new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 409 hits with Last Name = 'mohr' and Initial = 'pj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase ERK2


(Homo sapiens (Human))
BDBM193676
PNG
(US9670208, Example 295 4-(3-(cyclopropylmethyl)-[1...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(CC3CC3)nnc2c1
Show InChI InChI=1S/C19H19N7/c1-25-17(5-8-21-25)22-16-11-14(4-7-20-16)15-6-9-26-18(10-13-2-3-13)23-24-19(26)12-15/h4-9,11-13H,2-3,10H2,1H3,(H,20,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.400n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM193385
PNG
(US9670208, Example 57)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(Cc3cccc(Cl)c3Cl)nnc2c1
Show InChI InChI=1S/C21H16Cl2N8/c1-30-17(6-9-25-30)27-21-24-8-5-16(26-21)13-7-10-31-18(11-13)28-29-19(31)12-14-3-2-4-15(22)20(14)23/h2-11H,12H2,1H3,(H,24,26,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.5n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192361
PNG
(US9187462, I-41)
Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(OC(F)F)cc1 |r|
Show InChI InChI=1/C26H26F2N6O3/c1-34-15-19(14-30-34)23(16-4-6-21(7-5-16)37-25(27)28)33-24(35)17-2-3-18-13-29-26(32-22(18)12-17)31-20-8-10-36-11-9-20/h2-7,12-15,20,23,25H,8-11H2,1H3,(H,33,35)(H,29,31,32)/t23-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.550n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM180948
PNG
(US9133187, I-59)
Show SMILES Fc1ccc(cc1Cl)[C@@H](CC#N)NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1 |r|
Show InChI InChI=1/C22H24ClFN6O2/c23-17-11-14(1-2-18(17)24)19(3-7-25)29-22(31)30-8-4-15-12-26-21(28-20(15)13-30)27-16-5-9-32-10-6-16/h1-2,11-12,16,19H,3-6,8-10,13H2,(H,29,31)(H,26,27,28)/t19-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/a7.3n/a



ARRAY BIOPHARMA INC.; GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9133187 (2015)


BindingDB Entry DOI: 10.7270/Q28W3C2N
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM193773
PNG
(US9670208, Example 402 4-(3-(4-fluorobenzyl)-[1,2,...)
Show SMILES Fc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(NC3CCOCC3)n2)cc1
Show InChI InChI=1S/C22H21FN6O/c23-17-3-1-15(2-4-17)13-20-27-28-21-14-16(6-10-29(20)21)19-5-9-24-22(26-19)25-18-7-11-30-12-8-18/h1-6,9-10,14,18H,7-8,11-13H2,(H,24,25,26)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM193675
PNG
(US9670208, Example 279 N-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(CC(C)(C)C)nnc2c1
Show InChI InChI=1S/C20H23N7/c1-20(2,3)13-19-25-24-18-12-15(7-10-27(18)19)14-5-8-21-16(11-14)23-17-6-9-22-26(17)4/h5-12H,13H2,1-4H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192386
PNG
(US9187462, I-66)
Show SMILES COc1ccc(cc1Cl)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 |r|
Show InChI InChI=1/C26H26ClFN6O3/c1-34-14-17(12-30-34)24(15-3-4-23(36-2)20(27)9-15)33-25(35)16-10-21(28)19-13-29-26(32-22(19)11-16)31-18-5-7-37-8-6-18/h3-4,9-14,18,24H,5-8H2,1-2H3,(H,33,35)(H,29,31,32)/t24-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192385
PNG
(US9187462, I-65)
Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1ccc(C#N)c(Cl)c1 |r|
Show InChI InChI=1/C26H23ClFN7O2/c1-35-14-18(12-31-35)24(15-2-3-16(11-29)21(27)8-15)34-25(36)17-9-22(28)20-13-30-26(33-23(20)10-17)32-19-4-6-37-7-5-19/h2-3,8-10,12-14,19,24H,4-7H2,1H3,(H,34,36)(H,30,32,33)/t24-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM180995
PNG
(US9133187, II-171)
Show SMILES C[C@@H](CO)Nc1ncc2CCN(Cc2n1)C(=O)N[C@@H]1CNC[C@H]1c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1/C22H27F3N6O2/c1-13(12-32)28-20-27-8-15-6-7-31(11-19(15)29-20)21(33)30-18-10-26-9-17(18)14-2-4-16(5-3-14)22(23,24)25/h2-5,8,13,17-18,26,32H,6-7,9-12H2,1H3,(H,30,33)(H,27,28,29)/t13-,17-,18+/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.700n/an/an/an/a7.3n/a



ARRAY BIOPHARMA INC.; GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9133187 (2015)


BindingDB Entry DOI: 10.7270/Q28W3C2N
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM193381
PNG
(US9670208, Example 49)
Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(Nc3ccnn3C)n2)cc1
Show InChI InChI=1S/C22H20N8O/c1-29-19(8-11-24-29)26-22-23-10-7-18(25-22)16-9-12-30-20(27-28-21(30)14-16)13-15-3-5-17(31-2)6-4-15/h3-12,14H,13H2,1-2H3,(H,23,25,26)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM193781
PNG
(US9670208, Example 493 4-(3-((6-ethoxypyridin-3-yl...)
Show SMILES CCOc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(Nc3ccnn3C)n2)cn1
Show InChI InChI=1S/C22H21N9O/c1-3-32-21-5-4-15(14-24-21)12-19-28-29-20-13-16(8-11-31(19)20)17-6-9-23-22(26-17)27-18-7-10-25-30(18)2/h4-11,13-14H,3,12H2,1-2H3,(H,23,26,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM191370
PNG
(US9670208, Example 35)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(Cc3cc(ccn3)C3CC3)nnc2c1
Show InChI InChI=1S/C23H21N9/c1-31-20(6-10-26-31)28-23-25-9-5-19(27-23)17-7-11-32-21(13-17)29-30-22(32)14-18-12-16(4-8-24-18)15-2-3-15/h4-13,15H,2-3,14H2,1H3,(H,25,27,28)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM193672
PNG
(US9670208, Example 278 4-(3-(pyridin-2-ylmethyl)-[...)
Show SMILES C(c1nnc2cc(ccn12)-c1ccnc(NC2CCOCC2)n1)c1ccccn1
Show InChI InChI=1S/C21H21N7O/c1-2-8-22-17(3-1)14-20-27-26-19-13-15(5-10-28(19)20)18-4-9-23-21(25-18)24-16-6-11-29-12-7-16/h1-5,8-10,13,16H,6-7,11-12,14H2,(H,23,24,25)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM120116
PNG
(US8697715, 209 | US9259470, 209)
Show SMILES Cn1cc(cn1)C(c1ccc(Cl)c(Cl)c1)n1ccc(cc1=O)-c1nc(NC2CCOCC2)ncc1F
Show InChI InChI=1S/C25H23Cl2FN6O2/c1-33-14-17(12-30-33)24(16-2-3-19(26)20(27)10-16)34-7-4-15(11-22(34)35)23-21(28)13-29-25(32-23)31-18-5-8-36-9-6-18/h2-4,7,10-14,18,24H,5-6,8-9H2,1H3,(H,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/a7.3n/a



Array BioPharma, Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US8697715 (2014)


BindingDB Entry DOI: 10.7270/Q2NV9GXF
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM120116
PNG
(US8697715, 209 | US9259470, 209)
Show SMILES Cn1cc(cn1)C(c1ccc(Cl)c(Cl)c1)n1ccc(cc1=O)-c1nc(NC2CCOCC2)ncc1F
Show InChI InChI=1S/C25H23Cl2FN6O2/c1-33-14-17(12-30-33)24(16-2-3-19(26)20(27)10-16)34-7-4-15(11-22(34)35)23-21(28)13-29-25(32-23)31-18-5-8-36-9-6-18/h2-4,7,10-14,18,24H,5-6,8-9H2,1H3,(H,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9259470 (2016)


