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Compile Data Set for Download or QSAR

Found 320 hits with Last Name = 'harriman' and Initial = 'sp'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50236362
PNG
(CHEMBL429743 | N-(4-chlorophenyl)-6-(6,7-dimethoxy...)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H21ClN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-13-12-25(23)35-20-10-11-21-17(14-20)4-3-5-22(21)28(32)31-19-8-6-18(29)7-9-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 0.0300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1695-705 (2008)


Article DOI: 10.1021/jm701129j
BindingDB Entry DOI: 10.7270/Q28K79ZW
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375681
PNG
(CHEMBL411630)
Show SMILES COc1cc2nccc(Oc3ccc4N(CCOc4c3)C(=O)Nc3ccc(C)cc3)c2cc1OC
Show InChI InChI=1S/C27H25N3O5/c1-17-4-6-18(7-5-17)29-27(31)30-12-13-34-24-14-19(8-9-22(24)30)35-23-10-11-28-21-16-26(33-3)25(32-2)15-20(21)23/h4-11,14-16H,12-13H2,1-3H3,(H,29,31)
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n/an/a 0.200n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1695-705 (2008)


Article DOI: 10.1021/jm701129j
BindingDB Entry DOI: 10.7270/Q28K79ZW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376042
PNG
(CHEMBL409512)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1C(N)=O
Show InChI InChI=1S/C28H20ClN3O4/c1-35-26-15-24-22(14-23(26)27(30)33)25(11-12-31-24)36-19-9-10-20-16(13-19)3-2-4-21(20)28(34)32-18-7-5-17(29)6-8-18/h2-15H,1H3,(H2,30,33)(H,32,34)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376040
PNG
(CHEMBL272824)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c2cc1OC
Show InChI InChI=1S/C28H22N2O4/c1-32-26-16-23-24(17-27(26)33-2)29-14-13-25(23)34-20-11-12-21-18(15-20)7-6-10-22(21)28(31)30-19-8-4-3-5-9-19/h3-17H,1-2H3,(H,30,31)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376025
PNG
(AMG-0309 | CHEMBL409538)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccon3)c2cc1OC
Show InChI InChI=1S/C25H19N3O5/c1-30-22-13-19-20(14-23(22)31-2)26-10-8-21(19)33-16-6-7-17-15(12-16)4-3-5-18(17)25(29)27-24-9-11-32-28-24/h3-14H,1-2H3,(H,27,28,29)
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n/an/a 0.200n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376036
PNG
(CHEMBL270092)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cccc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C28H21ClN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-12-11-25(23)35-20-9-10-21-17(13-20)5-3-8-22(21)28(32)31-19-7-4-6-18(29)14-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 0.300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376030
PNG
(CHEMBL269916)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cc(Cl)cc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C28H20Cl2N2O4/c1-34-26-14-23-24(15-27(26)35-2)31-9-8-25(23)36-20-6-7-21-16(10-20)4-3-5-22(21)28(33)32-19-12-17(29)11-18(30)13-19/h3-15H,1-2H3,(H,32,33)
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n/an/a 0.300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376026
PNG
(CHEMBL272691)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3nccs3)c2cc1OC
Show InChI InChI=1S/C25H19N3O4S/c1-30-22-13-19-20(14-23(22)31-2)26-9-8-21(19)32-16-6-7-17-15(12-16)4-3-5-18(17)24(29)28-25-27-10-11-33-25/h3-14H,1-2H3,(H,27,28,29)
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n/an/a 0.300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376019
PNG
(CHEMBL429585)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3F)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H20ClFN2O4/c1-34-25-14-21-22(15-26(25)35-2)31-13-12-23(21)36-24-11-10-18-19(27(24)30)4-3-5-20(18)28(33)32-17-8-6-16(29)7-9-17/h3-15H,1-2H3,(H,32,33)
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n/an/a 0.300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375996
PNG
(CHEMBL272250)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)c2cc1C(N)=O
Show InChI InChI=1S/C25H21N3O4/c1-31-23-13-21-19(12-20(23)24(26)29)22(9-10-27-21)32-16-7-8-17-14(11-16)3-2-4-18(17)25(30)28-15-5-6-15/h2-4,7-13,15H,5-6H2,1H3,(H2,26,29)(H,28,30)
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n/an/a 0.370n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


J Med Chem 51: 1668-80 (2008)


Article DOI: 10.1021/jm701098w
BindingDB Entry DOI: 10.7270/Q2F47Q0C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375999
PNG
(CHEMBL270342)
Show SMILES COc1ccc2c(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)ccnc2c1
Show InChI InChI=1S/C24H20N2O3/c1-28-17-7-10-21-22(14-17)25-12-11-23(21)29-18-8-9-19-15(13-18)3-2-4-20(19)24(27)26-16-5-6-16/h2-4,7-14,16H,5-6H2,1H3,(H,26,27)
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n/an/a 0.450n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


J Med Chem 51: 1668-80 (2008)


Article DOI: 10.1021/jm701098w
BindingDB Entry DOI: 10.7270/Q2F47Q0C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50236362
PNG
(CHEMBL429743 | N-(4-chlorophenyl)-6-(6,7-dimethoxy...)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H21ClN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-13-12-25(23)35-20-10-11-21-17(14-20)4-3-5-22(21)28(32)31-19-8-6-18(29)7-9-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 0.480n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


J Med Chem 51: 1668-80 (2008)


Article DOI: 10.1021/jm701098w
BindingDB Entry DOI: 10.7270/Q2F47Q0C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50236362
PNG
(CHEMBL429743 | N-(4-chlorophenyl)-6-(6,7-dimethoxy...)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H21ClN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-13-12-25(23)35-20-10-11-21-17(14-20)4-3-5-22(21)28(32)31-19-8-6-18(29)7-9-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 0.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375679
PNG
(CHEMBL270548)
Show SMILES COc1cc2nccc(Oc3ccc4N(CCOc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C26H22ClN3O5/c1-32-24-14-19-20(15-25(24)33-2)28-10-9-22(19)35-18-7-8-21-23(13-18)34-12-11-30(21)26(31)29-17-5-3-16(27)4-6-17/h3-10,13-15H,11-12H2,1-2H3,(H,29,31)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1695-705 (2008)


Article DOI: 10.1021/jm701129j
BindingDB Entry DOI: 10.7270/Q28K79ZW
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375690
PNG
(CHEMBL270954)
Show SMILES COc1cc2nccc(Oc3ccc4N(CCOc4c3)C(=O)Nc3ccc(C)cc3)c2cc1C(N)=O
Show InChI InChI=1S/C27H24N4O5/c1-16-3-5-17(6-4-16)30-27(33)31-11-12-35-25-13-18(7-8-22(25)31)36-23-9-10-29-21-15-24(34-2)20(26(28)32)14-19(21)23/h3-10,13-15H,11-12H2,1-2H3,(H2,28,32)(H,30,33)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1695-705 (2008)


Article DOI: 10.1021/jm701129j
BindingDB Entry DOI: 10.7270/Q28K79ZW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376035
PNG
(AMG-6168 | CHEMBL411091)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(C)cc3)c2cc1OC
Show InChI InChI=1S/C29H24N2O4/c1-18-7-9-20(10-8-18)31-29(32)23-6-4-5-19-15-21(11-12-22(19)23)35-26-13-14-30-25-17-28(34-3)27(33-2)16-24(25)26/h4-17H,1-3H3,(H,31,32)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376034
PNG
(CHEMBL271563)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cccc(c3)C(F)(F)F)c2cc1OC
Show InChI InChI=1S/C29H21F3N2O4/c1-36-26-15-23-24(16-27(26)37-2)33-12-11-25(23)38-20-9-10-21-17(13-20)5-3-8-22(21)28(35)34-19-7-4-6-18(14-19)29(30,31)32/h3-16H,1-2H3,(H,34,35)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376033
PNG
(CHEMBL270985)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(cc3)C(F)(F)F)c2cc1OC
Show InChI InChI=1S/C29H21F3N2O4/c1-36-26-15-23-24(16-27(26)37-2)33-13-12-25(23)38-20-10-11-21-17(14-20)4-3-5-22(21)28(35)34-19-8-6-18(7-9-19)29(30,31)32/h3-16H,1-2H3,(H,34,35)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50236362
PNG
(CHEMBL429743 | N-(4-chlorophenyl)-6-(6,7-dimethoxy...)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H21ClN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-13-12-25(23)35-20-10-11-21-17(14-20)4-3-5-22(21)28(32)31-19-8-6-18(29)7-9-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 0.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376038
PNG
(CHEMBL412291)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cccc(F)c3)c2cc1OC
Show InChI InChI=1S/C28H21FN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-12-11-25(23)35-20-9-10-21-17(13-20)5-3-8-22(21)28(32)31-19-7-4-6-18(29)14-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375683
PNG
(CHEMBL409867)
Show SMILES COc1cc2nccc(Oc3ccc4N(CCOc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1C(N)=O
Show InChI InChI=1S/C26H21ClN4O5/c1-34-23-14-20-18(13-19(23)25(28)32)22(8-9-29-20)36-17-6-7-21-24(12-17)35-11-10-31(21)26(33)30-16-4-2-15(27)3-5-16/h2-9,12-14H,10-11H2,1H3,(H2,28,32)(H,30,33)
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n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1695-705 (2008)


