new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 208 hits with Last Name = 'nixon' and Initial = 'js'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Collagenase


(Homo sapiens (Human))
BDBM50290085
PNG
((2S,3R)-N*4*-((R)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)[C@@H](CN1C(=O)c2ccccc2C1=O)C(=O)NO)C(C)(C)C
Show InChI InChI=1S/C24H34N4O6/c1-13(2)11-16(19(29)26-18(21(31)25-6)24(3,4)5)17(20(30)27-34)12-28-22(32)14-9-7-8-10-15(14)23(28)33/h7-10,13,16-18,34H,11-12H2,1-6H3,(H,25,31)(H,26,29)(H,27,30)/t16-,17-,18+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 0.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)


Bioorg Med Chem Lett 7: 2299-2302 (1997)


Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50290088
PNG
((2S,3R)-N*1*-((R)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)[C@@H](CN1C(=O)N(C)C(C)(C)C1=O)C(=O)NO)C(C)(C)C
Show InChI InChI=1S/C22H39N5O6/c1-12(2)10-13(16(28)24-15(18(30)23-8)21(3,4)5)14(17(29)25-33)11-27-19(31)22(6,7)26(9)20(27)32/h12-15,33H,10-11H2,1-9H3,(H,23,30)(H,24,28)(H,25,29)/t13-,14-,15+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 1n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)


Bioorg Med Chem Lett 7: 2299-2302 (1997)


Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM50290089
PNG
((2R,3R)-N*1*-[2,2-Dimethyl-1-((R)-methylcarbamoyl)...)
Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)[C@@H](C)C(=O)NO)C(C)(C)C
Show InChI InChI=1S/C16H31N3O4/c1-9(2)8-11(10(3)13(20)19-23)14(21)18-12(15(22)17-7)16(4,5)6/h9-12,23H,8H2,1-7H3,(H,17,22)(H,18,21)(H,19,20)/t10-,11-,12+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 2.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human gelatinase B, MMP9


Bioorg Med Chem Lett 7: 2299-2302 (1997)


Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50290089
PNG
((2R,3R)-N*1*-[2,2-Dimethyl-1-((R)-methylcarbamoyl)...)
Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)[C@@H](C)C(=O)NO)C(C)(C)C
Show InChI InChI=1S/C16H31N3O4/c1-9(2)8-11(10(3)13(20)19-23)14(21)18-12(15(22)17-7)16(4,5)6/h9-12,23H,8H2,1-7H3,(H,17,22)(H,18,21)(H,19,20)/t10-,11-,12+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 2.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)


Bioorg Med Chem Lett 7: 2299-2302 (1997)


Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM50290088
PNG
((2S,3R)-N*1*-((R)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)[C@@H](CN1C(=O)N(C)C(C)(C)C1=O)C(=O)NO)C(C)(C)C
Show InChI InChI=1S/C22H39N5O6/c1-12(2)10-13(16(28)24-15(18(30)23-8)21(3,4)5)14(17(29)25-33)11-27-19(31)22(6,7)26(9)20(27)32/h12-15,33H,10-11H2,1-9H3,(H,23,30)(H,24,28)(H,25,29)/t13-,14-,15+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 2.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human gelatinase B, MMP9


Bioorg Med Chem Lett 7: 2299-2302 (1997)


Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50282632
PNG
(3-((3aR,10aR)-2-Methyl-2,3,3a,4,10,10a-hexahydro-1...)
Show SMILES CN1C[C@@H]2Cc3c(C4=C(C(=O)NC4=O)c4cn(C)c5ccccc45)c4ccccc4n3C[C@H]2C1 |r,t:7|
Show InChI InChI=1S/C28H26N4O2/c1-30-12-16-11-23-24(19-8-4-6-10-22(19)32(23)14-17(16)13-30)26-25(27(33)29-28(26)34)20-15-31(2)21-9-5-3-7-18(20)21/h3-10,15-17H,11-14H2,1-2H3,(H,29,33,34)/t16-,17+/m0/s1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 2.85n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C alpha


Bioorg Med Chem Lett 4: 1303-1308 (1994)


Article DOI: 10.1016/S0960-894X(01)80349-8
BindingDB Entry DOI: 10.7270/Q27H1JJ4
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2714
PNG
(3-[(2S)-2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3C[C@@H](CN)CCn3c3ccccc23)c2ccccc12 |r,t:4|
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.10n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm034033b
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM50290085
PNG
((2S,3R)-N*4*-((R)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)[C@@H](CN1C(=O)c2ccccc2C1=O)C(=O)NO)C(C)(C)C
Show InChI InChI=1S/C24H34N4O6/c1-13(2)11-16(19(29)26-18(21(31)25-6)24(3,4)5)17(20(30)27-34)12-28-22(32)14-9-7-8-10-15(14)23(28)33/h7-10,13,16-18,34H,11-12H2,1-6H3,(H,25,31)(H,26,29)(H,27,30)/t16-,17-,18+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 4.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human gelatinase B, MMP9


Bioorg Med Chem Lett 7: 2299-2302 (1997)


Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50290086
PNG
((R)-N*1*-[2,2-Dimethyl-1-((R)-methylcarbamoyl)-pro...)
Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)CC(=O)NO)C(C)(C)C
Show InChI InChI=1S/C15H29N3O4/c1-9(2)7-10(8-11(19)18-22)13(20)17-12(14(21)16-6)15(3,4)5/h9-10,12,22H,7-8H2,1-6H3,(H,16,21)(H,17,20)(H,18,19)/t10-,12+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 4.90n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)


Bioorg Med Chem Lett 7: 2299-2302 (1997)


Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM50282632
PNG
(3-((3aR,10aR)-2-Methyl-2,3,3a,4,10,10a-hexahydro-1...)
Show SMILES CN1C[C@@H]2Cc3c(C4=C(C(=O)NC4=O)c4cn(C)c5ccccc45)c4ccccc4n3C[C@H]2C1 |r,t:7|
Show InChI InChI=1S/C28H26N4O2/c1-30-12-16-11-23-24(19-8-4-6-10-22(19)32(23)14-17(16)13-30)26-25(27(33)29-28(26)34)20-15-31(2)21-9-5-3-7-18(20)21/h3-10,15-17H,11-14H2,1-2H3,(H,29,33,34)/t16-,17+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 5.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C beta 1


Bioorg Med Chem Lett 4: 1303-1308 (1994)


Article DOI: 10.1016/S0960-894X(01)80349-8
BindingDB Entry DOI: 10.7270/Q27H1JJ4
More data for this
Ligand-Target Pair
Protein kinase C gamma


(Rattus norvegicus)
BDBM50282632
PNG
(3-((3aR,10aR)-2-Methyl-2,3,3a,4,10,10a-hexahydro-1...)
Show SMILES CN1C[C@@H]2Cc3c(C4=C(C(=O)NC4=O)c4cn(C)c5ccccc45)c4ccccc4n3C[C@H]2C1 |r,t:7|
Show InChI InChI=1S/C28H26N4O2/c1-30-12-16-11-23-24(19-8-4-6-10-22(19)32(23)14-17(16)13-30)26-25(27(33)29-28(26)34)20-15-31(2)21-9-5-3-7-18(20)21/h3-10,15-17H,11-14H2,1-2H3,(H,29,33,34)/t16-,17+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 5.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C gamma (PKC)


Bioorg Med Chem Lett 4: 1303-1308 (1994)


Article DOI: 10.1016/S0960-894X(01)80349-8
BindingDB Entry DOI: 10.7270/Q27H1JJ4
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM50282632
PNG
(3-((3aR,10aR)-2-Methyl-2,3,3a,4,10,10a-hexahydro-1...)
Show SMILES CN1C[C@@H]2Cc3c(C4=C(C(=O)NC4=O)c4cn(C)c5ccccc45)c4ccccc4n3C[C@H]2C1 |r,t:7|
Show InChI InChI=1S/C28H26N4O2/c1-30-12-16-11-23-24(19-8-4-6-10-22(19)32(23)14-17(16)13-30)26-25(27(33)29-28(26)34)20-15-31(2)21-9-5-3-7-18(20)21/h3-10,15-17H,11-14H2,1-2H3,(H,29,33,34)/t16-,17+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 6.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C beta


Bioorg Med Chem Lett 4: 1303-1308 (1994)


Article DOI: 10.1016/S0960-894X(01)80349-8
BindingDB Entry DOI: 10.7270/Q27H1JJ4
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50290090
PNG
((2S,3R)-3-Cyclopentylmethyl-N-hydroxy-4-oxo-4-pipe...)
Show SMILES CN1C(=O)N(C[C@H]([C@@H](CC2CCCC2)C(=O)N2CCCCC2)C(=O)NO)C(=O)C1(C)C
Show InChI InChI=1S/C22H36N4O5/c1-22(2)20(29)26(21(30)24(22)3)14-17(18(27)23-31)16(13-15-9-5-6-10-15)19(28)25-11-7-4-8-12-25/h15-17,31H,4-14H2,1-3H3,(H,23,27)/t16-,17-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 7n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)


Bioorg Med Chem Lett 7: 2299-2302 (1997)


Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2700
PNG
(3-[2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(CN)CCn3c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 7.60n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm034033b
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50282633
PNG
((S)-3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydr...)
Show SMILES CN(C)C[C@H]1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1cn(C)c3ccccc13)c1ccccc21 |t:12|
Show InChI InChI=1S/C28H28N4O2/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34)/t17-/m0/s1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
n/an/a 8.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C alpha


Bioorg Med Chem Lett 4: 1303-1308 (1994)


Article DOI: 10.1016/S0960-894X(01)80349-8
BindingDB Entry DOI: 10.7270/Q27H1JJ4
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a 9n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm034033b
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a 9n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1016/j.bmc.2005.03.050
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50290085
PNG
((2S,3R)-N*4*-((R)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)[C@@H](CN1C(=O)c2ccccc2C1=O)C(=O)NO)C(C)(C)C
Show InChI InChI=1S/C24H34N4O6/c1-13(2)11-16(19(29)26-18(21(31)25-6)24(3,4)5)17(20(30)27-34)12-28-22(32)14-9-7-8-10-15(14)23(28)33/h7-10,13,16-18,34H,11-12H2,1-6H3,(H,25,31)(H,26,29)(H,27,30)/t16-,17-,18+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 9.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human stromelysin-1, MMP-3


Bioorg Med Chem Lett 7: 2299-2302 (1997)


Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2712
PNG
(3-(1-methyl-1H-indol-3-yl)-4-{2-[(methylamino)meth...)
Show SMILES CNCC1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1cn(C)c3ccccc13)c1ccccc21 |t:11|
Show InChI InChI=1S/C27H26N4O2/c1-28-14-16-11-12-31-21-10-6-4-8-18(21)23(22(31)13-16)25-24(26(32)29-27(25)33)19-15-30(2)20-9-5-3-7-17(19)20/h3-10,15-16,28H,11-14H2,1-2H3,(H,29,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9.80n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm034033b
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2715
PNG
(3-[(2R)-2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3C[C@H](CN)CCn3c3ccccc23)c2ccccc12 |r,t:4|
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm034033b
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3175
PNG
(3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methy...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCSC(N)=N)c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C25H23N5O2S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50290087
PNG
((2S,3R)-5-Methyl-3-(piperidine-1-carbonyl)-2-(3,4,...)
Show SMILES CC(C)C[C@H]([C@@H](CN1C(=O)N(C)C(C)(C)C1=O)C(=O)NO)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H34N4O5/c1-13(2)11-14(17(26)23-9-7-6-8-10-23)15(16(25)21-29)12-24-18(27)20(3,4)22(5)19(24)28/h13-15,29H,6-12H2,1-5H3,(H,21,25)/t14-,15-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)


Bioorg Med Chem Lett 7: 2299-2302 (1997)


Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM50290086
PNG
((R)-N*1*-[2,2-Dimethyl-1-((R)-methylcarbamoyl)-pro...)
Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)CC(=O)NO)C(C)(C)C
Show InChI InChI=1S/C15H29N3O4/c1-9(2)7-10(8-11(19)18-22)13(20)17-12(14(21)16-6)15(3,4)5/h9-10,12,22H,7-8H2,1-6H3,(H,16,21)(H,17,20)(H,18,19)/t10-,12+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human gelatinase B, MMP9


Bioorg Med Chem Lett 7: 2299-2302 (1997)


Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2699
PNG
(3-[2-(aminomethyl)-1H,2H,3H-benzo[b]pyrrolizin-9-y...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(CN)Cn3c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C25H22N4O2/c1-28-13-17(15-6-2-4-8-18(15)28)22-23(25(31)27-24(22)30)21-16-7-3-5-9-19(16)29-12-14(11-26)10-20(21)29/h2-9,13-14H,10-12,26H2,1H3,(H,27,30,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 14n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm034033b
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2702
PNG
(3-[3-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCC(CN)Cn3c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-13-15(12-27)10-11-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 15n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm034033b
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2704
PNG
(3-[8-(aminomethyl)-6H,7H,8H,9H,10H-azepino[1,2-a]i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCC(CN)CCn3c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C27H26N4O2/c1-30-15-19(17-6-2-4-8-20(17)30)24-25(27(33)29-26(24)32)23-18-7-3-5-9-21(18)31-13-12-16(14-28)10-11-22(23)31/h2-9,15-16H,10-14,28H2,1H3,(H,29,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 16.5n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm034033b
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3179
PNG
(3-(3-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-...)
Show SMILES [#6]-n1cc(-[#6]-2=[#6](-[#6](=O)-[#7]-[#6]-2=O)-c2cn(-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C25H24N6O2/c1-30-13-17(15-7-2-4-9-19(15)30)21-22(24(33)29-23(21)32)18-14-31(12-6-11-28-25(26)27)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12H2,1H3,(H4,26,27,28)(H,29,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 19n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2703
PNG
(3-[3-(2-aminoethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCC(CCN)Cn3c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C27H26N4O2/c1-30-15-19(17-6-2-4-8-20(17)30)24-25(27(33)29-26(24)32)23-18-7-3-5-9-21(18)31-14-16(12-13-28)10-11-22(23)31/h2-9,15-16H,10-14,28H2,1H3,(H,29,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 23n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm034033b
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3178
PNG
(3-(1-Methyl-3-indolyl)-4-[1-[3-(2-nitroguanidino)p...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCN=C(N)N[N+]([O-])=O)c3ccccc23)c2ccccc12 |w:17.17,t:4|
Show InChI InChI=1S/C25H23N7O4/c1-30-13-17(15-7-2-4-9-19(15)30)21-22(24(34)28-23(21)33)18-14-31(20-10-5-3-8-16(18)20)12-6-11-27-25(26)29-32(35)36/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27,29)(H,28,33,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 26n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM50282633
PNG
((S)-3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydr...)
Show SMILES CN(C)C[C@H]1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1cn(C)c3ccccc13)c1ccccc21 |t:12|
Show InChI InChI=1S/C28H28N4O2/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34)/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
n/an/a 28n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C beta 1


Bioorg Med Chem Lett 4: 1303-1308 (1994)


Article DOI: 10.1016/S0960-894X(01)80349-8
BindingDB Entry DOI: 10.7270/Q27H1JJ4
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3176
PNG
(Bisindolylmaleimide 11c | [(4-{3-[4-(1-methyl-1H-i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCCSC(N)=N)c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C26H25N5O2S/c1-30-14-18(16-8-2-4-10-20(16)30)22-23(25(33)29-24(22)32)19-15-31(12-6-7-13-34-26(27)28)21-11-5-3-9-17(19)21/h2-5,8-11,14-15H,6-7,12-13H2,1H3,(H3,27,28)(H,29,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 28n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM50282633
PNG
((S)-3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydr...)
Show SMILES CN(C)C[C@H]1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1cn(C)c3ccccc13)c1ccccc21 |t:12|
Show InChI InChI=1S/C28H28N4O2/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34)/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
n/an/a 30.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C beta


Bioorg Med Chem Lett 4: 1303-1308 (1994)


Article DOI: 10.1016/S0960-894X(01)80349-8
BindingDB Entry DOI: 10.7270/Q27H1JJ4
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3180
PNG
(3-[1-(4-Amidinobutyl)-3-indolyl]-4-(1-methyl-3-ind...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCCC(N)=N)c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C26H25N5O2/c1-30-14-18(16-8-2-4-10-20(16)30)23-24(26(33)29-25(23)32)19-15-31(13-7-6-12-22(27)28)21-11-5-3-9-17(19)21/h2-5,8-11,14-15H,6-7,12-13H2,1H3,(H3,27,28)(H,29,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 31n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3171
PNG
(3-(1-methyl-1H-indol-3-yl)-4-{1-[3-(methylamino)pr...)
Show SMILES CNCCCn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12 |t:8|
Show InChI InChI=1S/C25H24N4O2/c1-26-12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-28(2)20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 35n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein kinase C gamma


(Rattus norvegicus)
BDBM50282633
PNG
((S)-3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydr...)
Show SMILES CN(C)C[C@H]1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1cn(C)c3ccccc13)c1ccccc21 |t:12|
Show InChI InChI=1S/C28H28N4O2/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34)/t17-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
n/an/a 36.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C gamma (PKC)


Bioorg Med Chem Lett 4: 1303-1308 (1994)


Article DOI: 10.1016/S0960-894X(01)80349-8
BindingDB Entry DOI: 10.7270/Q27H1JJ4
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3174
PNG
(Bisindolylmaleimide 11a | ROCHE screening, 56 | [(...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCSC(N)=N)c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C24H21N5O2S/c1-28-12-16(14-6-2-4-8-18(14)28)20-21(23(31)27-22(20)30)17-13-29(10-11-32-24(25)26)19-9-5-3-7-15(17)19/h2-9,12-13H,10-11H2,1H3,(H3,25,26)(H,27,30,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 41n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2705
PNG
(3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyr...)
Show SMILES CN(C)CC1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1cn(C)c3ccccc13)c1ccccc21 |t:12|
Show InChI InChI=1S/C28H28N4O2/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm034033b
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2681
PNG
(3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-4-(1...)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12 |t:9|
Show InChI InChI=1S/C26H26N4O2/c1-28(2)13-8-14-30-16-20(18-10-5-7-12-22(18)30)24-23(25(31)27-26(24)32)19-15-29(3)21-11-6-4-9-17(19)21/h4-7,9-12,15-16H,8,13-14H2,1-3H3,(H,27,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 45n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3177
PNG
(Bisindolylmaleimide 11d | ROCHE screening, 58 | [(...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCCCSC(N)=N)c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C27H27N5O2S/c1-31-15-19(17-9-3-5-11-21(17)31)23-24(26(34)30-25(23)33)20-16-32(22-12-6-4-10-18(20)22)13-7-2-8-14-35-27(28)29/h3-6,9-12,15-16H,2,7-8,13-14H2,1H3,(H3,28,29)(H,30,33,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 47n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2701
PNG
(3-[2-(2-aminoethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(CCN)CCn3c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C27H26N4O2/c1-30-15-19(17-6-2-4-8-20(17)30)24-25(27(33)29-26(24)32)23-18-7-3-5-9-21(18)31-13-11-16(10-12-28)14-22(23)31/h2-9,15-16H,10-14,28H2,1H3,(H,29,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 47n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm034033b
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50290089
PNG
((2R,3R)-N*1*-[2,2-Dimethyl-1-((R)-methylcarbamoyl)...)
Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)[C@@H](C)C(=O)NO)C(C)(C)C
Show InChI InChI=1S/C16H31N3O4/c1-9(2)8-11(10(3)13(20)19-23)14(21)18-12(15(22)17-7)16(4,5)6/h9-12,23H,8H2,1-7H3,(H,17,22)(H,18,21)(H,19,20)/t10-,11-,12+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 47n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human stromelysin-1, MMP-3


Bioorg Med Chem Lett 7: 2299-2302 (1997)


Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus)
BDBM50282632
PNG
(3-((3aR,10aR)-2-Methyl-2,3,3a,4,10,10a-hexahydro-1...)
Show SMILES CN1C[C@@H]2Cc3c(C4=C(C(=O)NC4=O)c4cn(C)c5ccccc45)c4ccccc4n3C[C@H]2C1 |r,t:7|
Show InChI InChI=1S/C28H26N4O2/c1-30-12-16-11-23-24(19-8-4-6-10-22(19)32(23)14-17(16)13-30)26-25(27(33)29-28(26)34)20-15-31(2)21-9-5-3-7-18(20)21/h3-10,15-17H,11-14H2,1-2H3,(H,29,33,34)/t16-,17+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 48n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C epsilon


Bioorg Med Chem Lett 4: 1303-1308 (1994)


Article DOI: 10.1016/S0960-894X(01)80349-8
BindingDB Entry DOI: 10.7270/Q27H1JJ4
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2713
PNG
(3-[6,7,8,9-Tetrahydro-8-[(trimethylamino)methyl]py...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(C[N+](C)(C)C)CCn3c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C29H30N4O2/c1-31-16-21(19-9-5-7-11-22(19)31)26-27(29(35)30-28(26)34)25-20-10-6-8-12-23(20)32-14-13-18(15-24(25)32)17-33(2,3)4/h5-12,16,18H,13-15,17H2,1-4H3/p+1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 49n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm034033b
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3169
PNG
(3-[1-(4-aminobutyl)-1H-indol-3-yl]-4-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCCN)c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C25H24N4O2/c1-28-14-18(16-8-2-4-10-20(16)28)22-23(25(31)27-24(22)30)19-15-29(13-7-6-12-26)21-11-5-3-9-17(19)21/h2-5,8-11,14-15H,6-7,12-13,26H2,1H3,(H,27,30,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 55n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM50290090
PNG
((2S,3R)-3-Cyclopentylmethyl-N-hydroxy-4-oxo-4-pipe...)
Show SMILES CN1C(=O)N(C[C@H]([C@@H](CC2CCCC2)C(=O)N2CCCCC2)C(=O)NO)C(=O)C1(C)C
Show InChI InChI=1S/C22H36N4O5/c1-22(2)20(29)26(21(30)24(22)3)14-17(18(27)23-31)16(13-15-9-5-6-10-15)19(28)25-11-7-4-8-12-25/h15-17,31H,4-14H2,1-3H3,(H,23,27)/t16-,17-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 59n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human gelatinase B, MMP9


Bioorg Med Chem Lett 7: 2299-2302 (1997)


Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3167
PNG
(3-[1-(2-aminoethyl)-1H-indol-3-yl]-4-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCN)c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C23H20N4O2/c1-26-12-16(14-6-2-4-8-18(14)26)20-21(23(29)25-22(20)28)17-13-27(11-10-24)19-9-5-3-7-15(17)19/h2-9,12-13H,10-11,24H2,1H3,(H,25,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 64n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2695
PNG
(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCN)c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C24H22N4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a 75n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2695
PNG
(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCN)c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C24H22N4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a 75n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm034033b
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3170
PNG
(3-[1-(5-aminopentyl)-1H-indol-3-yl]-4-(1-methyl-1H...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCCCN)c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C26H26N4O2/c1-29-15-19(17-9-3-5-11-21(17)29)23-24(26(32)28-25(23)31)20-16-30(14-8-2-7-13-27)22-12-6-4-10-18(20)22/h3-6,9-12,15-16H,2,7-8,13-14,27H2,1H3,(H,28,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 76n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3173
PNG
(Bisindolylmaleimide 9 | Trimethyl[3-[3-[3-(1-methy...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCC[N+](C)(C)C)c3ccccc23)c2ccccc12 |t:4|
Show InChI InChI=1S/C27H28N4O2/c1-29-16-20(18-10-5-7-12-22(18)29)24-25(27(33)28-26(24)32)21-17-30(14-9-15-31(2,3)4)23-13-8-6-11-19(21)23/h5-8,10-13,16-17H,9,14-15H2,1-4H3/p+1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 93n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 208 total )  |  Next  |  Last  >>
Jump to: