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Compile Data Set for Download or QSAR

Found 3378 hits with Last Name = 'hoffman' and Initial = 'j'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299749
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OCC3(CC3)C#N)nc(n2)C(=O)NC23CC(C2)C3)c1
PDB

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US Patent
0.0100n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299975
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OCC3(CC3)C#N)nc(n2)C(=O)NC2(C)CCC2)c1
PDB

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0.0120n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299902
PNG
(6-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES C[C@H](CO)NC(=O)c1nc(OC[C@H]2CCCO2)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1 |r|
PDB

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0.0120n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300077
PNG
(N-(3-amino-3- methylbutan- 2-yl)-2- (cyclo- propyl...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3cc(nc(OCC4CC4)n3)C(=O)NC(C)C(C)(C)N)c12
PDB

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<0.0130n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300011
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES C[C@H](NC(=O)c1nc(OCC2CC2)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1)C(F)(F)F |r|
PDB

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<0.0130n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300035
PNG
(2-(benzyloxy)-N- [(2R)-1- hydroxypropan-2- yl]-6-[...)
Show SMILES COc1ccnc2[nH]nc(C3CCN(CC3)c3cc(nc(OCc4ccccc4)n3)C(=O)N[C@H](C)CO)c12 |r|
PDB

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<0.0130n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300079
PNG
(N-[(2R)-1- hydroxypropan-2- yl]-6-[4-(4- methoxy-1...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3cc(nc(OC[C@H]4CCCO4)n3)C(=O)N[C@H](C)CO)c12 |r|
PDB

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<0.0130n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300088
PNG
(N-[(2R)-1- hydroxypropan-2- yl]-2-[(2R)-2- methoxy...)
Show SMILES CO[C@H](C)COc1nc(cc(n1)C(=O)N[C@H](C)CO)N1CCC(CC1)c1c[nH]c2nccc(OC)c12 |r|
PDB

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0.0140n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299998
PNG
(N-[(2R)-1- hydroxypropan-2- yl]-6-[4-(4- methoxy-1...)
Show SMILES COc1ccnc2[nH]nc(C3CCN(CC3)c3cc(nc(OC[C@H]4CCCO4)n3)C(=O)N[C@H](C)CO)c12 |r|
PDB

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0.0150n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299931
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES CC(C)NC(=O)c1nc(OC[C@H]2CC2(F)F)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1 |r|
PDB

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0.0150n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299909
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES C[C@H](NC(=O)c1nc(OC[C@H]2CCCO2)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1)C(F)(F)F |r|
PDB

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0.0160n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299744
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OCC3(CC3)C#N)nc(n2)C(=O)NC2CCC2)c1
PDB

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0.0160n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300012
PNG
(N-(2- methoxyethyl)-6- [4-(4-methoxy-1H- pyrrolo[2...)
Show SMILES COCCNC(=O)c1cc(nc(OC[C@H]2CCCO2)n1)N1CCC(CC1)c1c[nH]c2nccc(OC)c12 |r|
PDB

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0.0160n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300049
PNG
((3,3- difluoroazetidin-1- yl)(2-{[(2R)-1- methoxyp...)
Show SMILES COC[C@@H](C)Oc1nc(cc(n1)C(=O)N1CC(F)(F)C1)N1CCC(CC1)c1c[nH]c2nccc(OC)c12 |r|
PDB

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0.0180n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300007
PNG
(2-[(1- cyanocyclopropyl) methoxy]-N-[(2R)- 1-hydro...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3cc(nc(OCC4(CC4)C#N)n3)C(=O)N[C@H](C)CO)c12 |r|
PDB

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<0.0180n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299893
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES C[C@@H](NC(=O)c1nc(OCC2(CC2)C#N)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1)C1CC1 |r|
PDB

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0.0190n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS


(Homo sapiens (Human))
BDBM50018830
PNG
(CHEMBL3286830)
Show SMILES C[C@H]1Oc2cc(cnc2N)-c2c(CN(C)C(=O)c3ccc(F)cc13)nn(C)c2C#N |r|
Show InChI InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1
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CHEMBL
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UniChem
Article
PubMed
<0.0200n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROS1 (unknown origin) by off-chip mobility shift assay


J Med Chem 57: 4720-44 (2014)


Article DOI: 10.1021/jm500261q
BindingDB Entry DOI: 10.7270/Q2K35W68
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50018836
PNG
(CHEMBL3286826)
Show SMILES COc1nn(C)c2CN(C)C(=O)c3ccc(F)cc3[C@@H](C)Oc3nc(cnc3N)-c12 |r|
Show InChI InChI=1S/C20H21FN6O3/c1-10-13-7-11(21)5-6-12(13)20(28)26(2)9-15-16(18(29-4)25-27(15)3)14-8-23-17(22)19(24-14)30-10/h5-8,10H,9H2,1-4H3,(H2,22,23)/t10-/m1/s1
PDB

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<0.0200n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant ALK L1196M mutant kinase domain (amino acids 1093 to 1141) expressed in baculovirus system using 5'FAM-KKSRGDYMTMQIG-...


J Med Chem 57: 4720-44 (2014)


Article DOI: 10.1021/jm500261q
BindingDB Entry DOI: 10.7270/Q2K35W68
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300090
PNG
(N-[(2R)-1- hydroxypropan-2- yl]-2-[(2S)-2- methoxy...)
Show SMILES CO[C@@H](C)COc1nc(cc(n1)C(=O)N[C@H](C)CO)N1CCC(CC1)c1c[nH]c2nccc(OC)c12 |r|
PDB

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0.0200n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300070
PNG
(N-[(2R)-3- hydroxy-3- methylbutan-2-yl]- 4-[4-(4-m...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3nc(OC[C@H]4CCCO4)nc(n3)C(=O)N[C@H](C)C(C)(C)O)c12 |r|
PDB

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0.0200n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS


(Homo sapiens (Human))
BDBM50448785
PNG
(CHEMBL3128069)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1sc(nc1C)[C@](C)(O)CO)c1cc(F)ccc1-n1nccn1 |r|
Show InChI InChI=1S/C22H23FN6O3S/c1-12-19(33-21(28-12)22(3,31)11-30)14-8-18(20(24)25-10-14)32-13(2)16-9-15(23)4-5-17(16)29-26-6-7-27-29/h4-10,13,30-31H,11H2,1-3H3,(H2,24,25)/t13-,22-/m1/s1
PDB

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Article
PubMed
0.0200n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROS1 (unknown origin) by Pfizer mobility shift assay


J Med Chem 57: 1170-87 (2014)


Article DOI: 10.1021/jm401805h
BindingDB Entry DOI: 10.7270/Q29C6ZX5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299917
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OCC3(CC3)C#N)nc(n2)C(=O)NC(C)(C)C)c1
PDB

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0.0200n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299901
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OC[C@H]3C[C@H]3C#N)nc(n2)C(=O)NC(C)(C)C)c1 |r|
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0.0210n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300125
PNG
(N-cyclobutyl-4- {[(2R)-1- methoxypropan-2- yl]oxy}...)
Show SMILES COC[C@@H](C)Oc1nc(nc(n1)C(=O)NC1CCC1)N1CCC(CC1)c1n[nH]c2nccc(OC)c12 |r|
PDB

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0.0210n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299996
PNG
(4-[(1- cyanocyclopropyl) methoxy]-6-[4-(4- methoxy...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3nc(OCC4(CC4)C#N)nc(n3)C(=O)N[C@@H](C)C(F)(F)F)c12 |r|
PDB

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0.0210n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Rattus norvegicus)
BDBM50230127
PNG
(CHEMBL407606)
Show SMILES CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1 |wU:45.57,31.44,63.79,23.28,5.4,88.94,wD:57.63,77.91,12.20,(27.09,-8.95,;27.47,-10.44,;28.96,-10.86,;30.04,-11.96,;31.53,-11.6,;29.61,-13.45,;30.56,-14.67,;29.69,-15.95,;28.21,-15.53,;28.16,-13.97,;26.88,-13.11,;26.98,-11.58,;25.49,-13.78,;25.38,-15.33,;26.66,-16.2,;26.55,-17.73,;27.83,-18.59,;27.72,-20.13,;29,-21,;26.33,-20.8,;24.22,-12.92,;22.82,-13.6,;22.72,-15.13,;21.54,-12.73,;21.65,-11.2,;23.05,-10.52,;24.32,-11.38,;23.15,-8.98,;20.15,-13.41,;18.89,-12.55,;18.99,-11.01,;17.49,-13.23,;17.39,-14.76,;18.14,-16.08,;19.64,-16.43,;19.78,-17.94,;18.38,-18.56,;17.91,-20.01,;16.43,-20.33,;15.39,-19.17,;15.88,-17.73,;17.36,-17.42,;16.22,-12.36,;14.83,-13.03,;14.71,-14.57,;13.55,-12.17,;13.66,-10.62,;15.04,-9.95,;15.16,-8.42,;16.54,-7.74,;17.82,-8.6,;19.2,-7.93,;17.71,-10.14,;16.32,-10.81,;12.16,-12.85,;10.88,-11.97,;10.99,-10.44,;9.49,-12.65,;9.39,-14.19,;10.67,-15.06,;8.21,-11.79,;6.83,-12.46,;6.71,-14.01,;5.54,-11.6,;5.65,-10.07,;7.05,-9.39,;8.58,-9.18,;8.85,-7.67,;7.49,-6.93,;7.12,-5.44,;5.63,-5,;4.53,-6.07,;4.89,-7.56,;6.37,-8,;4.17,-12.27,;2.88,-11.41,;3,-9.87,;1.49,-12.09,;1.38,-13.62,;2.15,-14.95,;3.66,-14.95,;4.41,-16.27,;3.65,-17.59,;2.12,-17.59,;1.37,-16.26,;.22,-11.23,;-1.18,-11.9,;-1.28,-13.44,;-2.34,-11.11,;-2.34,-9.69,;-3.87,-9.46,;-4.55,-10.83,;-6.06,-11.09,;-3.45,-11.92,)|
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PC sid
UniChem
PubMed
0.0245n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL




J Med Chem 35: 3890-4 (1992)


BindingDB Entry DOI: 10.7270/Q24Q7X6M
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300104
PNG
(4-(benzyloxy)-N- [(2R)-1- hydroxypropan-2- yl]-6-[...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3nc(OCc4ccccc4)nc(n3)C(=O)N[C@H](C)CO)c12 |r|
PDB

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US Patent
0.0250n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299891
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES CC[C@@H](C)NC(=O)c1nc(OCC2(CC2)C#N)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1 |r|
PDB

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0.0260n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299746
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OC[C@H]3C[C@H]3C#N)nc(n2)C(=O)NC23CC(C2)C3)c1 |r|
PDB

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0.0280n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299890
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OCC3(CC3)C#N)nc(n2)C(=O)NCC(C)(C)C)c1
PDB

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0.0280n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300064
PNG
(N-[(2R)-1- hydroxypropan-2- yl]-4-{[(2R)-1- methox...)
Show SMILES COC[C@@H](C)Oc1nc(nc(n1)C(=O)N[C@H](C)CO)N1CCC(CC1)c1c[nH]c2nccc(OC)c12 |r|
PDB

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0.0280n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299930
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES C[C@H](CO)NC(=O)c1nc(OC[C@H]2CC2(F)F)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1 |r|
PDB

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0.0290n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300071
PNG
(N-[(2R)-1- hydroxypropan-2- yl]-4-[4-(4- methoxy-1...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3nc(OC[C@H]4CCCO4)nc(n3)C(=O)N[C@H](C)CO)c12 |r|
PDB

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0.0300n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299803
PNG
(N- (bicyclo[1.1.1]pent- 1-yl)-4-{[(1S,2R)- 2- cyan...)
Show SMILES COc1ccnc2[nH]nc(C3CCN(CC3)c3nc(OC[C@H]4C[C@H]4C#N)nc(n3)C(=O)NC34CC(C3)C4)c12 |r|
PDB

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0.0300n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300103
PNG
(4-[(1- cyanocyclopropyl) methoxy]-N-[(2R)- 1-hydro...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3nc(OCC4(CC4)C#N)nc(n3)C(=O)N[C@H](C)CO)c12 |r|
PDB

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0.0300n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299852
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OCC3(CC3)C#N)nc(n2)C(=O)NCC2CC2)c1
PDB

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0.0320n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300099
PNG
(4-{[(1S,2R)-2- cyanocyclopropyl] methoxy}-N-[(2R)-...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3nc(OC[C@H]4C[C@H]4C#N)nc(n3)C(=O)N[C@H](C)C(C)(C)O)c12 |r|
PDB

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0.0320n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299922
PNG
(6-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES C[C@H](CO)NC(=O)c1cc(nc(OC[C@@H]2CC2(F)F)n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1 |r|
PDB

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0.0330n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300056
PNG
(N-(3-amino-3- methylbutan-2-yl)- 2-{[(2R)-1- metho...)
Show SMILES COC[C@@H](C)Oc1nc(cc(n1)C(=O)NC(C)C(C)(C)N)N1CCC(CC1)c1c[nH]c2nccc(OC)c12 |r|
PDB

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0.0340n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300087
PNG
(N-[(1R,2R)-2- hydroxy- cyclobutyl]- 6-[4-(4-methox...)
Show SMILES COc1ccnc2[nH]nc(C3CCN(CC3)c3cc(nc(OC[C@H]4CCCO4)n3)C(=O)N[C@@H]3CC[C@H]3O)c12 |r|
PDB

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0.0340n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299911
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES C[C@@H](NC(=O)c1nc(OC[C@H]2CCCO2)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1)C(C)(C)O |r|
PDB

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0.0340n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300098
PNG
(4-{[(1S,2R)-2- cyanocyclopropyl] methoxy}-N-[(2R)-...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3nc(OC[C@H]4C[C@H]4C#N)nc(n3)C(=O)N[C@H](C)CO)c12 |r|
PDB

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0.0350n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300101
PNG
(4-(benzyloxy)-N- [(2R)-1- hydroxypropan-2- yl]-6-[...)
Show SMILES COc1ccnc2[nH]nc(C3CCN(CC3)c3nc(OCc4ccccc4)nc(n3)C(=O)N[C@H](C)CO)c12 |r|
PDB

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0.0370n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300102
PNG
(4-[(1- cyanocyclopropyl) methoxy]-N-[(2R)- 3-hydro...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3nc(OCC4(CC4)C#N)nc(n3)C(=O)N[C@H](C)C(C)(C)O)c12 |r|
PDB

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0.0380n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300063
PNG
(N-[(2R)-3- hydroxy-3- methylbutan-2-yl]- 4-{[(2R)-...)
Show SMILES COC[C@@H](C)Oc1nc(nc(n1)C(=O)N[C@H](C)C(C)(C)O)N1CCC(CC1)c1c[nH]c2nccc(OC)c12 |r|
PDB

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0.0380n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299849
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OCC3(CC3)C#N)nc(n2)C(=O)NCC(F)(F)F)c1
PDB

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0.0390n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300061
PNG
(N-(3-amino-3- methylbutan-2-yl)- 2-[(1- cyanocyclo...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3cc(nc(OCC4(CC4)C#N)n3)C(=O)NC(C)C(C)(C)N)c12
PDB

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0.0400n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299876
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES CC(NC(=O)c1nc(OCC2(CC2)C#N)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1)C(C)(F)F
PDB

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0.0400n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM300065
PNG
((trans)-N-(2- hydroxy- cyclobutyl)- 2-{[(2R)-1- me...)
Show SMILES COC[C@@H](C)Oc1nc(cc(n1)C(=O)NC1CCC1O)N1CCC(CC1)c1n[nH]c2nccc(OC)c12 |r|
PDB

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0.0410n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299851
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES CC(C)NC(=O)c1nc(OCC2(CC2)C#N)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1
PDB

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0.0420n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
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