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Compile Data Set for Download or QSAR

Found 64 hits with Last Name = 'hunter' and Initial = 'rc'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169371
PNG
(1-[4-(3'-Cyano-biphenyl-4-yl)-1-cyclopropylmethyl-...)
Show SMILES Clc1cc(Cl)cc(NC(=O)NCC2(CCN(CC3CC3)CC2)c2ccc(cc2)-c2cccc(c2)C#N)c1
Show InChI InChI=1S/C30H30Cl2N4O/c31-26-15-27(32)17-28(16-26)35-29(37)34-20-30(10-12-36(13-11-30)19-21-4-5-21)25-8-6-23(7-9-25)24-3-1-2-22(14-24)18-33/h1-3,6-9,14-17,21H,4-5,10-13,19-20H2,(H2,34,35,37)
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0.170n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169377
PNG
(1-[4-(3'-Cyano-biphenyl-4-yl)-1-propyl-piperidin-4...)
Show SMILES CCCN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C29H30Cl2N4O/c1-2-12-35-13-10-29(11-14-35,20-33-28(36)34-27-17-25(30)16-26(31)18-27)24-8-6-22(7-9-24)23-5-3-4-21(15-23)19-32/h3-9,15-18H,2,10-14,20H2,1H3,(H2,33,34,36)
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0.310n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169374
PNG
(1-[4-(3'-Cyano-biphenyl-4-yl)-1-(2-methoxy-ethyl)-...)
Show SMILES COCCN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C29H30Cl2N4O2/c1-37-14-13-35-11-9-29(10-12-35,20-33-28(36)34-27-17-25(30)16-26(31)18-27)24-7-5-22(6-8-24)23-4-2-3-21(15-23)19-32/h2-8,15-18H,9-14,20H2,1H3,(H2,33,34,36)
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0.410n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169390
PNG
(1-[4-(3'-Cyano-biphenyl-4-yl)-1-isopropyl-piperidi...)
Show SMILES CC(C)N1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C29H30Cl2N4O/c1-20(2)35-12-10-29(11-13-35,19-33-28(36)34-27-16-25(30)15-26(31)17-27)24-8-6-22(7-9-24)23-5-3-4-21(14-23)18-32/h3-9,14-17,20H,10-13,19H2,1-2H3,(H2,33,34,36)
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0.450n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169389
PNG
(1-[4-(3'-Cyano-biphenyl-4-yl)-1-cyclopentyl-piperi...)
Show SMILES Clc1cc(Cl)cc(NC(=O)NCC2(CCN(CC2)C2CCCC2)c2ccc(cc2)-c2cccc(c2)C#N)c1
Show InChI InChI=1S/C31H32Cl2N4O/c32-26-17-27(33)19-28(18-26)36-30(38)35-21-31(12-14-37(15-13-31)29-6-1-2-7-29)25-10-8-23(9-11-25)24-5-3-4-22(16-24)20-34/h3-5,8-11,16-19,29H,1-2,6-7,12-15,21H2,(H2,35,36,38)
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0.630n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168805
PNG
(1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-buty...)
Show SMILES CN(C)CCC(CNC(=O)Nc1ccc(F)c(F)c1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C26H26F2N4O/c1-32(2)13-12-22(17-30-26(33)31-23-10-11-24(27)25(28)15-23)20-8-6-19(7-9-20)21-5-3-4-18(14-21)16-29/h3-11,14-15,22H,12-13,17H2,1-2H3,(H2,30,31,33)
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0.840n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168812
PNG
(1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-buty...)
Show SMILES CN(C)CCC(CNC(=O)Nc1cc(F)cc(F)c1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C26H26F2N4O/c1-32(2)11-10-22(17-30-26(33)31-25-14-23(27)13-24(28)15-25)20-8-6-19(7-9-20)21-5-3-4-18(12-21)16-29/h3-9,12-15,22H,10-11,17H2,1-2H3,(H2,30,31,33)
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0.880n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169393
PNG
(1-(4-Chloro-3-trifluoromethyl-phenyl)-3-[4-(3'-cya...)
Show SMILES CN1CCC(CNC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)(CC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C28H26ClF3N4O/c1-36-13-11-27(12-14-36,22-7-5-20(6-8-22)21-4-2-3-19(15-21)17-33)18-34-26(37)35-23-9-10-25(29)24(16-23)28(30,31)32/h2-10,15-16H,11-14,18H2,1H3,(H2,34,35,37)
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0.980n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168825
PNG
(1-(3-Chloro-4-fluoro-phenyl)-3-[2-(3'-cyano-biphen...)
Show SMILES CN(C)CCC(CNC(=O)Nc1ccc(F)c(Cl)c1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C26H26ClFN4O/c1-32(2)13-12-22(17-30-26(33)31-23-10-11-25(28)24(27)15-23)20-8-6-19(7-9-20)21-5-3-4-18(14-21)16-29/h3-11,14-15,22H,12-13,17H2,1-2H3,(H2,30,31,33)
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0.980n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168791
PNG
(1-(3-Chloro-phenyl)-3-[2-(3'-cyano-biphenyl-4-yl)-...)
Show SMILES CN(C)CCC(CNC(=O)Nc1cccc(Cl)c1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C26H27ClN4O/c1-31(2)14-13-23(18-29-26(32)30-25-8-4-7-24(27)16-25)21-11-9-20(10-12-21)22-6-3-5-19(15-22)17-28/h3-12,15-16,23H,13-14,18H2,1-2H3,(H2,29,30,32)
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1.10n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168800
PNG
(1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-buty...)
Show SMILES CN(C)CCC(CNC(=O)Nc1cccc(F)c1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C26H27FN4O/c1-31(2)14-13-23(18-29-26(32)30-25-8-4-7-24(27)16-25)21-11-9-20(10-12-21)22-6-3-5-19(15-22)17-28/h3-12,15-16,23H,13-14,18H2,1-2H3,(H2,29,30,32)
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1.20n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169382
PNG
(1-[4-(3'-Cyano-biphenyl-4-yl)-1-cyclohexyl-piperid...)
Show SMILES Clc1cc(Cl)cc(NC(=O)NCC2(CCN(CC2)C2CCCCC2)c2ccc(cc2)-c2cccc(c2)C#N)c1
Show InChI InChI=1S/C32H34Cl2N4O/c33-27-18-28(34)20-29(19-27)37-31(39)36-22-32(13-15-38(16-14-32)30-7-2-1-3-8-30)26-11-9-24(10-12-26)25-6-4-5-23(17-25)21-35/h4-6,9-12,17-20,30H,1-3,7-8,13-16,22H2,(H2,36,37,39)
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1.20n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169396
PNG
(1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4...)
Show SMILES CN1CCC(CNC(=O)Nc2ccc(F)c(F)c2)(CC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C27H26F2N4O/c1-33-13-11-27(12-14-33,18-31-26(34)32-23-9-10-24(28)25(29)16-23)22-7-5-20(6-8-22)21-4-2-3-19(15-21)17-30/h2-10,15-16H,11-14,18H2,1H3,(H2,31,32,34)
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1.40n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169376
PNG
(1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4...)
Show SMILES CN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C27H26Cl2N4O/c1-33-11-9-27(10-12-33,18-31-26(34)32-25-15-23(28)14-24(29)16-25)22-7-5-20(6-8-22)21-4-2-3-19(13-21)17-30/h2-8,13-16H,9-12,18H2,1H3,(H2,31,32,34)
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1.40n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169386
PNG
(1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4...)
Show SMILES CN1CCC(CNC(=O)Nc2cccc(c2)C#N)(CC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C28H27N5O/c1-33-14-12-28(13-15-33,20-31-27(34)32-26-7-3-5-22(17-26)19-30)25-10-8-23(9-11-25)24-6-2-4-21(16-24)18-29/h2-11,16-17H,12-15,20H2,1H3,(H2,31,32,34)
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1.5n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169387
PNG
(CHEMBL366703 | N-(4'-{4-[3-(3,5-Dichloro-phenyl)-u...)
Show SMILES CN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccc(NC(C)=O)c1
Show InChI InChI=1S/C28H30Cl2N4O2/c1-19(35)32-25-5-3-4-21(14-25)20-6-8-22(9-7-20)28(10-12-34(2)13-11-28)18-31-27(36)33-26-16-23(29)15-24(30)17-26/h3-9,14-17H,10-13,18H2,1-2H3,(H,32,35)(H2,31,33,36)
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2.10n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169388
PNG
(1-(3,5-Dichloro-phenyl)-3-[1-methanesulfonyl-4-(4-...)
Show SMILES CS(=O)(=O)N1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C25H26Cl2N4O3S/c1-35(33,34)31-11-8-25(9-12-31,17-29-24(32)30-23-14-21(26)13-22(27)15-23)20-6-4-18(5-7-20)19-3-2-10-28-16-19/h2-7,10,13-16H,8-9,11-12,17H2,1H3,(H2,29,30,32)
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2.20n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169398
PNG
(1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4...)
Show SMILES CN1CCC(CNC(=O)Nc2ccccc2)(CC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C27H28N4O/c1-31-16-14-27(15-17-31,20-29-26(32)30-25-8-3-2-4-9-25)24-12-10-22(11-13-24)23-7-5-6-21(18-23)19-28/h2-13,18H,14-17,20H2,1H3,(H2,29,30,32)
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2.20n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168823
PNG
(1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-buty...)
Show SMILES CN(C)CCC(CNC(=O)Nc1ccccc1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C26H28N4O/c1-30(2)16-15-24(19-28-26(31)29-25-9-4-3-5-10-25)22-13-11-21(12-14-22)23-8-6-7-20(17-23)18-27/h3-14,17,24H,15-16,19H2,1-2H3,(H2,28,29,31)
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2.40n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168802
PNG
(1-[2-(3'-Cyano-biphenyl-4-yl)-4-methylamino-butyl]...)
Show SMILES CNCCC(CNC(=O)Nc1cc(Cl)cc(Cl)c1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C25H24Cl2N4O/c1-29-10-9-21(16-30-25(32)31-24-13-22(26)12-23(27)14-24)19-7-5-18(6-8-19)20-4-2-3-17(11-20)15-28/h2-8,11-14,21,29H,9-10,16H2,1H3,(H2,30,31,32)
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2.60n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169392
PNG
(1-[4-(3'-Chloro-biphenyl-4-yl)-1-methyl-piperidin-...)
Show SMILES CN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccc(Cl)c1
Show InChI InChI=1S/C26H26Cl3N3O/c1-32-11-9-26(10-12-32,17-30-25(33)31-24-15-22(28)14-23(29)16-24)20-7-5-18(6-8-20)19-3-2-4-21(27)13-19/h2-8,13-16H,9-12,17H2,1H3,(H2,30,31,33)
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2.60n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169370
PNG
(1-[4-(3'-Cyano-biphenyl-4-yl)-1-ethyl-piperidin-4-...)
Show SMILES CCN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C28H28Cl2N4O/c1-2-34-12-10-28(11-13-34,19-32-27(35)33-26-16-24(29)15-25(30)17-26)23-8-6-21(7-9-23)22-5-3-4-20(14-22)18-31/h3-9,14-17H,2,10-13,19H2,1H3,(H2,32,33,35)
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2.60n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168810
PNG
(1-[2-(3'-Cyano-biphenyl-4-yl)-4-cyclopentylamino-b...)
Show SMILES Clc1cc(Cl)cc(NC(=O)NCC(CCNC2CCCC2)c2ccc(cc2)-c2cccc(c2)C#N)c1
Show InChI InChI=1S/C29H30Cl2N4O/c30-25-15-26(31)17-28(16-25)35-29(36)34-19-24(12-13-33-27-6-1-2-7-27)22-10-8-21(9-11-22)23-5-3-4-20(14-23)18-32/h3-5,8-11,14-17,24,27,33H,1-2,6-7,12-13,19H2,(H2,34,35,36)
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3n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169391
PNG
(1-(3,5-Dichloro-phenyl)-3-[1-methyl-4-(4-pyridin-3...)
Show SMILES CN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C25H26Cl2N4O/c1-31-11-8-25(9-12-31,17-29-24(32)30-23-14-21(26)13-22(27)15-23)20-6-4-18(5-7-20)19-3-2-10-28-16-19/h2-7,10,13-16H,8-9,11-12,17H2,1H3,(H2,29,30,32)
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3.10n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168810
PNG
(1-[2-(3'-Cyano-biphenyl-4-yl)-4-cyclopentylamino-b...)
Show SMILES Clc1cc(Cl)cc(NC(=O)NCC(CCNC2CCCC2)c2ccc(cc2)-c2cccc(c2)C#N)c1
Show InChI InChI=1S/C29H30Cl2N4O/c30-25-15-26(31)17-28(16-25)35-29(36)34-19-24(12-13-33-27-6-1-2-7-27)22-10-8-21(9-11-22)23-5-3-4-20(14-23)18-32/h3-5,8-11,14-17,24,27,33H,1-2,6-7,12-13,19H2,(H2,34,35,36)
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4n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168799
PNG
(1-[2-(3'-Cyano-biphenyl-4-yl)-4-ethylamino-butyl]-...)
Show SMILES CCNCCC(CNC(=O)Nc1cc(Cl)cc(Cl)c1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C26H26Cl2N4O/c1-2-30-11-10-22(17-31-26(33)32-25-14-23(27)13-24(28)15-25)20-8-6-19(7-9-20)21-5-3-4-18(12-21)16-29/h3-9,12-15,22,30H,2,10-11,17H2,1H3,(H2,31,32,33)
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4.30n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168797
PNG
(1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-buty...)
Show SMILES CN(C)CCC(CNC(=O)Nc1cc(Cl)cc(Cl)c1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C26H26Cl2N4O/c1-32(2)11-10-22(17-30-26(33)31-25-14-23(27)13-24(28)15-25)20-8-6-19(7-9-20)21-5-3-4-18(12-21)16-29/h3-9,12-15,22H,10-11,17H2,1-2H3,(H2,30,31,33)
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4.70n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169372
PNG
(1-(3,5-Dichloro-phenyl)-3-[4-(3'-formyl-biphenyl-4...)
Show SMILES CN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccc(C=O)c1
Show InChI InChI=1S/C27H27Cl2N3O2/c1-32-11-9-27(10-12-32,18-30-26(34)31-25-15-23(28)14-24(29)16-25)22-7-5-20(6-8-22)21-4-2-3-19(13-21)17-33/h2-8,13-17H,9-12,18H2,1H3,(H2,30,31,34)
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5.5n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168809
PNG
(1-[2-(3'-Cyano-biphenyl-4-yl)-4-isopropylamino-but...)
Show SMILES CC(C)NCCC(CNC(=O)Nc1cc(Cl)cc(Cl)c1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C27H28Cl2N4O/c1-18(2)31-11-10-23(17-32-27(34)33-26-14-24(28)13-25(29)15-26)21-8-6-20(7-9-21)22-5-3-4-19(12-22)16-30/h3-9,12-15,18,23,31H,10-11,17H2,1-2H3,(H2,32,33,34)
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5.60n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168814
PNG
(1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-buty...)
Show SMILES CN(C)CCC(CNC(=O)Nc1ccc(F)cc1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C26H27FN4O/c1-31(2)15-14-23(18-29-26(32)30-25-12-10-24(27)11-13-25)21-8-6-20(7-9-21)22-5-3-4-19(16-22)17-28/h3-13,16,23H,14-15,18H2,1-2H3,(H2,29,30,32)
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7.40n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168804
PNG
(1-(4-Chloro-phenyl)-3-[2-(3'-cyano-biphenyl-4-yl)-...)
Show SMILES CN(C)CCC(CNC(=O)Nc1ccc(Cl)cc1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C26H27ClN4O/c1-31(2)15-14-23(18-29-26(32)30-25-12-10-24(27)11-13-25)21-8-6-20(7-9-21)22-5-3-4-19(16-22)17-28/h3-13,16,23H,14-15,18H2,1-2H3,(H2,29,30,32)
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9.20n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169395
PNG
(1-[1-Butyl-4-(3'-cyano-biphenyl-4-yl)-piperidin-4-...)
Show SMILES CCCCN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C30H32Cl2N4O/c1-2-3-13-36-14-11-30(12-15-36,21-34-29(37)35-28-18-26(31)17-27(32)19-28)25-9-7-23(8-10-25)24-6-4-5-22(16-24)20-33/h4-10,16-19H,2-3,11-15,21H2,1H3,(H2,34,35,37)
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11n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169381
PNG
(1-[4-(3'-Cyano-biphenyl-4-yl)-1-cyclobutyl-piperid...)
Show SMILES Clc1cc(Cl)cc(NC(=O)NCC2(CCN(CC2)C2CCC2)c2ccc(cc2)-c2cccc(c2)C#N)c1
Show InChI InChI=1S/C30H30Cl2N4O/c31-25-16-26(32)18-27(17-25)35-29(37)34-20-30(11-13-36(14-12-30)28-5-2-6-28)24-9-7-22(8-10-24)23-4-1-3-21(15-23)19-33/h1,3-4,7-10,15-18,28H,2,5-6,11-14,20H2,(H2,34,35,37)
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11n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169394
PNG
(1-[1-sec-Butyl-4-(3'-cyano-biphenyl-4-yl)-piperidi...)
Show SMILES CCC(C)N1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C30H32Cl2N4O/c1-3-21(2)36-13-11-30(12-14-36,20-34-29(37)35-28-17-26(31)16-27(32)18-28)25-9-7-23(8-10-25)24-6-4-5-22(15-24)19-33/h4-10,15-18,21H,3,11-14,20H2,1-2H3,(H2,34,35,37)
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13n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168821
PNG
(1-[4-Cyclopentylamino-2-(3'-trifluoromethoxy-biphe...)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1ccc(cc1)C(CCNC1CCCC1)CNC(=O)Nc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C29H30Cl2F3N3O2/c30-23-15-24(31)17-26(16-23)37-28(38)36-18-22(12-13-35-25-5-1-2-6-25)20-10-8-19(9-11-20)21-4-3-7-27(14-21)39-29(32,33)34/h3-4,7-11,14-17,22,25,35H,1-2,5-6,12-13,18H2,(H2,36,37,38)
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20n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168811
PNG
(1-[4-Cyclopentylamino-2-(4-pyridin-3-yl-phenyl)-bu...)
Show SMILES Clc1cc(Cl)cc(NC(=O)NCC(CCNC2CCCC2)c2ccc(cc2)-c2cccnc2)c1
Show InChI InChI=1S/C27H30Cl2N4O/c28-23-14-24(29)16-26(15-23)33-27(34)32-18-22(11-13-31-25-5-1-2-6-25)20-9-7-19(8-10-20)21-4-3-12-30-17-21/h3-4,7-10,12,14-17,22,25,31H,1-2,5-6,11,13,18H2,(H2,32,33,34)
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24n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168792
PNG
(1-[2-(3'-Chloro-biphenyl-4-yl)-4-cyclopentylamino-...)
Show SMILES Clc1cccc(c1)-c1ccc(cc1)C(CCNC1CCCC1)CNC(=O)Nc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C28H30Cl3N3O/c29-23-5-3-4-21(14-23)19-8-10-20(11-9-19)22(12-13-32-26-6-1-2-7-26)18-33-28(35)34-27-16-24(30)15-25(31)17-27/h3-5,8-11,14-17,22,26,32H,1-2,6-7,12-13,18H2,(H2,33,34,35)
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26n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168815
PNG
(1-[4-Cyclopentylamino-2-(3'-fluoro-biphenyl-4-yl)-...)
Show SMILES Fc1cccc(c1)-c1ccc(cc1)C(CCNC1CCCC1)CNC(=O)Nc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C28H30Cl2FN3O/c29-23-15-24(30)17-27(16-23)34-28(35)33-18-22(12-13-32-26-6-1-2-7-26)20-10-8-19(9-11-20)21-4-3-5-25(31)14-21/h3-5,8-11,14-17,22,26,32H,1-2,6-7,12-13,18H2,(H2,33,34,35)
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37n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169373
PNG
(1-(3,5-Dichloro-phenyl)-3-[4-(4-pyridin-3-yl-pheny...)
Show SMILES Clc1cc(Cl)cc(NC(=O)NCC2(CCNCC2)c2ccc(cc2)-c2cccnc2)c1
Show InChI InChI=1S/C24H24Cl2N4O/c25-20-12-21(26)14-22(13-20)30-23(31)29-16-24(7-10-27-11-8-24)19-5-3-17(4-6-19)18-2-1-9-28-15-18/h1-6,9,12-15,27H,7-8,10-11,16H2,(H2,29,30,31)
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39n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168824
PNG
(1-[2-(4'-Cyano-biphenyl-4-yl)-4-cyclopentylamino-b...)
Show SMILES Clc1cc(Cl)cc(NC(=O)NCC(CCNC2CCCC2)c2ccc(cc2)-c2ccc(cc2)C#N)c1
Show InChI InChI=1S/C29H30Cl2N4O/c30-25-15-26(31)17-28(16-25)35-29(36)34-19-24(13-14-33-27-3-1-2-4-27)23-11-9-22(10-12-23)21-7-5-20(18-32)6-8-21/h5-12,15-17,24,27,33H,1-4,13-14,19H2,(H2,34,35,36)
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46n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168798
PNG
(1-(2-Biphenyl-4-yl-4-cyclopentylamino-butyl)-3-(3,...)
Show SMILES Clc1cc(Cl)cc(NC(=O)NCC(CCNC2CCCC2)c2ccc(cc2)-c2ccccc2)c1
Show InChI InChI=1S/C28H31Cl2N3O/c29-24-16-25(30)18-27(17-24)33-28(34)32-19-23(14-15-31-26-8-4-5-9-26)22-12-10-21(11-13-22)20-6-2-1-3-7-20/h1-3,6-7,10-13,16-18,23,26,31H,4-5,8-9,14-15,19H2,(H2,32,33,34)
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50n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169380
PNG
(4-[3-(3,5-Dichloro-phenyl)-ureidomethyl]-4-(4-pyri...)
Show SMILES CN(C)S(=O)(=O)N1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C26H29Cl2N5O3S/c1-32(2)37(35,36)33-12-9-26(10-13-33,18-30-25(34)31-24-15-22(27)14-23(28)16-24)21-7-5-19(6-8-21)20-4-3-11-29-17-20/h3-8,11,14-17H,9-10,12-13,18H2,1-2H3,(H2,30,31,34)
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84n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169384
PNG
(1-(2-Fluoro-phenyl)-3-[1-(1-methyl-1H-benzoimidazo...)
Show SMILES Cn1c(CN2CCC(CNC(=O)Nc3ccccc3F)(CC2)c2ccc(cc2)-c2cccnc2)nc2ccccc12
Show InChI InChI=1S/C33H33FN6O/c1-39-30-11-5-4-10-29(30)37-31(39)22-40-19-16-33(17-20-40,23-36-32(41)38-28-9-3-2-8-27(28)34)26-14-12-24(13-15-26)25-7-6-18-35-21-25/h2-15,18,21H,16-17,19-20,22-23H2,1H3,(H2,36,38,41)
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98n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168817
PNG
(1-[4-[1,4']Bipiperidinyl-1'-yl-2-(3,4-dichloro-phe...)
Show SMILES Fc1ccc(NC(=O)NCC(CCN2CCC(CC2)N2CCCCC2)c2ccc(Cl)c(Cl)c2)cc1Cl
Show InChI InChI=1S/C27H34Cl3FN4O/c28-23-6-4-19(16-24(23)29)20(18-32-27(36)33-21-5-7-26(31)25(30)17-21)8-13-34-14-9-22(10-15-34)35-11-2-1-3-12-35/h4-7,16-17,20,22H,1-3,8-15,18H2,(H2,32,33,36)
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100n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168801
PNG
(1-[4-Cyclopentylamino-2-(4-pyridin-4-yl-phenyl)-bu...)
Show SMILES Clc1cc(Cl)cc(NC(=O)NCC(CCNC2CCCC2)c2ccc(cc2)-c2ccncc2)c1
Show InChI InChI=1S/C27H30Cl2N4O/c28-23-15-24(29)17-26(16-23)33-27(34)32-18-22(11-14-31-25-3-1-2-4-25)20-7-5-19(6-8-20)21-9-12-30-13-10-21/h5-10,12-13,15-17,22,25,31H,1-4,11,14,18H2,(H2,32,33,34)
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122n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168820
PNG
(1-[2-(2'-Chloro-biphenyl-4-yl)-4-cyclopentylamino-...)
Show SMILES Clc1cc(Cl)cc(NC(=O)NCC(CCNC2CCCC2)c2ccc(cc2)-c2ccccc2Cl)c1
Show InChI InChI=1S/C28H30Cl3N3O/c29-22-15-23(30)17-25(16-22)34-28(35)33-18-21(13-14-32-24-5-1-2-6-24)19-9-11-20(12-10-19)26-7-3-4-8-27(26)31/h3-4,7-12,15-17,21,24,32H,1-2,5-6,13-14,18H2,(H2,33,34,35)
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130n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50168793
PNG
(1-[4-[1,4']Bipiperidinyl-1'-yl-2-(3,4-dichloro-phe...)
Show SMILES Clc1cc(Cl)cc(NC(=O)NCC(CCN2CCC(CC2)N2CCCCC2)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C27H34Cl4N4O/c28-21-15-22(29)17-23(16-21)33-27(36)32-18-20(19-4-5-25(30)26(31)14-19)6-11-34-12-7-24(8-13-34)35-9-2-1-3-10-35/h4-5,14-17,20,24H,1-3,6-13,18H2,(H2,32,33,36)
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135n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibitiory constant towards Human melanin-concentrating hormone receptor


Bioorg Med Chem Lett 15: 3691-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.039
BindingDB Entry DOI: 10.7270/Q2X066KC
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169397
PNG
(1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4...)
Show SMILES CN1CCC(CNC(=O)Nc2cc(Cl)ccc2Cl)(CC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C27H26Cl2N4O/c1-33-13-11-27(12-14-33,18-31-26(34)32-25-16-23(28)9-10-24(25)29)22-7-5-20(6-8-22)21-4-2-3-19(15-21)17-30/h2-10,15-16H,11-14,18H2,1H3,(H2,31,32,34)
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140n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169378
PNG
(3,5-Dichloro-N-[4-(3'-cyano-biphenyl-4-yl)-1-methy...)
Show SMILES CN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C27H25Cl2N3O/c1-32-11-9-27(10-12-32,18-31-26(33)22-14-24(28)16-25(29)15-22)23-7-5-20(6-8-23)21-4-2-3-19(13-21)17-30/h2-8,13-16H,9-12,18H2,1H3,(H,31,33)
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155n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50169383
PNG
(CHEMBL178549 | N-[4-(3'-Cyano-biphenyl-4-yl)-1-met...)
Show SMILES CN1CCC(CNC(=O)Cc2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C28H27Cl2N3O/c1-33-11-9-28(10-12-33,19-32-27(34)16-21-14-25(29)17-26(30)15-21)24-7-5-22(6-8-24)23-4-2-3-20(13-23)18-31/h2-8,13-15,17H,9-12,16,19H2,1H3,(H,32,34)
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164n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery, Inc.

Curated by ChEMBL


Assay Description
Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cells


Bioorg Med Chem Lett 15: 3696-700 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.085
BindingDB Entry DOI: 10.7270/Q2ZS2W16
More data for this
Ligand-Target Pair
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