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Compile Data Set for Download or QSAR

Found 1964 hits with Last Name = 'munchhof' and Initial = 'm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424575
PNG
(CHEMBL2312159)
Show SMILES Cc1c(Oc2ccc(cc2F)-n2cnnn2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C |TLB:28:27:24:22.21.20,20:21:29:26.25.24,20:25:29:22.28.21,19:20:29.27.26:24,THB:28:21:29.27.26:24,30:29:24:22.21.20|
Show InChI InChI=1S/C25H29FN8O3/c1-14-22(27-12-28-23(14)36-21-6-5-15(11-20(21)26)32-13-29-30-31-32)33-16-7-18-9-17(33)10-19(8-16)34(18)24(35)37-25(2,3)4/h5-6,11-13,16-19H,7-10H2,1-4H3
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7n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424576
PNG
(CHEMBL2312158)
Show SMILES Cc1c(Oc2ccc(cc2F)-n2cnnn2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1 |TLB:28:27:24:22.21.20,20:21:29:26.25.24,20:25:29:22.28.21,19:20:29.27.26:24,THB:28:21:29.27.26:24,30:29:24:22.21.20|
Show InChI InChI=1S/C25H27FN8O3/c1-14-22(27-12-28-23(14)36-21-4-3-15(11-20(21)26)32-13-29-30-31-32)33-16-7-18-9-17(33)10-19(8-16)34(18)24(35)37-25(2)5-6-25/h3-4,11-13,16-19H,5-10H2,1-2H3
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15n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424564
PNG
(CHEMBL2312506)
Show SMILES CCc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C |TLB:24:23:20:18.17.16,16:17:25:22.21.20,16:21:25:18.24.17,15:16:25.23.22:20,THB:24:17:25.23.22:20,26:25:20:18.17.16|
Show InChI InChI=1S/C25H33N5O3/c1-6-20-22(27-14-28-23(20)32-21-8-7-9-26-15(21)2)29-16-10-18-12-17(29)13-19(11-16)30(18)24(31)33-25(3,4)5/h7-9,14,16-19H,6,10-13H2,1-5H3
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18n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424577
PNG
(CHEMBL2312157)
Show SMILES CC(C)OC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2ccc(cc2F)-n2cnnn2)c1C |TLB:10:9:6.11.12:14,4:6:14:8.9.15,THB:10:11:14:8.9.15,15:9:6:12.13.14,15:13:6:8.10.9,16:15:6.11.12:14|
Show InChI InChI=1S/C24H27FN8O3/c1-13(2)35-24(34)33-18-6-16-7-19(33)9-17(8-18)32(16)22-14(3)23(27-11-26-22)36-21-5-4-15(10-20(21)25)31-12-28-29-30-31/h4-5,10-13,16-19H,6-9H2,1-3H3
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18n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50341310
PNG
(CHEMBL1766082 | Isopropyl 9-anti-({5-Methyl-6-[(2-...)
Show SMILES CC(C)OC(=O)N1CC2COCC(C1)C2Oc1ncnc(Oc2cccnc2C)c1C |TLB:15:14:9.10.11:13.6.7|
Show InChI InChI=1S/C22H28N4O5/c1-13(2)29-22(27)26-8-16-10-28-11-17(9-26)19(16)31-21-14(3)20(24-12-25-21)30-18-6-5-7-23-15(18)4/h5-7,12-13,16-17,19H,8-11H2,1-4H3
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20n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl...


J Med Chem 54: 1948-52 (2011)


Article DOI: 10.1021/jm200003p
BindingDB Entry DOI: 10.7270/Q2CZ37G0
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424579
PNG
(CHEMBL2312156)
Show SMILES Cc1c(Oc2ccc(cc2)-n2cnnn2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C |TLB:27:26:23:21.20.19,19:20:28:25.24.23,19:24:28:21.27.20,18:19:28.26.25:23,THB:27:20:28.26.25:23,29:28:23:21.20.19|
Show InChI InChI=1S/C25H30N8O3/c1-15-22(26-13-27-23(15)35-21-7-5-16(6-8-21)31-14-28-29-30-31)32-17-9-19-11-18(32)12-20(10-17)33(19)24(34)36-25(2,3)4/h5-8,13-14,17-20H,9-12H2,1-4H3
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21n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50341309
PNG
(CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cccnc2C)c1C
Show InChI InChI=1S/C20H26N4O4/c1-13(2)26-20(25)24-10-7-16(8-11-24)27-18-14(3)19(23-12-22-18)28-17-6-5-9-21-15(17)4/h5-6,9,12-13,16H,7-8,10-11H2,1-4H3
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23n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl...


J Med Chem 54: 1948-52 (2011)


Article DOI: 10.1021/jm200003p
BindingDB Entry DOI: 10.7270/Q2CZ37G0
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50341310
PNG
(CHEMBL1766082 | Isopropyl 9-anti-({5-Methyl-6-[(2-...)
Show SMILES CC(C)OC(=O)N1CC2COCC(C1)C2Oc1ncnc(Oc2cccnc2C)c1C |TLB:15:14:9.10.11:13.6.7|
Show InChI InChI=1S/C22H28N4O5/c1-13(2)29-22(27)26-8-16-10-28-11-17(9-26)19(16)31-21-14(3)20(24-12-25-21)30-18-6-5-7-23-15(18)4/h5-7,12-13,16-17,19H,8-11H2,1-4H3
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32n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl...


J Med Chem 54: 1948-52 (2011)


Article DOI: 10.1021/jm200003p
BindingDB Entry DOI: 10.7270/Q2CZ37G0
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50341310
PNG
(CHEMBL1766082 | Isopropyl 9-anti-({5-Methyl-6-[(2-...)
Show SMILES CC(C)OC(=O)N1CC2COCC(C1)C2Oc1ncnc(Oc2cccnc2C)c1C |TLB:15:14:9.10.11:13.6.7|
Show InChI InChI=1S/C22H28N4O5/c1-13(2)29-22(27)26-8-16-10-28-11-17(9-26)19(16)31-21-14(3)20(24-12-25-21)30-18-6-5-7-23-15(18)4/h5-7,12-13,16-17,19H,8-11H2,1-4H3
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33n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl...


J Med Chem 54: 1948-52 (2011)


Article DOI: 10.1021/jm200003p
BindingDB Entry DOI: 10.7270/Q2CZ37G0
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424573
PNG
(CHEMBL2312161)
Show SMILES Cc1c(Oc2ccc(cc2F)-n2cncn2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C |TLB:28:27:24:22.21.20,20:21:29:26.25.24,20:25:29:22.28.21,19:20:29.27.26:24,THB:28:21:29.27.26:24,30:29:24:22.21.20|
Show InChI InChI=1S/C26H30FN7O3/c1-15-23(29-13-30-24(15)36-22-6-5-16(11-21(22)27)32-14-28-12-31-32)33-17-7-19-9-18(33)10-20(8-17)34(19)25(35)37-26(2,3)4/h5-6,11-14,17-20H,7-10H2,1-4H3
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33n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424548
PNG
(CHEMBL2312517)
Show SMILES Cc1c(Oc2ccc(cc2F)S(C)(=O)=O)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C |TLB:27:26:23:21.20.19,19:20:28:25.24.23,19:24:28:21.27.20,18:19:28.26.25:23,THB:27:20:28.26.25:23,29:28:23:21.20.19|
Show InChI InChI=1S/C25H31FN4O5S/c1-14-22(27-13-28-23(14)34-21-7-6-19(12-20(21)26)36(5,32)33)29-15-8-17-10-16(29)11-18(9-15)30(17)24(31)35-25(2,3)4/h6-7,12-13,15-18H,8-11H2,1-5H3
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41n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424580
PNG
(CHEMBL2312516)
Show SMILES Cc1c(Oc2ccc(cc2)-n2cnnn2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1 |TLB:27:26:23:21.20.19,19:20:28:25.24.23,19:24:28:21.27.20,18:19:28.26.25:23,THB:27:20:28.26.25:23,29:28:23:21.20.19|
Show InChI InChI=1S/C25H28N8O3/c1-15-22(26-13-27-23(15)35-21-5-3-16(4-6-21)31-14-28-29-30-31)32-17-9-19-11-18(32)12-20(10-17)33(19)24(34)36-25(2)7-8-25/h3-6,13-14,17-20H,7-12H2,1-2H3
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48n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364541
PNG
(CHEMBL1951011)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(cc2F)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H26FN3O6S/c1-13(2)29-21(26)25-9-7-15(8-10-25)30-19-14(3)20(24-12-23-19)31-18-6-5-16(11-17(18)22)32(4,27)28/h5-6,11-13,15H,7-10H2,1-4H3
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53n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424581
PNG
(CHEMBL2312515)
Show SMILES CC(C)OC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2ccc(cc2)-n2cnnn2)c1C |TLB:10:9:6.11.12:14,4:6:14:8.9.15,THB:10:11:14:8.9.15,15:9:6:12.13.14,15:13:6:8.10.9,16:15:6.11.12:14|
Show InChI InChI=1S/C24H28N8O3/c1-14(2)34-24(33)32-19-8-17-9-20(32)11-18(10-19)31(17)22-15(3)23(26-12-25-22)35-21-6-4-16(5-7-21)30-13-27-28-29-30/h4-7,12-14,17-20H,8-11H2,1-3H3
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94n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424563
PNG
(CHEMBL2312505)
Show SMILES CCc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1 |TLB:24:23:20:18.17.16,16:17:25:22.21.20,16:21:25:18.24.17,15:16:25.23.22:20,THB:24:17:25.23.22:20,26:25:20:18.17.16|
Show InChI InChI=1S/C25H31N5O3/c1-4-20-22(27-14-28-23(20)32-21-6-5-9-26-15(21)2)29-16-10-18-12-17(29)13-19(11-16)30(18)24(31)33-25(3)7-8-25/h5-6,9,14,16-19H,4,7-8,10-13H2,1-3H3
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123n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424578
PNG
(CHEMBL2311545)
Show SMILES Cc1c(Oc2ccc(cc2)-n2cncn2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C |TLB:27:26:23:21.20.19,19:20:28:25.24.23,19:24:28:21.27.20,18:19:28.26.25:23,THB:27:20:28.26.25:23,29:28:23:21.20.19|
Show InChI InChI=1S/C26H31N7O3/c1-16-23(28-14-29-24(16)35-22-7-5-17(6-8-22)31-15-27-13-30-31)32-18-9-20-11-19(32)12-21(10-18)33(20)25(34)36-26(2,3)4/h5-8,13-15,18-21H,9-12H2,1-4H3
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125n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50341310
PNG
(CHEMBL1766082 | Isopropyl 9-anti-({5-Methyl-6-[(2-...)
Show SMILES CC(C)OC(=O)N1CC2COCC(C1)C2Oc1ncnc(Oc2cccnc2C)c1C |TLB:15:14:9.10.11:13.6.7|
Show InChI InChI=1S/C22H28N4O5/c1-13(2)29-22(27)26-8-16-10-28-11-17(9-26)19(16)31-21-14(3)20(24-12-25-21)30-18-6-5-7-23-15(18)4/h5-7,12-13,16-17,19H,8-11H2,1-4H3
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125n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl...


J Med Chem 54: 1948-52 (2011)


Article DOI: 10.1021/jm200003p
BindingDB Entry DOI: 10.7270/Q2CZ37G0
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424550
PNG
(CHEMBL2312519)
Show SMILES Cc1c(Oc2ccc(cc2F)S(C)(=O)=O)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1 |TLB:27:26:23:21.20.19,19:20:28:25.24.23,19:24:28:21.27.20,18:19:28.26.25:23,THB:27:20:28.26.25:23,29:28:23:21.20.19|
Show InChI InChI=1S/C25H29FN4O5S/c1-14-22(27-13-28-23(14)34-21-5-4-19(12-20(21)26)36(3,32)33)29-15-8-17-10-16(29)11-18(9-15)30(17)24(31)35-25(2)6-7-25/h4-5,12-13,15-18H,6-11H2,1-3H3
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131n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424583
PNG
(CHEMBL2312513)
Show SMILES Cc1c(Oc2ccc(cc2F)C#N)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C |TLB:25:24:21:19.18.17,17:18:26:23.22.21,17:22:26:19.25.18,16:17:26.24.23:21,THB:25:18:26.24.23:21,27:26:21:19.18.17|
Show InChI InChI=1S/C25H28FN5O3/c1-14-22(28-13-29-23(14)33-21-6-5-15(12-27)7-20(21)26)30-16-8-18-10-17(30)11-19(9-16)31(18)24(32)34-25(2,3)4/h5-7,13,16-19H,8-11H2,1-4H3
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133n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424559
PNG
(CHEMBL2312528)
Show SMILES Cc1ncccc1Oc1ncnc(N2C3CC4CC2CC(C3)N4C(=O)OC2(C)CCC2)c1C |TLB:21:20:17:15.14.13,13:14:22:19.18.17,13:18:22:15.21.14,12:13:22.20.19:17,THB:21:14:22.20.19:17,23:22:17:15.14.13|
Show InChI InChI=1S/C25H31N5O3/c1-15-22(27-14-28-23(15)32-21-6-4-9-26-16(21)2)29-17-10-19-12-18(29)13-20(11-17)30(19)24(31)33-25(3)7-5-8-25/h4,6,9,14,17-20H,5,7-8,10-13H2,1-3H3
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136n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50341309
PNG
(CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cccnc2C)c1C
Show InChI InChI=1S/C20H26N4O4/c1-13(2)26-20(25)24-10-7-16(8-11-24)27-18-14(3)19(23-12-22-18)28-17-6-5-9-21-15(17)4/h5-6,9,12-13,16H,7-8,10-11H2,1-4H3
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140n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl...


J Med Chem 54: 1948-52 (2011)


Article DOI: 10.1021/jm200003p
BindingDB Entry DOI: 10.7270/Q2CZ37G0
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424549
PNG
(CHEMBL2312518)
Show SMILES CC(C)OC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2ccc(cc2F)S(C)(=O)=O)c1C |TLB:10:9:6.11.12:14,4:6:14:8.9.15,THB:10:11:14:8.9.15,15:9:6:12.13.14,15:13:6:8.10.9,16:15:6.11.12:14|
Show InChI InChI=1S/C24H29FN4O5S/c1-13(2)33-24(30)29-17-7-15-8-18(29)10-16(9-17)28(15)22-14(3)23(27-12-26-22)34-21-6-5-19(11-20(21)25)35(4,31)32/h5-6,11-13,15-18H,7-10H2,1-4H3
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141n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424569
PNG
(CHEMBL2312511)
Show SMILES COc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C |TLB:24:23:20:18.17.16,16:17:25:22.21.20,16:21:25:18.24.17,15:16:25.23.22:20,THB:24:17:25.23.22:20,26:25:20:18.17.16|
Show InChI InChI=1S/C24H31N5O4/c1-14-19(7-6-8-25-14)32-22-20(31-5)21(26-13-27-22)28-15-9-17-11-16(28)12-18(10-15)29(17)23(30)33-24(2,3)4/h6-8,13,15-18H,9-12H2,1-5H3
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163n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424562
PNG
(CHEMBL2312504)
Show SMILES CCc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)C |TLB:24:23:20:18.17.16,16:17:25:22.21.20,16:21:25:18.24.17,15:16:25.23.22:20,THB:24:17:25.23.22:20,26:25:20:18.17.16|
Show InChI InChI=1S/C24H31N5O3/c1-5-20-22(26-13-27-23(20)32-21-7-6-8-25-15(21)4)28-16-9-18-11-17(28)12-19(10-16)29(18)24(30)31-14(2)3/h6-8,13-14,16-19H,5,9-12H2,1-4H3
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197n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424555
PNG
(CHEMBL2312525)
Show SMILES CC(C)COC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2cccnc2C)c1C |TLB:11:10:7.12.13:15,5:7:15:9.10.16,THB:11:12:15:9.10.16,16:10:7:13.14.15,16:14:7:9.11.10,17:16:7.12.13:15|
Show InChI InChI=1S/C24H31N5O3/c1-14(2)12-31-24(30)29-19-8-17-9-20(29)11-18(10-19)28(17)22-15(3)23(27-13-26-22)32-21-6-5-7-25-16(21)4/h5-7,13-14,17-20H,8-12H2,1-4H3
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231n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424552
PNG
(CHEMBL2312526)
Show SMILES CC[C@@H](C)OC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2cccnc2C)c1C |r,TLB:11:10:7.12.13:15,5:7:15:9.10.16,THB:11:12:15:9.10.16,16:10:7:13.14.15,16:14:7:9.11.10,17:16:7.12.13:15|
Show InChI InChI=1S/C24H31N5O3/c1-5-14(2)31-24(30)29-19-9-17-10-20(29)12-18(11-19)28(17)22-15(3)23(27-13-26-22)32-21-7-6-8-25-16(21)4/h6-8,13-14,17-20H,5,9-12H2,1-4H3/t14-,17?,18?,19?,20?/m1/s1
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290n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424582
PNG
(CHEMBL2312514)
Show SMILES CC(C)OC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2ccc(cc2)-n2ccnn2)c1C |TLB:10:9:6.11.12:14,4:6:14:8.9.15,THB:10:11:14:8.9.15,15:9:6:12.13.14,15:13:6:8.10.9,16:15:6.11.12:14|
Show InChI InChI=1S/C25H29N7O3/c1-15(2)34-25(33)32-20-10-18-11-21(32)13-19(12-20)31(18)23-16(3)24(27-14-26-23)35-22-6-4-17(5-7-22)30-9-8-28-29-30/h4-9,14-15,18-21H,10-13H2,1-3H3
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294n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424558
PNG
(CHEMBL2312524)
Show SMILES Cc1ncccc1Oc1ncnc(N2C3CC4CC2CC(C3)N4C(=O)OC(C)(C)C)c1C |TLB:21:20:17:15.14.13,13:14:22:19.18.17,13:18:22:15.21.14,12:13:22.20.19:17,THB:21:14:22.20.19:17,23:22:17:15.14.13|
Show InChI InChI=1S/C24H31N5O3/c1-14-21(26-13-27-22(14)31-20-7-6-8-25-15(20)2)28-16-9-18-11-17(28)12-19(10-16)29(18)23(30)32-24(3,4)5/h6-8,13,16-19H,9-12H2,1-5H3
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486n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424553
PNG
(CHEMBL2312527)
Show SMILES CC[C@H](C)OC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2cccnc2C)c1C |r,TLB:11:10:7.12.13:15,5:7:15:9.10.16,THB:11:12:15:9.10.16,16:10:7:13.14.15,16:14:7:9.11.10,17:16:7.12.13:15|
Show InChI InChI=1S/C24H31N5O3/c1-5-14(2)31-24(30)29-19-9-17-10-20(29)12-18(11-19)28(17)22-15(3)23(27-13-26-22)32-21-7-6-8-25-16(21)4/h6-8,13-14,17-20H,5,9-12H2,1-4H3/t14-,17?,18?,19?,20?/m0/s1
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493n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424571
PNG
(CHEMBL2312501)
Show SMILES Cc1ncn(n1)-c1ccc(Oc2ncnc(N3C4CC5CC3CC(C4)N5C(=O)OC(C)(C)C)c2C)c(F)c1 |TLB:24:23:20:18.17.16,16:17:25:22.21.20,16:21:25:18.24.17,15:16:25.23.22:20,THB:24:17:25.23.22:20,26:25:20:18.17.16|
Show InChI InChI=1S/C27H32FN7O3/c1-15-24(34-18-8-20-10-19(34)11-21(9-18)35(20)26(36)38-27(3,4)5)29-13-30-25(15)37-23-7-6-17(12-22(23)28)33-14-31-16(2)32-33/h6-7,12-14,18-21H,8-11H2,1-5H3
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507n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424556
PNG
(CHEMBL2312522)
Show SMILES Cc1ncccc1Oc1ncnc(N2C3CC4CC2CC(C3)N4C(=O)OC2(C)CC2)c1C |TLB:21:20:17:15.14.13,13:14:22:19.18.17,13:18:22:15.21.14,12:13:22.20.19:17,THB:21:14:22.20.19:17,23:22:17:15.14.13|
Show InChI InChI=1S/C24H29N5O3/c1-14-21(26-13-27-22(14)31-20-5-4-8-25-15(20)2)28-16-9-18-11-17(28)12-19(10-16)29(18)23(30)32-24(3)6-7-24/h4-5,8,13,16-19H,6-7,9-12H2,1-3H3
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586n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424557
PNG
(CHEMBL2312523)
Show SMILES Cc1ncccc1Oc1ncnc(N2C3CC4CC2CC(C3)N4C(=O)OC2CCC2)c1C |TLB:21:20:17:15.14.13,13:14:22:19.18.17,13:18:22:15.21.14,12:13:22.20.19:17,THB:21:14:22.20.19:17,23:22:17:15.14.13|
Show InChI InChI=1S/C24H29N5O3/c1-14-22(26-13-27-23(14)32-21-7-4-8-25-15(21)2)28-16-9-18-11-17(28)12-19(10-16)29(18)24(30)31-20-5-3-6-20/h4,7-8,13,16-20H,3,5-6,9-12H2,1-2H3
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682n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424566
PNG
(CHEMBL2312508)
Show SMILES Cc1ncccc1Oc1ncnc(N2C3CC4CC2CC(C3)N4C(=O)OC(C)(C)C)c1F |TLB:21:20:17:15.14.13,13:14:22:19.18.17,13:18:22:15.21.14,12:13:22.20.19:17,THB:21:14:22.20.19:17,23:22:17:15.14.13|
Show InChI InChI=1S/C23H28FN5O3/c1-13-18(6-5-7-25-13)31-21-19(24)20(26-12-27-21)28-14-8-16-10-15(28)11-17(9-14)29(16)22(30)32-23(2,3)4/h5-7,12,14-17H,8-11H2,1-4H3
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814n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424570
PNG
(CHEMBL2312512)
Show SMILES CC(C)OC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2ccc(cc2F)C#N)c1C |TLB:10:9:6.11.12:14,4:6:14:8.9.15,THB:10:11:14:8.9.15,15:9:6:12.13.14,15:13:6:8.10.9,16:15:6.11.12:14|
Show InChI InChI=1S/C24H26FN5O3/c1-13(2)32-24(31)30-18-7-16-8-19(30)10-17(9-18)29(16)22-14(3)23(28-12-27-22)33-21-5-4-15(11-26)6-20(21)25/h4-6,12-13,16-19H,7-10H2,1-3H3
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912n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424572
PNG
(CHEMBL2312162)
Show SMILES Cc1ncn(n1)-c1ccc(Oc2ncnc(N3C4CC5CC3CC(C4)N5C(=O)OC(C)(C)C)c2C)cc1 |TLB:24:23:20:18.17.16,16:17:25:22.21.20,16:21:25:18.24.17,15:16:25.23.22:20,THB:24:17:25.23.22:20,26:25:20:18.17.16|
Show InChI InChI=1S/C27H33N7O3/c1-16-24(28-14-29-25(16)36-23-8-6-18(7-9-23)32-15-30-17(2)31-32)33-19-10-21-12-20(33)13-22(11-19)34(21)26(35)37-27(3,4)5/h6-9,14-15,19-22H,10-13H2,1-5H3
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948n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424574
PNG
(CHEMBL2312160)
Show SMILES CC(C)OC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2ccc(cc2F)C(=O)N(C)C)c1C |TLB:10:9:6.11.12:14,4:6:14:8.9.15,THB:10:11:14:8.9.15,15:9:6:12.13.14,15:13:6:8.10.9,16:15:6.11.12:14|
Show InChI InChI=1S/C26H32FN5O4/c1-14(2)35-26(34)32-19-9-17-10-20(32)12-18(11-19)31(17)23-15(3)24(29-13-28-23)36-22-7-6-16(8-21(22)27)25(33)30(4)5/h6-8,13-14,17-20H,9-12H2,1-5H3
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1.15E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50341312
PNG
((1R,5R,8R)-Isopropyl 8-(5-Methyl-6-(2-methylpyridi...)
Show SMILES CC(C)OC(=O)N1C[C@@H]2CO[C@H](C1)[C@@H]2Oc1ncnc(Oc2cccnc2C)c1C |r|
Show InChI InChI=1S/C21H26N4O5/c1-12(2)28-21(26)25-8-15-10-27-17(9-25)18(15)30-20-13(3)19(23-11-24-20)29-16-6-5-7-22-14(16)4/h5-7,11-12,15,17-18H,8-10H2,1-4H3/t15-,17-,18-/m1/s1
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1.18E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl...


J Med Chem 54: 1948-52 (2011)


Article DOI: 10.1021/jm200003p
BindingDB Entry DOI: 10.7270/Q2CZ37G0
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424567
PNG
(CHEMBL2312509)
Show SMILES COc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)C |TLB:24:23:20:18.17.16,16:17:25:22.21.20,16:21:25:18.24.17,15:16:25.23.22:20,THB:24:17:25.23.22:20,26:25:20:18.17.16|
Show InChI InChI=1S/C23H29N5O4/c1-13(2)31-23(29)28-17-8-15-9-18(28)11-16(10-17)27(15)21-20(30-4)22(26-12-25-21)32-19-6-5-7-24-14(19)3/h5-7,12-13,15-18H,8-11H2,1-4H3
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1.50E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50341311
PNG
((+/-)-isopropyl 8-(5-methyl-6-(2-methylpyridin-3-y...)
Show SMILES CC(C)OC(=O)N1CC2COC(C1)C2Oc1ncnc(Oc2cccnc2C)c1C
Show InChI InChI=1S/C21H26N4O5/c1-12(2)28-21(26)25-8-15-10-27-17(9-25)18(15)30-20-13(3)19(23-11-24-20)29-16-6-5-7-22-14(16)4/h5-7,11-12,15,17-18H,8-10H2,1-4H3
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1.60E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl...


J Med Chem 54: 1948-52 (2011)


Article DOI: 10.1021/jm200003p
BindingDB Entry DOI: 10.7270/Q2CZ37G0
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424554
PNG
(CHEMBL2312521)
Show SMILES CCOC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2cccnc2C)c1C |TLB:9:8:5.10.11:13,3:5:13:7.8.14,THB:9:10:13:7.8.14,14:8:5:11.12.13,14:12:5:7.9.8,15:14:5.10.11:13|
Show InChI InChI=1S/C22H27N5O3/c1-4-29-22(28)27-17-8-15-9-18(27)11-16(10-17)26(15)20-13(2)21(25-12-24-20)30-19-6-5-7-23-14(19)3/h5-7,12,15-18H,4,8-11H2,1-3H3
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1.97E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424551
PNG
(CHEMBL2312520)
Show SMILES CC(C)OC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2cccnc2C)c1C |TLB:10:9:6.11.12:14,4:6:14:8.9.15,THB:10:11:14:8.9.15,15:9:6:12.13.14,15:13:6:8.10.9,16:15:6.11.12:14|
Show InChI InChI=1S/C23H29N5O3/c1-13(2)30-23(29)28-18-8-16-9-19(28)11-17(10-18)27(16)21-14(3)22(26-12-25-21)31-20-6-5-7-24-15(20)4/h5-7,12-13,16-19H,8-11H2,1-4H3
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2.23E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50341313
PNG
((1S,5S,8S)-Isopropyl 8-(5-Methyl-6-(2-methylpyridi...)
Show SMILES CC(C)OC(=O)N1C[C@H]2CO[C@@H](C1)[C@H]2Oc1ncnc(Oc2cccnc2C)c1C |r|
Show InChI InChI=1S/C21H26N4O5/c1-12(2)28-21(26)25-8-15-10-27-17(9-25)18(15)30-20-13(3)19(23-11-24-20)29-16-6-5-7-22-14(16)4/h5-7,11-12,15,17-18H,8-10H2,1-4H3/t15-,17-,18-/m0/s1
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2.27E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl...


J Med Chem 54: 1948-52 (2011)


Article DOI: 10.1021/jm200003p
BindingDB Entry DOI: 10.7270/Q2CZ37G0
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424568
PNG
(CHEMBL2312510)
Show SMILES COc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1 |TLB:24:23:20:18.17.16,16:17:25:22.21.20,16:21:25:18.24.17,15:16:25.23.22:20,THB:24:17:25.23.22:20,26:25:20:18.17.16|
Show InChI InChI=1S/C24H29N5O4/c1-14-19(5-4-8-25-14)32-22-20(31-3)21(26-13-27-22)28-15-9-17-11-16(28)12-18(10-15)29(17)23(30)33-24(2)6-7-24/h4-5,8,13,15-18H,6-7,9-12H2,1-3H3
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3.12E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424565
PNG
(CHEMBL2312507)
Show SMILES Cc1ncccc1Oc1ncnc(N2C3CC4CC2CC(C3)N4C(=O)OC2(C)CC2)c1F |TLB:21:20:17:15.14.13,13:14:22:19.18.17,13:18:22:15.21.14,12:13:22.20.19:17,THB:21:14:22.20.19:17,23:22:17:15.14.13|
Show InChI InChI=1S/C23H26FN5O3/c1-13-18(4-3-7-25-13)31-21-19(24)20(26-12-27-21)28-14-8-16-10-15(28)11-17(9-14)29(16)22(30)32-23(2)5-6-23/h3-4,7,12,14-17H,5-6,8-11H2,1-2H3
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>7.32E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424561
PNG
(CHEMBL2312503)
Show SMILES Cc1ncccc1Oc1cc(ncn1)N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C |TLB:22:21:18:16.15.14,14:15:23:20.19.18,14:19:23:16.22.15,10:14:23.21.20:18,THB:22:15:23.21.20:18,24:23:18:16.15.14|
Show InChI InChI=1S/C23H29N5O3/c1-14-19(6-5-7-24-14)30-21-12-20(25-13-26-21)27-15-8-17-10-16(27)11-18(9-15)28(17)22(29)31-23(2,3)4/h5-7,12-13,15-18H,8-11H2,1-4H3
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>8.15E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424560
PNG
(CHEMBL2312502)
Show SMILES Cc1ncccc1Oc1cc(ncn1)N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1 |TLB:22:21:18:16.15.14,14:15:23:20.19.18,14:19:23:16.22.15,10:14:23.21.20:18,THB:22:15:23.21.20:18,24:23:18:16.15.14|
Show InChI InChI=1S/C23H27N5O3/c1-14-19(4-3-7-24-14)30-21-12-20(25-13-26-21)27-15-8-17-10-16(27)11-18(9-15)28(17)22(29)31-23(2)5-6-23/h3-4,7,12-13,15-18H,5-6,8-11H2,1-2H3
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>8.15E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50193995
PNG
(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r|
Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISA


J Med Chem 53: 8468-84 (2010)


Article DOI: 10.1021/jm1004286
BindingDB Entry DOI: 10.7270/Q2154H9D
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50137174
PNG
((1H-Indol-5-yl)-(6-thiophen-2-yl-thieno[3,2-d]pyri...)
Show SMILES N(c1ccc2[nH]ccc2c1)c1ncnc2cc(sc12)-c1cccs1
Show InChI InChI=1S/C18H12N4S2/c1-2-15(23-7-1)16-9-14-17(24-16)18(21-10-20-14)22-12-3-4-13-11(8-12)5-6-19-13/h1-10,19H,(H,20,21,22)
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n/an/a 1n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor


Bioorg Med Chem Lett 14: 21-4 (2003)


BindingDB Entry DOI: 10.7270/Q2FT8KFT
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50137173
PNG
(CHEMBL312818 | N*6*-Imidazol-1-yl-N*4*-(1H-indol-5...)
Show SMILES C(CN(c1cc2ncnc(Nc3ccc4[nH]ccc4c3)c2s1)n1ccnc1)Cc1ccccc1
Show InChI InChI=1S/C26H23N7S/c1-2-5-19(6-3-1)7-4-13-33(32-14-12-27-18-32)24-16-23-25(34-24)26(30-17-29-23)31-21-8-9-22-20(15-21)10-11-28-22/h1-3,5-6,8-12,14-18,28H,4,7,13H2,(H,29,30,31)
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n/an/a 1n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor


Bioorg Med Chem Lett 14: 21-4 (2003)


BindingDB Entry DOI: 10.7270/Q2FT8KFT
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50137175
PNG
(2-{4-[4-(1H-Indol-5-ylamino)-thieno[3,2-d]pyrimidi...)
Show SMILES CC(C)(CO)NCc1ccc(cc1)-c1cc2ncnc(Nc3ccc4[nH]ccc4c3)c2s1
Show InChI InChI=1S/C25H25N5OS/c1-25(2,14-31)29-13-16-3-5-17(6-4-16)22-12-21-23(32-22)24(28-15-27-21)30-19-7-8-20-18(11-19)9-10-26-20/h3-12,15,26,29,31H,13-14H2,1-2H3,(H,27,28,30)
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n/an/a 1n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against epidermal growth factor receptor


Bioorg Med Chem Lett 14: 21-4 (2003)


BindingDB Entry DOI: 10.7270/Q2FT8KFT
More data for this
Ligand-Target Pair
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