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Compile Data Set for Download or QSAR

Found 59 hits with Last Name = 'kiyama' and Initial = 'r'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031962
PNG
(3-(5,7-Dimethyl-2-propyl-imidazo[4,5-b]pyridin-3-y...)
Show SMILES CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(cc3ccccc3c(=O)c2c1)-c1nnn[nH]1
Show InChI InChI=1S/C28H25N7O/c1-4-7-24-30-25-16(2)12-17(3)29-28(25)35(24)15-18-10-11-21-22(13-18)26(36)20-9-6-5-8-19(20)14-23(21)27-31-33-34-32-27/h5-6,8-14H,4,7,15H2,1-3H3,(H,31,32,33,34)
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0.290n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031954
PNG
(3-(2-Cyclopropyl-5,7-dimethyl-imidazo[4,5-b]pyridi...)
Show SMILES Cc1cc(C)c2nc(C3CC3)n(Cc3ccc4c(cc5ccccc5c(=O)c4c3)-c3nnn[nH]3)c2n1
Show InChI InChI=1S/C28H23N7O/c1-15-11-16(2)29-28-24(15)30-27(18-8-9-18)35(28)14-17-7-10-21-22(12-17)25(36)20-6-4-3-5-19(20)13-23(21)26-31-33-34-32-26/h3-7,10-13,18H,8-9,14H2,1-2H3,(H,31,32,33,34)
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0.450n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031953
PNG
(3-(2-Ethyl-6-methoxy-[1,5]naphthyridin-4-yloxymeth...)
Show SMILES CCc1cc(OCc2ccc3c(cc4ccccc4c(=O)c3c2)-c2nnn[nH]2)c2nc(OC)ccc2n1
Show InChI InChI=1S/C28H22N6O3/c1-3-18-14-24(26-23(29-18)10-11-25(30-26)36-2)37-15-16-8-9-20-21(12-16)27(35)19-7-5-4-6-17(19)13-22(20)28-31-33-34-32-28/h4-14H,3,15H2,1-2H3,(H,31,32,33,34)
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0.480n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031957
PNG
(5,7-Dimethyl-2-propyl-3-[11-(1H-tetrazol-5-yl)-5H-...)
Show SMILES CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(Cc3ccccc3C=C2c2nnn[nH]2)c1 |c:30|
Show InChI InChI=1S/C28H27N7/c1-4-7-25-30-26-17(2)12-18(3)29-28(26)35(25)16-19-10-11-23-22(13-19)14-20-8-5-6-9-21(20)15-24(23)27-31-33-34-32-27/h5-6,8-13,15H,4,7,14,16H2,1-3H3,(H,31,32,33,34)
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0.490n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031960
PNG
(3-(2-Ethyl-quinolin-4-yloxymethyl)-11-(1H-tetrazol...)
Show SMILES CCc1cc(OCc2ccc3c(cc4ccccc4c(=O)c3c2)-c2nnn[nH]2)c2ccccc2n1
Show InChI InChI=1S/C28H21N5O2/c1-2-19-15-26(22-9-5-6-10-25(22)29-19)35-16-17-11-12-21-23(13-17)27(34)20-8-4-3-7-18(20)14-24(21)28-30-32-33-31-28/h3-15H,2,16H2,1H3,(H,30,31,32,33)
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0.650n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031961
PNG
(3-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-yl...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(cc3ccccc3c(=O)c2c1)-c1nnn[nH]1
Show InChI InChI=1S/C27H23N7O/c1-4-23-29-24-15(2)11-16(3)28-27(24)34(23)14-17-9-10-20-21(12-17)25(35)19-8-6-5-7-18(19)13-22(20)26-30-32-33-31-26/h5-13H,4,14H2,1-3H3,(H,30,31,32,33)
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0.660n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031955
PNG
(5,7-Dimethyl-2-propyl-3-[11-(1H-tetrazol-5-yl)-dib...)
Show SMILES CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(Oc3ccccc3C=C2c2nnn[nH]2)c1 |c:30|
Show InChI InChI=1S/C27H25N7O/c1-4-7-24-29-25-16(2)12-17(3)28-27(25)34(24)15-18-10-11-20-21(26-30-32-33-31-26)14-19-8-5-6-9-22(19)35-23(20)13-18/h5-6,8-14H,4,7,15H2,1-3H3,(H,30,31,32,33)
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0.700n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031964
PNG
(3-[(5-Ethyl-pyrazolo[1,5-a]pyrimidin-7-ylamino)-me...)
Show SMILES CCc1cc(NCc2ccc3c(cc4ccccc4c(=O)c3c2)-c2nnn[nH]2)n2nccc2n1
Show InChI InChI=1S/C25H20N8O/c1-2-17-13-23(33-22(28-17)9-10-27-33)26-14-15-7-8-19-20(11-15)24(34)18-6-4-3-5-16(18)12-21(19)25-29-31-32-30-25/h3-13,26H,2,14H2,1H3,(H,29,30,31,32)
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1.10n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031956
PNG
(3-(2-Ethyl-5,6,7,8-tetrahydro-quinolin-4-yloxymeth...)
Show SMILES CCc1cc(OCc2ccc3c(cc4ccccc4c(=O)c3c2)-c2nnn[nH]2)c2CCCCc2n1
Show InChI InChI=1S/C28H25N5O2/c1-2-19-15-26(22-9-5-6-10-25(22)29-19)35-16-17-11-12-21-23(13-17)27(34)20-8-4-3-7-18(20)14-24(21)28-30-32-33-31-28/h3-4,7-8,11-15H,2,5-6,9-10,16H2,1H3,(H,30,31,32,33)
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1.30n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031959
PNG
(2-Butyl-5-chloro-3-[5-oxo-11-(1H-tetrazol-5-yl)-5H...)
Show SMILES CCCCc1nc(Cl)c(C(O)=O)n1Cc1ccc2c(cc3ccccc3c(=O)c2c1)-c1nnn[nH]1
Show InChI InChI=1S/C25H21ClN6O3/c1-2-3-8-20-27-23(26)21(25(34)35)32(20)13-14-9-10-17-18(11-14)22(33)16-7-5-4-6-15(16)12-19(17)24-28-30-31-29-24/h4-7,9-12H,2-3,8,13H2,1H3,(H,34,35)(H,28,29,30,31)
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2.10n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031966
PNG
(2-Ethoxy-3-[5-oxo-11-(1H-tetrazol-5-yl)-5H-dibenzo...)
Show SMILES CCOc1nc2cccc(C(O)=O)c2n1Cc1ccc2c(cc3ccccc3c(=O)c2c1)-c1nnn[nH]1
Show InChI InChI=1S/C27H20N6O4/c1-2-37-27-28-22-9-5-8-19(26(35)36)23(22)33(27)14-15-10-11-18-20(12-15)24(34)17-7-4-3-6-16(17)13-21(18)25-29-31-32-30-25/h3-13H,2,14H2,1H3,(H,35,36)(H,29,30,31,32)
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2.70n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031965
PNG
(2-Ethyl-4-[5-oxo-11-(1H-tetrazol-5-yl)-5H-dibenzo[...)
Show SMILES CCc1cc(OCc2ccc3c(cc4ccccc4c(=O)c3c2)-c2nnn[nH]2)c2cc(ccc2n1)C(O)=O
Show InChI InChI=1S/C29H21N5O4/c1-2-19-14-26(24-13-18(29(36)37)8-10-25(24)30-19)38-15-16-7-9-21-22(11-16)27(35)20-6-4-3-5-17(20)12-23(21)28-31-33-34-32-28/h3-14H,2,15H2,1H3,(H,36,37)(H,31,32,33,34)
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2.70n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031950
PNG
(2,6-Dimethyl-4-{[5-oxo-11-(1H-tetrazol-5-yl)-5H-di...)
Show SMILES CCOC(=O)c1c(C)nc(C)cc1NCc1ccc2c(cc3ccccc3c(=O)c2c1)-c1nnn[nH]1
Show InChI InChI=1S/C27H24N6O3/c1-4-36-27(35)24-16(3)29-15(2)11-23(24)28-14-17-9-10-20-21(12-17)25(34)19-8-6-5-7-18(19)13-22(20)26-30-32-33-31-26/h5-13H,4,14H2,1-3H3,(H,28,29)(H,30,31,32,33)
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2.90n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031951
PNG
(2-Ethoxy-3-[11-(1H-tetrazol-5-yl)-dibenzo[b,f]oxep...)
