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Compile Data Set for Download or QSAR

Found 65 hits with Last Name = 'luetje' and Initial = 'cw'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholinergic, Nicotinic Alpha2Beta2


(Xenopus)
BDBM86041
PNG
(NFEP)
Show SMILES Fc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H13FN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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0.00240n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta2


(Xenopus)
BDBM86042
PNG
(NEP)
Show SMILES C1CC2NC1C[C@@H]2c1cccnc1 |r,TLB:7:6:0.1:3|
Show InChI InChI=1S/C11H14N2/c1-2-8(7-12-5-1)10-6-9-3-4-11(10)13-9/h1-2,5,7,9-11,13H,3-4,6H2/t9?,10-,11?/m1/s1
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0.00310n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta2


(Xenopus)
BDBM86041
PNG
(NFEP)
Show SMILES Fc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H13FN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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0.00380n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta2


(Xenopus)
BDBM86040
PNG
(NBEP)
Show SMILES Brc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H13BrN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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0.00400n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha4Beta2


(Xenopus)
BDBM86042
PNG
(NEP)
Show SMILES C1CC2NC1C[C@@H]2c1cccnc1 |r,TLB:7:6:0.1:3|
Show InChI InChI=1S/C11H14N2/c1-2-8(7-12-5-1)10-6-9-3-4-11(10)13-9/h1-2,5,7,9-11,13H,3-4,6H2/t9?,10-,11?/m1/s1
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0.00850n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha4Beta2


(Xenopus)
BDBM86041
PNG
(NFEP)
Show SMILES Fc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H13FN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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0.00920n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha4Beta2


(Xenopus)
BDBM86040
PNG
(NBEP)
Show SMILES Brc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H13BrN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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0.0100n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha2Beta2


(Xenopus)
BDBM86040
PNG
(NBEP)
Show SMILES Brc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H13BrN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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0.0130n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha2Beta2


(Xenopus)
BDBM86042
PNG
(NEP)
Show SMILES C1CC2NC1C[C@@H]2c1cccnc1 |r,TLB:7:6:0.1:3|
Show InChI InChI=1S/C11H14N2/c1-2-8(7-12-5-1)10-6-9-3-4-11(10)13-9/h1-2,5,7,9-11,13H,3-4,6H2/t9?,10-,11?/m1/s1
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0.0280n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha4Beta4


(Xenopus)
BDBM86040
PNG
(NBEP)
Show SMILES Brc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H13BrN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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0.0440n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha2Beta2


(Xenopus)
BDBM86040
PNG
(NBEP)
Show SMILES Brc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H13BrN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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0.0550n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha2Beta2


(Xenopus)
BDBM86045
PNG
(NNEP)
Show SMILES Nc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H15N3/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2,(H2,12,13)/t8?,9-,10?/m1/s1
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0.0620n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta2


(Xenopus)
BDBM86045
PNG
(NNEP)
Show SMILES Nc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H15N3/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2,(H2,12,13)/t8?,9-,10?/m1/s1
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0.0770n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta4x


(Xenopus)
BDBM86040
PNG
(NBEP)
Show SMILES Brc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H13BrN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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0.220n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha4Beta2


(Xenopus)
BDBM86045
PNG
(NNEP)
Show SMILES Nc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H15N3/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2,(H2,12,13)/t8?,9-,10?/m1/s1
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0.350n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha4Beta4


(Xenopus)
BDBM86041
PNG
(NFEP)
Show SMILES Fc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H13FN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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0.480n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha2Beta2


(Xenopus)
BDBM86041
PNG
(NFEP)
Show SMILES Fc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H13FN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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1.20n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta4x


(Xenopus)
BDBM86041
PNG
(NFEP)
Show SMILES Fc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H13FN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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2.10n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha4Beta4


(Xenopus)
BDBM86042
PNG
(NEP)
Show SMILES C1CC2NC1C[C@@H]2c1cccnc1 |r,TLB:7:6:0.1:3|
Show InChI InChI=1S/C11H14N2/c1-2-8(7-12-5-1)10-6-9-3-4-11(10)13-9/h1-2,5,7,9-11,13H,3-4,6H2/t9?,10-,11?/m1/s1
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3.20n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha2Beta2


(Xenopus)
BDBM86042
PNG
(NEP)
Show SMILES C1CC2NC1C[C@@H]2c1cccnc1 |r,TLB:7:6:0.1:3|
Show InChI InChI=1S/C11H14N2/c1-2-8(7-12-5-1)10-6-9-3-4-11(10)13-9/h1-2,5,7,9-11,13H,3-4,6H2/t9?,10-,11?/m1/s1
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3.30n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha2Beta2


(Xenopus)
BDBM86045
PNG
(NNEP)
Show SMILES Nc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H15N3/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2,(H2,12,13)/t8?,9-,10?/m1/s1
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3.5n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha4Beta4


(Xenopus)
BDBM86045
PNG
(NNEP)
Show SMILES Nc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H15N3/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2,(H2,12,13)/t8?,9-,10?/m1/s1
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4.30n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta4x


(Xenopus)
BDBM86045
PNG
(NNEP)
Show SMILES Nc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Show InChI InChI=1S/C11H15N3/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2,(H2,12,13)/t8?,9-,10?/m1/s1
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7.20n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha2Beta2


(Xenopus)
BDBM86044
PNG
(NTEP)
Show SMILES FC(F)(F)S(=O)(=O)Oc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:11:14:17.18:20|
Show InChI InChI=1S/C12H13F3N2O3S/c13-12(14,15)21(18,19)20-11-4-1-7(6-16-11)9-5-8-2-3-10(9)17-8/h1,4,6,8-10,17H,2-3,5H2/t8?,9-,10?/m1/s1
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10n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta4x


(Xenopus)
BDBM86042
PNG
(NEP)
Show SMILES C1CC2NC1C[C@@H]2c1cccnc1 |r,TLB:7:6:0.1:3|
Show InChI InChI=1S/C11H14N2/c1-2-8(7-12-5-1)10-6-9-3-4-11(10)13-9/h1-2,5,7,9-11,13H,3-4,6H2/t9?,10-,11?/m1/s1
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11n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta2


(Xenopus)
BDBM50063218
PNG
((R)-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]...)
Show SMILES Clc1ccc(cn1)[C@H]1CC2CCC1N2 |THB:4:7:13:11.10|
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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14n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha4Beta2


(Xenopus)
BDBM50063218
PNG
((R)-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]...)
Show SMILES Clc1ccc(cn1)[C@H]1CC2CCC1N2 |THB:4:7:13:11.10|
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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30n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50166908
PNG
(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)
Show SMILES C1C2CNCC1c1cc3nccnc3cc21
Show InChI InChI=1S/C13H13N3/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1/h1-2,4-5,8-9,14H,3,6-7H2
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32.5n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assay


J Med Chem 55: 6512-22 (2012)


Article DOI: 10.1021/jm300575y
BindingDB Entry DOI: 10.7270/Q2CV4JV0
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha4Beta4


(Xenopus)
BDBM50063218
PNG
((R)-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]...)
Show SMILES Clc1ccc(cn1)[C@H]1CC2CCC1N2 |THB:4:7:13:11.10|
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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85n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha2Beta2


(Xenopus)
BDBM50063218
PNG
((R)-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]...)
Show SMILES Clc1ccc(cn1)[C@H]1CC2CCC1N2 |THB:4:7:13:11.10|
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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87n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha2Beta2


(Xenopus)
BDBM86043
PNG
(NDMNEP)
Show SMILES CN(C)c1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:6:9:12.13:15|
Show InChI InChI=1S/C13H19N3/c1-16(2)13-6-3-9(8-14-13)11-7-10-4-5-12(11)15-10/h3,6,8,10-12,15H,4-5,7H2,1-2H3/t10?,11-,12?/m1/s1
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100n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha2Beta2


(Xenopus)
BDBM50119631
PNG
(5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridin-2-ol | C...)
Show SMILES O=c1ccc(c[nH]1)[C@H]1CC2CCC1N2 |THB:4:7:13:11.10|
Show InChI InChI=1S/C11H14N2O/c14-11-4-1-7(6-12-11)9-5-8-2-3-10(9)13-8/h1,4,6,8-10,13H,2-3,5H2,(H,12,14)/t8?,9-,10?/m1/s1
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100n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta2


(Xenopus)
BDBM86043
PNG
(NDMNEP)
Show SMILES CN(C)c1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:6:9:12.13:15|
Show InChI InChI=1S/C13H19N3/c1-16(2)13-6-3-9(8-14-13)11-7-10-4-5-12(11)15-10/h3,6,8,10-12,15H,4-5,7H2,1-2H3/t10?,11-,12?/m1/s1
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100n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta2


(Xenopus)
BDBM50119631
PNG
(5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridin-2-ol | C...)
Show SMILES O=c1ccc(c[nH]1)[C@H]1CC2CCC1N2 |THB:4:7:13:11.10|
Show InChI InChI=1S/C11H14N2O/c14-11-4-1-7(6-12-11)9-5-8-2-3-10(9)13-8/h1,4,6,8-10,13H,2-3,5H2,(H,12,14)/t8?,9-,10?/m1/s1
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100n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta2


(Xenopus)
BDBM86044
PNG
(NTEP)
Show SMILES FC(F)(F)S(=O)(=O)Oc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:11:14:17.18:20|
Show InChI InChI=1S/C12H13F3N2O3S/c13-12(14,15)21(18,19)20-11-4-1-7(6-16-11)9-5-8-2-3-10(9)17-8/h1,4,6,8-10,17H,2-3,5H2/t8?,9-,10?/m1/s1
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100n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha4Beta2


(Xenopus)
BDBM86043
PNG
(NDMNEP)
Show SMILES CN(C)c1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:6:9:12.13:15|
Show InChI InChI=1S/C13H19N3/c1-16(2)13-6-3-9(8-14-13)11-7-10-4-5-12(11)15-10/h3,6,8,10-12,15H,4-5,7H2,1-2H3/t10?,11-,12?/m1/s1
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100n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha4Beta2


(Xenopus)
BDBM50119631
PNG
(5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridin-2-ol | C...)
Show SMILES O=c1ccc(c[nH]1)[C@H]1CC2CCC1N2 |THB:4:7:13:11.10|
Show InChI InChI=1S/C11H14N2O/c14-11-4-1-7(6-12-11)9-5-8-2-3-10(9)13-8/h1,4,6,8-10,13H,2-3,5H2,(H,12,14)/t8?,9-,10?/m1/s1
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100n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha4Beta2


(Xenopus)
BDBM86044
PNG
(NTEP)
Show SMILES FC(F)(F)S(=O)(=O)Oc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:11:14:17.18:20|
Show InChI InChI=1S/C12H13F3N2O3S/c13-12(14,15)21(18,19)20-11-4-1-7(6-16-11)9-5-8-2-3-10(9)17-8/h1,4,6,8-10,17H,2-3,5H2/t8?,9-,10?/m1/s1
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100n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta4x


(Xenopus)
BDBM50063218
PNG
((R)-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]...)
Show SMILES Clc1ccc(cn1)[C@H]1CC2CCC1N2 |THB:4:7:13:11.10|
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10?/m1/s1
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300n/an/an/an/an/an/an/an/a



University of Miami

Curated by PDSP Ki Database




J Pharmacol Exp Ther 302: 1246-52 (2002)


Article DOI: 10.1124/jpet.102.035899
BindingDB Entry DOI: 10.7270/Q2HQ3XG3
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50395217
PNG
(CHEMBL2164667 | US9150581, RTI-7527-168)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(cnc1F)C1CC2CCC1N2 |THB:11:16:19.20:22|
Show InChI InChI=1S/C18H18FN3O/c19-17-15(10-1-3-11(4-2-10)18(20)23)7-12(9-21-17)14-8-13-5-6-16(14)22-13/h1-4,7,9,13-14,16,22H,5-6,8H2,(H2,20,23)
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1.87E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assay


J Med Chem 55: 6512-22 (2012)


Article DOI: 10.1021/jm300575y
BindingDB Entry DOI: 10.7270/Q2CV4JV0
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50395221
PNG
(CHEMBL2164663 | US9150581, RTI-7527-153)
Show SMILES Fc1ncc(cc1-c1ccc(cc1)C(F)(F)F)C1CC2CCC1N2 |THB:4:17:20.21:23|
Show InChI InChI=1S/C18H16F4N2/c19-17-15(10-1-3-12(4-2-10)18(20,21)22)7-11(9-23-17)14-8-13-5-6-16(14)24-13/h1-4,7,9,13-14,16,24H,5-6,8H2
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>2.00E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assay


J Med Chem 55: 6512-22 (2012)


Article DOI: 10.1021/jm300575y
BindingDB Entry DOI: 10.7270/Q2CV4JV0
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50395219
PNG
(CHEMBL2164665 | US9150581, RTI-7527-193)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1cc(cnc1F)C1CC2CCC1N2 |THB:12:17:20.21:23|
Show InChI InChI=1S/C17H18FN3O2S/c18-17-15(10-1-4-13(5-2-10)24(19,22)23)7-11(9-20-17)14-8-12-3-6-16(14)21-12/h1-2,4-5,7,9,12,14,16,21H,3,6,8H2,(H2,19,22,23)
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>2.00E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assay


J Med Chem 55: 6512-22 (2012)


Article DOI: 10.1021/jm300575y
BindingDB Entry DOI: 10.7270/Q2CV4JV0
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50395220
PNG
(CHEMBL2164664 | US9150581, RTI-7527-(+/-)-154)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(cnc1F)C1CC2CCC1N2 |THB:12:17:20.21:23|
Show InChI InChI=1S/C18H19FN2O2S/c1-24(22,23)14-5-2-11(3-6-14)16-8-12(10-20-18(16)19)15-9-13-4-7-17(15)21-13/h2-3,5-6,8,10,13,15,17,21H,4,7,9H2,1H3
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>2.00E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assay


J Med Chem 55: 6512-22 (2012)


Article DOI: 10.1021/jm300575y
BindingDB Entry DOI: 10.7270/Q2CV4JV0
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50151495
PNG
(2-[6-Fluoro-5-(4-nitro-phenyl)-pyridin-3-yl]-7-aza...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(cnc1F)C1CC2CCC1N2 |THB:11:16:22:20.19|
Show InChI InChI=1S/C17H16FN3O2/c18-17-15(10-1-4-13(5-2-10)21(22)23)7-11(9-19-17)14-8-12-3-6-16(14)20-12/h1-2,4-5,7,9,12,14,16,20H,3,6,8H2
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>2.00E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assay


J Med Chem 55: 6512-22 (2012)


Article DOI: 10.1021/jm300575y
BindingDB Entry DOI: 10.7270/Q2CV4JV0
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50395218
PNG
(CHEMBL2164666 | US9150581, RTI-7527-192)
Show SMILES Fc1ncc(cc1-c1ccc(cc1)S(=O)(=O)C(F)(F)F)C1CC2CCC1N2 |THB:4:20:23.24:26|
Show InChI InChI=1S/C18H16F4N2O2S/c19-17-15(7-11(9-23-17)14-8-12-3-6-16(14)24-12)10-1-4-13(5-2-10)27(25,26)18(20,21)22/h1-2,4-5,7,9,12,14,16,24H,3,6,8H2
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>2.00E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assay


J Med Chem 55: 6512-22 (2012)


Article DOI: 10.1021/jm300575y
BindingDB Entry DOI: 10.7270/Q2CV4JV0
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50171007
PNG
(4-[5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-2-fluoro-pyri...)
Show SMILES Fc1ncc(cc1-c1ccc(cc1)C#N)C1CC2CCC1N2 |TLB:4:15:21:19.18|
Show InChI InChI=1S/C18H16FN3/c19-18-16(12-3-1-11(9-20)2-4-12)7-13(10-21-18)15-8-14-5-6-17(15)22-14/h1-4,7,10,14-15,17,22H,5-6,8H2
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>2.00E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assay


J Med Chem 55: 6512-22 (2012)


Article DOI: 10.1021/jm300575y
BindingDB Entry DOI: 10.7270/Q2CV4JV0
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Rattus norvegicus (Rat))
BDBM50448763
PNG
(CHEMBL3128030)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1cc(cnc1F)[C@H]1C[C@H]2CC[C@H]1N2 |r,THB:11:16:19.20:22|
Show InChI InChI=1S/C17H16FN3O2/c18-17-15(10-2-1-3-13(6-10)21(22)23)7-11(9-19-17)14-8-12-4-5-16(14)20-12/h1-3,6-7,9,12,14,16,20H,4-5,8H2/t12-,14-,16-/m1/s1
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n/an/a 3.90E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current by two-elect...


J Med Chem 57: 836-48 (2014)


Article DOI: 10.1021/jm401602p
BindingDB Entry DOI: 10.7270/Q2JW8GDR
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50395221
PNG
(CHEMBL2164663 | US9150581, RTI-7527-153)
Show SMILES Fc1ncc(cc1-c1ccc(cc1)C(F)(F)F)C1CC2CCC1N2 |THB:4:17:20.21:23|
Show InChI InChI=1S/C18H16F4N2/c19-17-15(10-1-3-12(4-2-10)18(20,21)22)7-11(9-23-17)14-8-13-5-6-16(14)24-13/h1-4,7,9,13-14,16,24H,5-6,8H2
PDB

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UniProtKB/SwissProt

B.MOAD
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced response after 2 to 6 day...


J Med Chem 55: 6512-22 (2012)


Article DOI: 10.1021/jm300575y
BindingDB Entry DOI: 10.7270/Q2CV4JV0
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Rattus norvegicus (Rat))
BDBM50448767
PNG
(CHEMBL3128029)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(cnc1F)[C@H]1C[C@H]2CC[C@H]1N2 |r,THB:11:16:19.20:22|
Show InChI InChI=1S/C17H16FN3O2/c18-17-15(10-1-4-13(5-2-10)21(22)23)7-11(9-19-17)14-8-12-3-6-16(14)20-12/h1-2,4-5,7,9,12,14,16,20H,3,6,8H2/t12-,14-,16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.90E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current by two-elect...


J Med Chem 57: 836-48 (2014)


Article DOI: 10.1021/jm401602p
BindingDB Entry DOI: 10.7270/Q2JW8GDR
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit


(Rattus norvegicus (Rat))
BDBM50448766
PNG
(CHEMBL3128031)
Show SMILES Fc1ncc(cc1-c1ccncc1)[C@H]1C[C@H]2CC[C@H]1N2 |r,THB:4:13:16.17:19|
Show InChI InChI=1S/C16H16FN3/c17-16-14(10-3-5-18-6-4-10)7-11(9-19-16)13-8-12-1-2-15(13)20-12/h3-7,9,12-13,15,20H,1-2,8H2/t12-,13-,15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.00E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current by two-elect...


J Med Chem 57: 836-48 (2014)


Article DOI: 10.1021/jm401602p
BindingDB Entry DOI: 10.7270/Q2JW8GDR
More data for this
Ligand-Target Pair
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