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Compile Data Set for Download or QSAR

Found 675 hits with Last Name = 'kostenis' and Initial = 'e'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50161748
PNG
(CHEMBL194085 | [3-((R)-4-Fluoro-benzenesulfonylami...)
Show SMILES OC(=O)Cn1c2CC[C@H](Cc2c2ccccc12)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN2O4S/c21-13-5-8-15(9-6-13)28(26,27)22-14-7-10-19-17(11-14)16-3-1-2-4-18(16)23(19)12-20(24)25/h1-6,8-9,14,22H,7,10-12H2,(H,24,25)/t14-/m1/s1
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0.510n/an/an/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of [3H]PGD-2 binding to human chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50161745
PNG
(CHEMBL179036 | {3-[((R)-4-Fluoro-benzenesulfonyl)-...)
Show SMILES CN([C@@H]1CCc2c(C1)c1ccccc1n2CC(O)=O)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H21FN2O4S/c1-23(29(27,28)16-9-6-14(22)7-10-16)15-8-11-20-18(12-15)17-4-2-3-5-19(17)24(20)13-21(25)26/h2-7,9-10,15H,8,11-13H2,1H3,(H,25,26)/t15-/m1/s1
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0.600n/an/an/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of [3H]PGD-2 binding to human chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50161747
PNG
(3-{(R)-3-[(4-Fluoro-benzenesulfonyl)-methyl-amino]...)
Show SMILES CN([C@@H]1CCc2c(C1)c1ccccc1n2CCC(O)=O)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H23FN2O4S/c1-24(30(28,29)17-9-6-15(23)7-10-17)16-8-11-21-19(14-16)18-4-2-3-5-20(18)25(21)13-12-22(26)27/h2-7,9-10,16H,8,11-14H2,1H3,(H,26,27)/t16-/m1/s1
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1.90n/an/an/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of [3H]PGD-2 binding to human chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50161746
PNG
((R)-3-(3-(4-fluorophenylsulfonamido)-1,2,3,4-tetra...)
Show SMILES OC(=O)CCn1c2CC[C@H](Cc2c2ccccc12)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1
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4.30n/an/an/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of [3H]PGD-2 binding to human chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50161746
PNG
((R)-3-(3-(4-fluorophenylsulfonamido)-1,2,3,4-tetra...)
Show SMILES OC(=O)CCn1c2CC[C@H](Cc2c2ccccc12)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1
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4.5n/an/an/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of [3H]-SQ-29,548 binding to human Thromboxane A2 receptor


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50161748
PNG
(CHEMBL194085 | [3-((R)-4-Fluoro-benzenesulfonylami...)
Show SMILES OC(=O)Cn1c2CC[C@H](Cc2c2ccccc12)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN2O4S/c21-13-5-8-15(9-6-13)28(26,27)22-14-7-10-19-17(11-14)16-3-1-2-4-18(16)23(19)12-20(24)25/h1-6,8-9,14,22H,7,10-12H2,(H,24,25)/t14-/m1/s1
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540n/an/an/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of [3H]-SQ-29,548 binding to human Thromboxane A2 receptor


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50161745
PNG
(CHEMBL179036 | {3-[((R)-4-Fluoro-benzenesulfonyl)-...)
Show SMILES CN([C@@H]1CCc2c(C1)c1ccccc1n2CC(O)=O)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H21FN2O4S/c1-23(29(27,28)16-9-6-14(22)7-10-16)15-8-11-20-18(12-15)17-4-2-3-5-19(17)24(20)13-21(25)26/h2-7,9-10,15H,8,11-13H2,1H3,(H,25,26)/t15-/m1/s1
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1.20E+3n/an/an/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PGD-2 binding to human Prostaglandin D2 receptor


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
Uracil nucleotide/cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50004952
PNG
(3-(2-Carboxy-ethyl)-4,6-dichloro-1H-indole-2-carbo...)
Show SMILES OC(=O)CCc1c([nH]c2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C12H9Cl2NO4/c13-5-3-7(14)10-6(1-2-9(16)17)11(12(18)19)15-8(10)4-5/h3-4,15H,1-2H2,(H,16,17)(H,18,19)
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1.21E+3n/an/an/an/an/an/an/an/a



PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn , Bonn, Germany.

Curated by ChEMBL


Assay Description
Displacement of [3H]PSB-12150 from human GPR17 expressed in CHO-K1 cell membranes after 60 mins by homologous competition binding assay in presence o...


ACS Med Chem Lett 5: 326-30 (2014)


Article DOI: 10.1021/ml400399f
BindingDB Entry DOI: 10.7270/Q2445P0D
More data for this
Ligand-Target Pair
Uracil nucleotide/cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50010475
PNG
(GAVESTINEL | GV-150526X)
Show SMILES OC(=O)c1[nH]c2cc(Cl)cc(Cl)c2c1\C=C\C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H12Cl2N2O3/c19-10-8-13(20)16-12(17(18(24)25)22-14(16)9-10)6-7-15(23)21-11-4-2-1-3-5-11/h1-9,22H,(H,21,23)(H,24,25)/b7-6+
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1.63E+3n/an/an/an/an/an/an/an/a



PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn , Bonn, Germany.

Curated by ChEMBL


Assay Description
Displacement of [3H]PSB-12150 from human GPR17 expressed in CHO-K1 cell membranes after 60 mins by heterologous competition binding assay


ACS Med Chem Lett 5: 326-30 (2014)


Article DOI: 10.1021/ml400399f
BindingDB Entry DOI: 10.7270/Q2445P0D
More data for this
Ligand-Target Pair
Uracil nucleotide/cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50004952
PNG
(3-(2-Carboxy-ethyl)-4,6-dichloro-1H-indole-2-carbo...)
Show SMILES OC(=O)CCc1c([nH]c2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C12H9Cl2NO4/c13-5-3-7(14)10-6(1-2-9(16)17)11(12(18)19)15-8(10)4-5/h3-4,15H,1-2H2,(H,16,17)(H,18,19)
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2.32E+3n/an/an/an/an/an/an/an/a



PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn , Bonn, Germany.

Curated by ChEMBL


Assay Description
Displacement of [3H]PSB-12150 from human GPR17 expressed in CHO-K1 cell membranes after 60 mins by competition binding assay


ACS Med Chem Lett 5: 326-30 (2014)


Article DOI: 10.1021/ml400399f
BindingDB Entry DOI: 10.7270/Q2445P0D
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50161747
PNG
(3-{(R)-3-[(4-Fluoro-benzenesulfonyl)-methyl-amino]...)
Show SMILES CN([C@@H]1CCc2c(C1)c1ccccc1n2CCC(O)=O)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H23FN2O4S/c1-24(30(28,29)17-9-6-15(23)7-10-17)16-8-11-21-19(14-16)18-4-2-3-5-20(18)25(21)13-12-22(26)27/h2-7,9-10,16H,8,11-14H2,1H3,(H,26,27)/t16-/m1/s1
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3.00E+3n/an/an/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of [3H]-SQ-29,548 binding to human Thromboxane A2 receptor


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
Uracil nucleotide/cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50023198
PNG
(8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...)
Show SMILES O=C(Nc1cccc2c1oc(cc2=O)-c1nnn[nH]1)c1ccc(OCCCCc2ccccc2)cc1
Show InChI InChI=1S/C27H23N5O4/c33-23-17-24(26-29-31-32-30-26)36-25-21(23)10-6-11-22(25)28-27(34)19-12-14-20(15-13-19)35-16-5-4-9-18-7-2-1-3-8-18/h1-3,6-8,10-15,17H,4-5,9,16H2,(H,28,34)(H,29,30,31,32)
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4.06E+3n/an/an/an/an/an/an/an/a



PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn , Bonn, Germany.

Curated by ChEMBL


Assay Description
Displacement of [3H]PSB-12150 from human GPR17 expressed in CHO-K1 cell membranes after 60 mins by heterologous competition binding assay


ACS Med Chem Lett 5: 326-30 (2014)


Article DOI: 10.1021/ml400399f
BindingDB Entry DOI: 10.7270/Q2445P0D
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50161748
PNG
(CHEMBL194085 | [3-((R)-4-Fluoro-benzenesulfonylami...)
Show SMILES OC(=O)Cn1c2CC[C@H](Cc2c2ccccc12)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN2O4S/c21-13-5-8-15(9-6-13)28(26,27)22-14-7-10-19-17(11-14)16-3-1-2-4-18(16)23(19)12-20(24)25/h1-6,8-9,14,22H,7,10-12H2,(H,24,25)/t14-/m1/s1
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5.30E+3n/an/an/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PGD-2 binding to human Prostaglandin D2 receptor


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50161747
PNG
(3-{(R)-3-[(4-Fluoro-benzenesulfonyl)-methyl-amino]...)
Show SMILES CN([C@@H]1CCc2c(C1)c1ccccc1n2CCC(O)=O)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H23FN2O4S/c1-24(30(28,29)17-9-6-15(23)7-10-17)16-8-11-21-19(14-16)18-4-2-3-5-20(18)25(21)13-12-22(26)27/h2-7,9-10,16H,8,11-14H2,1H3,(H,26,27)/t16-/m1/s1
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6.10E+3n/an/an/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PGD-2 binding to human Prostaglandin D2 receptor


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
Uracil nucleotide/cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50052024
PNG
(CHEMBL787 | montelukast)
Show SMILES CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(O)=O)CC1)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1 |r|
Show InChI InChI=1S/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/b15-10+/t32-/m1/s1
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6.54E+3n/an/an/an/an/an/an/an/a



PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn , Bonn, Germany.

Curated by ChEMBL


Assay Description
Displacement of [3H]PSB-12150 from human GPR17 expressed in CHO-K1 cell membranes after 60 mins by heterologous competition binding assay


ACS Med Chem Lett 5: 326-30 (2014)


Article DOI: 10.1021/ml400399f
BindingDB Entry DOI: 10.7270/Q2445P0D
More data for this
Ligand-Target Pair
Prostanoid DP receptor


(Homo sapiens (Human))
BDBM50161746
PNG
((R)-3-(3-(4-fluorophenylsulfonamido)-1,2,3,4-tetra...)
Show SMILES OC(=O)CCn1c2CC[C@H](Cc2c2ccccc12)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PGD-2 binding to human Prostaglandin D2 receptor


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50161745
PNG
(CHEMBL179036 | {3-[((R)-4-Fluoro-benzenesulfonyl)-...)
Show SMILES CN([C@@H]1CCc2c(C1)c1ccccc1n2CC(O)=O)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H21FN2O4S/c1-23(29(27,28)16-9-6-14(22)7-10-16)15-8-11-20-18(12-15)17-4-2-3-5-19(17)24(20)13-21(25)26/h2-7,9-10,15H,8,11-13H2,1H3,(H,25,26)/t15-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of [3H]-SQ-29,548 binding to human Thromboxane A2 receptor


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309317
PNG
(2-(2-(bis(4-fluorophenyl)methyl)-4-(2-fluoropyridi...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccnc(F)c1)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H15F3N2O2S/c24-16-5-1-13(2-6-16)21(14-3-7-17(25)8-4-14)23-28-22(18(31-23)12-20(29)30)15-9-10-27-19(26)11-15/h1-11,21H,12H2,(H,29,30)
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n/an/a 0.480n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50161745
PNG
(CHEMBL179036 | {3-[((R)-4-Fluoro-benzenesulfonyl)-...)
Show SMILES CN([C@@H]1CCc2c(C1)c1ccccc1n2CC(O)=O)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H21FN2O4S/c1-23(29(27,28)16-9-6-14(22)7-10-16)15-8-11-20-18(12-15)17-4-2-3-5-19(17)24(20)13-21(25)26/h2-7,9-10,15H,8,11-13H2,1H3,(H,25,26)/t15-/m1/s1
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of beta-arrestin translocation at human chemoattractant receptor-homologous molecule expressed on TH2 cells in BRET assay


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309297
PNG
(2-(2-(bis(4-fluorophenyl)methyl)-4-(3-fluorophenyl...)
Show SMILES OC(=O)Cc1sc(nc1-c1cccc(F)c1)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C24H16F3NO2S/c25-17-8-4-14(5-9-17)22(15-6-10-18(26)11-7-15)24-28-23(20(31-24)13-21(29)30)16-2-1-3-19(27)12-16/h1-12,22H,13H2,(H,29,30)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50200260
PNG
(4-bromo-2-[1-(4-bromophenyl)-1H-pyrazole-4-carbony...)
Show SMILES OC(=O)COc1ccc(Br)cc1C(=O)c1cnn(c1)-c1ccc(Br)cc1
Show InChI InChI=1S/C18H12Br2N2O4/c19-12-1-4-14(5-2-12)22-9-11(8-21-22)18(25)15-7-13(20)3-6-16(15)26-10-17(23)24/h1-9H,10H2,(H,23,24)
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7TM Pharma

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells


J Med Chem 49: 6638-41 (2006)


Article DOI: 10.1021/jm060657g
BindingDB Entry DOI: 10.7270/Q2DF6QV0
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50200266
PNG
(4-bromo-2-[1-(4-chlorophenyl)-1H-pyrazole-4-carbon...)
Show SMILES OC(=O)COc1ccc(Br)cc1C(=O)c1cnn(c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H12BrClN2O4/c19-12-1-6-16(26-10-17(23)24)15(7-12)18(25)11-8-21-22(9-11)14-4-2-13(20)3-5-14/h1-9H,10H2,(H,23,24)
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7TM Pharma

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells


J Med Chem 49: 6638-41 (2006)


Article DOI: 10.1021/jm060657g
BindingDB Entry DOI: 10.7270/Q2DF6QV0
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50200271
PNG
(4-bromo-2-(1-phenyl-1H-pyrazole-4-carbonyl)phenoxy...)
Show SMILES OC(=O)COc1ccc(Br)cc1C(=O)c1cnn(c1)-c1ccccc1
Show InChI InChI=1S/C18H13BrN2O4/c19-13-6-7-16(25-11-17(22)23)15(8-13)18(24)12-9-20-21(10-12)14-4-2-1-3-5-14/h1-10H,11H2,(H,22,23)
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7TM Pharma

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells


J Med Chem 49: 6638-41 (2006)


Article DOI: 10.1021/jm060657g
BindingDB Entry DOI: 10.7270/Q2DF6QV0
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50200265
PNG
(4-bromo-2-[1-(2-bromophenyl)-1H-pyrazole-4-carbony...)
Show SMILES OC(=O)COc1ccc(Br)cc1C(=O)c1cnn(c1)-c1ccccc1Br
Show InChI InChI=1S/C18H12Br2N2O4/c19-12-5-6-16(26-10-17(23)24)13(7-12)18(25)11-8-21-22(9-11)15-4-2-1-3-14(15)20/h1-9H,10H2,(H,23,24)
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7TM Pharma

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells


J Med Chem 49: 6638-41 (2006)


Article DOI: 10.1021/jm060657g
BindingDB Entry DOI: 10.7270/Q2DF6QV0
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309285
PNG
(2-(2-benzhydryl-4-(3-fluorophenyl)thiazol-5-yl)ace...)
Show SMILES OC(=O)Cc1sc(nc1-c1cccc(F)c1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H18FNO2S/c25-19-13-7-12-18(14-19)23-20(15-21(27)28)29-24(26-23)22(16-8-3-1-4-9-16)17-10-5-2-6-11-17/h1-14,22H,15H2,(H,27,28)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50161745
PNG
(CHEMBL179036 | {3-[((R)-4-Fluoro-benzenesulfonyl)-...)
Show SMILES CN([C@@H]1CCc2c(C1)c1ccccc1n2CC(O)=O)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H21FN2O4S/c1-23(29(27,28)16-9-6-14(22)7-10-16)15-8-11-20-18(12-15)17-4-2-3-5-19(17)24(20)13-21(25)26/h2-7,9-10,15H,8,11-13H2,1H3,(H,25,26)/t15-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of beta-arrestin translocation at human chemoattractant receptor-homologous molecule expressed on TH2 cells in BRET assay


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309320
PNG
(2-(2-(bis(4-fluorophenyl)methyl)-4-(2-methylpyridi...)
Show SMILES Cc1cc(ccn1)-c1nc(sc1CC(O)=O)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C24H18F2N2O2S/c1-14-12-17(10-11-27-14)23-20(13-21(29)30)31-24(28-23)22(15-2-6-18(25)7-3-15)16-4-8-19(26)9-5-16/h2-12,22H,13H2,1H3,(H,29,30)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309318
PNG
(2-(2-(bis(4-fluorophenyl)methyl)-4-(2-chloropyridi...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccnc(Cl)c1)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H15ClF2N2O2S/c24-19-11-15(9-10-27-19)22-18(12-20(29)30)31-23(28-22)21(13-1-5-16(25)6-2-13)14-3-7-17(26)8-4-14/h1-11,21H,12H2,(H,29,30)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Mus musculus (mouse))
BDBM50200271
PNG
(4-bromo-2-(1-phenyl-1H-pyrazole-4-carbonyl)phenoxy...)
Show SMILES OC(=O)COc1ccc(Br)cc1C(=O)c1cnn(c1)-c1ccccc1
Show InChI InChI=1S/C18H13BrN2O4/c19-13-6-7-16(25-11-17(22)23)15(8-13)18(24)12-9-20-21(10-12)14-4-2-1-3-5-14/h1-10H,11H2,(H,22,23)
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n/an/a 3.20n/an/an/an/an/an/a



7TM Pharma

Curated by ChEMBL


Assay Description
Inhibition of mouse CRTH2 receptor


J Med Chem 49: 6638-41 (2006)


Article DOI: 10.1021/jm060657g
BindingDB Entry DOI: 10.7270/Q2DF6QV0
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50200262
PNG
(4-bromo-2-[1-(3-bromophenyl)-1H-pyrazole-4-carbony...)
Show SMILES OC(=O)COc1ccc(Br)cc1C(=O)c1cnn(c1)-c1cccc(Br)c1
Show InChI InChI=1S/C18H12Br2N2O4/c19-12-2-1-3-14(6-12)22-9-11(8-21-22)18(25)15-7-13(20)4-5-16(15)26-10-17(23)24/h1-9H,10H2,(H,23,24)
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7TM Pharma

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells


J Med Chem 49: 6638-41 (2006)


Article DOI: 10.1021/jm060657g
BindingDB Entry DOI: 10.7270/Q2DF6QV0
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309294
PNG
(2-(4-(4-fluorophenyl)-2-((4-hydroxyphenyl)(phenyl)...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccc(F)cc1)C(c1ccccc1)c1ccc(O)cc1
Show InChI InChI=1S/C24H18FNO3S/c25-18-10-6-17(7-11-18)23-20(14-21(28)29)30-24(26-23)22(15-4-2-1-3-5-15)16-8-12-19(27)13-9-16/h1-13,22,27H,14H2,(H,28,29)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309298
PNG
(2-(2-(bis(4-fluorophenyl)methyl)-4-(3,4-difluoroph...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccc(F)c(F)c1)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C24H15F4NO2S/c25-16-6-1-13(2-7-16)22(14-3-8-17(26)9-4-14)24-29-23(20(32-24)12-21(30)31)15-5-10-18(27)19(28)11-15/h1-11,22H,12H2,(H,30,31)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50200247
PNG
(4-bromo-2-[1-(4-methoxyphenyl)-1H-pyrazole-4-carbo...)
Show SMILES COc1ccc(cc1)-n1cc(cn1)C(=O)c1cc(Br)ccc1OCC(O)=O
Show InChI InChI=1S/C19H15BrN2O5/c1-26-15-5-3-14(4-6-15)22-10-12(9-21-22)19(25)16-8-13(20)2-7-17(16)27-11-18(23)24/h2-10H,11H2,1H3,(H,23,24)
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n/an/a 3.60n/an/an/an/an/an/a



7TM Pharma

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells


J Med Chem 49: 6638-41 (2006)


Article DOI: 10.1021/jm060657g
BindingDB Entry DOI: 10.7270/Q2DF6QV0
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309293
PNG
(2-(4-(4-fluorophenyl)-2-((4-methoxyphenyl)(phenyl)...)
Show SMILES COc1ccc(cc1)C(c1nc(c(CC(O)=O)s1)-c1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C25H20FNO3S/c1-30-20-13-9-17(10-14-20)23(16-5-3-2-4-6-16)25-27-24(21(31-25)15-22(28)29)18-7-11-19(26)12-8-18/h2-14,23H,15H2,1H3,(H,28,29)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309399
PNG
(2-(2-(4-chlorobenzyl)-4-(4-phenoxyphenyl)thiazol-5...)
Show SMILES OC(=O)Cc1sc(Cc2ccc(Cl)cc2)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H18ClNO3S/c25-18-10-6-16(7-11-18)14-22-26-24(21(30-22)15-23(27)28)17-8-12-20(13-9-17)29-19-4-2-1-3-5-19/h1-13H,14-15H2,(H,27,28)
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n/an/a 3.70n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50161748
PNG
(CHEMBL194085 | [3-((R)-4-Fluoro-benzenesulfonylami...)
Show SMILES OC(=O)Cn1c2CC[C@H](Cc2c2ccccc12)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN2O4S/c21-13-5-8-15(9-6-13)28(26,27)22-14-7-10-19-17(11-14)16-3-1-2-4-18(16)23(19)12-20(24)25/h1-6,8-9,14,22H,7,10-12H2,(H,24,25)/t14-/m1/s1
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n/an/a 3.80n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of PGD2-induced inositol phosphate formation at human chemoattractant receptor-homologous molecule expressed on TH2 cells


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50161748
PNG
(CHEMBL194085 | [3-((R)-4-Fluoro-benzenesulfonylami...)
Show SMILES OC(=O)Cn1c2CC[C@H](Cc2c2ccccc12)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN2O4S/c21-13-5-8-15(9-6-13)28(26,27)22-14-7-10-19-17(11-14)16-3-1-2-4-18(16)23(19)12-20(24)25/h1-6,8-9,14,22H,7,10-12H2,(H,24,25)/t14-/m1/s1
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of beta-arrestin translocation at human chemoattractant receptor-homologous molecule expressed on TH2 cells in BRET assay


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309295
PNG
(2-(2-(bis(4-methoxyphenyl)methyl)-4-(4-fluoropheny...)
Show SMILES COc1ccc(cc1)C(c1nc(c(CC(O)=O)s1)-c1ccc(F)cc1)c1ccc(OC)cc1
Show InChI InChI=1S/C26H22FNO4S/c1-31-20-11-5-16(6-12-20)24(17-7-13-21(32-2)14-8-17)26-28-25(22(33-26)15-23(29)30)18-3-9-19(27)10-4-18/h3-14,24H,15H2,1-2H3,(H,29,30)
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n/an/a 3.90n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50423390
PNG
(CHEMBL250675 | CHEMBL398303)
Show SMILES OC(=O)Cn1cc(CCN(Cc2ccccc2)S(=O)(=O)c2ccc(F)cc2)c2ccccc12
Show InChI InChI=1S/C25H23FN2O4S/c26-21-10-12-22(13-11-21)33(31,32)28(16-19-6-2-1-3-7-19)15-14-20-17-27(18-25(29)30)24-9-5-4-8-23(20)24/h1-13,17H,14-16,18H2,(H,29,30)
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n/an/a 4n/an/an/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor assessed as inhibition of PGD2-induced signaling by inositol-phosphate assay


Bioorg Med Chem Lett 17: 5924-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.080
BindingDB Entry DOI: 10.7270/Q2DN46BC
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309287
PNG
(2-(2-benzhydryl-4-(3,4-difluorophenyl)thiazol-5-yl...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccc(F)c(F)c1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H17F2NO2S/c25-18-12-11-17(13-19(18)26)23-20(14-21(28)29)30-24(27-23)22(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-13,22H,14H2,(H,28,29)
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n/an/a 4.10n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309317
PNG
(2-(2-(bis(4-fluorophenyl)methyl)-4-(2-fluoropyridi...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccnc(F)c1)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H15F3N2O2S/c24-16-5-1-13(2-6-16)21(14-3-7-17(25)8-4-14)23-28-22(18(31-23)12-20(29)30)15-9-10-27-19(26)11-15/h1-11,21H,12H2,(H,29,30)
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n/an/a 4.70n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309323
PNG
(2-(4-(2-aminopyridin-4-yl)-2-(bis(4-fluorophenyl)m...)
Show SMILES Nc1cc(ccn1)-c1nc(sc1CC(O)=O)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H17F2N3O2S/c24-16-5-1-13(2-6-16)21(14-3-7-17(25)8-4-14)23-28-22(18(31-23)12-20(29)30)15-9-10-27-19(26)11-15/h1-11,21H,12H2,(H2,26,27)(H,29,30)
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n/an/a 4.80n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309316
PNG
(2-(2-(bis(4-fluorophenyl)methyl)-4-(pyridin-4-yl)t...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccncc1)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H16F2N2O2S/c24-17-5-1-14(2-6-17)21(15-3-7-18(25)8-4-15)23-27-22(16-9-11-26-12-10-16)19(30-23)13-20(28)29/h1-12,21H,13H2,(H,28,29)
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n/an/a 5.30n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309319
PNG
(2-(2-(bis(4-fluorophenyl)methyl)-4-(2,6-difluoropy...)
Show SMILES OC(=O)Cc1sc(nc1-c1cc(F)nc(F)c1)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H14F4N2O2S/c24-15-5-1-12(2-6-15)21(13-3-7-16(25)8-4-13)23-29-22(17(32-23)11-20(30)31)14-9-18(26)28-19(27)10-14/h1-10,21H,11H2,(H,30,31)
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n/an/a 5.40n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309296
PNG
(2-(2-(bis(4-fluorophenyl)methyl)-4-(4-fluorophenyl...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccc(F)cc1)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C24H16F3NO2S/c25-17-7-1-14(2-8-17)22(15-3-9-18(26)10-4-15)24-28-23(20(31-24)13-21(29)30)16-5-11-19(27)12-6-16/h1-12,22H,13H2,(H,29,30)
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n/an/a 7.5n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309278
PNG
(2-(4-(4-chlorophenyl)-2-((4-methoxyphenyl)(phenyl)...)
Show SMILES COc1ccc(cc1)C(c1nc(c(CC(O)=O)s1)-c1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1S/C25H20ClNO3S/c1-30-20-13-9-17(10-14-20)23(16-5-3-2-4-6-16)25-27-24(21(31-25)15-22(28)29)18-7-11-19(26)12-8-18/h2-14,23H,15H2,1H3,(H,28,29)
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n/an/a 8.40n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50161746
PNG
((R)-3-(3-(4-fluorophenylsulfonamido)-1,2,3,4-tetra...)
Show SMILES OC(=O)CCn1c2CC[C@H](Cc2c2ccccc12)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1
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n/an/a 8.40n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of beta-arrestin translocation at human Thromboxane A2 receptor in BRET assay


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309284
PNG
(2-(2-benzhydryl-4-(4-fluorophenyl)thiazol-5-yl)ace...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccc(F)cc1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H18FNO2S/c25-19-13-11-18(12-14-19)23-20(15-21(27)28)29-24(26-23)22(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-14,22H,15H2,(H,27,28)
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n/an/a 8.70n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50161746
PNG
((R)-3-(3-(4-fluorophenylsulfonamido)-1,2,3,4-tetra...)
Show SMILES OC(=O)CCn1c2CC[C@H](Cc2c2ccccc12)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1
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n/an/a 9.60n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of U-46,619-induced inositol phosphate accumulation at human Thromboxane A2 receptor


J Med Chem 48: 897-900 (2005)


Article DOI: 10.1021/jm049036i
BindingDB Entry DOI: 10.7270/Q24J0DMD
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50309277
PNG
(2-(2-(bis(4-fluorophenyl)methyl)-4-(4-chlorophenyl...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccc(Cl)cc1)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C24H16ClF2NO2S/c25-17-7-1-16(2-8-17)23-20(13-21(29)30)31-24(28-23)22(14-3-9-18(26)10-4-14)15-5-11-19(27)12-6-15/h1-12,22H,13H2,(H,29,30)
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n/an/a 9.70n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells


Bioorg Med Chem Lett 20: 1181-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.015
BindingDB Entry DOI: 10.7270/Q2PR7W35
More data for this
Ligand-Target Pair
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