new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 109 hits with Last Name = 'gross' and Initial = 'mf'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM50212239
PNG
(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)
Show SMILES COc1cc(NC(=O)c2ccc(o2)-c2ccc(Cl)cc2)cc(OC)c1
Show InChI InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Nav 1.8 channel expressed in HEK293 cells


J Med Chem 51: 407-16 (2008)


Article DOI: 10.1021/jm070637u
BindingDB Entry DOI: 10.7270/Q2KK9CN7
More data for this
Ligand-Target Pair
Sodium channel protein type X alpha subunit


(Mus musculus)
BDBM50231774
PNG
(5-(4-chlorophenyl)-N-cyano-N'-(3-methylphenyl)fura...)
Show SMILES Cc1cccc(c1)N=C(NC#N)c1ccc(o1)-c1ccc(Cl)cc1 |w:7.7|
Show InChI InChI=1S/C19H14ClN3O/c1-13-3-2-4-16(11-13)23-19(22-12-21)18-10-9-17(24-18)14-5-7-15(20)8-6-14/h2-11H,1H3,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assay


J Med Chem 51: 407-16 (2008)


Article DOI: 10.1021/jm070637u
BindingDB Entry DOI: 10.7270/Q2KK9CN7
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM50270707
PNG
(CHEMBL486495 | [5-(4-tert-Butylphenyl)furan-2-yl]-...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccc(o1)C(=O)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C25H34N2O2/c1-25(2,3)20-11-9-19(10-12-20)22-13-14-23(29-22)24(28)27-17-15-26(16-18-27)21-7-5-4-6-8-21/h9-14,21H,4-8,15-18H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Nav1.8 channel expressed in HEK293 cells by whole cell voltage clamp technique


Bioorg Med Chem 16: 6379-86 (2008)


Article DOI: 10.1016/j.bmc.2008.05.003
BindingDB Entry DOI: 10.7270/Q2VH5NNT
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50099581
PNG
(CHEMBL288131 | N-((2R,3R)-3-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)Cc2ccc(NC(=O)c3cccc(OC)c3)cc12 |r|
Show InChI InChI=1S/C25H26N2O5S/c1-3-16-7-11-21(12-8-16)33(30,31)27-24-22-15-19(10-9-17(22)14-23(24)28)26-25(29)18-5-4-6-20(13-18)32-2/h4-13,15,23-24,27-28H,3,14H2,1-2H3,(H,26,29)/t23-,24-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Icagen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5 channel mediated delayed rectifier potassium current by patch-clamp technique


Bioorg Med Chem Lett 17: 2849-53 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.052
BindingDB Entry DOI: 10.7270/Q2VM4BZS
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258540
PNG
(CHEMBL468514 | N-((7R,8R)-7-hydroxy-8-(4-pentylphe...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)c3cccc(OC)c3)cc12 |r|
Show InChI InChI=1S/C29H34N2O5S/c1-3-4-5-7-20-10-15-25(16-11-20)37(34,35)31-28-26-19-23(14-12-21(26)13-17-27(28)32)30-29(33)22-8-6-9-24(18-22)36-2/h6,8-12,14-16,18-19,27-28,31-32H,3-5,7,13,17H2,1-2H3,(H,30,33)/t27-,28-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM50231767
PNG
(5-(4-cyanophenyl)-N-(3-methylphenyl)furan-2-carbox...)
Show SMILES Cc1cccc(NC(=O)c2ccc(o2)-c2ccc(cc2)C#N)c1
Show InChI InChI=1S/C19H14N2O2/c1-13-3-2-4-16(11-13)21-19(22)18-10-9-17(23-18)15-7-5-14(12-20)6-8-15/h2-11H,1H3,(H,21,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 79n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Nav 1.8 channel expressed in HEK293 cells


J Med Chem 51: 407-16 (2008)


Article DOI: 10.1021/jm070637u
BindingDB Entry DOI: 10.7270/Q2KK9CN7
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM50270707
PNG
(CHEMBL486495 | [5-(4-tert-Butylphenyl)furan-2-yl]-...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccc(o1)C(=O)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C25H34N2O2/c1-25(2,3)20-11-9-19(10-12-20)22-13-14-23(29-22)24(28)27-17-15-26(16-18-27)21-7-5-4-6-8-21/h9-14,21H,4-8,15-18H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 90n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current by whole cell patch clamp technique


Bioorg Med Chem 16: 6379-86 (2008)


Article DOI: 10.1016/j.bmc.2008.05.003
BindingDB Entry DOI: 10.7270/Q2VH5NNT
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258501
PNG
(CHEMBL466838 | N-((7R,8R)-7-hydroxy-8-(4-propylphe...)
Show SMILES CCCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)c3cccc(OC)c3)cc12 |r|
Show InChI InChI=1S/C27H30N2O5S/c1-3-5-18-8-13-23(14-9-18)35(32,33)29-26-24-17-21(12-10-19(24)11-15-25(26)30)28-27(31)20-6-4-7-22(16-20)34-2/h4,6-10,12-14,16-17,25-26,29-30H,3,5,11,15H2,1-2H3,(H,28,31)/t25-,26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 90n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50270707
PNG
(CHEMBL486495 | [5-(4-tert-Butylphenyl)furan-2-yl]-...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccc(o1)C(=O)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C25H34N2O2/c1-25(2,3)20-11-9-19(10-12-20)22-13-14-23(29-22)24(28)27-17-15-26(16-18-27)21-7-5-4-6-8-21/h9-14,21H,4-8,15-18H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Nav1.2 channel expressed in HEK293 cells by whole cell voltage clamp technique


Bioorg Med Chem 16: 6379-86 (2008)


Article DOI: 10.1016/j.bmc.2008.05.003
BindingDB Entry DOI: 10.7270/Q2VH5NNT
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50270707
PNG
(CHEMBL486495 | [5-(4-tert-Butylphenyl)furan-2-yl]-...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccc(o1)C(=O)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C25H34N2O2/c1-25(2,3)20-11-9-19(10-12-20)22-13-14-23(29-22)24(28)27-17-15-26(16-18-27)21-7-5-4-6-8-21/h9-14,21H,4-8,15-18H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Nav1.5 channel expressed in HEK293 cells by whole cell voltage clamp technique


Bioorg Med Chem 16: 6379-86 (2008)


Article DOI: 10.1016/j.bmc.2008.05.003
BindingDB Entry DOI: 10.7270/Q2VH5NNT
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50240481
PNG
(CHEMBL42934 | N-((7R,8R)-8-(4-butylphenylsulfonami...)
Show SMILES CCCCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)c3cccc(OC)c3)cc12 |r|
Show InChI InChI=1S/C28H32N2O5S/c1-3-4-6-19-9-14-24(15-10-19)36(33,34)30-27-25-18-22(13-11-20(25)12-16-26(27)31)29-28(32)21-7-5-8-23(17-21)35-2/h5,7-11,13-15,17-18,26-27,30-31H,3-4,6,12,16H2,1-2H3,(H,29,32)/t26-,27-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50207909
PNG
(CHEMBL239805 | N-(3-(4-ethylphenylsulfonamido)-2,3...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)NC1CCc2ccc(NC(=O)c3cccc(OC)c3)cc12 |w:12.12|
Show InChI InChI=1S/C25H26N2O4S/c1-3-17-7-12-22(13-8-17)32(29,30)27-24-14-10-18-9-11-20(16-23(18)24)26-25(28)19-5-4-6-21(15-19)31-2/h4-9,11-13,15-16,24,27H,3,10,14H2,1-2H3,(H,26,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Icagen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5 channel mediated delayed rectifier potassium current by patch-clamp technique


Bioorg Med Chem Lett 17: 2849-53 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.052
BindingDB Entry DOI: 10.7270/Q2VM4BZS
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50099581
PNG
(CHEMBL288131 | N-((2R,3R)-3-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)Cc2ccc(NC(=O)c3cccc(OC)c3)cc12 |r|
Show InChI InChI=1S/C25H26N2O5S/c1-3-16-7-11-21(12-8-16)33(30,31)27-24-22-15-19(10-9-17(22)14-23(24)28)26-25(29)18-5-4-6-20(13-18)32-2/h4-13,15,23-24,27-28H,3,14H2,1-2H3,(H,26,29)/t23-,24-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258503
PNG
(CHEMBL466019 | N-((7R,8R)-8-(4-tert-butylphenylsul...)
Show SMILES COc1cccc(c1)C(=O)Nc1ccc2CC[C@@H](O)[C@H](NS(=O)(=O)c3ccc(cc3)C(C)(C)C)c2c1 |r|
Show InChI InChI=1S/C28H32N2O5S/c1-28(2,3)20-10-13-23(14-11-20)36(33,34)30-26-24-17-21(12-8-18(24)9-15-25(26)31)29-27(32)19-6-5-7-22(16-19)35-4/h5-8,10-14,16-17,25-26,30-31H,9,15H2,1-4H3,(H,29,32)/t25-,26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50099581
PNG
(CHEMBL288131 | N-((2R,3R)-3-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)Cc2ccc(NC(=O)c3cccc(OC)c3)cc12 |r|
Show InChI InChI=1S/C25H26N2O5S/c1-3-16-7-11-21(12-8-16)33(30,31)27-24-22-15-19(10-9-17(22)14-23(24)28)26-25(29)18-5-4-6-20(13-18)32-2/h4-13,15,23-24,27-28H,3,14H2,1-2H3,(H,26,29)/t23-,24-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Icagen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5 channel mediated delayed rectifier potassium current by patch-clamp technique


Bioorg Med Chem Lett 17: 2849-53 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.052
BindingDB Entry DOI: 10.7270/Q2VM4BZS
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50207912
PNG
(CHEMBL239808 | N-((8R,9R)-9-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCCc2ccc(NC(=O)c3cccc(OC)c3)cc12
Show InChI InChI=1S/C27H30N2O5S/c1-3-18-10-14-23(15-11-18)35(32,33)29-26-24-17-21(13-12-19(24)6-5-9-25(26)30)28-27(31)20-7-4-8-22(16-20)34-2/h4,7-8,10-17,25-26,29-30H,3,5-6,9H2,1-2H3,(H,28,31)/t25-,26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Icagen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5 channel mediated delayed rectifier potassium current by patch-clamp technique


Bioorg Med Chem Lett 17: 2849-53 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.052
BindingDB Entry DOI: 10.7270/Q2VM4BZS
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258755
PNG
(CHEMBL467478 | N-((7R,8R)-8-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)\C=C\c3ccccc3)cc12 |r|
Show InChI InChI=1S/C27H28N2O4S/c1-2-19-8-14-23(15-9-19)34(32,33)29-27-24-18-22(13-11-21(24)12-16-25(27)30)28-26(31)17-10-20-6-4-3-5-7-20/h3-11,13-15,17-18,25,27,29-30H,2,12,16H2,1H3,(H,28,31)/b17-10+/t25-,27-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258410
PNG
((R)-1-(3-chlorobenzyl)-N-((7R,8R)-8-(4-ethylphenyl...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)[C@H]3CCCN3Cc3cccc(Cl)c3)cc12 |r|
Show InChI InChI=1S/C30H34ClN3O4S/c1-2-20-8-13-25(14-9-20)39(37,38)33-29-26-18-24(12-10-22(26)11-15-28(29)35)32-30(36)27-7-4-16-34(27)19-21-5-3-6-23(31)17-21/h3,5-6,8-10,12-14,17-18,27-29,33,35H,2,4,7,11,15-16,19H2,1H3,(H,32,36)/t27-,28-,29-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 220n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258758
PNG
(CHEMBL466646 | benzyl (7R,8R)-8-(4-ethylphenylsulf...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)OCc3ccccc3)cc12 |r|
Show InChI InChI=1S/C26H28N2O5S/c1-2-18-8-13-22(14-9-18)34(31,32)28-25-23-16-21(12-10-20(23)11-15-24(25)29)27-26(30)33-17-19-6-4-3-5-7-19/h3-10,12-14,16,24-25,28-29H,2,11,15,17H2,1H3,(H,27,30)/t24-,25-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 230n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50207906
PNG
(CHEMBL241513 | N-(3-((4-ethylphenylsulfonamido)met...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)NCc1cccc(NC(=O)c2cccc(OC)c2)c1
Show InChI InChI=1S/C23H24N2O4S/c1-3-17-10-12-22(13-11-17)30(27,28)24-16-18-6-4-8-20(14-18)25-23(26)19-7-5-9-21(15-19)29-2/h4-15,24H,3,16H2,1-2H3,(H,25,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 240n/an/an/an/an/an/a



Icagen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5 channel mediated delayed rectifier potassium current by patch-clamp technique


Bioorg Med Chem Lett 17: 2849-53 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.052
BindingDB Entry DOI: 10.7270/Q2VM4BZS
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258728
PNG
(CHEMBL466224 | N-((7R,8R)-8-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)CCc3ccccc3)cc12 |r|
Show InChI InChI=1S/C27H30N2O4S/c1-2-19-8-14-23(15-9-19)34(32,33)29-27-24-18-22(13-11-21(24)12-16-25(27)30)28-26(31)17-10-20-6-4-3-5-7-20/h3-9,11,13-15,18,25,27,29-30H,2,10,12,16-17H2,1H3,(H,28,31)/t25-,27-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM50270649
PNG
(1-[5-(4-Chlorophenyl)-2-furoyl]piperazine | CHEMBL...)
Show SMILES Clc1ccc(cc1)-c1ccc(o1)C(=O)N1CCNCC1
Show InChI InChI=1S/C15H15ClN2O2/c16-12-3-1-11(2-4-12)13-5-6-14(20-13)15(19)18-9-7-17-8-10-18/h1-6,17H,7-10H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 280n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Nav1.8 channel expressed in HEK293 cells by whole cell voltage clamp technique


Bioorg Med Chem 16: 6379-86 (2008)


Article DOI: 10.1016/j.bmc.2008.05.003
BindingDB Entry DOI: 10.7270/Q2VH5NNT
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258801
PNG
((S)-N-(8-(4-ethylphenylsulfonamido)-5,6,7,8-tetrah...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1CCCc2ccc(NC(=O)CCc3ccccc3)cc12 |r|
Show InChI InChI=1S/C27H30N2O3S/c1-2-20-11-16-24(17-12-20)33(31,32)29-26-10-6-9-22-14-15-23(19-25(22)26)28-27(30)18-13-21-7-4-3-5-8-21/h3-5,7-8,11-12,14-17,19,26,29H,2,6,9-10,13,18H2,1H3,(H,28,30)/t26-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 280n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258411
PNG
((R)-N-((7R,8R)-8-(4-ethylphenylsulfonamido)-7-hydr...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)[C@H]3CCCN3Cc3cccc(OC(F)(F)F)c3)cc12 |r|
Show InChI InChI=1S/C31H34F3N3O5S/c1-2-20-8-13-25(14-9-20)43(40,41)36-29-26-18-23(12-10-22(26)11-15-28(29)38)35-30(39)27-7-4-16-37(27)19-21-5-3-6-24(17-21)42-31(32,33)34/h3,5-6,8-10,12-14,17-18,27-29,36,38H,2,4,7,11,15-16,19H2,1H3,(H,35,39)/t27-,28-,29-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 290n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Sodium channel protein type X alpha subunit


(Mus musculus)
BDBM50231777
PNG
(5-[(4-trifluoromethoxy)phenyl]-N-(3-methylphenyl)f...)
Show SMILES Cc1cccc(NC(=O)c2ccc(o2)-c2ccc(OC(F)(F)F)cc2)c1
Show InChI InChI=1S/C19H14F3NO3/c1-12-3-2-4-14(11-12)23-18(24)17-10-9-16(25-17)13-5-7-15(8-6-13)26-19(20,21)22/h2-11H,1H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 290n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assay


J Med Chem 51: 407-16 (2008)


Article DOI: 10.1021/jm070637u
BindingDB Entry DOI: 10.7270/Q2KK9CN7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258412
PNG
((R)-N-((7R,8R)-8-(4-ethylphenylsulfonamido)-7-hydr...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)[C@H]3CCCN3Cc3cccc(OC)c3)cc12 |r|
Show InChI InChI=1S/C31H37N3O5S/c1-3-21-9-14-26(15-10-21)40(37,38)33-30-27-19-24(13-11-23(27)12-16-29(30)35)32-31(36)28-8-5-17-34(28)20-22-6-4-7-25(18-22)39-2/h4,6-7,9-11,13-15,18-19,28-30,33,35H,3,5,8,12,16-17,20H2,1-2H3,(H,32,36)/t28-,29-,30-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM50270679
PNG
(CHEMBL482676 | [5-(4-Chlorophenyl)furan-2-yl]-(4-c...)
Show SMILES Clc1ccc(cc1)-c1ccc(o1)C(=O)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H25ClN2O2/c22-17-8-6-16(7-9-17)19-10-11-20(26-19)21(25)24-14-12-23(13-15-24)18-4-2-1-3-5-18/h6-11,18H,1-5,12-15H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Nav1.8 channel expressed in HEK293 cells by whole cell voltage clamp technique


Bioorg Med Chem 16: 6379-86 (2008)


Article DOI: 10.1016/j.bmc.2008.05.003
BindingDB Entry DOI: 10.7270/Q2VH5NNT
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50207911
PNG
(CHEMBL398397 | N-((2S,3R)-3-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@@H](O)Cc2ccc(NC(=O)c3cccc(OC)c3)cc12
Show InChI InChI=1S/C25H26N2O5S/c1-3-16-7-11-21(12-8-16)33(30,31)27-24-22-15-19(10-9-17(22)14-23(24)28)26-25(29)18-5-4-6-20(13-18)32-2/h4-13,15,23-24,27-28H,3,14H2,1-2H3,(H,26,29)/t23-,24+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Icagen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5 channel mediated delayed rectifier potassium current by patch-clamp technique


Bioorg Med Chem Lett 17: 2849-53 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.052
BindingDB Entry DOI: 10.7270/Q2VM4BZS
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258702
PNG
(4-chloro-N-((7R,8R)-8-(4-ethylphenylsulfonamido)-7...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)c3ccc(Cl)cc3)cc12 |r|
Show InChI InChI=1S/C25H25ClN2O4S/c1-2-16-3-12-21(13-4-16)33(31,32)28-24-22-15-20(11-7-17(22)8-14-23(24)29)27-25(30)18-5-9-19(26)10-6-18/h3-7,9-13,15,23-24,28-29H,2,8,14H2,1H3,(H,27,30)/t23-,24-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 340n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258757
PNG
((1S,2S)-N-((7R,8R)-8-(4-ethylphenylsulfonamido)-7-...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)[C@H]3C[C@@H]3c3ccccc3)cc12 |r|
Show InChI InChI=1S/C28H30N2O4S/c1-2-18-8-13-22(14-9-18)35(33,34)30-27-24-16-21(12-10-20(24)11-15-26(27)31)29-28(32)25-17-23(25)19-6-4-3-5-7-19/h3-10,12-14,16,23,25-27,30-31H,2,11,15,17H2,1H3,(H,29,32)/t23-,25+,26-,27-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 350n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50270679
PNG
(CHEMBL482676 | [5-(4-Chlorophenyl)furan-2-yl]-(4-c...)
Show SMILES Clc1ccc(cc1)-c1ccc(o1)C(=O)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H25ClN2O2/c22-17-8-6-16(7-9-17)19-10-11-20(26-19)21(25)24-14-12-23(13-15-24)18-4-2-1-3-5-18/h6-11,18H,1-5,12-15H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 350n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Nav1.2 channel expressed in HEK293 cells by whole cell voltage clamp technique


Bioorg Med Chem 16: 6379-86 (2008)


Article DOI: 10.1016/j.bmc.2008.05.003
BindingDB Entry DOI: 10.7270/Q2VH5NNT
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM50270679
PNG
(CHEMBL482676 | [5-(4-Chlorophenyl)furan-2-yl]-(4-c...)
Show SMILES Clc1ccc(cc1)-c1ccc(o1)C(=O)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H25ClN2O2/c22-17-8-6-16(7-9-17)19-10-11-20(26-19)21(25)24-14-12-23(13-15-24)18-4-2-1-3-5-18/h6-11,18H,1-5,12-15H2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 390n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current by whole cell patch clamp technique


Bioorg Med Chem 16: 6379-86 (2008)


Article DOI: 10.1016/j.bmc.2008.05.003
BindingDB Entry DOI: 10.7270/Q2VH5NNT
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM50270649
PNG
(1-[5-(4-Chlorophenyl)-2-furoyl]piperazine | CHEMBL...)
Show SMILES Clc1ccc(cc1)-c1ccc(o1)C(=O)N1CCNCC1
Show InChI InChI=1S/C15H15ClN2O2/c16-12-3-1-11(2-4-12)13-5-6-14(20-13)15(19)18-9-7-17-8-10-18/h1-6,17H,7-10H2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 430n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current by whole cell patch clamp technique


Bioorg Med Chem 16: 6379-86 (2008)


Article DOI: 10.1016/j.bmc.2008.05.003
BindingDB Entry DOI: 10.7270/Q2VH5NNT
More data for this
Ligand-Target Pair
Sodium channel protein type X alpha subunit


(Mus musculus)
BDBM50371254
PNG
(CHEMBL429830)
Show SMILES CCOc1ccc(cc1)-c1ccc(o1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C20H19NO3/c1-3-23-17-9-7-15(8-10-17)18-11-12-19(24-18)20(22)21-16-6-4-5-14(2)13-16/h4-13H,3H2,1-2H3,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 430n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assay


J Med Chem 51: 407-16 (2008)


Article DOI: 10.1021/jm070637u
BindingDB Entry DOI: 10.7270/Q2KK9CN7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258756
PNG
(CHEMBL467479 | N-((7R,8R)-8-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)C#Cc3ccccc3)cc12 |r|
Show InChI InChI=1S/C27H26N2O4S/c1-2-19-8-14-23(15-9-19)34(32,33)29-27-24-18-22(13-11-21(24)12-16-25(27)30)28-26(31)17-10-20-6-4-3-5-7-20/h3-9,11,13-15,18,25,27,29-30H,2,12,16H2,1H3,(H,28,31)/t25-,27-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 430n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258502
PNG
(CHEMBL512964 | N-((7R,8R)-7-hydroxy-8-(4-isopropyl...)
Show SMILES COc1cccc(c1)C(=O)Nc1ccc2CC[C@@H](O)[C@H](NS(=O)(=O)c3ccc(cc3)C(C)C)c2c1 |r|
Show InChI InChI=1S/C27H30N2O5S/c1-17(2)18-8-12-23(13-9-18)35(32,33)29-26-24-16-21(11-7-19(24)10-14-25(26)30)28-27(31)20-5-4-6-22(15-20)34-3/h4-9,11-13,15-17,25-26,29-30H,10,14H2,1-3H3,(H,28,31)/t25-,26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 430n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50207907
PNG
(CHEMBL239807 | N-((7R,8R)-8-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)c3cccc(OC)c3)cc12 |r|
Show InChI InChI=1S/C26H28N2O5S/c1-3-17-7-12-22(13-8-17)34(31,32)28-25-23-16-20(11-9-18(23)10-14-24(25)29)27-26(30)19-5-4-6-21(15-19)33-2/h4-9,11-13,15-16,24-25,28-29H,3,10,14H2,1-2H3,(H,27,30)/t24-,25-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 440n/an/an/an/an/an/a



Icagen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5 channel mediated delayed rectifier potassium current by patch-clamp technique


Bioorg Med Chem Lett 17: 2849-53 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.052
BindingDB Entry DOI: 10.7270/Q2VM4BZS
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50207907
PNG
(CHEMBL239807 | N-((7R,8R)-8-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)c3cccc(OC)c3)cc12 |r|
Show InChI InChI=1S/C26H28N2O5S/c1-3-17-7-12-22(13-8-17)34(31,32)28-25-23-16-20(11-9-18(23)10-14-24(25)29)27-26(30)19-5-4-6-21(15-19)33-2/h4-9,11-13,15-16,24-25,28-29H,3,10,14H2,1-2H3,(H,27,30)/t24-,25-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 440n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258670
PNG
(CHEMBL467040 | N-((7R,8R)-8-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)c3ccccc3OC)cc12 |r|
Show InChI InChI=1S/C26H28N2O5S/c1-3-17-8-13-20(14-9-17)34(31,32)28-25-22-16-19(12-10-18(22)11-15-23(25)29)27-26(30)21-6-4-5-7-24(21)33-2/h4-10,12-14,16,23,25,28-29H,3,11,15H2,1-2H3,(H,27,30)/t23-,25-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 450n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258671
PNG
(CHEMBL467041 | N-((7R,8R)-8-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)c3ccc(OC)cc3)cc12 |r|
Show InChI InChI=1S/C26H28N2O5S/c1-3-17-4-13-22(14-5-17)34(31,32)28-25-23-16-20(10-6-18(23)9-15-24(25)29)27-26(30)19-7-11-21(33-2)12-8-19/h4-8,10-14,16,24-25,28-29H,3,9,15H2,1-2H3,(H,27,30)/t24-,25-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 450n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Sodium channel protein type X alpha subunit


(Mus musculus)
BDBM50231767
PNG
(5-(4-cyanophenyl)-N-(3-methylphenyl)furan-2-carbox...)
Show SMILES Cc1cccc(NC(=O)c2ccc(o2)-c2ccc(cc2)C#N)c1
Show InChI InChI=1S/C19H14N2O2/c1-13-3-2-4-16(11-13)21-19(22)18-10-9-17(23-18)15-7-5-14(12-20)6-8-15/h2-11H,1H3,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 480n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assay


J Med Chem 51: 407-16 (2008)


Article DOI: 10.1021/jm070637u
BindingDB Entry DOI: 10.7270/Q2KK9CN7
More data for this
Ligand-Target Pair
Sodium channel protein type X alpha subunit


(Mus musculus)
BDBM50231779
PNG
(5-(4-chlorophenyl)-N-(3-methylphenyl)furan-2-carbo...)
Show SMILES Cc1cccc(NC(=O)c2ccc(o2)-c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C18H14ClNO2/c1-12-3-2-4-15(11-12)20-18(21)17-10-9-16(22-17)13-5-7-14(19)8-6-13/h2-11H,1H3,(H,20,21)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 480n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assay


J Med Chem 51: 407-16 (2008)


Article DOI: 10.1021/jm070637u
BindingDB Entry DOI: 10.7270/Q2KK9CN7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258800
PNG
((S)-N-(8-(4-ethylphenylsulfonamido)-5,6,7,8-tetrah...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1CCCc2ccc(NC(=O)c3cccc(OC)c3)cc12 |r|
Show InChI InChI=1S/C26H28N2O4S/c1-3-18-10-14-23(15-11-18)33(30,31)28-25-9-5-6-19-12-13-21(17-24(19)25)27-26(29)20-7-4-8-22(16-20)32-2/h4,7-8,10-17,25,28H,3,5-6,9H2,1-2H3,(H,27,29)/t25-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 590n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258799
PNG
(CHEMBL466858 | N-((1R,2R)-7-(3-benzylureido)-2-hyd...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)NCc3ccccc3)cc12 |r|
Show InChI InChI=1S/C26H29N3O4S/c1-2-18-8-13-22(14-9-18)34(32,33)29-25-23-16-21(12-10-20(23)11-15-24(25)30)28-26(31)27-17-19-6-4-3-5-7-19/h3-10,12-14,16,24-25,29-30H,2,11,15,17H2,1H3,(H2,27,28,31)/t24-,25-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 610n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258703
PNG
(CHEMBL467672 | N-((7R,8R)-8-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)c3cc(OC)cc(OC)c3)cc12 |r|
Show InChI InChI=1S/C27H30N2O6S/c1-4-17-5-10-23(11-6-17)36(32,33)29-26-24-15-20(9-7-18(24)8-12-25(26)30)28-27(31)19-13-21(34-2)16-22(14-19)35-3/h5-7,9-11,13-16,25-26,29-30H,4,8,12H2,1-3H3,(H,28,31)/t25-,26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 640n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258701
PNG
(3-chloro-N-((7R,8R)-8-(4-ethylphenylsulfonamido)-7...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)c3cccc(Cl)c3)cc12 |r|
Show InChI InChI=1S/C25H25ClN2O4S/c1-2-16-6-11-21(12-7-16)33(31,32)28-24-22-15-20(10-8-17(22)9-13-23(24)29)27-25(30)18-4-3-5-19(26)14-18/h3-8,10-12,14-15,23-24,28-29H,2,9,13H2,1H3,(H,27,30)/t23-,24-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 710n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Bioorg Med Chem Lett 19: 3063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.002
BindingDB Entry DOI: 10.7270/Q2ZS2WD4
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50207908
PNG
(CHEMBL391455 | N-((2S,3S)-3-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@@H]1[C@@H](O)Cc2ccc(NC(=O)c3cccc(OC)c3)cc12
Show InChI InChI=1S/C25H26N2O5S/c1-3-16-7-11-21(12-8-16)33(30,31)27-24-22-15-19(10-9-17(22)14-23(24)28)26-25(29)18-5-4-6-20(13-18)32-2/h4-13,15,23-24,27-28H,3,14H2,1-2H3,(H,26,29)/t23-,24-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 760n/an/an/an/an/an/a



Icagen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5 channel mediated delayed rectifier potassium current by patch-clamp technique


Bioorg Med Chem Lett 17: 2849-53 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.052
BindingDB Entry DOI: 10.7270/Q2VM4BZS
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50231775
PNG
((R)-5-(4-chlorophenyl)-N-(1-(4-(3-(4-(cyclopropane...)
Show SMILES C[C@@H](NC(=O)c1ccc(o1)-c1ccc(Cl)cc1)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1 |r|
Show InChI InChI=1S/C31H34ClN3O5/c1-21(33-30(37)28-14-13-27(40-28)22-5-9-25(32)10-6-22)31(38)35-18-16-34(17-19-35)15-2-20-39-26-11-7-24(8-12-26)29(36)23-3-4-23/h5-14,21,23H,2-4,15-20H2,1H3,(H,33,37)/t21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 800n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of hERG potassium channel expressed in CHO cells by isotope efflux assay


J Med Chem 51: 407-16 (2008)


Article DOI: 10.1021/jm070637u
BindingDB Entry DOI: 10.7270/Q2KK9CN7
More data for this
Ligand-Target Pair
Sodium channel protein type X alpha subunit


(Mus musculus)
BDBM50212239
PNG
(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)
Show SMILES COc1cc(NC(=O)c2ccc(o2)-c2ccc(Cl)cc2)cc(OC)c1
Show InChI InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 850n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assay


J Med Chem 51: 407-16 (2008)


Article DOI: 10.1021/jm070637u
BindingDB Entry DOI: 10.7270/Q2KK9CN7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50207910
PNG
(CHEMBL391488 | N-((2R,3R)-3-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)Cc2cccc(NC(=O)c3cccc(OC)c3)c12
Show InChI InChI=1S/C25H26N2O5S/c1-3-16-10-12-20(13-11-16)33(30,31)27-24-22(28)15-17-6-5-9-21(23(17)24)26-25(29)18-7-4-8-19(14-18)32-2/h4-14,22,24,27-28H,3,15H2,1-2H3,(H,26,29)/t22-,24+/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 880n/an/an/an/an/an/a



Icagen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5 channel mediated delayed rectifier potassium current by patch-clamp technique


Bioorg Med Chem Lett 17: 2849-53 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.052
BindingDB Entry DOI: 10.7270/Q2VM4BZS
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 109 total )  |  Next  |  Last  >>
Jump to: