new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 41 hits with Last Name = 'parham' and Initial = 'j'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a 30n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged CFMS kinase catalytic domain using biotin-EAIYAPFAKKK-NH2 as substrate after 40 mins by NXT scintillation ...


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Homo sapiens (Human))
BDBM50159550
PNG
(CHEMBL3785336)
Show SMILES COc1c(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc(cc1NS(=O)(=O)CCCN(CCO)CCO)C(C)(C)C
Show InChI InChI=1S/C36H50N4O9S/c1-36(2,3)26-24-30(34(47-4)31(25-26)38-50(45,46)23-7-12-39(13-18-41)14-19-42)37-35(44)33(43)29-10-11-32(28-9-6-5-8-27(28)29)49-22-17-40-15-20-48-21-16-40/h5-6,8-11,24-25,38,41-42H,7,12-23H2,1-4H3,(H,37,44)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 40n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...


Bioorg Med Chem Lett 26: 1901-4 (2016)


BindingDB Entry DOI: 10.7270/Q22R3TJ2
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Homo sapiens (Human))
BDBM50159554
PNG
(CHEMBL3787085)
Show SMILES CCCS(=O)(=O)Nc1cc(cc(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)c1OC)C(C)(C)C
Show InChI InChI=1S/C32H41N3O7S/c1-6-19-43(38,39)34-27-21-22(32(2,3)4)20-26(30(27)40-5)33-31(37)29(36)25-11-12-28(24-10-8-7-9-23(24)25)42-18-15-35-13-16-41-17-14-35/h7-12,20-21,34H,6,13-19H2,1-5H3,(H,33,37)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 50n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...


Bioorg Med Chem Lett 26: 1901-4 (2016)


BindingDB Entry DOI: 10.7270/Q22R3TJ2
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Homo sapiens (Human))
BDBM50159533
PNG
(CHEMBL3786653)
Show SMILES COc1c(NC(=O)C(=O)c2ccc(OCCNC(=O)CN)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C28H34N4O7S/c1-28(2,3)17-14-21(26(38-4)22(15-17)32-40(5,36)37)31-27(35)25(34)20-10-11-23(19-9-7-6-8-18(19)20)39-13-12-30-24(33)16-29/h6-11,14-15,32H,12-13,16,29H2,1-5H3,(H,30,33)(H,31,35)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 50n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...


Bioorg Med Chem Lett 26: 1901-4 (2016)


BindingDB Entry DOI: 10.7270/Q22R3TJ2
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Homo sapiens (Human))
BDBM50159545
PNG
(CHEMBL3785828)
Show SMILES COc1c(NC(=O)C(=O)c2ccc(OCCCCN3CCOCC3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C32H41N3O7S/c1-32(2,3)22-20-26(30(40-4)27(21-22)34-43(5,38)39)33-31(37)29(36)25-12-13-28(24-11-7-6-10-23(24)25)42-17-9-8-14-35-15-18-41-19-16-35/h6-7,10-13,20-21,34H,8-9,14-19H2,1-5H3,(H,33,37)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 50n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...


Bioorg Med Chem Lett 26: 1901-4 (2016)


BindingDB Entry DOI: 10.7270/Q22R3TJ2
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Homo sapiens (Human))
BDBM50159548
PNG
(CHEMBL3785750)
Show SMILES COc1c(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc(cc1NS(=O)(=O)CCCNC(CO)(CO)CO)C(C)(C)C
Show InChI InChI=1S/C36H50N4O10S/c1-35(2,3)25-20-29(33(48-4)30(21-25)39-51(46,47)19-7-12-37-36(22-41,23-42)24-43)38-34(45)32(44)28-10-11-31(27-9-6-5-8-26(27)28)50-18-15-40-13-16-49-17-14-40/h5-6,8-11,20-21,37,39,41-43H,7,12-19,22-24H2,1-4H3,(H,38,45)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 50n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...


Bioorg Med Chem Lett 26: 1901-4 (2016)


BindingDB Entry DOI: 10.7270/Q22R3TJ2
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Homo sapiens (Human))
BDBM50159556
PNG
(CHEMBL3785219)
Show SMILES COc1c(NC(=O)C(=O)c2ccc(OCCN(CCO)CCO)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C30H39N3O8S/c1-30(2,3)20-18-24(28(40-4)25(19-20)32-42(5,38)39)31-29(37)27(36)23-10-11-26(22-9-7-6-8-21(22)23)41-17-14-33(12-15-34)13-16-35/h6-11,18-19,32,34-35H,12-17H2,1-5H3,(H,31,37)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 79n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...


Bioorg Med Chem Lett 26: 1901-4 (2016)


BindingDB Entry DOI: 10.7270/Q22R3TJ2
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Homo sapiens (Human))
BDBM50323654
PNG
(CHEMBL1208829 | N-(5-tert-butyl-2-methoxy-3-(methy...)
Show SMILES COc1c(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C30H37N3O7S/c1-30(2,3)20-18-24(28(38-4)25(19-20)32-41(5,36)37)31-29(35)27(34)23-10-11-26(22-9-7-6-8-21(22)23)40-17-14-33-12-15-39-16-13-33/h6-11,18-19,32H,12-17H2,1-5H3,(H,31,35)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...


Bioorg Med Chem Lett 26: 1901-4 (2016)


BindingDB Entry DOI: 10.7270/Q22R3TJ2
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Homo sapiens (Human))
BDBM50159551
PNG
(CHEMBL3786730)
Show SMILES [Cl-].COc1c(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc(cc1NS(=O)(=O)C[N+]12CCN(CC1)CC2)C(C)(C)C
Show InChI InChI=1S/C36H47N5O7S.ClH/c1-36(2,3)26-23-30(34(46-4)31(24-26)38-49(44,45)25-41-17-11-39(12-18-41)13-19-41)37-35(43)33(42)29-9-10-32(28-8-6-5-7-27(28)29)48-22-16-40-14-20-47-21-15-40;/h5-10,23-24,38H,11-22,25H2,1-4H3;1H
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 158n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...


Bioorg Med Chem Lett 26: 1901-4 (2016)


BindingDB Entry DOI: 10.7270/Q22R3TJ2
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Homo sapiens (Human))
BDBM50159547
PNG
(CHEMBL3786659)
Show SMILES [O-]C(=O)C(F)(F)F.CC[N+](CC)(CC)CCCS(=O)(=O)Nc1cc(cc(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)c1OC)C(C)(C)C
Show InChI InChI=1S/C38H54N4O7S.C2HF3O2/c1-8-42(9-2,10-3)21-13-25-50(45,46)40-33-27-28(38(4,5)6)26-32(36(33)47-7)39-37(44)35(43)31-16-17-34(30-15-12-11-14-29(30)31)49-24-20-41-18-22-48-23-19-41;3-2(4,5)1(6)7/h11-12,14-17,26-27,40H,8-10,13,18-25H2,1-7H3;(H,6,7)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 158n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...


Bioorg Med Chem Lett 26: 1901-4 (2016)


BindingDB Entry DOI: 10.7270/Q22R3TJ2
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Homo sapiens (Human))
BDBM50159553
PNG
(CHEMBL3785530)
Show SMILES COc1c(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc(cc1NS(=O)(=O)CC(O)=O)C(C)(C)C
Show InChI InChI=1S/C31H37N3O9S/c1-31(2,3)20-17-24(29(41-4)25(18-20)33-44(39,40)19-27(35)36)32-30(38)28(37)23-9-10-26(22-8-6-5-7-21(22)23)43-16-13-34-11-14-42-15-12-34/h5-10,17-18,33H,11-16,19H2,1-4H3,(H,32,38)(H,35,36)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 200n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...


Bioorg Med Chem Lett 26: 1901-4 (2016)


BindingDB Entry DOI: 10.7270/Q22R3TJ2
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Homo sapiens (Human))
BDBM50159529
PNG
(CHEMBL3787449)
Show SMILES [O-]C(=O)C(F)(F)F.COc1c(NC(=O)C(=O)c2ccc(OCC[N+](C)(C)C)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C29H37N3O6S.C2HF3O2/c1-29(2,3)19-17-23(27(37-7)24(18-19)31-39(8,35)36)30-28(34)26(33)22-13-14-25(38-16-15-32(4,5)6)21-12-10-9-11-20(21)22;3-2(4,5)1(6)7/h9-14,17-18,31H,15-16H2,1-8H3;(H,6,7)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 501n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...


Bioorg Med Chem Lett 26: 1901-4 (2016)


BindingDB Entry DOI: 10.7270/Q22R3TJ2
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Homo sapiens (Human))
BDBM50159546
PNG
(CHEMBL3786591)
Show SMILES [O-]C(=O)C(F)(F)F.COc1c(NC(=O)C(=O)c2ccc(OCC[N+]3(C)CCOCC3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C31H39N3O7S.C2HF3O2/c1-31(2,3)21-19-25(29(39-5)26(20-21)33-42(6,37)38)32-30(36)28(35)24-11-12-27(23-10-8-7-9-22(23)24)41-18-15-34(4)13-16-40-17-14-34;3-2(4,5)1(6)7/h7-12,19-20,33H,13-18H2,1-6H3;(H,6,7)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...


Bioorg Med Chem Lett 26: 1901-4 (2016)


BindingDB Entry DOI: 10.7270/Q22R3TJ2
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Homo sapiens (Human))
BDBM50159532
PNG
(CHEMBL3786485)
Show SMILES COc1c(NC(=O)C(=O)c2ccc(OCCNC(=O)CC(O)=O)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C29H33N3O9S/c1-29(2,3)17-14-21(27(40-4)22(15-17)32-42(5,38)39)31-28(37)26(36)20-10-11-23(19-9-7-6-8-18(19)20)41-13-12-30-24(33)16-25(34)35/h6-11,14-15,32H,12-13,16H2,1-5H3,(H,30,33)(H,31,37)(H,34,35)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...


Bioorg Med Chem Lett 26: 1901-4 (2016)


BindingDB Entry DOI: 10.7270/Q22R3TJ2
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Homo sapiens (Human))
BDBM50159555
PNG
(CHEMBL3787277)
Show SMILES COc1c(NC(=O)C(=O)c2ccc(OCCN3CCC(CC3)C(O)=O)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C32H39N3O8S/c1-32(2,3)21-18-25(29(42-4)26(19-21)34-44(5,40)41)33-30(37)28(36)24-10-11-27(23-9-7-6-8-22(23)24)43-17-16-35-14-12-20(13-15-35)31(38)39/h6-11,18-20,34H,12-17H2,1-5H3,(H,33,37)(H,38,39)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...


Bioorg Med Chem Lett 26: 1901-4 (2016)


BindingDB Entry DOI: 10.7270/Q22R3TJ2
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>4.80E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged B-RAF after 60 mins by fluorescence polarization assay


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Homo sapiens (Human))
BDBM50159549
PNG
(CHEMBL3786247)
Show SMILES COc1c(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc(cc1NS(=O)(=O)CCCN(CC(O)=O)CC(O)=O)C(C)(C)C
Show InChI InChI=1S/C36H46N4O11S/c1-36(2,3)24-20-28(34(49-4)29(21-24)38-52(47,48)19-7-12-40(22-31(41)42)23-32(43)44)37-35(46)33(45)27-10-11-30(26-9-6-5-8-25(26)27)51-18-15-39-13-16-50-17-14-39/h5-6,8-11,20-21,38H,7,12-19,22-23H2,1-4H3,(H,37,46)(H,41,42)(H,43,44)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 5.01E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...


Bioorg Med Chem Lett 26: 1901-4 (2016)


BindingDB Entry DOI: 10.7270/Q22R3TJ2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged MK2 using K(biotin)KLNRTLSVA as substrate after 2 hrs by scintillation counting


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human PDGFR-1b


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged ERK2 after 60 mins by fluorescence polarization assay


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse LCK


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>1.30E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human FLT3 catalytic domain after by scintillation counting


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>1.30E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human PKCa catalytic domain after by scintillation counting


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>1.30E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human cKIT catalytic domain after by scintillation counting


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>1.30E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human PKCb1 catalytic domain after by scintillation counting


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>1.30E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human JAK2 catalytic domain after by scintillation counting


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>1.60E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SYK


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>1.60E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human ITK


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>1.60E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human JNK3


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>1.60E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged c-SRC autophosphorylation using biotin-(6-amino caproic acid)-AAAQQIYGQ-NH2 as substrate after 40 mins by homogenous t...


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>1.90E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged CDK4 catalytic domain after 30 mins by liquid scintillation counting


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged Tie2 using biotin-(6-amino caproic acid)-LEARLVAYEGWVAGKKK-NH2 after 2 hrs by homogenous time-resolved fluorescence me...


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged VEGFR2 catalytic domain using biotin-aminohexyl-EEEEYFELVAKKKK-NH2 as substrate after 40 mins by homogenous time-resol...


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-4


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>2.40E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ERBB4 using biotin-amino hexanoic acid-RAHEEIYHFFFAKKK-NH2 as substrate after 15 mins by scintillation proximity assay


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>2.40E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ERBB2 using biotin-amino hexanoic acid-RAHEEIYHFFFAKKK-NH2 as substrate after 15 mins by scintillation proximity assay


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>2.40E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged EGFR using biotin-amino hexanoic acid-RAHEEIYHFFFAKKK-NH2 as substrate after 15 mins by scintillation proximity assay


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>2.40E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged PLK1 using biotin-amino hexanoic acid-SFNDTLDFD-NH2 as substrate after 15 mins by scintillation proximity assay


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>2.40E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged PKCz using biotin-(amino hexanoic acid)-FKLKRKGSFKKFA-CONH2 as substrate after 40 mins by scintillation proximity assa...


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Pyruvate dehydrogenase kinase 4 (PDK4)


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>2.80E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged PDHK4 using biotin-YHGHSMSDPGVSYRRR-amide as substrate after 20 mins by scintillation proximity assay


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Homo sapiens (Human))
BDBM50159558
PNG
(CHEMBL3786009)
Show SMILES COc1c(NC(=O)C(=O)c2ccc(OCCN(CC(O)=O)CC(O)=O)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C30H35N3O10S/c1-30(2,3)18-14-22(28(42-4)23(15-18)32-44(5,40)41)31-29(39)27(38)21-10-11-24(20-9-7-6-8-19(20)21)43-13-12-33(16-25(34)35)17-26(36)37/h6-11,14-15,32H,12-13,16-17H2,1-5H3,(H,31,39)(H,34,35)(H,36,37)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a<3.16E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...


Bioorg Med Chem Lett 26: 1901-4 (2016)


BindingDB Entry DOI: 10.7270/Q22R3TJ2
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM32362
PNG
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
Show InChI InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a>3.20E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged GSK-3b using biotin-6-amino caproic acid-AAAKRREILSRRPS(PO3)YR-amide as substrate after 19 mins by NXT scintillation c...


Proc Natl Acad Sci U S A 102: 16078-83 (2005)


Article DOI: 10.1073/pnas.0502000102
BindingDB Entry DOI: 10.7270/Q2PC32TB
More data for this
Ligand-Target Pair