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Compile Data Set for Download or QSAR

Found 118 hits with Last Name = 'newcomb' and Initial = 'jr'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM14949
PNG
(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)
Show SMILES Cc1ccc(cc1-c1ccc2nc(N)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O/c1-13-5-6-15(21(31)29-18-4-2-3-17(11-18)23(24,25)26)10-19(13)14-7-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30)
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n/an/a 0.200n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50372706
PNG
(CHEMBL257858)
Show SMILES COc1nc(Nc2ccc(cc2)N2CCN(C)CC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C32H31F4N7O3/c1-19-7-8-20(28(44)39-25-6-4-5-24(27(25)33)32(34,35)36)17-26(19)40-29(45)23-18-37-31(41-30(23)46-3)38-21-9-11-22(12-10-21)43-15-13-42(2)14-16-43/h4-12,17-18H,13-16H2,1-3H3,(H,39,44)(H,40,45)(H,37,38,41)
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n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM14949
PNG
(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)
Show SMILES Cc1ccc(cc1-c1ccc2nc(N)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O/c1-13-5-6-15(21(31)29-18-4-2-3-17(11-18)23(24,25)26)10-19(13)14-7-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30)
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n/an/a 2n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM14949
PNG
(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)
Show SMILES Cc1ccc(cc1-c1ccc2nc(N)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O/c1-13-5-6-15(21(31)29-18-4-2-3-17(11-18)23(24,25)26)10-19(13)14-7-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30)
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n/an/a 2n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340122
PNG
(CHEMBL1760036 | N4-(naphthalen-2-yl)-N2-(3,4,5-tri...)
Show SMILES COc1cc(Nc2nccc(Nc3ccc4ccccc4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C23H22N4O3/c1-28-19-13-18(14-20(29-2)22(19)30-3)26-23-24-11-10-21(27-23)25-17-9-8-15-6-4-5-7-16(15)12-17/h4-14H,1-3H3,(H2,24,25,26,27)
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n/an/a 2.20n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340126
PNG
(CHEMBL1738698 | N2-(3-methoxy-4-morpholinophenyl)-...)
Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)ccc1N1CCOCC1
Show InChI InChI=1S/C24H24N6O2/c1-31-22-15-18(6-7-21(22)30-10-12-32-13-11-30)28-24-25-9-8-23(29-24)27-19-14-17-4-2-3-5-20(17)26-16-19/h2-9,14-16H,10-13H2,1H3,(H2,25,27,28,29)
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n/an/a 2.40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50372708
PNG
(CHEMBL269936)
Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2F)C(F)(F)F)c(NC)n1
Show InChI InChI=1S/C22H20F4N6O2/c1-11-7-8-12(19(33)30-15-6-4-5-14(17(15)23)22(24,25)26)9-16(11)31-20(34)13-10-29-21(28-3)32-18(13)27-2/h4-10H,1-3H3,(H,30,33)(H,31,34)(H2,27,28,29,32)
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n/an/a 2.40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of p38alpha


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340121
PNG
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27)
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n/an/a 2.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50340121
PNG
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27)
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n/an/a 3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of INSR


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340128
PNG
(CHEMBL1760041 | N4-(quinolin-6-yl)-N2-(3,4,5-trime...)
Show SMILES COc1cc(Nc2nccc(Nc3ccc4ncccc4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H21N5O3/c1-28-18-12-16(13-19(29-2)21(18)30-3)26-22-24-10-8-20(27-22)25-15-6-7-17-14(11-15)5-4-9-23-17/h4-13H,1-3H3,(H2,24,25,26,27)
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n/an/a 3.30n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340144
PNG
(CHEMBL1760058 | N2-(3-methoxy-4-(3-(piperidin-1-yl...)
Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)ccc1OCCCN1CCCCC1
Show InChI InChI=1S/C28H32N6O2/c1-35-26-19-22(10-11-25(26)36-17-7-16-34-14-5-2-6-15-34)32-28-29-13-12-27(33-28)31-23-18-21-8-3-4-9-24(21)30-20-23/h3-4,8-13,18-20H,2,5-7,14-17H2,1H3,(H2,29,31,32,33)
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n/an/a 3.80n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340127
PNG
(CHEMBL1760040 | N4-(isoquinolin-3-yl)-N2-(3,4,5-tr...)
Show SMILES COc1cc(Nc2nccc(Nc3cc4ccccc4cn3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H21N5O3/c1-28-17-11-16(12-18(29-2)21(17)30-3)25-22-23-9-8-19(27-22)26-20-10-14-6-4-5-7-15(14)13-24-20/h4-13H,1-3H3,(H2,23,24,25,26,27)
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n/an/a 5.20n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM14949
PNG
(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)
Show SMILES Cc1ccc(cc1-c1ccc2nc(N)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O/c1-13-5-6-15(21(31)29-18-4-2-3-17(11-18)23(24,25)26)10-19(13)14-7-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30)
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n/an/a 6n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of p38alpha


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50372710
PNG
(CHEMBL255533)
Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2F)C(F)(F)F)c(OC)n1
Show InChI InChI=1S/C22H19F4N5O3/c1-11-7-8-12(18(32)29-15-6-4-5-14(17(15)23)22(24,25)26)9-16(11)30-19(33)13-10-28-21(27-2)31-20(13)34-3/h4-10H,1-3H3,(H,29,32)(H,30,33)(H,27,28,31)
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n/an/a 7n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340126
PNG
(CHEMBL1738698 | N2-(3-methoxy-4-morpholinophenyl)-...)
Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)ccc1N1CCOCC1
Show InChI InChI=1S/C24H24N6O2/c1-31-22-15-18(6-7-21(22)30-10-12-32-13-11-30)28-24-25-9-8-23(29-24)27-19-14-17-4-2-3-5-20(17)26-16-19/h2-9,14-16H,10-13H2,1H3,(H2,25,27,28,29)
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n/an/a 8.40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340120
PNG
(CHEMBL1760034 | N2-(naphthalen-2-yl)-N4-(3,4,5-tri...)
Show SMILES COc1cc(Nc2ncnc(Nc3ccc4ccccc4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-17(12-19(29-2)20(18)30-3)26-22-24-13-23-21(27-22)25-16-9-8-14-6-4-5-7-15(14)10-16/h4-13H,1-3H3,(H2,23,24,25,26,27)
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n/an/a 13n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340127
PNG
(CHEMBL1760040 | N4-(isoquinolin-3-yl)-N2-(3,4,5-tr...)
Show SMILES COc1cc(Nc2nccc(Nc3cc4ccccc4cn3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H21N5O3/c1-28-17-11-16(12-18(29-2)21(17)30-3)25-22-23-9-8-19(27-22)26-20-10-14-6-4-5-7-15(14)13-24-20/h4-13H,1-3H3,(H2,23,24,25,26,27)
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n/an/a 14n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340135
PNG
(CHEMBL1760049 | N2-(3,4-dimethoxyphenyl)-N4-(quino...)
Show SMILES COc1ccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc1OC
Show InChI InChI=1S/C21H19N5O2/c1-27-18-8-7-15(12-19(18)28-2)25-21-22-10-9-20(26-21)24-16-11-14-5-3-4-6-17(14)23-13-16/h3-13H,1-2H3,(H2,22,24,25,26)
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n/an/a 18n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340143
PNG
(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)
Show SMILES C(COc1ccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc1)CN1CCCCC1
Show InChI InChI=1S/C27H30N6O/c1-4-15-33(16-5-1)17-6-18-34-24-11-9-22(10-12-24)31-27-28-14-13-26(32-27)30-23-19-21-7-2-3-8-25(21)29-20-23/h2-3,7-14,19-20H,1,4-6,15-18H2,(H2,28,30,31,32)
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n/an/a 19n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50372714
PNG
(CHEMBL255989)
Show SMILES COc1nc(NCCCN2CCN(C)CC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C30H36F3N7O3/c1-19-9-10-21(26(41)36-24-8-5-7-23(20(24)2)30(31,32)33)17-25(19)37-27(42)22-18-35-29(38-28(22)43-4)34-11-6-12-40-15-13-39(3)14-16-40/h5,7-10,17-18H,6,11-16H2,1-4H3,(H,36,41)(H,37,42)(H,34,35,38)
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n/an/a 19n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340121
PNG
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27)
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n/an/a 19n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340136
PNG
(CHEMBL1760050 | N2-(3,5-dimethoxyphenyl)-N4-(quino...)
Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1
Show InChI InChI=1S/C21H19N5O2/c1-27-17-10-15(11-18(12-17)28-2)25-21-22-8-7-20(26-21)24-16-9-14-5-3-4-6-19(14)23-13-16/h3-13H,1-2H3,(H2,22,24,25,26)
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n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM14949
PNG
(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)
Show SMILES Cc1ccc(cc1-c1ccc2nc(N)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O/c1-13-5-6-15(21(31)29-18-4-2-3-17(11-18)23(24,25)26)10-19(13)14-7-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30)
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n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Jak3


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50372711
PNG
(CHEMBL270793)
Show SMILES COc1nc(NCCN2CCOCC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H29F3N6O4/c1-17-6-7-18(23(37)33-20-5-3-4-19(15-20)27(28,29)30)14-22(17)34-24(38)21-16-32-26(35-25(21)39-2)31-8-9-36-10-12-40-13-11-36/h3-7,14-16H,8-13H2,1-2H3,(H,33,37)(H,34,38)(H,31,32,35)
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n/an/a 22n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340142
PNG
(CHEMBL1760056 | N2-(4-morpholinophenyl)-N4-(quinol...)
Show SMILES C1CN(CCO1)c1ccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc1
Show InChI InChI=1S/C23H22N6O/c1-2-4-21-17(3-1)15-19(16-25-21)26-22-9-10-24-23(28-22)27-18-5-7-20(8-6-18)29-11-13-30-14-12-29/h1-10,15-16H,11-14H2,(H2,24,26,27,28)
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n/an/a 22n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50340143
PNG
(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)
Show SMILES C(COc1ccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc1)CN1CCCCC1
Show InChI InChI=1S/C27H30N6O/c1-4-15-33(16-5-1)17-6-18-34-24-11-9-22(10-12-24)31-27-28-14-13-26(32-27)30-23-19-21-7-2-3-8-25(21)29-20-23/h2-3,7-14,19-20H,1,4-6,15-18H2,(H2,28,30,31,32)
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n/an/a 24n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of INSR


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50372712
PNG
(CHEMBL271099)
Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2)C(F)(F)F)c(Oc2ccccc2)n1
Show InChI InChI=1S/C27H22F3N5O3/c1-16-11-12-17(23(36)33-19-8-6-7-18(14-19)27(28,29)30)13-22(16)34-24(37)21-15-32-26(31-2)35-25(21)38-20-9-4-3-5-10-20/h3-15H,1-2H3,(H,33,36)(H,34,37)(H,31,32,35)
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n/an/a 25n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340118
PNG
(CHEMBL1760048 | N4-(3-(trifluoromethoxy)phenyl)-N2...)
Show SMILES COc1cc(Nc2nccc(Nc3cccc(OC(F)(F)F)c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C20H19F3N4O4/c1-28-15-10-13(11-16(29-2)18(15)30-3)26-19-24-8-7-17(27-19)25-12-5-4-6-14(9-12)31-20(21,22)23/h4-11H,1-3H3,(H2,24,25,26,27)
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n/an/a 30n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340131
PNG
(CHEMBL1760044 | N4-(1H-indazol-5-yl)-N2-(3,4,5-tri...)
Show SMILES COc1cc(Nc2nccc(Nc3ccc4[nH]ncc4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C20H20N6O3/c1-27-16-9-14(10-17(28-2)19(16)29-3)24-20-21-7-6-18(25-20)23-13-4-5-15-12(8-13)11-22-26-15/h4-11H,1-3H3,(H,22,26)(H2,21,23,24,25)
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n/an/a 34n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340144
PNG
(CHEMBL1760058 | N2-(3-methoxy-4-(3-(piperidin-1-yl...)
Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)ccc1OCCCN1CCCCC1
Show InChI InChI=1S/C28H32N6O2/c1-35-26-19-22(10-11-25(26)36-17-7-16-34-14-5-2-6-15-34)32-28-29-13-12-27(33-28)31-23-18-21-8-3-4-9-24(21)30-20-23/h3-4,8-13,18-20H,2,5-7,14-17H2,1H3,(H2,29,31,32,33)
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n/an/a 36n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340141
PNG
(CHEMBL1760055 | N2-(3-chloro-4-methoxyphenyl)-N4-(...)
Show SMILES COc1ccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc1Cl
Show InChI InChI=1S/C20H16ClN5O/c1-27-18-7-6-14(11-16(18)21)25-20-22-9-8-19(26-20)24-15-10-13-4-2-3-5-17(13)23-12-15/h2-12H,1H3,(H2,22,24,25,26)
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n/an/a 36n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340128
PNG
(CHEMBL1760041 | N4-(quinolin-6-yl)-N2-(3,4,5-trime...)
Show SMILES COc1cc(Nc2nccc(Nc3ccc4ncccc4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H21N5O3/c1-28-18-12-16(13-19(29-2)21(18)30-3)26-22-24-10-8-20(27-22)25-15-6-7-17-14(11-15)5-4-9-23-17/h4-13H,1-3H3,(H2,24,25,26,27)
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n/an/a 37n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340138
PNG
(CHEMBL1760052 | N2-(3-methoxyphenyl)-N4-(quinolin-...)
Show SMILES COc1cccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)c1
Show InChI InChI=1S/C20H17N5O/c1-26-17-7-4-6-15(12-17)24-20-21-10-9-19(25-20)23-16-11-14-5-2-3-8-18(14)22-13-16/h2-13H,1H3,(H2,21,23,24,25)
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n/an/a 40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340119
PNG
(CHEMBL1760033 | N2-(quinolin-3-yl)-N4-(3,4,5-trime...)
Show SMILES COc1cc(Nc2ncnc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C21H20N6O3/c1-28-17-9-14(10-18(29-2)19(17)30-3)25-20-23-12-24-21(27-20)26-15-8-13-6-4-5-7-16(13)22-11-15/h4-12H,1-3H3,(H2,23,24,25,26,27)
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n/an/a 41n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340140
PNG
(CHEMBL1760054 | N2-(3-chlorophenyl)-N4-(quinolin-3...)
Show SMILES Clc1cccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)c1
Show InChI InChI=1S/C19H14ClN5/c20-14-5-3-6-15(11-14)24-19-21-9-8-18(25-19)23-16-10-13-4-1-2-7-17(13)22-12-16/h1-12H,(H2,21,23,24,25)
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n/an/a 41n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50372707
PNG
(CHEMBL408292)
Show SMILES Cc1ccc(cc1NC(=O)c1cnc(NCCN2CCOCC2)nc1Oc1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C32H31F3N6O4/c1-21-10-11-22(28(42)38-24-7-5-6-23(19-24)32(33,34)35)18-27(21)39-29(43)26-20-37-31(36-12-13-41-14-16-44-17-15-41)40-30(26)45-25-8-3-2-4-9-25/h2-11,18-20H,12-17H2,1H3,(H,38,42)(H,39,43)(H,36,37,40)
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n/an/a 41n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50372715
PNG
(CHEMBL271101)
Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2C)C(F)(F)F)c(OC)n1
Show InChI InChI=1S/C23H22F3N5O3/c1-12-8-9-14(19(32)29-17-7-5-6-16(13(17)2)23(24,25)26)10-18(12)30-20(33)15-11-28-22(27-3)31-21(15)34-4/h5-11H,1-4H3,(H,29,32)(H,30,33)(H,27,28,31)
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n/an/a 44n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50372713
PNG
(CHEMBL255132)
Show SMILES COc1nc(NCCCCN(C)C)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C28H33F3N6O3/c1-17-11-12-19(24(38)34-22-10-8-9-21(18(22)2)28(29,30)31)15-23(17)35-25(39)20-16-33-27(36-26(20)40-5)32-13-6-7-14-37(3)4/h8-12,15-16H,6-7,13-14H2,1-5H3,(H,34,38)(H,35,39)(H,32,33,36)
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n/an/a 45n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340123
PNG
(CHEMBL1760037 | N4-(2-methylquinolin-3-yl)-N2-(3,4...)
Show SMILES COc1cc(Nc2nccc(Nc3cc4ccccc4nc3C)n2)cc(OC)c1OC
Show InChI InChI=1S/C23H23N5O3/c1-14-18(11-15-7-5-6-8-17(15)25-14)27-21-9-10-24-23(28-21)26-16-12-19(29-2)22(31-4)20(13-16)30-3/h5-13H,1-4H3,(H2,24,26,27,28)
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n/an/a 48n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50372716
PNG
(CHEMBL271018)
Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2)C(F)(F)F)c(OC)n1
Show InChI InChI=1S/C22H20F3N5O3/c1-12-7-8-13(18(31)28-15-6-4-5-14(10-15)22(23,24)25)9-17(12)29-19(32)16-11-27-21(26-2)30-20(16)33-3/h4-11H,1-3H3,(H,28,31)(H,29,32)(H,26,27,30)
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n/an/a 53n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340137
PNG
(CHEMBL1760051 | N2-(4-methoxyphenyl)-N4-(quinolin-...)
Show SMILES COc1ccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc1
Show InChI InChI=1S/C20H17N5O/c1-26-17-8-6-15(7-9-17)24-20-21-11-10-19(25-20)23-16-12-14-4-2-3-5-18(14)22-13-16/h2-13H,1H3,(H2,21,23,24,25)
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n/an/a 55n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340129
PNG
(CHEMBL1760042 | N4-(quinoxalin-6-yl)-N2-(3,4,5-tri...)
Show SMILES COc1cc(Nc2nccc(Nc3ccc4nccnc4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C21H20N6O3/c1-28-17-11-14(12-18(29-2)20(17)30-3)26-21-24-7-6-19(27-21)25-13-4-5-15-16(10-13)23-9-8-22-15/h4-12H,1-3H3,(H2,24,25,26,27)
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n/an/a 58n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340143
PNG
(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)
Show SMILES C(COc1ccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc1)CN1CCCCC1
Show InChI InChI=1S/C27H30N6O/c1-4-15-33(16-5-1)17-6-18-34-24-11-9-22(10-12-24)31-27-28-14-13-26(32-27)30-23-19-21-7-2-3-8-25(21)29-20-23/h2-3,7-14,19-20H,1,4-6,15-18H2,(H2,28,30,31,32)
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n/an/a 81n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50372708
PNG
(CHEMBL269936)
Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2F)C(F)(F)F)c(NC)n1
Show InChI InChI=1S/C22H20F4N6O2/c1-11-7-8-12(19(33)30-15-6-4-5-14(17(15)23)22(24,25)26)9-16(11)31-20(34)13-10-29-21(28-3)32-18(13)27-2/h4-10H,1-3H3,(H,30,33)(H,31,34)(H2,27,28,29,32)
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n/an/a 84n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340122
PNG
(CHEMBL1760036 | N4-(naphthalen-2-yl)-N2-(3,4,5-tri...)
Show SMILES COc1cc(Nc2nccc(Nc3ccc4ccccc4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C23H22N4O3/c1-28-19-13-18(14-20(29-2)22(19)30-3)26-23-24-11-10-21(27-23)25-17-9-8-15-6-4-5-7-16(15)12-17/h4-14H,1-3H3,(H2,24,25,26,27)
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n/an/a 88n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50340121
PNG
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27)
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n/an/a 94n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50372709
PNG
(CHEMBL271650)
Show SMILES COc1nc(NC2CCN(C)CC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H29F3N6O3/c1-16-7-8-17(23(37)32-20-6-4-5-18(14-20)27(28,29)30)13-22(16)34-24(38)21-15-31-26(35-25(21)39-3)33-19-9-11-36(2)12-10-19/h4-8,13-15,19H,9-12H2,1-3H3,(H,32,37)(H,34,38)(H,31,33,35)
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n/an/a 101n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF assay


Bioorg Med Chem Lett 18: 1172-6 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.123
BindingDB Entry DOI: 10.7270/Q2WD41FK
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340130
PNG
(CHEMBL1760043 | N4-(1H-indazol-6-yl)-N2-(3,4,5-tri...)
Show SMILES COc1cc(Nc2nccc(Nc3ccc4cn[nH]c4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C20H20N6O3/c1-27-16-9-14(10-17(28-2)19(16)29-3)24-20-21-7-6-18(25-20)23-13-5-4-12-11-22-26-15(12)8-13/h4-11H,1-3H3,(H,22,26)(H2,21,23,24,25)
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n/an/a 103n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340133
PNG
(CHEMBL1760046 | N4-(3,3-dimethylindolin-6-yl)-N2-(...)
Show SMILES COc1cc(Nc2nccc(Nc3ccc4c(NCC4(C)C)c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C23H27N5O3/c1-23(2)13-25-17-10-14(6-7-16(17)23)26-20-8-9-24-22(28-20)27-15-11-18(29-3)21(31-5)19(12-15)30-4/h6-12,25H,13H2,1-5H3,(H2,24,26,27,28)
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n/an/a 123n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340119
PNG
(CHEMBL1760033 | N2-(quinolin-3-yl)-N4-(3,4,5-trime...)
Show SMILES COc1cc(Nc2ncnc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C21H20N6O3/c1-28-17-9-14(10-18(29-2)19(17)30-3)25-20-23-12-24-21(27-20)26-15-8-13-6-4-5-7-16(13)22-11-15/h4-12H,1-3H3,(H2,23,24,25,26,27)
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n/an/a 175n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
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