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Compile Data Set for Download or QSAR

Found 879 hits with Last Name = 'magoc' and Initial = 'tj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062051
PNG
(1-Dimethylcarbamoyl-6-(4-fluoro-phenyl)-3-[4-(2-me...)
Show SMILES COC(=O)c1cc(cc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C34H28FN5O4/c1-20-37-28-17-36-14-13-29(28)39(20)18-21-5-7-23(8-6-21)32(41)27-19-40(34(43)38(2)3)30-16-24(22-9-11-25(35)12-10-22)15-26(31(27)30)33(42)44-4/h5-17,19H,18H2,1-4H3
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0.150n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062066
PNG
(3-[4-(2-Methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-b...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)S(=O)(=O)C(C)C
Show InChI InChI=1S/C28H26N4O5S/c1-17(2)38(35,36)32-16-22(26-21(28(34)37-4)6-5-7-25(26)32)27(33)20-10-8-19(9-11-20)15-31-18(3)30-23-14-29-13-12-24(23)31/h5-14,16-17H,15H2,1-4H3
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0.190n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286027
PNG
(6-(4-Fluoro-phenyl)-3-[[(Z)-hydroxyimino]-((R)-3-p...)
Show SMILES CN(C)C(=O)n1cc(C(N=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H24FN5O2S/c1-33(2)29(36)35-16-24(22-10-7-19(14-25(22)35)18-5-8-21(30)9-6-18)27(32-37)23-11-13-34-26(23)17-38-28(34)20-4-3-12-31-15-20/h3-16,27-28H,17H2,1-2H3/t27?,28-/m1/s1
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0.370n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50048485
PNG
((S)-4-Methyl-2-{methyl-[4-(2-methyl-imidazo[4,5-c]...)
Show SMILES CCOC(=O)[C@H](CC(C)C)N(C)S(=O)(=O)c1ccc(Cn2c(C)nc3cnccc23)cc1
Show InChI InChI=1S/C23H30N4O4S/c1-6-31-23(28)22(13-16(2)3)26(5)32(29,30)19-9-7-18(8-10-19)15-27-17(4)25-20-14-24-12-11-21(20)27/h7-12,14,16,22H,6,13,15H2,1-5H3/t22-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
The compound was evaluated for its binding affinity against PAF receptor in rabbit platelet


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50048485
PNG
((S)-4-Methyl-2-{methyl-[4-(2-methyl-imidazo[4,5-c]...)
Show SMILES CCOC(=O)[C@H](CC(C)C)N(C)S(=O)(=O)c1ccc(Cn2c(C)nc3cnccc23)cc1
Show InChI InChI=1S/C23H30N4O4S/c1-6-31-23(28)22(13-16(2)3)26(5)32(29,30)19-9-7-18(8-10-19)15-27-17(4)25-20-14-24-12-11-21(20)27/h7-12,14,16,22H,6,13,15H2,1-5H3/t22-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
The compound was evaluated for its binding affinity against PAF receptor in rabbit platelet


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062069
PNG
(4-Methoxy-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-y...)
Show SMILES COC(=O)c1[nH]c2cccc(OC)c2c1C(=O)c1ccc(Cn2c(C)nc3cnccc23)cc1
Show InChI InChI=1S/C26H22N4O4/c1-15-28-19-13-27-12-11-20(19)30(15)14-16-7-9-17(10-8-16)25(31)23-22-18(5-4-6-21(22)33-2)29-24(23)26(32)34-3/h4-13,29H,14H2,1-3H3
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0.510n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062101
PNG
(4-Ethynyl-3-[3-fluoro-4-(2-methyl-imidazo[4,5-c]py...)
Show SMILES CNC(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)c(F)c2)c2c(cccc12)C#C
Show InChI InChI=1S/C27H20FN5O2/c1-4-17-6-5-7-24-25(17)20(15-33(24)27(35)29-3)26(34)18-8-9-19(21(28)12-18)14-32-16(2)31-22-13-30-11-10-23(22)32/h1,5-13,15H,14H2,2-3H3,(H,29,35)
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0.630n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062056
PNG
(1-Dimethylcarbamoyl-3-{2-[4-(2-methyl-imidazo[4,5-...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)Cc3ccc(cc3)-n3c(C)nc4cnccc34)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H25N5O4/c1-17-30-22-15-29-13-12-23(22)33(17)19-10-8-18(9-11-19)14-25(34)21-16-32(28(36)31(2)3)24-7-5-6-20(26(21)24)27(35)37-4/h5-13,15-16H,14H2,1-4H3
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0.630n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062061
PNG
(1-(3,3-Dimethyl-2-oxo-butyl)-3-[4-(2-methyl-imidaz...)
Show SMILES COC(=O)c1cccc2n(CC(=O)C(C)(C)C)cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12
Show InChI InChI=1S/C31H30N4O4/c1-19-33-24-15-32-14-13-25(24)35(19)16-20-9-11-21(12-10-20)29(37)23-17-34(18-27(36)31(2,3)4)26-8-6-7-22(28(23)26)30(38)39-5/h6-15,17H,16,18H2,1-5H3
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0.670n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285986
PNG
(2-[6-(4-Fluoro-phenyl)-3-(3-pyridin-3-yl-1H-pyrrol...)
Show SMILES CN(C)C(=O)Cn1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C30H25FN4O2S/c1-33(2)28(36)17-34-16-25(23-10-7-20(14-26(23)34)19-5-8-22(31)9-6-19)29(37)24-11-13-35-27(24)18-38-30(35)21-4-3-12-32-15-21/h3-16,30H,17-18H2,1-2H3
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0.700n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062045
PNG
(6-Benzofuran-2-yl-1-dimethylcarbamoyl-3-[4-(2-meth...)
Show SMILES COC(=O)c1cc(cc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C)-c1cc2ccccc2o1
Show InChI InChI=1S/C36H29N5O5/c1-21-38-28-18-37-14-13-29(28)40(21)19-22-9-11-23(12-10-22)34(42)27-20-41(36(44)39(2)3)30-16-25(15-26(33(27)30)35(43)45-4)32-17-24-7-5-6-8-31(24)46-32/h5-18,20H,19H2,1-4H3
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0.780n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062082
PNG
(4-Methyl-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(C)cccc12
Show InChI InChI=1S/C27H25N5O2/c1-17-6-5-7-24-25(17)21(16-32(24)27(34)30(3)4)26(33)20-10-8-19(9-11-20)15-31-18(2)29-22-14-28-13-12-23(22)31/h5-14,16H,15H2,1-4H3
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0.820n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062113
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H25N5O4/c1-17-30-22-14-29-13-12-23(22)32(17)15-18-8-10-19(11-9-18)26(34)21-16-33(28(36)31(2)3)24-7-5-6-20(25(21)24)27(35)37-4/h5-14,16H,15H2,1-4H3
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0.850n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062064
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(cccc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C34H29N5O4/c1-22-36-28-18-35-17-16-29(28)38(22)19-23-12-14-25(15-13-23)32(40)27-20-39(34(42)37(2)3)30-11-7-10-26(31(27)30)33(41)43-21-24-8-5-4-6-9-24/h4-18,20H,19,21H2,1-3H3
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0.860n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062092
PNG
((4,7-Dimethyl-1H-indol-3-yl)-[4-(2-methyl-imidazo[...)
Show SMILES Cc1nc2cnccc2n1Cc1ccc(cc1)C(=O)c1c[nH]c2c(C)ccc(C)c12
Show InChI InChI=1S/C25H22N4O/c1-15-4-5-16(2)24-23(15)20(12-27-24)25(30)19-8-6-18(7-9-19)14-29-17(3)28-21-13-26-11-10-22(21)29/h4-13,27H,14H2,1-3H3
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0.870n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062106
PNG
(4-Chloro-3-[4-(2-methyl-imidazo[4,5-b]pyridin-1-yl...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4ncccc34)cc2)c2c(Cl)cccc12
Show InChI InChI=1S/C26H22ClN5O2/c1-16-29-25-22(8-5-13-28-25)31(16)14-17-9-11-18(12-10-17)24(33)19-15-32(26(34)30(2)3)21-7-4-6-20(27)23(19)21/h4-13,15H,14H2,1-3H3
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0.900n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062118
PNG
(4-Ethyl-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-ylm...)
Show SMILES CCc1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H27N5O2/c1-5-20-7-6-8-25-26(20)22(17-33(25)28(35)31(3)4)27(34)21-11-9-19(10-12-21)16-32-18(2)30-23-15-29-14-13-24(23)32/h6-15,17H,5,16H2,1-4H3
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0.910n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062048
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-benzoimidazol-1...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5ccccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C29H26N4O4/c1-18-30-23-9-5-6-10-24(23)32(18)16-19-12-14-20(15-13-19)27(34)22-17-33(29(36)31(2)3)25-11-7-8-21(26(22)25)28(35)37-4/h5-15,17H,16H2,1-4H3
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0.920n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062098
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES COC(=O)c1cc(cc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C)C#Cc1ccccc1
Show InChI InChI=1S/C36H29N5O4/c1-23-38-30-20-37-17-16-31(30)40(23)21-25-12-14-27(15-13-25)34(42)29-22-41(36(44)39(2)3)32-19-26(11-10-24-8-6-5-7-9-24)18-28(33(29)32)35(43)45-4/h5-9,12-20,22H,21H2,1-4H3
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0.950n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062054
PNG
(4-Ethynyl-3-[3-fluoro-4-(2-methyl-imidazo[4,5-c]py...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)c(F)c2)c2c(cccc12)C#C
Show InChI InChI=1S/C28H22FN5O2/c1-5-18-7-6-8-25-26(18)21(16-34(25)28(36)32(3)4)27(35)19-9-10-20(22(29)13-19)15-33-17(2)31-23-14-30-12-11-24(23)33/h1,6-14,16H,15H2,2-4H3
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1n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062054
PNG
(4-Ethynyl-3-[3-fluoro-4-(2-methyl-imidazo[4,5-c]py...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)c(F)c2)c2c(cccc12)C#C
Show InChI InChI=1S/C28H22FN5O2/c1-5-18-7-6-8-25-26(18)21(16-34(25)28(36)32(3)4)27(35)19-9-10-20(22(29)13-19)15-33-17(2)31-23-14-30-12-11-24(23)33/h1,6-14,16H,15H2,2-4H3
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1n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM220447
PNG
(US9296741, 36)
Show SMILES CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H19F2N3O4S/c1-3-32(29,30)26-14-5-7-19(31-20-6-4-13(23)10-18(20)24)16(11-14)17-12-27(2)22(28)21-15(17)8-9-25-21/h4-12,25-26H,3H2,1-2H3
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1n/an/an/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL




J Med Chem 60: 8369-8384 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00746
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062091
PNG
(1-(2-Ethoxy-ethyl)-3-[4-(2-methyl-imidazo[4,5-c]py...)
Show SMILES CCOCCn1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(cccc12)C(=O)OC
Show InChI InChI=1S/C29H28N4O4/c1-4-37-15-14-32-18-23(27-22(29(35)36-3)6-5-7-26(27)32)28(34)21-10-8-20(9-11-21)17-33-19(2)31-24-16-30-13-12-25(24)33/h5-13,16,18H,4,14-15,17H2,1-3H3
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1.10n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062058
PNG
(6-(4-Fluoro-phenyl)-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(c2ccc(cc12)-c1ccc(F)cc1)S(=O)(=O)N1CCN(Cn2c(C)nc3cnccc23)CC1
Show InChI InChI=1S/C29H30FN7O3S/c1-20-32-25-17-31-11-10-26(25)37(20)19-34-12-14-35(15-13-34)41(39,40)28-18-36(29(38)33(2)3)27-16-22(6-9-24(27)28)21-4-7-23(30)8-5-21/h4-11,16-18H,12-15,19H2,1-3H3
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1.20n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062049
PNG
(CHEMBL367964 | [7-(4-Fluoro-phenyl)-1H-indol-3-yl]...)
Show SMILES Cc1nc2cnccc2n1Cc1ccc(cc1)C(=O)c1c[nH]c2c(cccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H21FN4O/c1-18-33-26-16-31-14-13-27(26)34(18)17-19-5-7-21(8-6-19)29(35)25-15-32-28-23(3-2-4-24(25)28)20-9-11-22(30)12-10-20/h2-16,32H,17H2,1H3
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1.30n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062110
PNG
(1-Isopropyl-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(C)C
Show InChI InChI=1S/C28H26N4O3/c1-17(2)31-16-22(26-21(28(34)35-4)6-5-7-25(26)31)27(33)20-10-8-19(9-11-20)15-32-18(3)30-23-14-29-13-12-24(23)32/h5-14,16-17H,15H2,1-4H3
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1.30n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062084
PNG
(4-Ethynyl-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-y...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(cccc12)C#C
Show InChI InChI=1S/C28H23N5O2/c1-5-20-7-6-8-25-26(20)22(17-33(25)28(35)31(3)4)27(34)21-11-9-19(10-12-21)16-32-18(2)30-23-15-29-14-13-24(23)32/h1,6-15,17H,16H2,2-4H3
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1.30n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062128
PNG
(6-Bromo-1-dimethylcarbamoyl-3-[4-(2-methyl-imidazo...)
Show SMILES COC(=O)c1cc(Br)cc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H24BrN5O4/c1-16-31-22-13-30-10-9-23(22)33(16)14-17-5-7-18(8-6-17)26(35)21-15-34(28(37)32(2)3)24-12-19(29)11-20(25(21)24)27(36)38-4/h5-13,15H,14H2,1-4H3
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1.40n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062107
PNG
(1-Methylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]pyr...)
Show SMILES CNC(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(cccc12)C(=O)OC
Show InChI InChI=1S/C27H23N5O4/c1-16-30-21-13-29-12-11-22(21)31(16)14-17-7-9-18(10-8-17)25(33)20-15-32(27(35)28-2)23-6-4-5-19(24(20)23)26(34)36-3/h4-13,15H,14H2,1-3H3,(H,28,35)
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1.5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
BRD4/HDAC1


(Homo sapiens (Human))
BDBM220447
PNG
(US9296741, 36)
Show SMILES CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H19F2N3O4S/c1-3-32(29,30)26-14-5-7-19(31-20-6-4-13(23)10-18(20)24)16(11-14)17-12-27(2)22(28)21-15(17)8-9-25-21/h4-12,25-26H,3H2,1-2H3
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1.5n/an/an/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL




J Med Chem 60: 8369-8384 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00746
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062126
PNG
(1-Carbamoyl-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(N)=O
Show InChI InChI=1S/C26H21N5O4/c1-15-29-20-12-28-11-10-21(20)30(15)13-16-6-8-17(9-7-16)24(32)19-14-31(26(27)34)22-5-3-4-18(23(19)22)25(33)35-2/h3-12,14H,13H2,1-2H3,(H2,27,34)
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1.5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
BRD4/HDAC1


(Homo sapiens (Human))
BDBM220432
PNG
(US9296741, 21)
Show SMILES CCS(=O)(=O)Nc1ccc(Oc2ccccc2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H21N3O4S/c1-3-30(27,28)24-15-9-10-20(29-16-7-5-4-6-8-16)18(13-15)19-14-25(2)22(26)21-17(19)11-12-23-21/h4-14,23-24H,3H2,1-2H3
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1.5n/an/an/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human placental aldose reductase


J Med Chem 60: 8369-8384 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00746
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062108
PNG
(4-Ethynyl-3-{[3-fluoro-4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(O)c2ccc(Cn3c(C)nc4cnccc34)c(F)c2)c2c(cccc12)C#C
Show InChI InChI=1S/C28H24FN5O2/c1-5-18-7-6-8-25-26(18)21(16-34(25)28(36)32(3)4)27(35)19-9-10-20(22(29)13-19)15-33-17(2)31-23-14-30-12-11-24(23)33/h1,6-14,16,27,35H,15H2,2-4H3
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1.5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062081
PNG
(3-[4-(2-Methyl-benzoimidazol-1-ylmethyl)-benzoyl]-...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5ccccc45)cc3)c12)C(=O)N1CCCC1
Show InChI InChI=1S/C31H28N4O4/c1-20-32-25-9-3-4-10-26(25)34(20)18-21-12-14-22(15-13-21)29(36)24-19-35(31(38)33-16-5-6-17-33)27-11-7-8-23(28(24)27)30(37)39-2/h3-4,7-15,19H,5-6,16-18H2,1-2H3
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1.70n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285993
PNG
(6-(4-Fluoro-phenoxy)-3-(3-pyridin-3-yl-1H-pyrrolo[...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(Oc3ccc(F)cc3)cc12
Show InChI InChI=1S/C29H23FN4O3S/c1-32(2)29(36)34-16-24(22-10-9-21(14-25(22)34)37-20-7-5-19(30)6-8-20)27(35)23-11-13-33-26(23)17-38-28(33)18-4-3-12-31-15-18/h3-16,28H,17H2,1-2H3
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1.70n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062121
PNG
(3-[4-(4-Chloro-2-methyl-imidazo[4,5-c]pyridin-1-yl...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5c(Cl)nccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H24ClN5O4/c1-16-31-24-22(12-13-30-26(24)29)33(16)14-17-8-10-18(11-9-17)25(35)20-15-34(28(37)32(2)3)21-7-5-6-19(23(20)21)27(36)38-4/h5-13,15H,14H2,1-4H3
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1.80n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062054
PNG
(4-Ethynyl-3-[3-fluoro-4-(2-methyl-imidazo[4,5-c]py...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)c(F)c2)c2c(cccc12)C#C
Show InChI InChI=1S/C28H22FN5O2/c1-5-18-7-6-8-25-26(18)21(16-34(25)28(36)32(3)4)27(35)19-9-10-20(22(29)13-19)15-33-17(2)31-23-14-30-12-11-24(23)33/h1,6-14,16H,15H2,2-4H3
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1.80n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
The compound was evaluated for its binding affinity against PAF receptor in rabbit platelet


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062077
PNG
(4-Benzoylamino-3-[4-(2-methyl-imidazo[4,5-c]pyridi...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(NC(=O)c3ccccc3)cccc12
Show InChI InChI=1S/C33H28N6O3/c1-21-35-27-18-34-17-16-28(27)38(21)19-22-12-14-23(15-13-22)31(40)25-20-39(33(42)37(2)3)29-11-7-10-26(30(25)29)36-32(41)24-8-5-4-6-9-24/h4-18,20H,19H2,1-3H3,(H,36,41)
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2n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062042
PNG
(4-Methoxy-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-y...)
Show SMILES COc1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C27H25N5O3/c1-17-29-21-14-28-13-12-22(21)31(17)15-18-8-10-19(11-9-18)26(33)20-16-32(27(34)30(2)3)23-6-5-7-24(35-4)25(20)23/h5-14,16H,15H2,1-4H3
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2n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062095
PNG
(4-Methyl-3-{2-[4-(2-methyl-imidazo[4,5-c]pyridin-1...)
Show SMILES CN(C)C(=O)n1cc(C(=O)CN2CCC(CC2)n2c(C)nc3cnccc23)c2c(C)cccc12
Show InChI InChI=1S/C26H30N6O2/c1-17-6-5-7-23-25(17)20(15-31(23)26(34)29(3)4)24(33)16-30-12-9-19(10-13-30)32-18(2)28-21-14-27-11-8-22(21)32/h5-8,11,14-15,19H,9-10,12-13,16H2,1-4H3
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2n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062093
PNG
((4-Ethynyl-1H-indol-3-yl)-[3-fluoro-4-(2-methyl-im...)
Show SMILES Cc1nc2cnccc2n1Cc1ccc(cc1F)C(=O)c1c[nH]c2cccc(C#C)c12
Show InChI InChI=1S/C25H17FN4O/c1-3-16-5-4-6-21-24(16)19(12-28-21)25(31)17-7-8-18(20(26)11-17)14-30-15(2)29-22-13-27-10-9-23(22)30/h1,4-13,28H,14H2,2H3
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2.20n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Bromodomain testis-specific protein


(Homo sapiens (Human))
BDBM220447
PNG
(US9296741, 36)
Show SMILES CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H19F2N3O4S/c1-3-32(29,30)26-14-5-7-19(31-20-6-4-13(23)10-18(20)24)16(11-14)17-12-27(2)22(28)21-15(17)8-9-25-21/h4-12,25-26H,3H2,1-2H3
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2.20n/an/an/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of ADP-induced platelet aggregation in human platelet-rich plasma


J Med Chem 60: 8369-8384 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00746
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062112
PNG
(6-(4-Fluoro-phenyl)-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C32H26FN5O2/c1-20-35-28-17-34-15-14-29(28)37(20)18-21-4-6-23(7-5-21)31(39)27-19-38(32(40)36(2)3)30-16-24(10-13-26(27)30)22-8-11-25(33)12-9-22/h4-17,19H,18H2,1-3H3
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2.30n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
PTAFR


(RAT)
BDBM50286012
PNG
(3-{(R)-7-[1-Dimethylcarbamoyl-6-(4-fluoro-phenyl)-...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2ccc[n+]([O-])c2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H23FN4O3S/c1-31(2)29(36)34-16-24(22-10-7-19(14-25(22)34)18-5-8-21(30)9-6-18)27(35)23-11-13-33-26(23)17-38-28(33)20-4-3-12-32(37)15-20/h3-16,28H,17H2,1-2H3/t28-/m1/s1
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2.30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of platelet activating factor(PAF) by binding to PAF receptor


Bioorg Med Chem Lett 5: 2909-2912 (1995)


Article DOI: 10.1016/0960-894X(95)00510-Z
BindingDB Entry DOI: 10.7270/Q2S46RXM
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286012
PNG
(3-{(R)-7-[1-Dimethylcarbamoyl-6-(4-fluoro-phenyl)-...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2ccc[n+]([O-])c2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H23FN4O3S/c1-31(2)29(36)34-16-24(22-10-7-19(14-25(22)34)18-5-8-21(30)9-6-18)27(35)23-11-13-33-26(23)17-38-28(33)20-4-3-12-32(37)15-20/h3-16,28H,17H2,1-2H3/t28-/m1/s1
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2.30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
BRD4/HDAC1


(Homo sapiens (Human))
BDBM220415
PNG
(US9296741, 4)
Show SMILES Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H19N3O4S/c1-24-13-18(16-10-11-22-20(16)21(24)25)17-12-14(23-29(2,26)27)8-9-19(17)28-15-6-4-3-5-7-15/h3-13,22-23H,1-2H3
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2.40n/an/an/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of ADP-induced platelet aggregation in human platelet-rich plasma


J Med Chem 60: 8369-8384 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00746
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062071
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)C3CCC(Cn4c(C)nc5cnccc45)CC3)c12)C(=O)N(C)C |(5.2,-3.63,;5.2,-5.17,;3.88,-5.94,;2.54,-5.18,;3.88,-7.46,;2.55,-8.26,;2.55,-9.82,;3.88,-10.59,;5.23,-9.82,;6.71,-10.3,;7.63,-9.02,;6.71,-7.76,;7.18,-6.29,;6.41,-4.95,;8.71,-6.13,;9.75,-5.41,;11.56,-5.59,;11.95,-4.1,;12.85,-2.85,;14.38,-2.69,;15.47,-3.77,;15.24,-5.3,;16.83,-3.06,;16.57,-1.55,;17.53,-.36,;16.98,1.06,;15.46,1.3,;14.52,.11,;15.06,-1.31,;10.83,-4.82,;9.11,-4.64,;5.23,-8.26,;7.2,-11.75,;6.42,-13.08,;8.72,-11.91,;9.35,-13.31,;9.63,-10.67,)|
Show InChI InChI=1S/C28H31N5O4/c1-17-30-22-14-29-13-12-23(22)32(17)15-18-8-10-19(11-9-18)26(34)21-16-33(28(36)31(2)3)24-7-5-6-20(25(21)24)27(35)37-4/h5-7,12-14,16,18-19H,8-11,15H2,1-4H3
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2.40n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062127
PNG
(6-(4-Fluoro-phenyl)-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)N2CCC(Cn3c(C)nc4cnccc34)CC2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C31H31FN6O2/c1-20-34-27-17-33-13-10-28(27)37(20)18-21-11-14-36(15-12-21)30(39)26-19-38(31(40)35(2)3)29-16-23(6-9-25(26)29)22-4-7-24(32)8-5-22/h4-10,13,16-17,19,21H,11-12,14-15,18H2,1-3H3
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2.5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062102
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-b]p...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5ncccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H25N5O4/c1-17-30-26-23(9-6-14-29-26)32(17)15-18-10-12-19(13-11-18)25(34)21-16-33(28(36)31(2)3)22-8-5-7-20(24(21)22)27(35)37-4/h5-14,16H,15H2,1-4H3
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2.90n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50062067
PNG
(4-(4-Fluoro-phenyl)-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(cccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C32H26FN5O2/c1-20-35-27-17-34-16-15-28(27)37(20)18-21-7-9-23(10-8-21)31(39)26-19-38(32(40)36(2)3)29-6-4-5-25(30(26)29)22-11-13-24(33)14-12-22/h4-17,19H,18H2,1-3H3
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2.90n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes


J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
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