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Compile Data Set for Download or QSAR

Found 64 hits with Last Name = 'imase' and Initial = 'h'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase WNK1


(Homo sapiens (Human))
BDBM50258546
PNG
(CHEMBL4087727)
PDB
MMDB

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32n/an/an/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.

Curated by ChEMBL




J Med Chem 60: 7099-7107 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00708
More data for this
Ligand-Target Pair
With-No-Lysine (K) Kinase 2 (WNK2)


(Homo sapiens (Human))
BDBM203827
PNG
(N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...)
Show SMILES CC(C)(C)NC(=O)c1cncn1C1CCN(CC1)c1ccc(cc1)-c1nnc(o1)C(F)(F)F
Show InChI InChI=1S/C22H25F3N6O2/c1-21(2,3)27-18(32)17-12-26-13-31(17)16-8-10-30(11-9-16)15-6-4-14(5-7-15)19-28-29-20(33-19)22(23,24)25/h4-7,12-13,16H,8-11H2,1-3H3,(H,27,32)
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n/an/a 1n/an/an/an/a7.325



Novartis Institutes



Assay Description
Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...


Nat Chem Biol 12: 896-898 (2016)


Article DOI: 10.1038/nchembio.2168
BindingDB Entry DOI: 10.7270/Q2ZK5FH5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WNK1


(Homo sapiens (Human))
BDBM50258566
PNG
(CHEMBL4088706)
PDB
MMDB

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n/an/a 4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.

Curated by ChEMBL




J Med Chem 60: 7099-7107 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00708
More data for this
Ligand-Target Pair
With-No-Lysine (K) Kinase 1 (WNK1)


(Homo sapiens (Human))
BDBM203827
PNG
(N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...)
Show SMILES CC(C)(C)NC(=O)c1cncn1C1CCN(CC1)c1ccc(cc1)-c1nnc(o1)C(F)(F)F
Show InChI InChI=1S/C22H25F3N6O2/c1-21(2,3)27-18(32)17-12-26-13-31(17)16-8-10-30(11-9-16)15-6-4-14(5-7-15)19-28-29-20(33-19)22(23,24)25/h4-7,12-13,16H,8-11H2,1-3H3,(H,27,32)
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n/an/a 5n/an/an/an/a7.325



Novartis Institutes



Assay Description
Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...


Nat Chem Biol 12: 896-898 (2016)


Article DOI: 10.1038/nchembio.2168
BindingDB Entry DOI: 10.7270/Q2ZK5FH5
More data for this
Ligand-Target Pair
With-No-Lysine (K) Kinase 3 (WNK3)


(Homo sapiens (Human))
BDBM203827
PNG
(N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...)
Show SMILES CC(C)(C)NC(=O)c1cncn1C1CCN(CC1)c1ccc(cc1)-c1nnc(o1)C(F)(F)F
Show InChI InChI=1S/C22H25F3N6O2/c1-21(2,3)27-18(32)17-12-26-13-31(17)16-8-10-30(11-9-16)15-6-4-14(5-7-15)19-28-29-20(33-19)22(23,24)25/h4-7,12-13,16H,8-11H2,1-3H3,(H,27,32)
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n/an/a 6n/an/an/an/a7.325



Novartis Institutes



Assay Description
Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...


Nat Chem Biol 12: 896-898 (2016)


Article DOI: 10.1038/nchembio.2168
BindingDB Entry DOI: 10.7270/Q2ZK5FH5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WNK1


(Homo sapiens (Human))
BDBM50258547
PNG
(CHEMBL4098876)
PDB
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n/an/a 6n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.

Curated by ChEMBL




J Med Chem 60: 7099-7107 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00708
More data for this
Ligand-Target Pair
With-No-Lysine (K) Kinase 4 (WNK4)


(Homo sapiens (Human))
BDBM203827
PNG
(N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...)
Show SMILES CC(C)(C)NC(=O)c1cncn1C1CCN(CC1)c1ccc(cc1)-c1nnc(o1)C(F)(F)F
Show InChI InChI=1S/C22H25F3N6O2/c1-21(2,3)27-18(32)17-12-26-13-31(17)16-8-10-30(11-9-16)15-6-4-14(5-7-15)19-28-29-20(33-19)22(23,24)25/h4-7,12-13,16H,8-11H2,1-3H3,(H,27,32)
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n/an/a 9n/an/an/an/a7.325



Novartis Institutes



Assay Description
Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...


Nat Chem Biol 12: 896-898 (2016)


Article DOI: 10.1038/nchembio.2168
BindingDB Entry DOI: 10.7270/Q2ZK5FH5
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50312718
PNG
(CHEMBL479527 | torcetrapib)
Show SMILES CCOC(=O)N1[C@H](CC)C[C@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)OC)c2cc(ccc12)C(F)(F)F |r|
Show InChI InChI=1S/C26H25F9N2O4/c1-4-18-12-21(19-11-15(24(27,28)29)6-7-20(19)37(18)23(39)41-5-2)36(22(38)40-3)13-14-8-16(25(30,31)32)10-17(9-14)26(33,34)35/h6-11,18,21H,4-5,12-13H2,1-3H3/t18-,21+/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc.

Curated by ChEMBL




J Med Chem 60: 8466-8481 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00900
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50348228
PNG
(CHEMBL1800807)
Show SMILES COc1cc(F)c(cc1-c1ccc(cc1CN1[C@@H](C)[C@H](OC1=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(F)(F)F)C(C)C |r|
Show InChI InChI=1S/C30H25F10NO3/c1-14(2)22-11-23(25(43-4)12-24(22)31)21-6-5-18(28(32,33)34)9-17(21)13-41-15(3)26(44-27(41)42)16-7-19(29(35,36)37)10-20(8-16)30(38,39)40/h5-12,14-15,26H,13H2,1-4H3/t15-,26-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc.

Curated by ChEMBL




J Med Chem 60: 8466-8481 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00900
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124871
PNG
(US8759365, 9-4 | US8759365, 9-5)
Show SMILES CCC(C)OC(=O)N1C[C@H](C[C@H]1CC)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C28H32F6N6O2/c1-5-17(3)42-26(41)40-16-24(10-23(40)6-2)39(25-35-11-19(12-36-25)20-13-37-38(4)15-20)14-18-7-21(27(29,30)31)9-22(8-18)28(32,33)34/h7-9,11-13,15,17,23-24H,5-6,10,14,16H2,1-4H3/t17?,23-,24+/m1/s1
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n/an/a 21n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124882
PNG
(US8759365, 6)
Show SMILES CC[C@@H]1C[C@@H](CN1C(=O)OC(C)C)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C27H30F6N6O2/c1-5-22-9-23(15-39(22)25(40)41-16(2)3)38(24-34-10-18(11-35-24)19-12-36-37(4)14-19)13-17-6-20(26(28,29)30)8-21(7-17)27(31,32)33/h6-8,10-12,14,16,22-23H,5,9,13,15H2,1-4H3/t22-,23+/m1/s1
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n/an/a 23n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124884
PNG
(US8759365, 16-2)
Show SMILES CC[C@H]1C[C@H](CN1C(=O)N1CCCCC1)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1
Show InChI InChI=1S/C29H33F6N7O/c1-3-24-12-25(18-42(24)27(43)40-7-5-4-6-8-40)41(26-36-13-20(14-37-26)21-15-38-39(2)17-21)16-19-9-22(28(30,31)32)11-23(10-19)29(33,34)35/h9-11,13-15,17,24-25H,3-8,12,16,18H2,1-2H3/t24-,25+/m0/s1
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n/an/a 25n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124878
PNG
(US8759365, 23-10)
Show SMILES CC[C@@H]1C[C@@H](CN1c1nc(ncc1Cl)N1CCC(O)CC1)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C32H34ClF6N9O/c1-3-24-11-25(18-47(24)28-27(33)15-42-30(44-28)46-6-4-26(49)5-7-46)48(29-40-12-20(13-41-29)21-14-43-45(2)17-21)16-19-8-22(31(34,35)36)10-23(9-19)32(37,38)39/h8-10,12-15,17,24-26,49H,3-7,11,16,18H2,1-2H3/t24-,25+/m1/s1
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n/an/a 30n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124876
PNG
(US8759365, 17)
Show SMILES CC[C@@H]1C[C@@H](CN1C(=O)N1CCOCC1)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1
Show InChI InChI=1S/C28H31F6N7O2/c1-3-23-11-24(17-41(23)26(42)39-4-6-43-7-5-39)40(25-35-12-19(13-36-25)20-14-37-38(2)16-20)15-18-8-21(27(29,30)31)10-22(9-18)28(32,33)34/h8-10,12-14,16,23-24H,3-7,11,15,17H2,1-2H3/t23-,24+/m1/s1
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n/an/a 32n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124881
PNG
(US8759365, 14)
Show SMILES CC[C@@H]1C[C@@H](CN1C(=O)OC(C)C)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cn[nH]c1
Show InChI InChI=1S/C26H28F6N6O2/c1-4-21-8-22(14-38(21)24(39)40-15(2)3)37(23-33-9-17(10-34-23)18-11-35-36-12-18)13-16-5-19(25(27,28)29)7-20(6-16)26(30,31)32/h5-7,9-12,15,21-22H,4,8,13-14H2,1-3H3,(H,35,36)/t21-,22+/m1/s1
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n/an/a 34n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124875
PNG
(US8759365, 16)
Show SMILES CC[C@@H]1C[C@@H](CN1C(=O)N1CCCC1)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1
Show InChI InChI=1S/C28H31F6N7O/c1-3-23-11-24(17-41(23)26(42)39-6-4-5-7-39)40(25-35-12-19(13-36-25)20-14-37-38(2)16-20)15-18-8-21(27(29,30)31)10-22(9-18)28(32,33)34/h8-10,12-14,16,23-24H,3-7,11,15,17H2,1-2H3/t23-,24+/m1/s1
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n/an/a 39n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WNK1


(Homo sapiens (Human))
BDBM50258598
PNG
(CHEMBL4091128)
PDB
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n/an/a 39n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.

Curated by ChEMBL




J Med Chem 60: 7099-7107 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00708
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124868
PNG
(US8759365, 9-1)
Show SMILES CCC(CC)OC(=O)N1C[C@H](C[C@H]1CC)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C29H34F6N6O2/c1-5-23-11-24(17-41(23)27(42)43-25(6-2)7-3)40(26-36-12-19(13-37-26)20-14-38-39(4)16-20)15-18-8-21(28(30,31)32)10-22(9-18)29(33,34)35/h8-10,12-14,16,23-25H,5-7,11,15,17H2,1-4H3/t23-,24+/m1/s1
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n/an/a 41n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
With-No-Lysine (K) Kinase 1 (WNK1)


(Homo sapiens (Human))
BDBM203827
PNG
(N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...)
Show SMILES CC(C)(C)NC(=O)c1cncn1C1CCN(CC1)c1ccc(cc1)-c1nnc(o1)C(F)(F)F
Show InChI InChI=1S/C22H25F3N6O2/c1-21(2,3)27-18(32)17-12-26-13-31(17)16-8-10-30(11-9-16)15-6-4-14(5-7-15)19-28-29-20(33-19)22(23,24)25/h4-7,12-13,16H,8-11H2,1-3H3,(H,27,32)
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n/an/a 41n/an/an/an/a7.34



Novartis Institutes



Assay Description
Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...


Nat Chem Biol 12: 896-898 (2016)


Article DOI: 10.1038/nchembio.2168
BindingDB Entry DOI: 10.7270/Q2ZK5FH5
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124867
PNG
(US8759365, 7-6)
Show SMILES CC[C@@H]1C[C@@H](CN1C(=O)OCC1CCOCC1)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C30H34F6N6O3/c1-3-25-11-26(17-42(25)28(43)45-18-19-4-6-44-7-5-19)41(27-37-12-21(13-38-27)22-14-39-40(2)16-22)15-20-8-23(29(31,32)33)10-24(9-20)30(34,35)36/h8-10,12-14,16,19,25-26H,3-7,11,15,17-18H2,1-2H3/t25-,26+/m1/s1
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n/an/a 46n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124865
PNG
(US8759365, 6-2)
Show SMILES CC[C@@H]1C[C@@H](CN1C(=O)OCC(C)(C)C)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C29H34F6N6O2/c1-6-23-10-24(16-41(23)26(42)43-17-27(2,3)4)40(25-36-11-19(12-37-25)20-13-38-39(5)15-20)14-18-7-21(28(30,31)32)9-22(8-18)29(33,34)35/h7-9,11-13,15,23-24H,6,10,14,16-17H2,1-5H3/t23-,24+/m1/s1
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n/an/a 47n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124883
PNG
(US8759365, 9)
Show SMILES CC[C@@H]1C[C@@H](CN1C(=O)OCC1(C)COC1)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C29H32F6N6O3/c1-4-23-8-24(14-41(23)26(42)44-17-27(2)15-43-16-27)40(25-36-9-19(10-37-25)20-11-38-39(3)13-20)12-18-5-21(28(30,31)32)7-22(6-18)29(33,34)35/h5-7,9-11,13,23-24H,4,8,12,14-17H2,1-3H3/t23-,24+/m1/s1
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n/an/a 53n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124871
PNG
(US8759365, 9-4 | US8759365, 9-5)
Show SMILES CCC(C)OC(=O)N1C[C@H](C[C@H]1CC)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C28H32F6N6O2/c1-5-17(3)42-26(41)40-16-24(10-23(40)6-2)39(25-35-11-19(12-36-25)20-13-37-38(4)15-20)14-18-7-21(27(29,30)31)9-22(8-18)28(32,33)34/h7-9,11-13,15,17,23-24H,5-6,10,14,16H2,1-4H3/t17?,23-,24+/m1/s1
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n/an/a 54n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124869
PNG
(US8759365, 9-2)
Show SMILES CC[C@@H]1C[C@@H](CN1C(=O)OCC(F)(F)F)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C26H25F9N6O2/c1-3-20-7-21(13-41(20)23(42)43-14-24(27,28)29)40(22-36-8-16(9-37-22)17-10-38-39(2)12-17)11-15-4-18(25(30,31)32)6-19(5-15)26(33,34)35/h4-6,8-10,12,20-21H,3,7,11,13-14H2,1-2H3/t20-,21+/m1/s1
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n/an/a 59n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WNK1


(Homo sapiens (Human))
BDBM50258595
PNG
(CHEMBL4065531)
PDB
MMDB

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n/an/a 60n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.

Curated by ChEMBL




J Med Chem 60: 7099-7107 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00708
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50250371
PNG
(CHEMBL4064793)
PDB
MMDB

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n/an/a 60n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc.

Curated by ChEMBL




J Med Chem 60: 8466-8481 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00900
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124866
PNG
(US8759365, 7-4)
Show SMILES CC[C@@H]1C[C@@H](CN1C(=O)OC1CCOCC1)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C29H32F6N6O3/c1-3-23-11-24(17-41(23)27(42)44-25-4-6-43-7-5-25)40(26-36-12-19(13-37-26)20-14-38-39(2)16-20)15-18-8-21(28(30,31)32)10-22(9-18)29(33,34)35/h8-10,12-14,16,23-25H,3-7,11,15,17H2,1-2H3/t23-,24+/m1/s1
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n/an/a 60n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50250364
PNG
(CHEMBL4063323)
PDB
MMDB

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n/an/a 60n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc.

Curated by ChEMBL




J Med Chem 60: 8466-8481 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00900
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50250366
PNG
(CHEMBL4075773)
PDB
MMDB

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n/an/a 62n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc.

Curated by ChEMBL




J Med Chem 60: 8466-8481 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00900
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124877
PNG
(US8759365, 18)
Show SMILES CC[C@@H]1C[C@@H](CN1C(=O)N(C)C)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1
Show InChI InChI=1S/C26H29F6N7O/c1-5-21-9-22(15-39(21)24(40)36(2)3)38(23-33-10-17(11-34-23)18-12-35-37(4)14-18)13-16-6-19(25(27,28)29)8-20(7-16)26(30,31)32/h6-8,10-12,14,21-22H,5,9,13,15H2,1-4H3/t21-,22+/m1/s1
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n/an/a 63n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124864
PNG
(US8759365, 6-1)
Show SMILES CC[C@@H]1C[C@@H](CN1C(=O)OCC(C)C)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C28H32F6N6O2/c1-5-23-9-24(15-40(23)26(41)42-16-17(2)3)39(25-35-10-19(11-36-25)20-12-37-38(4)14-20)13-18-6-21(27(29,30)31)8-22(7-18)28(32,33)34/h6-8,10-12,14,17,23-24H,5,9,13,15-16H2,1-4H3/t23-,24+/m1/s1
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n/an/a 69n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124873
PNG
(US8759365, 9-6)
Show SMILES CC[C@@H]1C[C@@H](CN1C(=O)OCC1(CC)COC1)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C30H34F6N6O3/c1-4-24-9-25(15-42(24)27(43)45-18-28(5-2)16-44-17-28)41(26-37-10-20(11-38-26)21-12-39-40(3)14-21)13-19-6-22(29(31,32)33)8-23(7-19)30(34,35)36/h6-8,10-12,14,24-25H,4-5,9,13,15-18H2,1-3H3/t24-,25+/m1/s1
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n/an/a 70n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124870
PNG
(US8759365, 9-3)
Show SMILES CC[C@@H]1C[C@@H](CN1C(=O)OC1CCCC1)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C29H32F6N6O2/c1-3-23-11-24(17-41(23)27(42)43-25-6-4-5-7-25)40(26-36-12-19(13-37-26)20-14-38-39(2)16-20)15-18-8-21(28(30,31)32)10-22(9-18)29(33,34)35/h8-10,12-14,16,23-25H,3-7,11,15,17H2,1-2H3/t23-,24+/m1/s1
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n/an/a 70n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50250363
PNG
(CHEMBL4070653)
PDB
MMDB

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n/an/a 71n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc.

Curated by ChEMBL




J Med Chem 60: 8466-8481 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00900
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124874
PNG
(US8759365, 11)
Show SMILES CC[C@@H]1C[C@@H](CN1C(=O)OC(C)C)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)N1CC[C@H](O)C1
Show InChI InChI=1S/C27H33F6N5O3/c1-4-20-10-21(14-38(20)25(40)41-16(2)3)37(24-34-11-22(12-35-24)36-6-5-23(39)15-36)13-17-7-18(26(28,29)30)9-19(8-17)27(31,32)33/h7-9,11-12,16,20-21,23,39H,4-6,10,13-15H2,1-3H3/t20-,21+,23+/m1/s1
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n/an/a 72n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50250355
PNG
(CHEMBL4081265)
PDB
MMDB

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n/an/a 77n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc.

Curated by ChEMBL




J Med Chem 60: 8466-8481 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00900
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124879
PNG
(US8759365, 32)
Show SMILES CC[C@@H]1C[C@@H](CN1c1nc(ncc1Cl)N1CCC(CC1)C(O)=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C33H34ClF6N9O2/c1-3-25-11-26(18-48(25)28-27(34)15-43-31(45-28)47-6-4-20(5-7-47)29(50)51)49(30-41-12-21(13-42-30)22-14-44-46(2)17-22)16-19-8-23(32(35,36)37)10-24(9-19)33(38,39)40/h8-10,12-15,17,20,25-26H,3-7,11,16,18H2,1-2H3,(H,50,51)/t25-,26+/m1/s1
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n/an/a 77n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124863
PNG
(US8759365, 5-3)
Show SMILES CC[C@@H]1C[C@@H](CN1C(=O)C1CCCCC1)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C30H34F6N6O/c1-3-25-12-26(18-41(25)27(43)20-7-5-4-6-8-20)42(28-37-13-21(14-38-28)22-15-39-40(2)17-22)16-19-9-23(29(31,32)33)11-24(10-19)30(34,35)36/h9-11,13-15,17,20,25-26H,3-8,12,16,18H2,1-2H3/t25-,26+/m1/s1
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n/an/a 92n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WNK1


(Homo sapiens (Human))
BDBM50258581
PNG
(CHEMBL4070177)
PDB
MMDB

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n/an/a 95n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.

Curated by ChEMBL




J Med Chem 60: 7099-7107 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00708
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WNK1


(Homo sapiens (Human))
BDBM50258567
PNG
(CHEMBL4060478)
PDB
MMDB

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n/an/a 106n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.

Curated by ChEMBL




J Med Chem 60: 7099-7107 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00708
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124885
PNG
(US8759365, 23-6)
Show SMILES CC[C@@H]1C[C@@H](CN1c1nc(ncc1Cl)N1CCC(O)CC1)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)N1CCC(O)C1 |r|
Show InChI InChI=1S/C32H37ClF6N8O2/c1-2-22-12-23(17-46(22)28-27(33)15-42-30(43-28)44-6-3-25(48)4-7-44)47(29-40-13-24(14-41-29)45-8-5-26(49)18-45)16-19-9-20(31(34,35)36)11-21(10-19)32(37,38)39/h9-11,13-15,22-23,25-26,48-49H,2-8,12,16-18H2,1H3/t22-,23+,26?/m1/s1
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n/an/a 110n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50381415
PNG
(EVACETRAPIB | LY2484595)
Show SMILES Cc1cc(C)c2N(C[C@H]3CC[C@@H](CC3)C(O)=O)CCC[C@H](N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)c3nnn(C)n3)c2c1 |r,wU:20.21,11.14,wD:8.7,(-5.45,-18.22,;-4.12,-17.45,;-2.78,-18.22,;-1.45,-17.44,;-.11,-18.2,;-1.45,-15.91,;-.01,-15.34,;1.12,-16.38,;2.59,-15.92,;3.91,-16.71,;5.25,-15.96,;5.27,-14.42,;3.95,-13.63,;2.6,-14.38,;6.62,-13.68,;7.94,-14.47,;6.65,-12.14,;.44,-13.86,;-.45,-12.58,;-1.99,-12.47,;-3.03,-13.61,;-4.36,-12.84,;-4.37,-11.31,;-5.7,-10.54,;-5.7,-8.99,;-7.04,-8.22,;-8.37,-8.99,;-8.37,-10.54,;-7.04,-11.31,;-9.7,-11.31,;-11.04,-10.54,;-9.7,-12.85,;-11.05,-12.07,;-7.04,-6.69,;-5.71,-5.91,;-8.38,-5.92,;-7.06,-5.14,;-5.69,-13.62,;-7.1,-12.98,;-8.13,-14.13,;-7.35,-15.46,;-7.98,-16.87,;-5.85,-15.14,;-2.79,-15.14,;-4.12,-15.91,)|
Show InChI InChI=1S/C31H36F6N6O2/c1-18-11-19(2)27-25(12-18)26(5-4-10-42(27)16-20-6-8-22(9-7-20)28(44)45)43(29-38-40-41(3)39-29)17-21-13-23(30(32,33)34)15-24(14-21)31(35,36)37/h11-15,20,22,26H,4-10,16-17H2,1-3H3,(H,44,45)/t20-,22-,26-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc.

Curated by ChEMBL




J Med Chem 60: 8466-8481 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00900
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM124880
PNG
(US8759365, 33-2)
Show SMILES CC[C@@H]1C[C@@H](CN1c1nc(ncc1Cl)N1CCC(CC1)C(O)=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(cn1)N1CCOCC1 |r|
Show InChI InChI=1S/C33H37ClF6N8O3/c1-2-24-14-25(19-47(24)28-27(34)17-43-31(44-28)46-5-3-21(4-6-46)29(49)50)48(30-41-15-26(16-42-30)45-7-9-51-10-8-45)18-20-11-22(32(35,36)37)13-23(12-20)33(38,39)40/h11-13,15-17,21,24-25H,2-10,14,18-19H2,1H3,(H,49,50)/t24-,25+/m1/s1
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n/an/a 130n/an/an/an/a7.437



Novartis AG

US Patent


Assay Description
CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #...


US Patent US8759365 (2014)


BindingDB Entry DOI: 10.7270/Q2NG4P95
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50250365
PNG
(CHEMBL4103344)
PDB
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n/an/a 150n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc.

Curated by ChEMBL




J Med Chem 60: 8466-8481 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00900
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50250355
PNG
(CHEMBL4081265)
PDB
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n/an/a 160n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc.

Curated by ChEMBL




J Med Chem 60: 8466-8481 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00900
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WNK1


(Homo sapiens (Human))
BDBM50258546
PNG
(CHEMBL4087727)
PDB
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n/an/a 162n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.

Curated by ChEMBL




J Med Chem 60: 7099-7107 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00708
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50250364
PNG
(CHEMBL4063323)
PDB
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n/an/a 164n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc.

Curated by ChEMBL




J Med Chem 60: 8466-8481 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00900
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50250370
PNG
(CHEMBL4083767)
PDB
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n/an/a 200n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc.

Curated by ChEMBL




J Med Chem 60: 8466-8481 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00900
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50250357
PNG
(CHEMBL4089133)
PDB
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n/an/a 240n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc.

Curated by ChEMBL




J Med Chem 60: 8466-8481 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00900
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WNK1


(Homo sapiens (Human))
BDBM207990
PNG
((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Show SMILES CNc1nc(cs1)-c1ccc2N(CCc2c1)C(=O)c1ccccc1OCc1ccc(Cl)cc1
Show InChI InChI=1S/C26H22ClN3O2S/c1-28-26-29-22(16-33-26)18-8-11-23-19(14-18)12-13-30(23)25(31)21-4-2-3-5-24(21)32-15-17-6-9-20(27)10-7-17/h2-11,14,16H,12-13,15H2,1H3,(H,28,29)
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n/an/a 420n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.

Curated by ChEMBL




J Med Chem 60: 7099-7107 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00708
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
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