new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 72 hits with Last Name = 'mellor' and Initial = 'ir'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194124
PNG
((S)-N-(1-(5-(6-aminohexylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-5-8-17-26-16-7-4-3-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194124
PNG
((S)-N-(1-(5-(6-aminohexylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-5-8-17-26-16-7-4-3-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
10n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194127
PNG
((S)-N-(1-(5-(7-aminoheptylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCN
Show InChI InChI=1S/C25H44N4O3/c1-2-11-24(31)29-23(20-21-12-14-22(30)15-13-21)25(32)28-19-10-6-9-18-27-17-8-5-3-4-7-16-26/h12-15,23,27,30H,2-11,16-20,26H2,1H3,(H,28,32)(H,29,31)/t23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
10n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194113
PNG
((S)-N-(1-(5-(4-aminobutylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCN
Show InChI InChI=1S/C22H38N4O3/c1-2-8-21(28)26-20(17-18-9-11-19(27)12-10-18)22(29)25-16-6-3-5-14-24-15-7-4-13-23/h9-12,20,24,27H,2-8,13-17,23H2,1H3,(H,25,29)(H,26,28)/t20-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
13n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194123
PNG
((S)-N-(1-(5-(5-aminopentylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCN
Show InChI InChI=1S/C23H40N4O3/c1-2-9-22(29)27-21(18-19-10-12-20(28)13-11-19)23(30)26-17-8-4-7-16-25-15-6-3-5-14-24/h10-13,21,25,28H,2-9,14-18,24H2,1H3,(H,26,30)(H,27,29)/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
13n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194118
PNG
((S)-N-(1-(5-(3-aminopropylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCN
Show InChI InChI=1S/C21H36N4O3/c1-2-7-20(27)25-19(16-17-8-10-18(26)11-9-17)21(28)24-15-5-3-4-13-23-14-6-12-22/h8-11,19,23,26H,2-7,12-16,22H2,1H3,(H,24,28)(H,25,27)/t19-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
14n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194111
PNG
((S)-N-(1-(5-(10-aminodecylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCCN
Show InChI InChI=1S/C28H50N4O3/c1-2-14-27(34)32-26(23-24-15-17-25(33)18-16-24)28(35)31-22-13-9-12-21-30-20-11-8-6-4-3-5-7-10-19-29/h15-18,26,30,33H,2-14,19-23,29H2,1H3,(H,31,35)(H,32,34)/t26-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
26n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194114
PNG
((S)-N-(1-(9-(6-aminohexylamino)nonylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCCNCCCCCCN
Show InChI InChI=1S/C28H50N4O3/c1-2-14-27(34)32-26(23-24-15-17-25(33)18-16-24)28(35)31-22-13-8-5-3-4-7-11-20-30-21-12-9-6-10-19-29/h15-18,26,30,33H,2-14,19-23,29H2,1H3,(H,31,35)(H,32,34)/t26-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
37n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194109
PNG
((S)-N-(1-(5-(8-aminooctylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCN
Show InChI InChI=1S/C26H46N4O3/c1-2-12-25(32)30-24(21-22-13-15-23(31)16-14-22)26(33)29-20-11-7-10-19-28-18-9-6-4-3-5-8-17-27/h13-16,24,28,31H,2-12,17-21,27H2,1H3,(H,29,33)(H,30,32)/t24-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
37n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194119
PNG
((S)-N-(1-(4-(7-aminoheptylamino)butylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCNCCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-8-17-26-16-7-5-3-4-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
38n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194120
PNG
((S)-N-(1-(4-(6-aminohexylamino)butylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCNCCCCCCN
Show InChI InChI=1S/C23H40N4O3/c1-2-9-22(29)27-21(18-19-10-12-20(28)13-11-19)23(30)26-17-8-7-16-25-15-6-4-3-5-14-24/h10-13,21,25,28H,2-9,14-18,24H2,1H3,(H,26,30)(H,27,29)/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
53n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194118
PNG
((S)-N-(1-(5-(3-aminopropylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCN
Show InChI InChI=1S/C21H36N4O3/c1-2-7-20(27)25-19(16-17-8-10-18(26)11-9-17)21(28)24-15-5-3-4-13-23-14-6-12-22/h8-11,19,23,26H,2-7,12-16,22H2,1H3,(H,24,28)(H,25,27)/t19-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
63n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194117
PNG
((S)-N-(1-(5-(9-aminononylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCN
Show InChI InChI=1S/C27H48N4O3/c1-2-13-26(33)31-25(22-23-14-16-24(32)17-15-23)27(34)30-21-12-8-11-20-29-19-10-7-5-3-4-6-9-18-28/h14-17,25,29,32H,2-13,18-22,28H2,1H3,(H,30,34)(H,31,33)/t25-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
65n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194122
PNG
((S)-N-(1-(8-(3-aminopropylamino)octylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-8-6-4-3-5-7-16-26-17-9-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
65n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194113
PNG
((S)-N-(1-(5-(4-aminobutylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCN
Show InChI InChI=1S/C22H38N4O3/c1-2-8-21(28)26-20(17-18-9-11-19(27)12-10-18)22(29)25-16-6-3-5-14-24-15-7-4-13-23/h9-12,20,24,27H,2-8,13-17,23H2,1H3,(H,25,29)(H,26,28)/t20-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
68n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194112
PNG
((S)-N-(1-(5-(12-aminododecylamino)pentylamino)-3-(...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCCCCN
Show InChI InChI=1S/C30H54N4O3/c1-2-16-29(36)34-28(25-26-17-19-27(35)20-18-26)30(37)33-24-15-11-14-23-32-22-13-10-8-6-4-3-5-7-9-12-21-31/h17-20,28,32,35H,2-16,21-25,31H2,1H3,(H,33,37)(H,34,36)/t28-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
77n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194126
PNG
((S)-N-(1-(8-(6-aminohexylamino)octylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCCCCN
Show InChI InChI=1S/C27H48N4O3/c1-2-13-26(33)31-25(22-23-14-16-24(32)17-15-23)27(34)30-21-12-7-4-3-6-10-19-29-20-11-8-5-9-18-28/h14-17,25,29,32H,2-13,18-22,28H2,1H3,(H,30,34)(H,31,33)/t25-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
77n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194123
PNG
((S)-N-(1-(5-(5-aminopentylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCN
Show InChI InChI=1S/C23H40N4O3/c1-2-9-22(29)27-21(18-19-10-12-20(28)13-11-19)23(30)26-17-8-4-7-16-25-15-6-3-5-14-24/h10-13,21,25,28H,2-9,14-18,24H2,1H3,(H,26,30)(H,27,29)/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
95n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194127
PNG
((S)-N-(1-(5-(7-aminoheptylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCN
Show InChI InChI=1S/C25H44N4O3/c1-2-11-24(31)29-23(20-21-12-14-22(30)15-13-21)25(32)28-19-10-6-9-18-27-17-8-5-3-4-7-16-26/h12-15,23,27,30H,2-11,16-20,26H2,1H3,(H,28,32)(H,29,31)/t23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
110n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194116
PNG
((S)-N-(1-(3-(6-aminohexylamino)propylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCNCCCCCCN
Show InChI InChI=1S/C22H38N4O3/c1-2-8-21(28)26-20(17-18-9-11-19(27)12-10-18)22(29)25-16-7-15-24-14-6-4-3-5-13-23/h9-12,20,24,27H,2-8,13-17,23H2,1H3,(H,25,29)(H,26,28)/t20-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
126n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194115
PNG
((S)-N-(1-(5-(2-aminoethylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCN
Show InChI InChI=1S/C20H34N4O3/c1-2-6-19(26)24-18(15-16-7-9-17(25)10-8-16)20(27)23-13-5-3-4-12-22-14-11-21/h7-10,18,22,25H,2-6,11-15,21H2,1H3,(H,23,27)(H,24,26)/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
140n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194110
PNG
((S)-N-(1-(7-(4-aminobutylamino)heptylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCNCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-8-5-3-4-7-16-26-17-9-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
168n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194111
PNG
((S)-N-(1-(5-(10-aminodecylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCCN
Show InChI InChI=1S/C28H50N4O3/c1-2-14-27(34)32-26(23-24-15-17-25(33)18-16-24)28(35)31-22-13-9-12-21-30-20-11-8-6-4-3-5-7-10-19-29/h15-18,26,30,33H,2-14,19-23,29H2,1H3,(H,31,35)(H,32,34)/t26-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
180n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194108
PNG
((S)-N-(1-(2-(6-aminohexylamino)ethylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCNCCCCCCN
Show InChI InChI=1S/C21H36N4O3/c1-2-7-20(27)25-19(16-17-8-10-18(26)11-9-17)21(28)24-15-14-23-13-6-4-3-5-12-22/h8-11,19,23,26H,2-7,12-16,22H2,1H3,(H,24,28)(H,25,27)/t19-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
208n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194107
PNG
((S)-N-(1-(7-(6-aminohexylamino)heptylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCNCCCCCCN
Show InChI InChI=1S/C26H46N4O3/c1-2-12-25(32)30-24(21-22-13-15-23(31)16-14-22)26(33)29-20-11-6-3-5-9-18-28-19-10-7-4-8-17-27/h13-16,24,28,31H,2-12,17-21,27H2,1H3,(H,29,33)(H,30,32)/t24-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
208n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194118
PNG
((S)-N-(1-(5-(3-aminopropylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCN
Show InChI InChI=1S/C21H36N4O3/c1-2-7-20(27)25-19(16-17-8-10-18(26)11-9-17)21(28)24-15-5-3-4-13-23-14-6-12-22/h8-11,19,23,26H,2-7,12-16,22H2,1H3,(H,24,28)(H,25,27)/t19-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
270n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194109
PNG
((S)-N-(1-(5-(8-aminooctylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCN
Show InChI InChI=1S/C26H46N4O3/c1-2-12-25(32)30-24(21-22-13-15-23(31)16-14-22)26(33)29-20-11-7-10-19-28-18-9-6-4-3-5-8-17-27/h13-16,24,28,31H,2-12,17-21,27H2,1H3,(H,29,33)(H,30,32)/t24-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
330n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194125
PNG
((S)-N-(1-(3-(8-aminooctylamino)propylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCNCCCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-17-26-16-8-6-4-3-5-7-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
350n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194115
PNG
((S)-N-(1-(5-(2-aminoethylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCN
Show InChI InChI=1S/C20H34N4O3/c1-2-6-19(26)24-18(15-16-7-9-17(25)10-8-16)20(27)23-13-5-3-4-12-22-14-11-21/h7-10,18,22,25H,2-6,11-15,21H2,1H3,(H,23,27)(H,24,26)/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
410n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194121
PNG
((S)-N-(1-(9-(2-aminoethylamino)nonylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCCNCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-17-9-7-5-3-4-6-8-16-26-18-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
410n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194113
PNG
((S)-N-(1-(5-(4-aminobutylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCN
Show InChI InChI=1S/C22H38N4O3/c1-2-8-21(28)26-20(17-18-9-11-19(27)12-10-18)22(29)25-16-6-3-5-14-24-15-7-4-13-23/h9-12,20,24,27H,2-8,13-17,23H2,1H3,(H,25,29)(H,26,28)/t20-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
450n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194117
PNG
((S)-N-(1-(5-(9-aminononylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCN
Show InChI InChI=1S/C27H48N4O3/c1-2-13-26(33)31-25(22-23-14-16-24(32)17-15-23)27(34)30-21-12-8-11-20-29-19-10-7-5-3-4-6-9-18-28/h14-17,25,29,32H,2-13,18-22,28H2,1H3,(H,30,34)(H,31,33)/t25-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
450n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194123
PNG
((S)-N-(1-(5-(5-aminopentylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCN
Show InChI InChI=1S/C23H40N4O3/c1-2-9-22(29)27-21(18-19-10-12-20(28)13-11-19)23(30)26-17-8-4-7-16-25-15-6-3-5-14-24/h10-13,21,25,28H,2-9,14-18,24H2,1H3,(H,26,30)(H,27,29)/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
460n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194128
PNG
((S)-N-(1-(6-(5-aminopentylamino)hexylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCNCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-4-3-7-16-26-17-8-5-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
468n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194112
PNG
((S)-N-(1-(5-(12-aminododecylamino)pentylamino)-3-(...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCCCCN
Show InChI InChI=1S/C30H54N4O3/c1-2-16-29(36)34-28(25-26-17-19-27(35)20-18-26)30(37)33-24-15-11-14-23-32-22-13-10-8-6-4-3-5-7-9-12-21-31/h17-20,28,32,35H,2-16,21-25,31H2,1H3,(H,33,37)(H,34,36)/t28-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
480n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194124
PNG
((S)-N-(1-(5-(6-aminohexylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-5-8-17-26-16-7-4-3-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
660n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194129
PNG
((S)-N-(1-(6-(6-aminohexylamino)hexylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCNCCCCCCN
Show InChI InChI=1S/C25H44N4O3/c1-2-11-24(31)29-23(20-21-12-14-22(30)15-13-21)25(32)28-19-10-6-5-9-18-27-17-8-4-3-7-16-26/h12-15,23,27,30H,2-11,16-20,26H2,1H3,(H,28,32)(H,29,31)/t23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
685n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194127
PNG
((S)-N-(1-(5-(7-aminoheptylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCN
Show InChI InChI=1S/C25H44N4O3/c1-2-11-24(31)29-23(20-21-12-14-22(30)15-13-21)25(32)28-19-10-6-9-18-27-17-8-5-3-4-7-16-26/h12-15,23,27,30H,2-11,16-20,26H2,1H3,(H,28,32)(H,29,31)/t23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.10E+3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194111
PNG
((S)-N-(1-(5-(10-aminodecylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCCN
Show InChI InChI=1S/C28H50N4O3/c1-2-14-27(34)32-26(23-24-15-17-25(33)18-16-24)28(35)31-22-13-9-12-21-30-20-11-8-6-4-3-5-7-10-19-29/h15-18,26,30,33H,2-14,19-23,29H2,1H3,(H,31,35)(H,32,34)/t26-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.20E+3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194115
PNG
((S)-N-(1-(5-(2-aminoethylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCN
Show InChI InChI=1S/C20H34N4O3/c1-2-6-19(26)24-18(15-16-7-9-17(25)10-8-16)20(27)23-13-5-3-4-12-22-14-11-21/h7-10,18,22,25H,2-6,11-15,21H2,1H3,(H,23,27)(H,24,26)/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.50E+3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194109
PNG
((S)-N-(1-(5-(8-aminooctylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCN
Show InChI InChI=1S/C26H46N4O3/c1-2-12-25(32)30-24(21-22-13-15-23(31)16-14-22)26(33)29-20-11-7-10-19-28-18-9-6-4-3-5-8-17-27/h13-16,24,28,31H,2-12,17-21,27H2,1H3,(H,29,33)(H,30,32)/t24-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
2.30E+3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194112
PNG
((S)-N-(1-(5-(12-aminododecylamino)pentylamino)-3-(...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCCCCN
Show InChI InChI=1S/C30H54N4O3/c1-2-16-29(36)34-28(25-26-17-19-27(35)20-18-26)30(37)33-24-15-11-14-23-32-22-13-10-8-6-4-3-5-7-9-12-21-31/h17-20,28,32,35H,2-16,21-25,31H2,1H3,(H,33,37)(H,34,36)/t28-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
3.10E+3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194117
PNG
((S)-N-(1-(5-(9-aminononylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCN
Show InChI InChI=1S/C27H48N4O3/c1-2-13-26(33)31-25(22-23-14-16-24(32)17-15-23)27(34)30-21-12-8-11-20-29-19-10-7-5-3-4-6-9-18-28/h14-17,25,29,32H,2-13,18-22,28H2,1H3,(H,30,34)(H,31,33)/t25-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
5.00E+3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Cholinesterases


(Homo sapiens (Human))
BDBM50263215
PNG
(CHEMBL473866 | N-[5-(9H-Carbazol-4-yloxy)pentyl]-N...)
Show SMILES Clc1ccc2c(NCCCNCCCCCOc3cccc4[nH]c5ccccc5c34)c3CCCCc3nc2c1
Show InChI InChI=1S/C33H37ClN4O/c34-23-16-17-26-30(22-23)38-28-13-5-3-11-25(28)33(26)36-20-9-19-35-18-6-1-7-21-39-31-15-8-14-29-32(31)24-10-2-4-12-27(24)37-29/h2,4,8,10,12,14-17,22,35,37H,1,3,5-7,9,11,13,18-21H2,(H,36,38)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.54n/an/an/an/an/an/a



UniVersity of Bologna

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AChE by Ellman's method


J Med Chem 51: 4381-4 (2008)


Article DOI: 10.1021/jm800577j
BindingDB Entry DOI: 10.7270/Q21G0M23
More data for this
Ligand-Target Pair
Cholinesterases


(Homo sapiens (Human))
BDBM50263214
PNG
(CHEMBL478667 | N-[4-(9H-Carbazol-4-yloxy)butyl]-N'...)
Show SMILES Clc1ccc2c(NCCCNCCCCOc3cccc4[nH]c5ccccc5c34)c3CCCCc3nc2c1
Show InChI InChI=1S/C32H35ClN4O/c33-22-15-16-25-29(21-22)37-27-12-4-2-10-24(27)32(25)35-19-8-18-34-17-5-6-20-38-30-14-7-13-28-31(30)23-9-1-3-11-26(23)36-28/h1,3,7,9,11,13-16,21,34,36H,2,4-6,8,10,12,17-20H2,(H,35,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.65n/an/an/an/an/an/a



UniVersity of Bologna

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AChE by Ellman's method


J Med Chem 51: 4381-4 (2008)


Article DOI: 10.1021/jm800577j
BindingDB Entry DOI: 10.7270/Q21G0M23
More data for this
Ligand-Target Pair
Cholinesterases


(Homo sapiens (Human))
BDBM50263213
PNG
(CHEMBL478666 | N-[3-(9H-Carbazol-4-yloxy)propyl]-N...)
Show SMILES Clc1ccc2c(NCCCNCCCOc3cccc4[nH]c5ccccc5c34)c3CCCCc3nc2c1
Show InChI InChI=1S/C31H33ClN4O/c32-21-14-15-24-28(20-21)36-26-11-4-2-9-23(26)31(24)34-18-6-16-33-17-7-19-37-29-13-5-12-27-30(29)22-8-1-3-10-25(22)35-27/h1,3,5,8,10,12-15,20,33,35H,2,4,6-7,9,11,16-19H2,(H,34,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.15n/an/an/an/an/an/a



UniVersity of Bologna

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AChE by Ellman's method


J Med Chem 51: 4381-4 (2008)


Article DOI: 10.1021/jm800577j
BindingDB Entry DOI: 10.7270/Q21G0M23
More data for this
Ligand-Target Pair
Cholinesterases


(Homo sapiens (Human))
BDBM50263262
PNG
(CHEMBL474268 | N-[6-(9H-Carbazol-4-yloxy)hexyl]-N'...)
Show SMILES Clc1ccc2c(NCCCNCCCCCCOc3cccc4[nH]c5ccccc5c34)c3CCCCc3nc2c1
Show InChI InChI=1S/C34H39ClN4O/c35-24-17-18-27-31(23-24)39-29-14-6-4-12-26(29)34(27)37-21-10-20-36-19-7-1-2-8-22-40-32-16-9-15-30-33(32)25-11-3-5-13-28(25)38-30/h3,5,9,11,13,15-18,23,36,38H,1-2,4,6-8,10,12,14,19-22H2,(H,37,39)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.57n/an/an/an/an/an/a



UniVersity of Bologna

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AChE by Ellman's method


J Med Chem 51: 4381-4 (2008)


Article DOI: 10.1021/jm800577j
BindingDB Entry DOI: 10.7270/Q21G0M23
More data for this
Ligand-Target Pair
Cholinesterases


(Homo sapiens (Human))
BDBM10514
PNG
(CHEMBL191758 | N-(3-aminopropyl)-6-chloro-1,2,3,4-...)
Show SMILES NCCCNc1c2CCCCc2nc2cc(Cl)ccc12
Show InChI InChI=1S/C16H20ClN3/c17-11-6-7-13-15(10-11)20-14-5-2-1-4-12(14)16(13)19-9-3-8-18/h6-7,10H,1-5,8-9,18H2,(H,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 21.5n/an/an/an/an/an/a



UniVersity of Bologna

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AChE by Ellman's method


J Med Chem 51: 4381-4 (2008)


Article DOI: 10.1021/jm800577j
BindingDB Entry DOI: 10.7270/Q21G0M23
More data for this
Ligand-Target Pair
Cholinesterases


(Homo sapiens (Human))
BDBM8961
PNG
(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Show SMILES Nc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

PDB
Article
PubMed
n/an/a 45.8n/an/an/an/an/an/a



UniVersity of Bologna

Curated by ChEMBL


Assay Description
Inhibition of human serum BChE by Ellman's method


J Med Chem 51: 4381-4 (2008)


Article DOI: 10.1021/jm800577j
BindingDB Entry DOI: 10.7270/Q21G0M23
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cholinesterases


(Homo sapiens (Human))
BDBM50263262
PNG
(CHEMBL474268 | N-[6-(9H-Carbazol-4-yloxy)hexyl]-N'...)
Show SMILES Clc1ccc2c(NCCCNCCCCCCOc3cccc4[nH]c5ccccc5c34)c3CCCCc3nc2c1
Show InChI InChI=1S/C34H39ClN4O/c35-24-17-18-27-31(23-24)39-29-14-6-4-12-26(29)34(27)37-21-10-20-36-19-7-1-2-8-22-40-32-16-9-15-30-33(32)25-11-3-5-13-28(25)38-30/h3,5,9,11,13,15-18,23,36,38H,1-2,4,6-8,10,12,14,19-22H2,(H,37,39)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 137n/an/an/an/an/an/a



UniVersity of Bologna

Curated by ChEMBL


Assay Description
Inhibition of human serum BChE by Ellman's method


J Med Chem 51: 4381-4 (2008)


Article DOI: 10.1021/jm800577j
BindingDB Entry DOI: 10.7270/Q21G0M23
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 72 total )  |  Next  |  Last  >>
Jump to: