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Compile Data Set for Download or QSAR

Found 121 hits with Last Name = 'marlin' and Initial = 'fj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140390
PNG
(US8912173, 115 | US9914735, Example 115)
Show SMILES CC(C)n1cc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1/C21H24N4O2/c1-13(2)25-12-17(11-24-25)15-7-19-18(5-4-6-22-19)20(8-15)27-14(3)16-9-21(26)23-10-16/h4-8,11-14,16H,9-10H2,1-3H3,(H,23,26)/t14-,16-/s2
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n/an/a 0n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140389
PNG
(US8912173, 114 | US9914735, Example 114)
Show SMILES CCCn1cc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1/C21H24N4O2/c1-3-7-25-13-17(12-24-25)15-8-19-18(5-4-6-22-19)20(9-15)27-14(2)16-10-21(26)23-11-16/h4-6,8-9,12-14,16H,3,7,10-11H2,1-2H3,(H,23,26)/t14-,16-/s2
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n/an/a 0n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140325
PNG
(US8912173, 51)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(CN(C)C(C)=O)cc1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C25H27N3O3/c1-16(21-13-25(30)27-14-21)31-24-12-20(11-23-22(24)5-4-10-26-23)19-8-6-18(7-9-19)15-28(3)17(2)29/h4-12,16,21H,13-15H2,1-3H3,(H,27,30)/t16-,21-/s2
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n/an/a 0n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140322
PNG
(US8912173, 48)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(nc1)N1CCOCC1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C24H26N4O3/c1-16(19-13-24(29)27-15-19)31-22-12-18(11-21-20(22)3-2-6-25-21)17-4-5-23(26-14-17)28-7-9-30-10-8-28/h2-6,11-12,14,16,19H,7-10,13,15H2,1H3,(H,27,29)/t16-,19-/s2
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n/an/a 0.100n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140394
PNG
(US8912173, 119)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1cnn(CCOC(C)=O)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C22H24N4O4/c1-14(17-10-22(28)24-11-17)30-21-9-16(8-20-19(21)4-3-5-23-20)18-12-25-26(13-18)6-7-29-15(2)27/h3-5,8-9,12-14,17H,6-7,10-11H2,1-2H3,(H,24,28)/t14-,17-/s2
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n/an/a 0.100n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140337
PNG
(US8912173, 63)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2NC(=O)OCc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C23H21N3O4/c1-13(16-10-22(27)25-11-16)30-21-9-15(8-20-18(21)3-2-6-24-20)14-4-5-19-17(7-14)12-29-23(28)26-19/h2-9,13,16H,10-12H2,1H3,(H,25,27)(H,26,28)/t13-,16-/s2
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n/an/a 0.100n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140393
PNG
(US8912173, 118)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1cnn(CCO)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C20H22N4O3/c1-13(15-9-20(26)22-10-15)27-19-8-14(7-18-17(19)3-2-4-21-18)16-11-23-24(12-16)5-6-25/h2-4,7-8,11-13,15,25H,5-6,9-10H2,1H3,(H,22,26)/t13-,15-/s2
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n/an/a 0.100n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140353
PNG
(US8912173, 78)
Show SMILES CCn1cc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1/C20H22N4O2/c1-3-24-12-16(11-23-24)14-7-18-17(5-4-6-21-18)19(8-14)26-13(2)15-9-20(25)22-10-15/h4-8,11-13,15H,3,9-10H2,1-2H3,(H,22,25)/t13-,15-/s2
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n/an/a 0.200n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140360
PNG
(US8912173, 85 | US9914735, Example 85)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2nc(C)sc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C23H21N3O2S/c1-13(17-11-23(27)25-12-17)28-21-9-16(8-20-18(21)4-3-7-24-20)15-5-6-19-22(10-15)29-14(2)26-19/h3-10,13,17H,11-12H2,1-2H3,(H,25,27)/t13-,17-/s2
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n/an/a 0.200n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140361
PNG
(US8912173, 86)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(c(Cl)c1)C1(N)CC1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C24H24ClN3O2/c1-14(17-12-23(29)28-13-17)30-22-11-16(10-21-18(22)3-2-8-27-21)15-4-5-19(20(25)9-15)24(26)6-7-24/h2-5,8-11,14,17H,6-7,12-13,26H2,1H3,(H,28,29)/t14-,17-/s2
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n/an/a 0.200n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140380
PNG
(US8912173, 105 | US9914735, Example 105)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2n(C)c(C)nc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C24H24N4O2/c1-14(18-12-24(29)26-13-18)30-23-11-17(10-20-19(23)5-4-8-25-20)16-6-7-22-21(9-16)27-15(2)28(22)3/h4-11,14,18H,12-13H2,1-3H3,(H,26,29)/t14-,18-/s2
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n/an/a 0.200n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140321
PNG
(US8912173, 47)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1cnn(C)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C19H20N4O2/c1-12(14-8-19(24)21-9-14)25-18-7-13(15-10-22-23(2)11-15)6-17-16(18)4-3-5-20-17/h3-7,10-12,14H,8-9H2,1-2H3,(H,21,24)/t12-,14-/s2
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n/an/a 0.200n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140342
PNG
(US8912173, 68)
Show SMILES CCN(Cc1ccc(cc1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1)C(C)=O |r|
Show InChI InChI=1/C26H29N3O3/c1-4-29(18(3)30)16-19-7-9-20(10-8-19)21-12-24-23(6-5-11-27-24)25(13-21)32-17(2)22-14-26(31)28-15-22/h5-13,17,22H,4,14-16H2,1-3H3,(H,28,31)/t17-,22-/s2
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n/an/a 0.200n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140315
PNG
(US8912173, 41)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2[nH]cnc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C22H20N4O2/c1-13(16-10-22(27)24-11-16)28-21-9-15(8-19-17(21)3-2-6-23-19)14-4-5-18-20(7-14)26-12-25-18/h2-9,12-13,16H,10-11H2,1H3,(H,24,27)(H,25,26)/t13-,16-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140363
PNG
(US8912173, 88)
Show SMILES COc1ccc(nc1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1/C21H21N3O3/c1-13(15-10-21(25)24-11-15)27-20-9-14(8-19-17(20)4-3-7-22-19)18-6-5-16(26-2)12-23-18/h3-9,12-13,15H,10-11H2,1-2H3,(H,24,25)/t13-,15-/s2
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n/an/a 0.300n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140329
PNG
(US8912173, 55)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(CN2CCCCC2=O)cc1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C27H29N3O3/c1-18(22-15-26(31)29-16-22)33-25-14-21(13-24-23(25)5-4-11-28-24)20-9-7-19(8-10-20)17-30-12-3-2-6-27(30)32/h4-5,7-11,13-14,18,22H,2-3,6,12,15-17H2,1H3,(H,29,31)/t18-,22-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140343
PNG
(US8912173, 69)
Show SMILES CCOc1ccc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1/C22H23N3O3/c1-3-27-22-7-6-15(12-25-22)16-9-19-18(5-4-8-23-19)20(10-16)28-14(2)17-11-21(26)24-13-17/h4-10,12,14,17H,3,11,13H2,1-2H3,(H,24,26)/t14-,17-/s2
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n/an/a 0.300n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140369
PNG
(US8912173, 94 | US9914735, Example 94)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2n(C)cnc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C23H22N4O2/c1-14(17-11-23(28)25-12-17)29-22-10-16(9-19-18(22)4-3-7-24-19)15-5-6-21-20(8-15)26-13-27(21)2/h3-10,13-14,17H,11-12H2,1-2H3,(H,25,28)/t14-,17-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140303
PNG
(US8912173, 29)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2ncccc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C24H21N3O2/c1-15(19-13-24(28)27-14-19)29-23-12-18(11-22-20(23)5-3-9-26-22)16-6-7-21-17(10-16)4-2-8-25-21/h2-12,15,19H,13-14H2,1H3,(H,27,28)/t15-,19-/s2
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n/an/a 0.300n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140317
PNG
(US8912173, 43)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(CN2CCOCC2)cc1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C26H29N3O3/c1-18(22-15-26(30)28-16-22)32-25-14-21(13-24-23(25)3-2-8-27-24)20-6-4-19(5-7-20)17-29-9-11-31-12-10-29/h2-8,13-14,18,22H,9-12,15-17H2,1H3,(H,28,30)/t18-,22-/s2
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n/an/a 0.300n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140376
PNG
(US8912173, 101 | US9914735, Example 101)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2CCNCc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C24H25N3O2/c1-15(19-12-24(28)27-14-19)29-23-11-18(10-22-21(23)3-2-7-26-22)17-5-4-16-6-8-25-13-20(16)9-17/h2-5,7,9-11,15,19,25H,6,8,12-14H2,1H3,(H,27,28)/t15-,19-/s2
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n/an/a 0.400n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140384
PNG
(US8912173, 109 | US9914735, Example 109)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2[nH]c(C)nc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C23H22N4O2/c1-13(17-11-23(28)25-12-17)29-22-10-16(9-20-18(22)4-3-7-24-20)15-5-6-19-21(8-15)27-14(2)26-19/h3-10,13,17H,11-12H2,1-2H3,(H,25,28)(H,26,27)/t13-,17-/s2
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n/an/a 0.400n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140276
PNG
(US8912173, 2)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1/C24H26N2O5/c1-14(17-12-23(27)26-13-17)31-20-9-15(8-19-18(20)6-5-7-25-19)16-10-21(28-2)24(30-4)22(11-16)29-3/h5-11,14,17H,12-13H2,1-4H3,(H,26,27)/t14-,17-/s2
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n/an/a 0.400n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140284
PNG
(US8912173, 10)
Show SMILES COc1cc(ccc1OC(C)C)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1/C25H28N2O4/c1-15(2)30-22-8-7-17(11-24(22)29-4)18-10-21-20(6-5-9-26-21)23(12-18)31-16(3)19-13-25(28)27-14-19/h5-12,15-16,19H,13-14H2,1-4H3,(H,27,28)/t16-,19-/s2
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n/an/a 0.400n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140308
PNG
(US8912173, 34)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2ccccc2n1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C24H21N3O2/c1-15(18-13-24(28)26-14-18)29-23-12-17(11-22-19(23)6-4-10-25-22)21-9-8-16-5-2-3-7-20(16)27-21/h2-12,15,18H,13-14H2,1H3,(H,26,28)/t15-,18-/s2
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n/an/a 0.400n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140368
PNG
(US8912173, 93)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2[nH]c(nc2c1)C(F)(F)F)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C23H19F3N4O2/c1-12(15-10-21(31)28-11-15)32-20-9-14(8-18-16(20)3-2-6-27-18)13-4-5-17-19(7-13)30-22(29-17)23(24,25)26/h2-9,12,15H,10-11H2,1H3,(H,28,31)(H,29,30)/t12-,15-/s2
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n/an/a 0.400n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140336
PNG
(US8912173, 62)
Show SMILES NC(=O)c1cccnc1COc1cc(cc2ncccc12)-c1ccc(c(Cl)c1)C1(N)CC1
Show InChI InChI=1S/C25H21ClN4O2/c26-20-11-15(5-6-19(20)25(28)7-8-25)16-12-21-17(3-1-9-29-21)23(13-16)32-14-22-18(24(27)31)4-2-10-30-22/h1-6,9-13H,7-8,14,28H2,(H2,27,31)
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n/an/a 0.400n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140275
PNG
(US8912173, 1)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccccc1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C21H20N2O2/c1-14(17-12-21(24)23-13-17)25-20-11-16(15-6-3-2-4-7-15)10-19-18(20)8-5-9-22-19/h2-11,14,17H,12-13H2,1H3,(H,23,24)/t14-,17-/s2
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n/an/a 0.400n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140323
PNG
(US8912173, 49)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(cn1)C(F)(F)F)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C21H18F3N3O2/c1-12(14-9-20(28)27-10-14)29-19-8-13(7-18-16(19)3-2-6-25-18)17-5-4-15(11-26-17)21(22,23)24/h2-8,11-12,14H,9-10H2,1H3,(H,27,28)/t12-,14-/s2
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n/an/a 0.5n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140388
PNG
(US8912173, 113)
Show SMILES CC(C)n1cc(cn1)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1
Show InChI InChI=1S/C22H21N5O2/c1-14(2)27-12-16(11-26-27)15-9-19-17(5-3-7-24-19)21(10-15)29-13-20-18(22(23)28)6-4-8-25-20/h3-12,14H,13H2,1-2H3,(H2,23,28)
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n/an/a 0.5n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140299
PNG
(US8912173, 25)
Show SMILES COc1ccc(cc1OC)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1
Show InChI InChI=1S/C24H21N3O4/c1-29-21-8-7-15(12-23(21)30-2)16-11-19-17(5-3-9-26-19)22(13-16)31-14-20-18(24(25)28)6-4-10-27-20/h3-13H,14H2,1-2H3,(H2,25,28)
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n/an/a 0.600n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140285
PNG
(US8912173, 11)
Show SMILES COc1cc(ccc1O)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1/C22H22N2O4/c1-13(16-11-22(26)24-12-16)28-20-10-15(8-18-17(20)4-3-7-23-18)14-5-6-19(25)21(9-14)27-2/h3-10,13,16,25H,11-12H2,1-2H3,(H,24,26)/t13-,16-/s2
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n/an/a 0.600n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140395
PNG
(US8912173, 120)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(nc1)C(F)F)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C21H19F2N3O2/c1-12(15-9-20(27)26-11-15)28-19-8-14(7-18-16(19)3-2-6-24-18)13-4-5-17(21(22)23)25-10-13/h2-8,10,12,15,21H,9,11H2,1H3,(H,26,27)/t12-,15-/s2
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n/an/a 0.600n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140365
PNG
(US8912173, 90)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(OC2CCC2)nc1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C24H25N3O3/c1-15(18-12-23(28)26-14-18)29-22-11-17(10-21-20(22)6-3-9-25-21)16-7-8-24(27-13-16)30-19-4-2-5-19/h3,6-11,13,15,18-19H,2,4-5,12,14H2,1H3,(H,26,28)/t15-,18-/s2
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n/an/a 0.600n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140282
PNG
(US8912173, 8)
Show SMILES COc1ccc(cc1OC)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1/C23H24N2O4/c1-14(17-12-23(26)25-13-17)29-21-11-16(9-19-18(21)5-4-8-24-19)15-6-7-20(27-2)22(10-15)28-3/h4-11,14,17H,12-13H2,1-3H3,(H,25,26)/t14-,17-/s2
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n/an/a 0.600n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140307
PNG
(US8912173, 33)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2nc(C)ccc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C25H23N3O2/c1-15-5-6-18-10-17(7-8-22(18)28-15)19-11-23-21(4-3-9-26-23)24(12-19)30-16(2)20-13-25(29)27-14-20/h3-12,16,20H,13-14H2,1-2H3,(H,27,29)/t16-,20-/s2
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n/an/a 0.700n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140316
PNG
(US8912173, 42)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2cnn(C)c2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C23H22N4O2/c1-14(18-11-23(28)25-12-18)29-22-10-17(8-20-19(22)4-3-7-24-20)15-5-6-16-13-26-27(2)21(16)9-15/h3-10,13-14,18H,11-12H2,1-2H3,(H,25,28)/t14-,18-/s2
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n/an/a 0.900n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140295
PNG
(US8912173, 21)
Show SMILES COc1ccc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1/C21H21N3O3/c1-13(16-10-20(25)23-12-16)27-19-9-15(8-18-17(19)4-3-7-22-18)14-5-6-21(26-2)24-11-14/h3-9,11,13,16H,10,12H2,1-2H3,(H,23,25)/t13-,16-/s2
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n/an/a 0.900n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140375
PNG
(US8912173, 100)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1cnc2OCCCc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C23H23N3O3/c1-14(17-11-22(27)25-12-17)29-21-10-16(9-20-19(21)5-2-6-24-20)18-8-15-4-3-7-28-23(15)26-13-18/h2,5-6,8-10,13-14,17H,3-4,7,11-12H2,1H3,(H,25,27)/t14-,17-/s2
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n/an/a 0.900n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140327
PNG
(US8912173, 53)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2C(=O)NCCc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C24H23N3O3/c1-14(18-12-23(28)27-13-18)30-22-11-17(10-21-20(22)3-2-7-25-21)15-4-5-19-16(9-15)6-8-26-24(19)29/h2-5,7,9-11,14,18H,6,8,12-13H2,1H3,(H,26,29)(H,27,28)/t14-,18-/s2
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n/an/a 0.900n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140340
PNG
(US8912173, 66)
Show SMILES CC(C)Oc1ccc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1/C23H25N3O3/c1-14(2)28-23-7-6-16(12-26-23)17-9-20-19(5-4-8-24-20)21(10-17)29-15(3)18-11-22(27)25-13-18/h4-10,12,14-15,18H,11,13H2,1-3H3,(H,25,27)/t15-,18-/s2
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n/an/a 1n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140287
PNG
(US8912173, 13)
Show SMILES COc1cc(ccc1O)-c1cc(OC[C@H]2CNC(=O)O2)c2cccnc2c1 |r|
Show InChI InChI=1/C20H18N2O5/c1-25-19-8-12(4-5-17(19)23)13-7-16-15(3-2-6-21-16)18(9-13)26-11-14-10-22-20(24)27-14/h2-9,14,23H,10-11H2,1H3,(H,22,24)/t14-/s2
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n/an/a 1n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140318
PNG
(US8912173, 44)
Show SMILES Cn1ncc2ccc(cc12)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1
Show InChI InChI=1S/C24H19N5O2/c1-29-22-11-15(6-7-16(22)13-28-29)17-10-20-18(4-2-8-26-20)23(12-17)31-14-21-19(24(25)30)5-3-9-27-21/h2-13H,14H2,1H3,(H2,25,30)
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n/an/a 1n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140276
PNG
(US8912173, 2)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1/C24H26N2O5/c1-14(17-12-23(27)26-13-17)31-20-9-15(8-19-18(20)6-5-7-25-19)16-10-21(28-2)24(30-4)22(11-16)29-3/h5-11,14,17H,12-13H2,1-4H3,(H,26,27)/t14-,17-/s2
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n/an/a 1n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140352
PNG
(US8912173, 77)
Show SMILES CCn1cc(cn1)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1
Show InChI InChI=1S/C21H19N5O2/c1-2-26-12-15(11-25-26)14-9-18-16(5-3-7-23-18)20(10-14)28-13-19-17(21(22)27)6-4-8-24-19/h3-12H,2,13H2,1H3,(H2,22,27)
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n/an/a 1n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140370
PNG
(US8912173, 95)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(CS(C)(=O)=O)nc1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C22H23N3O4S/c1-14(17-10-22(26)25-12-17)29-21-9-16(8-20-19(21)4-3-7-23-20)15-5-6-18(24-11-15)13-30(2,27)28/h3-9,11,14,17H,10,12-13H2,1-2H3,(H,25,26)/t14-,17-/s2
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n/an/a 1.10n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140387
PNG
(US8912173, 112 | US9914735, Example 112)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1cnn(C)c1C)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C20H22N4O2/c1-12-17(11-23-24(12)3)14-7-18-16(5-4-6-21-18)19(8-14)26-13(2)15-9-20(25)22-10-15/h4-8,11,13,15H,9-10H2,1-3H3,(H,22,25)/t13-,15-/s2
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n/an/a 1.20n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140314
PNG
(US8912173, 40)
Show SMILES NC(=O)c1cccnc1COc1cc(cc2ncccc12)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C27H26N4O3/c28-27(32)23-4-2-10-30-25(23)18-34-26-16-21(15-24-22(26)3-1-9-29-24)20-7-5-19(6-8-20)17-31-11-13-33-14-12-31/h1-10,15-16H,11-14,17-18H2,(H2,28,32)
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n/an/a 1.20n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140381
PNG
(US8912173, 106)
Show SMILES Cc1nc2cc(ccc2n1C)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1
Show InChI InChI=1S/C25H21N5O2/c1-15-29-21-11-16(7-8-23(21)30(15)2)17-12-20-18(5-3-9-27-20)24(13-17)32-14-22-19(25(26)31)6-4-10-28-22/h3-13H,14H2,1-2H3,(H2,26,31)
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n/an/a 1.30n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140347
PNG
(US8912173, 72)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(OC2CCOCC2)nc1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C25H27N3O4/c1-16(19-13-24(29)27-15-19)31-23-12-18(11-22-21(23)3-2-8-26-22)17-4-5-25(28-14-17)32-20-6-9-30-10-7-20/h2-5,8,11-12,14,16,19-20H,6-7,9-10,13,15H2,1H3,(H,27,29)/t16-,19-/s2
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n/an/a 1.30n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
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