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Compile Data Set for Download or QSAR

Found 244 hits with Last Name = 'miller' and Initial = 'lj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50265494
PNG
((R)-N-methyl-2-(1-(3-(3-(1-methyl-2-oxo-5-phenyl-2...)
Show SMILES CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 |r,t:38|
Show InChI InChI=1S/C40H50N8O9/c1-41-33(49)24-55-25-34(50)42-19-10-3-4-11-20-43-35(51)26-56-27-36(52)44-21-22-57-30-16-12-15-29(23-30)45-40(54)47-38-39(53)48(2)32-18-9-8-17-31(32)37(46-38)28-13-6-5-7-14-28/h5-9,12-18,23,38H,3-4,10-11,19-22,24-27H2,1-2H3,(H,41,49)(H,42,50)(H,43,51)(H,44,52)(H2,45,47,54)/t38-/m0/s1
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0.0210n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK-26-33 from CCK2R-MOPR (unknown origin) coexpressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cannabinoid receptor 1/Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50265533
PNG
(2-({[(1S,5R,13R,14S,17S)-9,17-dihydroxy-4-methyl-1...)
Show SMILES CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)N[C@H]1CC[C@@]2(O)[C@H]3Cc4cc(O)cc5O[C@@H]1[C@]2(CCN3C)c45 |r|
Show InChI InChI=1S/C30H43N5O9/c1-31-23(37)14-42-15-24(38)32-8-3-4-9-33-25(39)16-43-17-26(40)34-20-5-6-30(41)22-12-18-11-19(36)13-21-27(18)29(30,28(20)44-21)7-10-35(22)2/h11,13,20,22,28,36,41H,3-10,12,14-17H2,1-2H3,(H,31,37)(H,32,38)(H,33,39)(H,34,40)/t20-,22+,28-,29-,30+/m0/s1
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0.0298n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) expressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50265533
PNG
(2-({[(1S,5R,13R,14S,17S)-9,17-dihydroxy-4-methyl-1...)
Show SMILES CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)N[C@H]1CC[C@@]2(O)[C@H]3Cc4cc(O)cc5O[C@@H]1[C@]2(CCN3C)c45 |r|
Show InChI InChI=1S/C30H43N5O9/c1-31-23(37)14-42-15-24(38)32-8-3-4-9-33-25(39)16-43-17-26(40)34-20-5-6-30(41)22-12-18-11-19(36)13-21-27(18)29(30,28(20)44-21)7-10-35(22)2/h11,13,20,22,28,36,41H,3-10,12,14-17H2,1-2H3,(H,31,37)(H,32,38)(H,33,39)(H,34,40)/t20-,22+,28-,29-,30+/m0/s1
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0.0407n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from CCK2R-MOPR (unknown origin) coexpressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50265494
PNG
((R)-N-methyl-2-(1-(3-(3-(1-methyl-2-oxo-5-phenyl-2...)
Show SMILES CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 |r,t:38|
Show InChI InChI=1S/C40H50N8O9/c1-41-33(49)24-55-25-34(50)42-19-10-3-4-11-20-43-35(51)26-56-27-36(52)44-21-22-57-30-16-12-15-29(23-30)45-40(54)47-38-39(53)48(2)32-18-9-8-17-31(32)37(46-38)28-13-6-5-7-14-28/h5-9,12-18,23,38H,3-4,10-11,19-22,24-27H2,1-2H3,(H,41,49)(H,42,50)(H,43,51)(H,44,52)(H2,45,47,54)/t38-/m0/s1
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0.0480n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK-26-33 from CCK2 receptor (unknown origin) expressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50413477
PNG
(CHEMBL475226)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)Nc2cccc(I)c2)C1=O)c1ccccc1 |r,c:9|
Show InChI InChI=1S/C23H19IN4O2/c1-28-19-13-6-5-12-18(19)20(15-8-3-2-4-9-15)26-21(22(28)29)27-23(30)25-17-11-7-10-16(24)14-17/h2-14,21H,1H3,(H2,25,27,30)/t21-/m1/s1
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1n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expresse...


J Med Chem 52: 2138-47 (2009)


Article DOI: 10.1021/jm801439x
BindingDB Entry DOI: 10.7270/Q22B908P
More data for this
Ligand-Target Pair
Motilin


(Homo sapiens (Human))
BDBM85389
PNG
(CAS_52906-92-0 | Motilin)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccccc1)-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#16]-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](-[#8])=O |r|
Show InChI InChI=1S/C120H188N34O35S/c1-9-64(6)97(152-114(184)86-31-22-53-154(86)117(187)96(63(4)5)151-99(169)70(123)56-66-23-12-10-13-24-66)115(185)150-84(57-67-25-14-11-15-26-67)113(183)153-98(65(7)155)116(186)149-83(58-68-32-34-69(156)35-33-68)101(171)135-60-91(161)136-75(39-45-93(163)164)105(175)147-82(55-62(2)3)111(181)145-77(37-43-88(125)158)106(176)140-73(29-20-51-132-119(128)129)103(173)146-80(48-54-190-8)110(180)142-76(36-42-87(124)157)107(177)144-79(41-47-95(167)168)108(178)139-72(28-17-19-50-122)102(172)143-78(40-46-94(165)166)109(179)141-74(30-21-52-133-120(130)131)104(174)148-85(59-90(127)160)112(182)138-71(27-16-18-49-121)100(170)134-61-92(162)137-81(118(188)189)38-44-89(126)159/h10-15,23-26,32-35,62-65,70-86,96-98,155-156H,9,16-22,27-31,36-61,121-123H2,1-8H3,(H2,124,157)(H2,125,158)(H2,126,159)(H2,127,160)(H,134,170)(H,135,171)(H,136,161)(H,137,162)(H,138,182)(H,139,178)(H,140,176)(H,141,179)(H,142,180)(H,143,172)(H,144,177)(H,145,181)(H,146,173)(H,147,175)(H,148,174)(H,149,186)(H,150,185)(H,151,169)(H,152,184)(H,153,183)(H,163,164)(H,165,166)(H,167,168)(H,188,189)(H4,128,129,132)(H4,130,131,133)/t64-,65+,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,96-,97-,98-/m0/s1
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2.30n/an/an/an/an/an/an/an/a



Mayo Clinic in Scottsdale

Curated by PDSP Ki Database




J Pharmacol Exp Ther 313: 1101-8 (2005)


Article DOI: 10.1124/jpet.104.081562
BindingDB Entry DOI: 10.7270/Q28K77N1
More data for this
Ligand-Target Pair
Secretin receptor


(Homo sapiens (Human))
BDBM50327887
PNG
(CHEMBL1255581 | HSDGTFTSELSRLQDSARLQRLLQGLV-NH2)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C(C)C)C(N)=O |r,wU:81.83,129.133,65.72,156.164,48.53,29.33,112.119,12.17,146.148,4.4,95.100,183.186,wD:189.190,76.76,87.91,167.168,137.142,175.180,197.200,123.125,57.61,152.152,37.44,200.203,21.25,104.108,206.207,(111.34,-17.49,;111.34,-19.03,;112.68,-19.8,;110.01,-19.8,;110.01,-21.34,;108.68,-22.1,;107.35,-21.34,;107.35,-19.8,;106.02,-22.1,;104.68,-21.34,;103.34,-22.1,;103.34,-23.64,;102.01,-21.33,;102.01,-19.79,;103.34,-19.03,;103.34,-17.49,;102.02,-16.72,;104.67,-16.72,;100.68,-22.1,;99.34,-21.34,;99.34,-19.8,;98.01,-22.1,;98.01,-23.64,;99.34,-24.41,;99.34,-25.95,;100.67,-23.64,;96.67,-21.34,;95.33,-22.1,;95.33,-23.64,;94,-21.33,;94,-19.79,;95.33,-19.03,;95.33,-17.49,;96.66,-19.79,;92.67,-22.1,;91.34,-21.34,;91.34,-19.8,;90.01,-22.1,;90.01,-23.64,;91.34,-24.41,;91.34,-25.95,;92.67,-26.72,;92.66,-28.26,;91.34,-29.03,;94.01,-29.03,;88.67,-21.34,;87.33,-22.1,;87.33,-23.64,;86,-21.33,;86,-19.79,;87.33,-19.02,;87.33,-17.48,;86.02,-16.72,;88.66,-16.72,;84.68,-22.11,;83.34,-21.35,;83.34,-19.81,;82.01,-22.12,;82.01,-23.66,;83.34,-24.42,;83.34,-25.96,;84.67,-23.66,;80.68,-21.34,;79.33,-22.1,;79.33,-23.64,;78,-21.33,;78,-19.79,;79.33,-19.03,;79.33,-17.49,;80.67,-16.73,;80.66,-15.19,;79.35,-14.42,;82.01,-14.42,;76.68,-22.11,;75.34,-21.35,;75.34,-19.81,;74.01,-22.11,;74.01,-23.65,;72.68,-21.34,;71.34,-22.1,;71.34,-23.64,;70,-21.33,;70,-19.79,;71.36,-19.03,;68.67,-22.11,;67.33,-21.35,;67.33,-19.81,;66,-22.11,;66,-23.65,;67.33,-24.42,;68.68,-23.65,;67.33,-25.96,;64.67,-21.34,;63.33,-22.1,;63.33,-23.64,;62,-21.34,;62,-19.8,;63.33,-19.03,;63.33,-17.49,;62.02,-16.72,;64.66,-16.73,;60.67,-22.1,;59.33,-21.33,;59.33,-19.79,;58,-22.1,;58,-23.64,;59.33,-24.41,;59.33,-25.95,;60.66,-23.64,;56.67,-21.33,;55.33,-22.08,;55.33,-23.62,;54,-21.32,;54,-19.78,;55.33,-19.01,;55.33,-17.47,;56.68,-16.73,;56.65,-15.19,;55.33,-14.43,;58,-14.43,;52.67,-22.1,;51.34,-21.33,;51.34,-19.79,;50,-22.1,;50,-23.64,;51.37,-24.41,;48.67,-21.32,;47.32,-22.06,;47.32,-23.6,;45.99,-21.3,;45.99,-19.76,;47.32,-18.99,;47.32,-17.45,;48.65,-19.76,;44.67,-22.09,;43.33,-21.33,;43.33,-19.79,;42,-22.1,;42,-23.64,;43.33,-24.41,;43.33,-25.95,;42.05,-26.72,;44.66,-26.71,;40.67,-21.31,;39.32,-22.05,;39.32,-23.59,;37.99,-21.28,;37.99,-19.74,;39.38,-18.98,;36.66,-22.06,;35.33,-21.29,;35.33,-19.75,;34,-22.05,;32.66,-21.28,;31.32,-22.03,;31.32,-23.57,;29.99,-21.26,;29.99,-19.72,;31.32,-18.95,;32.63,-19.72,;33.97,-18.95,;33.97,-17.42,;32.63,-16.65,;31.32,-17.42,;28.67,-22.06,;27.32,-21.3,;27.32,-19.76,;26,-22.07,;24.68,-21.27,;23.33,-22.01,;23.33,-23.55,;21.99,-21.24,;20.66,-22.02,;19.33,-21.26,;19.33,-19.72,;18,-22.02,;18,-23.56,;19.33,-24.33,;20.71,-23.57,;19.33,-25.87,;16.68,-21.22,;15.32,-21.95,;15.32,-23.49,;13.99,-21.18,;13.99,-19.64,;15.37,-18.89,;12.66,-21.95,;11.33,-21.18,;11.33,-19.63,;9.99,-21.95,;8.64,-21.17,;9.99,-23.48,;9.07,-24.71,;9.51,-26.17,;8.25,-27.06,;7.01,-26.13,;7.53,-24.68,;26,-23.61,;24.67,-24.38,;27.39,-24.39,;34,-23.59,;32.66,-24.36,;35.35,-24.37,;111.34,-22.1,;111.34,-23.64,;112.68,-21.34,;114.01,-22.11,;114.01,-23.65,;115.34,-24.41,;112.68,-24.41,;115.34,-21.34,;116.67,-22.11,;115.34,-19.8,)|
Show InChI InChI=1S/C129H216N42O42/c1-58(2)40-78(119(206)170-99(64(13)14)102(134)189)149-94(181)51-145-105(192)74(29-33-91(131)178)153-113(200)81(43-61(7)8)161-116(203)82(44-62(9)10)159-108(195)72(27-22-38-143-128(137)138)151-110(197)75(30-34-92(132)179)154-114(201)79(41-59(3)4)157-107(194)71(26-21-37-142-127(135)136)150-103(190)65(15)148-121(208)87(53-172)166-118(205)86(49-98(187)188)163-111(198)76(31-35-93(133)180)155-115(202)80(42-60(5)6)158-109(196)73(28-23-39-144-129(139)140)152-122(209)89(55-174)167-117(204)83(45-63(11)12)160-112(199)77(32-36-96(183)184)156-123(210)90(56-175)168-126(213)101(67(17)177)171-120(207)84(46-68-24-19-18-20-25-68)164-125(212)100(66(16)176)169-95(182)52-146-106(193)85(48-97(185)186)162-124(211)88(54-173)165-104(191)70(130)47-69-50-141-57-147-69/h18-20,24-25,50,57-67,70-90,99-101,172-177H,21-23,26-49,51-56,130H2,1-17H3,(H2,131,178)(H2,132,179)(H2,133,180)(H2,134,189)(H,141,147)(H,145,192)(H,146,193)(H,148,208)(H,149,181)(H,150,190)(H,151,197)(H,152,209)(H,153,200)(H,154,201)(H,155,202)(H,156,210)(H,157,194)(H,158,196)(H,159,195)(H,160,199)(H,161,203)(H,162,211)(H,163,198)(H,164,212)(H,165,191)(H,166,205)(H,167,204)(H,168,213)(H,169,182)(H,170,206)(H,171,207)(H,183,184)(H,185,186)(H,187,188)(H4,135,136,142)(H4,137,138,143)(H4,139,140,144)/t65-,66+,67+,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,99-,100-,101-/m0/s1
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3.5n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysis


Bioorg Med Chem Lett 20: 6040-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.062
BindingDB Entry DOI: 10.7270/Q23778ZG
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50413478
PNG
(CHEMBL515288)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(I)c2)C1=O)c1ccccc1 |r,c:9|
Show InChI InChI=1S/C23H19IN4O2/c1-28-19-13-6-5-12-18(19)20(15-8-3-2-4-9-15)26-21(22(28)29)27-23(30)25-17-11-7-10-16(24)14-17/h2-14,21H,1H3,(H2,25,27,30)/t21-/m0/s1
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3.72n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I](S)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea from human CCK1 receptor express...


J Med Chem 52: 2138-47 (2009)


Article DOI: 10.1021/jm801439x
BindingDB Entry DOI: 10.7270/Q22B908P
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50265490
PNG
(CHEMBL501238 | N-{m-[R(+)-1]Ureaphenoxy}ethyldigly...)
Show SMILES CN1CC[C@]23[C@H]4Oc5cc(O)cc(C[C@@H]1[C@]2(O)CC[C@@H]4NC(=O)COCC(=O)NNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c4ccccc4)c4ccccc4N(C)C2=O)c1)c35 |r,t:54|
Show InChI InChI=1S/C50H55N9O12/c1-58-19-17-49-43-30-21-32(60)24-37(43)71-45(49)35(15-16-50(49,67)38(58)22-30)53-40(62)26-69-28-42(64)57-56-41(63)27-68-25-39(61)51-18-20-70-33-12-8-11-31(23-33)52-48(66)55-46-47(65)59(2)36-14-7-6-13-34(36)44(54-46)29-9-4-3-5-10-29/h3-14,21,23-24,35,38,45-46,60,67H,15-20,22,25-28H2,1-2H3,(H,51,61)(H,53,62)(H,56,63)(H,57,64)(H2,52,55,66)/t35-,38+,45-,46-,49-,50+/m0/s1
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3.90n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from CCK2R-MOPR (unknown origin) coexpressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cannabinoid receptor 1/Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50265491
PNG
(1-{1-Diglycoldiamide-2-[m-(R(+)-1)ureaphenoxy]etha...)
Show SMILES CN1CC[C@]23[C@H]4Oc5cc(O)cc(C[C@@H]1[C@]2(O)CC[C@@H]4NC(=O)COCC(=O)NCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c4ccccc4)c4ccccc4N(C)C2=O)c1)c35 |r,t:56|
Show InChI InChI=1S/C52H59N9O12/c1-60-21-17-51-45-32-23-34(62)26-39(45)73-47(51)37(15-16-52(51,69)40(60)24-32)57-44(66)30-71-28-42(64)54-19-18-53-41(63)27-70-29-43(65)55-20-22-72-35-12-8-11-33(25-35)56-50(68)59-48-49(67)61(2)38-14-7-6-13-36(38)46(58-48)31-9-4-3-5-10-31/h3-14,23,25-26,37,40,47-48,62,69H,15-22,24,27-30H2,1-2H3,(H,53,63)(H,54,64)(H,55,65)(H,57,66)(H2,56,59,68)/t37-,40+,47-,48-,51-,52+/m0/s1
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5.70n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) expressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cannabinoid receptor 1/Mu-type opioid receptor


(Homo sapiens (Human))
BDBM21015
PNG
((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)NCCO
Show InChI InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
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6.70n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) expressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50265491
PNG
(1-{1-Diglycoldiamide-2-[m-(R(+)-1)ureaphenoxy]etha...)
Show SMILES CN1CC[C@]23[C@H]4Oc5cc(O)cc(C[C@@H]1[C@]2(O)CC[C@@H]4NC(=O)COCC(=O)NCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c4ccccc4)c4ccccc4N(C)C2=O)c1)c35 |r,t:56|
Show InChI InChI=1S/C52H59N9O12/c1-60-21-17-51-45-32-23-34(62)26-39(45)73-47(51)37(15-16-52(51,69)40(60)24-32)57-44(66)30-71-28-42(64)54-19-18-53-41(63)27-70-29-43(65)55-20-22-72-35-12-8-11-33(25-35)56-50(68)59-48-49(67)61(2)38-14-7-6-13-36(38)46(58-48)31-9-4-3-5-10-31/h3-14,23,25-26,37,40,47-48,62,69H,15-22,24,27-30H2,1-2H3,(H,53,63)(H,54,64)(H,55,65)(H,57,66)(H2,56,59,68)/t37-,40+,47-,48-,51-,52+/m0/s1
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7.30n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from CCK2R-MOPR (unknown origin) coexpressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cannabinoid receptor 1/Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50265490
PNG
(CHEMBL501238 | N-{m-[R(+)-1]Ureaphenoxy}ethyldigly...)
Show SMILES CN1CC[C@]23[C@H]4Oc5cc(O)cc(C[C@@H]1[C@]2(O)CC[C@@H]4NC(=O)COCC(=O)NNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c4ccccc4)c4ccccc4N(C)C2=O)c1)c35 |r,t:54|
Show InChI InChI=1S/C50H55N9O12/c1-58-19-17-49-43-30-21-32(60)24-37(43)71-45(49)35(15-16-50(49,67)38(58)22-30)53-40(62)26-69-28-42(64)57-56-41(63)27-68-25-39(61)51-18-20-70-33-12-8-11-31(23-33)52-48(66)55-46-47(65)59(2)36-14-7-6-13-34(36)44(54-46)29-9-4-3-5-10-29/h3-14,21,23-24,35,38,45-46,60,67H,15-20,22,25-28H2,1-2H3,(H,51,61)(H,53,62)(H,56,63)(H,57,64)(H2,52,55,66)/t35-,38+,45-,46-,49-,50+/m0/s1
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8.30n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) expressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM21015
PNG
((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)NCCO
Show InChI InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
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11n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from CCK2R-MOPR (unknown origin) coexpressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Secretin receptor


(Homo sapiens (Human))
BDBM50327888
PNG
(CHEMBL1256314)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N1)C(=O)N[C@@H](C(C)C)C(N)=O |r,wU:197.200,177.181,81.83,150.159,65.72,48.53,112.119,29.33,12.17,95.100,4.4,129.138,wD:183.185,146.147,141.141,87.91,76.76,37.44,169.175,191.195,123.125,57.61,161.163,21.25,104.108,206.209,(102.97,-19.16,;102.97,-20.7,;104.3,-21.48,;101.64,-21.48,;101.64,-23.02,;100.31,-23.79,;98.97,-23.02,;98.97,-21.48,;97.64,-23.79,;96.3,-23.02,;94.97,-23.79,;94.97,-25.33,;93.63,-23.02,;93.63,-21.48,;94.97,-20.71,;94.97,-19.17,;93.64,-18.4,;96.3,-18.4,;92.3,-23.79,;90.96,-23.02,;90.96,-21.48,;89.63,-23.79,;89.63,-25.33,;90.96,-26.1,;90.96,-27.64,;92.29,-25.33,;88.29,-23.02,;86.96,-23.79,;86.96,-25.33,;85.62,-23.02,;85.62,-21.48,;86.96,-20.71,;86.96,-19.17,;88.29,-21.48,;84.28,-23.78,;82.95,-23.01,;82.95,-21.47,;81.61,-23.78,;81.61,-25.32,;82.95,-26.09,;82.95,-27.63,;84.28,-28.4,;84.29,-29.94,;82.94,-30.71,;85.62,-30.7,;80.29,-23.01,;78.95,-23.78,;78.95,-25.32,;77.62,-23.01,;77.62,-21.47,;78.95,-20.7,;78.95,-19.16,;77.6,-18.38,;80.29,-18.39,;76.27,-23.77,;74.94,-23,;74.94,-21.46,;73.6,-23.77,;73.6,-25.31,;74.94,-26.08,;74.94,-27.62,;76.27,-25.31,;72.27,-23,;70.94,-23.78,;70.94,-25.32,;69.61,-23.02,;69.61,-21.48,;70.94,-20.7,;70.94,-19.16,;72.27,-18.38,;72.28,-16.84,;70.95,-16.04,;73.61,-16.05,;68.26,-23.77,;66.92,-23.01,;66.92,-21.47,;65.59,-23.78,;65.59,-25.32,;64.26,-23,;62.94,-23.79,;62.94,-25.33,;61.6,-23.02,;61.6,-21.48,;62.92,-20.68,;60.25,-23.77,;58.91,-23.01,;58.91,-21.47,;57.58,-23.78,;57.58,-25.32,;58.91,-26.09,;60.23,-25.29,;58.91,-27.63,;56.24,-23.01,;54.91,-23.78,;54.91,-25.32,;53.57,-23.01,;53.57,-21.47,;54.91,-20.7,;54.91,-19.16,;53.58,-18.39,;56.24,-18.39,;52.24,-23.78,;50.9,-23.01,;50.9,-21.47,;49.57,-23.77,;49.57,-25.31,;50.9,-26.09,;50.9,-27.63,;52.23,-25.31,;48.23,-23.01,;46.89,-23.77,;46.89,-25.31,;45.56,-23,;45.56,-21.46,;46.89,-20.69,;46.89,-19.15,;48.22,-18.38,;48.22,-16.84,;46.89,-16.05,;49.56,-16.06,;44.22,-23.77,;42.89,-23,;42.89,-21.46,;41.55,-23.77,;41.55,-25.31,;42.89,-26.07,;40.22,-22.99,;38.89,-23.76,;38.89,-25.3,;37.56,-22.99,;37.56,-21.45,;38.89,-20.68,;40.22,-21.46,;41.55,-20.68,;41.55,-19.14,;42.89,-18.35,;40.22,-18.37,;38.89,-19.14,;36.22,-23.76,;34.89,-23,;34.89,-21.46,;33.56,-23.76,;33.56,-25.3,;34.89,-26.07,;26.89,-26.07,;25.56,-25.3,;25.56,-23.76,;24.22,-23,;22.89,-23.76,;22.89,-25.3,;21.55,-23,;21.55,-21.46,;22.89,-20.68,;24.21,-21.45,;25.55,-20.68,;25.55,-19.14,;24.21,-18.37,;22.89,-19.14,;20.21,-23.76,;18.87,-23,;18.87,-21.46,;17.54,-23.76,;16.2,-23,;14.86,-23.77,;14.86,-25.31,;13.53,-23,;12.18,-23.76,;10.84,-23,;10.84,-21.46,;9.52,-23.77,;9.52,-25.31,;10.84,-26.08,;12.17,-25.31,;10.84,-27.62,;8.18,-23,;6.85,-23.77,;6.85,-25.31,;5.51,-23,;5.51,-21.46,;6.86,-20.66,;4.17,-23.76,;2.83,-23,;2.83,-21.45,;1.5,-23.76,;.15,-22.99,;1.49,-25.29,;.58,-26.52,;1.01,-27.99,;-.24,-28.87,;-1.48,-27.94,;-.96,-26.49,;17.54,-25.3,;16.2,-26.08,;18.86,-26.05,;26.89,-23,;26.89,-21.46,;28.22,-23.76,;29.56,-23,;29.56,-21.46,;30.9,-20.68,;30.89,-23.76,;30.89,-25.3,;32.22,-23,;102.97,-23.78,;102.97,-25.32,;104.31,-23.02,;105.65,-23.78,;105.65,-25.32,;106.98,-26.1,;104.31,-26.1,;106.98,-23.02,;108.32,-23.79,;106.98,-21.48,)|
Show InChI InChI=1S/C129H208N42O40S2/c1-59(2)39-78(119(204)171-100(64(11)12)102(134)187)149-96(181)50-145-105(190)75(30-33-93(131)178)153-112(197)81(42-62(7)8)159-115(200)82(43-63(9)10)158-108(193)73(24-19-37-143-128(137)138)151-110(195)76(31-34-94(132)179)154-113(198)79(40-60(3)4)156-107(192)72(23-18-36-142-127(135)136)150-103(188)65(13)148-120(205)87(52-172)165-118(203)86(48-99(185)186)162-111(196)77(32-35-95(133)180)155-114(199)80(41-61(5)6)157-109(194)74(25-20-38-144-129(139)140)152-121(206)89(54-174)166-116(201)83(45-68-26-28-70(177)29-27-68)160-124(209)91-56-212-213-57-92(125(210)167-90(55-175)123(208)169-91)168-117(202)84(44-67-21-16-15-17-22-67)163-126(211)101(66(14)176)170-97(182)51-146-106(191)85(47-98(183)184)161-122(207)88(53-173)164-104(189)71(130)46-69-49-141-58-147-69/h15-17,21-22,26-29,49,58-66,71-92,100-101,172-177H,18-20,23-25,30-48,50-57,130H2,1-14H3,(H2,131,178)(H2,132,179)(H2,133,180)(H2,134,187)(H,141,147)(H,145,190)(H,146,191)(H,148,205)(H,149,181)(H,150,188)(H,151,195)(H,152,206)(H,153,197)(H,154,198)(H,155,199)(H,156,192)(H,157,194)(H,158,193)(H,159,200)(H,160,209)(H,161,207)(H,162,196)(H,163,211)(H,164,189)(H,165,203)(H,166,201)(H,167,210)(H,168,202)(H,169,208)(H,170,182)(H,171,204)(H,183,184)(H,185,186)(H4,135,136,142)(H4,137,138,143)(H4,139,140,144)/t65-,66+,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,100-,101-/m0/s1
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11n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysis


Bioorg Med Chem Lett 20: 6040-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.062
BindingDB Entry DOI: 10.7270/Q23778ZG
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50006878
PNG
((R)-1-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2ccc(C)cc2)C1=O)c1ccccc1 |c:9|
Show InChI InChI=1S/C24H22N4O2/c1-16-12-14-18(15-13-16)25-24(30)27-22-23(29)28(2)20-11-7-6-10-19(20)21(26-22)17-8-4-3-5-9-17/h3-15,22H,1-2H3,(H2,25,27,30)/t22-/m0/s1
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14n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK-26-33 from CCK2R-MOPR (unknown origin) coexpressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50265493
PNG
(CHEMBL442943 | N-{m-[R(+)-1]Ureaphenoxy}ethyl-N'-o...)
Show SMILES CN1CC[C@]23[C@H]4Oc5cc(O)cc(C[C@@H]1[C@]2(O)CC[C@@H]4NC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c4ccccc4)c4ccccc4N(C)C2=O)c1)c35 |r,t:45|
Show InChI InChI=1S/C46H49N7O9/c1-52-19-17-45-39-28-21-30(54)24-35(39)62-41(45)33(15-16-46(45,59)36(52)22-28)49-38(56)26-60-25-37(55)47-18-20-61-31-12-8-11-29(23-31)48-44(58)51-42-43(57)53(2)34-14-7-6-13-32(34)40(50-42)27-9-4-3-5-10-27/h3-14,21,23-24,33,36,41-42,54,59H,15-20,22,25-26H2,1-2H3,(H,47,55)(H,49,56)(H2,48,51,58)/t33-,36+,41-,42-,45-,46+/m0/s1
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14.2n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from CCK2R-MOPR (unknown origin) coexpressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50265492
PNG
(1-{1-Diglycoldiamide-6-[m-(R(+)-1)ureaphenoxy]etha...)
Show SMILES CN1CC[C@]23[C@H]4Oc5cc(O)cc(C[C@@H]1[C@]2(O)CC[C@@H]4NC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c4ccccc4)c4ccccc4N(C)C2=O)c1)c35 |r,t:60|
Show InChI InChI=1S/C56H67N9O12/c1-64-25-21-55-49-36-27-38(66)30-43(49)77-51(55)41(19-20-56(55,73)44(64)28-36)61-48(70)34-75-32-46(68)58-23-11-4-3-10-22-57-45(67)31-74-33-47(69)59-24-26-76-39-16-12-15-37(29-39)60-54(72)63-52-53(71)65(2)42-18-9-8-17-40(42)50(62-52)35-13-6-5-7-14-35/h5-9,12-18,27,29-30,41,44,51-52,66,73H,3-4,10-11,19-26,28,31-34H2,1-2H3,(H,57,67)(H,58,68)(H,59,69)(H,61,70)(H2,60,63,72)/t41-,44+,51-,52-,55-,56+/m0/s1
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16.3n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from CCK2R-MOPR (unknown origin) coexpressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50006878
PNG
((R)-1-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2ccc(C)cc2)C1=O)c1ccccc1 |c:9|
Show InChI InChI=1S/C24H22N4O2/c1-16-12-14-18(15-13-16)25-24(30)27-22-23(29)28(2)20-11-7-6-10-19(20)21(26-22)17-8-4-3-5-9-17/h3-15,22H,1-2H3,(H2,25,27,30)/t22-/m0/s1
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18n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK-26-33 from CCK2 receptor (unknown origin) expressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cannabinoid receptor 1/Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50265493
PNG
(CHEMBL442943 | N-{m-[R(+)-1]Ureaphenoxy}ethyl-N'-o...)
Show SMILES CN1CC[C@]23[C@H]4Oc5cc(O)cc(C[C@@H]1[C@]2(O)CC[C@@H]4NC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c4ccccc4)c4ccccc4N(C)C2=O)c1)c35 |r,t:45|
Show InChI InChI=1S/C46H49N7O9/c1-52-19-17-45-39-28-21-30(54)24-35(39)62-41(45)33(15-16-46(45,59)36(52)22-28)49-38(56)26-60-25-37(55)47-18-20-61-31-12-8-11-29(23-31)48-44(58)51-42-43(57)53(2)34-14-7-6-13-32(34)40(50-42)27-9-4-3-5-10-27/h3-14,21,23-24,33,36,41-42,54,59H,15-20,22,25-26H2,1-2H3,(H,47,55)(H,49,56)(H2,48,51,58)/t33-,36+,41-,42-,45-,46+/m0/s1
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24.1n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) expressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50329179
PNG
(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Show SMILES CC(C)N(Cc1ccccc1)C(=O)CN1c2ccccc2-n2c(nnc2-c2ccccc2)[C@H](Cc2c[nH]c3ccccc23)C1=O |r|
Show InChI InChI=1S/C37H34N6O2/c1-25(2)41(23-26-13-5-3-6-14-26)34(44)24-42-32-19-11-12-20-33(32)43-35(27-15-7-4-8-16-27)39-40-36(43)30(37(42)45)21-28-22-38-31-18-10-9-17-29(28)31/h3-20,22,25,30,38H,21,23-24H2,1-2H3/t30-/m0/s1
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25n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter


J Med Chem 58: 9562-77 (2015)


BindingDB Entry DOI: 10.7270/Q29K4D33
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50329179
PNG
(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Show SMILES CC(C)N(Cc1ccccc1)C(=O)CN1c2ccccc2-n2c(nnc2-c2ccccc2)[C@H](Cc2c[nH]c3ccccc23)C1=O |r|
Show InChI InChI=1S/C37H34N6O2/c1-25(2)41(23-26-13-5-3-6-14-26)34(44)24-42-32-19-11-12-20-33(32)43-35(27-15-7-4-8-16-27)39-40-36(43)30(37(42)45)21-28-22-38-31-18-10-9-17-29(28)31/h3-20,22,25,30,38H,21,23-24H2,1-2H3/t30-/m0/s1
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25n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-CCK] from wild-type human CCK1R at allosteric site expressed in CHO cells after 60 mins by scintillation counter


J Med Chem 58: 9562-77 (2015)


BindingDB Entry DOI: 10.7270/Q29K4D33
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50380728
PNG
(CHEMBL2017835)
Show SMILES Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2c3ccccc3-n3c(nnc3-c3ccccc3)[C@H](Cc3n[nH]c4ccccc34)C2=O)c1 |r|
Show InChI InChI=1S/C40H39N7O2/c1-26-20-27(2)22-28(21-26)23-30-14-10-11-19-45(30)37(48)25-46-35-17-8-9-18-36(35)47-38(29-12-4-3-5-13-29)43-44-39(47)32(40(46)49)24-34-31-15-6-7-16-33(31)41-42-34/h3-9,12-13,15-18,20-22,30,32H,10-11,14,19,23-25H2,1-2H3,(H,41,42)/t30-,32+/m1/s1
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29n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-CCK] from wild-type human CCK1R at allosteric site expressed in CHO cells after 60 mins by scintillation counter


J Med Chem 58: 9562-77 (2015)


BindingDB Entry DOI: 10.7270/Q29K4D33
More data for this
Ligand-Target Pair
Cannabinoid receptor 1/Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50265492
PNG
(1-{1-Diglycoldiamide-6-[m-(R(+)-1)ureaphenoxy]etha...)
Show SMILES CN1CC[C@]23[C@H]4Oc5cc(O)cc(C[C@@H]1[C@]2(O)CC[C@@H]4NC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c4ccccc4)c4ccccc4N(C)C2=O)c1)c35 |r,t:60|
Show InChI InChI=1S/C56H67N9O12/c1-64-25-21-55-49-36-27-38(66)30-43(49)77-51(55)41(19-20-56(55,73)44(64)28-36)61-48(70)34-75-32-46(68)58-23-11-4-3-10-22-57-45(67)31-74-33-47(69)59-24-26-76-39-16-12-15-37(29-39)60-54(72)63-52-53(71)65(2)42-18-9-8-17-40(42)50(62-52)35-13-6-5-7-14-35/h5-9,12-18,27,29-30,41,44,51-52,66,73H,3-4,10-11,19-26,28,31-34H2,1-2H3,(H,57,67)(H,58,68)(H,59,69)(H,61,70)(H2,60,63,72)/t41-,44+,51-,52-,55-,56+/m0/s1
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29.4n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) expressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50265491
PNG
(1-{1-Diglycoldiamide-2-[m-(R(+)-1)ureaphenoxy]etha...)
Show SMILES CN1CC[C@]23[C@H]4Oc5cc(O)cc(C[C@@H]1[C@]2(O)CC[C@@H]4NC(=O)COCC(=O)NCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c4ccccc4)c4ccccc4N(C)C2=O)c1)c35 |r,t:56|
Show InChI InChI=1S/C52H59N9O12/c1-60-21-17-51-45-32-23-34(62)26-39(45)73-47(51)37(15-16-52(51,69)40(60)24-32)57-44(66)30-71-28-42(64)54-19-18-53-41(63)27-70-29-43(65)55-20-22-72-35-12-8-11-33(25-35)56-50(68)59-48-49(67)61(2)38-14-7-6-13-36(38)46(58-48)31-9-4-3-5-10-31/h3-14,23,25-26,37,40,47-48,62,69H,15-22,24,27-30H2,1-2H3,(H,53,63)(H,54,64)(H,55,65)(H,57,66)(H2,56,59,68)/t37-,40+,47-,48-,51-,52+/m0/s1
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33n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK-26-33 from CCK2R-MOPR (unknown origin) coexpressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Motilin


(Homo sapiens (Human))
BDBM86675
PNG
(CAS_0 | NSC_0 | [Bpa5,Ile13]Motilin | [L-Bpa5,Ile1...)
Show SMILES [#6]-[#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(cc1)-[#6](=O)-c1ccccc1)-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccccc1)-[#6](-[#6])-[#6])-[#6@@H](-[#6])-[#6]-[#6])-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](-[#6])=[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](-[#8])=O |r,w:127.132|
Show InChI InChI=1S/C129H196N34O35/c1-11-69(7)105(123(193)148-80(43-49-95(133)166)71(9)145-85(46-52-101(172)173)114(184)150-82(31-20-22-56-131)112(182)153-88(48-54-103(176)177)117(187)151-83(32-23-57-141-128(137)138)113(183)156-93(64-98(136)169)120(190)149-81(30-19-21-55-130)110(180)143-66-100(171)147-89(127(197)198)45-51-97(135)168)160-118(188)84(33-24-58-142-129(139)140)152-116(186)87(44-50-96(134)167)154-119(189)90(60-67(3)4)155-115(185)86(47-53-102(174)175)146-99(170)65-144-111(181)91(62-75-37-41-78(165)42-38-75)157-125(195)107(72(10)164)162-121(191)92(63-74-35-39-77(40-36-74)108(178)76-28-17-14-18-29-76)158-124(194)106(70(8)12-2)161-122(192)94-34-25-59-163(94)126(196)104(68(5)6)159-109(179)79(132)61-73-26-15-13-16-27-73/h13-18,26-29,35-42,67-70,72,79-94,104-107,164-165H,11-12,19-25,30-34,43-66,130-132H2,1-10H3,(H2,133,166)(H2,134,167)(H2,135,168)(H2,136,169)(H,143,180)(H,144,181)(H,146,170)(H,147,171)(H,148,193)(H,149,190)(H,150,184)(H,151,187)(H,152,186)(H,153,182)(H,154,189)(H,155,185)(H,156,183)(H,157,195)(H,158,194)(H,159,179)(H,160,188)(H,161,192)(H,162,191)(H,172,173)(H,174,175)(H,176,177)(H,197,198)(H4,137,138,141)(H4,139,140,142)/t69?,70-,72+,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,104-,105-,106-,107-/m0/s1
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50n/an/an/an/an/an/an/an/a



Mayo Clinic in Scottsdale

Curated by PDSP Ki Database




J Pharmacol Exp Ther 313: 1101-8 (2005)


Article DOI: 10.1124/jpet.104.081562
BindingDB Entry DOI: 10.7270/Q28K77N1
More data for this
Ligand-Target Pair
Motilin


(Homo sapiens (Human))
BDBM86675
PNG
(CAS_0 | NSC_0 | [Bpa5,Ile13]Motilin | [L-Bpa5,Ile1...)
Show SMILES [#6]-[#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(cc1)-[#6](=O)-c1ccccc1)-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccccc1)-[#6](-[#6])-[#6])-[#6@@H](-[#6])-[#6]-[#6])-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](-[#6])=[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](-[#8])=O |r,w:127.132|
Show InChI InChI=1S/C129H196N34O35/c1-11-69(7)105(123(193)148-80(43-49-95(133)166)71(9)145-85(46-52-101(172)173)114(184)150-82(31-20-22-56-131)112(182)153-88(48-54-103(176)177)117(187)151-83(32-23-57-141-128(137)138)113(183)156-93(64-98(136)169)120(190)149-81(30-19-21-55-130)110(180)143-66-100(171)147-89(127(197)198)45-51-97(135)168)160-118(188)84(33-24-58-142-129(139)140)152-116(186)87(44-50-96(134)167)154-119(189)90(60-67(3)4)155-115(185)86(47-53-102(174)175)146-99(170)65-144-111(181)91(62-75-37-41-78(165)42-38-75)157-125(195)107(72(10)164)162-121(191)92(63-74-35-39-77(40-36-74)108(178)76-28-17-14-18-29-76)158-124(194)106(70(8)12-2)161-122(192)94-34-25-59-163(94)126(196)104(68(5)6)159-109(179)79(132)61-73-26-15-13-16-27-73/h13-18,26-29,35-42,67-70,72,79-94,104-107,164-165H,11-12,19-25,30-34,43-66,130-132H2,1-10H3,(H2,133,166)(H2,134,167)(H2,135,168)(H2,136,169)(H,143,180)(H,144,181)(H,146,170)(H,147,171)(H,148,193)(H,149,190)(H,150,184)(H,151,187)(H,152,186)(H,153,182)(H,154,189)(H,155,185)(H,156,183)(H,157,195)(H,158,194)(H,159,179)(H,160,188)(H,161,192)(H,162,191)(H,172,173)(H,174,175)(H,176,177)(H,197,198)(H4,137,138,141)(H4,139,140,142)/t69?,70-,72+,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,104-,105-,106-,107-/m0/s1
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50n/an/an/an/an/an/an/an/a



Mayo Clinic in Scottsdale

Curated by PDSP Ki Database




J Pharmacol Exp Ther 313: 1101-8 (2005)


Article DOI: 10.1124/jpet.104.081562
BindingDB Entry DOI: 10.7270/Q28K77N1
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50265490
PNG
(CHEMBL501238 | N-{m-[R(+)-1]Ureaphenoxy}ethyldigly...)
Show SMILES CN1CC[C@]23[C@H]4Oc5cc(O)cc(C[C@@H]1[C@]2(O)CC[C@@H]4NC(=O)COCC(=O)NNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c4ccccc4)c4ccccc4N(C)C2=O)c1)c35 |r,t:54|
Show InChI InChI=1S/C50H55N9O12/c1-58-19-17-49-43-30-21-32(60)24-37(43)71-45(49)35(15-16-50(49,67)38(58)22-30)53-40(62)26-69-28-42(64)57-56-41(63)27-68-25-39(61)51-18-20-70-33-12-8-11-31(23-33)52-48(66)55-46-47(65)59(2)36-14-7-6-13-34(36)44(54-46)29-9-4-3-5-10-29/h3-14,21,23-24,35,38,45-46,60,67H,15-20,22,25-28H2,1-2H3,(H,51,61)(H,53,62)(H,56,63)(H,57,64)(H2,52,55,66)/t35-,38+,45-,46-,49-,50+/m0/s1
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57n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK-26-33 from CCK2R-MOPR (unknown origin) coexpressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50380728
PNG
(CHEMBL2017835)
Show SMILES Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2c3ccccc3-n3c(nnc3-c3ccccc3)[C@H](Cc3n[nH]c4ccccc34)C2=O)c1 |r|
Show InChI InChI=1S/C40H39N7O2/c1-26-20-27(2)22-28(21-26)23-30-14-10-11-19-45(30)37(48)25-46-35-17-8-9-18-36(35)47-38(29-12-4-3-5-13-29)43-44-39(47)32(40(46)49)24-34-31-15-6-7-16-33(31)41-42-34/h3-9,12-13,15-18,20-22,30,32H,10-11,14,19,23-25H2,1-2H3,(H,41,42)/t30-,32+/m1/s1
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69n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter


J Med Chem 58: 9562-77 (2015)


BindingDB Entry DOI: 10.7270/Q29K4D33
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50265491
PNG
(1-{1-Diglycoldiamide-2-[m-(R(+)-1)ureaphenoxy]etha...)
Show SMILES CN1CC[C@]23[C@H]4Oc5cc(O)cc(C[C@@H]1[C@]2(O)CC[C@@H]4NC(=O)COCC(=O)NCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c4ccccc4)c4ccccc4N(C)C2=O)c1)c35 |r,t:56|
Show InChI InChI=1S/C52H59N9O12/c1-60-21-17-51-45-32-23-34(62)26-39(45)73-47(51)37(15-16-52(51,69)40(60)24-32)57-44(66)30-71-28-42(64)54-19-18-53-41(63)27-70-29-43(65)55-20-22-72-35-12-8-11-33(25-35)56-50(68)59-48-49(67)61(2)38-14-7-6-13-36(38)46(58-48)31-9-4-3-5-10-31/h3-14,23,25-26,37,40,47-48,62,69H,15-22,24,27-30H2,1-2H3,(H,53,63)(H,54,64)(H,55,65)(H,57,66)(H2,56,59,68)/t37-,40+,47-,48-,51-,52+/m0/s1
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71n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK-26-33 from CCK2 receptor (unknown origin) expressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50329179
PNG
(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Show SMILES CC(C)N(Cc1ccccc1)C(=O)CN1c2ccccc2-n2c(nnc2-c2ccccc2)[C@H](Cc2c[nH]c3ccccc23)C1=O |r|
Show InChI InChI=1S/C37H34N6O2/c1-25(2)41(23-26-13-5-3-6-14-26)34(44)24-42-32-19-11-12-20-33(32)43-35(27-15-7-4-8-16-27)39-40-36(43)30(37(42)45)21-28-22-38-31-18-10-9-17-29(28)31/h3-20,22,25,30,38H,21,23-24H2,1-2H3/t30-/m0/s1
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71n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter


J Med Chem 58: 9562-77 (2015)


BindingDB Entry DOI: 10.7270/Q29K4D33
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50265492
PNG
(1-{1-Diglycoldiamide-6-[m-(R(+)-1)ureaphenoxy]etha...)
Show SMILES CN1CC[C@]23[C@H]4Oc5cc(O)cc(C[C@@H]1[C@]2(O)CC[C@@H]4NC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c4ccccc4)c4ccccc4N(C)C2=O)c1)c35 |r,t:60|
Show InChI InChI=1S/C56H67N9O12/c1-64-25-21-55-49-36-27-38(66)30-43(49)77-51(55)41(19-20-56(55,73)44(64)28-36)61-48(70)34-75-32-46(68)58-23-11-4-3-10-22-57-45(67)31-74-33-47(69)59-24-26-76-39-16-12-15-37(29-39)60-54(72)63-52-53(71)65(2)42-18-9-8-17-40(42)50(62-52)35-13-6-5-7-14-35/h5-9,12-18,27,29-30,41,44,51-52,66,73H,3-4,10-11,19-26,28,31-34H2,1-2H3,(H,57,67)(H,58,68)(H,59,69)(H,61,70)(H2,60,63,72)/t41-,44+,51-,52-,55-,56+/m0/s1
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77n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK-26-33 from CCK2R-MOPR (unknown origin) coexpressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50329179
PNG
(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Show SMILES CC(C)N(Cc1ccccc1)C(=O)CN1c2ccccc2-n2c(nnc2-c2ccccc2)[C@H](Cc2c[nH]c3ccccc23)C1=O |r|
Show InChI InChI=1S/C37H34N6O2/c1-25(2)41(23-26-13-5-3-6-14-26)34(44)24-42-32-19-11-12-20-33(32)43-35(27-15-7-4-8-16-27)39-40-36(43)30(37(42)45)21-28-22-38-31-18-10-9-17-29(28)31/h3-20,22,25,30,38H,21,23-24H2,1-2H3/t30-/m0/s1
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166n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-BDZ-1] from wild-type human CCK1R at allosteric site expressed in CHO cells after 60 mins by scintillation counter


J Med Chem 58: 9562-77 (2015)


BindingDB Entry DOI: 10.7270/Q29K4D33
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50329179
PNG
(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Show SMILES CC(C)N(Cc1ccccc1)C(=O)CN1c2ccccc2-n2c(nnc2-c2ccccc2)[C@H](Cc2c[nH]c3ccccc23)C1=O |r|
Show InChI InChI=1S/C37H34N6O2/c1-25(2)41(23-26-13-5-3-6-14-26)34(44)24-42-32-19-11-12-20-33(32)43-35(27-15-7-4-8-16-27)39-40-36(43)30(37(42)45)21-28-22-38-31-18-10-9-17-29(28)31/h3-20,22,25,30,38H,21,23-24H2,1-2H3/t30-/m0/s1
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170n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter


J Med Chem 58: 9562-77 (2015)


BindingDB Entry DOI: 10.7270/Q29K4D33
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50413477
PNG
(CHEMBL475226)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)Nc2cccc(I)c2)C1=O)c1ccccc1 |r,c:9|
Show InChI InChI=1S/C23H19IN4O2/c1-28-19-13-6-5-12-18(19)20(15-8-3-2-4-9-15)26-21(22(28)29)27-23(30)25-17-11-7-10-16(24)14-17/h2-14,21H,1H3,(H2,25,27,30)/t21-/m1/s1
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174n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I](S)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea from human CCK1 receptor express...


J Med Chem 52: 2138-47 (2009)


Article DOI: 10.1021/jm801439x
BindingDB Entry DOI: 10.7270/Q22B908P
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50265493
PNG
(CHEMBL442943 | N-{m-[R(+)-1]Ureaphenoxy}ethyl-N'-o...)
Show SMILES CN1CC[C@]23[C@H]4Oc5cc(O)cc(C[C@@H]1[C@]2(O)CC[C@@H]4NC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c4ccccc4)c4ccccc4N(C)C2=O)c1)c35 |r,t:45|
Show InChI InChI=1S/C46H49N7O9/c1-52-19-17-45-39-28-21-30(54)24-35(39)62-41(45)33(15-16-46(45,59)36(52)22-28)49-38(56)26-60-25-37(55)47-18-20-61-31-12-8-11-29(23-31)48-44(58)51-42-43(57)53(2)34-14-7-6-13-32(34)40(50-42)27-9-4-3-5-10-27/h3-14,21,23-24,33,36,41-42,54,59H,15-20,22,25-26H2,1-2H3,(H,47,55)(H,49,56)(H2,48,51,58)/t33-,36+,41-,42-,45-,46+/m0/s1
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210n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK-26-33 from CCK2R-MOPR (unknown origin) coexpressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50380728
PNG
(CHEMBL2017835)
Show SMILES Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2c3ccccc3-n3c(nnc3-c3ccccc3)[C@H](Cc3n[nH]c4ccccc34)C2=O)c1 |r|
Show InChI InChI=1S/C40H39N7O2/c1-26-20-27(2)22-28(21-26)23-30-14-10-11-19-45(30)37(48)25-46-35-17-8-9-18-36(35)47-38(29-12-4-3-5-13-29)43-44-39(47)32(40(46)49)24-34-31-15-6-7-16-33(31)41-42-34/h3-9,12-13,15-18,20-22,30,32H,10-11,14,19,23-25H2,1-2H3,(H,41,42)/t30-,32+/m1/s1
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214n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-CCK] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter


J Med Chem 58: 9562-77 (2015)


BindingDB Entry DOI: 10.7270/Q29K4D33
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50380728
PNG
(CHEMBL2017835)
Show SMILES Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2c3ccccc3-n3c(nnc3-c3ccccc3)[C@H](Cc3n[nH]c4ccccc34)C2=O)c1 |r|
Show InChI InChI=1S/C40H39N7O2/c1-26-20-27(2)22-28(21-26)23-30-14-10-11-19-45(30)37(48)25-46-35-17-8-9-18-36(35)47-38(29-12-4-3-5-13-29)43-44-39(47)32(40(46)49)24-34-31-15-6-7-16-33(31)41-42-34/h3-9,12-13,15-18,20-22,30,32H,10-11,14,19,23-25H2,1-2H3,(H,41,42)/t30-,32+/m1/s1
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214n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter


J Med Chem 58: 9562-77 (2015)


BindingDB Entry DOI: 10.7270/Q29K4D33
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50265493
PNG
(CHEMBL442943 | N-{m-[R(+)-1]Ureaphenoxy}ethyl-N'-o...)
Show SMILES CN1CC[C@]23[C@H]4Oc5cc(O)cc(C[C@@H]1[C@]2(O)CC[C@@H]4NC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c4ccccc4)c4ccccc4N(C)C2=O)c1)c35 |r,t:45|
Show InChI InChI=1S/C46H49N7O9/c1-52-19-17-45-39-28-21-30(54)24-35(39)62-41(45)33(15-16-46(45,59)36(52)22-28)49-38(56)26-60-25-37(55)47-18-20-61-31-12-8-11-29(23-31)48-44(58)51-42-43(57)53(2)34-14-7-6-13-32(34)40(50-42)27-9-4-3-5-10-27/h3-14,21,23-24,33,36,41-42,54,59H,15-20,22,25-26H2,1-2H3,(H,47,55)(H,49,56)(H2,48,51,58)/t33-,36+,41-,42-,45-,46+/m0/s1
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223n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK-26-33 from CCK2 receptor (unknown origin) expressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50265492
PNG
(1-{1-Diglycoldiamide-6-[m-(R(+)-1)ureaphenoxy]etha...)
Show SMILES CN1CC[C@]23[C@H]4Oc5cc(O)cc(C[C@@H]1[C@]2(O)CC[C@@H]4NC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c4ccccc4)c4ccccc4N(C)C2=O)c1)c35 |r,t:60|
Show InChI InChI=1S/C56H67N9O12/c1-64-25-21-55-49-36-27-38(66)30-43(49)77-51(55)41(19-20-56(55,73)44(64)28-36)61-48(70)34-75-32-46(68)58-23-11-4-3-10-22-57-45(67)31-74-33-47(69)59-24-26-76-39-16-12-15-37(29-39)60-54(72)63-52-53(71)65(2)42-18-9-8-17-40(42)50(62-52)35-13-6-5-7-14-35/h5-9,12-18,27,29-30,41,44,51-52,66,73H,3-4,10-11,19-26,28,31-34H2,1-2H3,(H,57,67)(H,58,68)(H,59,69)(H,61,70)(H2,60,63,72)/t41-,44+,51-,52-,55-,56+/m0/s1
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260n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK-26-33 from CCK2 receptor (unknown origin) expressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50329179
PNG
(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Show SMILES CC(C)N(Cc1ccccc1)C(=O)CN1c2ccccc2-n2c(nnc2-c2ccccc2)[C@H](Cc2c[nH]c3ccccc23)C1=O |r|
Show InChI InChI=1S/C37H34N6O2/c1-25(2)41(23-26-13-5-3-6-14-26)34(44)24-42-32-19-11-12-20-33(32)43-35(27-15-7-4-8-16-27)39-40-36(43)30(37(42)45)21-28-22-38-31-18-10-9-17-29(28)31/h3-20,22,25,30,38H,21,23-24H2,1-2H3/t30-/m0/s1
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275n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-CCK] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter


J Med Chem 58: 9562-77 (2015)


BindingDB Entry DOI: 10.7270/Q29K4D33
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50265490
PNG
(CHEMBL501238 | N-{m-[R(+)-1]Ureaphenoxy}ethyldigly...)
Show SMILES CN1CC[C@]23[C@H]4Oc5cc(O)cc(C[C@@H]1[C@]2(O)CC[C@@H]4NC(=O)COCC(=O)NNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c4ccccc4)c4ccccc4N(C)C2=O)c1)c35 |r,t:54|
Show InChI InChI=1S/C50H55N9O12/c1-58-19-17-49-43-30-21-32(60)24-37(43)71-45(49)35(15-16-50(49,67)38(58)22-30)53-40(62)26-69-28-42(64)57-56-41(63)27-68-25-39(61)51-18-20-70-33-12-8-11-31(23-33)52-48(66)55-46-47(65)59(2)36-14-7-6-13-34(36)44(54-46)29-9-4-3-5-10-29/h3-14,21,23-24,35,38,45-46,60,67H,15-20,22,25-28H2,1-2H3,(H,51,61)(H,53,62)(H,56,63)(H,57,64)(H2,52,55,66)/t35-,38+,45-,46-,49-,50+/m0/s1
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356n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of [125I]CCK-26-33 from CCK2 receptor (unknown origin) expressed in CHO cells


J Med Chem 52: 247-58 (2009)


Article DOI: 10.1021/jm800174p
BindingDB Entry DOI: 10.7270/Q22V2FZJ
More data for this
Ligand-Target Pair
Motilin


(Homo sapiens (Human))
BDBM86676
PNG
([D-Bpa5,Ile13]Motilin)
Show SMILES [#6]-[#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-c1ccc(cc1)-[#6](=O)-c1ccccc1)-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccccc1)-[#6](-[#6])-[#6])-[#6@@H](-[#6])-[#6]-[#6])-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](-[#6])=[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](-[#8])=O |r,w:127.132|
Show InChI InChI=1S/C129H196N34O35/c1-11-69(7)105(123(193)148-80(43-49-95(133)166)71(9)145-85(46-52-101(172)173)114(184)150-82(31-20-22-56-131)112(182)153-88(48-54-103(176)177)117(187)151-83(32-23-57-141-128(137)138)113(183)156-93(64-98(136)169)120(190)149-81(30-19-21-55-130)110(180)143-66-100(171)147-89(127(197)198)45-51-97(135)168)160-118(188)84(33-24-58-142-129(139)140)152-116(186)87(44-50-96(134)167)154-119(189)90(60-67(3)4)155-115(185)86(47-53-102(174)175)146-99(170)65-144-111(181)91(62-75-37-41-78(165)42-38-75)157-125(195)107(72(10)164)162-121(191)92(63-74-35-39-77(40-36-74)108(178)76-28-17-14-18-29-76)158-124(194)106(70(8)12-2)161-122(192)94-34-25-59-163(94)126(196)104(68(5)6)159-109(179)79(132)61-73-26-15-13-16-27-73/h13-18,26-29,35-42,67-70,72,79-94,104-107,164-165H,11-12,19-25,30-34,43-66,130-132H2,1-10H3,(H2,133,166)(H2,134,167)(H2,135,168)(H2,136,169)(H,143,180)(H,144,181)(H,146,170)(H,147,171)(H,148,193)(H,149,190)(H,150,184)(H,151,187)(H,152,186)(H,153,182)(H,154,189)(H,155,185)(H,156,183)(H,157,195)(H,158,194)(H,159,179)(H,160,188)(H,161,192)(H,162,191)(H,172,173)(H,174,175)(H,176,177)(H,197,198)(H4,137,138,141)(H4,139,140,142)/t69?,70-,72+,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92+,93-,94-,104-,105-,106-,107-/m0/s1
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420n/an/an/an/an/an/an/an/a



Mayo Clinic in Scottsdale

Curated by PDSP Ki Database




J Pharmacol Exp Ther 313: 1101-8 (2005)


Article DOI: 10.1124/jpet.104.081562
BindingDB Entry DOI: 10.7270/Q28K77N1
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50329179
PNG
(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Show SMILES CC(C)N(Cc1ccccc1)C(=O)CN1c2ccccc2-n2c(nnc2-c2ccccc2)[C@H](Cc2c[nH]c3ccccc23)C1=O |r|
Show InChI InChI=1S/C37H34N6O2/c1-25(2)41(23-26-13-5-3-6-14-26)34(44)24-42-32-19-11-12-20-33(32)43-35(27-15-7-4-8-16-27)39-40-36(43)30(37(42)45)21-28-22-38-31-18-10-9-17-29(28)31/h3-20,22,25,30,38H,21,23-24H2,1-2H3/t30-/m0/s1
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427n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-BDZ-1] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter


J Med Chem 58: 9562-77 (2015)


BindingDB Entry DOI: 10.7270/Q29K4D33
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50413478
PNG
(CHEMBL515288)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(I)c2)C1=O)c1ccccc1 |r,c:9|
Show InChI InChI=1S/C23H19IN4O2/c1-28-19-13-6-5-12-18(19)20(15-8-3-2-4-9-15)26-21(22(28)29)27-23(30)25-17-11-7-10-16(24)14-17/h2-14,21H,1H3,(H2,25,27,30)/t21-/m0/s1
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537n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expresse...


J Med Chem 52: 2138-47 (2009)


Article DOI: 10.1021/jm801439x
BindingDB Entry DOI: 10.7270/Q22B908P
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50380728
PNG
(CHEMBL2017835)
Show SMILES Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2c3ccccc3-n3c(nnc3-c3ccccc3)[C@H](Cc3n[nH]c4ccccc34)C2=O)c1 |r|
Show InChI InChI=1S/C40H39N7O2/c1-26-20-27(2)22-28(21-26)23-30-14-10-11-19-45(30)37(48)25-46-35-17-8-9-18-36(35)47-38(29-12-4-3-5-13-29)43-44-39(47)32(40(46)49)24-34-31-15-6-7-16-33(31)41-42-34/h3-9,12-13,15-18,20-22,30,32H,10-11,14,19,23-25H2,1-2H3,(H,41,42)/t30-,32+/m1/s1
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912n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-BDZ-1] from wild-type human CCK1R at allosteric site expressed in CHO cells after 60 mins by scintillation counter


J Med Chem 58: 9562-77 (2015)


BindingDB Entry DOI: 10.7270/Q29K4D33
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50329179
PNG
(2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4...)
Show SMILES CC(C)N(Cc1ccccc1)C(=O)CN1c2ccccc2-n2c(nnc2-c2ccccc2)[C@H](Cc2c[nH]c3ccccc23)C1=O |r|
Show InChI InChI=1S/C37H34N6O2/c1-25(2)41(23-26-13-5-3-6-14-26)34(44)24-42-32-19-11-12-20-33(32)43-35(27-15-7-4-8-16-27)39-40-36(43)30(37(42)45)21-28-22-38-31-18-10-9-17-29(28)31/h3-20,22,25,30,38H,21,23-24H2,1-2H3/t30-/m0/s1
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<1.00E+3n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter


J Med Chem 58: 9562-77 (2015)


BindingDB Entry DOI: 10.7270/Q29K4D33
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50380728
PNG
(CHEMBL2017835)
Show SMILES Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2c3ccccc3-n3c(nnc3-c3ccccc3)[C@H](Cc3n[nH]c4ccccc34)C2=O)c1 |r|
Show InChI InChI=1S/C40H39N7O2/c1-26-20-27(2)22-28(21-26)23-30-14-10-11-19-45(30)37(48)25-46-35-17-8-9-18-36(35)47-38(29-12-4-3-5-13-29)43-44-39(47)32(40(46)49)24-34-31-15-6-7-16-33(31)41-42-34/h3-9,12-13,15-18,20-22,30,32H,10-11,14,19,23-25H2,1-2H3,(H,41,42)/t30-,32+/m1/s1
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<1.00E+3n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-BDZ-1] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter


J Med Chem 58: 9562-77 (2015)


BindingDB Entry DOI: 10.7270/Q29K4D33
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50380728
PNG
(CHEMBL2017835)
Show SMILES Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2c3ccccc3-n3c(nnc3-c3ccccc3)[C@H](Cc3n[nH]c4ccccc34)C2=O)c1 |r|
Show InChI InChI=1S/C40H39N7O2/c1-26-20-27(2)22-28(21-26)23-30-14-10-11-19-45(30)37(48)25-46-35-17-8-9-18-36(35)47-38(29-12-4-3-5-13-29)43-44-39(47)32(40(46)49)24-34-31-15-6-7-16-33(31)41-42-34/h3-9,12-13,15-18,20-22,30,32H,10-11,14,19,23-25H2,1-2H3,(H,41,42)/t30-,32+/m1/s1
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1.26E+3n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter


J Med Chem 58: 9562-77 (2015)


BindingDB Entry DOI: 10.7270/Q29K4D33
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50380728
PNG
(CHEMBL2017835)
Show SMILES Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2c3ccccc3-n3c(nnc3-c3ccccc3)[C@H](Cc3n[nH]c4ccccc34)C2=O)c1 |r|
Show InChI InChI=1S/C40H39N7O2/c1-26-20-27(2)22-28(21-26)23-30-14-10-11-19-45(30)37(48)25-46-35-17-8-9-18-36(35)47-38(29-12-4-3-5-13-29)43-44-39(47)32(40(46)49)24-34-31-15-6-7-16-33(31)41-42-34/h3-9,12-13,15-18,20-22,30,32H,10-11,14,19,23-25H2,1-2H3,(H,41,42)/t30-,32+/m1/s1
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1.41E+3n/an/an/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter


J Med Chem 58: 9562-77 (2015)


BindingDB Entry DOI: 10.7270/Q29K4D33
More data for this
Ligand-Target Pair
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