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Compile Data Set for Download or QSAR

Found 6 hits with Last Name = 'kottra' and Initial = 'g'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50242614
PNG
((S)-1-((S)-2-((S)-2,5-diamino-5-oxopentanamido)-3-...)
Show SMILES N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(O)=O |r|
Show InChI InChI=1S/C13H22N4O6/c14-7(3-4-10(15)19)11(20)16-8(6-18)12(21)17-5-1-2-9(17)13(22)23/h7-9,18H,1-6,14H2,(H2,15,19)(H,16,20)(H,22,23)/t7-,8-,9-/m0/s1
UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.160n/an/an/an/an/an/a



University Würzburg

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in xenopus laevis oocyte assessed as inhibition of methyl-alpha-D-[14C]glucopyranoside uptake after 1 hrs


J Biol Chem 282: 28501-13 (2007)


Article DOI: 10.1074/jbc.M705416200
BindingDB Entry DOI: 10.7270/Q2SJ1KCM
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50242617
PNG
(CHEMBL521026 | QSPac)
Show SMILES CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(O)=O |r|
Show InChI InChI=1S/C15H24N4O7/c1-8(21)19-6-2-3-11(19)14(24)18-10(7-20)13(23)17-9(15(25)26)4-5-12(16)22/h9-11,20H,2-7H2,1H3,(H2,16,22)(H,17,23)(H,18,24)(H,25,26)/t9-,10-,11-/m0/s1
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KEGG
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.170n/an/an/an/an/an/a



University Würzburg

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in xenopus laevis oocyte assessed as inhibition of methyl-alpha-D-[14C]glucopyranoside uptake after 1 hrs


J Biol Chem 282: 28501-13 (2007)


Article DOI: 10.1074/jbc.M705416200
BindingDB Entry DOI: 10.7270/Q2SJ1KCM
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50242615
PNG
(CHEMBL486028 | QCPac)
Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CS)C(O)=O |r|
Show InChI InChI=1S/C13H21N3O5S/c1-7(11(18)15-9(6-22)13(20)21)14-12(19)10-4-3-5-16(10)8(2)17/h7,9-10,22H,3-6H2,1-2H3,(H,14,19)(H,15,18)(H,20,21)/t7-,9-,10-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



University Würzburg

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in xenopus laevis oocyte assessed as inhibition of methyl-alpha-D-[14C]glucopyranoside uptake after 1 hrs


J Biol Chem 282: 28501-13 (2007)


Article DOI: 10.1074/jbc.M705416200
BindingDB Entry DOI: 10.7270/Q2SJ1KCM
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50242616
PNG
(CHEMBL485831 | QCP)
Show SMILES N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(O)=O |r|
Show InChI InChI=1S/C13H22N4O5S/c14-7(3-4-10(15)18)11(19)16-8(6-23)12(20)17-5-1-2-9(17)13(21)22/h7-9,23H,1-6,14H2,(H2,15,18)(H,16,19)(H,21,22)/t7-,8-,9-/m0/s1
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
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n/an/a 2.10n/an/an/an/an/an/a



University Würzburg

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in xenopus laevis oocyte assessed as inhibition of methyl-alpha-D-[14C]glucopyranoside uptake after 1 hrs


J Biol Chem 282: 28501-13 (2007)


Article DOI: 10.1074/jbc.M705416200
BindingDB Entry DOI: 10.7270/Q2SJ1KCM
More data for this
Ligand-Target Pair
Oligopeptide transporter small intestine isoform


(Homo sapiens (Human))
BDBM50341599
PNG
((S)-2-((S)-2-amino-3-(2,5,7-tri-tert-butyl-1H-indo...)
Show SMILES CC(C)(C)c1[nH]c2c(cc(cc2c1C[C@H](N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)C(C)(C)C)C(C)(C)C |r|
Show InChI InChI=1S/C29H49N7O2/c1-27(2,3)16-13-17-18(23(29(7,8)9)36-22(17)19(14-16)28(4,5)6)15-20(30)25(38)35-21(24(31)37)11-10-12-34-26(32)33/h13-14,20-21,36H,10-12,15,30H2,1-9H3,(H2,31,37)(H,35,38)(H4,32,33,34)/t20-,21-/m0/s1
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.00E+5n/an/an/an/an/an/a



University of Troms£

Curated by ChEMBL


Assay Description
Inhibition of human PEPT1 expressed in Xenopus laevis oocytes assessed as inhibition of glycylsarcosine-induced transport-associated current at -60 m...


J Med Chem 54: 2422-32 (2011)


Article DOI: 10.1021/jm1015704
BindingDB Entry DOI: 10.7270/Q2T153Z3
More data for this
Ligand-Target Pair
Oligopeptide transporter small intestine isoform


(Homo sapiens (Human))
BDBM50341600
PNG
((S)-2-amino-N-((S)-1-((S)-1-amino-5-guanidino-1-ox...)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C23H37N11O3/c24-15(6-3-9-30-22(26)27)20(36)34-18(11-13-12-32-16-7-2-1-5-14(13)16)21(37)33-17(19(25)35)8-4-10-31-23(28)29/h1-2,5,7,12,15,17-18,32H,3-4,6,8-11,24H2,(H2,25,35)(H,33,37)(H,34,36)(H4,26,27,30)(H4,28,29,31)/t15-,17-,18-/m0/s1
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KEGG

UniProtKB/SwissProt

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GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.70E+6n/an/an/an/an/an/a



University of Troms£

Curated by ChEMBL


Assay Description
Inhibition of human PEPT1 expressed in Xenopus laevis oocytes assessed as inhibition of glycylsarcosine-induced transport-associated current at -60 m...


J Med Chem 54: 2422-32 (2011)


Article DOI: 10.1021/jm1015704
BindingDB Entry DOI: 10.7270/Q2T153Z3
More data for this
Ligand-Target Pair