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Compile Data Set for Download or QSAR

Found 210 hits with Last Name = 'mckenzie' and Initial = 'a'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50401333
PNG
(CHEMBL1230584)
Show SMILES COc1c(C)cnc(Cn2cc(C#CCC(C)(C)O)c3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C21H24ClN5O2/c1-12-9-24-15(13(2)17(12)29-5)11-27-10-14(7-6-8-21(3,4)28)16-18(22)25-20(23)26-19(16)27/h9-10,28H,8,11H2,1-5H3,(H2,23,25,26)
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0.200n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Binding affinity at recombinant Hsp90alpha incubated for 16 hrs by fluorescence polarization competition assay


J Med Chem 55: 7786-95 (2012)


Article DOI: 10.1021/jm300810x
BindingDB Entry DOI: 10.7270/Q2V125Z3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM20800
PNG
(2-amino-6-halopurine analogue, 20 | 6-chloro-9-[(4...)
Show SMILES COc1c(C)cnc(Cn2cnc3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C14H15ClN6O/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4,6H,5H2,1-3H3,(H2,16,19,20)
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1.70n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Binding affinity at recombinant Hsp90alpha incubated for 16 hrs by fluorescence polarization competition assay


J Med Chem 55: 7786-95 (2012)


Article DOI: 10.1021/jm300810x
BindingDB Entry DOI: 10.7270/Q2V125Z3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucose regulated protein 94kDa (Grp94)


(Homo sapiens (Human))
BDBM50401333
PNG
(CHEMBL1230584)
Show SMILES COc1c(C)cnc(Cn2cc(C#CCC(C)(C)O)c3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C21H24ClN5O2/c1-12-9-24-15(13(2)17(12)29-5)11-27-10-14(7-6-8-21(3,4)28)16-18(22)25-20(23)26-19(16)27/h9-10,28H,8,11H2,1-5H3,(H2,23,25,26)
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61n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Binding affinity at Grp94 incubated for 16 hrs by fluorescence polarization competition assay


J Med Chem 55: 7786-95 (2012)


Article DOI: 10.1021/jm300810x
BindingDB Entry DOI: 10.7270/Q2V125Z3
More data for this
Ligand-Target Pair
Heat shock protein 75 kDa, mitochondrial


(Homo sapiens (Human))
BDBM50401333
PNG
(CHEMBL1230584)
Show SMILES COc1c(C)cnc(Cn2cc(C#CCC(C)(C)O)c3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C21H24ClN5O2/c1-12-9-24-15(13(2)17(12)29-5)11-27-10-14(7-6-8-21(3,4)28)16-18(22)25-20(23)26-19(16)27/h9-10,28H,8,11H2,1-5H3,(H2,23,25,26)
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255n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Binding affinity at TRAP1 incubated for 16 hrs by fluorescence polarization competition assay


J Med Chem 55: 7786-95 (2012)


Article DOI: 10.1021/jm300810x
BindingDB Entry DOI: 10.7270/Q2V125Z3
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50401335
PNG
(CHEMBL2205798)
Show SMILES COc1c(C)cnc(Cn2cc(C#CCO)c3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C18H18ClN5O2/c1-10-7-21-13(11(2)15(10)26-3)9-24-8-12(5-4-6-25)14-16(19)22-18(20)23-17(14)24/h7-8,25H,6,9H2,1-3H3,(H2,20,22,23)
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n/an/a 0.700n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of Hsp90alpha


J Med Chem 55: 7786-95 (2012)


Article DOI: 10.1021/jm300810x
BindingDB Entry DOI: 10.7270/Q2V125Z3
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50401336
PNG
(CHEMBL2205245)
Show SMILES COc1c(C)cnc(Cn2cc(C#C)c3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C17H16ClN5O/c1-5-11-7-23(16-13(11)15(18)21-17(19)22-16)8-12-10(3)14(24-4)9(2)6-20-12/h1,6-7H,8H2,2-4H3,(H2,19,21,22)
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n/an/a 1n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of Hsp90alpha


J Med Chem 55: 7786-95 (2012)


Article DOI: 10.1021/jm300810x
BindingDB Entry DOI: 10.7270/Q2V125Z3
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50401333
PNG
(CHEMBL1230584)
Show SMILES COc1c(C)cnc(Cn2cc(C#CCC(C)(C)O)c3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C21H24ClN5O2/c1-12-9-24-15(13(2)17(12)29-5)11-27-10-14(7-6-8-21(3,4)28)16-18(22)25-20(23)26-19(16)27/h9-10,28H,8,11H2,1-5H3,(H2,23,25,26)
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n/an/a 1.10n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of Hsp90alpha


J Med Chem 55: 7786-95 (2012)


Article DOI: 10.1021/jm300810x
BindingDB Entry DOI: 10.7270/Q2V125Z3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50401334
PNG
(CHEMBL2205799)
Show SMILES COc1c(C)cnc(Cn2cc(C#CCCO)c3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C19H20ClN5O2/c1-11-8-22-14(12(2)16(11)27-3)10-25-9-13(6-4-5-7-26)15-17(20)23-19(21)24-18(15)25/h8-9,26H,5,7,10H2,1-3H3,(H2,21,23,24)
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n/an/a 2n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of Hsp90alpha


J Med Chem 55: 7786-95 (2012)


Article DOI: 10.1021/jm300810x
BindingDB Entry DOI: 10.7270/Q2V125Z3
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50378702
PNG
(CHEMBL560895 | SNX-2112)
Show InChI InChI=1S/C23H27F3N4O3/c1-22(2)10-17-19(18(32)11-22)20(23(24,25)26)29-30(17)13-5-8-15(21(27)33)16(9-13)28-12-3-6-14(31)7-4-12/h5,8-9,12,14,28,31H,3-4,6-7,10-11H2,1-2H3,(H2,27,33)/t12-,14-
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n/an/a 3n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of Hsp90alpha


J Med Chem 55: 7786-95 (2012)


Article DOI: 10.1021/jm300810x
BindingDB Entry DOI: 10.7270/Q2V125Z3
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50401332
PNG
(CHEMBL2205800)
Show SMILES COc1c(C)cnc(Cn2cc(CCCO)c3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C18H22ClN5O2/c1-10-7-21-13(11(2)15(10)26-3)9-24-8-12(5-4-6-25)14-16(19)22-18(20)23-17(14)24/h7-8,25H,4-6,9H2,1-3H3,(H2,20,22,23)
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n/an/a 3.90n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of Hsp90alpha


J Med Chem 55: 7786-95 (2012)


Article DOI: 10.1021/jm300810x
BindingDB Entry DOI: 10.7270/Q2V125Z3
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM20800
PNG
(2-amino-6-halopurine analogue, 20 | 6-chloro-9-[(4...)
Show SMILES COc1c(C)cnc(Cn2cnc3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C14H15ClN6O/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4,6H,5H2,1-3H3,(H2,16,19,20)
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n/an/a 5.10n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of Hsp90alpha


J Med Chem 55: 7786-95 (2012)


Article DOI: 10.1021/jm300810x
BindingDB Entry DOI: 10.7270/Q2V125Z3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50401337
PNG
(CHEMBL2205244)
Show SMILES COc1c(C)cnc(Cn2cc(-c3ccccc3)c3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C21H20ClN5O/c1-12-9-24-16(13(2)18(12)28-3)11-27-10-15(14-7-5-4-6-8-14)17-19(22)25-21(23)26-20(17)27/h4-10H,11H2,1-3H3,(H2,23,25,26)
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n/an/a 6n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of Hsp90alpha


J Med Chem 55: 7786-95 (2012)


Article DOI: 10.1021/jm300810x
BindingDB Entry DOI: 10.7270/Q2V125Z3
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM50161155
PNG
(CHEMBL3793229)
Show SMILES Cc1ccc(cc1C)S(=O)(=O)N(CC(F)(F)F)c1ccc2N(CCCc2c1)C(=O)c1c(F)cccc1Cl
Show InChI InChI=1S/C18H18ClN3O/c1-22-8-7-12-9-14(19)16-17(21-18(23)20-16)15(12)13(10-22)11-5-3-2-4-6-11/h2-6,9,13H,7-8,10H2,1H3,(H2,20,21,23)/t13-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Biogen

Curated by ChEMBL


Assay Description
Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...


Bioorg Med Chem Lett 26: 2459-63 (2016)


BindingDB Entry DOI: 10.7270/Q2QC05DC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM50161156
PNG
(CHEMBL3793914)
Show SMILES Cn1ccc2c(cccc12)S(=O)(=O)N(CC(F)(F)F)c1ccc2N(CCCc2c1)C(=O)c1cccs1
Show InChI InChI=1S/C20H20ClN3S/c1-24-9-8-12-10-14(21)18-19(23-20(25)22-18)16(12)17-13-5-3-2-4-11(13)6-7-15(17)24/h2-5,10,15,17H,6-9H2,1H3,(H2,22,23,25)/t15-,17-/m0/s1
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n/an/a 56n/an/an/an/an/an/a



Biogen

Curated by ChEMBL


Assay Description
Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...


Bioorg Med Chem Lett 26: 2459-63 (2016)


BindingDB Entry DOI: 10.7270/Q2QC05DC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM50161154
PNG
(CHEMBL3793036)
Show SMILES Cn1ccc2c(cccc12)S(=O)(=O)N(CC(F)(F)F)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H19ClN2OS/c1-23-9-8-12-10-14(21)18-19(25-20(24)22-18)16(12)17-13-5-3-2-4-11(13)6-7-15(17)23/h2-5,10,15,17H,6-9H2,1H3,(H,22,24)/t15-,17-/m0/s1
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n/an/a 72n/an/an/an/an/an/a



Biogen

Curated by ChEMBL


Assay Description
Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...


Bioorg Med Chem Lett 26: 2459-63 (2016)


BindingDB Entry DOI: 10.7270/Q2QC05DC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM50161145
PNG
(CHEMBL3793667)
Show SMILES OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1cccc(Cl)c1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H11ClF9NO3S/c18-11-2-1-3-13(8-11)32(30,31)28(9-14(19,20)21)12-6-4-10(5-7-12)15(29,16(22,23)24)17(25,26)27/h1-8,29H,9H2
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n/an/a 72n/an/an/an/an/an/a



Biogen

Curated by ChEMBL


Assay Description
Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...


Bioorg Med Chem Lett 26: 2459-63 (2016)


BindingDB Entry DOI: 10.7270/Q2QC05DC
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50147513
PNG
(2-[3-[5-(4-Chloro-phenyl)-benzooxazol-2-yl]-4-(2-m...)
Show SMILES COCCNc1ccc(cc1-c1nc2cc(ccc2o1)-c1ccc(Cl)cc1)N1C(=O)c2ccc(cc2C1=O)C(O)=O
Show InChI InChI=1S/C31H22ClN3O6/c1-40-13-12-33-25-10-8-21(35-29(36)22-9-4-19(31(38)39)14-23(22)30(35)37)16-24(25)28-34-26-15-18(5-11-27(26)41-28)17-2-6-20(32)7-3-17/h2-11,14-16,33H,12-13H2,1H3,(H,38,39)
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n/an/a 200n/an/an/an/an/an/a



Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vivo inhibitory activity against human Heparanase


Bioorg Med Chem Lett 14: 3269-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.086
BindingDB Entry DOI: 10.7270/Q2CC1040
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50147546
PNG
(2-(3-(5-(benzo[d][1,3]dioxol-5-yl)benzo[d]oxazol-2...)
Show SMILES COc1ccc(cc1-c1nc2cc(ccc2o1)-c1ccc2OCOc2c1)N1C(=O)c2ccc(cc2C1=O)C(O)=O
Show InChI InChI=1S/C30H18N2O8/c1-37-23-9-5-18(32-28(33)19-6-2-17(30(35)36)10-20(19)29(32)34)13-21(23)27-31-22-11-15(3-7-24(22)40-27)16-4-8-25-26(12-16)39-14-38-25/h2-13H,14H2,1H3,(H,35,36)
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n/an/a 200n/an/an/an/an/an/a



Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vivo inhibitory activity against human Heparanase


Bioorg Med Chem Lett 14: 3269-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.086
BindingDB Entry DOI: 10.7270/Q2CC1040
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM50161157
PNG
(CHEMBL3792836)
Show SMILES Cc1ccc(cc1C)S(=O)(=O)N(CC(F)(F)F)c1ccc2N(CCCc2c1)C(=O)c1cccs1
Show InChI InChI=1S/C17H16ClN3/c18-15-8-12-6-7-19-9-13(11-4-2-1-3-5-11)16(12)14-10-20-21-17(14)15/h1-5,8,10,13,19H,6-7,9H2,(H,20,21)/t13-/m1/s1
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n/an/a 200n/an/an/an/an/an/a



Biogen

Curated by ChEMBL


Assay Description
Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...


Bioorg Med Chem Lett 26: 2459-63 (2016)


BindingDB Entry DOI: 10.7270/Q2QC05DC
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165669
PNG
((2-{4-[2-(3-Bromo-phenylcarbamoyl)-vinyl]-2-fluoro...)
Show SMILES OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(\C=C\C(=O)Nc2cccc(Br)c2)cc1F
Show InChI InChI=1S/C24H16BrFN2O4/c25-16-2-1-3-17(13-16)27-22(29)9-6-14-4-7-18(19(26)10-14)24-28-20-11-15(12-23(30)31)5-8-21(20)32-24/h1-11,13H,12H2,(H,27,29)(H,30,31)/b9-6+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165653
PNG
((2-{4-[2-(3,4-Dichloro-phenylcarbamoyl)-vinyl]-2-f...)
Show SMILES OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(\C=C\C(=O)Nc2ccc(Cl)c(Cl)c2)cc1F
Show InChI InChI=1S/C24H15Cl2FN2O4/c25-17-6-4-15(12-18(17)26)28-22(30)8-3-13-1-5-16(19(27)9-13)24-29-20-10-14(11-23(31)32)2-7-21(20)33-24/h1-10,12H,11H2,(H,28,30)(H,31,32)/b8-3+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165660
PNG
(2-(3-(5-(4-chlorophenyl)benzo[d]oxazol-2-yl)-4-(pr...)
Show SMILES CCCNc1ccc(cc1-c1nc2cc(ccc2o1)-c1ccc(Cl)cc1)N1C(=O)c2ccc(cc2C1=O)C(O)=O
Show InChI InChI=1S/C31H22ClN3O5/c1-2-13-33-25-11-9-21(35-29(36)22-10-5-19(31(38)39)14-23(22)30(35)37)16-24(25)28-34-26-15-18(6-12-27(26)40-28)17-3-7-20(32)8-4-17/h3-12,14-16,33H,2,13H2,1H3,(H,38,39)
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165639
PNG
((2-{4-[2-(2,4-Dichloro-phenylcarbamoyl)-vinyl]-2-f...)
Show SMILES OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(\C=C\C(=O)Nc2ccc(Cl)cc2Cl)cc1F
Show InChI InChI=1S/C24H15Cl2FN2O4/c25-15-4-6-19(17(26)12-15)28-22(30)8-3-13-1-5-16(18(27)9-13)24-29-20-10-14(11-23(31)32)2-7-21(20)33-24/h1-10,12H,11H2,(H,28,30)(H,31,32)/b8-3+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM19993
PNG
(CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...)
Show SMILES OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
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Biogen

Curated by ChEMBL


Assay Description
Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...


Bioorg Med Chem Lett 26: 2459-63 (2016)


BindingDB Entry DOI: 10.7270/Q2QC05DC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM50161110
PNG
(CHEMBL3792639)
Show SMILES Cc1cc(O)ccc1-c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1cccc2n(C)ccc12
Show InChI InChI=1S/C24H21F3N2O3S/c1-16-14-19(30)10-11-20(16)17-6-8-18(9-7-17)29(15-24(25,26)27)33(31,32)23-5-3-4-22-21(23)12-13-28(22)2/h3-14,30H,15H2,1-2H3
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Biogen

Curated by ChEMBL


Assay Description
Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...


Bioorg Med Chem Lett 26: 2459-63 (2016)


BindingDB Entry DOI: 10.7270/Q2QC05DC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM50108881
PNG
(CHEMBL3596591)
Show SMILES NC(=O)c1ccc(Cl)c(c1)-c1ccc2N(CCCc2c1)C(=O)c1c(F)cccc1Cl
Show InChI InChI=1S/C23H17Cl2FN2O2/c24-17-8-6-15(22(27)29)12-16(17)13-7-9-20-14(11-13)3-2-10-28(20)23(30)21-18(25)4-1-5-19(21)26/h1,4-9,11-12H,2-3,10H2,(H2,27,29)
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Biogen

Curated by ChEMBL


Assay Description
Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...


Bioorg Med Chem Lett 26: 2459-63 (2016)


BindingDB Entry DOI: 10.7270/Q2QC05DC
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50147534
PNG
(1,3-Dioxo-2-[3-(5-phenyl-benzooxazol-2-yl)-4-propy...)
Show SMILES CCCNc1ccc(cc1-c1nc2cc(ccc2o1)-c1ccccc1)N1C(=O)c2ccc(cc2C1=O)C(O)=O
Show InChI InChI=1S/C31H23N3O5/c1-2-14-32-25-12-10-21(34-29(35)22-11-8-20(31(37)38)15-23(22)30(34)36)17-24(25)28-33-26-16-19(9-13-27(26)39-28)18-6-4-3-5-7-18/h3-13,15-17,32H,2,14H2,1H3,(H,37,38)
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vivo inhibitory activity against human Heparanase


Bioorg Med Chem Lett 14: 3269-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.086
BindingDB Entry DOI: 10.7270/Q2CC1040
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165614
PNG
((2-{4-[3-((E)-3-Chloro-2-fluoro-phenyl)-acryloylam...)
Show SMILES OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(NC(=O)\C=C\c2cccc(Cl)c2F)c(F)c1
Show InChI InChI=1S/C24H15ClF2N2O4/c25-16-3-1-2-14(23(16)27)6-9-21(30)28-18-7-5-15(12-17(18)26)24-29-19-10-13(11-22(31)32)4-8-20(19)33-24/h1-10,12H,11H2,(H,28,30)(H,31,32)/b9-6+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165638
PNG
((2-{4-[2-(4-Cyano-phenylcarbamoyl)-vinyl]-2-fluoro...)
Show SMILES OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(\C=C\C(=O)Nc2ccc(cc2)C#N)cc1F
Show InChI InChI=1S/C25H16FN3O4/c26-20-11-15(5-10-23(30)28-18-6-1-16(14-27)2-7-18)3-8-19(20)25-29-21-12-17(13-24(31)32)4-9-22(21)33-25/h1-12H,13H2,(H,28,30)(H,31,32)/b10-5+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165627
PNG
((2-{4-[2-(3-Fluoro-4-methoxy-phenylcarbamoyl)-viny...)
Show SMILES COc1ccc(NC(=O)\C=C\c2ccc(cc2)-c2nc3cc(CC(O)=O)ccc3o2)cc1F
Show InChI InChI=1S/C25H19FN2O5/c1-32-21-10-8-18(14-19(21)26)27-23(29)11-5-15-2-6-17(7-3-15)25-28-20-12-16(13-24(30)31)4-9-22(20)33-25/h2-12,14H,13H2,1H3,(H,27,29)(H,30,31)/b11-5+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165640
PNG
(2-(4-(5-(2-chloro-4-(3-(2,4-dichlorophenyl)acrylam...)
Show SMILES OC(=O)Cc1nc(cs1)-c1ccc(o1)-c1ccc(NC(=O)\C=C\c2ccc(Cl)cc2Cl)cc1Cl
Show InChI InChI=1S/C24H15Cl3N2O4S/c25-14-3-1-13(17(26)9-14)2-8-22(30)28-15-4-5-16(18(27)10-15)20-6-7-21(33-20)19-12-34-23(29-19)11-24(31)32/h1-10,12H,11H2,(H,28,30)(H,31,32)/b8-2+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165621
PNG
((2-{2-Chloro-4-[3-((E)-2,4-dichloro-phenyl)-acrylo...)
Show SMILES OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(NC(=O)\C=C\c2ccc(Cl)cc2Cl)cc1Cl
Show InChI InChI=1S/C24H15Cl3N2O4/c25-15-4-2-14(18(26)11-15)3-8-22(30)28-16-5-6-17(19(27)12-16)24-29-20-9-13(10-23(31)32)1-7-21(20)33-24/h1-9,11-12H,10H2,(H,28,30)(H,31,32)/b8-3+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165624
PNG
((2-{4-[3-((E)-2,4-Dichloro-phenyl)-acryloylamino]-...)
Show SMILES OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(NC(=O)\C=C\c2ccc(Cl)cc2Cl)c(F)c1
Show InChI InChI=1S/C24H15Cl2FN2O4/c25-16-5-2-14(17(26)12-16)4-8-22(30)28-19-6-3-15(11-18(19)27)24-29-20-9-13(10-23(31)32)1-7-21(20)33-24/h1-9,11-12H,10H2,(H,28,30)(H,31,32)/b8-4+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50147544
PNG
(2-(2-methoxy-5-(5-(4-(trifluoromethoxy)phenyl)benz...)
Show SMILES COc1ccc(cc1N1C(=O)c2ccc(cc2C1=O)C(O)=O)-c1nc2cc(ccc2o1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C30H17F3N2O7/c1-40-25-11-6-17(14-23(25)35-27(36)20-9-4-18(29(38)39)12-21(20)28(35)37)26-34-22-13-16(5-10-24(22)41-26)15-2-7-19(8-3-15)42-30(31,32)33/h2-14H,1H3,(H,38,39)
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vivo inhibitory activity against human Heparanase


Bioorg Med Chem Lett 14: 3269-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.086
BindingDB Entry DOI: 10.7270/Q2CC1040
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165663
PNG
((2-{4-[2-(4-Bromo-phenylcarbamoyl)-vinyl]-2-fluoro...)
Show SMILES OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(\C=C\C(=O)Nc2ccc(Br)cc2)cc1F
Show InChI InChI=1S/C24H16BrFN2O4/c25-16-4-6-17(7-5-16)27-22(29)10-3-14-1-8-18(19(26)11-14)24-28-20-12-15(13-23(30)31)2-9-21(20)32-24/h1-12H,13H2,(H,27,29)(H,30,31)/b10-3+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165636
PNG
(2-(4-(5-(4-(3-(4-bromophenyl)acrylamido)-2-chlorop...)
Show SMILES OC(=O)Cc1nc(cs1)-c1ccc(o1)-c1ccc(NC(=O)\C=C\c2ccc(Br)cc2)cc1Cl
Show InChI InChI=1S/C24H16BrClN2O4S/c25-15-4-1-14(2-5-15)3-10-22(29)27-16-6-7-17(18(26)11-16)20-8-9-21(32-20)19-13-33-23(28-19)12-24(30)31/h1-11,13H,12H2,(H,27,29)(H,30,31)/b10-3+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50147533
PNG
(2-(5-(5-(3,5-difluorophenyl)benzo[d]oxazol-2-yl)-2...)
Show SMILES COc1ccc(cc1N1C(=O)c2ccc(cc2C1=O)C(O)=O)-c1nc2cc(ccc2o1)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C29H16F2N2O6/c1-38-25-7-4-15(12-23(25)33-27(34)20-5-2-16(29(36)37)10-21(20)28(33)35)26-32-22-11-14(3-6-24(22)39-26)17-8-18(30)13-19(31)9-17/h2-13H,1H3,(H,36,37)
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vivo inhibitory activity against human Heparanase


Bioorg Med Chem Lett 14: 3269-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.086
BindingDB Entry DOI: 10.7270/Q2CC1040
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50147522
PNG
(2-(4-(butylamino)-3-(5-phenylbenzo[d]oxazol-2-yl)p...)
Show SMILES CCCCNc1ccc(cc1-c1nc2cc(ccc2o1)-c1ccccc1)N1C(=O)c2ccc(cc2C1=O)C(O)=O
Show InChI InChI=1S/C32H25N3O5/c1-2-3-15-33-26-13-11-22(35-30(36)23-12-9-21(32(38)39)16-24(23)31(35)37)18-25(26)29-34-27-17-20(10-14-28(27)40-29)19-7-5-4-6-8-19/h4-14,16-18,33H,2-3,15H2,1H3,(H,38,39)
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vivo inhibitory activity against human Heparanase


Bioorg Med Chem Lett 14: 3269-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.086
BindingDB Entry DOI: 10.7270/Q2CC1040
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165620
PNG
(2-(4-(5-(2-chloro-4-(3-(4-methoxyphenyl)acrylamido...)
Show SMILES COc1ccc(\C=C\C(=O)Nc2ccc(-c3ccc(o3)-c3csc(CC(O)=O)n3)c(Cl)c2)cc1
Show InChI InChI=1S/C25H19ClN2O5S/c1-32-17-6-2-15(3-7-17)4-11-23(29)27-16-5-8-18(19(26)12-16)21-9-10-22(33-21)20-14-34-24(28-20)13-25(30)31/h2-12,14H,13H2,1H3,(H,27,29)(H,30,31)/b11-4+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50147537
PNG
(2-(5-(5-(4-fluorophenyl)benzo[d]oxazol-2-yl)-2-met...)
Show SMILES COc1ccc(cc1N1C(=O)c2ccc(cc2C1=O)C(O)=O)-c1nc2cc(ccc2o1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H17FN2O6/c1-37-25-11-6-17(14-23(25)32-27(33)20-9-4-18(29(35)36)12-21(20)28(32)34)26-31-22-13-16(5-10-24(22)38-26)15-2-7-19(30)8-3-15/h2-14H,1H3,(H,35,36)
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vivo inhibitory activity against human Heparanase


Bioorg Med Chem Lett 14: 3269-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.086
BindingDB Entry DOI: 10.7270/Q2CC1040
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165613
PNG
((2-{4-[3-((E)-4-Bromo-phenyl)-acryloylamino]-2-chl...)
Show SMILES OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(NC(=O)\C=C\c2ccc(Br)cc2)cc1Cl
Show InChI InChI=1S/C24H16BrClN2O4/c25-16-5-1-14(2-6-16)4-10-22(29)27-17-7-8-18(19(26)13-17)24-28-20-11-15(12-23(30)31)3-9-21(20)32-24/h1-11,13H,12H2,(H,27,29)(H,30,31)/b10-4+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165652
PNG
((2-{4-[3-((E)-4-Bromo-phenyl)-acryloylamino]-3-flu...)
Show SMILES OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(NC(=O)\C=C\c2ccc(Br)cc2)c(F)c1
Show InChI InChI=1S/C24H16BrFN2O4/c25-17-6-1-14(2-7-17)4-10-22(29)27-19-8-5-16(13-18(19)26)24-28-20-11-15(12-23(30)31)3-9-21(20)32-24/h1-11,13H,12H2,(H,27,29)(H,30,31)/b10-4+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165615
PNG
((2-{4-[2-(2,4-Dichloro-phenylcarbamoyl)-vinyl]-phe...)
Show SMILES OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(\C=C\C(=O)Nc2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C24H16Cl2N2O4/c25-17-7-8-19(18(26)13-17)27-22(29)10-4-14-1-5-16(6-2-14)24-28-20-11-15(12-23(30)31)3-9-21(20)32-24/h1-11,13H,12H2,(H,27,29)(H,30,31)/b10-4+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50147539
PNG
(2-(2-methoxy-5-(5-(4-methoxyphenyl)benzo[d]oxazol-...)
Show SMILES COc1ccc(cc1)-c1ccc2oc(nc2c1)-c1ccc(OC)c(c1)N1C(=O)c2ccc(cc2C1=O)C(O)=O
Show InChI InChI=1S/C30H20N2O7/c1-37-20-8-3-16(4-9-20)17-6-11-25-23(14-17)31-27(39-25)18-7-12-26(38-2)24(15-18)32-28(33)21-10-5-19(30(35)36)13-22(21)29(32)34/h3-15H,1-2H3,(H,35,36)
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vivo inhibitory activity against human Heparanase


Bioorg Med Chem Lett 14: 3269-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.086
BindingDB Entry DOI: 10.7270/Q2CC1040
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165643
PNG
((2-{2-Fluoro-4-[2-(2-fluoro-4-methoxy-phenylcarbam...)
Show SMILES COc1ccc(NC(=O)\C=C\c2ccc(-c3nc4cc(CC(O)=O)ccc4o3)c(F)c2)c(F)c1
Show InChI InChI=1S/C25H18F2N2O5/c1-33-16-5-7-20(19(27)13-16)28-23(30)9-4-14-2-6-17(18(26)10-14)25-29-21-11-15(12-24(31)32)3-8-22(21)34-25/h2-11,13H,12H2,1H3,(H,28,30)(H,31,32)/b9-4+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165642
PNG
((4-{5-[2-Chloro-4-(3-phenyl-acryloylamino)-phenyl]...)
Show SMILES OC(=O)Cc1nc(cs1)-c1ccc(o1)-c1ccc(NC(=O)\C=C\c2ccccc2)cc1Cl
Show InChI InChI=1S/C24H17ClN2O4S/c25-18-12-16(26-22(28)11-6-15-4-2-1-3-5-15)7-8-17(18)20-9-10-21(31-20)19-14-32-23(27-19)13-24(29)30/h1-12,14H,13H2,(H,26,28)(H,29,30)/b11-6+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens (Human))
BDBM50165659
PNG
((2-{4-[2-(3-Bromo-phenylcarbamoyl)-vinyl]-phenyl}-...)
Show SMILES OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(\C=C\C(=O)Nc2cccc(Br)c2)cc1
Show InChI InChI=1S/C24H17BrN2O4/c25-18-2-1-3-19(14-18)26-22(28)11-7-15-4-8-17(9-5-15)24-27-20-12-16(13-23(29)30)6-10-21(20)31-24/h1-12,14H,13H2,(H,26,28)(H,29,30)/b11-7+
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Heparanase


Bioorg Med Chem Lett 15: 2295-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.014
BindingDB Entry DOI: 10.7270/Q2BP029G
More data for this
Ligand-Target Pair
Bifunctional protein GlmU


(Streptococcus pneumoniae)
BDBM50365095
PNG
(CHEMBL1951184)
Show SMILES COc1cc(OC)c(cc1NC(=O)CCC(O)=O)S(=O)(=O)NCc1ccccc1N1CCC(COC(=O)CCC(O)=O)CC1
Show InChI InChI=1S/C29H37N3O11S/c1-41-23-16-24(42-2)25(15-21(23)31-26(33)7-8-27(34)35)44(39,40)30-17-20-5-3-4-6-22(20)32-13-11-19(12-14-32)18-43-29(38)10-9-28(36)37/h3-6,15-16,19,30H,7-14,17-18H2,1-2H3,(H,31,33)(H,34,35)(H,36,37)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's meth...


Bioorg Med Chem Lett 22: 1510-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.016
BindingDB Entry DOI: 10.7270/Q23J3DF0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Heparanase


(Homo sapiens (Human))
BDBM50147517
PNG
(2-[3-[5-(4-Fluoro-phenyl)-benzooxazol-2-yl]-4-(2-m...)
Show SMILES COCCNc1ccc(cc1-c1nc2cc(ccc2o1)-c1ccc(F)cc1)N1C(=O)c2ccc(cc2C1=O)C(O)=O
Show InChI InChI=1S/C31H22FN3O6/c1-40-13-12-33-25-10-8-21(35-29(36)22-9-4-19(31(38)39)14-23(22)30(35)37)16-24(25)28-34-26-15-18(5-11-27(26)41-28)17-2-6-20(32)7-3-17/h2-11,14-16,33H,12-13H2,1H3,(H,38,39)
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Celltech R&D Ltd

Curated by ChEMBL


Assay Description
In vivo inhibitory activity against human Heparanase


Bioorg Med Chem Lett 14: 3269-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.086
BindingDB Entry DOI: 10.7270/Q2CC1040
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM50161109
PNG
(CHEMBL3793855)
Show SMILES Cc1cc(O)ccc1-c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H17ClF3NO3S/c1-14-11-18(27)9-10-20(14)15-5-7-17(8-6-15)26(13-21(23,24)25)30(28,29)19-4-2-3-16(22)12-19/h2-12,27H,13H2,1H3
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Biogen

Curated by ChEMBL


Assay Description
Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...


Bioorg Med Chem Lett 26: 2459-63 (2016)


BindingDB Entry DOI: 10.7270/Q2QC05DC
More data for this
Ligand-Target Pair
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