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Compile Data Set for Download or QSAR

Found 627 hits with Last Name = 'liu' and Initial = 'kg'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334730
PNG
(3-(Naphthalen-1-ylsulfonyl)-5-(piperazin-1-ylmethy...)
Show SMILES O=S(=O)(c1n[nH]c2ccc(CN3CCNCC3)cc12)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O2S/c27-29(28,21-7-3-5-17-4-1-2-6-18(17)21)22-19-14-16(8-9-20(19)24-25-22)15-26-12-10-23-11-13-26/h1-9,14,23H,10-13,15H2,(H,24,25)
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0.240n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM28574
PNG
(1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...)
Show SMILES NCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C20H18N4O3S/c21-11-10-20(25)23-16-9-8-15-13-22-24(18(15)12-16)28(26,27)19-7-3-5-14-4-1-2-6-17(14)19/h1-9,12-13H,10-11,21H2,(H,23,25)
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0.5 -52.6n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334734
PNG
(3-(Naphthalen-2-ylsulfonyl)-N-(piperidin-4-yl)-1H-...)
Show SMILES O=S(=O)(c1n[nH]c2ccc(NC3CCNCC3)cc12)c1ccc2ccccc2c1
Show InChI InChI=1S/C22H22N4O2S/c27-29(28,19-7-5-15-3-1-2-4-16(15)13-19)22-20-14-18(6-8-21(20)25-26-22)24-17-9-11-23-12-10-17/h1-8,13-14,17,23-24H,9-12H2,(H,25,26)
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0.600n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334731
PNG
(CHEMBL1642851 | [3-(Naphthalen-1-sulfonyl)-1H-inda...)
Show SMILES O=S(=O)(c1n[nH]c2ccc(NC3CCNCC3)cc12)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O2S/c27-29(28,21-7-3-5-15-4-1-2-6-18(15)21)22-19-14-17(8-9-20(19)25-26-22)24-16-10-12-23-13-11-16/h1-9,14,16,23-24H,10-13H2,(H,25,26)
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0.700n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334754
PNG
(CHEMBL1642883 | N-(Piperidin-4-yl)-3-(m-tolylsulfo...)
Show SMILES Cc1cccc(c1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Show InChI InChI=1S/C19H22N4O2S/c1-13-3-2-4-16(11-13)26(24,25)19-17-12-15(5-6-18(17)22-23-19)21-14-7-9-20-10-8-14/h2-6,11-12,14,20-21H,7-10H2,1H3,(H,22,23)
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0.800n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330507
PNG
(5-(4-Methylpiperazin-1-yl)-3-(m-tolylsulfonyl)-1H-...)
Show SMILES CN1CCN(CC1)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc(C)c1
Show InChI InChI=1S/C19H22N4O2S/c1-14-4-3-5-16(12-14)26(24,25)19-17-13-15(6-7-18(17)20-21-19)23-10-8-22(2)9-11-23/h3-7,12-13H,8-11H2,1-2H3,(H,20,21)
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0.900n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334733
PNG
(3-(4-Isopropylphenylsulfonyl)-N-(piperidin-4-yl)-1...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Show InChI InChI=1S/C21H26N4O2S/c1-14(2)15-3-6-18(7-4-15)28(26,27)21-19-13-17(5-8-20(19)24-25-21)23-16-9-11-22-12-10-16/h3-8,13-14,16,22-23H,9-12H2,1-2H3,(H,24,25)
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1n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334732
PNG
(3-(3-Chlorophenylsulfonyl)-N-(piperidin-4-yl)-1H-i...)
Show SMILES Clc1cccc(c1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Show InChI InChI=1S/C18H19ClN4O2S/c19-12-2-1-3-15(10-12)26(24,25)18-16-11-14(4-5-17(16)22-23-18)21-13-6-8-20-9-7-13/h1-5,10-11,13,20-21H,6-9H2,(H,22,23)
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1n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330538
PNG
(3-(3-Chlorophenylsulfonyl)-5-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C18H19ClN4O2S/c1-22-7-9-23(10-8-22)14-5-6-17-16(12-14)18(21-20-17)26(24,25)15-4-2-3-13(19)11-15/h2-6,11-12H,7-10H2,1H3,(H,20,21)
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1n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50085044
PNG
((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccccc1
Show InChI InChI=1S/C34H30N2O5/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)20-21-40-27-18-16-24(17-19-27)22-31(34(38)39)35-30-15-9-8-14-28(30)32(37)25-10-4-2-5-11-25/h2-19,31,35H,20-22H2,1H3,(H,38,39)/t31-/m0/s1
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1.10n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to human Peroxisome proliferator activated receptor gamma using scintillation proximity assay


Bioorg Med Chem Lett 11: 3111-3 (2001)


BindingDB Entry DOI: 10.7270/Q2B27TKM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330512
PNG
(3-(Naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1H-...)
Show SMILES O=S(=O)(c1n[nH]c2ccc(cc12)N1CCNCC1)c1cccc2ccccc12
Show InChI InChI=1S/C21H20N4O2S/c26-28(27,20-7-3-5-15-4-1-2-6-17(15)20)21-18-14-16(8-9-19(18)23-24-21)25-12-10-22-11-13-25/h1-9,14,22H,10-13H2,(H,23,24)
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1.10n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330505
PNG
(3-(3-Methoxyphenylsulfonyl)-5-(4-methylpiperazin-1...)
Show SMILES COc1cccc(c1)S(=O)(=O)c1n[nH]c2ccc(cc12)N1CCN(C)CC1
Show InChI InChI=1S/C19H22N4O3S/c1-22-8-10-23(11-9-22)14-6-7-18-17(12-14)19(21-20-18)27(24,25)16-5-3-4-15(13-16)26-2/h3-7,12-13H,8-11H2,1-2H3,(H,20,21)
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1.10n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334725
PNG
(CHEMBL1642866 | N-(3-(Naphthalen-1-ylsulfonyl)-1H-...)
Show SMILES O=C(Nc1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12)C1CCNCC1
Show InChI InChI=1S/C23H22N4O3S/c28-22(16-10-12-24-13-11-16)25-17-8-9-20-19(14-17)23(27-26-20)31(29,30)21-7-3-5-15-4-1-2-6-18(15)21/h1-9,14,16,24H,10-13H2,(H,25,28)(H,26,27)
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1.10n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM28575
PNG
(1-sulfonylindazole, 6d | 3-(methylamino)-N-[1-(nap...)
Show SMILES CNCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C21H20N4O3S/c1-22-12-11-21(26)24-17-10-9-16-14-23-25(19(16)13-17)29(27,28)20-8-4-6-15-5-2-3-7-18(15)20/h2-10,13-14,22H,11-12H2,1H3,(H,24,26)
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1.20 -50.4n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM28580
PNG
(1-sulfonylindazole, 7b | N-[1-(naphthalene-1-sulfo...)
Show SMILES O=C(Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12)C1CCCNC1
Show InChI InChI=1S/C23H22N4O3S/c28-23(18-7-4-12-24-14-18)26-19-11-10-17-15-25-27(21(17)13-19)31(29,30)22-9-3-6-16-5-1-2-8-20(16)22/h1-3,5-6,8-11,13,15,18,24H,4,7,12,14H2,(H,26,28)
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1.30 -50.2n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM28583
PNG
(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)
Show SMILES COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCNCC1
Show InChI InChI=1S/C20H22ClN3O3S2/c1-13-16-11-14(21)3-6-19(16)28-20(13)29(25,26)23-15-4-5-18(27-2)17(12-15)24-9-7-22-8-10-24/h3-6,11-12,22-23H,7-10H2,1-2H3
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1.30n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5HT6 receptor expressed in HeLa cells


Bioorg Med Chem Lett 19: 3214-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.108
BindingDB Entry DOI: 10.7270/Q2377927
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334747
PNG
(CHEMBL1642849 | N1-(3-(Naphthalen-1-ylsulfonyl)-1H...)
Show SMILES CC(N)CNc1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C20H20N4O2S/c1-13(21)12-22-15-9-10-18-17(11-15)20(24-23-18)27(25,26)19-8-4-6-14-5-2-3-7-16(14)19/h2-11,13,22H,12,21H2,1H3,(H,23,24)
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1.40n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330523
PNG
(1-isobutyl-5-(4-methylpiperazin-1-yl)-3-(naphthale...)
Show SMILES CC(C)Cn1nc(c2cc(ccc12)N1CCN(C)CC1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C26H30N4O2S/c1-19(2)18-30-24-12-11-21(29-15-13-28(3)14-16-29)17-23(24)26(27-30)33(31,32)25-10-6-8-20-7-4-5-9-22(20)25/h4-12,17,19H,13-16,18H2,1-3H3
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1.40n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334720
PNG
(3-Amino-N-[3-(naphthalen-1-sulfonyl)-1H-indazol-5-...)
Show SMILES NCCC(=O)Nc1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C20H18N4O3S/c21-11-10-19(25)22-14-8-9-17-16(12-14)20(24-23-17)28(26,27)18-7-3-5-13-4-1-2-6-15(13)18/h1-9,12H,10-11,21H2,(H,22,25)(H,23,24)
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1.5n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334757
PNG
(CHEMBL1642887 | N-(Piperidin-4-yl)-3-(4-(trifluoro...)
Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Show InChI InChI=1S/C19H19F3N4O2S/c20-19(21,22)12-1-4-15(5-2-12)29(27,28)18-16-11-14(3-6-17(16)25-26-18)24-13-7-9-23-10-8-13/h1-6,11,13,23-24H,7-10H2,(H,25,26)
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1.5n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330516
PNG
(1-methyl-3-(naphthalen-1-ylsulfonyl)-5-(piperazin-...)
Show SMILES Cn1nc(c2cc(ccc12)N1CCNCC1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O2S/c1-25-20-10-9-17(26-13-11-23-12-14-26)15-19(20)22(24-25)29(27,28)21-8-4-6-16-5-2-3-7-18(16)21/h2-10,15,23H,11-14H2,1H3
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1.60n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330511
PNG
(5-(4-Methylpiperazin-1-yl)-3-(1-naphthalenesulfony...)
Show SMILES CN1CCN(CC1)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O2S/c1-25-11-13-26(14-12-25)17-9-10-20-19(15-17)22(24-23-20)29(27,28)21-8-4-6-16-5-2-3-7-18(16)21/h2-10,15H,11-14H2,1H3,(H,23,24)
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1.60n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334716
PNG
(3-(Naphthalen-1-ylsulfonyl)-N-(piperidin-5-yl)-1H-...)
Show SMILES O=S(=O)(c1n[nH]c2ccc(NC3CCCNC3)cc12)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O2S/c27-29(28,21-9-3-6-15-5-1-2-8-18(15)21)22-19-13-16(10-11-20(19)25-26-22)24-17-7-4-12-23-14-17/h1-3,5-6,8-11,13,17,23-24H,4,7,12,14H2,(H,25,26)
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1.70n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330515
PNG
(1-methyl-5-(4-methylpiperazin-1-yl)-3-(naphthalen-...)
Show SMILES CN1CCN(CC1)c1ccc2n(C)nc(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N4O2S/c1-25-12-14-27(15-13-25)18-10-11-21-20(16-18)23(24-26(21)2)30(28,29)22-9-5-7-17-6-3-4-8-19(17)22/h3-11,16H,12-15H2,1-2H3
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1.70n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330535
PNG
(3-(3-Fluorophenylsulfonyl)-5-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C18H19FN4O2S/c1-22-7-9-23(10-8-22)14-5-6-17-16(12-14)18(21-20-17)26(24,25)15-4-2-3-13(19)11-15/h2-6,11-12H,7-10H2,1H3,(H,20,21)
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1.70n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330517
PNG
(1-ethyl-5-(4-methylpiperazin-1-yl)-3-(naphthalen-1...)
Show SMILES CCn1nc(c2cc(ccc12)N1CCN(C)CC1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C24H26N4O2S/c1-3-28-22-12-11-19(27-15-13-26(2)14-16-27)17-21(22)24(25-28)31(29,30)23-10-6-8-18-7-4-5-9-20(18)23/h4-12,17H,3,13-16H2,1-2H3
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1.70n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330521
PNG
(1-isopropyl-5-(4-methylpiperazin-1-yl)-3-(naphthal...)
Show SMILES CC(C)n1nc(c2cc(ccc12)N1CCN(C)CC1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C25H28N4O2S/c1-18(2)29-23-12-11-20(28-15-13-27(3)14-16-28)17-22(23)25(26-29)32(30,31)24-10-6-8-19-7-4-5-9-21(19)24/h4-12,17-18H,13-16H2,1-3H3
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1.80n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM28576
PNG
(1-sulfonylindazole, 6e | 3-(dimethylamino)-N-[1-(n...)
Show SMILES CN(C)CCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O3S/c1-25(2)13-12-22(27)24-18-11-10-17-15-23-26(20(17)14-18)30(28,29)21-9-5-7-16-6-3-4-8-19(16)21/h3-11,14-15H,12-13H2,1-2H3,(H,24,27)
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1.80 -49.4n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330519
PNG
(5-(4-methylpiperazin-1-yl)-3-(naphthalen-1-ylsulfo...)
Show SMILES CCCn1nc(c2cc(ccc12)N1CCN(C)CC1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C25H28N4O2S/c1-3-13-29-23-12-11-20(28-16-14-27(2)15-17-28)18-22(23)25(26-29)32(30,31)24-10-6-8-19-7-4-5-9-21(19)24/h4-12,18H,3,13-17H2,1-2H3
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1.80n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330518
PNG
(1-ethyl-3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1...)
Show SMILES CCn1nc(c2cc(ccc12)N1CCNCC1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N4O2S/c1-2-27-21-11-10-18(26-14-12-24-13-15-26)16-20(21)23(25-27)30(28,29)22-9-5-7-17-6-3-4-8-19(17)22/h3-11,16,24H,2,12-15H2,1H3
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1.90n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330533
PNG
(5-(4-methylpiperazin-1-yl)-3-(phenylsulfonyl)-1H-i...)
Show SMILES CN1CCN(CC1)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H20N4O2S/c1-21-9-11-22(12-10-21)14-7-8-17-16(13-14)18(20-19-17)25(23,24)15-5-3-2-4-6-15/h2-8,13H,9-12H2,1H3,(H,19,20)
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1.90n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330525
PNG
(1-benzyl-5-(4-methylpiperazin-1-yl)-3-(naphthalen-...)
Show SMILES CN1CCN(CC1)c1ccc2n(Cc3ccccc3)nc(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C29H28N4O2S/c1-31-16-18-32(19-17-31)24-14-15-27-26(20-24)29(30-33(27)21-22-8-3-2-4-9-22)36(34,35)28-13-7-11-23-10-5-6-12-25(23)28/h2-15,20H,16-19,21H2,1H3
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2n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM28577
PNG
(1-sulfonylindazole, 6f | 3-(diethylamino)-N-[1-(na...)
Show SMILES CCN(CC)CCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C24H26N4O3S/c1-3-27(4-2)15-14-24(29)26-20-13-12-19-17-25-28(22(19)16-20)32(30,31)23-11-7-9-18-8-5-6-10-21(18)23/h5-13,16-17H,3-4,14-15H2,1-2H3,(H,26,29)
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2.10 -49.0n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330520
PNG
(3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1-p...)
Show SMILES CCCn1nc(c2cc(ccc12)N1CCNCC1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C24H26N4O2S/c1-2-14-28-22-11-10-19(27-15-12-25-13-16-27)17-21(22)24(26-28)31(29,30)23-9-5-7-18-6-3-4-8-20(18)23/h3-11,17,25H,2,12-16H2,1H3
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2.20n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM28579
PNG
(1-sulfonylindazole, 7a | N-[1-(naphthalene-1-sulfo...)
Show SMILES O=C(Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12)C1CCNCC1
Show InChI InChI=1S/C23H22N4O3S/c28-23(17-10-12-24-13-11-17)26-19-9-8-18-15-25-27(21(18)14-19)31(29,30)22-7-3-5-16-4-1-2-6-20(16)22/h1-9,14-15,17,24H,10-13H2,(H,26,28)
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2.30 -48.8n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334756
PNG
(3-(4-Chlorophenylsulfonyl)-N-(piperidin-4-yl)-1H-i...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Show InChI InChI=1S/C18H19ClN4O2S/c19-12-1-4-15(5-2-12)26(24,25)18-16-11-14(3-6-17(16)22-23-18)21-13-7-9-20-10-8-13/h1-6,11,13,20-21H,7-10H2,(H,22,23)
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2.30n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM34141
PNG
(CHEMBL76237 | MS-245)
Show SMILES COc1ccc2n(cc(CCN(C)C)c2c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H22N2O3S/c1-20(2)12-11-15-14-21(19-10-9-16(24-3)13-18(15)19)25(22,23)17-7-5-4-6-8-17/h4-10,13-14H,11-12H2,1-3H3
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2.30n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5HT6 receptor expressed in HeLa cells


Bioorg Med Chem Lett 19: 3214-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.108
BindingDB Entry DOI: 10.7270/Q2377927
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330510
PNG
(3-(2,6-Dichlorophenylsulfonyl)-5-(4-methylpiperazi...)
Show SMILES CN1CCN(CC1)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C18H18Cl2N4O2S/c1-23-7-9-24(10-8-23)12-5-6-16-13(11-12)18(22-21-16)27(25,26)17-14(19)3-2-4-15(17)20/h2-6,11H,7-10H2,1H3,(H,21,22)
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2.60n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334751
PNG
(3-(Naphthalen-1-ylsulfonyl)-N-(piperidin-4-yl)-1H-...)
Show SMILES O=S(=O)(c1n[nH]c2cccc(NC3CCNCC3)c12)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O2S/c27-29(28,20-10-3-6-15-5-1-2-7-17(15)20)22-21-18(8-4-9-19(21)25-26-22)24-16-11-13-23-14-12-16/h1-10,16,23-24H,11-14H2,(H,25,26)
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2.80n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330514
PNG
(1-ethyl-3-(phenylsulfonyl)-5-(piperazin-1-yl)-1H-i...)
Show SMILES CCn1nc(c2cc(ccc12)N1CCNCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H22N4O2S/c1-2-23-18-9-8-15(22-12-10-20-11-13-22)14-17(18)19(21-23)26(24,25)16-6-4-3-5-7-16/h3-9,14,20H,2,10-13H2,1H3
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2.90n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334727
PNG
(CHEMBL1642878 | N-[2-(Dimethylamino)ethyl]-3-(1-na...)
Show SMILES CN(C)CCNC(=O)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O3S/c1-26(2)13-12-23-21(27)16-10-11-19-18(14-16)22(25-24-19)30(28,29)20-9-5-7-15-6-3-4-8-17(15)20/h3-11,14H,12-13H2,1-2H3,(H,23,27)(H,24,25)
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2.90n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330522
PNG
(1-isopropyl-3-(naphthalen-1-ylsulfonyl)-5-(piperaz...)
Show SMILES CC(C)n1nc(c2cc(ccc12)N1CCNCC1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C24H26N4O2S/c1-17(2)28-22-11-10-19(27-14-12-25-13-15-27)16-21(22)24(26-28)31(29,30)23-9-5-7-18-6-3-4-8-20(18)23/h3-11,16-17,25H,12-15H2,1-2H3
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2.90n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334752
PNG
(3-(Phenylsulfonyl)-N-(piperidin-4-yl)-1H-indazol-5...)
Show SMILES O=S(=O)(c1n[nH]c2ccc(NC3CCNCC3)cc12)c1ccccc1
Show InChI InChI=1S/C18H20N4O2S/c23-25(24,15-4-2-1-3-5-15)18-16-12-14(6-7-17(16)21-22-18)20-13-8-10-19-11-9-13/h1-7,12-13,19-20H,8-11H2,(H,21,22)
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3.10n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50277017
PNG
(4-(naphthalen-1-ylsulfonyl)-2-(piperazin-1-yl)benz...)
Show SMILES O=S(=O)(c1cccc2oc(nc12)N1CCNCC1)c1cccc2ccccc12
Show InChI InChI=1S/C21H19N3O3S/c25-28(26,18-9-3-6-15-5-1-2-7-16(15)18)19-10-4-8-17-20(19)23-21(27-17)24-13-11-22-12-14-24/h1-10,22H,11-14H2
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3.10n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


Bioorg Med Chem Lett 19: 1115-7 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.107
BindingDB Entry DOI: 10.7270/Q2X066WD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330527
PNG
(1-methyl-3-(phenylsulfonyl)-5-(piperazin-1-yl)-1H-...)
Show SMILES Cn1nc(c2cc(ccc12)N1CCNCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H20N4O2S/c1-21-17-8-7-14(22-11-9-19-10-12-22)13-16(17)18(20-21)25(23,24)15-5-3-2-4-6-15/h2-8,13,19H,9-12H2,1H3
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3.20n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334739
PNG
(3-Amino-N-(3-(naphthalen-1-ylsulfonyl)-1H-indazol-...)
Show SMILES NCCC(=O)Nc1cccc2c(n[nH]c12)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C20H18N4O3S/c21-12-11-18(25)22-16-9-4-8-15-19(16)23-24-20(15)28(26,27)17-10-3-6-13-5-1-2-7-14(13)17/h1-10H,11-12,21H2,(H,22,25)(H,23,24)
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3.40n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50334718
PNG
(3-(Naphthalen-1-ylsulfonyl)-N-(piperidin-4-ylmethy...)
Show SMILES O=S(=O)(c1n[nH]c2ccc(NCC3CCNCC3)cc12)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N4O2S/c28-30(29,22-7-3-5-17-4-1-2-6-19(17)22)23-20-14-18(8-9-21(20)26-27-23)25-15-16-10-12-24-13-11-16/h1-9,14,16,24-25H,10-13,15H2,(H,26,27)
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3.5n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50085046
PNG
(2-((S)-1-carboxy-2-{4-[2-(5-methyl-2-phenyl-oxazol...)
Show SMILES COC(=O)c1ccccc1N[C@@H](Cc1ccc(OCCc2nc(oc2C)-c2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C29H28N2O6/c1-19-24(31-27(37-19)21-8-4-3-5-9-21)16-17-36-22-14-12-20(13-15-22)18-26(28(32)33)30-25-11-7-6-10-23(25)29(34)35-2/h3-15,26,30H,16-18H2,1-2H3,(H,32,33)/t26-/m0/s1
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3.70n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to human Peroxisome proliferator activated receptor gamma using scintillation proximity assay


Bioorg Med Chem Lett 11: 3111-3 (2001)


BindingDB Entry DOI: 10.7270/Q2B27TKM
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50345980
PNG
(3-(1-methylpiperidin-4-yl)-5-(naphthalen-1-ylsulfo...)
Show SMILES CN1CCC(CC1)c1n[nH]c2ccc(cc12)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C23H23N3O2S/c1-26-13-11-17(12-14-26)23-20-15-18(9-10-21(20)24-25-23)29(27,28)22-8-4-6-16-5-2-3-7-19(16)22/h2-10,15,17H,11-14H2,1H3,(H,24,25)
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3.80n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5HT6 receptor expressed in HeLa cells


Bioorg Med Chem Lett 19: 3214-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.108
BindingDB Entry DOI: 10.7270/Q2377927
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50330537
PNG
(3-(2-Chlorophenylsulfonyl)-5-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1ccccc1Cl
Show InChI InChI=1S/C18H19ClN4O2S/c1-22-8-10-23(11-9-22)13-6-7-16-14(12-13)18(21-20-16)26(24,25)17-5-3-2-4-15(17)19/h2-7,12H,8-11H2,1H3,(H,20,21)
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4n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells


J Med Chem 53: 7639-46 (2010)


Article DOI: 10.1021/jm1007825
BindingDB Entry DOI: 10.7270/Q2GQ6XZ6
More data for this
Ligand-Target Pair
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