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Compile Data Set for Download or QSAR

Found 190 hits with Last Name = 'long' and Initial = 'jz'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342116
PNG
((S)-(1,3,4-oxadiazol-2-yl)(6-phenoxy-1,2,3,4-tetra...)
Show SMILES O=C([C@H]1CCc2cc(Oc3ccccc3)ccc2C1)c1nnco1 |r|
Show InChI InChI=1S/C19H16N2O3/c22-18(19-21-20-12-23-19)15-7-6-14-11-17(9-8-13(14)10-15)24-16-4-2-1-3-5-16/h1-5,8-9,11-12,15H,6-7,10H2/t15-/m0/s1
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0.5n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342118
PNG
((S)-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(...)
Show SMILES O=C([C@H]1CCc2cc(Oc3ccccc3)ccc2C1)c1nnc(o1)-c1ccccn1 |r|
Show InChI InChI=1S/C24H19N3O3/c28-22(24-27-26-23(30-24)21-8-4-5-13-25-21)18-10-9-17-15-20(12-11-16(17)14-18)29-19-6-2-1-3-7-19/h1-8,11-13,15,18H,9-10,14H2/t18-/m0/s1
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1n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342064
PNG
((S)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalene-2-c...)
Show SMILES O=C([C@H]1CCc2cc(Oc3ccccc3)ccc2C1)c1ncc(o1)C#N |r|
Show InChI InChI=1S/C21H16N2O3/c22-12-19-13-23-21(26-19)20(24)16-7-6-15-11-18(9-8-14(15)10-16)25-17-4-2-1-3-5-17/h1-5,8-9,11,13,16H,6-7,10H2/t16-/m0/s1
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1.30n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342123
PNG
((R)-(1,3,4-oxadiazol-2-yl)(6-phenoxy-1,2,3,4-tetra...)
Show SMILES O=C([C@@H]1CCc2cc(Oc3ccccc3)ccc2C1)c1nnco1 |r|
Show InChI InChI=1S/C19H16N2O3/c22-18(19-21-20-12-23-19)15-7-6-14-11-17(9-8-13(14)10-15)24-16-4-2-1-3-5-16/h1-5,8-9,11-12,15H,6-7,10H2/t15-/m1/s1
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1.40n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342104
PNG
((S)-(5-(benzyloxy)-2,3-dihydro-1H-inden-2-yl)(5-(p...)
Show SMILES O=C([C@H]1Cc2ccc(OCc3ccccc3)cc2C1)c1ncc(o1)-c1ccccn1 |r|
Show InChI InChI=1S/C25H20N2O3/c28-24(25-27-15-23(30-25)22-8-4-5-11-26-22)20-12-18-9-10-21(14-19(18)13-20)29-16-17-6-2-1-3-7-17/h1-11,14-15,20H,12-13,16H2/t20-/m0/s1
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1.40n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342117
PNG
((S)-methyl 5-(6-phenoxy-1,2,3,4-tetrahydronaphthal...)
Show SMILES COC(=O)c1nnc(o1)C(=O)[C@H]1CCc2cc(Oc3ccccc3)ccc2C1 |r|
Show InChI InChI=1S/C21H18N2O5/c1-26-21(25)20-23-22-19(28-20)18(24)15-8-7-14-12-17(10-9-13(14)11-15)27-16-5-3-2-4-6-16/h2-6,9-10,12,15H,7-8,11H2,1H3/t15-/m0/s1
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1.5n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342124
PNG
((R)-methyl 5-(6-phenoxy-1,2,3,4-tetrahydronaphthal...)
Show SMILES COC(=O)c1nnc(o1)C(=O)[C@@H]1CCc2cc(Oc3ccccc3)ccc2C1 |r|
Show InChI InChI=1S/C21H18N2O5/c1-26-21(25)20-23-22-19(28-20)18(24)15-8-7-14-12-17(10-9-13(14)11-15)27-16-5-3-2-4-6-16/h2-6,9-10,12,15H,7-8,11H2,1H3/t15-/m1/s1
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1.60n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342096
PNG
((S)-(5-phenyl-2,3-dihydro-1H-inden-2-yl)(5-(pyridi...)
Show SMILES O=C([C@H]1Cc2ccc(cc2C1)-c1ccccc1)c1ncc(o1)-c1ccccn1 |r|
Show InChI InChI=1S/C24H18N2O2/c27-23(24-26-15-22(28-24)21-8-4-5-11-25-21)20-13-18-10-9-17(12-19(18)14-20)16-6-2-1-3-7-16/h1-12,15,20H,13-14H2/t20-/m0/s1
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1.90n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342100
PNG
((S)-(5-phenoxy-2,3-dihydro-1H-inden-2-yl)(5-(pyrid...)
Show SMILES O=C([C@H]1Cc2ccc(Oc3ccccc3)cc2C1)c1ncc(o1)-c1ccccn1 |r|
Show InChI InChI=1S/C24H18N2O3/c27-23(24-26-15-22(29-24)21-8-4-5-11-25-21)18-12-16-9-10-20(14-17(16)13-18)28-19-6-2-1-3-7-19/h1-11,14-15,18H,12-13H2/t18-/m0/s1
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2.10n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342062
PNG
((S)-oxazol-2-yl(6-phenoxy-1,2,3,4-tetrahydronaphth...)
Show SMILES O=C([C@H]1CCc2cc(Oc3ccccc3)ccc2C1)c1ncco1 |r|
Show InChI InChI=1S/C20H17NO3/c22-19(20-21-10-11-23-20)16-7-6-15-13-18(9-8-14(15)12-16)24-17-4-2-1-3-5-17/h1-5,8-11,13,16H,6-7,12H2/t16-/m0/s1
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2.20n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342066
PNG
((S)-methyl 6-(2-(6-phenoxy-1,2,3,4-tetrahydronapht...)
Show SMILES COC(=O)c1cccc(n1)-c1cnc(o1)C(=O)[C@H]1CCc2cc(Oc3ccccc3)ccc2C1 |r|
Show InChI InChI=1S/C27H22N2O5/c1-32-27(31)23-9-5-8-22(29-23)24-16-28-26(34-24)25(30)19-11-10-18-15-21(13-12-17(18)14-19)33-20-6-3-2-4-7-20/h2-9,12-13,15-16,19H,10-11,14H2,1H3/t19-/m0/s1
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2.20n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342069
PNG
((S)-methyl 2-(6-(benzyloxy)-1,2,3,4-tetrahydronaph...)
Show SMILES COC(=O)c1cnc(o1)C(=O)[C@H]1CCc2cc(OCc3ccccc3)ccc2C1 |r|
Show InChI InChI=1S/C23H21NO5/c1-27-23(26)20-13-24-22(29-20)21(25)18-8-7-17-12-19(10-9-16(17)11-18)28-14-15-5-3-2-4-6-15/h2-6,9-10,12-13,18H,7-8,11,14H2,1H3/t18-/m0/s1
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2.90n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342070
PNG
((S)-2-(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalene...)
Show SMILES O=C([C@H]1CCc2cc(OCc3ccccc3)ccc2C1)c1ncc(o1)C#N |r|
Show InChI InChI=1S/C22H18N2O3/c23-12-20-13-24-22(27-20)21(25)18-7-6-17-11-19(9-8-16(17)10-18)26-14-15-4-2-1-3-5-15/h1-5,8-9,11,13,18H,6-7,10,14H2/t18-/m0/s1
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3.20n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342071
PNG
((S)-(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-...)
Show SMILES O=C([C@H]1CCc2cc(OCc3ccccc3)ccc2C1)c1ncc(o1)-c1ccccn1 |r|
Show InChI InChI=1S/C26H22N2O3/c29-25(26-28-16-24(31-26)23-8-4-5-13-27-23)21-10-9-20-15-22(12-11-19(20)14-21)30-17-18-6-2-1-3-7-18/h1-8,11-13,15-16,21H,9-10,14,17H2/t21-/m0/s1
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3.20n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342058
PNG
((S)-2-(6-phenyl-1,2,3,4-tetrahydronaphthalene-2-ca...)
Show SMILES O=C([C@H]1CCc2cc(ccc2C1)-c1ccccc1)c1ncc(o1)C#N |r|
Show InChI InChI=1S/C21H16N2O2/c22-12-19-13-23-21(25-19)20(24)18-9-8-16-10-15(6-7-17(16)11-18)14-4-2-1-3-5-14/h1-7,10,13,18H,8-9,11H2/t18-/m0/s1
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3.40n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342093
PNG
((S)-(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-...)
Show SMILES Ic1cnc(o1)C(=O)[C@H]1CCc2cc(OCc3ccccc3)ccc2C1 |r|
Show InChI InChI=1S/C21H18INO3/c22-19-12-23-21(26-19)20(24)17-7-6-16-11-18(9-8-15(16)10-17)25-13-14-4-2-1-3-5-14/h1-5,8-9,11-12,17H,6-7,10,13H2/t17-/m0/s1
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4.10n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50342065
PNG
((S)-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(...)
Show SMILES O=C([C@H]1CCc2cc(Oc3ccccc3)ccc2C1)c1ncc(o1)-c1ccccn1 |r|
Show InChI InChI=1S/C25H20N2O3/c28-24(25-27-16-23(30-25)22-8-4-5-13-26-22)19-10-9-18-15-21(12-11-17(18)14-19)29-20-6-2-1-3-7-20/h1-8,11-13,15-16,19H,9-10,14H2/t19-/m0/s1
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4.40n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342065
PNG
((S)-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(...)
Show SMILES O=C([C@H]1CCc2cc(Oc3ccccc3)ccc2C1)c1ncc(o1)-c1ccccn1 |r|
Show InChI InChI=1S/C25H20N2O3/c28-24(25-27-16-23(30-25)22-8-4-5-13-26-22)19-10-9-18-15-21(12-11-17(18)14-19)29-20-6-2-1-3-7-20/h1-8,11-13,15-16,19H,9-10,14H2/t19-/m0/s1
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4.40n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342063
PNG
((S)-methyl 2-(6-phenoxy-1,2,3,4-tetrahydronaphthal...)
Show SMILES COC(=O)c1cnc(o1)C(=O)[C@H]1CCc2cc(Oc3ccccc3)ccc2C1 |r|
Show InChI InChI=1S/C22H19NO5/c1-26-22(25)19-13-23-21(28-19)20(24)16-8-7-15-12-18(10-9-14(15)11-16)27-17-5-3-2-4-6-17/h2-6,9-10,12-13,16H,7-8,11H2,1H3/t16-/m0/s1
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5.40n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342105
PNG
((S)-methyl 6-(2-(5-(benzyloxy)-2,3-dihydro-1H-inde...)
Show SMILES COC(=O)c1cccc(n1)-c1cnc(o1)C(=O)[C@H]1Cc2ccc(OCc3ccccc3)cc2C1 |r|
Show InChI InChI=1S/C27H22N2O5/c1-32-27(31)23-9-5-8-22(29-23)24-15-28-26(34-24)25(30)20-12-18-10-11-21(14-19(18)13-20)33-16-17-6-3-2-4-7-17/h2-11,14-15,20H,12-13,16H2,1H3/t20-/m0/s1
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5.80n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342068
PNG
((S)-(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-...)
Show SMILES O=C([C@H]1CCc2cc(OCc3ccccc3)ccc2C1)c1ncco1 |r|
Show InChI InChI=1S/C21H19NO3/c23-20(21-22-10-11-24-21)18-7-6-17-13-19(9-8-16(17)12-18)25-14-15-4-2-1-3-5-15/h1-5,8-11,13,18H,6-7,12,14H2/t18-/m0/s1
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6.10n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342097
PNG
(CHEMBL1765863 | rac-Methyl 6-[2-(5-Phenylindane-2-...)
Show SMILES COC(=O)c1cccc(n1)-c1cnc(o1)C(=O)C1Cc2ccc(cc2C1)-c1ccccc1
Show InChI InChI=1S/C26H20N2O4/c1-31-26(30)22-9-5-8-21(28-22)23-15-27-25(32-23)24(29)20-13-18-11-10-17(12-19(18)14-20)16-6-3-2-4-7-16/h2-12,15,20H,13-14H2,1H3
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6.20n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342125
PNG
((R)-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(...)
Show SMILES O=C([C@@H]1CCc2cc(Oc3ccccc3)ccc2C1)c1nnc(o1)-c1ccccn1 |r|
Show InChI InChI=1S/C24H19N3O3/c28-22(24-27-26-23(30-24)21-8-4-5-13-25-21)18-10-9-17-15-20(12-11-16(17)14-18)29-19-6-2-1-3-7-19/h1-8,11-13,15,18H,9-10,14H2/t18-/m1/s1
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6.30n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342059
PNG
((S)-(6-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)(5...)
Show SMILES O=C([C@H]1CCc2cc(ccc2C1)-c1ccccc1)c1ncc(o1)-c1ccccn1 |r|
Show InChI InChI=1S/C25H20N2O2/c28-24(25-27-16-23(29-25)22-8-4-5-13-26-22)21-12-11-19-14-18(9-10-20(19)15-21)17-6-2-1-3-7-17/h1-10,13-14,16,21H,11-12,15H2/t21-/m0/s1
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7.20n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342092
PNG
((+/-)-(6-(Benzyloxy)-1,2,3,4-tetrahydronaphthalen-...)
Show SMILES Ic1cnc(o1)C(=O)C1CCc2cc(OCc3ccccc3)ccc2C1
Show InChI InChI=1S/C21H18INO3/c22-19-12-23-21(26-19)20(24)17-7-6-16-11-18(9-8-15(16)10-17)25-13-14-4-2-1-3-5-14/h1-5,8-9,11-12,17H,6-7,10,13H2
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8n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342099
PNG
((S)-oxazol-2-yl(5-phenoxy-2,3-dihydro-1H-inden-2-y...)
Show SMILES O=C([C@H]1Cc2ccc(Oc3ccccc3)cc2C1)c1ncco1 |r|
Show InChI InChI=1S/C19H15NO3/c21-18(19-20-8-9-22-19)15-10-13-6-7-17(12-14(13)11-15)23-16-4-2-1-3-5-16/h1-9,12,15H,10-11H2/t15-/m0/s1
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10n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342072
PNG
((S)-methyl 6-(2-(6-(benzyloxy)-1,2,3,4-tetrahydron...)
Show SMILES COC(=O)c1cccc(n1)-c1cnc(o1)C(=O)[C@H]1CCc2cc(OCc3ccccc3)ccc2C1 |r|
Show InChI InChI=1S/C28H24N2O5/c1-33-28(32)24-9-5-8-23(30-24)25-16-29-27(35-25)26(31)21-11-10-20-15-22(13-12-19(20)14-21)34-17-18-6-3-2-4-7-18/h2-9,12-13,15-16,21H,10-11,14,17H2,1H3/t21-/m0/s1
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18n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342103
PNG
(CHEMBL1765869 | rac-(5-(Benzyloxy)indan-2-yl)(oxaz...)
Show SMILES O=C(C1Cc2ccc(OCc3ccccc3)cc2C1)c1ncco1
Show InChI InChI=1S/C20H17NO3/c22-19(20-21-8-9-23-20)17-10-15-6-7-18(12-16(15)11-17)24-13-14-4-2-1-3-5-14/h1-9,12,17H,10-11,13H2
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>24n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50342067
PNG
((S)-6-(2-(6-phenoxy-1,2,3,4-tetrahydronaphthalene-...)
Show SMILES OC(=O)c1cccc(n1)-c1cnc(o1)C(=O)[C@H]1CCc2cc(Oc3ccccc3)ccc2C1 |r|
Show InChI InChI=1S/C26H20N2O5/c29-24(25-27-15-23(33-25)21-7-4-8-22(28-21)26(30)31)18-10-9-17-14-20(12-11-16(17)13-18)32-19-5-2-1-3-6-19/h1-8,11-12,14-15,18H,9-10,13H2,(H,30,31)/t18-/m0/s1
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25n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342067
PNG
((S)-6-(2-(6-phenoxy-1,2,3,4-tetrahydronaphthalene-...)
Show SMILES OC(=O)c1cccc(n1)-c1cnc(o1)C(=O)[C@H]1CCc2cc(Oc3ccccc3)ccc2C1 |r|
Show InChI InChI=1S/C26H20N2O5/c29-24(25-27-15-23(33-25)21-7-4-8-22(28-21)26(30)31)18-10-9-17-14-20(12-11-16(17)13-18)32-19-5-2-1-3-6-19/h1-8,11-12,14-15,18H,9-10,13H2,(H,30,31)/t18-/m0/s1
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25n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342060
PNG
((S)-methyl 6-(2-(6-phenyl-1,2,3,4-tetrahydronaphth...)
Show SMILES COC(=O)c1cccc(n1)-c1cnc(o1)C(=O)[C@H]1CCc2cc(ccc2C1)-c1ccccc1 |r|
Show InChI InChI=1S/C27H22N2O4/c1-32-27(31)23-9-5-8-22(29-23)24-16-28-26(33-24)25(30)21-13-12-19-14-18(10-11-20(19)15-21)17-6-3-2-4-7-17/h2-11,14,16,21H,12-13,15H2,1H3/t21-/m0/s1
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27n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342095
PNG
((S)-oxazol-2-yl(5-phenyl-2,3-dihydro-1H-inden-2-yl...)
Show SMILES O=C([C@H]1Cc2ccc(cc2C1)-c1ccccc1)c1ncco1 |r|
Show InChI InChI=1S/C19H15NO2/c21-18(19-20-8-9-22-19)17-11-15-7-6-14(10-16(15)12-17)13-4-2-1-3-5-13/h1-10,17H,11-12H2/t17-/m0/s1
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27n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342073
PNG
((S)-6-(2-(6-(benzyloxy)-1,2,3,4-tetrahydronaphthal...)
Show SMILES OC(=O)c1cccc(n1)-c1cnc(o1)C(=O)[C@H]1CCc2cc(OCc3ccccc3)ccc2C1 |r|
Show InChI InChI=1S/C27H22N2O5/c30-25(26-28-15-24(34-26)22-7-4-8-23(29-22)27(31)32)20-10-9-19-14-21(12-11-18(19)13-20)33-16-17-5-2-1-3-6-17/h1-8,11-12,14-15,20H,9-10,13,16H2,(H,31,32)/t20-/m0/s1
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34n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342061
PNG
((S)-6-(2-(6-phenyl-1,2,3,4-tetrahydronaphthalene-2...)
Show SMILES OC(=O)c1cccc(n1)-c1cnc(o1)C(=O)[C@H]1CCc2cc(ccc2C1)-c1ccccc1 |r|
Show InChI InChI=1S/C26H20N2O4/c29-24(25-27-15-23(32-25)21-7-4-8-22(28-21)26(30)31)20-12-11-18-13-17(9-10-19(18)14-20)16-5-2-1-3-6-16/h1-10,13,15,20H,11-12,14H2,(H,30,31)/t20-/m0/s1
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39n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342110
PNG
((R)-(5-phenoxy-2,3-dihydro-1H-inden-2-yl)(5-(pyrid...)
Show SMILES O=C([C@@H]1Cc2ccc(Oc3ccccc3)cc2C1)c1ncc(o1)-c1ccccn1 |r|
Show InChI InChI=1S/C24H18N2O3/c27-23(24-26-15-22(29-24)21-8-4-5-11-25-21)18-12-16-9-10-20(14-17(16)13-18)28-19-6-2-1-3-7-19/h1-11,14-15,18H,12-13H2/t18-/m1/s1
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42n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342106
PNG
((S)-6-(2-(5-(benzyloxy)-2,3-dihydro-1H-indene-2-ca...)
Show SMILES OC(=O)c1cccc(n1)-c1cnc(o1)C(=O)[C@H]1Cc2ccc(OCc3ccccc3)cc2C1 |r|
Show InChI InChI=1S/C26H20N2O5/c29-24(25-27-14-23(33-25)21-7-4-8-22(28-21)26(30)31)19-11-17-9-10-20(13-18(17)12-19)32-15-16-5-2-1-3-6-16/h1-10,13-14,19H,11-12,15H2,(H,30,31)/t19-/m0/s1
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51n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342087
PNG
((R)-methyl 2-(6-(benzyloxy)-1,2,3,4-tetrahydronaph...)
Show SMILES COC(=O)c1cnc(o1)C(=O)[C@@H]1CCc2cc(OCc3ccccc3)ccc2C1 |r|
Show InChI InChI=1S/C23H21NO5/c1-27-23(26)20-13-24-22(29-20)21(25)18-8-7-17-12-19(10-9-16(17)11-18)28-14-15-5-3-2-4-6-15/h2-6,9-10,12-13,18H,7-8,11,14H2,1H3/t18-/m1/s1
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53n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342082
PNG
((R)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalene-2-c...)
Show SMILES O=C([C@@H]1CCc2cc(Oc3ccccc3)ccc2C1)c1ncc(o1)C#N |r|
Show InChI InChI=1S/C21H16N2O3/c22-12-19-13-23-21(26-19)20(24)16-7-6-15-11-18(9-8-14(15)10-16)25-17-4-2-1-3-5-17/h1-5,8-9,11,13,16H,6-7,10H2/t16-/m1/s1
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54n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342057
PNG
((S)-methyl 2-(6-phenyl-1,2,3,4-tetrahydronaphthale...)
Show SMILES COC(=O)c1cnc(o1)C(=O)[C@H]1CCc2cc(ccc2C1)-c1ccccc1 |r|
Show InChI InChI=1S/C22H19NO4/c1-26-22(25)19-13-23-21(27-19)20(24)18-10-9-16-11-15(7-8-17(16)12-18)14-5-3-2-4-6-14/h2-8,11,13,18H,9-10,12H2,1H3/t18-/m0/s1
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55n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342056
PNG
((S)-oxazol-2-yl(6-phenyl-1,2,3,4-tetrahydronaphtha...)
Show SMILES O=C([C@H]1CCc2cc(ccc2C1)-c1ccccc1)c1ncco1 |r|
Show InChI InChI=1S/C20H17NO2/c22-19(20-21-10-11-23-20)18-9-8-16-12-15(6-7-17(16)13-18)14-4-2-1-3-5-14/h1-7,10-12,18H,8-9,13H2/t18-/m0/s1
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57n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342098
PNG
(CHEMBL1765864 | rac-6-[2-(5-Phenylindane-2-carbony...)
Show SMILES OC(=O)c1cccc(n1)-c1cnc(o1)C(=O)C1Cc2ccc(cc2C1)-c1ccccc1
Show InChI InChI=1S/C25H18N2O4/c28-23(24-26-14-22(31-24)20-7-4-8-21(27-20)25(29)30)19-12-17-10-9-16(11-18(17)13-19)15-5-2-1-3-6-15/h1-11,14,19H,12-13H2,(H,29,30)
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57n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342081
PNG
((R)-methyl 2-(6-phenoxy-1,2,3,4-tetrahydronaphthal...)
Show SMILES COC(=O)c1cnc(o1)C(=O)[C@@H]1CCc2cc(Oc3ccccc3)ccc2C1 |r|
Show InChI InChI=1S/C22H19NO5/c1-26-22(25)19-13-23-21(28-19)20(24)16-8-7-15-12-18(10-9-14(15)11-16)27-17-5-3-2-4-6-17/h2-6,9-10,12-13,16H,7-8,11H2,1H3/t16-/m1/s1
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59n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342076
PNG
((R)-2-(6-phenyl-1,2,3,4-tetrahydronaphthalene-2-ca...)
Show SMILES O=C([C@@H]1CCc2cc(ccc2C1)-c1ccccc1)c1ncc(o1)C#N |r|
Show InChI InChI=1S/C21H16N2O2/c22-12-19-13-23-21(25-19)20(24)18-9-8-16-10-15(6-7-17(16)11-18)14-4-2-1-3-5-14/h1-7,10,13,18H,8-9,11H2/t18-/m1/s1
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62n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342102
PNG
((S)-6-(2-(5-phenoxy-2,3-dihydro-1H-indene-2-carbon...)
Show SMILES OC(=O)c1cccc(n1)-c1cnc(o1)C(=O)[C@H]1Cc2ccc(Oc3ccccc3)cc2C1 |r|
Show InChI InChI=1S/C25H18N2O5/c28-23(24-26-14-22(32-24)20-7-4-8-21(27-20)25(29)30)17-11-15-9-10-19(13-16(15)12-17)31-18-5-2-1-3-6-18/h1-10,13-14,17H,11-12H2,(H,29,30)/t17-/m0/s1
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71n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342086
PNG
((R)-(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-...)
Show SMILES O=C([C@@H]1CCc2cc(OCc3ccccc3)ccc2C1)c1ncco1 |r|
Show InChI InChI=1S/C21H19NO3/c23-20(21-22-10-11-24-21)18-7-6-17-13-19(9-8-16(17)12-18)25-14-15-4-2-1-3-5-15/h1-5,8-11,13,18H,6-7,12,14H2/t18-/m1/s1
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87n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342101
PNG
((S)-methyl 6-(2-(5-phenoxy-2,3-dihydro-1H-indene-2...)
Show SMILES COC(=O)c1cccc(n1)-c1cnc(o1)C(=O)[C@H]1Cc2ccc(Oc3ccccc3)cc2C1 |r|
Show InChI InChI=1S/C26H20N2O5/c1-31-26(30)22-9-5-8-21(28-22)23-15-27-25(33-23)24(29)18-12-16-10-11-20(14-17(16)13-18)32-19-6-3-2-4-7-19/h2-11,14-15,18H,12-13H2,1H3/t18-/m0/s1
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98n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342113
PNG
((R)-(5-(benzyloxy)-2,3-dihydro-1H-inden-2-yl)(5-(p...)
Show SMILES O=C([C@@H]1Cc2ccc(OCc3ccccc3)cc2C1)c1ncc(o1)-c1ccccn1 |r|
Show InChI InChI=1S/C25H20N2O3/c28-24(25-27-15-23(30-25)22-8-4-5-11-26-22)20-12-18-9-10-21(14-19(18)13-20)29-16-17-6-2-1-3-7-17/h1-11,14-15,20H,12-13,16H2/t20-/m1/s1
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110n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342088
PNG
((R)-2-(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalene...)
Show SMILES O=C([C@@H]1CCc2cc(OCc3ccccc3)ccc2C1)c1ncc(o1)C#N |r|
Show InChI InChI=1S/C22H18N2O3/c23-12-20-13-24-22(27-20)21(25)18-7-6-17-11-19(9-8-16(17)10-18)26-14-15-4-2-1-3-5-15/h1-5,8-9,11,13,18H,6-7,10,14H2/t18-/m1/s1
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120n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342114
PNG
((R)-methyl 6-(2-(5-(benzyloxy)-2,3-dihydro-1H-inde...)
Show SMILES COC(=O)c1cccc(n1)-c1cnc(o1)C(=O)[C@@H]1Cc2ccc(OCc3ccccc3)cc2C1 |r|
Show InChI InChI=1S/C27H22N2O5/c1-32-27(31)23-9-5-8-22(29-23)24-15-28-26(34-24)25(30)20-12-18-10-11-21(14-19(18)13-20)33-16-17-6-3-2-4-7-17/h2-11,14-15,20H,12-13,16H2,1H3/t20-/m1/s1
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130n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50342107
PNG
((R)-oxazol-2-yl(5-phenyl-2,3-dihydro-1H-inden-2-yl...)
Show SMILES O=C([C@@H]1Cc2ccc(cc2C1)-c1ccccc1)c1ncco1 |r|
Show InChI InChI=1S/C19H15NO2/c21-18(19-20-8-9-22-19)17-11-15-7-6-14(10-16(15)12-17)13-4-2-1-3-5-13/h1-10,17H,11-12H2/t17-/m1/s1
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140n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length human FAAH expressed in COS-7 cells assessed as [14C]-labeled oleamide to oleic acid conversion


J Med Chem 54: 2805-22 (2011)


Article DOI: 10.1021/jm101597x
BindingDB Entry DOI: 10.7270/Q2ZK5H08
More data for this
Ligand-Target Pair
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