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Compile Data Set for Download or QSAR

Found 139 hits with Last Name = 'nishikawa' and Initial = 'y'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185979
PNG
(1-acetyl-N-{3-[4-(4-carbamoylbenzyl)piperidin-1-yl...)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccc(cc2)C(N)=O)CC1)c1ccc(C)c(Cl)c1
Show InChI InChI=1S/C31H41ClN4O3/c1-22-4-9-28(21-29(22)32)36(31(39)27-12-18-35(19-13-27)23(2)37)15-3-14-34-16-10-25(11-17-34)20-24-5-7-26(8-6-24)30(33)38/h4-9,21,25,27H,3,10-20H2,1-2H3,(H2,33,38)
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n/an/a 0.420n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185967
PNG
(CHEMBL207487 | N-(3-(4-(4-(methylsulfonyl)benzyl)p...)
Show SMILES CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccc(cc2)S(C)(=O)=O)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H39Cl2N3O5S2/c1-40(36,37)26-7-4-22(5-8-26)20-23-10-16-32(17-11-23)14-3-15-34(25-6-9-27(30)28(31)21-25)29(35)24-12-18-33(19-13-24)41(2,38)39/h4-9,21,23-24H,3,10-20H2,1-2H3
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n/an/a 0.800n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185972
PNG
(CHEMBL207182 | N-(3-(4-(4-fluorobenzyl)piperidin-1...)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H36Cl2FN3O2/c1-21(36)34-17-11-24(12-18-34)29(37)35(26-7-8-27(30)28(31)20-26)14-2-13-33-15-9-23(10-16-33)19-22-3-5-25(32)6-4-22/h3-8,20,23-24H,2,9-19H2,1H3
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185973
PNG
(CHEMBL207630 | N-{3-[4-(4-cyanobenzyl)piperidin-1-...)
Show SMILES CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccc(cc2)C#N)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H36Cl2N4O3S/c1-39(37,38)34-17-11-25(12-18-34)29(36)35(26-7-8-27(30)28(31)20-26)14-2-13-33-15-9-23(10-16-33)19-22-3-5-24(21-32)6-4-22/h3-8,20,23,25H,2,9-19H2,1H3
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n/an/a 1.40n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50088301
PNG
((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Show SMILES Cc1ccc(cc1)-c1ccc2CCCC(=Cc2c1)C(=O)Nc1ccc(C[N+](C)(C)C2CCOCC2)cc1 |c:15|
Show InChI InChI=1S/C33H38N2O2/c1-24-7-11-27(12-8-24)28-14-13-26-5-4-6-29(22-30(26)21-28)33(36)34-31-15-9-25(10-16-31)23-35(2,3)32-17-19-37-20-18-32/h7-16,21-22,32H,4-6,17-20,23H2,1-3H3/p+1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES


J Med Chem 43: 2049-63 (2000)


BindingDB Entry DOI: 10.7270/Q26D5S75
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50088321
PNG
(CHEMBL292548 | Dimethyl-(tetrahydro-pyran-4-yl)-{4...)
Show SMILES Cc1ccc(cc1)-c1ccc2OCCC(=Cc2c1)C(=O)Nc1ccc(C[N+](C)(C)C2CCOCC2)cc1 |c:15|
Show InChI InChI=1S/C32H36N2O3/c1-23-4-8-25(9-5-23)26-10-13-31-28(20-26)21-27(14-19-37-31)32(35)33-29-11-6-24(7-12-29)22-34(2,3)30-15-17-36-18-16-30/h4-13,20-21,30H,14-19,22H2,1-3H3/p+1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES


J Med Chem 43: 2049-63 (2000)


BindingDB Entry DOI: 10.7270/Q26D5S75
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50088302
PNG
(CHEMBL56565 | Dimethyl-(tetrahydro-pyran-4-yl)-(4-...)
Show SMILES C[N+](C)(Cc1ccc(NC(=O)C2=Cc3cc(ccc3OCC2)-c2ccc(cc2)C(F)(F)F)cc1)C1CCOCC1 |t:11|
Show InChI InChI=1S/C32H33F3N2O3/c1-37(2,29-14-16-39-17-15-29)21-22-3-10-28(11-4-22)36-31(38)25-13-18-40-30-12-7-24(19-26(30)20-25)23-5-8-27(9-6-23)32(33,34)35/h3-12,19-20,29H,13-18,21H2,1-2H3/p+1
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n/an/a 1.5n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES


J Med Chem 43: 2049-63 (2000)


BindingDB Entry DOI: 10.7270/Q26D5S75
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185973
PNG
(CHEMBL207630 | N-{3-[4-(4-cyanobenzyl)piperidin-1-...)
Show SMILES CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccc(cc2)C#N)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H36Cl2N4O3S/c1-39(37,38)34-17-11-25(12-18-34)29(36)35(26-7-8-27(30)28(31)20-26)14-2-13-33-15-9-23(10-16-33)19-22-3-5-24(21-32)6-4-22/h3-8,20,23,25H,2,9-19H2,1H3
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185963
PNG
(1-acetyl-N-(3,4-dichlorophenyl)-N-(3-{4-[(4-fluoro...)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(CC1)Sc1ccc(F)cc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C28H34Cl2FN3O2S/c1-20(35)33-17-9-21(10-18-33)28(36)34(23-5-8-26(29)27(30)19-23)14-2-13-32-15-11-25(12-16-32)37-24-6-3-22(31)4-7-24/h3-8,19,21,25H,2,9-18H2,1H3
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50088301
PNG
((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Show SMILES Cc1ccc(cc1)-c1ccc2CCCC(=Cc2c1)C(=O)Nc1ccc(C[N+](C)(C)C2CCOCC2)cc1 |c:15|
Show InChI InChI=1S/C33H38N2O2/c1-24-7-11-27(12-8-24)28-14-13-26-5-4-6-29(22-30(26)21-28)33(36)34-31-15-9-25(10-16-31)23-35(2,3)32-17-19-37-20-18-32/h7-16,21-22,32H,4-6,17-20,23H2,1-3H3/p+1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES


J Med Chem 43: 2049-63 (2000)


BindingDB Entry DOI: 10.7270/Q26D5S75
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50088322
PNG
((4-{[7-(4-Ethoxy-phenyl)-2,3-dihydro-benzo[b]oxepi...)
Show SMILES CCOc1ccc(cc1)-c1ccc2OCCC(=Cc2c1)C(=O)Nc1ccc(C[N+](C)(C)C2CCOCC2)cc1 |c:17|
Show InChI InChI=1S/C33H38N2O4/c1-4-38-31-12-7-25(8-13-31)26-9-14-32-28(21-26)22-27(15-20-39-32)33(36)34-29-10-5-24(6-11-29)23-35(2,3)30-16-18-37-19-17-30/h5-14,21-22,30H,4,15-20,23H2,1-3H3/p+1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES


J Med Chem 43: 2049-63 (2000)


BindingDB Entry DOI: 10.7270/Q26D5S75
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185963
PNG
(1-acetyl-N-(3,4-dichlorophenyl)-N-(3-{4-[(4-fluoro...)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(CC1)Sc1ccc(F)cc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C28H34Cl2FN3O2S/c1-20(35)33-17-9-21(10-18-33)28(36)34(23-5-8-26(29)27(30)19-23)14-2-13-32-15-11-25(12-16-32)37-24-6-3-22(31)4-7-24/h3-8,19,21,25H,2,9-18H2,1H3
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185964
PNG
(CHEMBL382252 | N-{3-[4-(3-carbamoylbenzyl)piperidi...)
Show SMILES CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2cccc(c2)C(N)=O)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H38Cl2N4O4S/c1-40(38,39)34-16-10-23(11-17-34)29(37)35(25-6-7-26(30)27(31)20-25)13-3-12-33-14-8-21(9-15-33)18-22-4-2-5-24(19-22)28(32)36/h2,4-7,19-21,23H,3,8-18H2,1H3,(H2,32,36)
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n/an/a 2n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185961
PNG
(CHEMBL207190 | N-(3-(4-(4-fluorobenzyl)piperidin-1...)
Show SMILES CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C28H36Cl2FN3O3S/c1-38(36,37)33-17-11-23(12-18-33)28(35)34(25-7-8-26(29)27(30)20-25)14-2-13-32-15-9-22(10-16-32)19-21-3-5-24(31)6-4-21/h3-8,20,22-23H,2,9-19H2,1H3
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50088319
PNG
(CHEMBL62339 | Dimethyl-(4-{[3-(4-piperidin-1-yl-ph...)
Show SMILES C[N+](C)(Cc1ccc(NC(=O)C2=Cc3cc(ccc3CCC2)-c2ccc(cc2)N2CCCCC2)cc1)C1CCOCC1 |t:11|
Show InChI InChI=1S/C37H45N3O2/c1-40(2,36-19-23-42-24-20-36)27-28-9-15-34(16-10-28)38-37(41)32-8-6-7-29-11-12-31(25-33(29)26-32)30-13-17-35(18-14-30)39-21-4-3-5-22-39/h9-18,25-26,36H,3-8,19-24,27H2,1-2H3/p+1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES


J Med Chem 43: 2049-63 (2000)


BindingDB Entry DOI: 10.7270/Q26D5S75
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185967
PNG
(CHEMBL207487 | N-(3-(4-(4-(methylsulfonyl)benzyl)p...)
Show SMILES CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccc(cc2)S(C)(=O)=O)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H39Cl2N3O5S2/c1-40(36,37)26-7-4-22(5-8-26)20-23-10-16-32(17-11-23)14-3-15-34(25-6-9-27(30)28(31)21-25)29(35)24-12-18-33(19-13-24)41(2,38)39/h4-9,21,23-24H,3,10-20H2,1-2H3
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185978
PNG
(1-acetyl-N-{3-[4-(4-carbamoylbenzyl)piperidin-1-yl...)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccc(cc2)C(N)=O)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C30H38Cl2N4O3/c1-21(37)35-17-11-25(12-18-35)30(39)36(26-7-8-27(31)28(32)20-26)14-2-13-34-15-9-23(10-16-34)19-22-3-5-24(6-4-22)29(33)38/h3-8,20,23,25H,2,9-19H2,1H3,(H2,33,38)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185975
PNG
(1-acetyl-N-(3,4-dichlorophenyl)-N-(3-{4-[(4-fluoro...)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(CC1)S(=O)c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C28H34Cl2FN3O3S/c1-20(35)33-17-9-21(10-18-33)28(36)34(23-5-8-26(29)27(30)19-23)14-2-13-32-15-11-25(12-16-32)38(37)24-6-3-22(31)4-7-24/h3-8,19,21,25H,2,9-18H2,1H3
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185964
PNG
(CHEMBL382252 | N-{3-[4-(3-carbamoylbenzyl)piperidi...)
Show SMILES CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2cccc(c2)C(N)=O)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H38Cl2N4O4S/c1-40(38,39)34-16-10-23(11-17-34)29(37)35(25-6-7-26(30)27(31)20-25)13-3-12-33-14-8-21(9-15-33)18-22-4-2-5-24(19-22)28(32)36/h2,4-7,19-21,23H,3,8-18H2,1H3,(H2,32,36)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185968
PNG
(1-acetyl-N-(3,4-dichlorophenyl)-N-(3-{4-[(4-fluoro...)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(CC1)S(=O)(=O)c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C28H34Cl2FN3O4S/c1-20(35)33-17-9-21(10-18-33)28(36)34(23-5-8-26(29)27(30)19-23)14-2-13-32-15-11-25(12-16-32)39(37,38)24-6-3-22(31)4-7-24/h3-8,19,21,25H,2,9-18H2,1H3
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185972
PNG
(CHEMBL207182 | N-(3-(4-(4-fluorobenzyl)piperidin-1...)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H36Cl2FN3O2/c1-21(36)34-17-11-24(12-18-34)29(37)35(26-7-8-27(30)28(31)20-26)14-2-13-33-15-9-23(10-16-33)19-22-3-5-25(32)6-4-22/h3-8,20,23-24H,2,9-19H2,1H3
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50088311
PNG
(CHEMBL61208 | Dimethyl-(tetrahydro-thiopyran-4-yl)...)
Show SMILES Cc1ccc(cc1)-c1ccc2OCCC(=Cc2c1)C(=O)Nc1ccc(C[N+](C)(C)C2CCSCC2)cc1 |c:15|
Show InChI InChI=1S/C32H36N2O2S/c1-23-4-8-25(9-5-23)26-10-13-31-28(20-26)21-27(14-17-36-31)32(35)33-29-11-6-24(7-12-29)22-34(2,3)30-15-18-37-19-16-30/h4-13,20-21,30H,14-19,22H2,1-3H3/p+1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES


J Med Chem 43: 2049-63 (2000)


BindingDB Entry DOI: 10.7270/Q26D5S75
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185975
PNG
(1-acetyl-N-(3,4-dichlorophenyl)-N-(3-{4-[(4-fluoro...)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(CC1)S(=O)c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C28H34Cl2FN3O3S/c1-20(35)33-17-9-21(10-18-33)28(36)34(23-5-8-26(29)27(30)19-23)14-2-13-32-15-11-25(12-16-32)38(37)24-6-3-22(31)4-7-24/h3-8,19,21,25H,2,9-18H2,1H3
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50088306
PNG
((1-Ethyl-propyl)-dimethyl-{4-[(7-p-tolyl-2,3-dihyd...)
Show SMILES CCC(CC)[N+](C)(C)Cc1ccc(NC(=O)C2=Cc3cc(ccc3OCC2)-c2ccc(C)cc2)cc1 |t:16|
Show InChI InChI=1S/C32H38N2O2/c1-6-30(7-2)34(4,5)22-24-10-15-29(16-11-24)33-32(35)27-18-19-36-31-17-14-26(20-28(31)21-27)25-12-8-23(3)9-13-25/h8-17,20-21,30H,6-7,18-19,22H2,1-5H3/p+1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES


J Med Chem 43: 2049-63 (2000)


BindingDB Entry DOI: 10.7270/Q26D5S75
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185961
PNG
(CHEMBL207190 | N-(3-(4-(4-fluorobenzyl)piperidin-1...)
Show SMILES CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C28H36Cl2FN3O3S/c1-38(36,37)33-17-11-23(12-18-33)28(35)34(25-7-8-26(29)27(30)20-25)14-2-13-32-15-9-22(10-16-32)19-21-3-5-24(31)6-4-21/h3-8,20,22-23H,2,9-19H2,1H3
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185979
PNG
(1-acetyl-N-{3-[4-(4-carbamoylbenzyl)piperidin-1-yl...)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccc(cc2)C(N)=O)CC1)c1ccc(C)c(Cl)c1
Show InChI InChI=1S/C31H41ClN4O3/c1-22-4-9-28(21-29(22)32)36(31(39)27-12-18-35(19-13-27)23(2)37)15-3-14-34-16-10-25(11-17-34)20-24-5-7-26(8-6-24)30(33)38/h4-9,21,25,27H,3,10-20H2,1-2H3,(H2,33,38)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185978
PNG
(1-acetyl-N-{3-[4-(4-carbamoylbenzyl)piperidin-1-yl...)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccc(cc2)C(N)=O)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C30H38Cl2N4O3/c1-21(37)35-17-11-25(12-18-35)30(39)36(26-7-8-27(31)28(32)20-26)14-2-13-34-15-9-23(10-16-34)19-22-3-5-24(6-4-22)29(33)38/h3-8,20,23,25H,2,9-19H2,1H3,(H2,33,38)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50088312
PNG
(CHEMBL62180 | Dimethyl-(4-{[3-(4-pyrrolidin-1-yl-p...)
Show SMILES C[N+](C)(Cc1ccc(NC(=O)C2=Cc3cc(ccc3CCC2)-c2ccc(cc2)N2CCCC2)cc1)C1CCOCC1 |t:11|
Show InChI InChI=1S/C36H43N3O2/c1-39(2,35-18-22-41-23-19-35)26-27-8-14-33(15-9-27)37-36(40)31-7-5-6-28-10-11-30(24-32(28)25-31)29-12-16-34(17-13-29)38-20-3-4-21-38/h8-17,24-25,35H,3-7,18-23,26H2,1-2H3/p+1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES


J Med Chem 43: 2049-63 (2000)


BindingDB Entry DOI: 10.7270/Q26D5S75
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185968
PNG
(1-acetyl-N-(3,4-dichlorophenyl)-N-(3-{4-[(4-fluoro...)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(CC1)S(=O)(=O)c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C28H34Cl2FN3O4S/c1-20(35)33-17-9-21(10-18-33)28(36)34(23-5-8-26(29)27(30)19-23)14-2-13-32-15-11-25(12-16-32)39(37,38)24-6-3-22(31)4-7-24/h3-8,19,21,25H,2,9-18H2,1H3
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185971
PNG
(CHEMBL207447 | N-(3,4-dichlorophenyl)-N-[3-(4-{[(4...)
Show SMILES CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(CC1)NS(=O)(=O)c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C27H35Cl2FN4O5S2/c1-40(36,37)33-17-9-20(10-18-33)27(35)34(23-5-8-25(28)26(29)19-23)14-2-13-32-15-11-22(12-16-32)31-41(38,39)24-6-3-21(30)4-7-24/h3-8,19-20,22,31H,2,9-18H2,1H3
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50088325
PNG
(CHEMBL62598 | Dimethyl-(4-oxo-cyclohexyl)-{4-[(7-p...)
Show SMILES Cc1ccc(cc1)-c1ccc2OCCC(=Cc2c1)C(=O)Nc1ccc(C[N+](C)(C)C2CCC(=O)CC2)cc1 |c:15|
Show InChI InChI=1S/C33H36N2O3/c1-23-4-8-25(9-5-23)26-10-17-32-28(20-26)21-27(18-19-38-32)33(37)34-29-11-6-24(7-12-29)22-35(2,3)30-13-15-31(36)16-14-30/h4-12,17,20-21,30H,13-16,18-19,22H2,1-3H3/p+1
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES


J Med Chem 43: 2049-63 (2000)


BindingDB Entry DOI: 10.7270/Q26D5S75
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185970
PNG
(CHEMBL207301 | methyl 4-({1-[3-((3,4-Dichloropheny...)
Show SMILES COC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(CC3)S(C)(=O)=O)c3ccc(Cl)c(Cl)c3)CC2)cc1
Show InChI InChI=1S/C30H39Cl2N3O5S/c1-40-30(37)25-6-4-22(5-7-25)20-23-10-16-33(17-11-23)14-3-15-35(26-8-9-27(31)28(32)21-26)29(36)24-12-18-34(19-13-24)41(2,38)39/h4-9,21,23-24H,3,10-20H2,1-2H3
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185971
PNG
(CHEMBL207447 | N-(3,4-dichlorophenyl)-N-[3-(4-{[(4...)
Show SMILES CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(CC1)NS(=O)(=O)c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C27H35Cl2FN4O5S2/c1-40(36,37)33-17-9-20(10-18-33)27(35)34(23-5-8-25(28)26(29)19-23)14-2-13-32-15-11-22(12-16-32)31-41(38,39)24-6-3-21(30)4-7-24/h3-8,19-20,22,31H,2,9-18H2,1H3
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185969
PNG
(CHEMBL264832 | N-(3,4-dichlorophenyl)-N-(3-{4-[4-(...)
Show SMILES CNC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(CC3)S(C)(=O)=O)c3ccc(Cl)c(Cl)c3)CC2)cc1
Show InChI InChI=1S/C30H40Cl2N4O4S/c1-33-29(37)24-6-4-22(5-7-24)20-23-10-16-34(17-11-23)14-3-15-36(26-8-9-27(31)28(32)21-26)30(38)25-12-18-35(19-13-25)41(2,39)40/h4-9,21,23,25H,3,10-20H2,1-2H3,(H,33,37)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185980
PNG
(CHEMBL207485 | N-{3-[4-(4-carbamoylbenzyl)piperidi...)
Show SMILES CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccc(cc2)C(N)=O)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H38Cl2N4O4S/c1-40(38,39)34-17-11-24(12-18-34)29(37)35(25-7-8-26(30)27(31)20-25)14-2-13-33-15-9-22(10-16-33)19-21-3-5-23(6-4-21)28(32)36/h3-8,20,22,24H,2,9-19H2,1H3,(H2,32,36)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185966
PNG
(CHEMBL206088 | N-{3-[4-(2-carbamoylbenzyl)piperidi...)
Show SMILES CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccccc2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H38Cl2N4O4S/c1-40(38,39)34-17-11-22(12-18-34)29(37)35(24-7-8-26(30)27(31)20-24)14-4-13-33-15-9-21(10-16-33)19-23-5-2-3-6-25(23)28(32)36/h2-3,5-8,20-22H,4,9-19H2,1H3,(H2,32,36)
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n/an/a 6.40n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50088315
PNG
((3-Hydroxy-propyl)-dimethyl-{4-[(7-p-tolyl-2,3-dih...)
Show SMILES Cc1ccc(cc1)-c1ccc2OCCC(=Cc2c1)C(=O)Nc1ccc(C[N+](C)(C)CCCO)cc1 |c:15|
Show InChI InChI=1S/C30H34N2O3/c1-22-5-9-24(10-6-22)25-11-14-29-27(19-25)20-26(15-18-35-29)30(34)31-28-12-7-23(8-13-28)21-32(2,3)16-4-17-33/h5-14,19-20,33H,4,15-18,21H2,1-3H3/p+1
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n/an/a 6.80n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES


J Med Chem 43: 2049-63 (2000)


BindingDB Entry DOI: 10.7270/Q26D5S75
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185970
PNG
(CHEMBL207301 | methyl 4-({1-[3-((3,4-Dichloropheny...)
Show SMILES COC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(CC3)S(C)(=O)=O)c3ccc(Cl)c(Cl)c3)CC2)cc1
Show InChI InChI=1S/C30H39Cl2N3O5S/c1-40-30(37)25-6-4-22(5-7-25)20-23-10-16-33(17-11-23)14-3-15-35(26-8-9-27(31)28(32)21-26)29(36)24-12-18-34(19-13-24)41(2,38)39/h4-9,21,23-24H,3,10-20H2,1-2H3
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n/an/a 7n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185976
PNG
(CHEMBL205706 | N-(3,4-dichlorophenyl)-N-(3-{4-[4-(...)
Show SMILES CN(C)C(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(CC3)S(C)(=O)=O)c3ccc(Cl)c(Cl)c3)CC2)cc1
Show InChI InChI=1S/C31H42Cl2N4O4S/c1-34(2)30(38)25-7-5-23(6-8-25)21-24-11-17-35(18-12-24)15-4-16-37(27-9-10-28(32)29(33)22-27)31(39)26-13-19-36(20-14-26)42(3,40)41/h5-10,22,24,26H,4,11-21H2,1-3H3
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n/an/a 8.20n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185980
PNG
(CHEMBL207485 | N-{3-[4-(4-carbamoylbenzyl)piperidi...)
Show SMILES CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccc(cc2)C(N)=O)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H38Cl2N4O4S/c1-40(38,39)34-17-11-24(12-18-34)29(37)35(25-7-8-26(30)27(31)20-25)14-2-13-33-15-9-22(10-16-33)19-21-3-5-23(6-4-21)28(32)36/h3-8,20,22,24H,2,9-19H2,1H3,(H2,32,36)
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n/an/a 8.90n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185969
PNG
(CHEMBL264832 | N-(3,4-dichlorophenyl)-N-(3-{4-[4-(...)
Show SMILES CNC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(CC3)S(C)(=O)=O)c3ccc(Cl)c(Cl)c3)CC2)cc1
Show InChI InChI=1S/C30H40Cl2N4O4S/c1-33-29(37)24-6-4-22(5-7-24)20-23-10-16-34(17-11-23)14-3-15-36(26-8-9-27(31)28(32)21-26)30(38)25-12-18-35(19-13-25)41(2,39)40/h4-9,21,23,25H,3,10-20H2,1-2H3,(H,33,37)
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n/an/a 9.80n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185974
PNG
(CHEMBL205964 | N-(3-{4-[4-(tert-butylcarbamoyl)ben...)
Show SMILES CC(C)(C)NC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(CC3)S(C)(=O)=O)c3ccc(Cl)c(Cl)c3)CC2)cc1
Show InChI InChI=1S/C33H46Cl2N4O4S/c1-33(2,3)36-31(40)26-8-6-24(7-9-26)22-25-12-18-37(19-13-25)16-5-17-39(28-10-11-29(34)30(35)23-28)32(41)27-14-20-38(21-15-27)44(4,42)43/h6-11,23,25,27H,5,12-22H2,1-4H3,(H,36,40)
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n/an/a 11n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185974
PNG
(CHEMBL205964 | N-(3-{4-[4-(tert-butylcarbamoyl)ben...)
Show SMILES CC(C)(C)NC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(CC3)S(C)(=O)=O)c3ccc(Cl)c(Cl)c3)CC2)cc1
Show InChI InChI=1S/C33H46Cl2N4O4S/c1-33(2,3)36-31(40)26-8-6-24(7-9-26)22-25-12-18-37(19-13-25)16-5-17-39(28-10-11-29(34)30(35)23-28)32(41)27-14-20-38(21-15-27)44(4,42)43/h6-11,23,25,27H,5,12-22H2,1-4H3,(H,36,40)
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n/an/a 12n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185966
PNG
(CHEMBL206088 | N-{3-[4-(2-carbamoylbenzyl)piperidi...)
Show SMILES CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccccc2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H38Cl2N4O4S/c1-40(38,39)34-17-11-22(12-18-34)29(37)35(24-7-8-26(30)27(31)20-24)14-4-13-33-15-9-21(10-16-33)19-23-5-2-3-6-25(23)28(32)36/h2-3,5-8,20-22H,4,9-19H2,1H3,(H2,32,36)
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n/an/a 12n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185960
PNG
(1-acetyl-N-(3-(4-benzylpiperidin-1-yl)propyl)-N-ph...)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N3O2/c1-24(33)31-21-15-27(16-22-31)29(34)32(28-11-6-3-7-12-28)18-8-17-30-19-13-26(14-20-30)23-25-9-4-2-5-10-25/h2-7,9-12,26-27H,8,13-23H2,1H3
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n/an/a 16n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185976
PNG
(CHEMBL205706 | N-(3,4-dichlorophenyl)-N-(3-{4-[4-(...)
Show SMILES CN(C)C(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(CC3)S(C)(=O)=O)c3ccc(Cl)c(Cl)c3)CC2)cc1
Show InChI InChI=1S/C31H42Cl2N4O4S/c1-34(2)30(38)25-7-5-23(6-8-25)21-24-11-17-35(18-12-24)15-4-16-37(27-9-10-28(32)29(33)22-27)31(39)26-13-19-36(20-14-26)42(3,40)41/h5-10,22,24,26H,4,11-21H2,1-3H3
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n/an/a 19n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185965
PNG
(1-acetyl-N-(3,4-dichlorophenyl)-N-{3-[4-(4-fluoroa...)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(CC1)Nc1ccc(F)cc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C28H35Cl2FN4O2/c1-20(36)34-17-9-21(10-18-34)28(37)35(25-7-8-26(29)27(30)19-25)14-2-13-33-15-11-24(12-16-33)32-23-5-3-22(31)4-6-23/h3-8,19,21,24,32H,2,9-18H2,1H3
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n/an/a 20n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50088320
PNG
(1-Methyl-1-{4-[(3-p-tolyl-8,9-dihydro-7H-benzocycl...)
Show SMILES Cc1ccc(cc1)-c1ccc2CCCC(=Cc2c1)C(=O)Nc1ccc(C[N+]2(C)CCCCC2)cc1 |c:15|
Show InChI InChI=1S/C32H36N2O/c1-24-9-13-27(14-10-24)28-16-15-26-7-6-8-29(22-30(26)21-28)32(35)33-31-17-11-25(12-18-31)23-34(2)19-4-3-5-20-34/h9-18,21-22H,3-8,19-20,23H2,1-2H3/p+1
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n/an/a 25n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES


J Med Chem 43: 2049-63 (2000)


BindingDB Entry DOI: 10.7270/Q26D5S75
More data for this
Ligand-Target Pair
C-C chemokine receptor type 5


(Homo sapiens (Human))
BDBM50185965
PNG
(1-acetyl-N-(3,4-dichlorophenyl)-N-{3-[4-(4-fluoroa...)
Show SMILES CC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(CC1)Nc1ccc(F)cc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C28H35Cl2FN4O2/c1-20(36)34-17-9-21(10-18-34)28(37)35(25-7-8-26(29)27(30)19-25)14-2-13-33-15-11-24(12-16-33)32-23-5-3-22(31)4-6-23/h3-8,19,21,24,32H,2,9-18H2,1H3
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n/an/a 26n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5


J Med Chem 49: 2784-93 (2006)


Article DOI: 10.1021/jm051034q
BindingDB Entry DOI: 10.7270/Q2ZK5G8F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50088301
PNG
((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Show SMILES Cc1ccc(cc1)-c1ccc2CCCC(=Cc2c1)C(=O)Nc1ccc(C[N+](C)(C)C2CCOCC2)cc1 |c:15|
Show InChI InChI=1S/C33H38N2O2/c1-24-7-11-27(12-8-24)28-14-13-26-5-4-6-29(22-30(26)21-28)33(36)34-31-15-9-25(10-16-31)23-35(2,3)32-17-19-37-20-18-32/h7-16,21-22,32H,4-6,17-20,23H2,1-3H3/p+1
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n/an/a 27n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect of the compound on the binding of [125I]- MCP-1 to C-C chemokine receptor type 2-expressing CHO cells


J Med Chem 43: 2049-63 (2000)


BindingDB Entry DOI: 10.7270/Q26D5S75
More data for this
Ligand-Target Pair
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