Article DOI: 10.1021/jm701129j
BindingDB Entry DOI: 10.7270/Q28K79ZW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376024
PNG
(CHEMBL259461)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cc(C)on3)c2cc1OC
Show InChI InChI=1S/C26H21N3O5/c1-15-11-25(29-34-15)28-26(30)19-6-4-5-16-12-17(7-8-18(16)19)33-22-9-10-27-21-14-24(32-3)23(31-2)13-20(21)22/h4-14H,1-3H3,(H,28,29,30)
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n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50236856
PNG
(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)c2cc1OC
Show InChI InChI=1S/C25H22N2O4/c1-29-23-13-20-21(14-24(23)30-2)26-11-10-22(20)31-17-8-9-18-15(12-17)4-3-5-19(18)25(28)27-16-6-7-16/h3-5,8-14,16H,6-7H2,1-2H3,(H,27,28)
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n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50236856
PNG
(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)c2cc1OC
Show InChI InChI=1S/C25H22N2O4/c1-29-23-13-20-21(14-24(23)30-2)26-11-10-22(20)31-17-8-9-18-15(12-17)4-3-5-19(18)25(28)27-16-6-7-16/h3-5,8-14,16H,6-7H2,1-2H3,(H,27,28)
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n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


J Med Chem 51: 1668-80 (2008)


Article DOI: 10.1021/jm701098w
BindingDB Entry DOI: 10.7270/Q2F47Q0C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376032
PNG
(CHEMBL407715)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(cc3)C(C)(C)C)c2cc1OC
Show InChI InChI=1S/C32H30N2O4/c1-32(2,3)21-9-11-22(12-10-21)34-31(35)25-8-6-7-20-17-23(13-14-24(20)25)38-28-15-16-33-27-19-30(37-5)29(36-4)18-26(27)28/h6-19H,1-5H3,(H,34,35)
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n/an/a 0.700n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376020
PNG
(CHEMBL269915)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccccn3)c2cc1OC
Show InChI InChI=1S/C27H21N3O4/c1-32-24-15-21-22(16-25(24)33-2)28-13-11-23(21)34-18-9-10-19-17(14-18)6-5-7-20(19)27(31)30-26-8-3-4-12-29-26/h3-16H,1-2H3,(H,29,30,31)
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n/an/a 0.800n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376028
PNG
(CHEMBL406388)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cccnc3)c2cc1OC
Show InChI InChI=1S/C27H21N3O4/c1-32-25-14-22-23(15-26(25)33-2)29-12-10-24(22)34-19-8-9-20-17(13-19)5-3-7-21(20)27(31)30-18-6-4-11-28-16-18/h3-16H,1-2H3,(H,30,31)
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n/an/a 0.800n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376023
PNG
(CHEMBL408478)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cc(on3)C(C)(C)C)c2cc1OC
Show InChI InChI=1S/C29H27N3O5/c1-29(2,3)26-16-27(32-37-26)31-28(33)20-8-6-7-17-13-18(9-10-19(17)20)36-23-11-12-30-22-15-25(35-5)24(34-4)14-21(22)23/h6-16H,1-5H3,(H,31,32,33)
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n/an/a 0.800n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376003
PNG
(CHEMBL271984)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C22H18N2O4/c1-26-20-11-17-18(12-21(20)27-2)24-9-8-19(17)28-14-6-7-15-13(10-14)4-3-5-16(15)22(23)25/h3-12H,1-2H3,(H2,23,25)
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n/an/a 0.900n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


J Med Chem 51: 1668-80 (2008)


Article DOI: 10.1021/jm701098w
BindingDB Entry DOI: 10.7270/Q2F47Q0C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375676
PNG
(CHEMBL272875)
Show SMILES CCNC(=O)N1CCOc2cc(Oc3ccnc4cc(OC)c(OC)cc34)ccc12
Show InChI InChI=1S/C22H23N3O5/c1-4-23-22(26)25-9-10-29-19-11-14(5-6-17(19)25)30-18-7-8-24-16-13-21(28-3)20(27-2)12-15(16)18/h5-8,11-13H,4,9-10H2,1-3H3,(H,23,26)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1695-705 (2008)


Article DOI: 10.1021/jm701129j
BindingDB Entry DOI: 10.7270/Q28K79ZW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376037
PNG
(CHEMBL410841)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(F)cc3)c2cc1OC
Show InChI InChI=1S/C28H21FN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-13-12-25(23)35-20-10-11-21-17(14-20)4-3-5-22(21)28(32)31-19-8-6-18(29)7-9-19/h3-16H,1-2H3,(H,31,32)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375692
PNG
(CHEMBL272878)
Show SMILES COc1cc2nccc(Oc3ccc4N(CCOc4c3)C(=O)Nc3cccc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C26H22ClN3O5/c1-32-24-14-19-20(15-25(24)33-2)28-9-8-22(19)35-18-6-7-21-23(13-18)34-11-10-30(21)26(31)29-17-5-3-4-16(27)12-17/h3-9,12-15H,10-11H2,1-2H3,(H,29,31)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1695-705 (2008)


Article DOI: 10.1021/jm701129j
BindingDB Entry DOI: 10.7270/Q28K79ZW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376029
PNG
(CHEMBL269914)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2cc1OC
Show InChI InChI=1S/C29H20ClF3N2O4/c1-37-26-14-21-24(15-27(26)38-2)34-11-10-25(21)39-18-7-8-19-16(12-18)4-3-5-20(19)28(36)35-17-6-9-23(30)22(13-17)29(31,32)33/h3-15H,1-2H3,(H,35,36)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375688
PNG
(CHEMBL270058)
Show SMILES COc1cc2nccc(Oc3ccc4N(CCOc4c3)C(=O)Nc3ccccc3C)c2cc1OC
Show InChI InChI=1S/C27H25N3O5/c1-17-6-4-5-7-20(17)29-27(31)30-12-13-34-24-14-18(8-9-22(24)30)35-23-10-11-28-21-16-26(33-3)25(32-2)15-19(21)23/h4-11,14-16H,12-13H2,1-3H3,(H,29,31)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1695-705 (2008)


Article DOI: 10.1021/jm701129j
BindingDB Entry DOI: 10.7270/Q28K79ZW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376014
PNG
(CHEMBL270978)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cc(C)no3)c2cc1OC
Show InChI InChI=1S/C26H21N3O5/c1-15-11-25(34-29-15)28-26(30)19-6-4-5-16-12-17(7-8-18(16)19)33-22-9-10-27-21-14-24(32-3)23(31-2)13-20(21)22/h4-14H,1-3H3,(H,28,30)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376044
PNG
(CHEMBL273062)
Show SMILES COc1ccc2c(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)ccnc2c1
Show InChI InChI=1S/C27H19ClN2O3/c1-32-20-9-12-24-25(16-20)29-14-13-26(24)33-21-10-11-22-17(15-21)3-2-4-23(22)27(31)30-19-7-5-18(28)6-8-19/h2-16H,1H3,(H,30,31)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375682
PNG
(CHEMBL270057)
Show SMILES COc1cc2nccc(Oc3ccc4N(CCOc4c3)C(=O)Nc3cccc(C)c3)c2cc1OC
Show InChI InChI=1S/C27H25N3O5/c1-17-5-4-6-18(13-17)29-27(31)30-11-12-34-24-14-19(7-8-22(24)30)35-23-9-10-28-21-16-26(33-3)25(32-2)15-20(21)23/h4-10,13-16H,11-12H2,1-3H3,(H,29,31)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1695-705 (2008)


Article DOI: 10.1021/jm701129j
BindingDB Entry DOI: 10.7270/Q28K79ZW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50245420
PNG
(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Show SMILES COc1cc2nccc(Oc3ccc4c(NC(=O)c5cccc(c5)C(F)(F)F)nn(C)c4c3)c2cc1OC
Show InChI InChI=1S/C27H21F3N4O4/c1-34-21-12-17(38-22-9-10-31-20-14-24(37-3)23(36-2)13-19(20)22)7-8-18(21)25(33-34)32-26(35)15-5-4-6-16(11-15)27(28,29)30/h4-14H,1-3H3,(H,32,33,35)
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n/an/a 1n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant KDR by HTRF assay


Bioorg Med Chem Lett 18: 4844-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.080
BindingDB Entry DOI: 10.7270/Q2W9591V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50245422
PNG
(6-(6,7-dimethoxyquinolin-4-yloxy)-N-(2-methoxyphen...)
Show SMILES COc1ccccc1Nc1cccc2cc(Oc3ccnc4cc(OC)c(OC)cc34)ccc12
Show InChI InChI=1S/C28H24N2O4/c1-31-26-10-5-4-8-23(26)30-22-9-6-7-18-15-19(11-12-20(18)22)34-25-13-14-29-24-17-28(33-3)27(32-2)16-21(24)25/h4-17,30H,1-3H3
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n/an/a 1n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant KDR by HTRF assay


Bioorg Med Chem Lett 18: 4844-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.080
BindingDB Entry DOI: 10.7270/Q2W9591V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50245169
PNG
(1-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-i...)
Show SMILES COc1ccc(NC(=O)Nc2nn(C)c3cc(Oc4ccnc5cc(OC)c(OC)cc45)ccc23)cc1
Show InChI InChI=1S/C27H25N5O5/c1-32-22-13-18(37-23-11-12-28-21-15-25(36-4)24(35-3)14-20(21)23)9-10-19(22)26(31-32)30-27(33)29-16-5-7-17(34-2)8-6-16/h5-15H,1-4H3,(H2,29,30,31,33)
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n/an/a 1n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant KDR by HTRF assay


Bioorg Med Chem Lett 18: 4844-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.080
BindingDB Entry DOI: 10.7270/Q2W9591V
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50236362
PNG
(CHEMBL429743 | N-(4-chlorophenyl)-6-(6,7-dimethoxy...)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H21ClN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-13-12-25(23)35-20-10-11-21-17(14-20)4-3-5-22(21)28(32)31-19-8-6-18(29)7-9-19/h3-16H,1-2H3,(H,31,32)
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n/an/a<1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50375682
PNG
(CHEMBL270057)
Show SMILES COc1cc2nccc(Oc3ccc4N(CCOc4c3)C(=O)Nc3cccc(C)c3)c2cc1OC
Show InChI InChI=1S/C27H25N3O5/c1-17-5-4-6-18(13-17)29-27(31)30-11-12-34-24-14-19(7-8-22(24)30)35-23-9-10-28-21-16-26(33-3)25(32-2)15-20(21)23/h4-10,13-16H,11-12H2,1-3H3,(H,29,31)
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lck


J Med Chem 51: 1695-705 (2008)


Article DOI: 10.1021/jm701129j
BindingDB Entry DOI: 10.7270/Q28K79ZW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375682
PNG
(CHEMBL270057)
Show SMILES COc1cc2nccc(Oc3ccc4N(CCOc4c3)C(=O)Nc3cccc(C)c3)c2cc1OC
Show InChI InChI=1S/C27H25N3O5/c1-17-5-4-6-18(13-17)29-27(31)30-11-12-34-24-14-19(7-8-22(24)30)35-23-9-10-28-21-16-26(33-3)25(32-2)15-20(21)23/h4-10,13-16H,11-12H2,1-3H3,(H,29,31)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


J Med Chem 51: 1695-705 (2008)


Article DOI: 10.1021/jm701129j
BindingDB Entry DOI: 10.7270/Q28K79ZW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375673
PNG
(CHEMBL270306)
Show SMILES COc1cc2nccc(Oc3ccc4N(CCOc4c3)C(=O)N[C@@H](C)c3ccccc3)c2cc1OC
Show InChI InChI=1S/C28H27N3O5/c1-18(19-7-5-4-6-8-19)30-28(32)31-13-14-35-25-15-20(9-10-23(25)31)36-24-11-12-29-22-17-27(34-3)26(33-2)16-21(22)24/h4-12,15-18H,13-14H2,1-3H3,(H,30,32)/t18-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1695-705 (2008)


Article DOI: 10.1021/jm701129j
BindingDB Entry DOI: 10.7270/Q28K79ZW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375671
PNG
(CHEMBL429430)
Show SMILES COc1cc2nccc(Oc3ccc4N(CCOc4c3)C(=O)Nc3ccccc3)c2cc1OC
Show InChI InChI=1S/C26H23N3O5/c1-31-24-15-19-20(16-25(24)32-2)27-11-10-22(19)34-18-8-9-21-23(14-18)33-13-12-29(21)26(30)28-17-6-4-3-5-7-17/h3-11,14-16H,12-13H2,1-2H3,(H,28,30)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1695-705 (2008)


Article DOI: 10.1021/jm701129j
BindingDB Entry DOI: 10.7270/Q28K79ZW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375997
PNG
(CHEMBL272252)
Show SMILES COc1ccc2c(Oc3ccc4c(cccc4c3)C(N)=O)ccnc2c1
Show InChI InChI=1S/C21H16N2O3/c1-25-14-5-8-18-19(12-14)23-10-9-20(18)26-15-6-7-16-13(11-15)3-2-4-17(16)21(22)24/h2-12H,1H3,(H2,22,24)
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n/an/a 1.20n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


J Med Chem 51: 1668-80 (2008)


Article DOI: 10.1021/jm701098w
BindingDB Entry DOI: 10.7270/Q2F47Q0C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376009
PNG
(CHEMBL409103)
Show SMILES CCCNC(=O)c1cccc2cc(Oc3ccnc4cc(OC)c(OC)cc34)ccc12
Show InChI InChI=1S/C25H24N2O4/c1-4-11-27-25(28)19-7-5-6-16-13-17(8-9-18(16)19)31-22-10-12-26-21-15-24(30-3)23(29-2)14-20(21)22/h5-10,12-15H,4,11H2,1-3H3,(H,27,28)
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n/an/a 1.30n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


J Med Chem 51: 1668-80 (2008)


Article DOI: 10.1021/jm701098w
BindingDB Entry DOI: 10.7270/Q2F47Q0C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376000
PNG
(CHEMBL270556)
Show SMILES COc1cc2ncnc(Oc3ccc4c(cccc4c3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C21H17N3O4/c1-26-18-9-16-17(10-19(18)27-2)23-11-24-21(16)28-13-6-7-14-12(8-13)4-3-5-15(14)20(22)25/h3-11H,1-2H3,(H2,22,25)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


J Med Chem 51: 1668-80 (2008)


Article DOI: 10.1021/jm701098w
BindingDB Entry DOI: 10.7270/Q2F47Q0C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376010
PNG
(CHEMBL269871)
Show SMILES CCNC(=O)c1cccc2cc(Oc3ccnc4cc(OC)c(OC)cc34)ccc12
Show InChI InChI=1S/C24H22N2O4/c1-4-25-24(27)18-7-5-6-15-12-16(8-9-17(15)18)30-21-10-11-26-20-14-23(29-3)22(28-2)13-19(20)21/h5-14H,4H2,1-3H3,(H,25,27)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


J Med Chem 51: 1668-80 (2008)


Article DOI: 10.1021/jm701098w
BindingDB Entry DOI: 10.7270/Q2F47Q0C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50375995
PNG
(CHEMBL260532)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(N)=O)c2cc1C(N)=O
Show InChI InChI=1S/C22H17N3O4/c1-28-20-11-18-16(10-17(20)22(24)27)19(7-8-25-18)29-13-5-6-14-12(9-13)3-2-4-15(14)21(23)26/h2-11H,1H3,(H2,23,26)(H2,24,27)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


J Med Chem 51: 1668-80 (2008)


Article DOI: 10.1021/jm701098w
BindingDB Entry DOI: 10.7270/Q2F47Q0C
More data for this
Ligand-Target Pair
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