Found 41 hits with Last Name = 'osifo' and Initial = 'ik' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Caspase-1
(Homo sapiens (Human)) | BDBM50286304
((R)-3-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methy...)Show SMILES CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C=O Show InChI InChI=1S/C20H27N3O7/c1-12(2)17(23-20(29)30-11-14-7-5-4-6-8-14)19(28)21-13(3)18(27)22-15(10-24)9-16(25)26/h4-8,10,12-13,15,17H,9,11H2,1-3H3,(H,21,28)(H,22,27)(H,23,29)(H,25,26)/t13-,15+,17-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity against IL-1 beta converting enzyme |
Bioorg Med Chem Lett 5: 315-318 (1995)
Article DOI: 10.1016/0960-894X(95)00027-Q
BindingDB Entry DOI: 10.7270/Q2668D5S |
More data for this
Ligand-Target Pair | |
Caspase-1
(Homo sapiens (Human)) | BDBM50176519
((S)-3-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methy...)Show SMILES CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C=O Show InChI InChI=1S/C20H27N3O7/c1-12(2)17(23-20(29)30-11-14-7-5-4-6-8-14)19(28)21-13(3)18(27)22-15(10-24)9-16(25)26/h4-8,10,12-13,15,17H,9,11H2,1-3H3,(H,21,28)(H,22,27)(H,23,29)(H,25,26)/t13-,15-,17-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity against IL-1 beta converting enzyme |
Bioorg Med Chem Lett 5: 315-318 (1995)
Article DOI: 10.1016/0960-894X(95)00027-Q
BindingDB Entry DOI: 10.7270/Q2668D5S |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50286446
(CHEMBL341222 | {(S)-1-[(S)-1-(4-Hydroxy-benzyl)-2-...)Show SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C=O Show InChI InChI=1S/C23H28N2O5/c1-16(2)12-21(25-23(29)30-15-18-6-4-3-5-7-18)22(28)24-19(14-26)13-17-8-10-20(27)11-9-17/h3-11,14,16,19,21,27H,12-13,15H2,1-2H3,(H,24,28)(H,25,29)/t19-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50286452
(CHEMBL340020 | {(S)-1-[(S)-1-(4-Hydroxy-benzyl)-2-...)Show SMILES CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C=O Show InChI InChI=1S/C22H26N2O5/c1-15(2)20(24-22(28)29-14-17-6-4-3-5-7-17)21(27)23-18(13-25)12-16-8-10-19(26)11-9-16/h3-11,13,15,18,20,26H,12,14H2,1-2H3,(H,23,27)(H,24,28)/t18-,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50286449
(CHEMBL338859 | {(S)-1-[(S)-1-(4-Methoxy-benzyl)-2-...)Show SMILES COc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C)C=O)cc1 Show InChI InChI=1S/C23H28N2O5/c1-16(2)21(25-23(28)30-15-18-7-5-4-6-8-18)22(27)24-19(14-26)13-17-9-11-20(29-3)12-10-17/h4-12,14,16,19,21H,13,15H2,1-3H3,(H,24,27)(H,25,28)/t19-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50137397
(CHEMBL341014 | [(S)-1-((S)-1-Benzyl-2-oxo-ethylcar...)Show SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O Show InChI InChI=1S/C23H28N2O4/c1-17(2)13-21(25-23(28)29-16-19-11-7-4-8-12-19)22(27)24-20(15-26)14-18-9-5-3-6-10-18/h3-12,15,17,20-21H,13-14,16H2,1-2H3,(H,24,27)(H,25,28)/t20-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50014577
(CHEMBL286722 | MDL-2170 | Z-Val-Phe-H | [(S)-1-((S...)Show SMILES CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O |r| Show InChI InChI=1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50073850
((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)Show SMILES CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C=O |r| Show InChI InChI=1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50286453
(CHEMBL419423 | {(S)-1-[(S)-1-(4-Hydroxy-benzyl)-2-...)Show SMILES CCC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C=O Show InChI InChI=1S/C23H28N2O5/c1-3-16(2)21(25-23(29)30-15-18-7-5-4-6-8-18)22(28)24-19(14-26)13-17-9-11-20(27)12-10-17/h4-12,14,16,19,21,27H,3,13,15H2,1-2H3,(H,24,28)(H,25,29)/t16?,19-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50286444
(CHEMBL339000 | [(S)-1-((S)-1-Formyl-3-phenyl-propy...)Show SMILES CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)C=O Show InChI InChI=1S/C23H28N2O4/c1-17(2)21(25-23(28)29-16-19-11-7-4-8-12-19)22(27)24-20(15-26)14-13-18-9-5-3-6-10-18/h3-12,15,17,20-21H,13-14,16H2,1-2H3,(H,24,27)(H,25,28)/t20-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50286445
(CHEMBL127613 | [((S)-1-Benzyl-2-oxo-ethylcarbamoyl...)Show SMILES O=C[C@H](Cc1ccccc1)NC(=O)C(NC(=O)OCc1ccccc1)c1ccccc1 Show InChI InChI=1S/C25H24N2O4/c28-17-22(16-19-10-4-1-5-11-19)26-24(29)23(21-14-8-3-9-15-21)27-25(30)31-18-20-12-6-2-7-13-20/h1-15,17,22-23H,16,18H2,(H,26,29)(H,27,30)/t22-,23?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50286454
(CHEMBL129657 | [(S)-1-((S)-1-Formyl-2-naphthalen-1...)Show SMILES CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1cccc2ccccc12)C=O Show InChI InChI=1S/C26H28N2O4/c1-18(2)24(28-26(31)32-17-19-9-4-3-5-10-19)25(30)27-22(16-29)15-21-13-8-12-20-11-6-7-14-23(20)21/h3-14,16,18,22,24H,15,17H2,1-2H3,(H,27,30)(H,28,31)/t22-,24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50286455
(CHEMBL128775 | [(S)-1-((S)-1-Benzyl-2-oxo-ethylcar...)Show SMILES CC(C)(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O Show InChI InChI=1S/C24H30N2O4/c1-24(2,3)15-21(26-23(29)30-17-19-12-8-5-9-13-19)22(28)25-20(16-27)14-18-10-6-4-7-11-18/h4-13,16,20-21H,14-15,17H2,1-3H3,(H,25,28)(H,26,29)/t20-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50286443
(CHEMBL128776 | [(S)-1-((S)-1-Benzyl-2-oxo-ethylcar...)Show SMILES C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O Show InChI InChI=1S/C20H22N2O4/c1-15(21-20(25)26-14-17-10-6-3-7-11-17)19(24)22-18(13-23)12-16-8-4-2-5-9-16/h2-11,13,15,18H,12,14H2,1H3,(H,21,25)(H,22,24)/t15-,18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50286456
(CHEMBL129458 | [(S)-1-((S)-1-Benzyl-2-oxo-ethylcar...)Show SMILES O=C[C@H](Cc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)OCc1ccccc1 Show InChI InChI=1S/C27H28N2O4/c30-19-24(18-22-12-6-2-7-13-22)28-26(31)25(17-16-21-10-4-1-5-11-21)29-27(32)33-20-23-14-8-3-9-15-23/h1-15,19,24-25H,16-18,20H2,(H,28,31)(H,29,32)/t24-,25-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50213272
(CHEBI:6426 | LEUPEPTIN | Leupeptin)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50286450
(CHEMBL128135 | [(S)-1-((S)-1-Benzyl-2-oxo-ethylcar...)Show SMILES O=C[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 Show InChI InChI=1S/C26H26N2O4/c29-18-23(16-20-10-4-1-5-11-20)27-25(30)24(17-21-12-6-2-7-13-21)28-26(31)32-19-22-14-8-3-9-15-22/h1-15,18,23-24H,16-17,19H2,(H,27,30)(H,28,31)/t23-,24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286432
(1-(4-Hydroxy-2-methyl-phenyl)-4-oxo-7-pyridin-4-yl...)Show SMILES Cc1cc(O)ccc1-n1cc(C(N)=O)c(=O)c2ccc(cc12)-c1ccncc1 Show InChI InChI=1S/C22H17N3O3/c1-13-10-16(26)3-5-19(13)25-12-18(22(23)28)21(27)17-4-2-15(11-20(17)25)14-6-8-24-9-7-14/h2-12,26H,1H3,(H2,23,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50286451
(CHEMBL129823 | [1-((S)-1-Benzyl-2-oxo-ethylcarbamo...)Show SMILES CC(C)(C)C(NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O Show InChI InChI=1S/C23H28N2O4/c1-23(2,3)20(25-22(28)29-16-18-12-8-5-9-13-18)21(27)24-19(15-26)14-17-10-6-4-7-11-17/h4-13,15,19-20H,14,16H2,1-3H3,(H,24,27)(H,25,28)/t19-,20?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286434
(1-(2-Chloro-4-hydroxy-phenyl)-4-oxo-7-pyridin-4-yl...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C21H14ClN3O3/c22-17-10-14(26)2-4-18(17)25-11-16(21(23)28)20(27)15-3-1-13(9-19(15)25)12-5-7-24-8-6-12/h1-11,26H,(H2,23,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286434
(1-(2-Chloro-4-hydroxy-phenyl)-4-oxo-7-pyridin-4-yl...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C21H14ClN3O3/c22-17-10-14(26)2-4-18(17)25-11-16(21(23)28)20(27)15-3-1-13(9-19(15)25)12-5-7-24-8-6-12/h1-11,26H,(H2,23,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286442
(1-(2-Chloro-4-hydroxy-phenyl)-4-oxo-7-pyrazol-1-yl...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-n1cccn1 Show InChI InChI=1S/C19H13ClN4O3/c20-15-9-12(25)3-5-16(15)23-10-14(19(21)27)18(26)13-4-2-11(8-17(13)23)24-7-1-6-22-24/h1-10,25H,(H2,21,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50286447
(CHEMBL2370670 | [1-(2-Formyl-pyrrolidine-1-carbony...)Show SMILES CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C=O |r| Show InChI InChI=1S/C18H24N2O4/c1-13(2)16(17(22)20-10-6-9-15(20)11-21)19-18(23)24-12-14-7-4-3-5-8-14/h3-5,7-8,11,13,15-16H,6,9-10,12H2,1-2H3,(H,19,23)/t15-,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain 1/small subunit 1
(Homo sapiens (Human)) | BDBM50286448
(CHEMBL127663 | [(S)-1-((S)-1-Benzyl-2-oxo-ethylcar...)Show SMILES O=C[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)OCc1ccccc1 Show InChI InChI=1S/C30H28N2O4/c33-20-26(18-22-10-3-1-4-11-22)31-29(34)28(32-30(35)36-21-23-12-5-2-6-13-23)19-25-16-9-15-24-14-7-8-17-27(24)25/h1-17,20,26,28H,18-19,21H2,(H,31,34)(H,32,35)/t26-,28-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Calpain 1 by [3H]-acetyl-casein assay |
Bioorg Med Chem Lett 5: 393-398 (1995)
Article DOI: 10.1016/0960-894X(95)00042-R
BindingDB Entry DOI: 10.7270/Q2WQ03R1 |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286430
(1-(4-Hydroxy-phenyl)-4-oxo-7-pyridin-4-yl-1,4-dihy...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C21H15N3O3/c22-21(27)18-12-24(15-2-4-16(25)5-3-15)19-11-14(1-6-17(19)20(18)26)13-7-9-23-10-8-13/h1-12,25H,(H2,22,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286429
(1-(2-Chloro-4-hydroxy-phenyl)-4-oxo-7-pyridazin-3-...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-c1cccnn1 Show InChI InChI=1S/C20H13ClN4O3/c21-15-9-12(26)4-6-17(15)25-10-14(20(22)28)19(27)13-5-3-11(8-18(13)25)16-2-1-7-23-24-16/h1-10,26H,(H2,22,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286440
(1-(2-Chloro-4-hydroxy-phenyl)-7-furan-3-yl-4-oxo-1...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-c1ccoc1 Show InChI InChI=1S/C20H13ClN2O4/c21-16-8-13(24)2-4-17(16)23-9-15(20(22)26)19(25)14-3-1-11(7-18(14)23)12-5-6-27-10-12/h1-10,24H,(H2,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286426
(1-(2-Chloro-4-hydroxy-phenyl)-7-(3-chloro-pyridin-...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-c1ccncc1Cl Show InChI InChI=1S/C21H13Cl2N3O3/c22-16-8-12(27)2-4-18(16)26-10-15(21(24)29)20(28)14-3-1-11(7-19(14)26)13-5-6-25-9-17(13)23/h1-10,27H,(H2,24,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286436
(1-(3-Chloro-4-hydroxy-phenyl)-4-oxo-7-pyridin-4-yl...)Show SMILES NC(=O)c1cn(-c2ccc(O)c(Cl)c2)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C21H14ClN3O3/c22-17-10-14(2-4-19(17)26)25-11-16(21(23)28)20(27)15-3-1-13(9-18(15)25)12-5-7-24-8-6-12/h1-11,26H,(H2,23,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286437
(1-(3-Fluoro-4-hydroxy-phenyl)-4-oxo-7-pyridin-4-yl...)Show SMILES NC(=O)c1cn(-c2ccc(O)c(F)c2)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C21H14FN3O3/c22-17-10-14(2-4-19(17)26)25-11-16(21(23)28)20(27)15-3-1-13(9-18(15)25)12-5-7-24-8-6-12/h1-11,26H,(H2,23,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286435
(1-(3,4-Dihydroxy-phenyl)-4-oxo-7-pyridin-4-yl-1,4-...)Show SMILES NC(=O)c1cn(-c2ccc(O)c(O)c2)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C21H15N3O4/c22-21(28)16-11-24(14-2-4-18(25)19(26)10-14)17-9-13(1-3-15(17)20(16)27)12-5-7-23-8-6-12/h1-11,25-26H,(H2,22,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286433
(1-(2-Fluoro-4-hydroxy-phenyl)-4-oxo-7-pyridin-4-yl...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2F)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C21H14FN3O3/c22-17-10-14(26)2-4-18(17)25-11-16(21(23)28)20(27)15-3-1-13(9-19(15)25)12-5-7-24-8-6-12/h1-11,26H,(H2,23,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286439
(1-(2-Chloro-4-hydroxy-phenyl)-4-oxo-7-pyridin-3-yl...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-c1cccnc1 Show InChI InChI=1S/C21H14ClN3O3/c22-17-9-14(26)4-6-18(17)25-11-16(21(23)28)20(27)15-5-3-12(8-19(15)25)13-2-1-7-24-10-13/h1-11,26H,(H2,23,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286438
(1-(4-Hydroxy-2-trifluoromethyl-phenyl)-4-oxo-7-pyr...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2C(F)(F)F)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C22H14F3N3O3/c23-22(24,25)17-10-14(29)2-4-18(17)28-11-16(21(26)31)20(30)15-3-1-13(9-19(15)28)12-5-7-27-8-6-12/h1-11,29H,(H2,26,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286431
(1-(4-Hydroxy-phenyl)-4-oxo-7-pyridin-4-yl-1,4-dihy...)Show SMILES OC(=O)c1cn(-c2ccc(O)cc2)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C21H14N2O4/c24-16-4-2-15(3-5-16)23-12-18(21(26)27)20(25)17-6-1-14(11-19(17)23)13-7-9-22-10-8-13/h1-12,24H,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Cathepsin L1
(Homo sapiens (Human)) | BDBM50286434
(1-(2-Chloro-4-hydroxy-phenyl)-4-oxo-7-pyridin-4-yl...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C21H14ClN3O3/c22-17-10-14(26)2-4-18(17)25-11-16(21(23)28)20(27)15-3-1-13(9-19(15)25)12-5-7-24-8-6-12/h1-11,26H,(H2,23,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cathepsin L |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Cathepsin (B and K)
(Homo sapiens (Human)) | BDBM50286434
(1-(2-Chloro-4-hydroxy-phenyl)-4-oxo-7-pyridin-4-yl...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C21H14ClN3O3/c22-17-10-14(26)2-4-18(17)25-11-16(21(23)28)20(27)15-3-1-13(9-19(15)25)12-5-7-24-8-6-12/h1-11,26H,(H2,23,28) | PDB
MMDB
Reactome pathway
KEGG
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DrugBank
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Cathepsin B |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286427
(1-(2-Chloro-4-hydroxy-phenyl)-7-(2-fluoro-pyridin-...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-c1ccnc(F)c1 Show InChI InChI=1S/C21H13ClFN3O3/c22-16-9-13(27)2-4-17(16)26-10-15(21(24)29)20(28)14-3-1-11(7-18(14)26)12-5-6-25-19(23)8-12/h1-10,27H,(H2,24,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Calpain1/2
(Homo sapiens (Human)) | BDBM50286428
(1-(2-Chloro-4-hydroxy-phenyl)-4-oxo-7-pyridin-2-yl...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-c1ccccn1 Show InChI InChI=1S/C21H14ClN3O3/c22-16-10-13(26)5-7-18(16)25-11-15(21(23)28)20(27)14-6-4-12(9-19(14)25)17-3-1-2-8-24-17/h1-11,26H,(H2,23,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Cathepsin (B and K)
(Homo sapiens (Human)) | BDBM50286430
(1-(4-Hydroxy-phenyl)-4-oxo-7-pyridin-4-yl-1,4-dihy...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C21H15N3O3/c22-21(27)18-12-24(15-2-4-16(25)5-3-15)19-11-14(1-6-17(19)20(18)26)13-7-9-23-10-8-13/h1-12,25H,(H2,22,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Cathepsin B |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
Cathepsin L1
(Homo sapiens (Human)) | BDBM50286430
(1-(4-Hydroxy-phenyl)-4-oxo-7-pyridin-4-yl-1,4-dihy...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C21H15N3O3/c22-21(27)18-12-24(15-2-4-16(25)5-3-15)19-11-14(1-6-17(19)20(18)26)13-7-9-23-10-8-13/h1-12,25H,(H2,22,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cathepsin L |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q
BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this
Ligand-Target Pair | |
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