BindingDB Entry DOI: 10.7270/Q28S4NSQ
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192322
PNG
(US9187462, I-2)
Show SMILES Cn1cc(cn1)C(NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1
Show InChI InChI=1/C25H24ClFN6O2/c1-33-14-18(13-29-33)23(15-4-5-20(26)21(27)10-15)32-24(34)16-2-3-17-12-28-25(31-22(17)11-16)30-19-6-8-35-9-7-19/h2-5,10-14,19,23H,6-9H2,1H3,(H,32,34)(H,28,30,31)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM193396
PNG
(US9670208, Example 121)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(nnc2c1)[C@H](O)Cc1ccccc1 |r|
Show InChI InChI=1/C23H21N7O/c1-29-21(8-11-25-29)26-20-14-17(7-10-24-20)18-9-12-30-22(15-18)27-28-23(30)19(31)13-16-5-3-2-4-6-16/h2-12,14-15,19,31H,13H2,1H3,(H,24,26)/t19-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM193776
PNG
(US9670208, Example 403 4-(3-(3-fluoro-4-methoxyben...)
Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(NC3CCOCC3)n2)cc1F
Show InChI InChI=1S/C23H23FN6O2/c1-31-20-3-2-15(12-18(20)24)13-21-28-29-22-14-16(5-9-30(21)22)19-4-8-25-23(27-19)26-17-6-10-32-11-7-17/h2-5,8-9,12,14,17H,6-7,10-11,13H2,1H3,(H,25,26,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM193756
PNG
(US9670208, Example 317 4-(3-((4,4-difluorocyclohex...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(CC3CCC(F)(F)CC3)nnc2c1
Show InChI InChI=1S/C21H22F2N8/c1-30-17(5-10-25-30)27-20-24-9-4-16(26-20)15-6-11-31-18(28-29-19(31)13-15)12-14-2-7-21(22,23)8-3-14/h4-6,9-11,13-14H,2-3,7-8,12H2,1H3,(H,24,26,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM193412
PNG
(US9670208, Example 276 N-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES Cc1ccnc(Cc2nnc3cc(ccn23)-c2ccnc(Nc3ccnn3C)n2)c1
Show InChI InChI=1S/C21H19N9/c1-14-3-7-22-16(11-14)13-20-28-27-19-12-15(6-10-30(19)20)17-4-8-23-21(25-17)26-18-5-9-24-29(18)2/h3-12H,13H2,1-2H3,(H,23,25,26)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM193410
PNG
(US9670208, Example 272 4-(3-((6-methoxypyridin-3-y...)
Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(NC3CCOCC3)n2)cn1
Show InChI InChI=1S/C22H23N7O2/c1-30-21-3-2-15(14-24-21)12-19-27-28-20-13-16(5-9-29(19)20)18-4-8-23-22(26-18)25-17-6-10-31-11-7-17/h2-5,8-9,13-14,17H,6-7,10-12H2,1H3,(H,23,25,26)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192364
PNG
(US9187462, I-44)
Show SMILES COc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 |r|
Show InChI InChI=1/C26H27ClN6O3/c1-33-15-19(14-29-33)24(16-5-6-23(35-2)21(27)11-16)32-25(34)17-3-4-18-13-28-26(31-22(18)12-17)30-20-7-9-36-10-8-20/h3-6,11-15,20,24H,7-10H2,1-2H3,(H,32,34)(H,28,30,31)/t24-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM180936
PNG
(US9133187, I-16)
Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](CO)c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1/C19H23Cl2N5O2/c1-11(2)23-18-22-8-13-5-6-26(9-16(13)24-18)19(28)25-17(10-27)12-3-4-14(20)15(21)7-12/h3-4,7-8,11,17,27H,5-6,9-10H2,1-2H3,(H,25,28)(H,22,23,24)/t17-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/a7.3n/a



ARRAY BIOPHARMA INC.; GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9133187 (2015)


BindingDB Entry DOI: 10.7270/Q28W3C2N
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM180935
PNG
(US9133187, I-15)
Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)NC([C@H]1CCCN1)c1ccc(c(F)c1)C(F)(F)F |r|
Show InChI InChI=1/C23H28F4N6O/c1-13(2)30-21-29-11-15-7-9-33(12-19(15)31-21)22(34)32-20(18-4-3-8-28-18)14-5-6-16(17(24)10-14)23(25,26)27/h5-6,10-11,13,18,20,28H,3-4,7-9,12H2,1-2H3,(H,32,34)(H,29,30,31)/t18-,20?/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/a7.3n/a



ARRAY BIOPHARMA INC.; GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9133187 (2015)


BindingDB Entry DOI: 10.7270/Q28W3C2N
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM180929
PNG
(US9133187, I-1)
Show SMILES Clc1ccc(cc1Cl)[C@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1cnco1 |r|
Show InChI InChI=1/C23H24Cl2N6O3/c24-17-2-1-14(9-18(17)25)21(20-11-26-13-34-20)30-23(32)31-6-3-15-10-27-22(29-19(15)12-31)28-16-4-7-33-8-5-16/h1-2,9-11,13,16,21H,3-8,12H2,(H,30,32)(H,27,28,29)/t21-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/a7.3n/a



ARRAY BIOPHARMA INC.; GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9133187 (2015)


BindingDB Entry DOI: 10.7270/Q28W3C2N
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192352
PNG
(US9187462, I-32)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 |r|
Show InChI InChI=1/C26H27FN6O3/c1-33-15-19(14-29-33)24(16-5-6-23(35-2)21(27)11-16)32-25(34)17-3-4-18-13-28-26(31-22(18)12-17)30-20-7-9-36-10-8-20/h3-6,11-15,20,24H,7-10H2,1-2H3,(H,32,34)(H,28,30,31)/t24-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192368
PNG
(US9187462, I-48)
Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(C#N)c(Cl)c1 |r|
Show InChI InChI=1/C26H24ClN7O2/c1-34-15-20(14-30-34)24(16-2-4-18(12-28)22(27)10-16)33-25(35)17-3-5-19-13-29-26(32-23(19)11-17)31-21-6-8-36-9-7-21/h2-5,10-11,13-15,21,24H,6-9H2,1H3,(H,33,35)(H,29,31,32)/t24-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192436
PNG
(US9187462, II-46)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cncn1C |r|
Show InChI InChI=1/C26H26F2N6O3/c1-34-14-29-13-22(34)24(15-3-4-23(36-2)20(28)9-15)33-25(35)16-10-19(27)18-12-30-26(32-21(18)11-16)31-17-5-7-37-8-6-17/h3-4,9-14,17,24H,5-8H2,1-2H3,(H,33,35)(H,30,31,32)/t24-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM180942
PNG
(US9133187, I-33)
Show SMILES C[C@@H](CO)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](CCO)c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1/C20H25Cl2N5O3/c1-12(11-29)24-19-23-9-14-4-6-27(10-18(14)25-19)20(30)26-17(5-7-28)13-2-3-15(21)16(22)8-13/h2-3,8-9,12,17,28-29H,4-7,10-11H2,1H3,(H,26,30)(H,23,24,25)/t12-,17+/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/a7.3n/a



ARRAY BIOPHARMA INC.; GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9133187 (2015)


BindingDB Entry DOI: 10.7270/Q28W3C2N
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192403
PNG
(US9187462, II-13)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(N[C@H]3CC[C@H](O)CC3)nc2c1)c1cnn(C)c1 |r,wU:22.22,9.10,wD:25.26,(9.38,1.49,;8.05,2.26,;6.72,1.49,;5.33,2.24,;4,1.47,;4,-.07,;5.33,-.84,;6.67,-.07,;8,-.84,;2.67,-.84,;1.33,-.07,;1.33,1.47,;2.67,2.24,;,2.24,;,3.78,;-1.33,4.55,;-1.33,6.09,;-2.67,3.78,;-4,4.55,;-5.33,3.78,;-5.33,2.24,;-6.67,1.47,;-6.67,-.07,;-5.33,-.84,;-5.33,-2.38,;-6.67,-3.15,;-6.67,-4.69,;-8,-2.38,;-8,-.84,;-4,1.47,;-2.67,2.24,;-1.33,1.47,;2.67,-2.38,;3.91,-3.29,;3.44,-4.75,;1.87,-4.79,;.97,-6.03,;1.42,-3.29,)|
Show InChI InChI=1/C27H28F2N6O3/c1-35-14-17(12-31-35)25(15-3-8-24(38-2)22(29)9-15)34-26(37)16-10-21(28)20-13-30-27(33-23(20)11-16)32-18-4-6-19(36)7-5-18/h3,8-14,18-19,25,36H,4-7H2,1-2H3,(H,34,37)(H,30,32,33)/t18-,19-,25-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192388
PNG
(BDBM192402 | US9187462, I-68)
Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cccc(F)c1 |r|
Show InChI InChI=1/C25H24F2N6O2/c1-33-14-17(12-29-33)23(15-3-2-4-18(26)9-15)32-24(34)16-10-21(27)20-13-28-25(31-22(20)11-16)30-19-5-7-35-8-6-19/h2-4,9-14,19,23H,5-8H2,1H3,(H,32,34)(H,28,30,31)/t23-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192389
PNG
(US9187462, I-69)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(N[C@H]3CC[C@H](O)CC3)nc2c1)c1cnn(C)c1 |r,wU:22.22,wD:9.10,25.26,(11.38,-2.65,;10.05,-3.42,;8.72,-2.65,;7.34,-3.39,;6,-2.62,;6,-1.08,;7.34,-.31,;8.67,-1.08,;10,-.31,;4.67,-.31,;3.33,-1.08,;2,-.31,;2,1.23,;.67,-1.08,;.67,-2.62,;-.67,-3.39,;-.67,-4.93,;-2,-2.62,;-3.33,-3.39,;-4.67,-2.62,;-4.67,-1.08,;-6,-.31,;-7.34,-1.08,;-7.34,-2.62,;-8.67,-3.39,;-10,-2.62,;-11.34,-3.39,;-10,-1.08,;-8.67,-.31,;-3.33,-.31,;-2,-1.08,;-.67,-.31,;4.67,1.23,;3.42,2.13,;3.9,3.6,;5.46,3.63,;6.37,4.88,;5.91,2.13,)|
Show InChI InChI=1/C27H28F2N6O3/c1-35-14-17(12-31-35)25(15-3-8-24(38-2)22(29)9-15)34-26(37)16-10-21(28)20-13-30-27(33-23(20)11-16)32-18-4-6-19(36)7-5-18/h3,8-14,18-19,25,36H,4-7H2,1-2H3,(H,34,37)(H,30,32,33)/t18-,19-,25-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50392791
PNG
(CHEMBL2151321 | US8486966, 1)
Show SMILES CC(C)Oc1cc(n[nH]1)-n1cnc2ccc(N[C@@H](C)c3ccc(F)cn3)nc12 |r|
Show InChI InChI=1S/C19H20FN7O/c1-11(2)28-18-8-17(25-26-18)27-10-22-15-6-7-16(24-19(15)27)23-12(3)14-5-4-13(20)9-21-14/h4-12H,1-3H3,(H,23,24)(H,25,26)/t12-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Abl


ACS Med Chem Lett 3: 705-709 (2012)


Article DOI: 10.1021/ml300074j
BindingDB Entry DOI: 10.7270/Q2GH9K2G
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192359
PNG
(US9187462, I-39)
Show SMILES Fc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@@]1(F)CCNC1 |r|
Show InChI InChI=1/C25H26ClF2N5O2/c26-19-11-15(3-4-20(19)27)22(25(28)7-8-29-14-25)33-23(34)16-1-2-17-13-30-24(32-21(17)12-16)31-18-5-9-35-10-6-18/h1-4,11-13,18,22,29H,5-10,14H2,(H,33,34)(H,30,31,32)/t22-,25+/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192335
PNG
(US9187462, I-15)
Show SMILES CC(CO)Nc1ncc2ccc(cc2n1)C(=O)N[C@H](c1cnn(C)c1)c1ccc(Cl)c(F)c1 |r|
Show InChI InChI=1/C23H23ClFN6O2/c1-13(34-12-32)28-23-26-9-16-4-3-15(8-20(16)29-23)22(33)30-21(17-10-27-31(2)11-17)14-5-6-18(24)19(25)7-14/h3-11,13,21,32H,12H2,1-2H3,(H,30,33)(H,26,28,29)/t13?,21-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192388
PNG
(BDBM192402 | US9187462, I-68)
Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cccc(F)c1 |r|
Show InChI InChI=1/C25H24F2N6O2/c1-33-14-17(12-29-33)23(15-3-2-4-18(26)9-15)32-24(34)16-10-21(27)20-13-28-25(31-22(20)11-16)30-19-5-7-35-8-6-19/h2-4,9-14,19,23H,5-8H2,1H3,(H,32,34)(H,28,30,31)/t23-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192437
PNG
(US9187462, II-47)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnco1 |r|
Show InChI InChI=1/C25H23F2N5O4/c1-34-21-3-2-14(8-19(21)27)23(22-12-28-13-36-22)32-24(33)15-9-18(26)17-11-29-25(31-20(17)10-15)30-16-4-6-35-7-5-16/h2-3,8-13,16,23H,4-7H2,1H3,(H,32,33)(H,29,30,31)/t23-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192438
PNG
(US9187462, II-48)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnnn1C |r|
Show InChI InChI=1/C25H25F2N7O3/c1-34-21(13-29-33-34)23(14-3-4-22(36-2)19(27)9-14)32-24(35)15-10-18(26)17-12-28-25(31-20(17)11-15)30-16-5-7-37-8-6-16/h3-4,9-13,16,23H,5-8H2,1-2H3,(H,32,35)(H,28,30,31)/t23-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50392791
PNG
(CHEMBL2151321 | US8486966, 1)
Show SMILES CC(C)Oc1cc(n[nH]1)-n1cnc2ccc(N[C@@H](C)c3ccc(F)cn3)nc12 |r|
Show InChI InChI=1S/C19H20FN7O/c1-11(2)28-18-8-17(25-26-18)27-10-22-15-6-7-16(24-19(15)27)23-12(3)14-5-4-13(20)9-21-14/h4-12H,1-3H3,(H,23,24)(H,25,26)/t12-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of TrkA


ACS Med Chem Lett 3: 705-709 (2012)


Article DOI: 10.1021/ml300074j
BindingDB Entry DOI: 10.7270/Q2GH9K2G
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM180931
PNG
(US9133187, I-5)
Show SMILES Cn1cc(cn1)C(NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(Cl)c(F)c1
Show InChI InChI=1/C24H27ClFN7O2/c1-32-13-17(12-28-32)22(15-2-3-19(25)20(26)10-15)31-24(34)33-7-4-16-11-27-23(30-21(16)14-33)29-18-5-8-35-9-6-18/h2-3,10-13,18,22H,4-9,14H2,1H3,(H,31,34)(H,27,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/a7.3n/a



ARRAY BIOPHARMA INC.; GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9133187 (2015)


BindingDB Entry DOI: 10.7270/Q28W3C2N
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192332
PNG
(US9187462, I-12)
Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 |r|
Show InChI InChI=1/C25H24ClFN6O2/c1-33-14-18(13-29-33)23(15-4-5-20(26)21(27)10-15)32-24(34)16-2-3-17-12-28-25(31-22(17)11-16)30-19-6-8-35-9-7-19/h2-5,10-14,19,23H,6-9H2,1H3,(H,32,34)(H,28,30,31)/t23-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192342
PNG
(US9187462, I-22)
Show SMILES Cn1ccc(n1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 |r|
Show InChI InChI=1/C25H23ClF2N6O2/c1-34-7-4-21(33-34)23(14-2-3-18(26)20(28)10-14)32-24(35)15-11-19(27)17-13-29-25(31-22(17)12-15)30-16-5-8-36-9-6-16/h2-4,7,10-13,16,23H,5-6,8-9H2,1H3,(H,32,35)(H,29,30,31)/t23-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192367
PNG
(US9187462, I-47)
Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(N[C@@H]3CCO[C@H](CO)C3)nc2c1)c1ccc(Cl)c(F)c1 |r|
Show InChI InChI=1/C26H26ClFN6O3/c1-34-13-18(12-30-34)24(15-4-5-21(27)22(28)8-15)33-25(36)16-2-3-17-11-29-26(32-23(17)9-16)31-19-6-7-37-20(10-19)14-35/h2-5,8-9,11-13,19-20,24,35H,6-7,10,14H2,1H3,(H,33,36)(H,29,31,32)/t19-,20+,24+/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192443
PNG
(US9187462, II-53)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(Nc3ccnn3C)nc2c1)c1cncn1C |r|
Show InChI InChI=1/C25H22F2N8O2/c1-34-13-28-12-20(34)23(14-4-5-21(37-3)18(27)8-14)33-24(36)15-9-17(26)16-11-29-25(31-19(16)10-15)32-22-6-7-30-35(22)2/h4-13,23H,1-3H3,(H,33,36)(H,29,31,32)/t23-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.5n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192353
PNG
(US9187462, I-33)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 |r|
Show InChI InChI=1/C26H26F2N6O3/c1-34-14-17(12-30-34)24(15-3-4-23(36-2)21(28)9-15)33-25(35)16-10-20(27)19-13-29-26(32-22(19)11-16)31-18-5-7-37-8-6-18/h3-4,9-14,18,24H,5-8H2,1-2H3,(H,33,35)(H,29,31,32)/t24-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.5n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM180940
PNG
(US9133187, I-27)
Show SMILES CC[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(OC(F)F)cc1 |r|
Show InChI InChI=1/C23H29F2N5O3/c1-2-19(15-3-5-18(6-4-15)33-21(24)25)29-23(31)30-10-7-16-13-26-22(28-20(16)14-30)27-17-8-11-32-12-9-17/h3-6,13,17,19,21H,2,7-12,14H2,1H3,(H,29,31)(H,26,27,28)/t19-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.5n/an/an/an/a7.3n/a



ARRAY BIOPHARMA INC.; GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9133187 (2015)


BindingDB Entry DOI: 10.7270/Q28W3C2N
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM180932
PNG
(US9133187, I-7)
Show SMILES Fc1cc(ccc1Cl)C(NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1cn[nH]c1
Show InChI InChI=1/C23H25ClFN7O2/c24-18-2-1-14(9-19(18)25)21(16-11-27-28-12-16)31-23(33)32-6-3-15-10-26-22(30-20(15)13-32)29-17-4-7-34-8-5-17/h1-2,9-12,17,21H,3-8,13H2,(H,27,28)(H,31,33)(H,26,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.5n/an/an/an/a7.3n/a



ARRAY BIOPHARMA INC.; GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9133187 (2015)


BindingDB Entry DOI: 10.7270/Q28W3C2N
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM193411
PNG
(US9670208, Example 275 N-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(Cc3cccc(n3)-c3ccccc3)nnc2c1
Show InChI InChI=1S/C26H21N9/c1-34-23(11-14-28-34)31-26-27-13-10-22(30-26)19-12-15-35-24(16-19)32-33-25(35)17-20-8-5-9-21(29-20)18-6-3-2-4-7-18/h2-16H,17H2,1H3,(H,27,30,31)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.5n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM180945
PNG
(US9133187, I-50)
Show SMILES C[C@@H](NC(=O)N1Cc2nc(NC3CCOCC3)ncc2C(F)(F)C1)c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1/C21H23Cl2F2N5O2/c1-12(13-2-3-16(22)17(23)8-13)27-20(31)30-10-18-15(21(24,25)11-30)9-26-19(29-18)28-14-4-6-32-7-5-14/h2-3,8-9,12,14H,4-7,10-11H2,1H3,(H,27,31)(H,26,28,29)/t12-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/a7.3n/a



ARRAY BIOPHARMA INC.; GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9133187 (2015)


BindingDB Entry DOI: 10.7270/Q28W3C2N
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (Human))
BDBM192356
PNG
(US9187462, I-36)
Show SMILES Fc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@]1(F)CCNC1 |r|
Show InChI InChI=1/C25H26ClF2N5O2/c26-19-11-15(3-4-20(19)27)22(25(28)7-8-29-14-25)33-23(34)16-1-2-17-13-30-24(32-21(17)12-16)31-18-5-9-35-10-6-18/h1-4,11-13,18,22,29H,5-10,14H2,(H,33,34)(H,30,31,32)/t22-,25-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 409 total )  |  Next  |  Last  >>
Jump to: