new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 148 hits with Last Name = 'maccari' and Initial = 'l'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131709
PNG
(5-Chloro-2-{7-[4-(2-ethoxy-phenyl)-piperazin-1-yl]...)
Show SMILES CCOc1ccccc1N1CCN(CCCCCCCn2ncc(Cl)c(N3CCN(CC3)C(=O)c3ccco3)c2=O)CC1
Show InChI InChI=1S/C32H43ClN6O4/c1-2-42-28-12-7-6-11-27(28)36-18-16-35(17-19-36)14-8-4-3-5-9-15-39-32(41)30(26(33)25-34-39)37-20-22-38(23-21-37)31(40)29-13-10-24-43-29/h6-7,10-13,24-25H,2-5,8-9,14-23H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.350n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131714
PNG
(5-Chloro-4-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylme...)
Show SMILES COc1ccccc1N1CCN(CCCCCCCn2ncc(Cl)c(N3CCN(CC4COc5ccccc5O4)CC3)c2=O)CC1
Show InChI InChI=1S/C35H47ClN6O4/c1-44-31-12-6-5-11-30(31)40-21-17-38(18-22-40)15-9-3-2-4-10-16-42-35(43)34(29(36)25-37-42)41-23-19-39(20-24-41)26-28-27-45-32-13-7-8-14-33(32)46-28/h5-8,11-14,25,28H,2-4,9-10,15-24,26-27H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.400n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131707
PNG
(5-Chloro-4-[4-(furan-2-carbonyl)-piperazin-1-yl]-2...)
Show SMILES COc1ccccc1N1CCN(CCCCCCCn2ncc(Cl)c(N3CCN(CC3)C(=O)c3ccco3)c2=O)CC1
Show InChI InChI=1S/C31H41ClN6O4/c1-41-27-11-6-5-10-26(27)35-17-15-34(16-18-35)13-7-3-2-4-8-14-38-31(40)29(25(32)24-33-38)36-19-21-37(22-20-36)30(39)28-12-9-23-42-28/h5-6,9-12,23-24H,2-4,7-8,13-22H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.420n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50122242
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OC)c(=O)c1Cl
Show InChI InChI=1S/C36H51ClN6O4/c1-3-46-33-15-9-10-16-34(33)47-28-27-40-21-25-42(26-22-40)31-29-38-43(36(44)35(31)37)18-12-6-4-5-11-17-39-19-23-41(24-20-39)30-13-7-8-14-32(30)45-2/h7-10,13-16,29H,3-6,11-12,17-28H2,1-2H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.820n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50122243
PNG
(4-Chloro-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC3)C(=O)c3ccco3)c(Cl)c2=O)CC1
Show InChI InChI=1S/C33H45ClN6O4/c1-26(2)44-29-12-7-6-11-27(29)37-18-16-36(17-19-37)14-8-4-3-5-9-15-40-33(42)31(34)28(25-35-40)38-20-22-39(23-21-38)32(41)30-13-10-24-43-30/h6-7,10-13,24-26H,3-5,8-9,14-23H2,1-2H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.900n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131710
PNG
(5-Chloro-4-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylme...)
Show SMILES CCOc1ccccc1N1CCN(CCCCCCCn2ncc(Cl)c(N3CCN(CC4COc5ccccc5O4)CC3)c2=O)CC1
Show InChI InChI=1S/C36H49ClN6O4/c1-2-45-32-13-7-6-12-31(32)41-22-18-39(19-23-41)16-10-4-3-5-11-17-43-36(44)35(30(37)26-38-43)42-24-20-40(21-25-42)27-29-28-46-33-14-8-9-15-34(33)47-29/h6-9,12-15,26,29H,2-5,10-11,16-25,27-28H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.02n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131712
PNG
(5-Chloro-4-[4-(furan-2-carbonyl)-piperazin-1-yl]-2...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCCCCCn2ncc(Cl)c(N3CCN(CC3)C(=O)c3ccco3)c2=O)CC1
Show InChI InChI=1S/C33H45ClN6O4/c1-26(2)44-29-12-7-6-11-28(29)37-18-16-36(17-19-37)14-8-4-3-5-9-15-40-33(42)31(27(34)25-35-40)38-20-22-39(23-21-38)32(41)30-13-10-24-43-30/h6-7,10-13,24-26H,3-5,8-9,14-23H2,1-2H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.16n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50122238
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OCC)c(=O)c1Cl
Show InChI InChI=1S/C37H53ClN6O4/c1-3-46-33-15-9-8-14-31(33)42-24-20-40(21-25-42)18-12-6-5-7-13-19-44-37(45)36(38)32(30-39-44)43-26-22-41(23-27-43)28-29-48-35-17-11-10-16-34(35)47-4-2/h8-11,14-17,30H,3-7,12-13,18-29H2,1-2H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.32n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131711
PNG
(5-Chloro-4-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylme...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCCCCCn2ncc(Cl)c(N3CCN(CC4COc5ccccc5O4)CC3)c2=O)CC1
Show InChI InChI=1S/C37H51ClN6O4/c1-29(2)47-33-13-7-6-12-32(33)42-22-18-40(19-23-42)16-10-4-3-5-11-17-44-37(45)36(31(38)26-39-44)43-24-20-41(21-25-43)27-30-28-46-34-14-8-9-15-35(34)48-30/h6-9,12-15,26,29-30H,3-5,10-11,16-25,27-28H2,1-2H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.52n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
KEGG

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
2n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
KEGG

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
2n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131706
PNG
(4-Chloro-5-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylme...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC4COc5ccccc5O4)CC3)c(Cl)c2=O)CC1
Show InChI InChI=1S/C37H51ClN6O4/c1-29(2)47-33-13-7-6-12-31(33)42-22-18-40(19-23-42)16-10-4-3-5-11-17-44-37(45)36(38)32(26-39-44)43-24-20-41(21-25-43)27-30-28-46-34-14-8-9-15-35(34)48-30/h6-9,12-15,26,29-30H,3-5,10-11,16-25,27-28H2,1-2H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
2.47n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50122239
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OC(C)C)c(=O)c1Cl
Show InChI InChI=1S/C38H55ClN6O4/c1-4-47-35-16-10-11-17-36(35)48-29-28-42-22-26-44(27-23-42)33-30-40-45(38(46)37(33)39)19-13-7-5-6-12-18-41-20-24-43(25-21-41)32-14-8-9-15-34(32)49-31(2)3/h8-11,14-17,30-31H,4-7,12-13,18-29H2,1-3H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
2.54n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131708
PNG
(4-Chloro-5-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylme...)
Show SMILES COc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC4COc5ccccc5O4)CC3)c(Cl)c2=O)CC1
Show InChI InChI=1S/C35H47ClN6O4/c1-44-31-12-6-5-11-29(31)40-21-17-38(18-22-40)15-9-3-2-4-10-16-42-35(43)34(36)30(25-37-42)41-23-19-39(20-24-41)26-28-27-45-32-13-7-8-14-33(32)46-28/h5-8,11-14,25,28H,2-4,9-10,15-24,26-27H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
11.1n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50319673
PNG
(1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-...)
Show SMILES Fc1ccc(cc1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C21H27FN4O/c22-18-8-6-17(7-9-18)20-11-10-19(16-24-20)25-21(27)23-12-2-5-15-26-13-3-1-4-14-26/h6-11,16H,1-5,12-15H2,(H2,23,25,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
44n/an/an/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells


J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50131713
PNG
(4-Chloro-5-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylme...)
Show SMILES CCOc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC4COc5ccccc5O4)CC3)c(Cl)c2=O)CC1
Show InChI InChI=1S/C36H49ClN6O4/c1-2-45-32-13-7-6-12-30(32)41-22-18-39(19-23-41)16-10-4-3-5-11-17-43-36(44)35(37)31(26-38-43)42-24-20-40(21-25-42)27-29-28-46-33-14-8-9-15-34(33)47-29/h6-9,12-15,26,29H,2-5,10-11,16-25,27-28H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
49.8n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cortex membranes


J Med Chem 46: 3555-8 (2003)


Article DOI: 10.1021/jm0307842
BindingDB Entry DOI: 10.7270/Q2VX0FWQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117131
PNG
(6-(1H-imidazol-1-yl)-2-(7-(4-(2-methoxyphenyl)pipe...)
Show SMILES COc1ccccc1N1CCN(CCCCCCCn2nc(ccc2=O)-n2ccnc2)CC1
Show InChI InChI=1S/C25H34N6O2/c1-33-23-10-6-5-9-22(23)29-19-17-28(18-20-29)14-7-3-2-4-8-15-31-25(32)12-11-24(27-31)30-16-13-26-21-30/h5-6,9-13,16,21H,2-4,7-8,14-15,17-20H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
98.7n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117123
PNG
(6-(1H-indol-1-yl)-2-(3-(4-(2-methoxyphenyl)piperaz...)
Show SMILES COc1ccccc1N1CCN(CCCn2nc(ccc2=O)-n2ccc3ccccc23)CC1
Show InChI InChI=1S/C26H29N5O2/c1-33-24-10-5-4-9-23(24)29-19-17-28(18-20-29)14-6-15-31-26(32)12-11-25(27-31)30-16-13-21-7-2-3-8-22(21)30/h2-5,7-13,16H,6,14-15,17-20H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
103n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117127
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(6-(4-(2-methoxyphe...)
Show SMILES COc1ccccc1N1CCN(CCCCCCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C28H34N6O2/c1-36-26-13-7-6-12-25(26)32-20-18-31(19-21-32)16-8-2-3-9-17-34-28(35)15-14-27(30-34)33-22-29-23-10-4-5-11-24(23)33/h4-7,10-15,22H,2-3,8-9,16-21H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
106n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117116
PNG
(2-(7-(4-(2-chlorophenyl)piperazin-1-yl)heptyl)-6-(...)
Show SMILES Clc1ccccc1N1CCN(CCCCCCCn2nc(ccc2=O)-n2ccnc2)CC1
Show InChI InChI=1S/C24H31ClN6O/c25-21-8-4-5-9-22(21)29-18-16-28(17-19-29)13-6-2-1-3-7-14-31-24(32)11-10-23(27-31)30-15-12-26-20-30/h4-5,8-12,15,20H,1-3,6-7,13-14,16-19H2
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
123n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117140
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(5-(4-(2-methoxyphe...)
Show SMILES COc1ccccc1N1CCN(CCCCCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C27H32N6O2/c1-35-25-12-6-5-11-24(25)31-19-17-30(18-20-31)15-7-2-8-16-33-27(34)14-13-26(29-33)32-21-28-22-9-3-4-10-23(22)32/h3-6,9-14,21H,2,7-8,15-20H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
127n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117129
PNG
(6-(1H-indol-1-yl)-2-(5-(4-(2-methoxyphenyl)piperaz...)
Show SMILES COc1ccccc1N1CCN(CCCCCn2nc(ccc2=O)-n2ccc3ccccc23)CC1
Show InChI InChI=1S/C28H33N5O2/c1-35-26-12-6-5-11-25(26)31-21-19-30(20-22-31)16-7-2-8-17-33-28(34)14-13-27(29-33)32-18-15-23-9-3-4-10-24(23)32/h3-6,9-15,18H,2,7-8,16-17,19-22H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
141n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117126
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(4-(4-(2-chlorophen...)
Show SMILES Clc1ccccc1N1CCN(CCCCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C25H27ClN6O/c26-20-7-1-3-9-22(20)30-17-15-29(16-18-30)13-5-6-14-32-25(33)12-11-24(28-32)31-19-27-21-8-2-4-10-23(21)31/h1-4,7-12,19H,5-6,13-18H2
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
181n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117119
PNG
(6-(1H-indol-1-yl)-2-(7-(4-(2-methoxyphenyl)piperaz...)
Show SMILES COc1ccccc1N1CCN(CCCCCCCn2nc(ccc2=O)-n2ccc3ccccc23)CC1
Show InChI InChI=1S/C30H37N5O2/c1-37-28-14-8-7-13-27(28)33-23-21-32(22-24-33)18-9-3-2-4-10-19-35-30(36)16-15-29(31-35)34-20-17-25-11-5-6-12-26(25)34/h5-8,11-17,20H,2-4,9-10,18-19,21-24H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
181n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117118
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(7-(4-(2-chlorophen...)
Show SMILES Clc1ccccc1N1CCN(CCCCCCCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C28H33ClN6O/c29-23-10-4-6-12-25(23)33-20-18-32(19-21-33)16-8-2-1-3-9-17-35-28(36)15-14-27(31-35)34-22-30-24-11-5-7-13-26(24)34/h4-7,10-15,22H,1-3,8-9,16-21H2
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
182n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117132
PNG
(6-(1H-imidazol-1-yl)-2-(5-(4-(2-methoxyphenyl)pipe...)
Show SMILES COc1ccccc1N1CCN(CCCCCn2nc(ccc2=O)-n2ccnc2)CC1
Show InChI InChI=1S/C23H30N6O2/c1-31-21-8-4-3-7-20(21)27-17-15-26(16-18-27)12-5-2-6-13-29-23(30)10-9-22(25-29)28-14-11-24-19-28/h3-4,7-11,14,19H,2,5-6,12-13,15-18H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
223n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117128
PNG
(6-(1H-indol-1-yl)-2-(4-(4-(2-methoxyphenyl)piperaz...)
Show SMILES COc1ccccc1N1CCN(CCCCn2nc(ccc2=O)-n2ccc3ccccc23)CC1
Show InChI InChI=1S/C27H31N5O2/c1-34-25-11-5-4-10-24(25)30-20-18-29(19-21-30)15-6-7-16-32-27(33)13-12-26(28-32)31-17-14-22-8-2-3-9-23(22)31/h2-5,8-14,17H,6-7,15-16,18-21H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
253n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117117
PNG
(6-(1H-indol-1-yl)-2-(2-(4-(2-methoxyphenyl)piperaz...)
Show SMILES COc1ccccc1N1CCN(CCn2nc(ccc2=O)-n2ccc3ccccc23)CC1
Show InChI InChI=1S/C25H27N5O2/c1-32-23-9-5-4-8-22(23)28-17-14-27(15-18-28)16-19-30-25(31)11-10-24(26-30)29-13-12-20-6-2-3-7-21(20)29/h2-13H,14-19H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
310n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50109283
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(4-(4-(2-methoxyphe...)
Show SMILES COc1ccccc1N1CCN(CCCCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C26H30N6O2/c1-34-24-11-5-4-10-23(24)30-18-16-29(17-19-30)14-6-7-15-32-26(33)13-12-25(28-32)31-20-27-21-8-2-3-9-22(21)31/h2-5,8-13,20H,6-7,14-19H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
315n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117124
PNG
(2-{5-[4-(2-Chloro-phenyl)-piperazin-1-yl]-pentyl}-...)
Show SMILES Clc1ccccc1N1CCN(CCCCCn2nc(ccc2=O)-n2ccnc2)CC1
Show InChI InChI=1S/C22H27ClN6O/c23-19-6-2-3-7-20(19)27-16-14-26(15-17-27)11-4-1-5-12-29-22(30)9-8-21(25-29)28-13-10-24-18-28/h2-3,6-10,13,18H,1,4-5,11-12,14-17H2
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
323n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117139
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(5-(4-(2-chlorophen...)
Show SMILES Clc1ccccc1N1CCN(CCCCCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C26H29ClN6O/c27-21-8-2-4-10-23(21)31-18-16-30(17-19-31)14-6-1-7-15-33-26(34)13-12-25(29-33)32-20-28-22-9-3-5-11-24(22)32/h2-5,8-13,20H,1,6-7,14-19H2
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
351n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50109287
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(3-(4-(2-methoxyphe...)
Show SMILES COc1ccccc1N1CCN(CCCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C25H28N6O2/c1-33-23-10-5-4-9-22(23)29-17-15-28(16-18-29)13-6-14-31-25(32)12-11-24(27-31)30-19-26-20-7-2-3-8-21(20)30/h2-5,7-12,19H,6,13-18H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
382n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50399292
PNG
(CHEMBL2180842)
Show SMILES Fc1cncc(c1)-c1cc(NC(=O)CCCN2CCCCC2)[nH]n1
Show InChI InChI=1S/C17H22FN5O/c18-14-9-13(11-19-12-14)15-10-16(22-21-15)20-17(24)5-4-8-23-6-2-1-3-7-23/h9-12H,1-8H2,(H2,20,21,22,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
390n/an/an/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from rat alpha7 nAchR expressed in rat GH4C1 cell membranes


J Med Chem 55: 10277-81 (2012)


Article DOI: 10.1021/jm3013568
BindingDB Entry DOI: 10.7270/Q2DJ5GRD
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50109284
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(3-(4-(2-chlorophen...)
Show SMILES Clc1ccccc1N1CCN(CCCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C24H25ClN6O/c25-19-6-1-3-8-21(19)29-16-14-28(15-17-29)12-5-13-31-24(32)11-10-23(27-31)30-18-26-20-7-2-4-9-22(20)30/h1-4,6-11,18H,5,12-17H2
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
461n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50109286
PNG
(6-(1H-imidazol-1-yl)-2-(3-(4-(2-methoxyphenyl)pipe...)
Show SMILES COc1ccccc1N1CCN(CCCn2nc(ccc2=O)-n2ccnc2)CC1
Show InChI InChI=1S/C21H26N6O2/c1-29-19-6-3-2-5-18(19)25-15-13-24(14-16-25)10-4-11-27-21(28)8-7-20(23-27)26-12-9-22-17-26/h2-3,5-9,12,17H,4,10-11,13-16H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
463n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117133
PNG
(6-(1H-indol-1-yl)-2-(6-(4-(2-methoxyphenyl)piperaz...)
Show SMILES COc1ccccc1N1CCN(CCCCCCn2nc(ccc2=O)-n2ccc3ccccc23)CC1
Show InChI InChI=1S/C29H35N5O2/c1-36-27-13-7-6-12-26(27)32-22-20-31(21-23-32)17-8-2-3-9-18-34-29(35)15-14-28(30-34)33-19-16-24-10-4-5-11-25(24)33/h4-7,10-16,19H,2-3,8-9,17-18,20-23H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
514n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117125
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(2-(4-(2-methoxyphe...)
Show SMILES COc1ccccc1N1CCN(CCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C24H26N6O2/c1-32-22-9-5-4-8-21(22)28-15-12-27(13-16-28)14-17-30-24(31)11-10-23(26-30)29-18-25-19-6-2-3-7-20(19)29/h2-11,18H,12-17H2,1H3
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
541n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50109285
PNG
(2-(3-(4-(2-chlorophenyl)piperazin-1-yl)propyl)-6-(...)
Show SMILES Clc1ccccc1N1CCN(CCCn2nc(ccc2=O)-n2ccnc2)CC1
Show InChI InChI=1S/C20H23ClN6O/c21-17-4-1-2-5-18(17)25-14-12-24(13-15-25)9-3-10-27-20(28)7-6-19(23-27)26-11-8-22-16-26/h1-2,4-8,11,16H,3,9-10,12-15H2
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
617n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117135
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(6-(4-(2-chlorophen...)
Show SMILES Clc1ccccc1N1CCN(CCCCCCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C27H31ClN6O/c28-22-9-3-5-11-24(22)32-19-17-31(18-20-32)15-7-1-2-8-16-34-27(35)14-13-26(30-34)33-21-29-23-10-4-6-12-25(23)33/h3-6,9-14,21H,1-2,7-8,15-20H2
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
617n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50399293
PNG
(CHEMBL2086582)
Show SMILES COc1ccc(cc1)-c1cc(NC(=O)CCCCN2CCCN(CC2)C(C)=O)[nH]n1
Show InChI InChI=1S/C22H31N5O3/c1-17(28)27-13-5-12-26(14-15-27)11-4-3-6-22(29)23-21-16-20(24-25-21)18-7-9-19(30-2)10-8-18/h7-10,16H,3-6,11-15H2,1-2H3,(H2,23,24,25,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
660n/an/an/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in GH4C1 cells after 1 hr by TopCount method


J Med Chem 55: 4806-23 (2012)


Article DOI: 10.1021/jm300247y
BindingDB Entry DOI: 10.7270/Q2VM4DJ7
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50117130
PNG
(6-(1H-benzo[d]imidazol-1-yl)-2-(2-(4-(2-chlorophen...)
Show SMILES Clc1ccccc1N1CCN(CCn2nc(ccc2=O)-n2cnc3ccccc23)CC1
Show InChI InChI=1S/C23H23ClN6O/c24-18-5-1-3-7-20(18)28-14-11-27(12-15-28)13-16-30-23(31)10-9-22(26-30)29-17-25-19-6-2-4-8-21(19)29/h1-10,17H,11-16H2
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
1.01E+3n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane


J Med Chem 45: 3603-11 (2002)


BindingDB Entry DOI: 10.7270/Q2NV9HMT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50319673
PNG
(1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-...)
Show SMILES Fc1ccc(cc1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C21H27FN4O/c22-18-8-6-17(7-9-18)20-11-10-19(16-24-20)25-21(27)23-12-2-5-15-26-13-3-1-4-14-26/h6-11,16H,1-5,12-15H2,(H2,23,25,27)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
6.00E+3n/an/an/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Binding affinity to 5HT4 receptor


J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50399295
PNG
(CHEMBL2180841)
Show SMILES Fc1cccc(c1)-c1cc(NC(=O)CCCN2CCCCC2)[nH]n1
Show InChI InChI=1S/C18H23FN4O/c19-15-7-4-6-14(12-15)16-13-17(22-21-16)20-18(24)8-5-11-23-9-2-1-3-10-23/h4,6-7,12-13H,1-3,5,8-11H2,(H2,20,21,22,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.29E+3n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Inhibition of human ERG expressed in CHO cells


J Med Chem 55: 10277-81 (2012)


Article DOI: 10.1021/jm3013568
BindingDB Entry DOI: 10.7270/Q2DJ5GRD
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50319673
PNG
(1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-...)
Show SMILES Fc1ccc(cc1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C21H27FN4O/c22-18-8-6-17(7-9-18)20-11-10-19(16-24-20)25-21(27)23-12-2-5-15-26-13-3-1-4-14-26/h6-11,16H,1-5,12-15H2,(H2,23,25,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Binding affinity to human ERG expressed in CHO cells


J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50399294
PNG
(CHEMBL2180840)
Show SMILES COc1cccc(c1)-c1cc(NC(=O)CCCN2CCCCC2)[nH]n1
Show InChI InChI=1S/C19H26N4O2/c1-25-16-8-5-7-15(13-16)17-14-18(22-21-17)20-19(24)9-6-12-23-10-3-2-4-11-23/h5,7-8,13-14H,2-4,6,9-12H2,1H3,(H2,20,21,22,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.08E+3n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Inhibition of human ERG expressed in CHO cells


J Med Chem 55: 10277-81 (2012)


Article DOI: 10.1021/jm3013568
BindingDB Entry DOI: 10.7270/Q2DJ5GRD
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta2


(Homo sapiens (Human))
BDBM50420604
PNG
(CHEMBL2087443)
Show SMILES COc1ccc(cc1)-c1cc(NC(=O)CCCCN2CCCCC2)[nH]n1
Show InChI InChI=1S/C20H28N4O2/c1-26-17-10-8-16(9-11-17)18-15-19(23-22-18)21-20(25)7-3-6-14-24-12-4-2-5-13-24/h8-11,15H,2-7,12-14H2,1H3,(H2,21,22,23,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.25E+3n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Antagonist activity at human alpha3 receptor in SH-SY5Y cells assessed as inhibition of epibatidine-induced membrane potential measured every 1 sec f...


J Med Chem 55: 4806-23 (2012)


Article DOI: 10.1021/jm300247y
BindingDB Entry DOI: 10.7270/Q2VM4DJ7
More data for this
Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta2


(Homo sapiens (Human))
BDBM50420606
PNG
(CHEMBL2087447)
Show SMILES Fc1ccc(cc1)-c1cc(NC(=O)CCCCN2CCCCC2)[nH]n1
Show InChI InChI=1S/C19H25FN4O/c20-16-9-7-15(8-10-16)17-14-18(23-22-17)21-19(25)6-2-5-13-24-11-3-1-4-12-24/h7-10,14H,1-6,11-13H2,(H2,21,22,23,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.90E+3n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Antagonist activity at human alpha3 receptor in SH-SY5Y cells assessed as inhibition of epibatidine-induced membrane potential measured every 1 sec f...


J Med Chem 55: 4806-23 (2012)


Article DOI: 10.1021/jm300247y
BindingDB Entry DOI: 10.7270/Q2VM4DJ7
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50399289
PNG
(CHEMBL2180835)
Show SMILES COc1ccc(cc1)-c1cc(NC(=O)CCCN2CCCCC2)[nH]n1
Show InChI InChI=1S/C19H26N4O2/c1-25-16-9-7-15(8-10-16)17-14-18(22-21-17)20-19(24)6-5-13-23-11-3-2-4-12-23/h7-10,14H,2-6,11-13H2,1H3,(H2,20,21,22,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.61E+3n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Inhibition of human ERG expressed in CHO cells


J Med Chem 55: 10277-81 (2012)


Article DOI: 10.1021/jm3013568
BindingDB Entry DOI: 10.7270/Q2DJ5GRD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM50319676
PNG
(1-(2'-fluorobiphenyl-4-yl)-3-(4-(piperidin-1-yl)bu...)
Show SMILES Fc1ccccc1-c1ccc(NC(=O)NCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C22H28FN3O/c23-21-9-3-2-8-20(21)18-10-12-19(13-11-18)25-22(27)24-14-4-7-17-26-15-5-1-6-16-26/h2-3,8-13H,1,4-7,14-17H2,(H2,24,25,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 5.70E+3n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay


J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM50319677
PNG
(1-(4'-fluorobiphenyl-4-yl)-3-(4-(piperidin-1-yl)bu...)
Show SMILES Fc1ccc(cc1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C22H28FN3O/c23-20-10-6-18(7-11-20)19-8-12-21(13-9-19)25-22(27)24-14-2-5-17-26-15-3-1-4-16-26/h6-13H,1-5,14-17H2,(H2,24,25,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 5.80E+3n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay


J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 148 total )  |  Next  |  Last  >>
Jump to: