new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1148 hits with Last Name = 'miller' and Initial = 'kj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125155
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(6bR,10aS)-1,2,6b,9,...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3OCCN2c13
Show InChI InChI=1S/C23H26FN3O2/c24-15-6-7-17(19(25)13-15)21(28)4-2-9-26-10-8-20-18(14-26)16-3-1-5-22-23(16)27(20)11-12-29-22/h1,3,5-7,13,18,20H,2,4,8-12,14,25H2/t18-,20-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
0.200n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125161
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(6bR,10aS)-1,2,6b,9,...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCN2c13
Show InChI InChI=1S/C23H26FN3OS/c24-15-6-7-17(19(25)13-15)21(28)4-2-9-26-10-8-20-18(14-26)16-3-1-5-22-23(16)27(20)11-12-29-22/h1,3,5-7,13,18,20H,2,4,8-12,14,25H2/t18-,20-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
0.300n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125173
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(7bS,11aR)-6,7,8,9,1...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C24H28FN3OS/c25-16-7-8-18(20(26)14-16)22(29)5-2-10-27-12-9-21-19(15-27)17-4-1-6-23-24(17)28(21)11-3-13-30-23/h1,4,6-8,14,19,21H,2-3,5,9-13,15,26H2/t19-,21-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
0.400n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125154
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(7aS,11aR)-5,6,8,9,1...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3CCCN2c13
Show InChI InChI=1S/C24H28FN3O/c25-17-8-9-19(21(26)14-17)23(29)7-3-11-27-13-10-22-20(15-27)18-6-1-4-16-5-2-12-28(22)24(16)18/h1,4,6,8-9,14,20,22H,2-3,5,7,10-13,15,26H2/t20-,22-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
0.5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125174
PNG
(1-(2-Amino-phenyl)-4-(7bS,11aR)-6,7,8,9,11,11a-hex...)
Show SMILES Nc1ccccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C24H29N3OS/c25-20-8-2-1-6-18(20)22(28)9-4-12-26-14-11-21-19(16-26)17-7-3-10-23-24(17)27(21)13-5-15-29-23/h1-3,6-8,10,19,21H,4-5,9,11-16,25H2/t19-,21-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
0.600n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125170
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(7bS,11aR)-4,5,6,7,8...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3CCCCN2c13
Show InChI InChI=1S/C25H30FN3O/c26-18-9-10-20(22(27)15-18)24(30)8-4-12-28-14-11-23-21(16-28)19-7-3-6-17-5-1-2-13-29(23)25(17)19/h3,6-7,9-10,15,21,23H,1-2,4-5,8,11-14,16,27H2/t21-,23-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
0.600n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125173
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(7bS,11aR)-6,7,8,9,1...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C24H28FN3OS/c25-16-7-8-18(20(26)14-16)22(29)5-2-10-27-12-9-21-19(15-27)17-4-1-6-23-24(17)28(21)11-3-13-30-23/h1,4,6-8,14,19,21H,2-3,5,9-13,15,26H2/t19-,21-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
0.700n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards DA D2 receptor using [3H]-N-methyl-spiperone as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125163
PNG
(1-(2-Amino-phenyl)-4-(7bS,11aR)-4,5,6,7,8,9,11,11a...)
Show SMILES Nc1ccccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3CCCCN2c13
Show InChI InChI=1S/C25H31N3O/c26-22-11-2-1-9-20(22)24(29)12-6-14-27-16-13-23-21(17-27)19-10-5-8-18-7-3-4-15-28(23)25(18)19/h1-2,5,8-11,21,23H,3-4,6-7,12-17,26H2/t21-,23-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
0.700n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM21278
PNG
(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Show SMILES Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1
Show InChI InChI=1S/C22H21Cl3N4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents

DrugBank
Article
PubMed
0.730n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]BMS-725519 from human CB1 receptor expressed in CHO cells after 90 mins by scintillation counting


Bioorg Med Chem Lett 21: 6856-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.016
BindingDB Entry DOI: 10.7270/Q2WS8TN3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125177
PNG
(CHEMBL162768 | N-[5-Fluoro-2-((7bS,11aR)-4-6,7,8,9...)
Show SMILES CC(=O)Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C26H30FN3O2S/c1-17(31)28-22-15-18(27)8-9-20(22)24(32)6-3-11-29-13-10-23-21(16-29)19-5-2-7-25-26(19)30(23)12-4-14-33-25/h2,5,7-9,15,21,23H,3-4,6,10-14,16H2,1H3,(H,28,31)/t21-,23-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
0.800n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125169
PNG
(1-(2-Amino-phenyl)-4-(6bR,10aS)-1,2,6b,9,10,10a-he...)
Show SMILES Nc1ccccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCN2c13
Show InChI InChI=1S/C23H27N3OS/c24-19-7-2-1-5-17(19)21(27)8-4-11-25-12-10-20-18(15-25)16-6-3-9-22-23(16)26(20)13-14-28-22/h1-3,5-7,9,18,20H,4,8,10-15,24H2/t18-,20-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
0.800n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125151
PNG
(1-(2-Amino-phenyl)-4-(7aS,11aR)-5,6,8,9,11,11a-hex...)
Show SMILES Nc1ccccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3CCCN2c13
Show InChI InChI=1S/C24H29N3O/c25-21-10-2-1-8-19(21)23(28)11-5-13-26-15-12-22-20(16-26)18-9-3-6-17-7-4-14-27(22)24(17)18/h1-3,6,8-10,20,22H,4-5,7,11-16,25H2/t20-,22-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
0.800n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125150
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(7bR,11aS)-4,5,6,7,8...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3CCCCN2c13
Show InChI InChI=1S/C25H30FN3O/c26-18-9-10-20(22(27)15-18)24(30)8-4-12-28-14-11-23-21(16-28)19-7-3-6-17-5-1-2-13-29(23)25(17)19/h3,6-7,9-10,15,21,23H,1-2,4-5,8,11-14,16,27H2/t21-,23-/m1/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
0.900n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125164
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(7aR,11aS)-5,6,8,9,1...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3CCCN2c13
Show InChI InChI=1S/C24H28FN3O/c25-17-8-9-19(21(26)14-17)23(29)7-3-11-27-13-10-22-20(15-27)18-6-1-4-16-5-2-12-28(22)24(16)18/h1,4,6,8-9,14,20,22H,2-3,5,7,10-13,15,26H2/t20-,22-/m1/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
1.20n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50161646
PNG
((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)
Show SMILES C[C@H]1CNCCc2ccc(Cl)cc12 |r|
Show InChI InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
1.30n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor (unknown origin)


Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50161646
PNG
((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)
Show SMILES C[C@H]1CNCCc2ccc(Cl)cc12 |r|
Show InChI InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
1.30n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor (unknown origin)


Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125176
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(6bS,10aR)-1,2,6b,9,...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3SCCN2c13
Show InChI InChI=1S/C23H26FN3OS/c24-15-6-7-17(19(25)13-15)21(28)4-2-9-26-10-8-20-18(14-26)16-3-1-5-22-23(16)27(20)11-12-29-22/h1,3,5-7,13,18,20H,2,4,8-12,14,25H2/t18-,20-/m1/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
1.5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125171
PNG
(1-(2-Amino-phenyl)-4-(6bR,10aS)-1,2,6b,9,10,10a-he...)
Show SMILES Nc1ccccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3OCCN2c13
Show InChI InChI=1S/C23H27N3O2/c24-19-7-2-1-5-17(19)21(27)8-4-11-25-12-10-20-18(15-25)16-6-3-9-22-23(16)26(20)13-14-28-22/h1-3,5-7,9,18,20H,4,8,10-15,24H2/t18-,20-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
1.60n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
KEGG

GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
PDB
UniChem
PubMed
2n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity was determined against 5-hydroxytryptamine 1A receptor was determined in male Sprague-Dawley rat brain.


J Med Chem 33: 755-8 (1990)


BindingDB Entry DOI: 10.7270/Q2PG1QPP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125174
PNG
(1-(2-Amino-phenyl)-4-(7bS,11aR)-6,7,8,9,11,11a-hex...)
Show SMILES Nc1ccccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C24H29N3OS/c25-20-8-2-1-6-18(20)22(28)9-4-12-26-14-11-21-19(16-26)17-7-3-10-23-24(17)27(21)13-5-15-29-23/h1-3,6-8,10,19,21H,4-5,9,11-16,25H2/t19-,21-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
2.10n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50125155
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(6bR,10aS)-1,2,6b,9,...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3OCCN2c13
Show InChI InChI=1S/C23H26FN3O2/c24-15-6-7-17(19(25)13-15)21(28)4-2-9-26-10-8-20-18(14-26)16-3-1-5-22-23(16)27(20)11-12-29-22/h1,3,5-7,13,18,20H,2,4,8-12,14,25H2/t18-,20-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
2.30n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards DA D2 receptor using [3H]-N-methyl-spiperone as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50125157
PNG
(1-(2-Amino-4-chloro-phenyl)-4-(7bS,11aR)-6,7,8,9,1...)
Show SMILES Nc1cc(Cl)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C24H28ClN3OS/c25-16-7-8-18(20(26)14-16)22(29)5-2-10-27-12-9-21-19(15-27)17-4-1-6-23-24(17)28(21)11-3-13-30-23/h1,4,6-8,14,19,21H,2-3,5,9-13,15,26H2/t19-,21-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
2.30n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards DA D2 receptor using [3H]-N-methyl-spiperone as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125167
PNG
(1-(4-Fluoro-phenyl)-4-(7bS,11aR)-6,7,8,9,11,11a-he...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C24H27FN2OS/c25-18-9-7-17(8-10-18)22(28)5-2-12-26-14-11-21-20(16-26)19-4-1-6-23-24(19)27(21)13-3-15-29-23/h1,4,6-10,20-21H,2-3,5,11-16H2/t20-,21-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
2.5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50125173
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(7bS,11aR)-6,7,8,9,1...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C24H28FN3OS/c25-16-7-8-18(20(26)14-16)22(29)5-2-10-27-12-9-21-19(15-27)17-4-1-6-23-24(17)28(21)11-3-13-30-23/h1,4,6-8,14,19,21H,2-3,5,9-13,15,26H2/t19-,21-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
2.70n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards DA D2 receptor using [3H]-N-methyl-spiperone as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125172
PNG
(4-(7bS,11aR)-6,7,8,9,11,11a-Hexahydro-5H,7bH-4-thi...)
Show SMILES O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCCN2c13)c1ccccc1
Show InChI InChI=1S/C24H28N2OS/c27-22(18-7-2-1-3-8-18)10-5-13-25-15-12-21-20(17-25)19-9-4-11-23-24(19)26(21)14-6-16-28-23/h1-4,7-9,11,20-21H,5-6,10,12-17H2/t20-,21-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
2.70n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125160
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(6bS,10aR)-1,2,6b,9,...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3OCCN2c13
Show InChI InChI=1S/C23H26FN3O2/c24-15-6-7-17(19(25)13-15)21(28)4-2-9-26-10-8-20-18(14-26)16-3-1-5-22-23(16)27(20)11-12-29-22/h1,3,5-7,13,18,20H,2,4,8-12,14,25H2/t18-,20-/m1/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
2.80n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50309343
PNG
(8-methyl-2,3,4,5,5a,6-hexahydro-[1,4]diazepino[1,7...)
Show SMILES Cc1cccc2N3CCNCCC3NC(=O)c12
Show InChI InChI=1S/C13H17N3O/c1-9-3-2-4-10-12(9)13(17)15-11-5-6-14-7-8-16(10)11/h2-4,11,14H,5-8H2,1H3,(H,15,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
2.90n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Co

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5HT2C receptor expressed in HEK293E cells


Bioorg Med Chem Lett 20: 1128-33 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.014
BindingDB Entry DOI: 10.7270/Q2K074DK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
PDB
UniChem
PubMed
3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenate


J Med Chem 33: 755-8 (1990)


BindingDB Entry DOI: 10.7270/Q2PG1QPP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125179
PNG
(1-(2-Amino-phenyl)-4-(7bR,11aS)-4,5,6,7,8,9,11,11a...)
Show SMILES Nc1ccccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3CCCCN2c13
Show InChI InChI=1S/C25H31N3O/c26-22-11-2-1-9-20(22)24(29)12-6-14-27-16-13-23-21(17-27)19-10-5-8-18-7-3-4-15-28(23)25(18)19/h1-2,5,8-11,21,23H,3-4,6-7,12-17,26H2/t21-,23-/m1/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
3.10n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50125177
PNG
(CHEMBL162768 | N-[5-Fluoro-2-((7bS,11aR)-4-6,7,8,9...)
Show SMILES CC(=O)Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C26H30FN3O2S/c1-17(31)28-22-15-18(27)8-9-20(22)24(32)6-3-11-29-13-10-23-21(16-29)19-5-2-7-25-26(19)30(23)12-4-14-33-25/h2,5,7-9,15,21,23H,3-4,6,10-14,16H2,1H3,(H,28,31)/t21-,23-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
3.40n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards DA D2 receptor using [3H]-N-methyl-spiperone as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50125170
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(7bS,11aR)-4,5,6,7,8...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3CCCCN2c13
Show InChI InChI=1S/C25H30FN3O/c26-18-9-10-20(22(27)15-18)24(30)8-4-12-28-14-11-23-21(16-28)19-7-3-6-17-5-1-2-13-29(23)25(17)19/h3,6-7,9-10,15,21,23H,1-2,4-5,8,11-14,16,27H2/t21-,23-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
3.5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards DA D2 receptor using [3H]-N-methyl-spiperone as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125168
PNG
(1-(2-Amino-phenyl)-4-(7aR,11aS)-5,6,8,9,11,11a-hex...)
Show SMILES Nc1ccccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3CCCN2c13
Show InChI InChI=1S/C24H29N3O/c25-21-10-2-1-8-19(21)23(28)11-5-13-26-15-12-22-20(16-26)18-9-3-6-17-7-4-14-27(22)24(17)18/h1-3,6,8-10,20,22H,4-5,7,11-16,25H2/t20-,22-/m1/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
3.70n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50428530
PNG
(CHEMBL2337494)
Show SMILES Cc1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H14N2O/c1-7-3-2-4-8-9-5-13-6-10(9)14-12(15)11(7)8/h2-4,9-10,13H,5-6H2,1H3,(H,14,15)/t9-,10+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
3.90n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis


Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
PDB
UniChem
PubMed
4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity was determined against 5-hydroxytryptamine 1E receptor in human cortical homogenate


J Med Chem 33: 755-8 (1990)


BindingDB Entry DOI: 10.7270/Q2PG1QPP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50125161
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(6bR,10aS)-1,2,6b,9,...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCN2c13
Show InChI InChI=1S/C23H26FN3OS/c24-15-6-7-17(19(25)13-15)21(28)4-2-9-26-10-8-20-18(14-26)16-3-1-5-22-23(16)27(20)11-12-29-22/h1,3,5-7,13,18,20H,2,4,8-12,14,25H2/t18-,20-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards DA D2 receptor using [3H]-N-methyl-spiperone as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50428541
PNG
(CHEMBL2337501)
Show SMILES Cc1ccc2[C@H]3CNC[C@@H]3NC(=O)c2c1Cl |r|
Show InChI InChI=1S/C12H13ClN2O/c1-6-2-3-7-8-4-14-5-9(8)15-12(16)10(7)11(6)13/h2-3,8-9,14H,4-5H2,1H3,(H,15,16)/t8-,9+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis


Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50125173
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(7bS,11aR)-6,7,8,9,1...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C24H28FN3OS/c25-16-7-8-18(20(26)14-16)22(29)5-2-10-27-12-9-21-19(15-27)17-4-1-6-23-24(17)28(21)11-3-13-30-23/h1,4,6-8,14,19,21H,2-3,5,9-13,15,26H2/t19-,21-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
4.10n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125175
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(7bR,11aS)-6,7,8,9,1...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C24H28FN3OS/c25-16-7-8-18(20(26)14-16)22(29)5-2-10-27-12-9-21-19(15-27)17-4-1-6-23-24(17)28(21)11-3-13-30-23/h1,4,6-8,14,19,21H,2-3,5,9-13,15,26H2/t19-,21-/m1/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
4.20n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50125158
PNG
(1-(2-Amino-4-bromo-phenyl)-4-(7bS,11aR)-6,7,8,9,11...)
Show SMILES Nc1cc(Br)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C24H28BrN3OS/c25-16-7-8-18(20(26)14-16)22(29)5-2-10-27-12-9-21-19(15-27)17-4-1-6-23-24(17)28(21)11-3-13-30-23/h1,4,6-8,14,19,21H,2-3,5,9-13,15,26H2/t19-,21-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
4.70n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards DA D2 receptor using [3H]-N-methyl-spiperone as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50125175
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(7bR,11aS)-6,7,8,9,1...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C24H28FN3OS/c25-16-7-8-18(20(26)14-16)22(29)5-2-10-27-12-9-21-19(15-27)17-4-1-6-23-24(17)28(21)11-3-13-30-23/h1,4,6-8,14,19,21H,2-3,5,9-13,15,26H2/t19-,21-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
4.70n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards DA D2 receptor using [3H]-N-methyl-spiperone as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50428541
PNG
(CHEMBL2337501)
Show SMILES Cc1ccc2[C@H]3CNC[C@@H]3NC(=O)c2c1Cl |r|
Show InChI InChI=1S/C12H13ClN2O/c1-6-2-3-7-8-4-14-5-9(8)15-12(16)10(7)11(6)13/h2-3,8-9,14H,4-5H2,1H3,(H,15,16)/t8-,9+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
4.90n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis


Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
PDB
UniChem
PubMed
5n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity was determined against 5-hydroxytryptamine 1B receptor was determined in male Sprague-Dawley rat brain.


J Med Chem 33: 755-8 (1990)


BindingDB Entry DOI: 10.7270/Q2PG1QPP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50125154
PNG
(1-(2-Amino-4-fluoro-phenyl)-4-(7aS,11aR)-5,6,8,9,1...)
Show SMILES Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3CCCN2c13
Show InChI InChI=1S/C24H28FN3O/c25-17-8-9-19(21(26)14-17)23(29)7-3-11-27-13-10-22-20(15-27)18-6-1-4-16-5-2-12-28(22)24(16)18/h1,4,6,8-9,14,20,22H,2-3,5,7,10-13,15,26H2/t20-,22-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
5.20n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards DA D2 receptor using [3H]-N-methyl-spiperone as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50125152
PNG
(1-(2-Amino-phenyl)-4-(7bR,11aS)-6,7,8,9,11,11a-hex...)
Show SMILES Nc1ccccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C24H29N3OS/c25-20-8-2-1-6-18(20)22(28)9-4-12-26-14-11-21-19(16-26)17-7-3-10-23-24(17)27(21)13-5-15-29-23/h1-3,6-8,10,19,21H,4-5,9,11-16,25H2/t19-,21-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
5.90n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards DA D2 receptor using [3H]-N-methyl-spiperone as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50125174
PNG
(1-(2-Amino-phenyl)-4-(7bS,11aR)-6,7,8,9,11,11a-hex...)
Show SMILES Nc1ccccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C24H29N3OS/c25-20-8-2-1-6-18(20)22(28)9-4-12-26-14-11-21-19(16-26)17-7-3-10-23-24(17)27(21)13-5-15-29-23/h1-3,6-8,10,19,21H,4-5,9,11-16,25H2/t19-,21-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
6n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2C receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50309345
PNG
((+)-10-methyl-2,3,4,5,5a,6-hexahydro-[1,4]diazepin...)
Show SMILES Cc1ccc2C(=O)NC3CCNCCN3c2c1
Show InChI InChI=1S/C13H17N3O/c1-9-2-3-10-11(8-9)16-7-6-14-5-4-12(16)15-13(10)17/h2-3,8,12,14H,4-7H2,1H3,(H,15,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
6.5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Co

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5HT2C receptor expressed in HEK293E cells


Bioorg Med Chem Lett 20: 1128-33 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.014
BindingDB Entry DOI: 10.7270/Q2K074DK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125156
PNG
(1-(2-Amino-phenyl)-4-(6bS,10aR)-1,2,6b,9,10,10a-he...)
Show SMILES Nc1ccccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3SCCN2c13
Show InChI InChI=1S/C23H27N3OS/c24-19-7-2-1-5-17(19)21(27)8-4-11-25-12-10-20-18(15-25)16-6-3-9-22-23(16)26(20)13-14-28-22/h1-3,5-7,9,18,20H,4,8,10-15,24H2/t18-,20-/m1/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
6.60n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50205861
PNG
((R)-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino...)
Show SMILES FC(F)(F)c1cccc2[C@@H]3CNCCN3C(=O)c12
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-7-9-6-16-4-5-17(9)11(18)10(7)8/h1-3,9,16H,4-6H2/t9-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
7n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5HT2C expressed in HEK293E cells


J Med Chem 50: 1365-79 (2007)


Article DOI: 10.1021/jm0612968
BindingDB Entry DOI: 10.7270/Q2XP74M8
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125162
PNG
(CHEMBL162102 | N-[5-Fluoro-2-((7bS,11aR)-4-6,7,8,9...)
Show SMILES CS(=O)(=O)Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C25H30FN3O3S2/c1-34(31,32)27-21-15-17(26)8-9-19(21)23(30)6-3-11-28-13-10-22-20(16-28)18-5-2-7-24-25(18)29(22)12-4-14-33-24/h2,5,7-9,15,20,22,27H,3-4,6,10-14,16H2,1H3/t20-,22-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
7.5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50125148
PNG
(1-(2-Amino-3-fluoro-phenyl)-4-(7bS,11aR)-6,7,8,9,1...)
Show SMILES Nc1c(F)cccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3SCCCN2c13
Show InChI InChI=1S/C24H28FN3OS/c25-19-7-1-6-17(23(19)26)21(29)8-3-11-27-13-10-20-18(15-27)16-5-2-9-22-24(16)28(20)12-4-14-30-22/h1-2,5-7,9,18,20H,3-4,8,10-15,26H2/t18-,20-/m0/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
7.60n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand.


Bioorg Med Chem Lett 13: 767-70 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FNW
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 1148 total )  |  Next  |  Last  >>
Jump to: