 10.7270/Q2542N05
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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0.650n/an/an/an/an/an/an/an/a



NIDA Addiction Research Center

Curated by PDSP Ki Database




Life Sci 45: 1821-9 (1989)


Article DOI: 10.1016/0024-3205(89)90523-7
BindingDB Entry DOI: 10.7270/Q20Z71SN
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50148897
PNG
(CHEMBL333735 | Cyclopropylmethyl-[3-(2,4-dichloro-...)
Show SMILES CCCN(CC1CC1)c1cc(SC)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl |(14.51,-6.15,;14.47,-7.69,;15.77,-8.49,;15.74,-10.02,;17.05,-10.83,;17.01,-12.37,;18.31,-13.17,;15.65,-13.1,;14.39,-10.76,;14.34,-12.3,;12.97,-13.05,;12.93,-14.57,;11.58,-15.31,;11.66,-12.23,;11.71,-10.68,;10.6,-9.61,;11.28,-8.23,;10.55,-6.87,;12.81,-8.44,;13.07,-9.96,;9.1,-9.88,;8.57,-11.33,;7.06,-11.6,;6.07,-10.42,;4.57,-10.7,;6.59,-8.98,;8.1,-8.7,;8.5,-7.21,)|
Show InChI InChI=1S/C21H24Cl2N4S/c1-4-9-26(12-14-5-6-14)19-11-18(28-3)24-21-20(13(2)25-27(19)21)16-8-7-15(22)10-17(16)23/h7-8,10-11,14H,4-6,9,12H2,1-3H3
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0.730n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the cloned human corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 14: 3669-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.019
BindingDB Entry DOI: 10.7270/Q2T72GWP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149670
PNG
(CHEMBL361782 | [3-(3-Chloro-5-trifluoromethyl-pyri...)
Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1Cl)C(F)(F)F |(3.73,6.08,;4.32,4.66,;3.39,3.42,;3.97,2,;5.49,1.81,;6.09,.37,;7.31,-.56,;5.89,-1.15,;3.04,.79,;3.62,-.64,;2.68,-1.85,;3.27,-3.27,;1.15,-1.64,;.59,-.22,;-.86,.27,;-.83,1.81,;-2.05,2.75,;.66,2.24,;1.52,.97,;-2.26,-.38,;-2.26,-1.94,;-3.59,-2.71,;-4.92,-1.94,;-4.92,-.4,;-3.59,.37,;-3.61,1.93,;-6.27,-2.71,;-7.48,-3.41,;-7.77,-2.13,;-6.53,-4.3,)|
Show InChI InChI=1S/C21H23ClF3N5/c1-4-7-29(11-14-5-6-14)17-8-12(2)27-20-18(13(3)28-30(17)20)19-16(22)9-15(10-26-19)21(23,24)25/h8-10,14H,4-7,11H2,1-3H3
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0.800n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for recombinant human CRF1 receptor


Bioorg Med Chem Lett 14: 3943-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.056
BindingDB Entry DOI: 10.7270/Q2KK9B7F
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50132951
PNG
(8-(2,4-dichlorophenyl)-2-methyl-N,N-dipropylquinol...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(cccc12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C22H24Cl2N2/c1-4-11-26(12-5-2)21-13-15(3)25-22-18(7-6-8-19(21)22)17-10-9-16(23)14-20(17)24/h6-10,13-14H,4-5,11-12H2,1-3H3
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0.900n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human CRF1 receptor expressed in CHO cells using [125I]-o-CRF as the radioligand


Bioorg Med Chem Lett 13: 3375-9 (2003)


BindingDB Entry DOI: 10.7270/Q2WM1CS4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50008735
PNG
((+)-3-(tert-butyl)-(3S,4aS,13bS)-2,3,4,4a,8,9,13b,...)
Show SMILES CC(C)(C)[C@]1(O)CCN2C[C@H]3c4ccccc4CCc4cccc([C@@H]2C1)c34
Show InChI InChI=1S/C25H31NO/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25/h4-10,21-22,27H,11-16H2,1-3H3/t21-,22-,25-/m0/s1
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0.970n/an/an/an/an/an/an/an/a



NIDA Addiction Research Center

Curated by PDSP Ki Database




Life Sci 45: 1821-9 (1989)


Article DOI: 10.1016/0024-3205(89)90523-7
BindingDB Entry DOI: 10.7270/Q20Z71SN
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM81195
PNG
((+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaph...)
Show SMILES NC1CCc2cc(O)c(O)cc2C1
Show InChI InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2
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1.07n/an/an/an/an/an/an/an/a



NIDA Addiction Research Center

Curated by PDSP Ki Database




Life Sci 45: 1821-9 (1989)


Article DOI: 10.1016/0024-3205(89)90523-7
BindingDB Entry DOI: 10.7270/Q20Z71SN
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171332
PNG
(1-(2-Bromo-4-isopropyl-phenyl)-7-methyl-5-(1-propy...)
Show SMILES CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccc(cc1Br)C(C)C)c2=O |(-5.8,2.54,;-4.46,3.31,;-3.13,2.54,;-1.79,3.31,;-1.78,4.86,;-.44,5.63,;-.44,7.18,;-.44,2.52,;.9,3.29,;2.23,2.52,;2.22,.97,;.89,.2,;-.44,.97,;-1.78,.19,;-1.78,-1.36,;-3.27,-1.8,;.08,-2.35,;1.22,-1.32,;2.76,-1.46,;3.73,-2.67,;3.16,-4.1,;4.14,-5.31,;5.66,-5.06,;6.2,-3.63,;5.25,-2.44,;5.81,-1.01,;6.41,-6.39,;5.64,-7.72,;7.96,-6.41,;3.37,-.05,;4.89,.27,)|
Show InChI InChI=1S/C25H33BrN4O/c1-6-8-19(9-7-2)28-12-13-29-23-22(28)14-17(5)27-24(23)30(25(29)31)21-11-10-18(16(3)4)15-20(21)26/h10-11,14-16,19H,6-9,12-13H2,1-5H3
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1.10n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149663
PNG
(CHEMBL183068 | Dibutyl-[3-(3-chloro-5-trifluoromet...)
Show SMILES CCCCN(CCCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1Cl)C(F)(F)F |(2.04,6.07,;3.58,5.86,;4.17,4.43,;3.23,3.22,;3.82,1.79,;5.35,1.58,;5.94,.16,;7.46,-.05,;8.07,-1.48,;2.88,.58,;3.47,-.85,;2.53,-2.06,;3.12,-3.49,;1.01,-1.88,;.43,-.45,;-1.02,.06,;-.97,1.6,;-2.2,2.54,;.5,2.02,;1.36,.76,;-2.42,-.62,;-2.42,-2.16,;-3.75,-2.93,;-5.09,-2.16,;-5.09,-.62,;-3.75,.16,;-3.76,1.7,;-6.42,-2.93,;-7.63,-3.63,;-7.94,-2.37,;-6.68,-4.52,)|
Show InChI InChI=1S/C22H27ClF3N5/c1-5-7-9-30(10-8-6-2)18-11-14(3)28-21-19(15(4)29-31(18)21)20-17(23)12-16(13-27-20)22(24,25)26/h11-13H,5-10H2,1-4H3
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1.10n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for recombinant human CRF1 receptor


Bioorg Med Chem Lett 14: 3943-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.056
BindingDB Entry DOI: 10.7270/Q2KK9B7F
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50087707
PNG
(CHEMBL295563 | [3-(2,4-Dimethoxy-phenyl)-2,5-dimet...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1OC |(17.03,-6.41,;17,-7.95,;15.62,-8.69,;15.6,-10.23,;16.9,-11.03,;16.86,-12.57,;18.17,-13.39,;14.25,-10.96,;14.19,-12.5,;12.82,-13.25,;12.78,-14.79,;11.51,-12.43,;11.56,-10.89,;10.45,-9.82,;11.12,-8.43,;10.4,-7.06,;12.65,-8.64,;12.92,-10.16,;8.95,-10.09,;8.42,-11.54,;6.9,-11.8,;5.91,-10.62,;4.4,-10.89,;3.89,-12.34,;6.44,-9.18,;7.95,-8.91,;8.48,-7.46,;7.48,-6.27,)|
Show InChI InChI=1S/C22H30N4O2/c1-7-11-25(12-8-2)20-13-15(3)23-22-21(16(4)24-26(20)22)18-10-9-17(27-5)14-19(18)28-6/h9-10,13-14H,7-8,11-12H2,1-6H3
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1.10n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the cloned human corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 14: 3669-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.019
BindingDB Entry DOI: 10.7270/Q2T72GWP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149654
PNG
(Butyl-[3-(3-chloro-5-trifluoromethyl-pyridin-2-yl)...)
Show SMILES CCCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1Cl)C(F)(F)F |(8.11,-1.27,;7.55,.16,;6.01,.37,;5.42,1.79,;3.89,1.99,;3.3,3.4,;4.24,4.64,;3.65,6.07,;2.95,.76,;3.54,-.66,;2.6,-1.88,;3.18,-3.3,;1.07,-1.67,;.5,-.24,;-.95,.25,;-.93,1.8,;-2.14,2.73,;.57,2.23,;1.45,.95,;-2.35,-.4,;-2.35,-1.97,;-3.68,-2.74,;-5.01,-1.97,;-5.01,-.43,;-3.68,.37,;-3.71,1.91,;-6.35,-2.74,;-7.58,-3.43,;-7.86,-2.16,;-6.63,-4.33,)|
Show InChI InChI=1S/C21H25ClF3N5/c1-5-7-9-29(8-6-2)17-10-13(3)27-20-18(14(4)28-30(17)20)19-16(22)11-15(12-26-19)21(23,24)25/h10-12H,5-9H2,1-4H3
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1.20n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for recombinant human CRF1 receptor


Bioorg Med Chem Lett 14: 3943-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.056
BindingDB Entry DOI: 10.7270/Q2KK9B7F
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) alpha-1)


(Rattus norvegicus (Rat))
BDBM86522
PNG
(CAS_325715-02-4 | Indiplon)
Show SMILES CN(C(C)=O)c1cccc(c1)-c1ccnc2c(cnn12)C(=O)c1cccs1
Show InChI InChI=1S/C20H16N4O2S/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18/h3-12H,1-2H3
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1.20n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 311: 537-46 (2004)


Article DOI: 10.1124/jpet.104.071282
BindingDB Entry DOI: 10.7270/Q2VH5MD8
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) alpha-1)


(Rattus norvegicus (Rat))
BDBM86522
PNG
(CAS_325715-02-4 | Indiplon)
Show SMILES CN(C(C)=O)c1cccc(c1)-c1ccnc2c(cnn12)C(=O)c1cccs1
Show InChI InChI=1S/C20H16N4O2S/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18/h3-12H,1-2H3
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1.20n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 311: 537-46 (2004)


Article DOI: 10.1124/jpet.104.071282
BindingDB Entry DOI: 10.7270/Q2VH5MD8
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149671
PNG
(CHEMBL362697 | [3-(3-Chloro-5-trifluoromethyl-pyri...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1Cl)C(F)(F)F |(3.94,6,;4.52,4.6,;3.59,3.37,;4.17,1.96,;5.71,1.73,;6.3,.3,;7.82,.11,;3.23,.72,;3.82,-.7,;2.88,-1.92,;3.47,-3.34,;1.36,-1.71,;.78,-.29,;-.67,.21,;-.63,1.77,;-1.85,2.7,;.85,2.19,;1.71,.91,;-2.07,-.47,;-2.07,-2.01,;-3.41,-2.78,;-4.74,-2.01,;-4.74,-.47,;-3.41,.3,;-3.41,1.85,;-6.08,-2.78,;-7.3,-3.47,;-7.59,-2.21,;-6.34,-4.37,)|
Show InChI InChI=1S/C20H23ClF3N5/c1-5-7-28(8-6-2)16-9-12(3)26-19-17(13(4)27-29(16)19)18-15(21)10-14(11-25-18)20(22,23)24/h9-11H,5-8H2,1-4H3
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1.20n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for recombinant human CRF1 receptor


Bioorg Med Chem Lett 14: 3943-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.056
BindingDB Entry DOI: 10.7270/Q2KK9B7F
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50152188
PNG
((4-Chloro-benzyl)-[3-(6-dimethylamino-4-methyl-pyr...)
Show SMILES CCN(Cc1ccc(Cl)cc1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.7,1.45,;4.67,.3,;3.17,.61,;2.68,2.07,;3.69,3.22,;3.2,4.68,;4.21,5.83,;5.75,5.52,;6.77,6.67,;6.23,4.05,;5.21,2.91,;2.15,-.54,;2.61,-1.99,;1.59,-3.15,;2.08,-4.6,;.1,-2.83,;-.39,-1.38,;-1.8,-.75,;-1.65,.79,;-2.8,1.8,;-.14,1.11,;.63,-.23,;-3.13,-1.52,;-3.13,-3.08,;-4.45,-3.85,;-5.79,-3.08,;-5.79,-1.54,;-4.45,-.75,;-4.46,.79,;-7.13,-3.85,;-8.46,-3.08,;-7.13,-5.39,)|
Show InChI InChI=1S/C25H29ClN6/c1-7-31(15-19-8-10-20(26)11-9-19)23-13-17(3)28-25-24(18(4)29-32(23)25)21-14-27-22(30(5)6)12-16(21)2/h8-14H,7,15H2,1-6H3
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1.30n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor


J Med Chem 47: 4787-98 (2004)


Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50148903
PNG
(CHEMBL413756 | [3-(3,4-Dimethoxy-phenyl)-2,5-dimet...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C22H30N4O2/c1-7-11-25(12-8-2)20-13-15(3)23-22-21(16(4)24-26(20)22)17-9-10-18(27-5)19(14-17)28-6/h9-10,13-14H,7-8,11-12H2,1-6H3
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1.30n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the cloned human corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 14: 3669-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.019
BindingDB Entry DOI: 10.7270/Q2T72GWP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071235
PNG
(CHEMBL65078 | Cyclopropylmethyl-[3-(2,4-dichloro-p...)
Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl |(17.18,-6.55,;17.15,-8.09,;15.79,-8.82,;15.75,-10.36,;17.06,-11.17,;17.01,-12.71,;18.31,-13.5,;15.65,-13.44,;14.4,-11.1,;14.35,-12.63,;12.98,-13.38,;12.93,-14.91,;11.67,-12.57,;11.72,-11.01,;10.61,-9.94,;11.28,-8.56,;10.55,-7.21,;12.81,-8.78,;13.09,-10.29,;9.11,-10.22,;8.1,-9.04,;6.59,-9.31,;6.08,-10.76,;4.57,-11.03,;7.07,-11.93,;8.59,-11.67,;9.57,-12.83,)|
Show InChI InChI=1S/C21H24Cl2N4/c1-4-9-26(12-15-5-6-15)19-10-13(2)24-21-20(14(3)25-27(19)21)17-8-7-16(22)11-18(17)23/h7-8,10-11,15H,4-6,9,12H2,1-3H3
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1.30n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the cloned human corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 14: 3669-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.019
BindingDB Entry DOI: 10.7270/Q2T72GWP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50148898
PNG
(CHEMBL333903 | [3-(4-Chloro-phenyl)-2,5-dimethyl-3...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H25ClN4/c1-5-11-24(12-6-2)18-13-14(3)22-20-19(15(4)23-25(18)20)16-7-9-17(21)10-8-16/h7-10,13H,5-6,11-12H2,1-4H3
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1.60n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the cloned human corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 14: 3669-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.019
BindingDB Entry DOI: 10.7270/Q2T72GWP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071235
PNG
(CHEMBL65078 | Cyclopropylmethyl-[3-(2,4-dichloro-p...)
Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl |(17.18,-6.55,;17.15,-8.09,;15.79,-8.82,;15.75,-10.36,;17.06,-11.17,;17.01,-12.71,;18.31,-13.5,;15.65,-13.44,;14.4,-11.1,;14.35,-12.63,;12.98,-13.38,;12.93,-14.91,;11.67,-12.57,;11.72,-11.01,;10.61,-9.94,;11.28,-8.56,;10.55,-7.21,;12.81,-8.78,;13.09,-10.29,;9.11,-10.22,;8.1,-9.04,;6.59,-9.31,;6.08,-10.76,;4.57,-11.03,;7.07,-11.93,;8.59,-11.67,;9.57,-12.83,)|
Show InChI InChI=1S/C21H24Cl2N4/c1-4-9-26(12-15-5-6-15)19-10-13(2)24-21-20(14(3)25-27(19)21)17-8-7-16(22)11-18(17)23/h7-8,10-11,15H,4-6,9,12H2,1-3H3
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1.60n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor


J Med Chem 47: 4787-98 (2004)


Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149657
PNG
(Benzyl-[3-(3-chloro-5-trifluoromethyl-pyridin-2-yl...)
Show SMILES CCCN(Cc1ccccc1)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1Cl)C(F)(F)F |(3.1,6.22,;3.69,4.78,;2.76,3.59,;3.34,2.16,;4.88,1.95,;5.46,.53,;4.51,-.68,;5.11,-2.12,;6.63,-2.32,;7.57,-1.08,;6.98,.34,;2.41,.93,;2.99,-.47,;2.05,-1.69,;2.64,-3.11,;.54,-1.5,;-.04,-.08,;-1.49,.44,;-1.46,1.98,;-2.66,2.91,;.03,2.4,;.89,1.12,;-2.89,-.26,;-2.89,-1.78,;-4.22,-2.55,;-5.55,-1.78,;-5.55,-.26,;-4.22,.53,;-4.22,2.05,;-6.88,-2.55,;-8.11,-3.25,;-8.4,-1.99,;-7.14,-4.14,)|
Show InChI InChI=1S/C24H23ClF3N5/c1-4-10-32(14-17-8-6-5-7-9-17)20-11-15(2)30-23-21(16(3)31-33(20)23)22-19(25)12-18(13-29-22)24(26,27)28/h5-9,11-13H,4,10,14H2,1-3H3
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1.70n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for recombinant human CRF1 receptor


Bioorg Med Chem Lett 14: 3943-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.056
BindingDB Entry DOI: 10.7270/Q2KK9B7F
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50132907
PNG
(CHEMBL112152 | Cyclopropylmethyl-[3-(2,4-dichloro-...)
Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(nn(CC)c12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C22H26Cl2N4/c1-4-10-27(13-15-6-7-15)19-11-14(3)25-21-20(26-28(5-2)22(19)21)17-9-8-16(23)12-18(17)24/h8-9,11-12,15H,4-7,10,13H2,1-3H3
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1.70n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the human corticotropin releasing factor receptor 1 expressed in HEK273 cells


Bioorg Med Chem Lett 13: 3367-70 (2003)


BindingDB Entry DOI: 10.7270/Q2542N05
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50132901
PNG
(CHEMBL445075 | Cyclopropylmethyl-[3-(2,4-dichloro-...)
Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(nn(C)c12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H24Cl2N4/c1-4-9-27(12-14-5-6-14)18-10-13(2)24-20-19(25-26(3)21(18)20)16-8-7-15(22)11-17(16)23/h7-8,10-11,14H,4-6,9,12H2,1-3H3
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1.70n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the human corticotropin releasing factor receptor 1 expressed in HEK273 cells


Bioorg Med Chem Lett 13: 3367-70 (2003)


BindingDB Entry DOI: 10.7270/Q2542N05
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054245
PNG
(5-Chloro-N-cyclopropylmethyl-2-methyl-N-propyl-N''...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Cl
Show InChI InChI=1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
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1.70n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) alpha-1)


(Rattus norvegicus (Rat))
BDBM86522
PNG
(CAS_325715-02-4 | Indiplon)
Show SMILES CN(C(C)=O)c1cccc(c1)-c1ccnc2c(cnn12)C(=O)c1cccs1
Show InChI InChI=1S/C20H16N4O2S/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18/h3-12H,1-2H3
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1.80n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 311: 537-46 (2004)


Article DOI: 10.1124/jpet.104.071282
BindingDB Entry DOI: 10.7270/Q2VH5MD8
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50148895
PNG
(Butyl-[3-(2,4-dimethoxy-phenyl)-2,5-dimethyl-3H-py...)
Show SMILES CCCCN(CC)c1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1OC |(18.13,-14.85,;18.17,-13.31,;16.86,-12.51,;16.91,-10.98,;15.58,-10.16,;15.63,-8.62,;14.32,-7.82,;14.24,-10.9,;14.19,-12.44,;12.82,-13.19,;12.78,-14.72,;11.5,-12.37,;11.55,-10.83,;10.45,-9.75,;11.12,-8.36,;10.39,-7.01,;12.65,-8.58,;12.92,-10.09,;8.94,-10.02,;8.42,-11.46,;6.91,-11.74,;5.9,-10.56,;4.4,-10.83,;3.88,-12.28,;6.44,-9.11,;7.95,-8.85,;8.48,-7.38,;7.49,-6.21,)|
Show InChI InChI=1S/C22H30N4O2/c1-7-9-12-25(8-2)20-13-15(3)23-22-21(16(4)24-26(20)22)18-11-10-17(27-5)14-19(18)28-6/h10-11,13-14H,7-9,12H2,1-6H3
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1.90n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the cloned human corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 14: 3669-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.019
BindingDB Entry DOI: 10.7270/Q2T72GWP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50132892
PNG
(Butyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-pyr...)
Show SMILES CCCCN(CC)c1cc(C)nc2c(nn(C)c12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C20H24Cl2N4/c1-5-7-10-26(6-2)17-11-13(3)23-19-18(24-25(4)20(17)19)15-9-8-14(21)12-16(15)22/h8-9,11-12H,5-7,10H2,1-4H3
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2n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the human corticotropin releasing factor receptor 1 expressed in HEK273 cells


Bioorg Med Chem Lett 13: 3367-70 (2003)


BindingDB Entry DOI: 10.7270/Q2542N05
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171318
PNG
(1-(4-Methoxy-phenyl)-7-methyl-5-(1-propyl-butyl)-4...)
Show SMILES CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccc(OC)cc1)c2=O
Show InChI InChI=1S/C23H30N4O2/c1-5-7-17(8-6-2)25-13-14-26-21-20(25)15-16(3)24-22(21)27(23(26)28)18-9-11-19(29-4)12-10-18/h9-12,15,17H,5-8,13-14H2,1-4H3
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2n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054245
PNG
(5-Chloro-N-cyclopropylmethyl-2-methyl-N-propyl-N''...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Cl
Show InChI InChI=1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
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2n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells


J Med Chem 48: 1540-9 (2005)


Article DOI: 10.1021/jm049339c
BindingDB Entry DOI: 10.7270/Q29P32DN
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054252
PNG
(5-Bromo-N-cyclopropylmethyl-2-methyl-N-propyl-N'-(...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Br
Show InChI InChI=1S/C18H20BrCl3N4/c1-3-6-26(9-11-4-5-11)18-15(19)17(23-10(2)24-18)25-16-13(21)7-12(20)8-14(16)22/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
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2n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50132902
PNG
(CHEMBL114861 | Dibutyl-[3-(2,4-dichloro-phenyl)-1-...)
Show SMILES CCCCN(CCCC)c1cc(C)nc2c(nn(CC)c12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H30Cl2N4/c1-5-8-12-28(13-9-6-2)20-14-16(4)26-22-21(27-29(7-3)23(20)22)18-11-10-17(24)15-19(18)25/h10-11,14-15H,5-9,12-13H2,1-4H3
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2.10n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the human corticotropin releasing factor receptor 1 expressed in HEK273 cells


Bioorg Med Chem Lett 13: 3367-70 (2003)


BindingDB Entry DOI: 10.7270/Q2542N05
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50152164
PNG
(CHEMBL366155 | [3-(6-Dimethylamino-2-methyl-pyridi...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ccc(nc1C)N(C)C |(3.88,5.71,;4.35,4.24,;3.34,3.1,;3.81,1.63,;5.33,1.32,;6.35,2.47,;7.85,2.16,;2.78,.48,;3.27,-.98,;2.25,-2.13,;2.73,-3.59,;.75,-1.8,;.26,-.36,;-1.14,.27,;-1,1.81,;-2.14,2.82,;.52,2.12,;1.29,.79,;-2.47,-.52,;-3.8,.26,;-5.13,-.52,;-5.13,-2.06,;-3.8,-2.83,;-2.47,-2.06,;-1.14,-2.83,;-6.48,-2.83,;-6.48,-4.37,;-7.81,-2.06,)|
Show InChI InChI=1S/C22H32N6/c1-8-12-27(13-9-2)20-14-15(3)23-22-21(17(5)25-28(20)22)18-10-11-19(26(6)7)24-16(18)4/h10-11,14H,8-9,12-13H2,1-7H3
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2.20n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor


J Med Chem 47: 4787-98 (2004)


Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50132973
PNG
(CHEMBL114596 | Cyclopropylmethyl-[2-methyl-8-(2,4,...)
Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(cccc12)-c1c(C)cc(C)cc1C |(9.34,3.42,;9.34,1.88,;8.01,1.11,;8.01,-.43,;9.36,-1.2,;9.36,-2.74,;8.03,-3.51,;10.69,-3.51,;6.68,-1.22,;6.68,-2.75,;5.34,-3.53,;5.34,-5.07,;4.01,-2.76,;4.01,-1.22,;2.68,-.45,;2.68,1.1,;4.01,1.87,;5.35,1.1,;5.35,-.45,;1.35,-1.22,;.01,-.44,;.02,1.1,;-1.32,-1.21,;-1.32,-2.75,;-2.65,-3.52,;.02,-3.52,;1.35,-2.75,;2.69,-3.52,)|
Show InChI InChI=1S/C26H32N2/c1-6-12-28(16-21-10-11-21)24-15-20(5)27-26-22(24)8-7-9-23(26)25-18(3)13-17(2)14-19(25)4/h7-9,13-15,21H,6,10-12,16H2,1-5H3
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2.20n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human Corticotropin releasing factor receptor 1 expressed in CHO cells using [125I]-o-CRF as the radioligand


Bioorg Med Chem Lett 13: 3375-9 (2003)


BindingDB Entry DOI: 10.7270/Q2WM1CS4
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50152183
PNG
(CHEMBL186033 | [3-(6-Dimethylamino-4-methyl-pyridi...)
Show SMILES CCN(Cc1ccc(C)cc1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.7,1.45,;4.67,.3,;3.17,.61,;2.68,2.07,;3.69,3.22,;3.2,4.68,;4.21,5.83,;5.75,5.52,;6.77,6.67,;6.23,4.05,;5.21,2.91,;2.15,-.54,;2.61,-1.99,;1.59,-3.15,;2.08,-4.6,;.1,-2.83,;-.39,-1.38,;-1.8,-.75,;-1.65,.79,;-2.8,1.8,;-.14,1.11,;.63,-.23,;-3.13,-1.52,;-3.13,-3.08,;-4.45,-3.85,;-5.79,-3.08,;-5.79,-1.54,;-4.45,-.75,;-4.46,.79,;-7.13,-3.85,;-8.46,-3.08,;-7.13,-5.39,)|
Show InChI InChI=1S/C26H32N6/c1-8-31(16-21-11-9-17(2)10-12-21)24-14-19(4)28-26-25(20(5)29-32(24)26)22-15-27-23(30(6)7)13-18(22)3/h9-15H,8,16H2,1-7H3
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2.30n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor


J Med Chem 47: 4787-98 (2004)


Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054250
PNG
(CHEMBL306482 | N-Cyclopropylmethyl-2,5-dimethyl-N-...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C
Show InChI InChI=1S/C19H23Cl3N4/c1-4-7-26(10-13-5-6-13)19-11(2)18(23-12(3)24-19)25-17-15(21)8-14(20)9-16(17)22/h8-9,13H,4-7,10H2,1-3H3,(H,23,24,25)
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2.30n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50148893
PNG
(CHEMBL332101 | Cyclopropylmethyl-[3-(4-methoxy-phe...)
Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1
Show InChI InChI=1S/C22H28N4O/c1-5-12-25(14-17-6-7-17)20-13-15(2)23-22-21(16(3)24-26(20)22)18-8-10-19(27-4)11-9-18/h8-11,13,17H,5-7,12,14H2,1-4H3
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2.40n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the cloned human corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 14: 3669-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.019
BindingDB Entry DOI: 10.7270/Q2T72GWP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50132961
PNG
(Butyl-ethyl-[2-methyl-8-(2,4,6-trimethyl-phenyl)-q...)
Show SMILES CCCCN(CC)c1cc(C)nc2c(cccc12)-c1c(C)cc(C)cc1C |(10.69,-5.05,;10.69,-3.51,;9.36,-2.74,;9.36,-1.2,;8.01,-.43,;8.01,1.11,;9.34,1.88,;6.68,-1.22,;6.68,-2.75,;5.34,-3.53,;5.34,-5.07,;4.01,-2.76,;4.01,-1.22,;2.68,-.45,;2.68,1.1,;4.01,1.87,;5.35,1.1,;5.35,-.45,;1.35,-1.22,;.01,-.44,;.02,1.1,;-1.32,-1.21,;-1.32,-2.75,;-2.65,-3.52,;.02,-3.52,;1.35,-2.75,;2.69,-3.52,)|
Show InChI InChI=1S/C25H32N2/c1-7-9-13-27(8-2)23-16-20(6)26-25-21(23)11-10-12-22(25)24-18(4)14-17(3)15-19(24)5/h10-12,14-16H,7-9,13H2,1-6H3
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2.40n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human Corticotropin releasing factor receptor 1 expressed in CHO cells using [125I]-o-CRF as the radioligand


Bioorg Med Chem Lett 13: 3375-9 (2003)


BindingDB Entry DOI: 10.7270/Q2WM1CS4
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50152178
PNG
(CHEMBL361509 | [3-(6-Dimethylamino-4-methyl-pyridi...)
Show SMILES CCN(Cc1ccccc1C)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.86,1.5,;4.84,.34,;3.33,.67,;2.85,2.13,;3.86,3.29,;5.37,2.96,;6.4,4.13,;5.91,5.58,;4.39,5.89,;3.37,4.74,;1.87,5.06,;2.3,-.49,;2.78,-1.94,;1.75,-3.09,;2.24,-4.56,;.26,-2.78,;-.23,-1.32,;-1.64,-.71,;-1.49,.84,;-2.64,1.86,;.02,1.16,;.79,-.17,;-2.97,-1.47,;-2.97,-3.02,;-4.3,-3.81,;-5.63,-3.02,;-5.63,-1.5,;-4.3,-.71,;-4.31,.84,;-6.98,-3.81,;-8.31,-3.02,;-6.98,-5.33,)|
Show InChI InChI=1S/C26H32N6/c1-8-31(16-21-12-10-9-11-17(21)2)24-14-19(4)28-26-25(20(5)29-32(24)26)22-15-27-23(30(6)7)13-18(22)3/h9-15H,8,16H2,1-7H3
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2.40n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor


J Med Chem 47: 4787-98 (2004)


Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50152179
PNG
(CHEMBL185705 | [3-(6-Dimethylamino-4-methyl-pyridi...)
Show SMILES CCN(Cc1cccc(C)c1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.79,1.42,;4.77,.27,;3.27,.6,;2.79,2.06,;3.81,3.22,;5.3,2.89,;6.34,4.04,;5.85,5.5,;4.33,5.81,;3.84,7.28,;3.32,4.67,;2.24,-.56,;2.72,-2.02,;1.68,-3.18,;2.18,-4.63,;.19,-2.86,;-.3,-1.4,;-1.7,-.78,;-1.54,.76,;-2.7,1.78,;-.04,1.09,;.73,-.26,;-3.03,-1.55,;-3.03,-3.09,;-4.36,-3.88,;-5.69,-3.09,;-5.69,-1.56,;-4.36,-.78,;-4.38,.76,;-7.03,-3.88,;-7.03,-5.42,;-8.36,-3.09,)|
Show InChI InChI=1S/C26H32N6/c1-8-31(16-21-11-9-10-17(2)12-21)24-14-19(4)28-26-25(20(5)29-32(24)26)22-15-27-23(30(6)7)13-18(22)3/h9-15H,8,16H2,1-7H3
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2.40n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor


J Med Chem 47: 4787-98 (2004)


Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50148887
PNG
(CHEMBL120823 | Cyclopropylmethyl-[3-(2,4-dimethoxy...)
Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1OC |(14.58,-6.56,;14.55,-8.11,;15.86,-8.9,;15.82,-10.44,;17.14,-11.26,;17.09,-12.79,;18.4,-13.59,;15.74,-13.52,;14.47,-11.19,;14.42,-12.73,;13.05,-13.48,;13.01,-15,;11.73,-12.65,;11.78,-11.11,;10.69,-10.04,;11.35,-8.64,;10.61,-7.28,;12.88,-8.86,;13.15,-10.37,;9.17,-10.3,;8.65,-11.75,;7.14,-12.03,;6.13,-10.83,;4.63,-11.12,;4.1,-12.56,;6.66,-9.39,;8.18,-9.12,;8.7,-7.66,;7.72,-6.5,)|
Show InChI InChI=1S/C23H30N4O2/c1-6-11-26(14-17-7-8-17)21-12-15(2)24-23-22(16(3)25-27(21)23)19-10-9-18(28-4)13-20(19)29-5/h9-10,12-13,17H,6-8,11,14H2,1-5H3
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2.40n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the cloned human corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 14: 3669-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.019
BindingDB Entry DOI: 10.7270/Q2T72GWP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054248
PNG
(2,5-Dimethyl-N,N-dipropyl-N'-(2,4,6-trichloro-phen...)
Show SMILES CCCN(CCC)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C
Show InChI InChI=1S/C18H23Cl3N4/c1-5-7-25(8-6-2)18-11(3)17(22-12(4)23-18)24-16-14(20)9-13(19)10-15(16)21/h9-10H,5-8H2,1-4H3,(H,22,23,24)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
2.5n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50283398
PNG
((1-Benzyl-piperidin-4-yl)-(3-phenyl-prop-2-ynyl)-a...)
Show SMILES C(NC1CCN(Cc2ccccc2)CC1)C#Cc1ccccc1
Show InChI InChI=1S/C21H24N2/c1-3-8-19(9-4-1)12-7-15-22-21-13-16-23(17-14-21)18-20-10-5-2-6-11-20/h1-6,8-11,21-22H,13-18H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
2.5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibiton of [3H]-(+)-SKF-10,047 binding to sigma receptor


Bioorg Med Chem Lett 4: 329-334 (1994)


Article DOI: 10.1016/S0960-894X(01)80138-4
BindingDB Entry DOI: 10.7270/Q20R9PBC
More data for this
Ligand-Target Pair
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