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Compile Data Set for Download or QSAR

Found 688 hits with Last Name = 'ohkubo' and Initial = 'm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50099066
PNG
(CHEMBL279115 | phorbol 13-acetate 12-myristate)
Show SMILES CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(C)=O |r,c:33,t:22|
Show InChI InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30?,32-,34-,35-,36-/m1/s1
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6.40n/an/an/an/an/an/an/an/a



RIKEN Advanced Science Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from human recombinant PKCalpha after 20 mins by liquid scintillation counting


Bioorg Med Chem Lett 21: 3587-90 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.108
BindingDB Entry DOI: 10.7270/Q2HM58TF
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50345024
PNG
((R)-(4-(dodecyloxy)-1-(hydroxymethyl)-3-oxo-1,3-di...)
Show SMILES CCCCCCCCCCCCOc1cccc2c1C(=O)O[C@]2(CO)COC(=O)C(C(C)(C)C)C(C)(C)C |r|
Show InChI InChI=1S/C32H52O6/c1-8-9-10-11-12-13-14-15-16-17-21-36-25-20-18-19-24-26(25)28(34)38-32(24,22-33)23-37-29(35)27(30(2,3)4)31(5,6)7/h18-20,27,33H,8-17,21-23H2,1-7H3/t32-/m1/s1
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43n/an/an/an/an/an/an/an/a



RIKEN Advanced Science Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from human recombinant PKCalpha after 20 mins by liquid scintillation counting


Bioorg Med Chem Lett 21: 3587-90 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.108
BindingDB Entry DOI: 10.7270/Q2HM58TF
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50345027
PNG
(((R)-4-(3-((2R,3R,5S,6S)-4-(dodecyloxy)-2,3,5,6-te...)
Show SMILES CCCCCCCCCCCCO[C@H]1[C@@H](OC)[C@H](OC)[C@@H](OCC#Cc2cccc3c2C(=O)O[C@]3(CO)COC(=O)C(C(C)(C)C)C(C)(C)C)[C@H](OC)[C@H]1OC |r|
Show InChI InChI=1S/C45H72O11/c1-12-13-14-15-16-17-18-19-20-21-27-53-38-34(49-8)36(51-10)39(37(52-11)35(38)50-9)54-28-23-25-31-24-22-26-32-33(31)41(47)56-45(32,29-46)30-55-42(48)40(43(2,3)4)44(5,6)7/h22,24,26,34-40,46H,12-21,27-30H2,1-11H3/t34-,35+,36-,37+,38-,39+,45-/m1/s1
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600n/an/an/an/an/an/an/an/a



RIKEN Advanced Science Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from human recombinant PKCalpha after 20 mins by liquid scintillation counting


Bioorg Med Chem Lett 21: 3587-90 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.108
BindingDB Entry DOI: 10.7270/Q2HM58TF
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50345026
PNG
((1R,2R,4S,5S)-3-(3-((R)-1-((2-tert-butyl-3,3-dimet...)
Show SMILES CCCCCCCCCCCCO[C@@H]1[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OCC#Cc2cccc3c2C(=O)O[C@]3(CO)COC(=O)C(C(C)(C)C)C(C)(C)C)[C@@H](OC(C)=O)[C@@H]1OC(C)=O |r|
Show InChI InChI=1S/C49H72O15/c1-12-13-14-15-16-17-18-19-20-21-27-57-38-40(60-31(2)51)42(62-33(4)53)39(43(63-34(5)54)41(38)61-32(3)52)58-28-23-25-35-24-22-26-36-37(35)45(55)64-49(36,29-50)30-59-46(56)44(47(6,7)8)48(9,10)11/h22,24,26,38-44,50H,12-21,27-30H2,1-11H3/t38-,39+,40+,41-,42+,43-,49-/m1/s1
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2.34E+3n/an/an/an/an/an/an/an/a



RIKEN Advanced Science Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from human recombinant PKCalpha after 20 mins by liquid scintillation counting


Bioorg Med Chem Lett 21: 3587-90 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.108
BindingDB Entry DOI: 10.7270/Q2HM58TF
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50345025
PNG
((R)-(4-(dodecyloxy)-1-(hydroxymethyl)-3-oxo-1,3-di...)
Show SMILES CCCCCCCCCCCCOc1cccc2c1C(=O)O[C@]2(CO)COC(=O)CCCCCCCCCCC |r|
Show InChI InChI=1S/C34H56O6/c1-3-5-7-9-11-13-15-17-19-21-26-38-30-24-22-23-29-32(30)33(37)40-34(29,27-35)28-39-31(36)25-20-18-16-14-12-10-8-6-4-2/h22-24,35H,3-21,25-28H2,1-2H3/t34-/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



RIKEN Advanced Science Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from human recombinant PKCalpha after 20 mins by liquid scintillation counting


Bioorg Med Chem Lett 21: 3587-90 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.108
BindingDB Entry DOI: 10.7270/Q2HM58TF
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50345028
PNG
(((R)-4-(3-((1S,2S,3R,4R,5S,6R)-4-(dodecyloxy)-2,3,...)
Show SMILES [#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#8]-[#6@@H]-1-[#6@H](-[#8]-[#6]\[#6]=[#6](\[#6])-[#6])-[#6@@H](-[#8]-[#6]\[#6]=[#6]\[#6](-[#6])-[#6])-[#6@H](-[#8]-[#6]C#Cc2cccc3c2-[#6](=O)-[#8][C@]3([#6]-[#8])[#6]-[#8]-[#6](=O)-[#6](C([#6])([#6])[#6])C([#6])([#6])[#6])-[#6@@H](-[#8]-[#6]\[#6]=[#6](\[#6])-[#6])-[#6@@H]-1-[#8]-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C62H98O11/c1-16-17-18-19-20-21-22-23-24-25-36-66-53-54(69-39-33-45(4)5)51(67-37-27-29-44(2)3)52(55(70-40-34-46(6)7)56(53)71-41-35-47(8)9)68-38-28-31-48-30-26-32-49-50(48)58(64)73-62(49,42-63)43-72-59(65)57(60(10,11)12)61(13,14)15/h26-27,29-30,32-35,44,51-57,63H,16-25,36-43H2,1-15H3/b29-27+/t51-,52-,53+,54+,55+,56+,62+/m0/s1
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>2.00E+4n/an/an/an/an/an/an/an/a



RIKEN Advanced Science Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from human recombinant PKCalpha after 20 mins by liquid scintillation counting


Bioorg Med Chem Lett 21: 3587-90 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.108
BindingDB Entry DOI: 10.7270/Q2HM58TF
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50345029
PNG
(((R)-1-(hydroxymethyl)-3-oxo-4-(3-((2R,3S,5R,6S)-2...)
Show SMILES CCCCCCCCCCCCO[C@@H]1[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCC#Cc2cccc3c2C(=O)O[C@]3(CO)COC(=O)C(C(C)(C)C)C(C)(C)C)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 |r|
Show InChI InChI=1S/C69H88O11/c1-8-9-10-11-12-13-14-15-16-29-43-73-58-60(75-45-51-32-21-17-22-33-51)62(77-47-53-36-25-19-26-37-53)59(63(78-48-54-38-27-20-28-39-54)61(58)76-46-52-34-23-18-24-35-52)74-44-31-41-55-40-30-42-56-57(55)65(71)80-69(56,49-70)50-79-66(72)64(67(2,3)4)68(5,6)7/h17-28,30,32-40,42,58-64,70H,8-16,29,43-50H2,1-7H3/t58-,59+,60+,61-,62+,63-,69-/m1/s1
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>2.00E+4n/an/an/an/an/an/an/an/a



RIKEN Advanced Science Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from human recombinant PKCalpha after 20 mins by liquid scintillation counting


Bioorg Med Chem Lett 21: 3587-90 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.108
BindingDB Entry DOI: 10.7270/Q2HM58TF
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50345030
PNG
(((R)-4-(3-((2R,3S,5R,6S)-4-(dodecyloxy)-2,3,5,6-te...)
Show SMILES CCCCCCCCCCCCO[C@@H]1[C@H](OCc2ccc(cc2)C(C)C)[C@@H](OCc2ccc(cc2)C(C)C)[C@H](OCC#Cc2cccc3c2C(=O)O[C@]3(CO)COC(=O)C(C(C)(C)C)C(C)(C)C)[C@@H](OCc2ccc(cc2)C(C)C)[C@@H]1OCc1ccc(cc1)C(C)C |r|
Show InChI InChI=1S/C81H112O11/c1-16-17-18-19-20-21-22-23-24-25-47-85-70-72(87-49-59-31-39-63(40-32-59)55(2)3)74(89-51-61-35-43-65(44-36-61)57(6)7)71(75(90-52-62-37-45-66(46-38-62)58(8)9)73(70)88-50-60-33-41-64(42-34-60)56(4)5)86-48-27-29-67-28-26-30-68-69(67)77(83)92-81(68,53-82)54-91-78(84)76(79(10,11)12)80(13,14)15/h26,28,30-46,55-58,70-76,82H,16-25,47-54H2,1-15H3/t70-,71+,72+,73-,74+,75-,81-/m1/s1
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>2.00E+4n/an/an/an/an/an/an/an/a



RIKEN Advanced Science Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from human recombinant PKCalpha after 20 mins by liquid scintillation counting


Bioorg Med Chem Lett 21: 3587-90 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.108
BindingDB Entry DOI: 10.7270/Q2HM58TF
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50345031
PNG
(((R)-4-(3-((2R,3S,5R,6S)-4-(dodecyloxy)-2,3,5,6-te...)
Show SMILES CCCCCCCCCCCCO[C@@H]1[C@H](OCc2ccc(F)cc2)[C@@H](OCc2ccc(F)cc2)[C@H](OCC#Cc2cccc3c2C(=O)O[C@]3(CO)COC(=O)C(C(C)(C)C)C(C)(C)C)[C@@H](OCc2ccc(F)cc2)[C@@H]1OCc1ccc(F)cc1 |r|
Show InChI InChI=1S/C69H84F4O11/c1-8-9-10-11-12-13-14-15-16-17-39-77-58-60(79-41-47-23-31-52(70)32-24-47)62(81-43-49-27-35-54(72)36-28-49)59(63(82-44-50-29-37-55(73)38-30-50)61(58)80-42-48-25-33-53(71)34-26-48)78-40-19-21-51-20-18-22-56-57(51)65(75)84-69(56,45-74)46-83-66(76)64(67(2,3)4)68(5,6)7/h18,20,22-38,58-64,74H,8-17,39-46H2,1-7H3/t58-,59+,60+,61-,62+,63-,69-/m1/s1
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>2.00E+4n/an/an/an/an/an/an/an/a



RIKEN Advanced Science Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from human recombinant PKCalpha after 20 mins by liquid scintillation counting


Bioorg Med Chem Lett 21: 3587-90 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.108
BindingDB Entry DOI: 10.7270/Q2HM58TF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126609
PNG
(US8772283, 53)
Show InChI InChI=1S/C28H26N4O3/c1-27(34)14-28(30,15-27)20-10-7-17(8-11-20)23-24(18-5-3-2-4-6-18)32-16-35-22-12-9-19(25(29)33)13-21(22)26(32)31-23/h2-13,34H,14-16,30H2,1H3,(H2,29,33)
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US Patent
n/an/a 0.260n/an/an/an/a7.5n/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126581
PNG
(US8772283, 25)
Show SMILES COc1cc(OC)c2-c3nc(c(-c4ccccc4)n3COc2c1)-c1ccc(cc1)C1(N)CC(O)(C1)C1CC1 |(-8.4,-.89,;-7.63,.45,;-6.09,.45,;-5.32,1.78,;-3.78,1.78,;-2.69,2.87,;-3.09,4.36,;-3.01,.45,;-1.47,.45,;-.5,1.64,;.93,1.09,;.85,-.45,;2.06,-1.41,;1.66,-2.89,;2.75,-3.98,;4.23,-3.58,;4.63,-2.1,;3.54,-1.01,;-.7,-.89,;-1.47,-2.22,;-3.01,-2.22,;-3.78,-.89,;-5.32,-.89,;2.23,1.93,;2.23,3.47,;3.56,4.24,;4.89,3.47,;4.89,1.93,;3.56,1.16,;6.23,4.24,;7.56,3.47,;5.14,5.33,;6.31,6.43,;6.36,7.97,;7.32,5.33,;4.9,7.07,;3.57,6.3,;4.13,8.4,)|
Show InChI InChI=1S/C31H31N3O4/c1-36-23-14-24(37-2)26-25(15-23)38-18-34-28(20-6-4-3-5-7-20)27(33-29(26)34)19-8-10-21(11-9-19)30(32)16-31(35,17-30)22-12-13-22/h3-11,14-15,22,35H,12-13,16-18,32H2,1-2H3
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n/an/a 0.270n/an/an/an/a7.5n/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126608
PNG
(US8772283, 52)
Show InChI InChI=1S/C29H28N4O3/c1-28(35)15-29(30,16-28)21-11-8-18(9-12-21)24-25(19-6-4-3-5-7-19)33-17-36-23-13-10-20(27(34)31-2)14-22(23)26(33)32-24/h3-14,35H,15-17,30H2,1-2H3,(H,31,34)
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n/an/a 0.280n/an/an/an/a7.5n/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126557
PNG
(US8772283, 1)
Show SMILES NC1(CC(O)(C1)C1CC1)c1ccc(cc1)-c1nc2-c3c(F)cccc3OCn2c1-c1ccccc1 |(7.56,3.47,;6.23,4.24,;5.14,5.33,;6.31,6.43,;6.36,7.97,;7.32,5.33,;4.9,7.07,;3.57,6.3,;4.13,8.4,;4.89,3.47,;3.56,4.24,;2.23,3.47,;2.23,1.93,;3.56,1.16,;4.89,1.93,;.93,1.09,;-.5,1.64,;-1.47,.45,;-3.01,.45,;-3.78,1.78,;-2.69,2.87,;-5.32,1.78,;-6.09,.45,;-5.32,-.89,;-3.78,-.89,;-3.01,-2.22,;-1.47,-2.22,;-.7,-.89,;.85,-.45,;2.06,-1.41,;1.66,-2.89,;2.75,-3.98,;4.23,-3.58,;4.63,-2.1,;3.54,-1.01,)|
Show InChI InChI=1S/C29H26FN3O2/c30-22-7-4-8-23-24(22)27-32-25(26(33(27)17-35-23)19-5-2-1-3-6-19)18-9-11-20(12-10-18)28(31)15-29(34,16-28)21-13-14-21/h1-12,21,34H,13-17,31H2
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n/an/a 0.290n/an/an/an/a7.5n/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126578
PNG
(US8772283, 22)
Show SMILES NC1(CC(O)(C1)C1CC1)c1ccc(cc1)-c1nc2-c3c(Cl)cccc3OCn2c1-c1ccccc1 |(7.56,3.47,;6.23,4.24,;5.14,5.33,;6.31,6.43,;6.36,7.97,;7.32,5.33,;4.9,7.07,;3.57,6.3,;4.13,8.4,;4.89,3.47,;3.56,4.24,;2.23,3.47,;2.23,1.93,;3.56,1.16,;4.89,1.93,;.93,1.09,;-.5,1.64,;-1.47,.45,;-3.01,.45,;-3.78,1.78,;-2.69,2.87,;-5.32,1.78,;-6.09,.45,;-5.32,-.89,;-3.78,-.89,;-3.01,-2.22,;-1.47,-2.22,;-.7,-.89,;.85,-.45,;2.06,-1.41,;1.66,-2.89,;2.75,-3.98,;4.23,-3.58,;4.63,-2.1,;3.54,-1.01,)|
Show InChI InChI=1S/C29H26ClN3O2/c30-22-7-4-8-23-24(22)27-32-25(26(33(27)17-35-23)19-5-2-1-3-6-19)18-9-11-20(12-10-18)28(31)15-29(34,16-28)21-13-14-21/h1-12,21,34H,13-17,31H2
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126611
PNG
(US8772283, 55)
Show InChI InChI=1S/C30H30N4O3/c1-3-32-28(35)21-11-14-24-23(15-21)27-33-25(26(34(27)18-37-24)20-7-5-4-6-8-20)19-9-12-22(13-10-19)30(31)16-29(2,36)17-30/h4-15,36H,3,16-18,31H2,1-2H3,(H,32,35)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126604
PNG
(US8772283, 48)
Show InChI InChI=1S/C30H27N5O2/c1-29(36)16-30(31,17-29)22-10-7-19(8-11-22)26-27(20-5-3-2-4-6-20)35-18-37-25-12-9-21(24-13-14-32-34-24)15-23(25)28(35)33-26/h2-15,36H,16-18,31H2,1H3,(H,32,34)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126572
PNG
(US8772283, 16)
Show SMILES COc1cccc2OCn3c(nc(c3-c3ccccc3)-c3ccc(cc3)C3(N)CC(O)(C3)C3CC3)-c12 |(-3.09,4.36,;-2.69,2.87,;-3.78,1.78,;-5.32,1.78,;-6.09,.45,;-5.32,-.89,;-3.78,-.89,;-3.01,-2.22,;-1.47,-2.22,;-.7,-.89,;-1.47,.45,;-.5,1.64,;.93,1.09,;.85,-.45,;2.06,-1.41,;1.66,-2.89,;2.75,-3.98,;4.23,-3.58,;4.63,-2.1,;3.54,-1.01,;2.23,1.93,;2.23,3.47,;3.56,4.24,;4.89,3.47,;4.89,1.93,;3.56,1.16,;6.23,4.24,;7.56,3.47,;5.14,5.33,;6.31,6.43,;6.36,7.97,;7.32,5.33,;4.9,7.07,;3.57,6.3,;4.13,8.4,;-3.01,.45,)|
Show InChI InChI=1S/C30H29N3O3/c1-35-23-8-5-9-24-25(23)28-32-26(27(33(28)18-36-24)20-6-3-2-4-7-20)19-10-12-21(13-11-19)29(31)16-30(34,17-29)22-14-15-22/h2-13,22,34H,14-18,31H2,1H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126618
PNG
(US8772283, 62)
Show InChI InChI=1S/C28H26N4O3/c1-27(34)14-28(30,15-27)20-10-7-17(8-11-20)23-24(18-5-3-2-4-6-18)32-16-35-22-13-19(25(29)33)9-12-21(22)26(32)31-23/h2-13,34H,14-16,30H2,1H3,(H2,29,33)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126617
PNG
(US8772283, 61)
Show InChI InChI=1S/C30H30N4O4/c1-3-38-33-28(35)21-11-14-24-23(15-21)27-32-25(26(34(27)18-37-24)20-7-5-4-6-8-20)19-9-12-22(13-10-19)30(31)16-29(2,36)17-30/h4-15,36H,3,16-18,31H2,1-2H3,(H,33,35)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126605
PNG
(US8772283, 49)
Show InChI InChI=1S/C30H27N5O2/c1-29(36)16-30(31,17-29)23-10-7-19(8-11-23)26-27(20-5-3-2-4-6-20)35-18-37-25-12-9-21(22-14-32-33-15-22)13-24(25)28(35)34-26/h2-15,36H,16-18,31H2,1H3,(H,32,33)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126591
PNG
(US8772283, 35)
Show SMILES NC1(CC(O)(C1)C1CC1)c1ccc(cc1)-c1nc2-c3ccncc3OCn2c1-c1ccccc1 |(7.56,3.47,;6.23,4.24,;5.14,5.33,;6.31,6.43,;6.36,7.97,;7.32,5.33,;4.9,7.07,;3.57,6.3,;4.13,8.4,;4.89,3.47,;3.56,4.24,;2.23,3.47,;2.23,1.93,;3.56,1.16,;4.89,1.93,;.93,1.09,;-.5,1.64,;-1.47,.45,;-3.01,.45,;-3.78,1.78,;-5.32,1.78,;-6.09,.45,;-5.32,-.89,;-3.78,-.89,;-3.01,-2.22,;-1.47,-2.22,;-.7,-.89,;.85,-.45,;2.06,-1.41,;1.66,-2.89,;2.75,-3.98,;4.23,-3.58,;4.63,-2.1,;3.54,-1.01,)|
Show InChI InChI=1S/C28H26N4O2/c29-27(15-28(33,16-27)21-10-11-21)20-8-6-18(7-9-20)24-25(19-4-2-1-3-5-19)32-17-34-23-14-30-13-12-22(23)26(32)31-24/h1-9,12-14,21,33H,10-11,15-17,29H2
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126612
PNG
(US8772283, 56)
Show InChI InChI=1S/C29H28N4O3/c1-28(35)15-29(30,16-28)21-11-8-18(9-12-21)24-25(19-6-4-3-5-7-19)33-17-36-23-14-20(27(34)31-2)10-13-22(23)26(33)32-24/h3-14,35H,15-17,30H2,1-2H3,(H,31,34)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126558
PNG
(US8772283, 2)
Show InChI InChI=1S/C27H24FN3O2/c1-26(32)14-27(29,15-26)19-12-10-17(11-13-19)23-24(18-6-3-2-4-7-18)31-16-33-21-9-5-8-20(28)22(21)25(31)30-23/h2-13,32H,14-16,29H2,1H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126615
PNG
(US8772283, 59)
Show InChI InChI=1S/C30H30N4O4/c1-3-38-33-28(35)21-11-14-23-24(15-21)37-18-34-26(20-7-5-4-6-8-20)25(32-27(23)34)19-9-12-22(13-10-19)30(31)16-29(2,36)17-30/h4-15,36H,3,16-18,31H2,1-2H3,(H,33,35)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126600
PNG
(US8772283, 44)
Show InChI InChI=1S/C28H27N3O3/c1-27(33)15-28(29,16-27)21-10-8-19(9-11-21)24-25(20-5-3-2-4-6-20)31-17-34-23-12-7-18(14-32)13-22(23)26(31)30-24/h2-13,32-33H,14-17,29H2,1H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126616
PNG
(US8772283, 60)
Show InChI InChI=1S/C30H30N4O4/c1-29(37)16-30(31,17-29)22-10-7-19(8-11-22)25-26(20-5-3-2-4-6-20)34-18-38-24-12-9-21(28(36)32-13-14-35)15-23(24)27(34)33-25/h2-12,15,35,37H,13-14,16-18,31H2,1H3,(H,32,36)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126574
PNG
(US8772283, 18)
Show SMILES COc1ccc2-c3nc(c(-c4ccccc4)n3COc2c1)-c1ccc(cc1)C1(N)CC(O)(C1)C1CC1 |(-8.4,-.89,;-7.63,.45,;-6.09,.45,;-5.32,1.78,;-3.78,1.78,;-3.01,.45,;-1.47,.45,;-.5,1.64,;.93,1.09,;.85,-.45,;2.06,-1.41,;1.66,-2.89,;2.75,-3.98,;4.23,-3.58,;4.63,-2.1,;3.54,-1.01,;-.7,-.89,;-1.47,-2.22,;-3.01,-2.22,;-3.78,-.89,;-5.32,-.89,;2.23,1.93,;2.23,3.47,;3.56,4.24,;4.89,3.47,;4.89,1.93,;3.56,1.16,;6.23,4.24,;7.56,3.47,;5.14,5.33,;6.31,6.43,;6.36,7.97,;7.32,5.33,;4.9,7.07,;3.57,6.3,;4.13,8.4,)|
Show InChI InChI=1S/C30H29N3O3/c1-35-23-13-14-24-25(15-23)36-18-33-27(20-5-3-2-4-6-20)26(32-28(24)33)19-7-9-21(10-8-19)29(31)16-30(34,17-29)22-11-12-22/h2-10,13-15,22,34H,11-12,16-18,31H2,1H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126614
PNG
(US8772283, 58)
Show InChI InChI=1S/C30H30N4O4/c1-29(37)16-30(31,17-29)22-10-7-19(8-11-22)25-26(20-5-3-2-4-6-20)34-18-38-24-15-21(28(36)32-13-14-35)9-12-23(24)27(34)33-25/h2-12,15,35,37H,13-14,16-18,31H2,1H3,(H,32,36)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126560
PNG
(US8772283, 4)
Show SMILES NC1(CC(O)(C1)C1CC1)c1ccc(cc1)-c1nc2-c3c(F)cccc3OCn2c1-c1ccsc1 |(7.56,3.47,;6.23,4.24,;5.14,5.33,;6.31,6.43,;6.36,7.97,;7.32,5.33,;4.9,7.07,;3.57,6.3,;4.13,8.4,;4.89,3.47,;3.56,4.24,;2.23,3.47,;2.23,1.93,;3.56,1.16,;4.89,1.93,;.93,1.09,;-.5,1.64,;-1.47,.45,;-3.01,.45,;-3.78,1.78,;-2.69,2.87,;-5.32,1.78,;-6.09,.45,;-5.32,-.89,;-3.78,-.89,;-3.01,-2.22,;-1.47,-2.22,;-.7,-.89,;.85,-.45,;2.06,-1.41,;3.49,-.85,;4.46,-2.05,;3.62,-3.34,;2.14,-2.94,)|
Show InChI InChI=1S/C27H24FN3O2S/c28-20-2-1-3-21-22(20)25-30-23(24(31(25)15-33-21)17-10-11-34-12-17)16-4-6-18(7-5-16)26(29)13-27(32,14-26)19-8-9-19/h1-7,10-12,19,32H,8-9,13-15,29H2
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126592
PNG
(US8772283, 36)
Show InChI InChI=1S/C26H24N4O2/c1-25(31)14-26(27,15-25)19-9-7-17(8-10-19)22-23(18-5-3-2-4-6-18)30-16-32-21-13-28-12-11-20(21)24(30)29-22/h2-13,31H,14-16,27H2,1H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126576
PNG
(US8772283, 20)
Show InChI InChI=1S/C28H27N3O3/c1-27(32)15-28(29,16-27)20-10-8-18(9-11-20)24-25(19-6-4-3-5-7-19)31-17-34-23-13-12-21(33-2)14-22(23)26(31)30-24/h3-14,32H,15-17,29H2,1-2H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126587
PNG
(US8772283, 31)
Show InChI InChI=1S/C27H26N4O2/c1-2-26(32)15-27(28,16-26)20-10-8-18(9-11-20)23-24(19-6-4-3-5-7-19)31-17-33-22-12-13-29-14-21(22)25(31)30-23/h3-14,32H,2,15-17,28H2,1H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM126604
PNG
(US8772283, 48)
Show InChI InChI=1S/C30H27N5O2/c1-29(36)16-30(31,17-29)22-10-7-19(8-11-22)26-27(20-5-3-2-4-6-20)35-18-37-25-12-9-21(24-13-14-32-34-24)15-23(25)28(35)33-26/h2-15,36H,16-18,31H2,1H3,(H,32,34)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126606
PNG
(US8772283, 50)
Show InChI InChI=1S/C27H26N4O2/c1-17-12-21-23(29-13-17)25-30-22(24(31(25)16-33-21)19-6-4-3-5-7-19)18-8-10-20(11-9-18)27(28)14-26(2,32)15-27/h3-13,32H,14-16,28H2,1-2H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126594
PNG
(US8772283, 38)
Show SMILES NC1(CC(O)(C1)C1CC1)c1ccc(cc1)-c1nc2-c3cccnc3OCn2c1-c1ccccc1 |(7.56,3.47,;6.23,4.24,;5.14,5.33,;6.31,6.43,;6.36,7.97,;7.32,5.33,;4.9,7.07,;3.57,6.3,;4.13,8.4,;4.89,3.47,;3.56,4.24,;2.23,3.47,;2.23,1.93,;3.56,1.16,;4.89,1.93,;.93,1.09,;-.5,1.64,;-1.47,.45,;-3.01,.45,;-3.78,1.78,;-5.32,1.78,;-6.09,.45,;-5.32,-.89,;-3.78,-.89,;-3.01,-2.22,;-1.47,-2.22,;-.7,-.89,;.85,-.45,;2.06,-1.41,;1.66,-2.89,;2.75,-3.98,;4.23,-3.58,;4.63,-2.1,;3.54,-1.01,)|
Show InChI InChI=1S/C28H26N4O2/c29-27(15-28(33,16-27)21-12-13-21)20-10-8-18(9-11-20)23-24(19-5-2-1-3-6-19)32-17-34-26-22(25(32)31-23)7-4-14-30-26/h1-11,14,21,33H,12-13,15-17,29H2
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126562
PNG
(US8772283, 6)
Show InChI InChI=1S/C25H22FN3O2S/c1-24(30)12-25(27,13-24)17-7-5-15(6-8-17)21-22(16-9-10-32-11-16)29-14-31-19-4-2-3-18(26)20(19)23(29)28-21/h2-11,30H,12-14,27H2,1H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126561
PNG
(US8772283, 5)
Show SMILES NC1(CC(O)(C1)C1CC1)c1ccc(cc1)-c1nc2-c3c(F)cccc3OCn2c1-c1ccncc1 |(7.56,3.47,;6.23,4.24,;5.14,5.33,;6.31,6.43,;6.36,7.97,;7.32,5.33,;4.9,7.07,;3.57,6.3,;4.13,8.4,;4.89,3.47,;3.56,4.24,;2.23,3.47,;2.23,1.93,;3.56,1.16,;4.89,1.93,;.93,1.09,;-.5,1.64,;-1.47,.45,;-3.01,.45,;-3.78,1.78,;-2.69,2.87,;-5.32,1.78,;-6.09,.45,;-5.32,-.89,;-3.78,-.89,;-3.01,-2.22,;-1.47,-2.22,;-.7,-.89,;.85,-.45,;2.06,-1.41,;1.66,-2.89,;2.75,-3.98,;4.23,-3.58,;4.63,-2.1,;3.54,-1.01,)|
Show InChI InChI=1S/C28H25FN4O2/c29-21-2-1-3-22-23(21)26-32-24(25(33(26)16-35-22)18-10-12-31-13-11-18)17-4-6-19(7-5-17)27(30)14-28(34,15-27)20-8-9-20/h1-7,10-13,20,34H,8-9,14-16,30H2
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126619
PNG
(US8772283, 63)
Show InChI InChI=1S/C28H24N2O5/c1-27(33)14-28(34,15-27)20-10-7-17(8-11-20)23-24(18-5-3-2-4-6-18)30-16-35-22-12-9-19(26(31)32)13-21(22)25(30)29-23/h2-13,33-34H,14-16H2,1H3,(H,31,32)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126577
PNG
(US8772283, 21)
Show InChI InChI=1S/C28H27N3O3/c1-27(32)15-28(29,16-27)20-10-8-18(9-11-20)24-25(19-6-4-3-5-7-19)31-17-34-23-14-21(33-2)12-13-22(23)26(31)30-24/h3-14,32H,15-17,29H2,1-2H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126620
PNG
(US8772283, 64)
Show InChI InChI=1S/C28H24N2O5/c1-27(33)14-28(34,15-27)20-10-7-17(8-11-20)23-24(18-5-3-2-4-6-18)30-16-35-22-13-19(26(31)32)9-12-21(22)25(30)29-23/h2-13,33-34H,14-16H2,1H3,(H,31,32)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126603
PNG
(US8772283, 46)
Show InChI InChI=1S/C28H24N4O2/c1-27(33)15-28(30,16-27)21-10-8-19(9-11-21)24-25(20-5-3-2-4-6-20)32-17-34-23-12-7-18(14-29)13-22(23)26(32)31-24/h2-13,33H,15-17,30H2,1H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126595
PNG
(US8772283, 39)
Show InChI InChI=1S/C26H24N4O2/c1-25(31)14-26(27,15-25)19-11-9-17(10-12-19)21-22(18-6-3-2-4-7-18)30-16-32-24-20(23(30)29-21)8-5-13-28-24/h2-13,31H,14-16,27H2,1H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126567
PNG
(US8772283, 11)
Show SMILES NC1(CC(O)(C1)C1CC1)c1ccc(cc1)-c1nc2-c3ccccc3OCn2c1-c1ccccc1 |(7.56,3.47,;6.23,4.24,;5.14,5.33,;6.31,6.43,;6.36,7.97,;7.32,5.33,;4.9,7.07,;3.42,6.67,;4.51,8.55,;4.89,3.47,;3.56,4.24,;2.23,3.47,;2.23,1.93,;3.56,1.16,;4.89,1.93,;.93,1.09,;-.5,1.64,;-1.47,.45,;-3.01,.45,;-3.78,1.78,;-5.32,1.78,;-6.09,.45,;-5.32,-.89,;-3.78,-.89,;-3.01,-2.22,;-1.47,-2.22,;-.7,-.89,;.85,-.45,;2.06,-1.41,;1.66,-2.89,;2.75,-3.98,;4.23,-3.58,;4.63,-2.1,;3.54,-1.01,)|
Show InChI InChI=1S/C29H27N3O2/c30-28(16-29(33,17-28)22-14-15-22)21-12-10-19(11-13-21)25-26(20-6-2-1-3-7-20)32-18-34-24-9-5-4-8-23(24)27(32)31-25/h1-13,22,33H,14-18,30H2
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126564
PNG
(US8772283, 8)
Show InChI InChI=1S/C27H24FN3O2/c1-26(32)14-27(29,15-26)19-9-7-17(8-10-19)23-24(18-5-3-2-4-6-18)31-16-33-22-12-11-20(28)13-21(22)25(31)30-23/h2-13,32H,14-16,29H2,1H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126607
PNG
(US8772283, 51)
Show InChI InChI=1S/C27H26N4O3/c1-26(32)14-27(28,15-26)19-10-8-17(9-11-19)22-24(18-6-4-3-5-7-18)31-16-34-20-12-13-21(33-2)29-23(20)25(31)30-22/h3-13,32H,14-16,28H2,1-2H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126593
PNG
(US8772283, 37)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2-c3ccncc3OCn2c1-c1ccccc1
Show InChI InChI=1S/C25H22N4O/c26-25(12-4-13-25)19-9-7-17(8-10-19)22-23(18-5-2-1-3-6-18)29-16-30-21-15-27-14-11-20(21)24(29)28-22/h1-3,5-11,14-15H,4,12-13,16,26H2
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126588
PNG
(US8772283, 32)
Show InChI InChI=1S/C26H24N4O2/c1-25(31)14-26(27,15-25)19-9-7-17(8-10-19)22-23(18-5-3-2-4-6-18)30-16-32-21-11-12-28-13-20(21)24(30)29-22/h2-13,31H,14-16,27H2,1H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126563
PNG
(US8772283, 7)
Show InChI InChI=1S/C26H23FN4O2/c1-25(32)13-26(28,14-25)18-7-5-16(6-8-18)22-23(17-9-11-29-12-10-17)31-15-33-20-4-2-3-19(27)21(20)24(31)30-22/h2-12,32H,13-15,28H2,1H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126602
PNG
(US8772283, 47)
Show InChI InChI=1S/C28H24N4O2/c1-27(33)15-28(30,16-27)21-10-8-19(9-11-21)24-25(20-5-3-2-4-6-20)32-17-34-23-13-18(14-29)7-12-22(23)26(32)31-24/h2-13,33H,15-17,30H2,1H3
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126559
PNG
(US8772283, 3)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2-c3c(F)cccc3OCn2c1-c1ccccc1
Show InChI InChI=1S/C26H22FN3O/c27-20-8-4-9-21-22(20)25-29-23(17-10-12-19(13-11-17)26(28)14-5-15-26)24(30(25)16-31-21)18-6-2-1-3-7-18/h1-4,6-13H,5,14-16,28H2
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
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