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Compile Data Set for Download or QSAR

Found 114 hits with Last Name = 'mantell' and Initial = 's'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor


(RAT)
BDBM50197275
PNG
(CHEMBL246023 | N-(2-(4-fluorophenyl)-2-methylpropy...)
Show SMILES CC(C)(CNC(=O)c1cnc2ccccc2n1)c1ccc(F)cc1
Show InChI InChI=1S/C19H18FN3O/c1-19(2,13-7-9-14(20)10-8-13)12-22-18(24)17-11-21-15-5-3-4-6-16(15)23-17/h3-11H,12H2,1-2H3,(H,22,24)
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2n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197248
PNG
(CHEMBL246244 | N-(2-methyl-2-phenylpropyl)-5,6,7,8...)
Show SMILES CC(C)(CNC(=O)c1cnc2CCCCc2n1)c1ccccc1
Show InChI InChI=1S/C19H23N3O/c1-19(2,14-8-4-3-5-9-14)13-21-18(23)17-12-20-15-10-6-7-11-16(15)22-17/h3-5,8-9,12H,6-7,10-11,13H2,1-2H3,(H,21,23)
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2n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278288
PNG
(2-(2-(4-(2,3-dihydro-1H-inden-2-ylamino)pyrido[3,4...)
Show SMILES OCCOCCNc1cc2c(NC3Cc4ccccc4C3)ncnc2cn1
Show InChI InChI=1S/C20H23N5O2/c26-6-8-27-7-5-21-19-11-17-18(12-22-19)23-13-24-20(17)25-16-9-14-3-1-2-4-15(14)10-16/h1-4,11-13,16,26H,5-10H2,(H,21,22)(H,23,24,25)
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3n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197249
PNG
(CHEMBL245819 | N-(2-methyl-2-phenylpropyl)quinoxal...)
Show SMILES CC(C)(CNC(=O)c1cnc2ccccc2n1)c1ccccc1
Show InChI InChI=1S/C19H19N3O/c1-19(2,14-8-4-3-5-9-14)13-21-18(23)17-12-20-15-10-6-7-11-16(15)22-17/h3-12H,13H2,1-2H3,(H,21,23)
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3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197254
PNG
(CHEMBL246250 | N-((1r,4r)-4-methylcyclohexyl)-5-(p...)
Show SMILES C[C@H]1CC[C@@H](CC1)NC(=O)c1cnc(cn1)N1CCCCC1 |wU:4.7,wD:1.0,(7.01,-30.31,;5.68,-31.07,;4.34,-30.31,;3.01,-31.08,;3.02,-32.61,;4.35,-33.38,;5.68,-32.61,;1.69,-33.39,;.35,-32.62,;.35,-31.08,;-.98,-33.4,;-.97,-34.95,;-2.31,-35.72,;-3.64,-34.95,;-3.64,-33.4,;-2.31,-32.63,;-4.97,-35.72,;-6.31,-34.95,;-7.64,-35.71,;-7.65,-37.25,;-6.31,-38.02,;-4.97,-37.26,)|
Show InChI InChI=1S/C17H26N4O/c1-13-5-7-14(8-6-13)20-17(22)15-11-19-16(12-18-15)21-9-3-2-4-10-21/h11-14H,2-10H2,1H3,(H,20,22)/t13-,14-
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3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278286
PNG
(CHEMBL511266 | N4-(2,3-dihydro-1H-inden-2-yl)-N6-(...)
Show SMILES COCCNc1cc2c(NC3Cc4ccccc4C3)ncnc2cn1
Show InChI InChI=1S/C19H21N5O/c1-25-7-6-20-18-10-16-17(11-21-18)22-12-23-19(16)24-15-8-13-4-2-3-5-14(13)9-15/h2-5,10-12,15H,6-9H2,1H3,(H,20,21)(H,22,23,24)
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5n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278407
PNG
(CHEMBL470396 | N-cycloheptyl-6-(2-morpholinoethoxy...)
Show SMILES C(CN1CCOCC1)Oc1cc2c(NC3CCCCCC3)ncnc2cn1
Show InChI InChI=1S/C20H29N5O2/c1-2-4-6-16(5-3-1)24-20-17-13-19(21-14-18(17)22-15-23-20)27-12-9-25-7-10-26-11-8-25/h13-16H,1-12H2,(H,22,23,24)
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6n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197247
PNG
(CHEMBL246251 | N-cycloheptyl-5-(piperidin-1-yl)pyr...)
Show SMILES O=C(NC1CCCCCC1)c1cnc(cn1)N1CCCCC1
Show InChI InChI=1S/C17H26N4O/c22-17(20-14-8-4-1-2-5-9-14)15-12-19-16(13-18-15)21-10-6-3-7-11-21/h12-14H,1-11H2,(H,20,22)
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8n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197268
PNG
(5-(4-(hydroxymethyl)piperidin-1-yl)-N-((1r,4r)-4-m...)
Show SMILES C[C@H]1CC[C@@H](CC1)NC(=O)c1cnc(cn1)N1CCC(CO)CC1 |wU:4.7,wD:1.0,(9.04,-40.15,;7.71,-40.92,;6.38,-40.15,;5.04,-40.92,;5.05,-42.45,;6.38,-43.22,;7.71,-42.46,;3.72,-43.23,;2.38,-42.46,;2.38,-40.92,;1.05,-43.24,;1.06,-44.79,;-.28,-45.56,;-1.61,-44.79,;-1.61,-43.25,;-.28,-42.48,;-2.95,-45.56,;-4.28,-44.79,;-5.61,-45.55,;-5.62,-47.09,;-6.96,-47.85,;-8.29,-47.08,;-4.29,-47.87,;-2.94,-47.1,)|
Show InChI InChI=1S/C18H28N4O2/c1-13-2-4-15(5-3-13)21-18(24)16-10-20-17(11-19-16)22-8-6-14(12-23)7-9-22/h10-11,13-15,23H,2-9,12H2,1H3,(H,21,24)/t13-,15-
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9n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278361
PNG
(CHEMBL471435 | N4-cyclohexyl-N6-(2-morpholinoethyl...)
Show SMILES C(CN1CCOCC1)Nc1cc2c(NC3CCCCC3)ncnc2cn1
Show InChI InChI=1S/C19H28N6O/c1-2-4-15(5-3-1)24-19-16-12-18(21-13-17(16)22-14-23-19)20-6-7-25-8-10-26-11-9-25/h12-15H,1-11H2,(H,20,21)(H,22,23,24)
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10n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278289
PNG
(CHEMBL469383 | N4-cyclohexyl-N6-(2-methoxyethyl)py...)
Show SMILES COCCNc1cc2c(NC3CCCCC3)ncnc2cn1
Show InChI InChI=1S/C16H23N5O/c1-22-8-7-17-15-9-13-14(10-18-15)19-11-20-16(13)21-12-5-3-2-4-6-12/h9-12H,2-8H2,1H3,(H,17,18)(H,19,20,21)
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11n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197272
PNG
(CHEMBL246245 | N-(2-methyl-2-phenylpropyl)-6-(pipe...)
Show SMILES CC(C)(CNC(=O)c1cncc(n1)N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C20H26N4O/c1-20(2,16-9-5-3-6-10-16)15-22-19(25)17-13-21-14-18(23-17)24-11-7-4-8-12-24/h3,5-6,9-10,13-14H,4,7-8,11-12,15H2,1-2H3,(H,22,25)
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11n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197276
PNG
(5-((2-cyanoethyl)(methyl)amino)-N-(2-methyl-2-phen...)
Show SMILES CN(CCC#N)c1cnc(cn1)C(=O)NCC(C)(C)c1ccccc1
Show InChI InChI=1S/C19H23N5O/c1-19(2,15-8-5-4-6-9-15)14-23-18(25)16-12-22-17(13-21-16)24(3)11-7-10-20/h4-6,8-9,12-13H,7,11,14H2,1-3H3,(H,23,25)
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14n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278112
PNG
(CHEMBL472490 | N4-(2,3-dihydro-1H-inden-2-yl)-N6-m...)
Show SMILES CNc1cc2c(NC3Cc4ccccc4C3)ncnc2cn1
Show InChI InChI=1S/C17H17N5/c1-18-16-8-14-15(9-19-16)20-10-21-17(14)22-13-6-11-4-2-3-5-12(11)7-13/h2-5,8-10,13H,6-7H2,1H3,(H,18,19)(H,20,21,22)
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14n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197266
PNG
(CHEMBL246024 | N-(2-methoxy-2-phenylpropyl)quinoxa...)
Show SMILES COC(C)(CNC(=O)c1cnc2ccccc2n1)c1ccccc1 |w:2.2|
Show InChI InChI=1S/C19H19N3O2/c1-19(24-2,14-8-4-3-5-9-14)13-21-18(23)17-12-20-15-10-6-7-11-16(15)22-17/h3-12H,13H2,1-2H3,(H,21,23)
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15n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197255
PNG
(CHEMBL443489 | N-(2-methyl-2-phenylpropyl)-5-(pipe...)
Show SMILES CC(C)(CNC(=O)c1cnc(cn1)N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C20H26N4O/c1-20(2,16-9-5-3-6-10-16)15-23-19(25)17-13-22-18(14-21-17)24-11-7-4-8-12-24/h3,5-6,9-10,13-14H,4,7-8,11-12,15H2,1-2H3,(H,23,25)
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17n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278358
PNG
(1-(2-(4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-6-...)
Show SMILES O=C1CCCN1CCOc1cc2c(NC3CCCCC3)ncnc2cn1
Show InChI InChI=1S/C19H25N5O2/c25-18-7-4-8-24(18)9-10-26-17-11-15-16(12-20-17)21-13-22-19(15)23-14-5-2-1-3-6-14/h11-14H,1-10H2,(H,21,22,23)
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20n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278232
PNG
(2-(4-(2,3-dihydro-1H-inden-2-ylamino)pyrido[3,4-d]...)
Show SMILES OCCNc1cc2c(NC3Cc4ccccc4C3)ncnc2cn1
Show InChI InChI=1S/C18H19N5O/c24-6-5-19-17-9-15-16(10-20-17)21-11-22-18(15)23-14-7-12-3-1-2-4-13(12)8-14/h1-4,9-11,14,24H,5-8H2,(H,19,20)(H,21,22,23)
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21n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197265
PNG
(CHEMBL241699 | N-(2-phenylpropyl)quinoxaline-2-car...)
Show SMILES CC(CNC(=O)c1cnc2ccccc2n1)c1ccccc1 |w:1.0|
Show InChI InChI=1S/C18H17N3O/c1-13(14-7-3-2-4-8-14)11-20-18(22)17-12-19-15-9-5-6-10-16(15)21-17/h2-10,12-13H,11H2,1H3,(H,20,22)
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22n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197270
PNG
((R)-6-(2-hydroxy-1-phenylethylamino)-N-(2-methyl-2...)
Show SMILES CC(C)(CNC(=O)c1cncc(N[C@@H](CO)c2ccccc2)n1)c1ccccc1
Show InChI InChI=1S/C23H26N4O2/c1-23(2,18-11-7-4-8-12-18)16-25-22(29)19-13-24-14-21(26-19)27-20(15-28)17-9-5-3-6-10-17/h3-14,20,28H,15-16H2,1-2H3,(H,25,29)(H,26,27)/t20-/m0/s1
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27n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197257
PNG
(5-((1-(dimethylamino)propan-2-yl)(methyl)amino)-N-...)
Show SMILES CC(CN(C)C)N(C)c1cnc(cn1)C(=O)NCC(C)(C)c1ccccc1 |w:1.0|
Show InChI InChI=1S/C21H31N5O/c1-16(14-25(4)5)26(6)19-13-22-18(12-23-19)20(27)24-15-21(2,3)17-10-8-7-9-11-17/h7-13,16H,14-15H2,1-6H3,(H,24,27)
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27n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278114
PNG
(CHEMBL513012 | N-cyclohexylquinazolin-4-amine)
Show SMILES C1CCC(CC1)Nc1ncnc2ccccc12
Show InChI InChI=1S/C14H17N3/c1-2-6-11(7-3-1)17-14-12-8-4-5-9-13(12)15-10-16-14/h4-5,8-11H,1-3,6-7H2,(H,15,16,17)
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27n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197251
PNG
(6-(butyl(methyl)amino)-N-cycloheptylpyrazine-2-car...)
Show SMILES CCCCN(C)c1cncc(n1)C(=O)NC1CCCCCC1
Show InChI InChI=1S/C17H28N4O/c1-3-4-11-21(2)16-13-18-12-15(20-16)17(22)19-14-9-7-5-6-8-10-14/h12-14H,3-11H2,1-2H3,(H,19,22)
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30n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278231
PNG
(CHEMBL513018 | N4,N6-bis(2,3-dihydro-1H-inden-2-yl...)
Show SMILES C1C(Cc2ccccc12)Nc1cc2c(NC3Cc4ccccc4C3)ncnc2cn1
Show InChI InChI=1S/C25H23N5/c1-2-6-17-10-20(9-16(17)5-1)29-24-13-22-23(14-26-24)27-15-28-25(22)30-21-11-18-7-3-4-8-19(18)12-21/h1-8,13-15,20-21H,9-12H2,(H,26,29)(H,27,28,30)
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31n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278357
PNG
(3-(4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-6-ylo...)
Show SMILES OCCCOc1cc2c(NC3CCCCC3)ncnc2cn1
Show InChI InChI=1S/C16H22N4O2/c21-7-4-8-22-15-9-13-14(10-17-15)18-11-19-16(13)20-12-5-2-1-3-6-12/h9-12,21H,1-8H2,(H,18,19,20)
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33n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278153
PNG
(CHEMBL471242 | N-(2,3-dihydro-1H-inden-2-yl)quinaz...)
Show SMILES C1C(Cc2ccccc12)Nc1ncnc2ccccc12
Show InChI InChI=1S/C17H15N3/c1-2-6-13-10-14(9-12(13)5-1)20-17-15-7-3-4-8-16(15)18-11-19-17/h1-8,11,14H,9-10H2,(H,18,19,20)
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34n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197264
PNG
(5-(4-(hydroxymethyl)piperidin-1-yl)-N-(2-methyl-2-...)
Show SMILES CC(C)(CNC(=O)c1cnc(cn1)N1CCC(CO)CC1)c1ccccc1
Show InChI InChI=1S/C21H28N4O2/c1-21(2,17-6-4-3-5-7-17)15-24-20(27)18-12-23-19(13-22-18)25-10-8-16(14-26)9-11-25/h3-7,12-13,16,26H,8-11,14-15H2,1-2H3,(H,24,27)
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35n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197262
PNG
(CHEMBL246025 | N-(2-methyl-2-(pyridin-2-yl)propyl)...)
Show SMILES CC(C)(CNC(=O)c1cnc2ccccc2n1)c1ccccn1
Show InChI InChI=1S/C18H18N4O/c1-18(2,16-9-5-6-10-19-16)12-21-17(23)15-11-20-13-7-3-4-8-14(13)22-15/h3-11H,12H2,1-2H3,(H,21,23)
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40n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197245
PNG
(CHEMBL393681 | N-(2-methyl-1-phenylpropan-2-yl)qui...)
Show SMILES CC(C)(Cc1ccccc1)NC(=O)c1cnc2ccccc2n1
Show InChI InChI=1S/C19H19N3O/c1-19(2,12-14-8-4-3-5-9-14)22-18(23)17-13-20-15-10-6-7-11-16(15)21-17/h3-11,13H,12H2,1-2H3,(H,22,23)
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40n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197252
PNG
(CHEMBL247485 | N-(2,3-dihydro-1H-inden-2-yl)-6-(et...)
Show SMILES CCN(C)c1cncc(n1)C(=O)NC1Cc2ccccc2C1
Show InChI InChI=1S/C17H20N4O/c1-3-21(2)16-11-18-10-15(20-16)17(22)19-14-8-12-6-4-5-7-13(12)9-14/h4-7,10-11,14H,3,8-9H2,1-2H3,(H,19,22)
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40n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278362
PNG
(CHEMBL512523 | N-cyclohexyl-6-(2-morpholinoethoxy)...)
Show SMILES C(CN1CCOCC1)Oc1cc2c(NC3CCCCC3)ncnc2cn1
Show InChI InChI=1S/C19H27N5O2/c1-2-4-15(5-3-1)23-19-16-12-18(20-13-17(16)21-14-22-19)26-11-8-24-6-9-25-10-7-24/h12-15H,1-11H2,(H,21,22,23)
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42n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197267
PNG
(6-((2-hydroxyethyl)(methyl)amino)-N-(2-methyl-2-ph...)
Show SMILES CN(CCO)c1cncc(n1)C(=O)NCC(C)(C)c1ccccc1
Show InChI InChI=1S/C18H24N4O2/c1-18(2,14-7-5-4-6-8-14)13-20-17(24)15-11-19-12-16(21-15)22(3)9-10-23/h4-8,11-12,23H,9-10,13H2,1-3H3,(H,20,24)
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43n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197253
PNG
(6-(3-hydroxyphenethylamino)-N-(cyclopropylmethyl)p...)
Show SMILES Oc1cccc(CCNc2cncc(n2)C(=O)NCC2CC2)c1
Show InChI InChI=1S/C17H20N4O2/c22-14-3-1-2-12(8-14)6-7-19-16-11-18-10-15(21-16)17(23)20-9-13-4-5-13/h1-3,8,10-11,13,22H,4-7,9H2,(H,19,21)(H,20,23)
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44n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278111
PNG
(CHEMBL472489 | N4-(2,3-dihydro-1H-inden-2-yl)-N4,N...)
Show SMILES CNc1cc2c(ncnc2cn1)N(C)C1Cc2ccccc2C1
Show InChI InChI=1S/C18H19N5/c1-19-17-9-15-16(10-20-17)21-11-22-18(15)23(2)14-7-12-5-3-4-6-13(12)8-14/h3-6,9-11,14H,7-8H2,1-2H3,(H,19,20)
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54n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197259
PNG
(6-(4-benzyl-1,4-diazepan-1-yl)-N-(cyclopropylmethy...)
Show SMILES O=C(NCC1CC1)c1cncc(n1)N1CCCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H27N5O/c27-21(23-13-17-7-8-17)19-14-22-15-20(24-19)26-10-4-9-25(11-12-26)16-18-5-2-1-3-6-18/h1-3,5-6,14-15,17H,4,7-13,16H2,(H,23,27)
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56n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197271
PNG
(CHEMBL245820 | N-phenethylquinoxaline-2-carboxamid...)
Show SMILES O=C(NCCc1ccccc1)c1cnc2ccccc2n1
Show InChI InChI=1S/C17H15N3O/c21-17(18-11-10-13-6-2-1-3-7-13)16-12-19-14-8-4-5-9-15(14)20-16/h1-9,12H,10-11H2,(H,18,21)
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69n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278291
PNG
(CHEMBL471666 | N-cyclohexyl-6-(2-methoxyethoxy)pyr...)
Show SMILES COCCOc1cc2c(NC3CCCCC3)ncnc2cn1
Show InChI InChI=1S/C16H22N4O2/c1-21-7-8-22-15-9-13-14(10-17-15)18-11-19-16(13)20-12-5-3-2-4-6-12/h9-12H,2-8H2,1H3,(H,18,19,20)
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101n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278287
PNG
(CHEMBL469381 | N4-(2,3-dihydro-1H-inden-2-yl)-N6-(...)
Show SMILES CN(C)CCNc1cc2c(NC3Cc4ccccc4C3)ncnc2cn1
Show InChI InChI=1S/C20H24N6/c1-26(2)8-7-21-19-11-17-18(12-22-19)23-13-24-20(17)25-16-9-14-5-3-4-6-15(14)10-16/h3-6,11-13,16H,7-10H2,1-2H3,(H,21,22)(H,23,24,25)
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102n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278113
PNG
(CHEMBL513761 | N-(2,3-dihydro-1H-inden-2-yl)-6-met...)
Show SMILES COc1cc2c(NC3Cc4ccccc4C3)ncnc2cn1
Show InChI InChI=1S/C17H16N4O/c1-22-16-8-14-15(9-18-16)19-10-20-17(14)21-13-6-11-4-2-3-5-12(11)7-13/h2-5,8-10,13H,6-7H2,1H3,(H,19,20,21)
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115n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278229
PNG
(2-(6-(2,3-dihydro-1H-inden-2-ylamino)pyrido[3,4-d]...)
Show SMILES OCCNc1ncnc2cnc(NC3Cc4ccccc4C3)cc12
Show InChI InChI=1S/C18H19N5O/c24-6-5-19-18-15-9-17(20-10-16(15)21-11-22-18)23-14-7-12-3-1-2-4-13(12)8-14/h1-4,9-11,14,24H,5-8H2,(H,20,23)(H,19,21,22)
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125n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197273
PNG
((3-phenylpiperidin-1-yl)(quinoxalin-2-yl)methanone...)
Show SMILES O=C(N1CCCC(C1)c1ccccc1)c1cnc2ccccc2n1 |w:6.8|
Show InChI InChI=1S/C20H19N3O/c24-20(19-13-21-17-10-4-5-11-18(17)22-19)23-12-6-9-16(14-23)15-7-2-1-3-8-15/h1-5,7-8,10-11,13,16H,6,9,12,14H2
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125n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278228
PNG
(CHEMBL447113 | N6-(2,3-dihydro-1H-inden-2-yl)-N4-m...)
Show SMILES CNc1ncnc2cnc(NC3Cc4ccccc4C3)cc12
Show InChI InChI=1S/C17H17N5/c1-18-17-14-8-16(19-9-15(14)20-10-21-17)22-13-6-11-4-2-3-5-12(11)7-13/h2-5,8-10,13H,6-7H2,1H3,(H,19,22)(H,18,20,21)
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160n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278290
PNG
(2-(4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-6-ylo...)
Show SMILES OCCOc1cc2c(NC3CCCCC3)ncnc2cn1
Show InChI InChI=1S/C15H20N4O2/c20-6-7-21-14-8-12-13(9-16-14)17-10-18-15(12)19-11-4-2-1-3-5-11/h8-11,20H,1-7H2,(H,17,18,19)
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177n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197258
PNG
(CHEMBL247476 | N-(2-methyl-2-phenylpropyl)-5-pheny...)
Show SMILES CC(C)(CNC(=O)c1cnc(cn1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H21N3O/c1-21(2,17-11-7-4-8-12-17)15-24-20(25)19-14-22-18(13-23-19)16-9-5-3-6-10-16/h3-14H,15H2,1-2H3,(H,24,25)
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179n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278853
PNG
(CHEMBL496897 | N4-(2,3-dihydro-1H-inden-2-yl)-N6,N...)
Show SMILES CN(C)c1cc2c(NC3Cc4ccccc4C3)ncnc2cn1
Show InChI InChI=1S/C18H19N5/c1-23(2)17-9-15-16(10-19-17)20-11-21-18(15)22-14-7-12-5-3-4-6-13(12)8-14/h3-6,9-11,14H,7-8H2,1-2H3,(H,20,21,22)
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185n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278850
PNG
(CHEMBL497918 | N4-cyclohexyl-N6,N6-dimethylpyrido[...)
Show SMILES CN(C)c1cc2c(NC3CCCCC3)ncnc2cn1
Show InChI InChI=1S/C15H21N5/c1-20(2)14-8-12-13(9-16-14)17-10-18-15(12)19-11-6-4-3-5-7-11/h8-11H,3-7H2,1-2H3,(H,17,18,19)
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199n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278360
PNG
(CHEMBL471434 | N6-(3-aminopropyl)-N4-cyclohexylpyr...)
Show SMILES NCCCNc1cc2c(NC3CCCCC3)ncnc2cn1
Show InChI InChI=1S/C16H24N6/c17-7-4-8-18-15-9-13-14(10-19-15)20-11-21-16(13)22-12-5-2-1-3-6-12/h9-12H,1-8,17H2,(H,18,19)(H,20,21,22)
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200n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50278110
PNG
(CHEMBL511838 | N4-(2,3-dihydro-1H-inden-2-yl)-N4,N...)
Show SMILES CN(C)c1cc2c(ncnc2cn1)N(C)C1Cc2ccccc2C1
Show InChI InChI=1S/C19H21N5/c1-23(2)18-10-16-17(11-20-18)21-12-22-19(16)24(3)15-8-13-6-4-5-7-14(13)9-15/h4-7,10-12,15H,8-9H2,1-3H3
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300n/an/an/an/an/an/an/an/a



Medical Research Council Technology

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...


Bioorg Med Chem Lett 19: 2190-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.106
BindingDB Entry DOI: 10.7270/Q2057FSP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197269
PNG
(CHEMBL247475 | N-(2-methyl-2-phenylpropyl)-6-pheny...)
Show SMILES CC(C)(CNC(=O)c1cncc(n1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H21N3O/c1-21(2,17-11-7-4-8-12-17)15-23-20(25)19-14-22-13-18(24-19)16-9-5-3-6-10-16/h3-14H,15H2,1-2H3,(H,23,25)
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315n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50197274
PNG
((8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-2...)
Show SMILES CN1CCN(CC1)c1nccn2cc(nc12)C(=O)N1CCCN(CC1)c1ccccn1
Show InChI InChI=1S/C22H28N8O/c1-26-11-13-28(14-12-26)20-21-25-18(17-30(21)10-7-24-20)22(31)29-9-4-8-27(15-16-29)19-5-2-3-6-23-19/h2-3,5-7,10,17H,4,8-9,11-16H2,1H3
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407n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assay


Bioorg Med Chem Lett 17: 486-90 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.015
BindingDB Entry DOI: 10.7270/Q2VX0G5Q
More data for this
Ligand-Target Pair
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