new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 12 hits with Last Name = 'lópez' and Initial = 'fj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Androgen Receptor


(Homo sapiens (Human))
BDBM18161
PNG
((1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethy...)
Show SMILES [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])CC(=O)CC[C@]12C |r|
Show InChI InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

PDB
Article
PubMed
0.200 -57.6n/an/a 5.10n/an/a7.437



Ligand Pharmaceuticals Inc.



Assay Description
The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...


J Med Chem 49: 6143-6 (2006)


Article DOI: 10.1021/jm060792t
BindingDB Entry DOI: 10.7270/Q26971VV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Androgen Receptor


(Homo sapiens (Human))
BDBM18530
PNG
(6-(diethylamino)-4-(trifluoromethyl)-1,2-dihydroqu...)
Show SMILES CCN(CC)c1ccc2[nH]c(=O)cc(c2c1)C(F)(F)F
Show InChI InChI=1S/C14H15F3N2O/c1-3-19(4-2)9-5-6-12-10(7-9)11(14(15,16)17)8-13(20)18-12/h5-8H,3-4H2,1-2H3,(H,18,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
4.40 -49.6n/an/a 2.10n/an/a7.437



Ligand Pharmaceuticals Inc.



Assay Description
The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...


J Med Chem 49: 6143-6 (2006)


Article DOI: 10.1021/jm060792t
BindingDB Entry DOI: 10.7270/Q26971VV
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM18534
PNG
(6-[bis(cyclopropylmethyl)amino]-4-(trifluoromethyl...)
Show SMILES FC(F)(F)c1cc(=O)[nH]c2ccc(cc12)N(CC1CC1)CC1CC1
Show InChI InChI=1S/C18H19F3N2O/c19-18(20,21)15-8-17(24)22-16-6-5-13(7-14(15)16)23(9-11-1-2-11)10-12-3-4-12/h5-8,11-12H,1-4,9-10H2,(H,22,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
6.30 -48.7n/an/a 1.90n/an/a7.437



Ligand Pharmaceuticals Inc.



Assay Description
The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...


J Med Chem 49: 6143-6 (2006)


Article DOI: 10.1021/jm060792t
BindingDB Entry DOI: 10.7270/Q26971VV
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM18536
PNG
(6-[(cyclopropylmethyl)(2,2,2-trifluoroethyl)amino]...)
Show SMILES FC(F)(F)CN(CC1CC1)c1ccc2[nH]c(=O)cc(c2c1)C(F)(F)F
Show InChI InChI=1S/C16H14F6N2O/c17-15(18,19)8-24(7-9-1-2-9)10-3-4-13-11(5-10)12(16(20,21)22)6-14(25)23-13/h3-6,9H,1-2,7-8H2,(H,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
7.10 -48.4n/an/a 2.80n/an/a7.437



Ligand Pharmaceuticals Inc.



Assay Description
The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...


J Med Chem 49: 6143-6 (2006)


Article DOI: 10.1021/jm060792t
BindingDB Entry DOI: 10.7270/Q26971VV
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM18535
PNG
(6-[ethyl(2,2,2-trifluoroethyl)amino]-4-(trifluorom...)
Show SMILES CCN(CC(F)(F)F)c1ccc2[nH]c(=O)cc(c2c1)C(F)(F)F
Show InChI InChI=1S/C14H12F6N2O/c1-2-22(7-13(15,16)17)8-3-4-11-9(5-8)10(14(18,19)20)6-12(23)21-11/h3-6H,2,7H2,1H3,(H,21,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
7.10 -48.4n/an/a 0.400n/an/a7.437



Ligand Pharmaceuticals Inc.



Assay Description
The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...


J Med Chem 49: 6143-6 (2006)


Article DOI: 10.1021/jm060792t
BindingDB Entry DOI: 10.7270/Q26971VV
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM18533
PNG
(6-[ethyl(propan-2-yl)amino]-4-(trifluoromethyl)-1,...)
Show SMILES CCN(C(C)C)c1ccc2[nH]c(=O)cc(c2c1)C(F)(F)F
Show InChI InChI=1S/C15H17F3N2O/c1-4-20(9(2)3)10-5-6-13-11(7-10)12(15(16,17)18)8-14(21)19-13/h5-9H,4H2,1-3H3,(H,19,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
7.40 -48.3n/an/a 2.20n/an/a7.437



Ligand Pharmaceuticals Inc.



Assay Description
The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...


J Med Chem 49: 6143-6 (2006)


Article DOI: 10.1021/jm060792t
BindingDB Entry DOI: 10.7270/Q26971VV
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM18527
PNG
(6-(propylamino)-4-(trifluoromethyl)-1,2-dihydroqui...)
Show SMILES CCCNc1ccc2[nH]c(=O)cc(c2c1)C(F)(F)F
Show InChI InChI=1S/C13H13F3N2O/c1-2-5-17-8-3-4-11-9(6-8)10(13(14,15)16)7-12(19)18-11/h3-4,6-7,17H,2,5H2,1H3,(H,18,19)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
54 -43.2 27.5n/a 2.02E+3n/an/a7.437



Ligand Pharmaceuticals Inc.



Assay Description
The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...


J Med Chem 49: 6143-6 (2006)


Article DOI: 10.1021/jm060792t
BindingDB Entry DOI: 10.7270/Q26971VV
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM18528
PNG
(6-(propan-2-ylamino)-4-(trifluoromethyl)-1,2-dihyd...)
Show SMILES CC(C)Nc1ccc2[nH]c(=O)cc(c2c1)C(F)(F)F
Show InChI InChI=1S/C13H13F3N2O/c1-7(2)17-8-3-4-11-9(5-8)10(13(14,15)16)6-12(19)18-11/h3-7,17H,1-2H3,(H,18,19)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
58 -43.0 16.5n/a 106n/an/a7.437



Ligand Pharmaceuticals Inc.



Assay Description
The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...


J Med Chem 49: 6143-6 (2006)


Article DOI: 10.1021/jm060792t
BindingDB Entry DOI: 10.7270/Q26971VV
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM18531
PNG
(6-(dipropylamino)-4-(trifluoromethyl)-1,2-dihydroq...)
Show SMILES CCCN(CCC)c1ccc2[nH]c(=O)cc(c2c1)C(F)(F)F
Show InChI InChI=1S/C16H19F3N2O/c1-3-7-21(8-4-2)11-5-6-14-12(9-11)13(16(17,18)19)10-15(22)20-14/h5-6,9-10H,3-4,7-8H2,1-2H3,(H,20,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
64 -42.7n/an/a 1.5n/an/a7.437



Ligand Pharmaceuticals Inc.



Assay Description
The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...


J Med Chem 49: 6143-6 (2006)


Article DOI: 10.1021/jm060792t
BindingDB Entry DOI: 10.7270/Q26971VV
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM18529
PNG
(6-(dimethylamino)-4-(trifluoromethyl)-1,2-dihydroq...)
Show SMILES CN(C)c1ccc2[nH]c(=O)cc(c2c1)C(F)(F)F
Show InChI InChI=1S/C12H11F3N2O/c1-17(2)7-3-4-10-8(5-7)9(12(13,14)15)6-11(18)16-10/h3-6H,1-2H3,(H,16,18)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
153 -40.5 34n/an/an/an/a7.437



Ligand Pharmaceuticals Inc.



Assay Description
The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...


J Med Chem 49: 6143-6 (2006)


Article DOI: 10.1021/jm060792t
BindingDB Entry DOI: 10.7270/Q26971VV
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM18532
PNG
(6-(dibutylamino)-4-(trifluoromethyl)-1,2-dihydroqu...)
Show SMILES CCCCN(CCCC)c1ccc2[nH]c(=O)cc(c2c1)C(F)(F)F
Show InChI InChI=1S/C18H23F3N2O/c1-3-5-9-23(10-6-4-2)13-7-8-16-14(11-13)15(18(19,20)21)12-17(24)22-16/h7-8,11-12H,3-6,9-10H2,1-2H3,(H,22,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
222 -39.5 29.5n/a 1.28E+3n/an/a7.437



Ligand Pharmaceuticals Inc.



Assay Description
The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...


J Med Chem 49: 6143-6 (2006)


Article DOI: 10.1021/jm060792t
BindingDB Entry DOI: 10.7270/Q26971VV
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM18526
PNG
(6-amino-4-(trifluoromethyl)-1,2-dihydroquinolin-2-...)
Show SMILES Nc1ccc2[nH]c(=O)cc(c2c1)C(F)(F)F
Show InChI InChI=1S/C10H7F3N2O/c11-10(12,13)7-4-9(16)15-8-2-1-5(14)3-6(7)8/h1-4H,14H2,(H,15,16)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

Article
PubMed
>1.00E+4>-29.7 26n/an/an/an/a7.437



Ligand Pharmaceuticals Inc.



Assay Description
The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...


J Med Chem 49: 6143-6 (2006)


Article DOI: 10.1021/jm060792t
BindingDB Entry DOI: 10.7270/Q26971VV
More data for this
Ligand-Target Pair