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Compile Data Set for Download or QSAR

Found 167 hits with Last Name = 'hill' and Initial = 'rc'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-lysine methyltransferase SMYD2


(Homo sapiens (Human))
BDBM50180955
PNG
(CHEMBL3818617)
Show SMILES CCN([C@H]1CN(N=C1c1ccc(Cl)c(Cl)c1)C(\Nc1cccc(OC(F)F)c1)=N/C#N)C(=O)CO |r,c:6|
Show InChI InChI=1/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13)22(28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H,28,29)/t18-/s2
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8n/an/an/an/an/an/an/an/a



BAYER Pharma AG

Curated by ChEMBL


Assay Description
Competitive inhibition of full length 6xHis-tagged SMYD2 (unknown origin) expressed in Escherichia coli using varying levels of Btn-Ahx-GSRAHSSHLKSKK...


J Med Chem 59: 4578-600 (2016)


BindingDB Entry DOI: 10.7270/Q2RN39S5
More data for this
Ligand-Target Pair
N-lysine methyltransferase SMYD2


(Homo sapiens (Human))
BDBM50180955
PNG
(CHEMBL3818617)
Show SMILES CCN([C@H]1CN(N=C1c1ccc(Cl)c(Cl)c1)C(\Nc1cccc(OC(F)F)c1)=N/C#N)C(=O)CO |r,c:6|
Show InChI InChI=1/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13)22(28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H,28,29)/t18-/s2
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28n/an/an/an/an/an/an/an/a



BAYER Pharma AG

Curated by ChEMBL


Assay Description
Uncompetitive inhibition of full length 6xHis-tagged SMYD2 (unknown origin) expressed in Escherichia coli using fixed levels of Btn-Ahx-GSRAHSSHLKSKK...


J Med Chem 59: 4578-600 (2016)


BindingDB Entry DOI: 10.7270/Q2RN39S5
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50354578
PNG
(BUPRENORPHINE | US9315514, Buprenorphine)
Show SMILES CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45 |r|
Show InChI InChI=1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29+/m1/s1
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n/an/a 0.410n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224336
PNG
(CHEMBL1744168)
Show SMILES OC(=O)\C=C/C(O)=O.COc1ccccc1N(CC=C)C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1
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n/an/a 0.410n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224339
PNG
(CHEMBL1744167)
Show SMILES OC(=O)\C=C/C(O)=O.COc1ccccc1N(CC#C)C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1
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n/an/a 0.410n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50354578
PNG
(BUPRENORPHINE | US9315514, Buprenorphine)
Show SMILES CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45 |r|
Show InChI InChI=1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29+/m1/s1
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n/an/a 0.440n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224323
PNG
(CHEMBL1794881)
Show SMILES OC(=O)\C=C\C(O)=O.CCCN(C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1)c1ccccc1OC
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n/an/a 0.510n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224340
PNG
(CHEMBL147150)
Show SMILES CCOc1ccccc1N(CC)C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1
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n/an/a 0.550n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224323
PNG
(CHEMBL1794881)
Show SMILES OC(=O)\C=C\C(O)=O.CCCN(C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1)c1ccccc1OC
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n/an/a 0.660n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224341
PNG
(CHEMBL1744169)
Show SMILES OC(=O)\C=C/C(O)=O.CCCN(C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1)c1ccccc1OCC
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n/an/a 0.800n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224322
PNG
(CHEMBL1744170)
Show SMILES OC(=O)\C=C\C(O)=O.CCN(C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1)c1ccccc1OC
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n/an/a 0.940n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224341
PNG
(CHEMBL1744169)
Show SMILES OC(=O)\C=C/C(O)=O.CCCN(C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1)c1ccccc1OCC
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n/an/a 0.950n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224320
PNG
(CHEMBL1744186)
Show SMILES OC(=O)\C=C\C(O)=O.CCOc1ccccc1N(C)C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1
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n/an/a 0.980n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50000788
PNG
((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Show SMILES Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O |r|
Show InChI InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1
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n/an/a 1.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224340
PNG
(CHEMBL147150)
Show SMILES CCOc1ccccc1N(CC)C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1
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n/an/a 1.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50134989
PNG
(CHEMBL3746640)
Show SMILES NC(=O)c1c(Oc2cccc(CNS(N)(=O)=O)c2)cc(F)c(F)c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C20H16F3IN4O4S/c21-13-7-11(24)4-5-15(13)28-19-17(20(25)29)16(8-14(22)18(19)23)32-12-3-1-2-10(6-12)9-27-33(26,30)31/h1-8,27-28H,9H2,(H2,25,29)(H2,26,30,31)
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n/an/a 1.80n/an/an/an/an/an/a



Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 in human HeLa-MaTu matched pair cells assessed as reduction in ERK phosphorylation


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224319
PNG
(CHEMBL1744182)
Show SMILES OC(=O)\C=C/C(O)=O.CC(C(=O)N(CC=C)C1CCCCC1)C1(O)CCN(CCc2ccccc2Cl)CC1
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n/an/a 2.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224336
PNG
(CHEMBL1744168)
Show SMILES OC(=O)\C=C/C(O)=O.COc1ccccc1N(CC=C)C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1
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n/an/a 2.90n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224321
PNG
(CHEMBL1744187)
Show SMILES OC(=O)\C=C/C(O)=O.COc1ccccc1N(C)C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1
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n/an/a 3.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224339
PNG
(CHEMBL1744167)
Show SMILES OC(=O)\C=C/C(O)=O.COc1ccccc1N(CC#C)C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1
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n/an/a 4.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50000092
PNG
((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1|
Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
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n/an/a 4.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224322
PNG
(CHEMBL1744170)
Show SMILES OC(=O)\C=C\C(O)=O.CCN(C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1)c1ccccc1OC
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n/an/a 6.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224324
PNG
(CHEMBL1744191)
Show SMILES OC(=O)\C=C\C(O)=O.CCN(C(=O)C(C)(C)C1(O)CCN(CCc2ccccc2Cl)CC1)c1ccccc1OC
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n/an/a 7.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50134989
PNG
(CHEMBL3746640)
Show SMILES NC(=O)c1c(Oc2cccc(CNS(N)(=O)=O)c2)cc(F)c(F)c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C20H16F3IN4O4S/c21-13-7-11(24)4-5-15(13)28-19-17(20(25)29)16(8-14(22)18(19)23)32-12-3-1-2-10(6-12)9-27-33(26,30)31/h1-8,27-28H,9H2,(H2,25,29)(H2,26,30,31)
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n/an/a 8.70n/an/an/an/an/an/a



Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 in human HeLa-MaTu-ADR matched pair cells assessed as reduction in ERK phosphorylation


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224320
PNG
(CHEMBL1744186)
Show SMILES OC(=O)\C=C\C(O)=O.CCOc1ccccc1N(C)C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1
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n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50134978
PNG
(CHEMBL3747294)
Show SMILES CN(C)S(=O)(=O)Nc1cccc(Oc2cc(F)c(F)c(Nc3ccc(I)cc3F)c2C(N)=O)c1
Show InChI InChI=1S/C21H18F3IN4O4S/c1-29(2)34(31,32)28-12-4-3-5-13(9-12)33-17-10-15(23)19(24)20(18(17)21(26)30)27-16-7-6-11(25)8-14(16)22/h3-10,27-28H,1-2H3,(H2,26,30)
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Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysis


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50181506
PNG
(CHEMBL3819038)
Show SMILES CCN(C1CN(N=C1c1ccc(Cl)cc1)C(\NCCc1cccc(Cl)c1)=N/C#N)C(=O)CO |c:6|
Show InChI InChI=1/C23H24Cl2N6O2/c1-2-30(21(33)14-32)20-13-31(29-22(20)17-6-8-18(24)9-7-17)23(28-15-26)27-11-10-16-4-3-5-19(25)12-16/h3-9,12,20,32H,2,10-11,13-14H2,1H3,(H,27,28)
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BAYER Pharma AG

Curated by ChEMBL


Assay Description
Antagonist activity at PAR1 (unknown origin)


J Med Chem 59: 4578-600 (2016)


BindingDB Entry DOI: 10.7270/Q2RN39S5
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50134968
PNG
(CHEMBL3746569)
Show SMILES NCCS(=O)(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1
Show InChI InChI=1S/C21H19F2IN4O4S/c22-12-8-18(27-17-5-4-13(24)10-16(17)23)20(21(26)29)19(9-12)32-15-3-1-2-14(11-15)28-33(30,31)7-6-25/h1-5,8-11,27-28H,6-7,25H2,(H2,26,29)
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Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysis


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50000788
PNG
((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Show SMILES Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O |r|
Show InChI InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1
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TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50134971
PNG
(CHEMBL3747066)
Show SMILES CCS(=O)(=O)Nc1cccc(Oc2cc(F)c(F)c(Nc3ccc(I)cc3F)c2C(N)=O)c1
Show InChI InChI=1S/C21H17F3IN3O4S/c1-2-33(30,31)28-12-4-3-5-13(9-12)32-17-10-15(23)19(24)20(18(17)21(26)29)27-16-7-6-11(25)8-14(16)22/h3-10,27-28H,2H2,1H3,(H2,26,29)
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Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysis


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50134976
PNG
(CHEMBL3746736)
Show SMILES NC(=O)c1c(Oc2cccc(NS(N)(=O)=O)c2)cc(F)c(F)c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C19H14F3IN4O4S/c20-12-6-9(23)4-5-14(12)26-18-16(19(24)28)15(8-13(21)17(18)22)31-11-3-1-2-10(7-11)27-32(25,29)30/h1-8,26-27H,(H2,24,28)(H2,25,29,30)
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Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysis


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM104963
PNG
(CHEMBL507361 | US8575391, Q)
Show SMILES OC[C@@H](O)CONC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F |r|
Show InChI InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
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Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysis


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50001028
PNG
((+)-PENTAZOCINE | (-)-pentazocine | (2R,6R,11R)-6,...)
Show SMILES [#6]-[#6@H]1-[#6@H]-2-[#6]-c3ccc(-[#8])cc3[C@]1([#6])[#6]-[#6]-[#7]-2-[#6]\[#6]=[#6](\[#6])-[#6] |r,TLB:16:15:1:3.4.10|
Show InChI InChI=1S/C19H27NO/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19/h5-7,12,14,18,21H,8-11H2,1-4H3/t14-,18+,19+/m0/s1
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TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50134986
PNG
(CHEMBL3746559)
Show SMILES NC(=O)c1c(Oc2ccc(F)c(NS(N)(=O)=O)c2)cc(F)c(F)c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C19H13F4IN4O4S/c20-10-3-2-9(6-14(10)28-33(26,30)31)32-15-7-12(22)17(23)18(16(15)19(25)29)27-13-4-1-8(24)5-11(13)21/h1-7,27-28H,(H2,25,29)(H2,26,30,31)
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Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysis


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50355497
PNG
(AZD-6244 | CHEMBL1614701)
Show SMILES Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO
Show InChI InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
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Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 in human HeLa-MaTu matched pair cells assessed as reduction in ERK phosphorylation


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50135016
PNG
(CHEMBL3747047)
Show SMILES Cc1c(NS(N)(=O)=O)cccc1Oc1cc(F)c(F)c(Nc2ccc(I)cc2F)c1C(N)=O
Show InChI InChI=1S/C20H16F3IN4O4S/c1-9-13(28-33(26,30)31)3-2-4-15(9)32-16-8-12(22)18(23)19(17(16)20(25)29)27-14-6-5-10(24)7-11(14)21/h2-8,27-28H,1H3,(H2,25,29)(H2,26,30,31)
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Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysis


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50134925
PNG
(CHEMBL2376666)
Show SMILES NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1cccc(NS(N)(=O)=O)c1
Show InChI InChI=1S/C19H15F2IN4O4S/c20-10-6-16(25-15-5-4-11(22)8-14(15)21)18(19(23)27)17(7-10)30-13-3-1-2-12(9-13)26-31(24,28)29/h1-9,25-26H,(H2,23,27)(H2,24,28,29)
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Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysis


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50134938
PNG
(CHEMBL3747256)
Show SMILES Cc1c(NS(N)(=O)=O)cccc1Oc1cc(F)cc(Nc2ccc(I)cc2F)c1C(N)=O
Show InChI InChI=1S/C20H17F2IN4O4S/c1-10-14(27-32(25,29)30)3-2-4-17(10)31-18-8-11(21)7-16(19(18)20(24)28)26-15-6-5-12(23)9-13(15)22/h2-9,26-27H,1H3,(H2,24,28)(H2,25,29,30)
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Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysis


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50134927
PNG
(CHEMBL3747136)
Show SMILES CCNS(=O)(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1
Show InChI InChI=1S/C21H19F2IN4O4S/c1-2-26-33(30,31)28-14-4-3-5-15(11-14)32-19-9-12(22)8-18(20(19)21(25)29)27-17-7-6-13(24)10-16(17)23/h3-11,26-28H,2H2,1H3,(H2,25,29)
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Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysis


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
N-lysine methyltransferase SMYD2


(Homo sapiens (Human))
BDBM50075102
PNG
(CHEMBL3414623)
Show SMILES Cc1cn(CCN2CCN(CC2)c2ccccc2-c2cc(cc(c2)C(=O)NCCCN2CCCC2)C#N)c2ccccc12
Show InChI InChI=1S/C36H42N6O/c1-28-27-42(34-11-4-2-9-32(28)34)22-19-40-17-20-41(21-18-40)35-12-5-3-10-33(35)30-23-29(26-37)24-31(25-30)36(43)38-13-8-16-39-14-6-7-15-39/h2-5,9-12,23-25,27H,6-8,13-22H2,1H3,(H,38,43)
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BAYER Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of SMYD2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using Biotinaminohexanoyl-GSRAHSSHLKSKKGQSTSRH as substrate after 75 mi...


J Med Chem 59: 4578-600 (2016)


BindingDB Entry DOI: 10.7270/Q2RN39S5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50134973
PNG
(CHEMBL3746467)
Show SMILES CCS(=O)(=O)Nc1cccc(Oc2c(F)c(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1
Show InChI InChI=1S/C21H17F3IN3O4S/c1-2-33(30,31)28-12-4-3-5-13(9-12)32-20-18(21(26)29)17(10-15(23)19(20)24)27-16-7-6-11(25)8-14(16)22/h3-10,27-28H,2H2,1H3,(H2,26,29)
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Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysis


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50134939
PNG
(CHEMBL3747359)
Show SMILES NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1Oc1cccc(NS(N)(=O)=O)c1Cl
Show InChI InChI=1S/C19H14ClF2IN4O4S/c20-18-13(27-32(25,29)30)2-1-3-15(18)31-16-7-9(21)6-14(17(16)19(24)28)26-12-5-4-10(23)8-11(12)22/h1-8,26-27H,(H2,24,28)(H2,25,29,30)
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Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysis


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
SET and MYND domain-containing protein 2 (SMYD2)


(Homo sapiens (Human))
BDBM50180967
PNG
(CHEMBL3818487)
Show SMILES CCN([C@H]1CN(N=C1c1ccc(Cl)c(Cl)c1)C(\Nc1cc(F)cc(OC(F)F)c1)=N/C#N)C(=O)CO |r,c:6|
Show InChI InChI=1/C22H19Cl2F3N6O3/c1-2-32(19(35)10-34)18-9-33(31-20(18)12-3-4-16(23)17(24)5-12)22(29-11-28)30-14-6-13(25)7-15(8-14)36-21(26)27/h3-8,18,21,34H,2,9-10H2,1H3,(H,29,30)/t18-/s2
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BAYER Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of SMYD2 (unknown origin) using H4 as substrate after 2hrs in presence 3H-SAM of by scintillation proximity assay


J Med Chem 59: 4578-600 (2016)


BindingDB Entry DOI: 10.7270/Q2RN39S5
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50224319
PNG
(CHEMBL1744182)
Show SMILES OC(=O)\C=C/C(O)=O.CC(C(=O)N(CC=C)C1CCCCC1)C1(O)CCN(CCc2ccccc2Cl)CC1
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TBA

Curated by ChEMBL




J Med Chem 26: 42-50 (1983)


BindingDB Entry DOI: 10.7270/Q23X88VD
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50134989
PNG
(CHEMBL3746640)
Show SMILES NC(=O)c1c(Oc2cccc(CNS(N)(=O)=O)c2)cc(F)c(F)c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C20H16F3IN4O4S/c21-13-7-11(24)4-5-15(13)28-19-17(20(25)29)16(8-14(22)18(19)23)32-12-3-1-2-10(6-12)9-27-33(26,30)31/h1-8,27-28H,9H2,(H2,25,29)(H2,26,30,31)
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Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysis


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50134926
PNG
(CHEMBL2376663)
Show SMILES CN(C)S(=O)(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1
Show InChI InChI=1S/C21H19F2IN4O4S/c1-28(2)33(30,31)27-14-4-3-5-15(11-14)32-19-9-12(22)8-18(20(19)21(25)29)26-17-7-6-13(24)10-16(17)23/h3-11,26-27H,1-2H3,(H2,25,29)
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n/an/a 21n/an/an/an/an/an/a



Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysis


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50134996
PNG
(CHEMBL3746031)
Show SMILES NC(=O)c1c(Oc2cccc(CS(N)(=O)=O)c2)cc(F)c(F)c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C20H15F3IN3O4S/c21-13-7-11(24)4-5-15(13)27-19-17(20(25)28)16(8-14(22)18(19)23)31-12-3-1-2-10(6-12)9-32(26,29)30/h1-8,27H,9H2,(H2,25,28)(H2,26,29,30)
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n/an/a 22n/an/an/an/an/an/a



Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysis


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
N-lysine methyltransferase SMYD2


(Homo sapiens (Human))
BDBM50180955
PNG
(CHEMBL3818617)
Show SMILES CCN([C@H]1CN(N=C1c1ccc(Cl)c(Cl)c1)C(\Nc1cccc(OC(F)F)c1)=N/C#N)C(=O)CO |r,c:6|
Show InChI InChI=1/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13)22(28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H,28,29)/t18-/s2
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n/an/a 27n/an/an/an/an/an/a



BAYER Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of full length 6xHis-tagged SMYD2 (unknown origin) expressed in Escherichia coli using Btn-Ahx GSRAHSSHLKSKKGQSTSRH-amide as substrate aft...


J Med Chem 59: 4578-600 (2016)


BindingDB Entry DOI: 10.7270/Q2RN39S5
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50135003
PNG
(CHEMBL3746103)
Show SMILES NC(=O)c1c(Oc2ccc(F)c(NS(N)(=O)=O)c2F)cc(F)c(F)c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C19H12F5IN4O4S/c20-8-2-4-12(16(24)17(8)29-34(27,31)32)33-13-6-10(22)15(23)18(14(13)19(26)30)28-11-3-1-7(25)5-9(11)21/h1-6,28-29H,(H2,26,30)(H2,27,31,32)
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n/an/a 28n/an/an/an/an/an/a



Bayer HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysis


Bioorg Med Chem Lett 26: 186-93 (2015)


BindingDB Entry DOI: 10.7270/Q26M38NN
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50181502
PNG
(CHEMBL3818510)
Show SMILES CCN(C1CN(N=C1c1ccc(Cl)cc1)C(\Nc1ccc(Cl)c(Cl)c1)=N/C#N)C(=O)COC |c:6|
Show InChI InChI=1/C22H21Cl3N6O2/c1-3-30(20(32)12-33-2)19-11-31(29-21(19)14-4-6-15(23)7-5-14)22(27-13-26)28-16-8-9-17(24)18(25)10-16/h4-10,19H,3,11-12H2,1-2H3,(H,27,28)
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BAYER Pharma AG

Curated by ChEMBL


Assay Description
Antagonist activity at PAR1 (unknown origin)


J Med Chem 59: 4578-600 (2016)


BindingDB Entry DOI: 10.7270/Q2RN39S5
More data for this
Ligand-Target Pair
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