new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 664 hits with Last Name = 'lamb' and Initial = 'dj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM375967
PNG
(US9914735, Example 45)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
n/an/a 0.200n/an/an/an/an/an/a



University of Namur





J Med Chem 51: 3077-80 (2008)


Article DOI: 10.1021/jm8002697
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140390
PNG
(US8912173, 115 | US9914735, Example 115)
Show SMILES CC(C)n1cc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1/C21H24N4O2/c1-13(2)25-12-17(11-24-25)15-7-19-18(5-4-6-22-19)20(8-15)27-14(3)16-9-21(26)23-10-16/h4-8,11-14,16H,9-10H2,1-3H3,(H,23,26)/t14-,16-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
n/an/a 0.200n/an/an/an/an/an/a



University of Namur





J Med Chem 51: 3077-80 (2008)


Article DOI: 10.1021/jm8002697
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140389
PNG
(US8912173, 114 | US9914735, Example 114)
Show SMILES CCCn1cc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1/C21H24N4O2/c1-3-7-25-13-17(12-24-25)15-8-19-18(5-4-6-22-19)20(9-15)27-14(2)16-10-21(26)23-11-16/h4-6,8-9,12-14,16H,3,7,10-11H2,1-2H3,(H,23,26)/t14-,16-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
n/an/a 0.200n/an/an/an/an/an/a



University of Namur





J Med Chem 51: 3077-80 (2008)


