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Compile Data Set for Download or QSAR

Found 20 hits with Last Name = 'martin' and Initial = 'ni'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50374677
PNG
(CHEMBL405231)
Show SMILES NNC(=N)NCCC[C@H](N)C(O)=O
Show InChI InChI=1S/C6H15N5O2/c7-4(5(12)13)2-1-3-10-6(8)11-9/h4H,1-3,7,9H2,(H,12,13)(H3,8,10,11)/t4-/m0/s1
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2.20E+3n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of full length iNOS by high-throughput oxymyoglobin assay


J Med Chem 51: 924-31 (2008)


Article DOI: 10.1021/jm701119v
BindingDB Entry DOI: 10.7270/Q2639QMP
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50374675
PNG
(CHEMBL272851)
Show SMILES N[C@@H](CCCNC(=N)N(N)CC(F)(F)F)C(O)=O
Show InChI InChI=1S/C8H16F3N5O2/c9-8(10,11)4-16(14)7(13)15-3-1-2-5(12)6(17)18/h5H,1-4,12,14H2,(H2,13,15)(H,17,18)/t5-/m0/s1
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1.05E+4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of full length iNOS by high-throughput oxymyoglobin assay


J Med Chem 51: 924-31 (2008)


Article DOI: 10.1021/jm701119v
BindingDB Entry DOI: 10.7270/Q2639QMP
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50374676
PNG
(CHEMBL272814)
Show SMILES CNNC(=N)NCCC[C@H](N)C(O)=O
Show InChI InChI=1S/C7H17N5O2/c1-10-12-7(9)11-4-2-3-5(8)6(13)14/h5,10H,2-4,8H2,1H3,(H,13,14)(H3,9,11,12)/t5-/m0/s1
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1.64E+4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of full length iNOS by high-throughput oxymyoglobin assay


J Med Chem 51: 924-31 (2008)


Article DOI: 10.1021/jm701119v
BindingDB Entry DOI: 10.7270/Q2639QMP
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50374674
PNG
(CHEMBL408756)
Show SMILES CN(N)C(=N)NCCC[C@H](N)C(O)=O
Show InChI InChI=1S/C7H17N5O2/c1-12(10)7(9)11-4-2-3-5(8)6(13)14/h5H,2-4,8,10H2,1H3,(H2,9,11)(H,13,14)/t5-/m0/s1
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3.41E+4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of full length iNOS by high-throughput oxymyoglobin assay


J Med Chem 51: 924-31 (2008)


Article DOI: 10.1021/jm701119v
BindingDB Entry DOI: 10.7270/Q2639QMP
More data for this
Ligand-Target Pair
Nicotinamide N-methyltransferase (NNMT)


(Homo sapiens (Human))
BDBM13016
PNG
(1,2,3,4-tetrahydroisoquinoline | CHEMBL14346 | THI...)
Show SMILES C1Cc2ccccc2CN1
Show InChI InChI=1S/C9H11N/c1-2-4-9-7-10-6-5-8(9)3-1/h1-4,10H,5-7H2
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4.70E+7 -7.88n/an/an/an/an/a8.637



Utrecht University



Assay Description
Enzyme activity assays were performed as previously described with NNMT (16.25 ug/mL, 550 nM) in 50 mM Tris buffer (pH 8.6) containing 1 mM DTT (all ...


Biochemistry 55: 5307-15 (2016)


Article DOI: 10.1021/acs.biochem.6b00733
BindingDB Entry DOI: 10.7270/Q2H130TH
More data for this
Ligand-Target Pair
Nicotinamide N-methyltransferase (NNMT)


(Homo sapiens (Human))
BDBM60920
PNG
(thionicotinamide)
Show SMILES NC(=S)c1cccnc1
Show InChI InChI=1S/C6H6N2S/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
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6.60E+7 -7.01n/an/an/an/an/a8.637



Utrecht University



Assay Description
Enzyme activity assays were performed as previously described with NNMT (16.25 ug/mL, 550 nM) in 50 mM Tris buffer (pH 8.6) containing 1 mM DTT (all ...


Biochemistry 55: 5307-15 (2016)


Article DOI: 10.1021/acs.biochem.6b00733
BindingDB Entry DOI: 10.7270/Q2H130TH
More data for this
Ligand-Target Pair
Nicotinamide N-methyltransferase (NNMT)


(Homo sapiens (Human))
BDBM60924
PNG
(quinoline 3-carboxamide)
Show SMILES NC(=O)c1cnc2ccccc2c1
Show InChI InChI=1S/C10H8N2O/c11-10(13)8-5-7-3-1-2-4-9(7)12-6-8/h1-6H,(H2,11,13)
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9.70E+7 -6.02n/an/an/an/an/a8.637



Utrecht University



Assay Description
Enzyme activity assays were performed as previously described with NNMT (16.25 ug/mL, 550 nM) in 50 mM Tris buffer (pH 8.6) containing 1 mM DTT (all ...


Biochemistry 55: 5307-15 (2016)


Article DOI: 10.1021/acs.biochem.6b00733
BindingDB Entry DOI: 10.7270/Q2H130TH
More data for this
Ligand-Target Pair
Nicotinamide N-methyltransferase (NNMT)


(Homo sapiens (Human))
BDBM50047015
PNG
(CHEMBL14474 | Chinolin | benzo[b]pyridine | quinol...)
Show SMILES c1ccc2ncccc2c1
Show InChI InChI=1S/C9H7N/c1-2-6-9-8(4-1)5-3-7-10-9/h1-7H
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1.02E+8 -5.89n/an/an/an/an/a8.637



Utrecht University



Assay Description
Enzyme activity assays were performed as previously described with NNMT (16.25 ug/mL, 550 nM) in 50 mM Tris buffer (pH 8.6) containing 1 mM DTT (all ...


Biochemistry 55: 5307-15 (2016)


Article DOI: 10.1021/acs.biochem.6b00733
BindingDB Entry DOI: 10.7270/Q2H130TH
More data for this
Ligand-Target Pair
Nicotinamide N-methyltransferase (NNMT)


(Homo sapiens (Human))
BDBM60921
PNG
(isoquinoline)
Show SMILES c1ccc2cnccc2c1
Show InChI InChI=1S/C9H7N/c1-2-4-9-7-10-6-5-8(9)3-1/h1-7H
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2.02E+8 -4.12n/an/an/an/an/a8.637



Utrecht University



Assay Description
Enzyme activity assays were performed as previously described with NNMT (16.25 ug/mL, 550 nM) in 50 mM Tris buffer (pH 8.6) containing 1 mM DTT (all ...


Biochemistry 55: 5307-15 (2016)


Article DOI: 10.1021/acs.biochem.6b00733
BindingDB Entry DOI: 10.7270/Q2H130TH
More data for this
Ligand-Target Pair
Nicotinamide N-methyltransferase (NNMT)


(Homo sapiens (Human))
BDBM197173
PNG
(Sinefungin)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](C[C@@H]([NH3+])CC[C@H]([NH3+])C([O-])=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/p+1/t6-,7-,8+,10+,11+,14+/s2
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n/an/a 3.90E+3n/an/an/an/a8.637



Utrecht University



Assay Description
Enzyme activity assays were performed as previously described with NNMT (16.25 ug/mL, 550 nM) in 50 mM Tris buffer (pH 8.6) containing 1 mM DTT (all ...


Biochemistry 55: 5307-15 (2016)


Article DOI: 10.1021/acs.biochem.6b00733
BindingDB Entry DOI: 10.7270/Q2H130TH
More data for this
Ligand-Target Pair
Nicotinamide N-methyltransferase (NNMT)


(Homo sapiens (Human))
BDBM197172
PNG
(AdoHcy)
Show SMILES C[S+](CCC([NH3+])C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r|
Show InChI InChI=1/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7?,8-,10-,11-,14-,27?/s2
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n/an/a 2.63E+4n/an/an/an/a8.637



Utrecht University



Assay Description
Enzyme activity assays were performed as previously described with NNMT (16.25 ug/mL, 550 nM) in 50 mM Tris buffer (pH 8.6) containing 1 mM DTT (all ...


Biochemistry 55: 5307-15 (2016)


Article DOI: 10.1021/acs.biochem.6b00733
BindingDB Entry DOI: 10.7270/Q2H130TH
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50374674
PNG
(CHEMBL408756)
Show SMILES CN(N)C(=N)NCCC[C@H](N)C(O)=O
Show InChI InChI=1S/C7H17N5O2/c1-12(10)7(9)11-4-2-3-5(8)6(13)14/h5H,2-4,8,10H2,1H3,(H2,9,11)(H,13,14)/t5-/m0/s1
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n/an/an/a 1.00E+4n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Binding affinity to truncated iNOS construct (1-490) by spectral assay


J Med Chem 51: 924-31 (2008)


Article DOI: 10.1021/jm701119v
BindingDB Entry DOI: 10.7270/Q2639QMP
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50266727
PNG
(4,4-Difluoro-L-arginine | CHEMBL476416)
Show SMILES [#7]\[#6](-[#7])=[#7]\[#6]C(F)(F)[#6]-[#6@H](-[#7+])-[#6](-[#8-])=O |r|
Show InChI InChI=1S/C6H12F2N4O2/c7-6(8,2-12-5(10)11)1-3(9)4(13)14/h3H,1-2,9H2,(H,13,14)(H4,10,11,12)/t3-/m0/s1
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n/an/an/a 3.10E+6n/an/an/an/an/a



University of Utrecht

Curated by ChEMBL


Assay Description
Binding affinity to iNOS with heme domain construct (unknown origin) assessed as spectral binding constant by spectral assay


Bioorg Med Chem Lett 19: 1758-62 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.076
BindingDB Entry DOI: 10.7270/Q2P55NC7
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM21959
PNG
((2S)-2-amino-5-carbamimidamidopentanoic acid | ARG...)
Show SMILES [#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](-[#8])=O
Show InChI InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
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n/an/an/a 7.00E+3n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Binding affinity to truncated iNOS construct (1-490) by spectral assay


J Med Chem 51: 924-31 (2008)


Article DOI: 10.1021/jm701119v
BindingDB Entry DOI: 10.7270/Q2639QMP
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50266728
PNG
(4,4-difluoro-N(gamma)-hydroxy-L-arginine | CHEMBL4...)
Show SMILES NC(NO)=NCC(F)(F)C[C@H]([NH3+])C([O-])=O |r,w:4.4|
Show InChI InChI=1S/C6H12F2N4O3/c7-6(8,1-3(9)4(13)14)2-11-5(10)12-15/h3,15H,1-2,9H2,(H,13,14)(H3,10,11,12)/t3-/m0/s1
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n/an/an/a 1.16E+5n/an/an/an/an/a



University of Utrecht

Curated by ChEMBL


Assay Description
Binding affinity to iNOS with heme domain construct (unknown origin) assessed as spectral binding constant by spectral assay


Bioorg Med Chem Lett 19: 1758-62 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.076
BindingDB Entry DOI: 10.7270/Q2P55NC7
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50374676
PNG
(CHEMBL272814)
Show SMILES CNNC(=N)NCCC[C@H](N)C(O)=O
Show InChI InChI=1S/C7H17N5O2/c1-10-12-7(9)11-4-2-3-5(8)6(13)14/h5,10H,2-4,8H2,1H3,(H,13,14)(H3,9,11,12)/t5-/m0/s1
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n/an/an/a 2.90E+4n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Binding affinity to truncated iNOS construct (1-490) by spectral assay


J Med Chem 51: 924-31 (2008)


Article DOI: 10.1021/jm701119v
BindingDB Entry DOI: 10.7270/Q2639QMP
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50374677
PNG
(CHEMBL405231)
Show SMILES NNC(=N)NCCC[C@H](N)C(O)=O
Show InChI InChI=1S/C6H15N5O2/c7-4(5(12)13)2-1-3-10-6(8)11-9/h4H,1-3,7,9H2,(H,12,13)(H3,8,10,11)/t4-/m0/s1
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n/an/an/a 1.30E+3n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Binding affinity to truncated iNOS construct (1-490) by spectral assay


J Med Chem 51: 924-31 (2008)


Article DOI: 10.1021/jm701119v
BindingDB Entry DOI: 10.7270/Q2639QMP
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50230418
PNG
(CHEMBL260629 | N(gamma)-hydroxy-L-arginine | N-OME...)
Show SMILES NC(NO)=NCCC[C@H]([NH3+])C([O-])=O |r,w:4.4|
Show InChI InChI=1S/C6H14N4O3/c7-4(5(11)12)2-1-3-9-6(8)10-13/h4,13H,1-3,7H2,(H,11,12)(H3,8,9,10)/t4-/m0/s1
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n/an/an/a 5.10E+3n/an/an/an/an/a



University of Utrecht

Curated by ChEMBL


Assay Description
Binding affinity to iNOS with heme domain construct (unknown origin) assessed as spectral binding constant by spectral assay


Bioorg Med Chem Lett 19: 1758-62 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.076
BindingDB Entry DOI: 10.7270/Q2P55NC7
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM21959
PNG
((2S)-2-amino-5-carbamimidamidopentanoic acid | ARG...)
Show SMILES [#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](-[#8])=O
Show InChI InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
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n/an/an/a 7.00E+3n/an/an/an/an/a



University of Utrecht

Curated by ChEMBL


Assay Description
Binding affinity to iNOS with heme domain construct (unknown origin) assessed as spectral binding constant by spectral assay


Bioorg Med Chem Lett 19: 1758-62 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.076
BindingDB Entry DOI: 10.7270/Q2P55NC7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50374675
PNG
(CHEMBL272851)
Show SMILES N[C@@H](CCCNC(=N)N(N)CC(F)(F)F)C(O)=O
Show InChI InChI=1S/C8H16F3N5O2/c9-8(10,11)4-16(14)7(13)15-3-1-2-5(12)6(17)18/h5H,1-4,12,14H2,(H2,13,15)(H,17,18)/t5-/m0/s1
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n/an/an/a 4.04E+4n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Binding affinity to truncated iNOS construct (1-490) by spectral assay


J Med Chem 51: 924-31 (2008)


Article DOI: 10.1021/jm701119v
BindingDB Entry DOI: 10.7270/Q2639QMP
More data for this
Ligand-Target Pair