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Compile Data Set for Download or QSAR

Found 173 hits with Last Name = 'han' and Initial = 'ek'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365698
PNG
(CHEMBL1958411)
Show SMILES CN(C1CCCCC1)c1nc(cc(=O)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C18H21N5O/c1-23(12-6-3-2-4-7-12)18-21-15(10-16(24)22-18)14-11-20-17-13(14)8-5-9-19-17/h5,8-12H,2-4,6-7H2,1H3,(H,19,20)(H,21,22,24)
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0.0900n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365703
PNG
(CHEMBL1958417)
Show SMILES CN1CCC(CC1)Nc1nc(cc(=O)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H20N6O/c1-23-7-4-11(5-8-23)20-17-21-14(9-15(24)22-17)13-10-19-16-12(13)3-2-6-18-16/h2-3,6,9-11H,4-5,7-8H2,1H3,(H,18,19)(H2,20,21,22,24)
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0.110n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365699
PNG
(CHEMBL1958412)
Show SMILES O=c1cc(nc(Nc2ccccc2)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H13N5O/c23-15-9-14(13-10-19-16-12(13)7-4-8-18-16)21-17(22-15)20-11-5-2-1-3-6-11/h1-10H,(H,18,19)(H2,20,21,22,23)
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0.120n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365702
PNG
(CHEMBL1958416)
Show SMILES O=c1cc(nc(NC2CCOCC2)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C16H17N5O2/c22-14-8-13(12-9-18-15-11(12)2-1-5-17-15)20-16(21-14)19-10-3-6-23-7-4-10/h1-2,5,8-10H,3-4,6-7H2,(H,17,18)(H2,19,20,21,22)
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0.140n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365701
PNG
(CHEMBL1958415)
Show SMILES O=c1cc(nc([nH]1)N1CCOCC1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C15H15N5O2/c21-13-8-12(11-9-17-14-10(11)2-1-3-16-14)18-15(19-13)20-4-6-22-7-5-20/h1-3,8-9H,4-7H2,(H,16,17)(H,18,19,21)
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0.180n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365700
PNG
(CHEMBL1958414)
Show SMILES COCCN(CCOC)c1nc(cc(=O)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H21N5O3/c1-24-8-6-22(7-9-25-2)17-20-14(10-15(23)21-17)13-11-19-16-12(13)4-3-5-18-16/h3-5,10-11H,6-9H2,1-2H3,(H,18,19)(H,20,21,23)
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0.180n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365705
PNG
(CHEMBL1958419)
Show SMILES OC1CCN(CC1)c1nc(cc(=O)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C16H17N5O2/c22-10-3-6-21(7-4-10)16-19-13(8-14(23)20-16)12-9-18-15-11(12)2-1-5-17-15/h1-2,5,8-10,22H,3-4,6-7H2,(H,17,18)(H,19,20,23)
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0.200n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365706
PNG
(CHEMBL1958420)
Show SMILES COC1CCN(CC1)c1nc(cc(=O)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H19N5O2/c1-24-11-4-7-22(8-5-11)17-20-14(9-15(23)21-17)13-10-19-16-12(13)3-2-6-18-16/h2-3,6,9-11H,4-5,7-8H2,1H3,(H,18,19)(H,20,21,23)
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0.200n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365704
PNG
(CHEMBL1958418)
Show SMILES O=c1cc(nc([nH]1)-c1ccccc1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H12N4O/c22-15-9-14(13-10-19-17-12(13)7-4-8-18-17)20-16(21-15)11-5-2-1-3-6-11/h1-10H,(H,18,19)(H,20,21,22)
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0.25n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365693
PNG
(CHEMBL1958406)
Show SMILES O=c1nc(nc(NC2CCCCC2)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C16H18N6O/c23-16-21-14(12-9-18-13-11(12)7-4-8-17-13)20-15(22-16)19-10-5-2-1-3-6-10/h4,7-10H,1-3,5-6H2,(H,17,18)(H2,19,20,21,22,23)
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0.300n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM35048
PNG
(benzothienopyrimidinone deriv., 20c)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(ccc4sc3c(=O)[nH]2)-c2ccc(O)cc2)C1 |r|
Show InChI InChI=1S/C21H19N3O3S/c25-14-4-1-12(2-5-14)13-3-6-17-16(9-13)19-20(28-17)21(27)23-18(22-19)11-24-8-7-15(26)10-24/h1-6,9,15,25-26H,7-8,10-11H2,(H,22,23,27)/t15-/m0/s1
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0.400 -53.6n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365692
PNG
(CHEMBL1958404)
Show SMILES O=c1cc(nc(NC2CCCCC2)[nH]1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C17H19N5O/c23-16-9-15(11-6-7-14-12(8-11)10-18-22-14)20-17(21-16)19-13-4-2-1-3-5-13/h6-10,13H,1-5H2,(H,18,22)(H2,19,20,21,23)
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0.5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365695
PNG
(CHEMBL1958408)
Show SMILES O=c1cc(cc(NC2CCCCC2)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C18H20N4O/c23-17-10-12(15-11-20-18-14(15)7-4-8-19-18)9-16(22-17)21-13-5-2-1-3-6-13/h4,7-11,13H,1-3,5-6H2,(H,19,20)(H2,21,22,23)
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0.5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35042
PNG
(benzothienopyrimidinone deriv., 18b)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1ccc(OCCCN)cc1
Show InChI InChI=1S/C22H24N4O2S/c1-26(2)13-19-24-20-17-12-15(6-9-18(17)29-21(20)22(27)25-19)14-4-7-16(8-5-14)28-11-3-10-23/h4-9,12H,3,10-11,13,23H2,1-2H3,(H,24,25,27)
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0.600 -52.6n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35048
PNG
(benzothienopyrimidinone deriv., 20c)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(ccc4sc3c(=O)[nH]2)-c2ccc(O)cc2)C1 |r|
Show InChI InChI=1S/C21H19N3O3S/c25-14-4-1-12(2-5-14)13-3-6-17-16(9-13)19-20(28-17)21(27)23-18(22-19)11-24-8-7-15(26)10-24/h1-6,9,15,25-26H,7-8,10-11H2,(H,22,23,27)/t15-/m0/s1
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0.700 -52.3n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35050
PNG
(benzothienopyrimidinone deriv., 20e)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(\C=C\C5CC5)ccc4sc3c(=O)[nH]2)C1 |r|
Show InChI InChI=1S/C20H21N3O2S/c24-14-7-8-23(10-14)11-17-21-18-15-9-13(4-3-12-1-2-12)5-6-16(15)26-19(18)20(25)22-17/h3-6,9,12,14,24H,1-2,7-8,10-11H2,(H,21,22,25)/b4-3+/t14-/m0/s1
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0.800 -51.9n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35043
PNG
(benzothienopyrimidinone deriv., 19a)
Show SMILES Oc1cccc(NCc2nc3c4cc(Br)ccc4sc3c(=O)[nH]2)c1
Show InChI InChI=1S/C17H12BrN3O2S/c18-9-4-5-13-12(6-9)15-16(24-13)17(23)21-14(20-15)8-19-10-2-1-3-11(22)7-10/h1-7,19,22H,8H2,(H,20,21,23)
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0.800 -51.9n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM35050
PNG
(benzothienopyrimidinone deriv., 20e)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(\C=C\C5CC5)ccc4sc3c(=O)[nH]2)C1 |r|
Show InChI InChI=1S/C20H21N3O2S/c24-14-7-8-23(10-14)11-17-21-18-15-9-13(4-3-12-1-2-12)5-6-16(15)26-19(18)20(25)22-17/h3-6,9,12,14,24H,1-2,7-8,10-11H2,(H,21,22,25)/b4-3+/t14-/m0/s1
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0.900 -51.6n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM34997
PNG
(benzothienopyrimidinone deriv., 6n)
Show SMILES Oc1cccc(NCc2nc3c4cc(Cl)ccc4sc3c(=O)[nH]2)c1
Show InChI InChI=1S/C17H12ClN3O2S/c18-9-4-5-13-12(6-9)15-16(24-13)17(23)21-14(20-15)8-19-10-2-1-3-11(22)7-10/h1-7,19,22H,8H2,(H,20,21,23)
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0.900 -51.3n/an/an/an/an/a7.523



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35021
PNG
(benzothienopyrimidinone deriv., 14f)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1cccc(O)c1
Show InChI InChI=1S/C19H17N3O2S/c1-22(2)10-16-20-17-14-9-12(11-4-3-5-13(23)8-11)6-7-15(14)25-18(17)19(24)21-16/h3-9,23H,10H2,1-2H3,(H,20,21,24)
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1 -51.4n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35028
PNG
(benzothienopyrimidinone deriv., 14m)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1ccc(O)c(F)c1
Show InChI InChI=1S/C19H16FN3O2S/c1-23(2)9-16-21-17-12-7-10(11-3-5-14(24)13(20)8-11)4-6-15(12)26-18(17)19(25)22-16/h3-8,24H,9H2,1-2H3,(H,21,22,25)
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1 -51.4n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35041
PNG
(benzothienopyrimidinone deriv., 18a)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1ccc(OCC(O)CO)cc1
Show InChI InChI=1S/C22H23N3O4S/c1-25(2)10-19-23-20-17-9-14(5-8-18(17)30-21(20)22(28)24-19)13-3-6-16(7-4-13)29-12-15(27)11-26/h3-9,15,26-27H,10-12H2,1-2H3,(H,23,24,28)
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1 -51.4n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35012
PNG
(benzothienopyrimidinone deriv., 12b)
Show SMILES CN(C)Cc1nc2c3cc(\C=C\C4CC4)ccc3sc2c(=O)[nH]1
Show InChI InChI=1S/C18H19N3OS/c1-21(2)10-15-19-16-13-9-12(6-5-11-3-4-11)7-8-14(13)23-17(16)18(22)20-15/h5-9,11H,3-4,10H2,1-2H3,(H,19,20,22)/b6-5+
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1 -51.0n/an/an/an/an/a7.523



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365696
PNG
(CHEMBL1958409)
Show SMILES O=c1cc(NC2CCCCC2)cc([nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C18H20N4O/c23-17-10-13(21-12-5-2-1-3-6-12)9-16(22-17)15-11-20-18-14(15)7-4-8-19-18/h4,7-12H,1-3,5-6H2,(H,19,20)(H2,21,22,23)
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1.10n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365694
PNG
(CHEMBL1958407)
Show SMILES O=c1nc(cc(NC2CCCCC2)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H19N5O/c23-17-21-14(13-10-19-16-12(13)7-4-8-18-16)9-15(22-17)20-11-5-2-1-3-6-11/h4,7-11H,1-3,5-6H2,(H,18,19)(H2,20,21,22,23)
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1.40n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365689
PNG
(CHEMBL1958401)
Show SMILES O=c1cc(nc(NC2CCCCC2)[nH]1)-c1ccncc1
Show InChI InChI=1S/C15H18N4O/c20-14-10-13(11-6-8-16-9-7-11)18-15(19-14)17-12-4-2-1-3-5-12/h6-10,12H,1-5H2,(H2,17,18,19,20)
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2n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM35033
PNG
(benzothienopyrimidinone deriv., 15a)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1ccsc1
Show InChI InChI=1S/C17H15N3OS2/c1-20(2)8-14-18-15-12-7-10(11-5-6-22-9-11)3-4-13(12)23-16(15)17(21)19-14/h3-7,9H,8H2,1-2H3,(H,18,19,21)
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2 -49.7n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM35026
PNG
(benzothienopyrimidinone deriv., 14k)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1ccc(N)cc1
Show InChI InChI=1S/C19H18N4OS/c1-23(2)10-16-21-17-14-9-12(11-3-6-13(20)7-4-11)5-8-15(14)25-18(17)19(24)22-16/h3-9H,10,20H2,1-2H3,(H,21,22,24)
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2 -49.7n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35037
PNG
(benzothienopyrimidinone deriv., 16a)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1cccnc1
Show InChI InChI=1S/C18H16N4OS/c1-22(2)10-15-20-16-13-8-11(12-4-3-7-19-9-12)5-6-14(13)24-17(16)18(23)21-15/h3-9H,10H2,1-2H3,(H,20,21,23)
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2 -49.7n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM35012
PNG
(benzothienopyrimidinone deriv., 12b)
Show SMILES CN(C)Cc1nc2c3cc(\C=C\C4CC4)ccc3sc2c(=O)[nH]1
Show InChI InChI=1S/C18H19N3OS/c1-21(2)10-15-19-16-13-9-12(6-5-11-3-4-11)7-8-14(13)23-17(16)18(22)20-15/h5-9,11H,3-4,10H2,1-2H3,(H,19,20,22)/b6-5+
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2 -49.7n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM35048
PNG
(benzothienopyrimidinone deriv., 20c)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(ccc4sc3c(=O)[nH]2)-c2ccc(O)cc2)C1 |r|
Show InChI InChI=1S/C21H19N3O3S/c25-14-4-1-12(2-5-14)13-3-6-17-16(9-13)19-20(28-17)21(27)23-18(22-19)11-24-8-7-15(26)10-24/h1-6,9,15,25-26H,7-8,10-11H2,(H,22,23,27)/t15-/m0/s1
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2 -49.7n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35025
PNG
(benzothienopyrimidinone deriv., 14j)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1ccc(O)cc1
Show InChI InChI=1S/C19H17N3O2S/c1-22(2)10-16-20-17-14-9-12(11-3-6-13(23)7-4-11)5-8-15(14)25-18(17)19(24)21-16/h3-9,23H,10H2,1-2H3,(H,20,21,24)
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2 -49.7n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35045
PNG
(benzothienopyrimidinone deriv., 19c)
Show SMILES Oc1cccc(NCc2nc3c4cc(ccc4sc3c(=O)[nH]2)-c2ccccc2)c1
Show InChI InChI=1S/C23H17N3O2S/c27-17-8-4-7-16(12-17)24-13-20-25-21-18-11-15(14-5-2-1-3-6-14)9-10-19(18)29-22(21)23(28)26-20/h1-12,24,27H,13H2,(H,25,26,28)
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2 -49.7n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35044
PNG
(benzothienopyrimidinone deriv., 19b)
Show SMILES Oc1cccc(NCc2nc3c4cc(ccc4sc3c(=O)[nH]2)-c2ccsc2)c1
Show InChI InChI=1S/C21H15N3O2S2/c25-15-3-1-2-14(9-15)22-10-18-23-19-16-8-12(13-6-7-27-11-13)4-5-17(16)28-20(19)21(26)24-18/h1-9,11,22,25H,10H2,(H,23,24,26)
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2 -49.7n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35026
PNG
(benzothienopyrimidinone deriv., 14k)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1ccc(N)cc1
Show InChI InChI=1S/C19H18N4OS/c1-23(2)10-16-21-17-14-9-12(11-3-6-13(20)7-4-11)5-8-15(14)25-18(17)19(24)22-16/h3-9H,10,20H2,1-2H3,(H,21,22,24)
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2 -49.7n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM35041
PNG
(benzothienopyrimidinone deriv., 18a)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1ccc(OCC(O)CO)cc1
Show InChI InChI=1S/C22H23N3O4S/c1-25(2)10-19-23-20-17-9-14(5-8-18(17)30-21(20)22(28)24-19)13-3-6-16(7-4-13)29-12-15(27)11-26/h3-9,15,26-27H,10-12H2,1-2H3,(H,23,24,28)
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2 -49.7n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35015
PNG
(benzothienopyrimidinone deriv., 13c)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)C#CCCCCN1CCCCC1
Show InChI InChI=1S/C24H30N4OS/c1-27(2)17-21-25-22-19-16-18(11-12-20(19)30-23(22)24(29)26-21)10-6-3-4-7-13-28-14-8-5-9-15-28/h11-12,16H,3-5,7-9,13-15,17H2,1-2H3,(H,25,26,29)
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3 -48.6n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35019
PNG
(benzothienopyrimidinone deriv., 14d)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1cccc(Cl)c1
Show InChI InChI=1S/C19H16ClN3OS/c1-23(2)10-16-21-17-14-9-12(11-4-3-5-13(20)8-11)6-7-15(14)25-18(17)19(24)22-16/h3-9H,10H2,1-2H3,(H,21,22,24)
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3 -48.6n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM35046
PNG
(benzothienopyrimidinone deriv., 20a)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(ccc4sc3c(=O)[nH]2)-c2ccsc2)C1 |r|
Show InChI InChI=1S/C19H17N3O2S2/c23-13-3-5-22(8-13)9-16-20-17-14-7-11(12-4-6-25-10-12)1-2-15(14)26-18(17)19(24)21-16/h1-2,4,6-7,10,13,23H,3,5,8-9H2,(H,20,21,24)/t13-/m0/s1
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3 -48.6n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM35025
PNG
(benzothienopyrimidinone deriv., 14j)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1ccc(O)cc1
Show InChI InChI=1S/C19H17N3O2S/c1-22(2)10-16-20-17-14-9-12(11-3-6-13(23)7-4-11)5-8-15(14)25-18(17)19(24)21-16/h3-9,23H,10H2,1-2H3,(H,20,21,24)
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3 -48.6n/an/an/an/an/an/a25



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Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35047
PNG
(benzothienopyrimidinone deriv., 20b)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(ccc4sc3c(=O)[nH]2)-c2ccccc2)C1 |r|
Show InChI InChI=1S/C21H19N3O2S/c25-15-8-9-24(11-15)12-18-22-19-16-10-14(13-4-2-1-3-5-13)6-7-17(16)27-20(19)21(26)23-18/h1-7,10,15,25H,8-9,11-12H2,(H,22,23,26)/t15-/m0/s1
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Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM35034
PNG
(benzothienopyrimidinone deriv., 15b)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1ccc[nH]1
Show InChI InChI=1S/C17H16N4OS/c1-21(2)9-14-19-15-11-8-10(12-4-3-7-18-12)5-6-13(11)23-16(15)17(22)20-14/h3-8,18H,9H2,1-2H3,(H,19,20,22)
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3 -48.6n/an/an/an/an/an/a25



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Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM35037
PNG
(benzothienopyrimidinone deriv., 16a)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1cccnc1
Show InChI InChI=1S/C18H16N4OS/c1-22(2)10-15-20-16-13-8-11(12-4-3-7-19-9-12)5-6-14(13)24-17(16)18(23)21-15/h3-9H,10H2,1-2H3,(H,20,21,23)
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3 -48.6n/an/an/an/an/an/a25



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Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35031
PNG
(benzothienopyrimidinone deriv., 14p)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C19H15ClFN3OS/c1-24(2)9-16-22-17-14-7-10(11-5-12(20)8-13(21)6-11)3-4-15(14)26-18(17)19(25)23-16/h3-8H,9H2,1-2H3,(H,22,23,25)
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3 -48.6n/an/an/an/an/an/a25



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Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35049
PNG
(benzothienopyrimidinone deriv., 20d)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(ccc4sc3c(=O)[nH]2)-c2ccc(cc2)C#N)C1 |r|
Show InChI InChI=1S/C22H18N4O2S/c23-10-13-1-3-14(4-2-13)15-5-6-18-17(9-15)20-21(29-18)22(28)25-19(24-20)12-26-8-7-16(27)11-26/h1-6,9,16,27H,7-8,11-12H2,(H,24,25,28)/t16-/m0/s1
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4 -47.9n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM35021
PNG
(benzothienopyrimidinone deriv., 14f)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1cccc(O)c1
Show InChI InChI=1S/C19H17N3O2S/c1-22(2)10-16-20-17-14-9-12(11-4-3-5-13(23)8-11)6-7-15(14)25-18(17)19(24)21-16/h3-9,23H,10H2,1-2H3,(H,20,21,24)
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Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35039
PNG
(benzothienopyrimidinone deriv., 17a)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)N1CCCC1
Show InChI InChI=1S/C17H20N4OS/c1-20(2)10-14-18-15-12-9-11(21-7-3-4-8-21)5-6-13(12)23-16(15)17(22)19-14/h5-6,9H,3-4,7-8,10H2,1-2H3,(H,18,19,22)
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4 -47.9n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35033
PNG
(benzothienopyrimidinone deriv., 15a)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1ccsc1
Show InChI InChI=1S/C17H15N3OS2/c1-20(2)8-14-18-15-12-7-10(11-5-6-22-9-11)3-4-13(12)23-16(15)17(21)19-14/h3-7,9H,8H2,1-2H3,(H,18,19,21)
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4 -47.9n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35032
PNG
(benzothienopyrimidinone deriv., 14q)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C19H15Cl2N3OS/c1-24(2)9-16-22-17-14-7-10(11-5-12(20)8-13(21)6-11)3-4-15(14)26-18(17)19(25)23-16/h3-8H,9H2,1-2H3,(H,22,23,25)
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4 -47.9n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35029
PNG
(benzothienopyrimidinone deriv., 14n)
Show SMILES CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C21H22N4OS/c1-24(2)12-18-22-19-16-11-14(13-5-8-15(9-6-13)25(3)4)7-10-17(16)27-20(19)21(26)23-18/h5-11H,12H2,1-4H3,(H,22,23,26)
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4 -47.9n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
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