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Compile Data Set for Download or QSAR

Found 95 hits with Last Name = 'oehme' and Initial = 'f'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118338
PNG
(US8653111, 62)
Show SMILES CC(C)(C)OC(=O)c1ccc(nc1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C15H16N6O3/c1-15(2,3)24-14(23)10-4-5-12(16-8-10)21-13(22)11(9-18-21)20-7-6-17-19-20/h4-9,18H,1-3H3
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n/an/a 50n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3527
PNG
(US8524699, 18)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCOCC1)-c1cccnc1
Show InChI InChI=1S/C16H16N6O2/c23-16-13(12-2-1-3-17-9-12)10-20-22(16)15-8-14(18-11-19-15)21-4-6-24-7-5-21/h1-3,8-11,20H,4-7H2
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n/an/a 180n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)


BindingDB Entry DOI: 10.7270/Q2TB15J4
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171824
PNG
(US9085572, 34)
Show SMILES Cc1ccnc(c1)-n1[nH]cc(-c2ccc(nc2)C#N)c1=O
Show InChI InChI=1S/C15H11N5O/c1-10-4-5-17-14(6-10)20-15(21)13(9-19-20)11-2-3-12(7-16)18-8-11/h2-6,8-9,19H,1H3
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Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)


BindingDB Entry DOI: 10.7270/Q2H70DMQ
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118341
PNG
(US8653111, 85)
Show SMILES CC(C)(C)COc1ccc(nc1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C15H18N6O2/c1-15(2,3)10-23-11-4-5-13(16-8-11)21-14(22)12(9-18-21)20-7-6-17-19-20/h4-9,18H,10H2,1-3H3
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Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM109268
PNG
(US8609698, 10)
Show SMILES OC(=O)c1ccc(nc1)-n1[nH]cc(-c2cncc(Br)c2)c1=O
Show InChI InChI=1S/C14H9BrN4O3/c15-10-3-9(4-16-6-10)11-7-18-19(13(11)20)12-2-1-8(5-17-12)14(21)22/h1-7,18H,(H,21,22)
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n/an/a 260n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...


US Patent US8609698 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NZ8
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118328
PNG
(US8653111, 7)
Show SMILES Cc1ccnc(c1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C11H10N6O/c1-8-2-3-12-10(6-8)17-11(18)9(7-14-17)16-5-4-13-15-16/h2-7,14H,1H3
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n/an/a 340n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118344
PNG
(US8653111, 103)
Show SMILES CCSc1cc(ncn1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C11H11N7OS/c1-2-20-10-5-9(12-7-13-10)18-11(19)8(6-15-18)17-4-3-14-16-17/h3-7,15H,2H2,1H3
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Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118346
PNG
(US8653111, 129)
Show SMILES CC1CCN(CC1)c1cc(ncn1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C15H18N8O/c1-11-2-5-21(6-3-11)13-8-14(17-10-16-13)23-15(24)12(9-19-23)22-7-4-18-20-22/h4,7-11,19H,2-3,5-6H2,1H3
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Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171821
PNG
(US9085572, 6)
Show SMILES O=c1c(c[nH]n1-c1ccccn1)-c1cccnc1
Show InChI InChI=1S/C13H10N4O/c18-13-11(10-4-3-6-14-8-10)9-16-17(13)12-5-1-2-7-15-12/h1-9,16H
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Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)


BindingDB Entry DOI: 10.7270/Q2H70DMQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3543
PNG
(US8524699, 16)
Show SMILES Clc1ccc(cn1)-c1c[nH]n(-c2cc(ncn2)N2CCOCC2)c1=O
Show InChI InChI=1S/C16H15ClN6O2/c17-13-2-1-11(8-18-13)12-9-21-23(16(12)24)15-7-14(19-10-20-15)22-3-5-25-6-4-22/h1-2,7-10,21H,3-6H2
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Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)


BindingDB Entry DOI: 10.7270/Q2TB15J4
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118339
PNG
(US8653111, 72)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCOCC1)-n1ccnn1
Show InChI InChI=1S/C13H14N8O2/c22-13-10(20-2-1-16-18-20)8-17-21(13)12-7-11(14-9-15-12)19-3-5-23-6-4-19/h1-2,7-9,17H,3-6H2
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n/an/a 490n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118329
PNG
(US8653111, 10)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCCC1)-n1ccnc1
Show InChI InChI=1S/C15H17N7O/c23-15-12(21-7-4-16-11-21)9-19-22(15)14-8-13(17-10-18-14)20-5-2-1-3-6-20/h4,7-11,19H,1-3,5-6H2
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n/an/a 500n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118331
PNG
(US8653111, 17)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)C1CC1)-n1ccnn1
Show InChI InChI=1S/C12H11N7O/c20-12-10(18-4-3-15-17-18)6-16-19(12)11-5-9(8-1-2-8)13-7-14-11/h3-8,16H,1-2H2
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n/an/a 560n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118347
PNG
(US8653111, 166)
Show SMILES COC1CCCN(C1)c1cc(ncn1)-n1[nH]cc(-n2ccnc2)c1=O
Show InChI InChI=1S/C16H19N7O2/c1-25-12-3-2-5-21(9-12)14-7-15(19-10-18-14)23-16(24)13(8-20-23)22-6-4-17-11-22/h4,6-8,10-12,20H,2-3,5,9H2,1H3
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n/an/a 690n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171827
PNG
(US9085572, 46)
Show SMILES O=C(Cc1ccccc1)NCc1ccnc(c1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C22H19N5O2/c28-21(12-16-5-2-1-3-6-16)25-13-17-8-10-24-20(11-17)27-22(29)19(15-26-27)18-7-4-9-23-14-18/h1-11,14-15,26H,12-13H2,(H,25,28)
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Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)


BindingDB Entry DOI: 10.7270/Q2H70DMQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3555
PNG
(US8524699, 3)
Show SMILES Cc1cc(C)n(n1)-c1cc(ncn1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C17H15N7O/c1-11-6-12(2)23(22-11)15-7-16(20-10-19-15)24-17(25)14(9-21-24)13-4-3-5-18-8-13/h3-10,21H,1-2H3
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Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)


BindingDB Entry DOI: 10.7270/Q2TB15J4
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118345
PNG
(US8653111, 113)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCSCC1)-n1ccnn1
Show InChI InChI=1S/C13H14N8OS/c22-13-10(20-2-1-16-18-20)8-17-21(13)12-7-11(14-9-15-12)19-3-5-23-6-4-19/h1-2,7-9,17H,3-6H2
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Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118330
PNG
(US8653111, 12)
Show SMILES OCc1ccc(nc1)-n1[nH]cc(-n2cnc(c2)C(F)(F)F)c1=O
Show InChI InChI=1S/C13H10F3N5O2/c14-13(15,16)10-5-20(7-18-10)9-4-19-21(12(9)23)11-2-1-8(6-22)3-17-11/h1-5,7,19,22H,6H2
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Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171823
PNG
(US9085572, 26)
Show SMILES Cc1ncccc1-c1c[nH]n(-c2ccccn2)c1=O
Show InChI InChI=1S/C14H12N4O/c1-10-11(5-4-8-15-10)12-9-17-18(14(12)19)13-6-2-3-7-16-13/h2-9,17H,1H3
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Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)


BindingDB Entry DOI: 10.7270/Q2H70DMQ
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118333
PNG
(US8653111, 45)
Show SMILES CC(C)c1cn(nn1)-c1c[nH]n(-c2ccc(CO)cn2)c1=O
Show InChI InChI=1S/C14H16N6O2/c1-9(2)11-7-19(18-17-11)12-6-16-20(14(12)22)13-4-3-10(8-21)5-15-13/h3-7,9,16,21H,8H2,1-2H3
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Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171822
PNG
(US9085572, 23)
Show SMILES OCc1ccc(nc1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C14H12N4O2/c19-9-10-3-4-13(16-6-10)18-14(20)12(8-17-18)11-2-1-5-15-7-11/h1-8,17,19H,9H2
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Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)


BindingDB Entry DOI: 10.7270/Q2H70DMQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3591
PNG
(US8524699, 7)
Show SMILES Clc1ccc(cc1)-c1nnc(s1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C16H10ClN5OS/c17-12-5-3-10(4-6-12)14-20-21-16(24-14)22-15(23)13(9-19-22)11-2-1-7-18-8-11/h1-9,19H
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Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)


BindingDB Entry DOI: 10.7270/Q2TB15J4
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3623
PNG
(US8524699, 28)
Show SMILES COCCN1CCN(CC1)c1cc(ncn1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C19H23N7O2/c1-28-10-9-24-5-7-25(8-6-24)17-11-18(22-14-21-17)26-19(27)16(13-23-26)15-3-2-4-20-12-15/h2-4,11-14,23H,5-10H2,1H3
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n/an/a 890n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)


BindingDB Entry DOI: 10.7270/Q2TB15J4
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM109271
PNG
(US8609698, 65)
Show SMILES Clc1cccc(Cl)c1NC(=O)NCc1ccnc(c1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C21H16Cl2N6O2/c22-16-4-1-5-17(23)19(16)28-21(31)26-10-13-6-8-25-18(9-13)29-20(30)15(12-27-29)14-3-2-7-24-11-14/h1-9,11-12,27H,10H2,(H2,26,28,31)
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n/an/a 900n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...


US Patent US8609698 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NZ8
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM109269
PNG
(US8609698, 18)
Show SMILES CC(C)(C)NC(=O)c1ccc(nc1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C18H19N5O2/c1-18(2,3)22-16(24)13-6-7-15(20-10-13)23-17(25)14(11-21-23)12-5-4-8-19-9-12/h4-11,21H,1-3H3,(H,22,24)
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n/an/a 910n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...


US Patent US8609698 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NZ8
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3629
PNG
(US8524699, 46)
Show SMILES O=c1c(c[nH]n1-c1cnccn1)-c1cccnc1
Show InChI InChI=1S/C12H9N5O/c18-12-10(9-2-1-3-13-6-9)7-16-17(12)11-8-14-4-5-15-11/h1-8,16H
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n/an/a 930n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)


BindingDB Entry DOI: 10.7270/Q2TB15J4
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50324535
PNG
(3-{[9-(Dimethylamino)nonanoyl](hydroxy)amino}propa...)
Show SMILES CN(C)CCCCCCCCC(=O)N(O)CCC(O)=O
Show InChI InChI=1S/C14H28N2O4/c1-15(2)11-8-6-4-3-5-7-9-13(17)16(20)12-10-14(18)19/h20H,3-12H2,1-2H3,(H,18,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay


J Med Chem 53: 5629-38 (2010)


Article DOI: 10.1021/jm1003655
BindingDB Entry DOI: 10.7270/Q2N87B02
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118337
PNG
(US8653111, 61)
Show SMILES Cc1cc(ncc1Br)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C11H9BrN6O/c1-7-4-10(13-5-8(7)12)18-11(19)9(6-15-18)17-3-2-14-16-17/h2-6,15H,1H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3643
PNG
(US8524699, 44)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCCC1)-c1cncc(c1)C#N
Show InChI InChI=1S/C18H17N7O/c19-8-13-6-14(10-20-9-13)15-11-23-25(18(15)26)17-7-16(21-12-22-17)24-4-2-1-3-5-24/h6-7,9-12,23H,1-5H2
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n/an/a 1.12E+3n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)


BindingDB Entry DOI: 10.7270/Q2TB15J4
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50324529
PNG
(3-({9-[Benzyl(methyl)]amino}nonanoyl(hydroxy)amino...)
Show SMILES CN(CCCCCCCCC(=O)N(O)CCC(O)=O)Cc1ccccc1
Show InChI InChI=1S/C20H32N2O4/c1-21(17-18-11-7-6-8-12-18)15-10-5-3-2-4-9-13-19(23)22(26)16-14-20(24)25/h6-8,11-12,26H,2-5,9-10,13-17H2,1H3,(H,24,25)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay


J Med Chem 53: 5629-38 (2010)


Article DOI: 10.1021/jm1003655
BindingDB Entry DOI: 10.7270/Q2N87B02
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118336
PNG
(US8653111, 60)
Show SMILES CCc1cc(ncn1)-n1[nH]cc(-n2cnc(c2)C(F)(F)F)c1=O
Show InChI InChI=1S/C13H11F3N6O/c1-2-8-3-11(18-6-17-8)22-12(23)9(4-20-22)21-5-10(19-7-21)13(14,15)16/h3-7,20H,2H2,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118334
PNG
(US8653111, 50)
Show SMILES Cc1cc(on1)-c1c[nH]n(-c2ccccn2)c1=O
Show InChI InChI=1S/C12H10N4O2/c1-8-6-10(18-15-8)9-7-14-16(12(9)17)11-4-2-3-5-13-11/h2-7,14H,1H3
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Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171826
PNG
(US9085572, 43)
Show SMILES OCc1ccnc(c1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C14H12N4O2/c19-9-10-3-5-16-13(6-10)18-14(20)12(8-17-18)11-2-1-4-15-7-11/h1-8,17,19H,9H2
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Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)


BindingDB Entry DOI: 10.7270/Q2H70DMQ
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50324534
PNG
(3-{[8-(Dimethylamino)octanoyl](hydroxy)amino}propa...)
Show SMILES CN(C)CCCCCCCC(=O)N(O)CCC(O)=O
Show InChI InChI=1S/C13H26N2O4/c1-14(2)10-7-5-3-4-6-8-12(16)15(19)11-9-13(17)18/h19H,3-11H2,1-2H3,(H,17,18)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay


J Med Chem 53: 5629-38 (2010)


Article DOI: 10.1021/jm1003655
BindingDB Entry DOI: 10.7270/Q2N87B02
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM26113
PNG
(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Show SMILES OC(=O)c1ccnc(c1)C(O)=O
Show InChI InChI=1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PHD1 expressed in Sf9 cells by time-resolved fluorescence assay


J Med Chem 53: 5629-38 (2010)


Article DOI: 10.1021/jm1003655
BindingDB Entry DOI: 10.7270/Q2N87B02
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50324536
PNG
(3-{[10-(Dimethylamino)decanoyl](hydroxy)amino}prop...)
Show SMILES CN(C)CCCCCCCCCC(=O)N(O)CCC(O)=O
Show InChI InChI=1S/C15H30N2O4/c1-16(2)12-9-7-5-3-4-6-8-10-14(18)17(21)13-11-15(19)20/h21H,3-13H2,1-2H3,(H,19,20)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay


J Med Chem 53: 5629-38 (2010)


Article DOI: 10.1021/jm1003655
BindingDB Entry DOI: 10.7270/Q2N87B02
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM109272
PNG
(US8609698, 80)
Show SMILES Cc1ccccc1NC(=O)OCc1ccc(nc1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C22H19N5O3/c1-15-5-2-3-7-19(15)26-22(29)30-14-16-8-9-20(24-11-16)27-21(28)18(13-25-27)17-6-4-10-23-12-17/h2-13,25H,14H2,1H3,(H,26,29)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...


US Patent US8609698 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NZ8
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50324530
PNG
(CHEMBL1215590 | tert-Butyl 3-({Hydroxy[9-(methylam...)
Show SMILES CNCCCCCCCCC(=O)N(O)CCC(O)=O
Show InChI InChI=1S/C13H26N2O4/c1-14-10-7-5-3-2-4-6-8-12(16)15(19)11-9-13(17)18/h14,19H,2-11H2,1H3,(H,17,18)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay


J Med Chem 53: 5629-38 (2010)


Article DOI: 10.1021/jm1003655
BindingDB Entry DOI: 10.7270/Q2N87B02
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118343
PNG
(US8653111, 101)
Show SMILES OC1CN(C1)c1cc(ncn1)-n1[nH]cc(-n2ccnc2)c1=O
Show InChI InChI=1S/C13H13N7O2/c21-9-5-19(6-9)11-3-12(16-7-15-11)20-13(22)10(4-17-20)18-2-1-14-8-18/h1-4,7-9,17,21H,5-6H2
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n/an/a 1.70E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM3644
PNG
(US8524699, 55)
Show SMILES CCN(CC)CCCCCCNc1cc(ncn1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C22H31N7O/c1-3-28(4-2)13-8-6-5-7-12-24-20-14-21(26-17-25-20)29-22(30)19(16-27-29)18-10-9-11-23-15-18/h9-11,14-17,27H,3-8,12-13H2,1-2H3,(H,24,25,26)
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Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.


US Patent US8524699 (2013)


BindingDB Entry DOI: 10.7270/Q2TB15J4
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118332
PNG
(US8653111, 43)
Show SMILES Cc1cn(nn1)-c1c[nH]n(-c2cnccn2)c1=O
Show InChI InChI=1S/C10H9N7O/c1-7-6-16(15-14-7)8-4-13-17(10(8)18)9-5-11-2-3-12-9/h2-6,13H,1H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118340
PNG
(US8653111, 83)
Show SMILES FC(F)(F)c1ccnc(c1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C11H7F3N6O/c12-11(13,14)7-1-2-15-9(5-7)20-10(21)8(6-17-20)19-4-3-16-18-19/h1-6,17H
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n/an/a 1.90E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171829
PNG
(US9085572, 48)
Show SMILES O=C(NCc1ccnc(c1)-n1[nH]cc(-c2cccnc2)c1=O)c1ccccc1
Show InChI InChI=1S/C21H17N5O2/c27-20(16-5-2-1-3-6-16)24-12-15-8-10-23-19(11-15)26-21(28)18(14-25-26)17-7-4-9-22-13-17/h1-11,13-14,25H,12H2,(H,24,27)
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Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)


BindingDB Entry DOI: 10.7270/Q2H70DMQ
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171830
PNG
(US9085572, 50)
Show SMILES Clc1cnn(CCC(=O)NCc2ccnc(c2)-n2[nH]cc(-c3cccnc3)c2=O)c1
Show InChI InChI=1S/C20H18ClN7O2/c21-16-11-25-27(13-16)7-4-19(29)24-9-14-3-6-23-18(8-14)28-20(30)17(12-26-28)15-2-1-5-22-10-15/h1-3,5-6,8,10-13,26H,4,7,9H2,(H,24,29)
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Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)


BindingDB Entry DOI: 10.7270/Q2H70DMQ
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM118335
PNG
(US8653111, 55)
Show SMILES Cc1cn(cn1)-c1c[nH]n(-c2ccccn2)c1=O
Show InChI InChI=1S/C12H11N5O/c1-9-7-16(8-14-9)10-6-15-17(12(10)18)11-4-2-3-5-13-11/h2-8,15H,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50324529
PNG
(3-({9-[Benzyl(methyl)]amino}nonanoyl(hydroxy)amino...)
Show SMILES CN(CCCCCCCCC(=O)N(O)CCC(O)=O)Cc1ccccc1
Show InChI InChI=1S/C20H32N2O4/c1-21(17-18-11-7-6-8-12-18)15-10-5-3-2-4-9-13-19(23)22(26)16-14-20(24)25/h6-8,11-12,26H,2-5,9-10,13-17H2,1H3,(H,24,25)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged JMJD2A expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay


J Med Chem 53: 5629-38 (2010)


Article DOI: 10.1021/jm1003655
BindingDB Entry DOI: 10.7270/Q2N87B02
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50324527
PNG
(4-[(8-Dimethylaminooctyl)-(hydroxyl)amino]-4-oxobu...)
Show SMILES CN(C)CCCCCCCCN(O)C(=O)CCC(O)=O
Show InChI InChI=1S/C14H28N2O4/c1-15(2)11-7-5-3-4-6-8-12-16(20)13(17)9-10-14(18)19/h20H,3-12H2,1-2H3,(H,18,19)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay


J Med Chem 53: 5629-38 (2010)


Article DOI: 10.1021/jm1003655
BindingDB Entry DOI: 10.7270/Q2N87B02
More data for this
Ligand-Target Pair
Egl nine homolog 2


(Homo sapiens (Human))
BDBM26106
PNG
(CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylg...)
Show SMILES OC(=O)CNC(=O)C(O)=O
Show InChI InChI=1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PHD1 expressed in Sf9 cells by time-resolved fluorescence assay


J Med Chem 53: 5629-38 (2010)


Article DOI: 10.1021/jm1003655
BindingDB Entry DOI: 10.7270/Q2N87B02
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171828
PNG
(US9085572, 47)
Show SMILES CC(=O)NCc1ccnc(c1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C16H15N5O2/c1-11(22)19-8-12-4-6-18-15(7-12)21-16(23)14(10-20-21)13-3-2-5-17-9-13/h2-7,9-10,20H,8H2,1H3,(H,19,22)
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n/an/a 2.20E+3n/an/an/an/a7.5n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)


BindingDB Entry DOI: 10.7270/Q2H70DMQ
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171825
PNG
(US9085572, 35)
Show SMILES NCc1ccnc(c1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C14H13N5O/c15-7-10-3-5-17-13(6-10)19-14(20)12(9-18-19)11-2-1-4-16-8-11/h1-6,8-9,18H,7,15H2
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n/an/a 2.30E+3n/an/an/an/a7.5n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)


BindingDB Entry DOI: 10.7270/Q2H70DMQ
More data for this
Ligand-Target Pair
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