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Compile Data Set for Download or QSAR

Found 4521 hits with Last Name = 'kaplan' and Initial = 'j'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM277933
PNG
(2-(((S)-3,3-difluoro-1-((S)-2- hydroxypropanoyl)pi...)
Show SMILES C[C@H](O)C(=O)N1CC[C@H](Oc2ccc(cc2C#N)-c2ncnc(Nc3ccc(cc3)N3CCN(CC3)C3COC3)n2)C(F)(F)C1 |r|
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Gilead Sciences, Inc.

US Patent




US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM277944
PNG
((S)-2-((3,3-difluoro-1-(4H-1,2,4-triazole-3-carbon...)
Show SMILES FC1(F)CN(CC[C@@H]1Oc1ccc(cc1C#N)-c1ncnc(Nc2ccc(cc2)N2CCN(CC2)C2COC2)n1)C(=O)c1nnc[nH]1 |r|
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US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278268
PNG
(2-(((3R,4S)-3-fluoro-1-(5-methyl-4H-1,2,4-triazole...)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncnc(n2)-c2ccc(O[C@H]3CCN(C[C@H]3F)C(=O)c3nnc(C)[nH]3)c(c2)C#N)cc1C |r|
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US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278275
PNG
(2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)pip...)
Show SMILES C[C@H](O)C(=O)N1CC[C@H](Oc2ccc(cc2C#N)-c2ncnc(Nc3ccc(cc3)N3CCNCC3)n2)[C@H](F)C1 |r|
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Gilead Sciences, Inc.

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US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278276
PNG
(2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)pip...)
Show SMILES C[C@H](O)C(=O)N1CC[C@H](Oc2ccc(cc2C#N)-c2ncnc(Nc3ccc(cc3)N3CCN(C)CC3)n2)[C@H](F)C1 |r|
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US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278278
PNG
(5-(4-((4-((S)-2,4-dimethylpiperazin-1-yl)phenyl)am...)
Show SMILES C[C@H]1CN(C)CCN1c1ccc(Nc2ncnc(n2)-c2ccc(O[C@H]3CCN(C[C@H]3F)C(=O)CO)c(c2)C#N)cc1 |r|
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Gilead Sciences, Inc.

US Patent




US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278279
PNG
(5-(4-((4-((S)-2,4-dimethylpiperazin-1-yl)phenyl)am...)
Show SMILES C[C@H](O)C(=O)N1CC[C@H](Oc2ccc(cc2C#N)-c2ncnc(Nc3ccc(cc3)N3CCN(C)C[C@@H]3C)n2)[C@H](F)C1 |r|
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Gilead Sciences, Inc.

US Patent




US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278007
PNG
(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Show SMILES OC[C@H]1CN(CCO1)c1ccc(Nc2ncnc(n2)-c2ccc(O[C@H]3CCN(C[C@H]3F)C(=O)CO)c(c2)C#N)cc1 |r|
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US Patent




US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278286
PNG
(5-(4-((4-((S)-2,4-dimethylpiperazin-1-yl)-3-methox...)
Show SMILES COc1cc(Nc2ncnc(n2)-c2ccc(O[C@H]3CCN(C[C@H]3F)C(=O)CO)c(c2)C#N)ccc1N1CCN(C)C[C@@H]1C |r|
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US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278293
PNG
(2-(((3R,4S)-1-((S)-2,3-dihydroxypropanoyl)-3-fluor...)
Show SMILES C[C@H]1CN(C)CCN1c1ccc(Nc2ncnc(n2)-c2ccc(O[C@H]3CCN(C[C@H]3F)C(=O)[C@@H](O)CO)c(c2)C#N)cc1 |r|
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US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278038
PNG
(2-(((S)-3,3-difluoro-1-(4H-1,2,4-triazole-3-carbon...)
Show SMILES C[C@H]1CN(CCN1c1ccc(Nc2ncnc(n2)-c2ccc(O[C@H]3CCN(CC3(F)F)C(=O)c3nnc[nH]3)c(c2)C#N)cc1)C1COC1 |r|
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US Patent




US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278039
PNG
(2-(((S)-3,3-difluoro-1-(2-hydroxyacetyl)piperidin-...)
Show SMILES C[C@H]1CN(CCN1C1COC1)c1ccc(Nc2ncnc(n2)-c2ccc(O[C@H]3CCN(CC3(F)F)C(=O)CO)c(c2)C#N)cc1 |r|
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Gilead Sciences, Inc.

US Patent




US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278079
PNG
((S)-2-((1-acetyl-3,3-difluoropiperidin-4-yl)oxy)-5...)
Show SMILES CC(=O)N1CC[C@H](Oc2ccc(cc2C#N)-c2ncnc(Nc3ccc(cc3)C3CCNCC3)n2)C(F)(F)C1 |r|
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Gilead Sciences, Inc.

US Patent




US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278080
PNG
((S)-2-((1-acetyl-3,3-difluoropiperidin-4-yl)oxy)-5...)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncnc(n2)-c2ccc(O[C@H]3CCN(CC3(F)F)C(C)=O)c(c2)C#N)cc1 |r|
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Gilead Sciences, Inc.

US Patent




US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278081
PNG
((S)-2-((3,3-difluoro-1-formylpiperidin-4-yl)oxy)-5...)
Show SMILES Cc1cc(Nc2ncnc(n2)-c2ccc(O[C@H]3CCN(CC3(F)F)C=O)c(c2)C#N)ccc1C1CCNCC1 |r|
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US Patent




US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278082
PNG
((S)-2-((3,3-difluoro-1-formylpiperidin-4-yl)oxy)-5...)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncnc(n2)-c2ccc(O[C@H]3CCN(CC3(F)F)C=O)c(c2)C#N)cc1C |r|
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Gilead Sciences, Inc.

US Patent




US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278083
PNG
(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Show SMILES OCC(=O)N1CC[C@H](Oc2ccc(cc2C#N)-c2ncnc(Nc3ccc(cc3)C3CCN(CC3)C3COC3)n2)[C@H](F)C1 |r|
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Gilead Sciences, Inc.

US Patent




US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278084
PNG
(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Show SMILES OCC(=O)N1CC[C@H](Oc2ccc(cc2C#N)-c2ncnc(Nc3ccc(cc3)N3CCN(CC3)C3CCOCC3)n2)[C@H](F)C1 |r|
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Gilead Sciences, Inc.

US Patent




US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM278103
PNG
(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Show SMILES COc1cc(Nc2ncnc(n2)-c2ccc(O[C@H]3CCN(C[C@H]3F)C(=O)CO)c(c2)C#N)ccc1N1CCC(CC1)N1CCOCC1 |r|
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Gilead Sciences, Inc.

US Patent




US Patent US10040781 (2018)


BindingDB Entry DOI: 10.7270/Q22V2J41
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM35595
PNG
(pyrazolo pyrimidine, 28)
Show SMILES COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CO)cc2)cc1)N1CCOCC1
Show InChI InChI=1S/C30H34N8O5/c1-42-30(41)37-12-10-24(11-13-37)38-28-25(18-31-38)27(36-14-16-43-17-15-36)34-26(35-28)21-4-8-23(9-5-21)33-29(40)32-22-6-2-20(19-39)3-7-22/h2-9,18,24,39H,10-17,19H2,1H3,(H2,32,33,40)
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n/an/a 0.0800n/an/an/an/a7.423



Wyeth Research



Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...


J Med Chem 52: 5013-6 (2009)


Article DOI: 10.1021/jm900851f
BindingDB Entry DOI: 10.7270/Q2SJ1HZD
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50315080
PNG
(4-(3-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6...)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)NCCN(C)C)cc1)N1C2CCC1COC2 |r|
Show InChI InChI=1S/C32H41N9O4/c1-21-18-44-17-16-40(21)30-36-28(37-31(38-30)41-26-12-13-27(41)20-45-19-26)22-4-8-24(9-5-22)34-32(43)35-25-10-6-23(7-11-25)29(42)33-14-15-39(2)3/h4-11,21,26-27H,12-20H2,1-3H3,(H,33,42)(H2,34,35,43)/t21-,26?,27?/m1/s1
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n/an/a 0.100n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2648-53 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.031
BindingDB Entry DOI: 10.7270/Q2DZ08GK
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50168297
PNG
(CHEMBL3805760 | US9765060, Compound 96)
Show SMILES C[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1/C22H18ClN7O/c1-12-15(11-24)19(29-22(25)27-12)26-13(2)20-28-17-10-6-9-16(23)18(17)21(31)30(20)14-7-4-3-5-8-14/h3-10,13H,1-2H3,(H3,25,26,27,29)/t13-/s2
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GILEAD SCIENCES, INC.

US Patent




US Patent US9765060 (2017)


BindingDB Entry DOI: 10.7270/Q2DZ0BDH
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50316254
PNG
(CHEMBL1098245 | methyl 4-(6-(4-(3-(4-(2-hydroxyeth...)
Show SMILES COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CCO)cc2)cc1)N1CCOCC1
Show InChI InChI=1S/C31H36N8O5/c1-43-31(42)38-13-10-25(11-14-38)39-29-26(20-32-39)28(37-15-18-44-19-16-37)35-27(36-29)22-4-8-24(9-5-22)34-30(41)33-23-6-2-21(3-7-23)12-17-40/h2-9,20,25,40H,10-19H2,1H3,(H2,33,34,41)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cells


J Med Chem 52: 8010-24 (2009)


Article DOI: 10.1021/jm9013828
BindingDB Entry DOI: 10.7270/Q28W3DGF
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50303282
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Show SMILES CCn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CC2CCC(C1)O2 |TLB:6:27:34:30.31|
Show InChI InChI=1S/C25H26N8O2/c1-2-33-24-21(13-27-33)23(32-14-19-9-10-20(15-32)35-19)30-22(31-24)16-5-7-17(8-6-16)28-25(34)29-18-4-3-11-26-12-18/h3-8,11-13,19-20H,2,9-10,14-15H2,1H3,(H2,28,29,34)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIA


Bioorg Med Chem Lett 19: 6830-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.096
BindingDB Entry DOI: 10.7270/Q2BV7GPR
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), delta


(Homo sapiens (Human))
BDBM50168293
PNG
(CHEMBL3805430)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1/C21H17ClN8O/c1-11(26-18-13(10-23)17(24)28-21(25)29-18)19-27-15-9-5-8-14(22)16(15)20(31)30(19)12-6-3-2-4-7-12/h2-9,11H,1H3,(H5,24,25,26,28,29)/t11-/s2
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Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition human full length PI3Kdelta catalytic subunit/p85alpha assessed as formation of PIP3 after 30 mins by europium labeled GRP-based TR-FRET a...


J Med Chem 59: 3532-48 (2016)


BindingDB Entry DOI: 10.7270/Q22Z17F0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50303298
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Show SMILES CCn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CO)cc2)cc1)N1CC2CCC(C1)O2 |TLB:6:29:36:32.33|
Show InChI InChI=1S/C27H29N7O3/c1-2-34-26-23(13-28-34)25(33-14-21-11-12-22(15-33)37-21)31-24(32-26)18-5-9-20(10-6-18)30-27(36)29-19-7-3-17(16-35)4-8-19/h3-10,13,21-22,35H,2,11-12,14-16H2,1H3,(H2,29,30,36)
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n/an/a 0.100n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIA


Bioorg Med Chem Lett 19: 6830-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.096
BindingDB Entry DOI: 10.7270/Q2BV7GPR
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50303299
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Show SMILES CCn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CCO)cc2)cc1)N1CC2CCC(C1)O2 |TLB:6:30:37:33.34|
Show InChI InChI=1S/C28H31N7O3/c1-2-35-27-24(15-29-35)26(34-16-22-11-12-23(17-34)38-22)32-25(33-27)19-5-9-21(10-6-19)31-28(37)30-20-7-3-18(4-8-20)13-14-36/h3-10,15,22-23,36H,2,11-14,16-17H2,1H3,(H2,30,31,37)
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n/an/a 0.100n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIA


Bioorg Med Chem Lett 19: 6830-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.096
BindingDB Entry DOI: 10.7270/Q2BV7GPR
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), delta


(Homo sapiens (Human))
BDBM50168290
PNG
(CHEMBL3805572)
Show SMILES C[C@H](Nc1ncnc(N)c1C#C)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1/C22H17ClN6O/c1-3-15-19(24)25-12-26-20(15)27-13(2)21-28-17-11-7-10-16(23)18(17)22(30)29(21)14-8-5-4-6-9-14/h1,4-13H,2H3,(H3,24,25,26,27)/t13-/s2
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n/an/a 0.100n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition human full length PI3Kdelta catalytic subunit/p85alpha assessed as formation of PIP3 after 30 mins by europium labeled GRP-based TR-FRET a...


J Med Chem 59: 3532-48 (2016)


BindingDB Entry DOI: 10.7270/Q22Z17F0
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50300067
PNG
(CHEMBL573157 | methyl 4-(4-(8-oxa-3-azabicyclo[3.2...)
Show SMILES COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CC2CCC(C1)O2
Show InChI InChI=1S/C30H33N9O4/c1-42-30(41)37-13-10-22(11-14-37)39-28-25(16-32-39)27(38-17-23-8-9-24(18-38)43-23)35-26(36-28)19-4-6-20(7-5-19)33-29(40)34-21-3-2-12-31-15-21/h2-7,12,15-16,22-24H,8-11,13-14,17-18H2,1H3,(H2,33,34,40)
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n/an/a 0.110n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Flag-tagged human mTOR by DELFIA method


J Med Chem 52: 7942-5 (2009)


Article DOI: 10.1021/jm901415x
BindingDB Entry DOI: 10.7270/Q2WM1DGH
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50306639
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Show SMILES O=C(Nc1ccncc1)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCC4(CC3)OCCO4)c2n1
Show InChI InChI=1S/C31H34N8O4/c40-30(35-22-9-13-32-14-10-22)34-21-3-1-20(2-4-21)27-36-28(38-18-24-5-6-25(19-38)43-24)26-17-33-39(29(26)37-27)23-7-11-31(12-8-23)41-15-16-42-31/h1-4,9-10,13-14,17,23-25H,5-8,11-12,15-16,18-19H2,(H2,32,34,35,40)
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n/an/a 0.120n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 1440-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.086
BindingDB Entry DOI: 10.7270/Q2S46S2T
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50306624
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-is...)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C(C)C)c2n1
Show InChI InChI=1S/C22H27N7O2/c1-13(2)29-21-18(10-24-29)20(28-11-16-8-9-17(12-28)31-16)26-19(27-21)14-4-6-15(7-5-14)25-22(30)23-3/h4-7,10,13,16-17H,8-9,11-12H2,1-3H3,(H2,23,25,30)
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n/an/a 0.120n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 1440-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.086
BindingDB Entry DOI: 10.7270/Q2S46S2T
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50306640
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Show SMILES O=C(Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCC4(CC3)OCCO4)c2n1)Nc1cccnc1
Show InChI InChI=1S/C31H34N8O4/c40-30(35-22-2-1-13-32-16-22)34-21-5-3-20(4-6-21)27-36-28(38-18-24-7-8-25(19-38)43-24)26-17-33-39(29(26)37-27)23-9-11-31(12-10-23)41-14-15-42-31/h1-6,13,16-17,23-25H,7-12,14-15,18-19H2,(H2,34,35,40)
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n/an/a 0.120n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 1440-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.086
BindingDB Entry DOI: 10.7270/Q2S46S2T
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), delta


(Homo sapiens (Human))
BDBM50168297
PNG
(CHEMBL3805760 | US9765060, Compound 96)
Show SMILES C[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1/C22H18ClN7O/c1-12-15(11-24)19(29-22(25)27-12)26-13(2)20-28-17-10-6-9-16(23)18(17)21(31)30(20)14-7-4-3-5-8-14/h3-10,13H,1-2H3,(H3,25,26,27,29)/t13-/s2
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n/an/a 0.130n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition human full length PI3Kdelta catalytic subunit/p85alpha assessed as formation of PIP3 after 30 mins by europium labeled GRP-based TR-FRET a...


J Med Chem 59: 3532-48 (2016)


BindingDB Entry DOI: 10.7270/Q22Z17F0
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50315071
PNG
(4-(3-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6...)
Show SMILES CN(C)CCNC(=O)c1ccc(NC(=O)Nc2ccc(cc2)-c2nc(nc(n2)N2C3CCC2COC3)C2CCOCC2)cc1
Show InChI InChI=1S/C32H40N8O4/c1-39(2)16-15-33-30(41)23-5-9-25(10-6-23)35-32(42)34-24-7-3-21(4-8-24)28-36-29(22-13-17-43-18-14-22)38-31(37-28)40-26-11-12-27(40)20-44-19-26/h3-10,22,26-27H,11-20H2,1-2H3,(H,33,41)(H2,34,35,42)
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n/an/a 0.140n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2648-53 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.031
BindingDB Entry DOI: 10.7270/Q2DZ08GK
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), delta


(Homo sapiens (Human))
BDBM50168299
PNG
(CHEMBL3805664)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cccc(F)c1 |r|
Show InChI InChI=1/C21H16ClFN8O/c1-10(27-18-13(9-24)17(25)29-21(26)30-18)19-28-15-7-3-6-14(22)16(15)20(32)31(19)12-5-2-4-11(23)8-12/h2-8,10H,1H3,(H5,25,26,27,29,30)/t10-/s2
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n/an/a 0.150n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition human full length PI3Kdelta catalytic subunit/p85alpha assessed as formation of PIP3 after 30 mins by europium labeled GRP-based TR-FRET a...


J Med Chem 59: 3532-48 (2016)


BindingDB Entry DOI: 10.7270/Q22Z17F0
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50300072
PNG
(CHEMBL573202 | methyl 4-(4-(3-oxa-8-azabicyclo[3.2...)
Show SMILES COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1C2CCC1COC2
Show InChI InChI=1S/C30H33N9O4/c1-42-30(41)37-13-10-22(11-14-37)39-28-25(16-32-39)27(38-23-8-9-24(38)18-43-17-23)35-26(36-28)19-4-6-20(7-5-19)33-29(40)34-21-3-2-12-31-15-21/h2-7,12,15-16,22-24H,8-11,13-14,17-18H2,1H3,(H2,33,34,40)
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n/an/a 0.160n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Flag-tagged human mTOR by DELFIA method


J Med Chem 52: 7942-5 (2009)


Article DOI: 10.1021/jm901415x
BindingDB Entry DOI: 10.7270/Q2WM1DGH
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50306638
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCC4(CC3)OCCO4)c2n1
Show InChI InChI=1S/C32H35N7O4/c40-31(34-22-4-2-1-3-5-22)35-23-8-6-21(7-9-23)28-36-29(38-19-25-10-11-26(20-38)43-25)27-18-33-39(30(27)37-28)24-12-14-32(15-13-24)41-16-17-42-32/h1-9,18,24-26H,10-17,19-20H2,(H2,34,35,40)
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n/an/a 0.160n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 1440-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.086
BindingDB Entry DOI: 10.7270/Q2S46S2T
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50300077
PNG
(CHEMBL578645 | ethyl 4-(6-(4-(3-ethylureido)phenyl...)
Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OCC)c2n1
Show InChI InChI=1S/C26H34N8O4/c1-3-27-25(35)29-19-7-5-18(6-8-19)22-30-23(32-13-15-37-16-14-32)21-17-28-34(24(21)31-22)20-9-11-33(12-10-20)26(36)38-4-2/h5-8,17,20H,3-4,9-16H2,1-2H3,(H2,27,29,35)
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n/an/a 0.170n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Flag-tagged human mTOR by DELFIA method


J Med Chem 52: 7942-5 (2009)


Article DOI: 10.1021/jm901415x
BindingDB Entry DOI: 10.7270/Q2WM1DGH
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50315056
PNG
(1-(4-(4,6-di(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-...)
Show SMILES OCc1ccc(NC(=O)Nc2ccc(cc2)-c2nc(nc(n2)N2C3CCC2COC3)N2C3CCC2COC3)cc1
Show InChI InChI=1S/C29H33N7O4/c37-13-18-1-5-20(6-2-18)30-29(38)31-21-7-3-19(4-8-21)26-32-27(35-22-9-10-23(35)15-39-14-22)34-28(33-26)36-24-11-12-25(36)17-40-16-24/h1-8,22-25,37H,9-17H2,(H2,30,31,38)
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n/an/a 0.180n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 2648-53 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.031
BindingDB Entry DOI: 10.7270/Q2DZ08GK
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50306620
PNG
(CHEMBL606423 | isopropyl 4-(4-(8-oxa-3-azabicyclo[...)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCN(CC3)C(=O)OC(C)C)c2n1
Show InChI InChI=1S/C28H36N8O4/c1-17(2)39-28(38)34-12-10-20(11-13-34)36-26-23(14-30-36)25(35-15-21-8-9-22(16-35)40-21)32-24(33-26)18-4-6-19(7-5-18)31-27(37)29-3/h4-7,14,17,20-22H,8-13,15-16H2,1-3H3,(H2,29,31,37)
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n/an/a 0.190n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 1440-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.086
BindingDB Entry DOI: 10.7270/Q2S46S2T
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50300070
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...)
Show SMILES FC(F)(F)Cn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CC2CCC(C1)O2
Show InChI InChI=1S/C25H23F3N8O2/c26-25(27,28)14-36-23-20(11-30-36)22(35-12-18-7-8-19(13-35)38-18)33-21(34-23)15-3-5-16(6-4-15)31-24(37)32-17-2-1-9-29-10-17/h1-6,9-11,18-19H,7-8,12-14H2,(H2,31,32,37)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Flag-tagged human mTOR by DELFIA method


J Med Chem 52: 7942-5 (2009)


Article DOI: 10.1021/jm901415x
BindingDB Entry DOI: 10.7270/Q2WM1DGH
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM35592
PNG
(pyrazolo pyrimidine, 24)
Show SMILES COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CCOCC1
Show InChI InChI=1S/C28H31N9O4/c1-40-28(39)36-11-8-22(9-12-36)37-26-23(18-30-37)25(35-13-15-41-16-14-35)33-24(34-26)19-4-6-20(7-5-19)31-27(38)32-21-3-2-10-29-17-21/h2-7,10,17-18,22H,8-9,11-16H2,1H3,(H2,31,32,38)
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n/an/a 0.200n/an/an/an/a7.423



Wyeth Research



Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...


J Med Chem 52: 5013-6 (2009)


Article DOI: 10.1021/jm900851f
BindingDB Entry DOI: 10.7270/Q2SJ1HZD
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50300074
PNG
(1-(4-(4-morpholino-1-(2,2,2-trifluoroethyl)-1H-pyr...)
Show SMILES FC(F)(F)Cn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CCOCC1
Show InChI InChI=1S/C23H21F3N8O2/c24-23(25,26)14-34-21-18(13-28-34)20(33-8-10-36-11-9-33)31-19(32-21)15-3-5-16(6-4-15)29-22(35)30-17-2-1-7-27-12-17/h1-7,12-13H,8-11,14H2,(H2,29,30,35)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR in HEK293 cells by DELFIA assay


Bioorg Med Chem Lett 20: 640-3 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.050
BindingDB Entry DOI: 10.7270/Q2C829DN
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM35592
PNG
(pyrazolo pyrimidine, 24)
Show SMILES COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CCOCC1
Show InChI InChI=1S/C28H31N9O4/c1-40-28(39)36-11-8-22(9-12-36)37-26-23(18-30-37)25(35-13-15-41-16-14-35)33-24(34-26)19-4-6-20(7-5-19)31-27(38)32-21-3-2-10-29-17-21/h2-7,10,17-18,22H,8-9,11-16H2,1H3,(H2,31,32,38)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Flag-tagged human mTOR by DELFIA method


J Med Chem 52: 7942-5 (2009)


Article DOI: 10.1021/jm901415x
BindingDB Entry DOI: 10.7270/Q2WM1DGH
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50300071
PNG
(CHEMBL577137 | methyl 4-(4-(8-oxa-3-azabicyclo[3.2...)
Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCN(CC3)C(=O)OC)c2n1
Show InChI InChI=1S/C27H34N8O4/c1-3-28-26(36)30-18-6-4-17(5-7-18)23-31-24(34-15-20-8-9-21(16-34)39-20)22-14-29-35(25(22)32-23)19-10-12-33(13-11-19)27(37)38-2/h4-7,14,19-21H,3,8-13,15-16H2,1-2H3,(H2,28,30,36)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Flag-tagged human mTOR by DELFIA method


J Med Chem 52: 7942-5 (2009)


Article DOI: 10.1021/jm901415x
BindingDB Entry DOI: 10.7270/Q2WM1DGH
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50303295
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Show SMILES CCn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CN)cc2)cc1)N1CC2CCC(C1)O2 |TLB:6:29:36:32.33|
Show InChI InChI=1S/C27H30N8O2/c1-2-35-26-23(14-29-35)25(34-15-21-11-12-22(16-34)37-21)32-24(33-26)18-5-9-20(10-6-18)31-27(36)30-19-7-3-17(13-28)4-8-19/h3-10,14,21-22H,2,11-13,15-16,28H2,1H3,(H2,30,31,36)
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n/an/a 0.200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIA


Bioorg Med Chem Lett 19: 6830-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.096
BindingDB Entry DOI: 10.7270/Q2BV7GPR
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50316255
PNG
(CHEMBL1095932 | Isopropyl 4-(6-(4-(3-Methylureido)...)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OC(C)C)c2n1
Show InChI InChI=1S/C26H34N8O4/c1-17(2)38-26(36)33-10-8-20(9-11-33)34-24-21(16-28-34)23(32-12-14-37-15-13-32)30-22(31-24)18-4-6-19(7-5-18)29-25(35)27-3/h4-7,16-17,20H,8-15H2,1-3H3,(H2,27,29,35)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cells


J Med Chem 52: 8010-24 (2009)


Article DOI: 10.1021/jm9013828
BindingDB Entry DOI: 10.7270/Q28W3DGF
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50303280
PNG
(4-(3-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1...)
Show SMILES CCn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)NN2CCCC2)cc1)N1CC2CCC(C1)O2 |TLB:6:35:42:38.39|
Show InChI InChI=1S/C31H35N9O3/c1-2-40-29-26(17-32-40)28(38-18-24-13-14-25(19-38)43-24)35-27(36-29)20-5-9-22(10-6-20)33-31(42)34-23-11-7-21(8-12-23)30(41)37-39-15-3-4-16-39/h5-12,17,24-25H,2-4,13-16,18-19H2,1H3,(H,37,41)(H2,33,34,42)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIA


Bioorg Med Chem Lett 19: 6830-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.096
BindingDB Entry DOI: 10.7270/Q2BV7GPR
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50303281
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Show SMILES CCn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2)cc1)N1CC2CCC(C1)O2 |TLB:6:33:40:36.37|
Show InChI InChI=1S/C30H34N8O3/c1-2-38-29-26(17-31-38)28(37-18-24-11-12-25(19-37)41-24)34-27(35-29)20-3-5-21(6-4-20)32-30(39)33-22-7-9-23(10-8-22)36-13-15-40-16-14-36/h3-10,17,24-25H,2,11-16,18-19H2,1H3,(H2,32,33,39)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIA


Bioorg Med Chem Lett 19: 6830-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.096
BindingDB Entry DOI: 10.7270/Q2BV7GPR
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50303292
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...)
Show SMILES FC(F)(F)Cn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCNCC2)cc1)N1CC2CCC(C1)O2 |TLB:9:36:43:39.40|
Show InChI InChI=1S/C30H32F3N9O2/c31-30(32,33)18-42-28-25(15-35-42)27(41-16-23-9-10-24(17-41)44-23)38-26(39-28)19-1-3-20(4-2-19)36-29(43)37-21-5-7-22(8-6-21)40-13-11-34-12-14-40/h1-8,15,23-24,34H,9-14,16-18H2,(H2,36,37,43)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIA


Bioorg Med Chem Lett 19: 6830-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.096
BindingDB Entry DOI: 10.7270/Q2BV7GPR
More data for this
Ligand-Target Pair
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