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Compile Data Set for Download or QSAR

Found 1613 hits with Last Name = 'helal' and Initial = 'cj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50398003
PNG
(CHEMBL2180402)
Show SMILES COc1ccc(cc1)-n1c(CCN2C(=O)c3cccc(OC(C)C)c3C2=O)nc2nc(C)ccc2c1=O
Show InChI InChI=1S/C28H26N4O5/c1-16(2)37-22-7-5-6-20-24(22)28(35)31(26(20)33)15-14-23-30-25-21(13-8-17(3)29-25)27(34)32(23)18-9-11-19(36-4)12-10-18/h5-13,16H,14-15H2,1-4H3
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0.100n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50398003
PNG
(CHEMBL2180402)
Show SMILES COc1ccc(cc1)-n1c(CCN2C(=O)c3cccc(OC(C)C)c3C2=O)nc2nc(C)ccc2c1=O
Show InChI InChI=1S/C28H26N4O5/c1-16(2)37-22-7-5-6-20-24(22)28(35)31(26(20)33)15-14-23-30-25-21(13-8-17(3)29-25)27(34)32(23)18-9-11-19(36-4)12-10-18/h5-13,16H,14-15H2,1-4H3
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0.100n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50398012
PNG
(CHEMBL2180422 | US8492392, 1-17)
Show SMILES CC(C)Oc1nc(nc2CCN(Cc12)S(=O)(=O)c1cccnc1)-c1ccc(Cl)nc1
Show InChI InChI=1S/C20H20ClN5O3S/c1-13(2)29-20-16-12-26(30(27,28)15-4-3-8-22-11-15)9-7-17(16)24-19(25-20)14-5-6-18(21)23-10-14/h3-6,8,10-11,13H,7,9,12H2,1-2H3
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0.630n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50398013
PNG
(CHEMBL2180421 | US8492392, K-2)
Show SMILES CC(C)Oc1nc(nc2CCN(Cc12)C(=O)Nc1cnn(C)c1)-c1ccc(Cl)nc1
Show InChI InChI=1S/C20H22ClN7O2/c1-12(2)30-19-15-11-28(20(29)24-14-9-23-27(3)10-14)7-6-16(15)25-18(26-19)13-4-5-17(21)22-8-13/h4-5,8-10,12H,6-7,11H2,1-3H3,(H,24,29)
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0.900n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50398011
PNG
(CHEMBL2180423 | US8492392, O-2)
Show SMILES COCCOc1nc(nc2CCN(Cc12)C(=O)c1cnn2ccccc12)-c1ccc(Cl)nc1
Show InChI InChI=1S/C23H21ClN6O3/c1-32-10-11-33-22-17-14-29(23(31)16-13-26-30-8-3-2-4-19(16)30)9-7-18(17)27-21(28-22)15-5-6-20(24)25-12-15/h2-6,8,12-13H,7,9-11,14H2,1H3
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0.920n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50398004
PNG
(CHEMBL2180401)
Show SMILES COc1cccc2C(=O)N(CCc3nc4ccccc4c(=O)n3-c3ccc4cnn(C)c4c3)C(=O)c12
Show InChI InChI=1S/C27H21N5O4/c1-30-21-14-17(11-10-16(21)15-28-30)32-23(29-20-8-4-3-6-18(20)26(32)34)12-13-31-25(33)19-7-5-9-22(36-2)24(19)27(31)35/h3-11,14-15H,12-13H2,1-2H3
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0.950n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50398008
PNG
(CHEMBL2180426)
Show SMILES COc1ccc(cc1)-n1c(CCN2C(=O)c3cccc(OC)c3C2=O)nc2ccccc2c1=O
Show InChI InChI=1S/C26H21N3O5/c1-33-17-12-10-16(11-13-17)29-22(27-20-8-4-3-6-18(20)25(29)31)14-15-28-24(30)19-7-5-9-21(34-2)23(19)26(28)32/h3-13H,14-15H2,1-2H3
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2n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119778
PNG
(CHEMBL2180429 | US8691827, I-9)
Show SMILES O=C(Nc1ccccc1)N1CCc2nc(nc(NCc3cnc([nH]3)-c3ccccc3)c2C1)-c1cccnc1
Show InChI InChI=1S/C29H26N8O/c38-29(34-22-11-5-2-6-12-22)37-15-13-25-24(19-37)28(36-27(35-25)21-10-7-14-30-16-21)32-18-23-17-31-26(33-23)20-8-3-1-4-9-20/h1-12,14,16-17H,13,15,18-19H2,(H,31,33)(H,34,38)(H,32,35,36)
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2.20n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
Phosphodiesterase 2A


(Rattus norvegicus)
BDBM107767
PNG
(US8598155, 2)
Show SMILES Cc1nc(-c2cnn(C)c2-c2ccc(cn2)C(F)(F)F)c2c(ncnn12)N1CCC1
Show InChI InChI=1S/C19H17F3N8/c1-11-27-15(17-18(29-6-3-7-29)24-10-26-30(11)17)13-9-25-28(2)16(13)14-5-4-12(8-23-14)19(20,21)22/h4-5,8-10H,3,6-7H2,1-2H3
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4.20n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL




J Med Chem 61: 1001-1018 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50398005
PNG
(CHEMBL2180430 | US8691827, I-8)
Show SMILES CC(C)CC(=O)N1CCc2nc(nc(N(C)Cc3ccccc3)c2C1)-c1cncc(c1)-c1cn[nH]c1
Show InChI InChI=1S/C28H31N7O/c1-19(2)11-26(36)35-10-9-25-24(18-35)28(34(3)17-20-7-5-4-6-8-20)33-27(32-25)22-12-21(13-29-14-22)23-15-30-31-16-23/h4-8,12-16,19H,9-11,17-18H2,1-3H3,(H,30,31)
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15n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50398007
PNG
(CHEMBL2180428 | US8691827, I-1)
Show SMILES O=C(Nc1ccccc1)N1CCc2nc(nc(NCCc3ccccn3)c2C1)-c1ccncc1
Show InChI InChI=1S/C26H25N7O/c34-26(30-21-7-2-1-3-8-21)33-17-12-23-22(18-33)25(29-16-11-20-6-4-5-13-28-20)32-24(31-23)19-9-14-27-15-10-19/h1-10,13-15H,11-12,16-18H2,(H,30,34)(H,29,31,32)
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48n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50398010
PNG
(CHEMBL2180424)
Show SMILES COc1ccc(cc1)-n1c(CCN2C(=O)c3ccccc3C2=O)nc2ccccc2c1=O
Show InChI InChI=1S/C25H19N3O4/c1-32-17-12-10-16(11-13-17)28-22(26-21-9-5-4-8-20(21)25(28)31)14-15-27-23(29)18-6-2-3-7-19(18)24(27)30/h2-13H,14-15H2,1H3
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87n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50088503
PNG
(CHEMBL3527048)
Show SMILES Cc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CC[C@@H](C3)N3CCCCC3)c12 |r|
Show InChI InChI=1/C26H32N8/c1-18-7-9-19(10-8-18)24-21(15-29-31(24)2)23-22-25(32(3)30-23)27-17-28-26(22)34-14-11-20(16-34)33-12-5-4-6-13-33/h7-10,15,17,20H,4-6,11-14,16H2,1-3H3/t20-/s2
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120n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of midazolam 1'-hydroxylase activity of human recombinant CYP3A4 harboring human P450 oxidoreductase and b5 assessed as decrease in enzyme...


Drug Metab Dispos 40: 1686-97 (2012)


Article DOI: 10.1124/dmd.112.045302
BindingDB Entry DOI: 10.7270/Q2GT5PW2
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50088503
PNG
(CHEMBL3527048)
Show SMILES Cc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CC[C@@H](C3)N3CCCCC3)c12 |r|
Show InChI InChI=1/C26H32N8/c1-18-7-9-19(10-8-18)24-21(15-29-31(24)2)23-22-25(32(3)30-23)27-17-28-26(22)34-14-11-20(16-34)33-12-5-4-6-13-33/h7-10,15,17,20H,4-6,11-14,16H2,1-3H3/t20-/s2
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170n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of testosterone 6beta-hydroxylase activity of human recombinant CYP3A4 in presence of human P450 oxidoreductase and b5 assessed as decreas...


Drug Metab Dispos 40: 1686-97 (2012)


Article DOI: 10.1124/dmd.112.045302
BindingDB Entry DOI: 10.7270/Q2GT5PW2
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM50398789
PNG
(CHEMBL2180073)
Show SMILES C[C@@H](N1CC(C1)Oc1ccccc1)c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1 |r|
Show InChI InChI=1S/C21H25N5O3/c1-14(25-12-17(13-25)29-16-5-3-2-4-6-16)19-23-20-18(21(27)24-19)11-22-26(20)15-7-9-28-10-8-15/h2-6,11,14-15,17H,7-10,12-13H2,1H3,(H,23,24,27)/t14-/m1/s1
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293n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DAT


J Med Chem 55: 9055-68 (2012)


Article DOI: 10.1021/jm3009635
BindingDB Entry DOI: 10.7270/Q2CR5VHK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50003985
PNG
(CHEMBL2180436)
Show SMILES O=S(=O)(N1CCOCC1)c1cccc2CCN(Cc12)c1nc(NCc2ccncc2)c2ccncc2n1
Show InChI InChI=1S/C26H27N7O3S/c34-37(35,33-12-14-36-15-13-33)24-3-1-2-20-7-11-32(18-22(20)24)26-30-23-17-28-10-6-21(23)25(31-26)29-16-19-4-8-27-9-5-19/h1-6,8-10,17H,7,11-16,18H2,(H,29,30,31)
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<1.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50003983
PNG
(CHEMBL2180435)
Show SMILES C(Oc1nc(nc2cnccc12)-c1cccc(c1)-c1ncco1)c1ccncc1
Show InChI InChI=1S/C22H15N5O2/c1-2-16(12-17(3-1)21-25-10-11-28-21)20-26-19-13-24-9-6-18(19)22(27-20)29-14-15-4-7-23-8-5-15/h1-13H,14H2
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<1.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50003984
PNG
(CHEMBL2180437)
Show SMILES COC(=O)NC1CCCN(C1)c1nc(nc2cnccc12)-c1cccc(c1)-c1cccnc1OC
Show InChI InChI=1S/C26H26N6O3/c1-34-25-20(9-4-11-28-25)17-6-3-7-18(14-17)23-30-22-15-27-12-10-21(22)24(31-23)32-13-5-8-19(16-32)29-26(33)35-2/h3-4,6-7,9-12,14-15,19H,5,8,13,16H2,1-2H3,(H,29,33)
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<1.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50003980
PNG
(CHEMBL2180434)
Show SMILES Cc1ncccc1-c1cccc(c1)-c1nc(NCc2ccncc2)c2ccncc2n1
Show InChI InChI=1S/C25H20N6/c1-17-21(6-3-10-28-17)19-4-2-5-20(14-19)24-30-23-16-27-13-9-22(23)25(31-24)29-15-18-7-11-26-12-8-18/h2-14,16H,15H2,1H3,(H,29,30,31)
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<1.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50003979
PNG
(CHEMBL2180433)
Show SMILES C(Oc1ccc(cc1)-c1cccnc1N1CCc2ncccc2C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C29H24N4O/c1-2-8-28-22(5-1)9-12-24(32-28)20-34-25-13-10-21(11-14-25)26-7-4-17-31-29(26)33-18-15-27-23(19-33)6-3-16-30-27/h1-14,16-17H,15,18-20H2
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<1.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50003981
PNG
(CHEMBL2180431)
Show SMILES COc1c(C)cc(COc2ccc(cc2)-c2cccnc2N2CCc3ncccc3C2)nc1C
Show InChI InChI=1S/C28H28N4O2/c1-19-16-23(31-20(2)27(19)33-3)18-34-24-10-8-21(9-11-24)25-7-5-14-30-28(25)32-15-12-26-22(17-32)6-4-13-29-26/h4-11,13-14,16H,12,15,17-18H2,1-3H3
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<1.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50003982
PNG
(CHEMBL2180432)
Show SMILES C(Oc1ccc(cc1)-c1cccnc1N1CCOCC1)c1ccc2ccccc2n1
Show InChI InChI=1S/C25H23N3O2/c1-2-6-24-20(4-1)7-10-21(27-24)18-30-22-11-8-19(9-12-22)23-5-3-13-26-25(23)28-14-16-29-17-15-28/h1-13H,14-18H2
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<1.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
Cytochrome P450 3A5 (CYP3A5)


(Homo sapiens (Human))
BDBM50088503
PNG
(CHEMBL3527048)
Show SMILES Cc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CC[C@@H](C3)N3CCCCC3)c12 |r|
Show InChI InChI=1/C26H32N8/c1-18-7-9-19(10-8-18)24-21(15-29-31(24)2)23-22-25(32(3)30-23)27-17-28-26(22)34-14-11-20(16-34)33-12-5-4-6-13-33/h7-10,15,17,20H,4-6,11-14,16H2,1-3H3/t20-/s2
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1.20E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of testosterone 6beta-hydroxylase activity of human recombinant CYP3A5 in presence of human P450 oxidoreductase and b5 assessed as decreas...


Drug Metab Dispos 40: 1686-97 (2012)


Article DOI: 10.1124/dmd.112.045302
BindingDB Entry DOI: 10.7270/Q2GT5PW2
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM50398807
PNG
(CHEMBL2180074)
Show SMILES CC(N1CC(C1)Oc1ccc(F)cc1)c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C21H24FN5O3/c1-13(26-11-17(12-26)30-16-4-2-14(22)3-5-16)19-24-20-18(21(28)25-19)10-23-27(20)15-6-8-29-9-7-15/h2-5,10,13,15,17H,6-9,11-12H2,1H3,(H,24,25,28)
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1.20E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DAT


J Med Chem 55: 9055-68 (2012)


Article DOI: 10.1021/jm3009635
BindingDB Entry DOI: 10.7270/Q2CR5VHK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50398009
PNG
(CHEMBL2180425)
Show SMILES COc1ccc(cc1)-n1c(CN2C(=O)c3ccccc3C2=O)nc2ccccc2c1=O
Show InChI InChI=1S/C24H17N3O4/c1-31-16-12-10-15(11-13-16)27-21(25-20-9-5-4-8-19(20)24(27)30)14-26-22(28)17-6-2-3-7-18(17)23(26)29/h2-13H,14H2,1H3
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1.90E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
Cytochrome P450 3A5 (CYP3A5)


(Homo sapiens (Human))
BDBM50088503
PNG
(CHEMBL3527048)
Show SMILES Cc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CC[C@@H](C3)N3CCCCC3)c12 |r|
Show InChI InChI=1/C26H32N8/c1-18-7-9-19(10-8-18)24-21(15-29-31(24)2)23-22-25(32(3)30-23)27-17-28-26(22)34-14-11-20(16-34)33-12-5-4-6-13-33/h7-10,15,17,20H,4-6,11-14,16H2,1-3H3/t20-/s2
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2.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of midazolam 1'-hydroxylase activity of human recombinant CYP3A5 harboring human P450 oxidoreductase and b5 assessed as decrease in enzyme...


Drug Metab Dispos 40: 1686-97 (2012)


Article DOI: 10.1124/dmd.112.045302
BindingDB Entry DOI: 10.7270/Q2GT5PW2
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM50398800
PNG
(CHEMBL2180069)
Show SMILES C[C@@H](N1CC(C1)Oc1ncccn1)c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1 |r|
Show InChI InChI=1S/C19H23N7O3/c1-12(25-10-14(11-25)29-19-20-5-2-6-21-19)16-23-17-15(18(27)24-16)9-22-26(17)13-3-7-28-8-4-13/h2,5-6,9,12-14H,3-4,7-8,10-11H2,1H3,(H,23,24,27)/t12-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DAT


J Med Chem 55: 9055-68 (2012)


Article DOI: 10.1021/jm3009635
BindingDB Entry DOI: 10.7270/Q2CR5VHK
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM50398804
PNG
(CHEMBL2177497)
Show SMILES CC(N1CC(C1)Oc1ccc(cc1)C#N)c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C22H24N6O3/c1-14(27-12-18(13-27)31-17-4-2-15(10-23)3-5-17)20-25-21-19(22(29)26-20)11-24-28(21)16-6-8-30-9-7-16/h2-5,11,14,16,18H,6-9,12-13H2,1H3,(H,25,26,29)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DAT


J Med Chem 55: 9055-68 (2012)


Article DOI: 10.1021/jm3009635
BindingDB Entry DOI: 10.7270/Q2CR5VHK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50397973
PNG
(CHEMBL2180441)
Show SMILES Cc1nc2ccc(cc2nc1\C=C\c1nc(N[C@@H]2CCS(=O)(=O)C2)cc(n1)N1CCCC1)C(F)(F)F |r|
Show InChI InChI=1S/C24H25F3N6O2S/c1-15-18(30-20-12-16(24(25,26)27)4-5-19(20)28-15)6-7-21-31-22(29-17-8-11-36(34,35)14-17)13-23(32-21)33-9-2-3-10-33/h4-7,12-13,17H,2-3,8-11,14H2,1H3,(H,29,31,32)/b7-6+/t17-/m1/s1
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n/an/a 0.00330n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM142586
PNG
(US8933224, 4)
Show SMILES COc1ccc2CCN(Cc2c1OCCF)c1ncnn2c(C)nc([C@@H]3CCOC3)c12
Show InChI InChI=1S/C22H26FN5O3/c1-14-26-19(16-6-9-30-12-16)20-22(24-13-25-28(14)20)27-8-5-15-3-4-18(29-2)21(17(15)11-27)31-10-7-23/h3-4,13,16H,5-12H2,1-2H3/t16-/m1/s1
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US Patent
n/an/a 0.0386n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM142493
PNG
(US8933224, 86)
Show SMILES CC(C)c1nn(C)c2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r|
Show InChI InChI=1/C20H27N7O/c1-12(2)17-15-9-26(7-5-16(15)25(4)24-17)20-19-18(14-6-8-28-10-14)23-13(3)27(19)22-11-21-20/h11-12,14H,5-10H2,1-4H3/t14-/s2
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n/an/a 0.0444n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50397987
PNG
(CHEMBL2180452)
Show SMILES CC(=O)N1CCCC(C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H24N4O3/c1-17(31)30-15-5-6-19(16-30)21-7-4-14-27-26(21)33-20-12-10-18(11-13-20)24(32)25-28-22-8-2-3-9-23(22)29-25/h2-4,7-14,19H,5-6,15-16H2,1H3,(H,28,29)
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n/an/a 0.0500n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142557
PNG
(US8933224, 150)
Show SMILES CCn1c(nc2CCN(Cc2c1=O)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1 |r|
Show InChI InChI=1/C22H27N7O2/c1-3-28-20(14-4-5-14)26-17-6-8-27(10-16(17)22(28)30)21-19-18(15-7-9-31-11-15)25-13(2)29(19)24-12-23-21/h12,14-15H,3-11H2,1-2H3/t15-/s2
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n/an/a 0.0697n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM142544
PNG
(US8933224, 137)
Show SMILES CCc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1 |r|
Show InChI InChI=1/C22H27N7O/c1-3-17-16-10-28(8-6-18(16)27-21(26-17)14-4-5-14)22-20-19(15-7-9-30-11-15)25-13(2)29(20)24-12-23-22/h12,14-15H,3-11H2,1-2H3/t15-/s2
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n/an/a 0.0777n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142550
PNG
(US8933224, 143 | US8933224, 144)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(C3CC3)n(C)c(=O)c2C1 |r|
Show InChI InChI=1/C21H25N7O2/c1-12-24-17(14-6-8-30-10-14)18-20(22-11-23-28(12)18)27-7-5-16-15(9-27)21(29)26(2)19(25-16)13-3-4-13/h11,13-14H,3-10H2,1-2H3/t14-/s2
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n/an/a 0.0837n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142481
PNG
(US8933224, 74)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2ccc(nc2C1)C1CC1 |r|
Show InChI InChI=1/C21H24N6O/c1-13-24-19(16-7-9-28-11-16)20-21(22-12-23-27(13)20)26-8-6-15-4-5-17(14-2-3-14)25-18(15)10-26/h4-5,12,14,16H,2-3,6-11H2,1H3/t16-/s2
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n/an/a 0.0896n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142544
PNG
(US8933224, 137)
Show SMILES CCc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1 |r|
Show InChI InChI=1/C22H27N7O/c1-3-17-16-10-28(8-6-18(16)27-21(26-17)14-4-5-14)22-20-19(15-7-9-30-11-15)25-13(2)29(20)24-12-23-22/h12,14-15H,3-11H2,1-2H3/t15-/s2
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n/an/a 0.0950n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142536
PNG
(US8933224, 129)
Show SMILES CCn1c(C)nc2CCN(Cc2c1=O)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r|
Show InChI InChI=1/C20H25N7O2/c1-4-26-12(2)23-16-5-7-25(9-15(16)20(26)28)19-18-17(14-6-8-29-10-14)24-13(3)27(18)22-11-21-19/h11,14H,4-10H2,1-3H3/t14-/s2
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n/an/a 0.0998n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50397999
PNG
(CHEMBL2180796)
Show SMILES Cn1ncc(C(=O)N2CCOCC2)c1C(=O)Nc1ccn2cc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C23H22N6O3/c1-27-21(18(14-24-27)23(31)28-9-11-32-12-10-28)22(30)25-17-7-8-29-15-19(26-20(29)13-17)16-5-3-2-4-6-16/h2-8,13-15H,9-12H2,1H3,(H,25,30)
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n/an/a 0.100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDEDA2 using [3H]cGMP as substrate after 30 mins by scintillation proximity assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50004081
PNG
(CHEMBL2180797)
Show SMILES Cn1ncc(C(=O)N2CCC2)c1C(=O)Nc1ccn2cc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C22H20N6O2/c1-26-20(17(13-23-26)22(30)27-9-5-10-27)21(29)24-16-8-11-28-14-18(25-19(28)12-16)15-6-3-2-4-7-15/h2-4,6-8,11-14H,5,9-10H2,1H3,(H,24,29)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDEDA2 using [3H]cGMP as substrate after 30 mins by scintillation proximity assay


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142459
PNG
(US8933224, 52)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(nc(O)c2C1)C1CC1 |r|
Show InChI InChI=1/C20H23N7O2/c1-11-23-16(13-5-7-29-9-13)17-19(21-10-22-27(11)17)26-6-4-15-14(8-26)20(28)25-18(24-15)12-2-3-12/h10,12-13H,2-9H2,1H3,(H,24,25,28)/t13-/s2
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n/an/a 0.101n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142451
PNG
(US8933224, 44)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nn(C)c(C3CC3)c2C1 |r|
Show InChI InChI=1/C20H25N7O/c1-12-23-17(14-6-8-28-10-14)19-20(21-11-22-27(12)19)26-7-5-16-15(9-26)18(13-3-4-13)25(2)24-16/h11,13-14H,3-10H2,1-2H3/t14-/s2
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n/an/a 0.102n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142550
PNG
(US8933224, 143 | US8933224, 144)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(C3CC3)n(C)c(=O)c2C1 |r|
Show InChI InChI=1/C21H25N7O2/c1-12-24-17(14-6-8-30-10-14)18-20(22-11-23-28(12)18)27-7-5-16-15(9-27)21(29)26(2)19(25-16)13-3-4-13/h11,13-14H,3-10H2,1-2H3/t14-/s2
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n/an/a 0.106n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM142451
PNG
(US8933224, 44)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nn(C)c(C3CC3)c2C1 |r|
Show InChI InChI=1/C20H25N7O/c1-12-23-17(14-6-8-28-10-14)19-20(21-11-22-27(12)19)26-7-5-16-15(9-26)18(13-3-4-13)25(2)24-16/h11,13-14H,3-10H2,1-2H3/t14-/s2
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Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142442
PNG
(US8933224, 35)
Show SMILES CCOc1nc(C)nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r|
Show InChI InChI=1/C20H25N7O2/c1-4-29-20-15-9-26(7-5-16(15)23-12(2)24-20)19-18-17(14-6-8-28-10-14)25-13(3)27(18)22-11-21-19/h11,14H,4-10H2,1-3H3/t14-/s2
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Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142555
PNG
(US8933224, 148)
Show SMILES CCOc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1 |r|
Show InChI InChI=1/C22H27N7O2/c1-3-31-22-16-10-28(8-6-17(16)26-20(27-22)14-4-5-14)21-19-18(15-7-9-30-11-15)25-13(2)29(19)24-12-23-21/h12,14-15H,3-11H2,1-2H3/t15-/s2
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Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142559
PNG
(US8933224, 152)
Show SMILES CNc1ccc2CN(CCc2n1)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r|
Show InChI InChI=1/C19H23N7O/c1-12-23-17(14-6-8-27-10-14)18-19(21-11-22-26(12)18)25-7-5-15-13(9-25)3-4-16(20-2)24-15/h3-4,11,14H,5-10H2,1-2H3,(H,20,24)/t14-/s2
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Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142493
PNG
(US8933224, 86)
Show SMILES CC(C)c1nn(C)c2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r|
Show InChI InChI=1/C20H27N7O/c1-12(2)17-15-9-26(7-5-16(15)25(4)24-17)20-19-18(14-6-8-28-10-14)23-13(3)27(19)22-11-21-20/h11-12,14H,5-10H2,1-4H3/t14-/s2
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Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142446
PNG
(US8933224, 173 | US8933224, 39)
Show SMILES COc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1 |r|
Show InChI InChI=1/C21H25N7O2/c1-12-24-17(14-6-8-30-10-14)18-20(22-11-23-28(12)18)27-7-5-16-15(9-27)21(29-2)26-19(25-16)13-3-4-13/h11,13-14H,3-10H2,1-2H3/t14-/s2
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Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142548
PNG
(US8933224, 141)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(nc(OC(F)F)c2C1)C1CC1 |r|
Show InChI InChI=1/C21H23F2N7O2/c1-11-26-16(13-5-7-31-9-13)17-19(24-10-25-30(11)17)29-6-4-15-14(8-29)20(32-21(22)23)28-18(27-15)12-2-3-12/h10,12-13,21H,2-9H2,1H3/t13-/s2
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n/an/a 0.142n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
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