Show SMILES CCOc1nc2cccc(C(O)=O)c2n1Cc1ccc2c(Oc3ccccc3C=C2c2nnn[nH]2)c1 |c:31|
Show InChI InChI=1S/C26H20N6O4/c1-2-35-26-27-20-8-5-7-18(25(33)34)23(20)32(26)14-15-10-11-17-19(24-28-30-31-29-24)13-16-6-3-4-9-21(16)36-22(17)12-15/h3-13H,2,14H2,1H3,(H,33,34)(H,28,29,30,31)
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3.90n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031963
PNG
(2,6-Dimethyl-4-[5-oxo-11-(1H-tetrazol-5-yl)-5H-dib...)
Show SMILES CCOC(=O)c1c(C)nc(C)cc1OCc1ccc2c(cc3ccccc3c(=O)c2c1)-c1nnn[nH]1
Show InChI InChI=1S/C27H23N5O4/c1-4-35-27(34)24-16(3)28-15(2)11-23(24)36-14-17-9-10-20-21(12-17)25(33)19-8-6-5-7-18(19)13-22(20)26-29-31-32-30-26/h5-13H,4,14H2,1-3H3,(H,29,30,31,32)
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4.30n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031949
PNG
(3-(2-Methyl-5,6,7,8-tetrahydro-quinolin-4-yloxymet...)
Show SMILES Cc1cc(OCc2ccc3c(cc4ccccc4c(=O)c3c2)-c2nnn[nH]2)c2CCCCc2n1
Show InChI InChI=1S/C27H23N5O2/c1-16-12-25(21-8-4-5-9-24(21)28-16)34-15-17-10-11-20-22(13-17)26(33)19-7-3-2-6-18(19)14-23(20)27-29-31-32-30-27/h2-3,6-7,10-14H,4-5,8-9,15H2,1H3,(H,29,30,31,32)
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4.30n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031952
PNG
((S)-3-Methyl-2-{[5-oxo-11-(1H-tetrazol-5-yl)-5H-di...)
Show SMILES CCCCC(=O)N(Cc1ccc2c(cc3ccccc3c(=O)c2c1)-c1nnn[nH]1)[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C27H29N5O4/c1-4-5-10-23(33)32(24(16(2)3)27(35)36)15-17-11-12-20-21(13-17)25(34)19-9-7-6-8-18(19)14-22(20)26-28-30-31-29-26/h6-9,11-14,16,24H,4-5,10,15H2,1-3H3,(H,35,36)(H,28,29,30,31)/t24-/m0/s1
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8.70n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031958
PNG
((S)-3-Methyl-2-{pentanoyl-[11-(1H-tetrazol-5-yl)-d...)
Show SMILES CCCCC(=O)N(Cc1ccc2c(Oc3ccccc3C=C2c2nnn[nH]2)c1)[C@@H](C(C)C)C(O)=O |c:21|
Show InChI InChI=1S/C26H29N5O4/c1-4-5-10-23(32)31(24(16(2)3)26(33)34)15-17-11-12-19-20(25-27-29-30-28-25)14-18-8-6-7-9-21(18)35-22(19)13-17/h6-9,11-14,16,24H,4-5,10,15H2,1-3H3,(H,33,34)(H,27,28,29,30)/t24-/m0/s1
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9.60n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031948
PNG
(2-Butyl-5-chloro-3-[5-oxo-11-(1H-tetrazol-5-yl)-5H...)
Show SMILES CCCCc1nc(Cl)c(C=O)n1Cc1ccc2c(cc3ccccc3c(=O)c2c1)-c1nnn[nH]1
Show InChI InChI=1S/C25H21ClN6O2/c1-2-3-8-22-27-24(26)21(14-33)32(22)13-15-9-10-18-19(11-15)23(34)17-7-5-4-6-16(17)12-20(18)25-28-30-31-29-25/h4-7,9-12,14H,2-3,8,13H2,1H3,(H,28,29,30,31)
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12n/an/an/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1


J Med Chem 38: 2728-41 (1995)


BindingDB Entry DOI: 10.7270/Q23B5Z5Q
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077162
PNG
((R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethyny...)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C26H22N2O5S/c1-33-21-12-8-18(9-13-21)6-7-19-10-14-22(15-11-19)34(31,32)28-25(26(29)30)16-20-17-27-24-5-3-2-4-23(20)24/h2-5,8-15,17,25,27-28H,16H2,1H3,(H,29,30)/t25-/m1/s1
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n/an/a 0.650n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077157
PNG
((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Show SMILES CCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C25H22N2O4S2/c1-2-17-7-9-18(10-8-17)11-12-20-13-14-24(32-20)33(30,31)27-23(25(28)29)15-19-16-26-22-6-4-3-5-21(19)22/h3-10,13-14,16,23,26-27H,2,15H2,1H3,(H,28,29)/t23-/m1/s1
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n/an/a 1.5n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50063129
PNG
((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Show SMILES Cc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C24H20N2O4S2/c1-16-6-8-17(9-7-16)10-11-19-12-13-23(31-19)32(29,30)26-22(24(27)28)14-18-15-25-21-5-3-2-4-20(18)21/h2-9,12-13,15,22,25-26H,14H2,1H3,(H,27,28)/t22-/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077161
PNG
((R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulf...)
Show SMILES CCCCOc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C27H26N2O5S2/c1-2-3-16-34-21-11-8-19(9-12-21)10-13-22-14-15-26(35-22)36(32,33)29-25(27(30)31)17-20-18-28-24-7-5-4-6-23(20)24/h4-9,11-12,14-15,18,25,28-29H,2-3,16-17H2,1H3,(H,30,31)/t25-/m1/s1
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n/an/a 3.90n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077151
PNG
((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Show SMILES CCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C19H21NO4S2/c1-4-14-5-7-15(8-6-14)9-10-16-11-12-17(25-16)26(23,24)20-18(13(2)3)19(21)22/h5-8,11-13,18,20H,4H2,1-3H3,(H,21,22)/t18-/m1/s1
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n/an/a 4.40n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077152
PNG
((R)-3-Phenyl-2-([1,1';4',1'']terphenyl-4-sulfonyla...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H23NO4S/c29-27(30)26(19-20-7-3-1-4-8-20)28-33(31,32)25-17-15-24(16-18-25)23-13-11-22(12-14-23)21-9-5-2-6-10-21/h1-18,26,28H,19H2,(H,29,30)/t26-/m1/s1
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n/an/a 4.40n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077155
PNG
((R)-2-[5-(4-Butyl-phenylethynyl)-thiophene-2-sulfo...)
Show SMILES CCCCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C27H26N2O4S2/c1-2-3-6-19-9-11-20(12-10-19)13-14-22-15-16-26(34-22)35(32,33)29-25(27(30)31)17-21-18-28-24-8-5-4-7-23(21)24/h4-5,7-12,15-16,18,25,28-29H,2-3,6,17H2,1H3,(H,30,31)/t25-/m1/s1
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n/an/a 4.40n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077163
PNG
((R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulf...)
Show SMILES CCCCOc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C21H25NO5S2/c1-4-5-14-27-17-9-6-16(7-10-17)8-11-18-12-13-19(28-18)29(25,26)22-20(15(2)3)21(23)24/h6-7,9-10,12-13,15,20,22H,4-5,14H2,1-3H3,(H,23,24)/t20-/m1/s1
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n/an/a 4.70n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077151
PNG
((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Show SMILES CCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C19H21NO4S2/c1-4-14-5-7-15(8-6-14)9-10-16-11-12-17(25-16)26(23,24)20-18(13(2)3)19(21)22/h5-8,11-13,18,20H,4H2,1-3H3,(H,21,22)/t18-/m1/s1
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n/an/a 4.80n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077158
PNG
((R)-2-[5-(4-Butyl-phenylethynyl)-thiophene-2-sulfo...)
Show SMILES CCCCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C21H25NO4S2/c1-4-5-6-16-7-9-17(10-8-16)11-12-18-13-14-19(27-18)28(25,26)22-20(15(2)3)21(23)24/h7-10,13-15,20,22H,4-6H2,1-3H3,(H,23,24)/t20-/m1/s1
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n/an/a 5.40n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50063164
PNG
((R)-3-Methyl-2-(5-p-tolylethynyl-thiophene-2-sulfo...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(s1)C#Cc1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C18H19NO4S2/c1-12(2)17(18(20)21)19-25(22,23)16-11-10-15(24-16)9-8-14-6-4-13(3)5-7-14/h4-7,10-12,17,19H,1-3H3,(H,20,21)/t17-/m1/s1
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n/an/a 5.90n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077157
PNG
((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Show SMILES CCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C25H22N2O4S2/c1-2-17-7-9-18(10-8-17)11-12-20-13-14-24(32-20)33(30,31)27-23(25(28)29)15-19-16-26-22-6-4-3-5-21(19)22/h3-10,13-14,16,23,26-27H,2,15H2,1H3,(H,28,29)/t23-/m1/s1
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n/an/a 7.30n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077162
PNG
((R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethyny...)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C26H22N2O5S/c1-33-21-12-8-18(9-13-21)6-7-19-10-14-22(15-11-19)34(31,32)28-25(26(29)30)16-20-17-27-24-5-3-2-4-23(20)24/h2-5,8-15,17,25,27-28H,16H2,1H3,(H,29,30)/t25-/m1/s1
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n/an/a 8.20n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50063129
PNG
((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Show SMILES Cc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C24H20N2O4S2/c1-16-6-8-17(9-7-16)10-11-19-12-13-23(31-19)32(29,30)26-22(24(27)28)14-18-15-25-21-5-3-2-4-20(18)21/h2-9,12-13,15,22,25-26H,14H2,1H3,(H,27,28)/t22-/m1/s1
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n/an/a 9.60n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077164
PNG
((R)-3-(1H-Indol-3-yl)-2-[5-(4-phenoxy-phenylethyny...)
Show SMILES OC(=O)[C@@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1ccc(s1)C#Cc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H22N2O5S2/c32-29(33)27(18-21-19-30-26-9-5-4-8-25(21)26)31-38(34,35)28-17-16-24(37-28)15-12-20-10-13-23(14-11-20)36-22-6-2-1-3-7-22/h1-11,13-14,16-17,19,27,30-31H,18H2,(H,32,33)/t27-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077152
PNG
((R)-3-Phenyl-2-([1,1';4',1'']terphenyl-4-sulfonyla...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H23NO4S/c29-27(30)26(19-20-7-3-1-4-8-20)28-33(31,32)25-17-15-24(16-18-25)23-13-11-22(12-14-23)21-9-5-2-6-10-21/h1-18,26,28H,19H2,(H,29,30)/t26-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077149
PNG
((R)-3-Methyl-2-[5-(4-phenoxy-phenylethynyl)-thioph...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(s1)C#Cc1ccc(Oc2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C23H21NO5S2/c1-16(2)22(23(25)26)24-31(27,28)21-15-14-20(30-21)13-10-17-8-11-19(12-9-17)29-18-6-4-3-5-7-18/h3-9,11-12,14-16,22,24H,1-2H3,(H,25,26)/t22-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077153
PNG
((R)-3-Phenyl-2-(4-phenylethynyl-benzenesulfonylami...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)C#Cc1ccccc1
Show InChI InChI=1S/C23H19NO4S/c25-23(26)22(17-20-9-5-2-6-10-20)24-29(27,28)21-15-13-19(14-16-21)12-11-18-7-3-1-4-8-18/h1-10,13-16,22,24H,17H2,(H,25,26)/t22-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50063164
PNG
((R)-3-Methyl-2-(5-p-tolylethynyl-thiophene-2-sulfo...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(s1)C#Cc1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C18H19NO4S2/c1-12(2)17(18(20)21)19-25(22,23)16-11-10-15(24-16)9-8-14-6-4-13(3)5-7-14/h4-7,10-12,17,19H,1-3H3,(H,20,21)/t17-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077150
PNG
((R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethyny...)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1[N+]([O-])=O)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C26H21N3O7S/c1-36-20-11-7-17(8-12-20)6-9-18-10-13-21(15-25(18)29(32)33)37(34,35)28-24(26(30)31)14-19-16-27-23-5-3-2-4-22(19)23/h2-5,7-8,10-13,15-16,24,27-28H,14H2,1H3,(H,30,31)/t24-/m1/s1
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n/an/a 33n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50063133
PNG
((R)-3-Methyl-2-[4-(2-phenyl-2H-tetrazol-5-yl)-benz...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1nnn(n1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C18H19N5O4S/c1-12(2)16(18(24)25)21-28(26,27)15-10-8-13(9-11-15)17-19-22-23(20-17)14-6-4-3-5-7-14/h3-12,16,21H,1-2H3,(H,24,25)/t16-/m1/s1
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n/an/a 72n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077159
PNG
((R)-3-(1H-Indol-3-yl)-2-(5-o-tolylethynyl-thiophen...)
Show SMILES Cc1ccccc1C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C24H20N2O4S2/c1-16-6-2-3-7-17(16)10-11-19-12-13-23(31-19)32(29,30)26-22(24(27)28)14-18-15-25-21-9-5-4-8-20(18)21/h2-9,12-13,15,22,25-26H,14H2,1H3,(H,27,28)/t22-/m1/s1
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n/an/a 81n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077158
PNG
((R)-2-[5-(4-Butyl-phenylethynyl)-thiophene-2-sulfo...)
Show SMILES CCCCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C21H25NO4S2/c1-4-5-6-16-7-9-17(10-8-16)11-12-18-13-14-19(27-18)28(25,26)22-20(15(2)3)21(23)24/h7-10,13-15,20,22H,4-6H2,1-3H3,(H,23,24)/t20-/m1/s1
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n/an/a 210n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077163
PNG
((R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulf...)
Show SMILES CCCCOc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C21H25NO5S2/c1-4-5-14-27-17-9-6-16(7-10-17)8-11-18-12-13-19(28-18)29(25,26)22-20(15(2)3)21(23)24/h6-7,9-10,12-13,15,20,22H,4-5,14H2,1-3H3,(H,23,24)/t20-/m1/s1
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n/an/a 210n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077149
PNG
((R)-3-Methyl-2-[5-(4-phenoxy-phenylethynyl)-thioph...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(s1)C#Cc1ccc(Oc2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C23H21NO5S2/c1-16(2)22(23(25)26)24-31(27,28)21-15-14-20(30-21)13-10-17-8-11-19(12-9-17)29-18-6-4-3-5-7-18/h3-9,11-12,14-16,22,24H,1-2H3,(H,25,26)/t22-/m1/s1
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n/an/a 260n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077153
PNG
((R)-3-Phenyl-2-(4-phenylethynyl-benzenesulfonylami...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)C#Cc1ccccc1
Show InChI InChI=1S/C23H19NO4S/c25-23(26)22(17-20-9-5-2-6-10-20)24-29(27,28)21-15-13-19(14-16-21)12-11-18-7-3-1-4-8-18/h1-10,13-16,22,24H,17H2,(H,25,26)/t22-/m1/s1
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n/an/a 340n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50063157
PNG
((R)-3-(1H-Indol-3-yl)-2-(naphthalene-2-sulfonylami...)
Show SMILES OC(=O)[C@@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C21H18N2O4S/c24-21(25)20(12-16-13-22-19-8-4-3-7-18(16)19)23-28(26,27)17-10-9-14-5-1-2-6-15(14)11-17/h1-11,13,20,22-23H,12H2,(H,24,25)/t20-/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077160
PNG
((R)-3-Methyl-2-{methyl-[4-(2-phenyl-2H-tetrazol-5-...)
Show SMILES CC(C)[C@@H](N(C)S(=O)(=O)c1ccc(cc1)-c1nnn(n1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C19H21N5O4S/c1-13(2)17(19(25)26)23(3)29(27,28)16-11-9-14(10-12-16)18-20-22-24(21-18)15-7-5-4-6-8-15/h4-13,17H,1-3H3,(H,25,26)/t17-/m1/s1
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n/an/a 870n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077159
PNG
((R)-3-(1H-Indol-3-yl)-2-(5-o-tolylethynyl-thiophen...)
Show SMILES Cc1ccccc1C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C24H20N2O4S2/c1-16-6-2-3-7-17(16)10-11-19-12-13-23(31-19)32(29,30)26-22(24(27)28)14-18-15-25-21-9-5-4-8-20(18)21/h2-9,12-13,15,22,25-26H,14H2,1H3,(H,27,28)/t22-/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077150
PNG
((R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethyny...)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1[N+]([O-])=O)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C26H21N3O7S/c1-36-20-11-7-17(8-12-20)6-9-18-10-13-21(15-25(18)29(32)33)37(34,35)28-24(26(30)31)14-19-16-27-23-5-3-2-4-22(19)23/h2-5,7-8,10-13,15-16,24,27-28H,14H2,1H3,(H,30,31)/t24-/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077161
PNG
((R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulf...)
Show SMILES CCCCOc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C27H26N2O5S2/c1-2-3-16-34-21-11-8-19(9-12-21)10-13-22-14-15-26(35-22)36(32,33)29-25(27(30)31)17-20-18-28-24-7-5-4-6-23(20)24/h4-9,11-12,14-15,18,25,28-29H,2-3,16-17H2,1H3,(H,30,31)/t25-/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
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