Article DOI: 10.1021/jm8002697
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173054
PNG
(US9096579, 156)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1ccccn1
Show InChI InChI=1S/C24H22N8O/c1-15-9-18(29-24-26-8-6-19(31-24)21-13-32(2)14-28-21)10-16-11-20(30-22(15)16)23(33)27-12-17-5-3-4-7-25-17/h3-11,13-14,30H,12H2,1-2H3,(H,27,33)(H,26,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172902
PNG
(US9096579, 4)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(N)=O
Show InChI InChI=1S/C18H17N7O/c1-10-5-12(6-11-7-14(17(19)26)23-16(10)11)22-18-20-4-3-13(24-18)15-8-25(2)9-21-15/h3-9,23H,1-2H3,(H2,19,26)(H,20,22,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173073
PNG
(US9096579, 175)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)-c1nnco1
Show InChI InChI=1S/C19H16N8O/c1-11-5-13(6-12-7-15(24-17(11)12)18-26-22-10-28-18)23-19-20-4-3-14(25-19)16-8-27(2)9-21-16/h3-10,24H,1-2H3,(H,20,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172932
PNG
(US9096579, 34)
Show SMILES CN1C(=O)COCC11CCN(CC1)C(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C27H30N8O3/c1-17-10-19(30-26-28-7-4-20(32-26)22-13-33(2)16-29-22)11-18-12-21(31-24(17)18)25(37)35-8-5-27(6-9-35)15-38-14-23(36)34(27)3/h4,7,10-13,16,31H,5-6,8-9,14-15H2,1-3H3,(H,28,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172939
PNG
(US9096579, 41)
Show SMILES CCN(CC)C1CN(C1)C(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(Cl)c2[nH]1
Show InChI InChI=1S/C24H27ClN8O/c1-4-32(5-2)17-11-33(12-17)23(34)20-9-15-8-16(10-18(25)22(15)29-20)28-24-26-7-6-19(30-24)21-13-31(3)14-27-21/h6-10,13-14,17,29H,4-5,11-12H2,1-3H3,(H,26,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173021
PNG
(US9096579, 123)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1nc2ccncc2[nH]1
Show InChI InChI=1S/C25H22N10O/c1-14-7-16(30-25-27-6-4-18(34-25)21-12-35(2)13-29-21)8-15-9-19(33-23(14)15)24(36)28-11-22-31-17-3-5-26-10-20(17)32-22/h3-10,12-13,33H,11H2,1-2H3,(H,28,36)(H,31,32)(H,27,30,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173008
PNG
(US9096579, 110)
Show SMILES CCn1ccc(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)n1
Show InChI InChI=1S/C24H25N9O/c1-4-33-8-6-17(31-33)12-26-23(34)20-11-16-10-18(9-15(2)22(16)29-20)28-24-25-7-5-19(30-24)21-13-32(3)14-27-21/h5-11,13-14,29H,4,12H2,1-3H3,(H,26,34)(H,25,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172947
PNG
(US9096579, 49)
Show SMILES CN1C(=O)COCC11CCN(CC1)C(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(Cl)c2[nH]1
Show InChI InChI=1S/C26H27ClN8O3/c1-33-12-21(29-15-33)19-3-6-28-25(32-19)30-17-9-16-10-20(31-23(16)18(27)11-17)24(37)35-7-4-26(5-8-35)14-38-13-22(36)34(26)2/h3,6,9-12,15,31H,4-5,7-8,13-14H2,1-2H3,(H,28,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.700n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173019
PNG
(US9096579, 121)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1ccccc1F
Show InChI InChI=1S/C25H22FN7O/c1-15-9-18(30-25-27-8-7-20(32-25)22-13-33(2)14-29-22)10-17-11-21(31-23(15)17)24(34)28-12-16-5-3-4-6-19(16)26/h3-11,13-14,31H,12H2,1-2H3,(H,28,34)(H,27,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172943
PNG
(US9096579, 45)
Show SMILES CN1CCN(C2CCN(CC2)C(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(Cl)c3[nH]2)C1=O
Show InChI InChI=1S/C26H28ClN9O2/c1-33-14-22(29-15-33)20-3-6-28-25(32-20)30-17-11-16-12-21(31-23(16)19(27)13-17)24(37)35-7-4-18(5-8-35)36-10-9-34(2)26(36)38/h3,6,11-15,18,31H,4-5,7-10H2,1-2H3,(H,28,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173073
PNG
(US9096579, 175)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)-c1nnco1
Show InChI InChI=1S/C19H16N8O/c1-11-5-13(6-12-7-15(24-17(11)12)18-26-22-10-28-18)23-19-20-4-3-14(25-19)16-8-27(2)9-21-16/h3-10,24H,1-2H3,(H,20,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173010
PNG
(US9096579, 112)
Show SMILES Cc1c(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)cnn1C
Show InChI InChI=1S/C24H25N9O/c1-14-7-18(29-24-25-6-5-19(31-24)21-12-32(3)13-27-21)8-16-9-20(30-22(14)16)23(34)26-10-17-11-28-33(4)15(17)2/h5-9,11-13,30H,10H2,1-4H3,(H,26,34)(H,25,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172927
PNG
(US9096579, 29)
Show SMILES CC(C)n1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)N2CCN(C)CC2)n1
Show InChI InChI=1S/C24H27ClN8O/c1-15(2)33-13-21(27-14-33)19-4-5-26-24(30-19)28-17-10-16-11-20(29-22(16)18(25)12-17)23(34)32-8-6-31(3)7-9-32/h4-5,10-15,29H,6-9H2,1-3H3,(H,26,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172906
PNG
(US9096579, 8)
Show SMILES CNC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C19H19N7O/c1-11-6-13(7-12-8-15(18(27)20-2)24-17(11)12)23-19-21-5-4-14(25-19)16-9-26(3)10-22-16/h4-10,24H,1-3H3,(H,20,27)(H,21,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172915
PNG
(US9096579, 17)
Show SMILES CC(C)n1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)N(C)C)n1
Show InChI InChI=1S/C21H22ClN7O/c1-12(2)29-10-18(24-11-29)16-5-6-23-21(27-16)25-14-7-13-8-17(20(30)28(3)4)26-19(13)15(22)9-14/h5-12,26H,1-4H3,(H,23,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172902
PNG
(US9096579, 4)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(N)=O
Show InChI InChI=1S/C18H17N7O/c1-10-5-12(6-11-7-14(17(19)26)23-16(10)11)22-18-20-4-3-13(24-18)15-8-25(2)9-21-15/h3-9,23H,1-2H3,(H2,19,26)(H,20,22,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM375942
PNG
(US9914735, Example 8)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
n/an/a 1n/an/an/an/an/an/a



University of Namur





J Med Chem 51: 3077-80 (2008)


Article DOI: 10.1021/jm8002697
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140369
PNG
(US8912173, 94 | US9914735, Example 94)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2n(C)cnc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C23H22N4O2/c1-14(17-11-23(28)25-12-17)29-22-10-16(9-19-18(22)4-3-7-24-19)15-5-6-21-20(8-15)26-13-27(21)2/h3-10,13-14,17H,11-12H2,1-2H3,(H,25,28)/t14-,17-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
n/an/a 1n/an/an/an/an/an/a



University of Namur





J Med Chem 51: 3077-80 (2008)


Article DOI: 10.1021/jm8002697
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172906
PNG
(US9096579, 8)
Show SMILES CNC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C19H19N7O/c1-11-6-13(7-12-8-15(18(27)20-2)24-17(11)12)23-19-21-5-4-14(25-19)16-9-26(3)10-22-16/h4-10,24H,1-3H3,(H,20,27)(H,21,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM375964
PNG
(US9914735, Example 41)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
n/an/a 1n/an/an/an/an/an/a



University of Namur





J Med Chem 51: 3077-80 (2008)


Article DOI: 10.1021/jm8002697
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140384
PNG
(US8912173, 109 | US9914735, Example 109)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2[nH]c(C)nc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C23H22N4O2/c1-13(17-11-23(28)25-12-17)29-22-10-16(9-20-18(22)4-3-7-24-20)15-5-6-19-21(8-15)27-14(2)26-19/h3-10,13,17H,11-12H2,1-2H3,(H,25,28)(H,26,27)/t13-,17-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
n/an/a 1n/an/an/an/an/an/a



University of Namur





J Med Chem 51: 3077-80 (2008)


Article DOI: 10.1021/jm8002697
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM375960
PNG
(US9914735, Example 35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
n/an/a 1n/an/an/an/an/an/a



University of Namur





J Med Chem 51: 3077-80 (2008)


Article DOI: 10.1021/jm8002697
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM375942
PNG
(US9914735, Example 8)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
n/an/a 1n/an/an/an/an/an/a



University of Namur





J Med Chem 51: 3077-80 (2008)


Article DOI: 10.1021/jm8002697
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140380
PNG
(US8912173, 105 | US9914735, Example 105)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2n(C)c(C)nc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C24H24N4O2/c1-14(18-12-24(29)26-13-18)30-23-11-17(10-20-19(23)5-4-8-25-20)16-6-7-22-21(9-16)27-15(2)28(22)3/h4-11,14,18H,12-13H2,1-3H3,(H,26,29)/t14-,18-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
n/an/a 1n/an/an/an/an/an/a



University of Namur





J Med Chem 51: 3077-80 (2008)


Article DOI: 10.1021/jm8002697
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM375944
PNG
(Step 1: Synthesis of N′-(4,4-difluoro-cycloh...)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
n/an/a 1n/an/an/an/an/an/a



University of Namur





J Med Chem 51: 3077-80 (2008)


Article DOI: 10.1021/jm8002697
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM375966
PNG
(US9914735, Example 43)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
n/an/a 1n/an/an/an/an/an/a



University of Namur





J Med Chem 51: 3077-80 (2008)


Article DOI: 10.1021/jm8002697
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172951
PNG
(US9096579, 53)
Show SMILES Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)N2CCC(CC2)N2CCCC2=O)n1
Show InChI InChI=1S/C26H27ClN8O2/c1-33-14-22(29-15-33)20-4-7-28-26(32-20)30-17-11-16-12-21(31-24(16)19(27)13-17)25(37)34-9-5-18(6-10-34)35-8-2-3-23(35)36/h4,7,11-15,18,31H,2-3,5-6,8-10H2,1H3,(H,28,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173054
PNG
(US9096579, 156)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1ccccn1
Show InChI InChI=1S/C24H22N8O/c1-15-9-18(29-24-26-8-6-19(31-24)21-13-32(2)14-28-21)10-16-11-20(30-22(15)16)23(33)27-12-17-5-3-4-7-25-17/h3-11,13-14,30H,12H2,1-2H3,(H,27,33)(H,26,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172913
PNG
(US9096579, 15)
Show SMILES CN(C)C(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(Br)c2[nH]1
Show InChI InChI=1S/C19H18BrN7O/c1-26(2)18(28)15-7-11-6-12(8-13(20)17(11)24-15)23-19-21-5-4-14(25-19)16-9-27(3)10-22-16/h4-10,24H,1-3H3,(H,21,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173043
PNG
(US9096579, 145)
Show SMILES Cc1nn(C)cc1CNC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C24H25N9O/c1-14-7-18(28-24-25-6-5-19(30-24)21-12-32(3)13-27-21)8-16-9-20(29-22(14)16)23(34)26-10-17-11-33(4)31-15(17)2/h5-9,11-13,29H,10H2,1-4H3,(H,26,34)(H,25,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173001
PNG
(US9096579, 103)
Show SMILES Cc1cc(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)n(C)n1
Show InChI InChI=1S/C24H25N9O/c1-14-7-17(28-24-25-6-5-19(30-24)21-12-32(3)13-27-21)9-16-10-20(29-22(14)16)23(34)26-11-18-8-15(2)31-33(18)4/h5-10,12-13,29H,11H2,1-4H3,(H,26,34)(H,25,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173018
PNG
(US9096579, 120)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1nc2ccccc2n1C
Show InChI InChI=1S/C27H25N9O/c1-16-10-18(31-27-28-9-8-19(34-27)22-14-35(2)15-30-22)11-17-12-21(33-25(16)17)26(37)29-13-24-32-20-6-4-5-7-23(20)36(24)3/h4-12,14-15,33H,13H2,1-3H3,(H,29,37)(H,28,31,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172952
PNG
(US9096579, 54)
Show SMILES CN1CCC2(CCN(C2)C(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(Cl)c3[nH]2)C1
Show InChI InChI=1/C25H27ClN8O/c1-32-7-4-25(13-32)5-8-34(14-25)23(35)20-10-16-9-17(11-18(26)22(16)30-20)29-24-27-6-3-19(31-24)21-12-33(2)15-28-21/h3,6,9-12,15,30H,4-5,7-8,13-14H2,1-2H3,(H,27,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173071
PNG
(US9096579, 173)
Show SMILES Cc1nnc(o1)-c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C20H18N8O/c1-11-6-14(7-13-8-16(24-18(11)13)19-27-26-12(2)29-19)23-20-21-5-4-15(25-20)17-9-28(3)10-22-17/h4-10,24H,1-3H3,(H,21,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173069
PNG
(US9096579, 171)
Show SMILES Cc1noc(n1)-c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C20H18N8O/c1-11-6-14(7-13-8-16(25-18(11)13)19-23-12(2)27-29-19)24-20-21-5-4-15(26-20)17-9-28(3)10-22-17/h4-10,25H,1-3H3,(H,21,24,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172953
PNG
(US9096579, 55)
Show SMILES CN(CC1CCOCC1)C(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(Cl)c2[nH]1
Show InChI InChI=1S/C24H26ClN7O2/c1-31-13-21(27-14-31)19-3-6-26-24(30-19)28-17-9-16-10-20(29-22(16)18(25)11-17)23(33)32(2)12-15-4-7-34-8-5-15/h3,6,9-11,13-15,29H,4-5,7-8,12H2,1-2H3,(H,26,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172940
PNG
(US9096579, 42)
Show SMILES Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)NCC2CCOCC2)n1
Show InChI InChI=1S/C23H24ClN7O2/c1-31-12-20(27-13-31)18-2-5-25-23(30-18)28-16-8-15-9-19(29-21(15)17(24)10-16)22(32)26-11-14-3-6-33-7-4-14/h2,5,8-10,12-14,29H,3-4,6-7,11H2,1H3,(H,26,32)(H,25,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172905
PNG
(US9096579, 7)
Show SMILES CNC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(Cl)c2[nH]1
Show InChI InChI=1S/C18H16ClN7O/c1-20-17(27)14-6-10-5-11(7-12(19)16(10)24-14)23-18-21-4-3-13(25-18)15-8-26(2)9-22-15/h3-9,24H,1-2H3,(H,20,27)(H,21,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173005
PNG
(US9096579, 107)
Show SMILES Cc1cnc(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)s1
Show InChI InChI=1S/C23H22N8OS/c1-13-6-16(28-23-24-5-4-17(30-23)19-11-31(3)12-27-19)7-15-8-18(29-21(13)15)22(32)26-10-20-25-9-14(2)33-20/h4-9,11-12,29H,10H2,1-3H3,(H,26,32)(H,24,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172993
PNG
(US9096579, 95)
Show SMILES COC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C19H18N6O2/c1-11-6-13(7-12-8-15(18(26)27-3)23-17(11)12)22-19-20-5-4-14(24-19)16-9-25(2)10-21-16/h4-10,23H,1-3H3,(H,20,22,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172904
PNG
(US9096579, 6)
Show SMILES CN(C)C(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(Cl)c2[nH]1
Show InChI InChI=1S/C19H18ClN7O/c1-26(2)18(28)15-7-11-6-12(8-13(20)17(11)24-15)23-19-21-5-4-14(25-19)16-9-27(3)10-22-16/h4-10,24H,1-3H3,(H,21,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173063
PNG
(US9096579, 165)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1cccnc1
Show InChI InChI=1S/C24H22N8O/c1-15-8-18(29-24-26-7-5-19(31-24)21-13-32(2)14-28-21)9-17-10-20(30-22(15)17)23(33)27-12-16-4-3-6-25-11-16/h3-11,13-14,30H,12H2,1-2H3,(H,27,33)(H,26,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172928
PNG
(US9096579, 30)
Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Nc3nccc(n3)-c3cn(cn3)C3CC3)cc(Cl)c2[nH]1
Show InChI InChI=1S/C24H25ClN8O/c1-31-6-8-32(9-7-31)23(34)20-11-15-10-16(12-18(25)22(15)29-20)28-24-26-5-4-19(30-24)21-13-33(14-27-21)17-2-3-17/h4-5,10-14,17,29H,2-3,6-9H2,1H3,(H,26,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172945
PNG
(US9096579, 47)
Show SMILES Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)N2CCC(CC2)N2CCS(=O)CC2)n1
Show InChI InChI=1S/C26H29ClN8O2S/c1-33-15-23(29-16-33)21-2-5-28-26(32-21)30-18-12-17-13-22(31-24(17)20(27)14-18)25(36)35-6-3-19(4-7-35)34-8-10-38(37)11-9-34/h2,5,12-16,19,31H,3-4,6-11H2,1H3,(H,28,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172901
PNG
(US9096579, 3)
Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(Cl)c2[nH]1
Show InChI InChI=1S/C22H23ClN8O/c1-29-5-7-31(8-6-29)21(32)18-10-14-9-15(11-16(23)20(14)27-18)26-22-24-4-3-17(28-22)19-12-30(2)13-25-19/h3-4,9-13,27H,5-8H2,1-2H3,(H,24,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172964
PNG
(US9096579, 66)
Show SMILES Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)NCc2nccn2C)n1
Show InChI InChI=1S/C22H20ClN9O/c1-31-11-18(27-12-31)16-3-4-25-22(30-16)28-14-7-13-8-17(29-20(13)15(23)9-14)21(33)26-10-19-24-5-6-32(19)2/h3-9,11-12,29H,10H2,1-2H3,(H,26,33)(H,25,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173008
PNG
(US9096579, 110)
Show SMILES CCn1ccc(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)n1
Show InChI InChI=1S/C24H25N9O/c1-4-33-8-6-17(31-33)12-26-23(34)20-11-16-10-18(9-15(2)22(16)29-20)28-24-25-7-5-19(30-24)21-13-32(3)14-27-21/h5-11,13-14,29H,4,12H2,1-3H3,(H,26,34)(H,25,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 664 total )  |  Next  |  Last  >>
Jump to: